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Clinical outcomes and risk factors for immune recovery and all-cause mortality in Latin Americans living with HIV with virological success: a retrospective cohort study J. Int. AIDS Soc. (IF 6.0) Pub Date : 2024-03-17 Gabriel Castillo-Rozas, Shengxin Tu, Paula Mendes Luz, Fernando Mejia, Juan Sierra-Madero, Vanessa Rouzier, Bryan E. Shepherd, Claudia P. Cortes
Immune reconstitution following antiretroviral therapy (ART) initiation is crucial to prevent AIDS and non-AIDS-related comorbidities. Patients with suppressed viraemia who fail to restore cellular immunity are exposed to an increased risk of morbidity and mortality during long-term follow-up, although the underlying mechanisms remain poorly understood. We aim to describe clinical outcomes and factors
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A conjoint experiment of three placebo rectal products used with receptive anal sex: results from MTN-035 J. Int. AIDS Soc. (IF 6.0) Pub Date : 2024-03-17 José Bauermeister, Willey Lin, Ryan Tingler, Albert Liu, Suwat Chariyalertsak, Craig Hoesley, Pedro Gonzales, Ken Ho, Noel Kayange, Thesla Palanee Phillips, Sherri Johnson, Elizabeth Brown, Jillian Zemanek, Cindy E. Jacobson, Gustavo F. Doncel, Jeanna Piper
End-user perspectives are vital to the design of new biomedical HIV prevention products. Conjoint analysis can support the integration of end-user perspectives by examining their preferences of potential pre-exposure prophylaxis (PrEP) products. The Microbicides Trial Network (MTN) 035 protocol examined three placebo rectal dosage forms (insert, enema and suppository) that could deliver PrEP prior
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Reasons for disengagement from antiretroviral care in the era of “Treat All” in low- or middle-income countries: a systematic review J. Int. AIDS Soc. (IF 6.0) Pub Date : 2024-03-17 Rachael M. Burke, Hannah M. Rickman, Clarice Pinto, Peter Ehrenkranz, Augustine Choko, Nathan Ford
Disengagement from antiretroviral therapy (ART) care is an important reason why people living with HIV do not achieve viral load suppression become unwell.
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Facilitators and barriers to community pharmacy PrEP delivery: a scoping review J. Int. AIDS Soc. (IF 6.0) Pub Date : 2024-03-17 China Harrison, Hannah Family, Joanna Kesten, Sarah Denford, Anne Scott, Sarah Dawson, Jenny Scott, Caroline Sabin, Joanna Copping, Lindsey Harryman, Sarah Cochrane, Jeremy Horwood
Pre-exposure prophylaxis (PrEP) is an effective medication to reduce the risk of acquiring HIV. PrEP is available free of charge in the UK from sexual health clinics. Expanding PrEP delivery to community pharmacies holds promise and aligns with UK government goals to eliminate new cases of HIV by 2030. The aim of this scoping review was to describe the existing evidence about the barriers to and facilitators
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Sexual behaviour and STIs among MSM living with HIV in the PrEP era: the French ANRS PRIMO cohort study J. Int. AIDS Soc. (IF 6.0) Pub Date : 2024-03-10 Virginie Baltes, Paul de Boissieu, Karen Champenois, Louise Luan, Rémonie Seng, Asma Essat, Sophie Novelli, Bruno Spire, Jean-Michel Molina, Cécile Goujard, Laurence Meyer
In a context of declining condom use and high sexually transmitted infection (STI) incidence, the diffusion of “treatment as prevention” (Tasp) and more recently pre-exposure prophylaxis (PrEP) may have changed the sexual behaviour of newly diagnosed men who have sex with men (MSM) with HIV.
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“Emotional stress is more detrimental than the virus itself”: A qualitative study to understand HIV testing and pre‐exposure prophylaxis (PrEP) use among internal migrant men in South Africa J. Int. AIDS Soc. (IF 6.0) Pub Date : 2024-03-11 Maria Francesca Nardell, Caroline Govathson‐Mandimika, Salomé Garnier, Ashley Watts, Dolapo Babalola, Nkosinathi Ngcobo, Lawrence Long, Mark N. Lurie, Jacqui Miot, Sophie Pascoe, Ingrid T. Katz
IntroductionSouth Africa has one of the highest rates of internal migration on the continent, largely comprised of men seeking labour in urban centres. South African men who move within the country (internal migrants) are at higher risk than non‐migrant men of acquiring HIV yet are less likely to test or use pre‐exposure prophylaxis (PrEP). However, little is known about the mechanisms that link internal
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Phase 1 randomized pharmacokinetic and safety study of a 90-day tenofovir vaginal ring in the United States J. Int. AIDS Soc. (IF 6.0) Pub Date : 2024-03-05 Albert Y. Liu, Holly Gundacker, Barbra Richardson, Beatrice A. Chen, Craig Hoesley, Ariane van der Straten, Amanda Brown, May Beamer, Jennifer Robinson, Cindy E. Jacobson, Rachel Scheckter, Katherine Bunge, Jill Schwartz, Andrea Thurman, Jeanna M. Piper, Mark A. Marzinke
Tenofovir-based oral pre-exposure prophylaxis is currently approved for HIV prevention; however, adherence in women has been low. A vaginal gel containing tenofovir (TFV) demonstrated partial protection to HIV but protection was not confirmed in additional studies. Vaginal rings offer user-controlled long-acting HIV prevention that could overcome adherence and protection challenges. TFV may also help
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Bringing together the pieces: the need for holistic care for women with HIV J. Int. AIDS Soc. (IF 6.0) Pub Date : 2024-03-07 Mardge Hillary Cohen, Chantal Benekigeri, Kathryn Anastos
Widespread use of antiretroviral therapy (ART) globally has resulted in dramatic decreases in new HIV acquisitions and markedly lower mortality for people living with HIV (PWH) [1]. Still, in 2022, 630,000 people globally, nearly half of them women, died from AIDS-related illness, and each week 4000 girls and young women aged 15–24 years acquired HIV. Sub-Saharan Africa carries the greatest burden
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Optimizing health resource allocation for improving timely HIV diagnosis in China J. Int. AIDS Soc. (IF 6.0) Pub Date : 2024-03-06 Shihao He, Wei Dong, Christopher K. Fairley, Zengbin Li, Yudong Wei, Hao Lai, Rui Li, Pengyi Lu, Mingwang Shen, Zunyou Wu, Lei Zhang
IntroductionThe Joint United Nations Programme on HIV/AIDS (UNAIDS) updated the 95‐95‐95 targets for the HIV endgame in 2030. To achieve the first target in a timely manner, we investigate the optimized strategy of resource allocation to maximize timely HIV diagnosis in 14 populations in China.MethodsWe developed a mathematical model by integrating epidemiological, demographical and behavioural data
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What does the scale‐up of long‐acting HIV pre‐exposure prophylaxis mean for the global hepatitis B epidemic? J. Int. AIDS Soc. (IF 6.0) Pub Date : 2024-03-06 Amir M. Mohareb, Menan Gérard Kouamé, Marcellin Nouaman, Arthur Y. Kim, Joseph Larmarange, Anne M. Neilan, Karine Lacombe, Kenneth A. Freedberg, Anders Boyd, Patrick Coffie, Emily P. Hyle
IntroductionThe HIV and hepatitis B virus (HBV) epidemics are interconnected with shared routes of transmission and specific antiviral drugs that are effective against both viruses. Nearly, 300 million people around the world live with chronic HBV, many of whom are from priority populations who could benefit from HIV prevention services. Oral pre‐exposure prophylaxis (PrEP) for HIV has implications
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Effect of differentiated direct‐to‐pharmacy PrEP refill visits supported with client HIV self‐testing on clinic visit time and early PrEP continuation J. Int. AIDS Soc. (IF 6.0) Pub Date : 2024-03-06 Kidist Belay Zewdie, Kenneth Ngure, Margaret Mwangi, Dominic Mwangi, Simon Maina, Lydia Etyang, Gakuo Maina, Vallery Ogello, Emmah Owidi, Nelly R. Mugo, Jared M. Baeten, Kenneth K. Mugwanya
IntroductionDelivery of oral pre‐exposure prophylaxis (PrEP) is being scaled up in Africa, but clinic‐level barriers including lengthy clinic visits may threaten client continuation on PrEP.MethodsBetween January 2020 and January 2022, we conducted a quasi‐experimental evaluation of differentiated direct‐to‐pharmacy PrEP refill visits at four public health HIV clinics in Kenya. Two clinics implemented
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Reflecting on a decade of progress: Zero Discrimination Day and the ongoing struggle against transphobia J. Int. AIDS Soc. (IF 6.0) Pub Date : 2024-02-29 Claudia P. Cortes, Omar Sued
On 1 March 2014, the first Zero Discrimination Day was established as a call for eradicating discrimination in all forms and promoting social inclusion and tolerance. Now, 10 years later, it is time to reflect on the important progress in the HIV response but also on the continuous challenges of stigma and discrimination. The availability of self-testing, the efficacy of pre-exposure prophylaxis (PrEP)
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Comparative costs and potential affordability of a multifaceted intervention to improve treatment outcomes among people with HIV who inject drugs in Russia: economic evaluation of the LINC‐II randomized controlled trial J. Int. AIDS Soc. (IF 6.0) Pub Date : 2024-02-26 Sydney Rosen, Elena Blokhina, Ve Truong, Agata Bereznicka, Natalia Gnatienko, Emily Quinn, Dmitry Lioznov, Evgeny Krupitsky, Amy Michals, Karsten Lunze, Jeffrey H. Samet
IntroductionThe LINC‐II randomized controlled trial in St. Petersburg, Russia for HIV‐positive adults who inject drugs found that a multi‐component intervention including initiation of antiretroviral therapy (ART) during admission to an addiction hospital, strengths‐based case management and naltrexone significantly increased 12‐month HIV viral suppression and ART retention. We conducted a comparative
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Integrating methadone into primary care settings in Ukraine: effects on provider stigma and knowledge J. Int. AIDS Soc. (IF 6.0) Pub Date : 2024-02-21 Daniel J. Bromberg, Eteri Machavariani, Lynn M. Madden, Konstantin Dumchev, Katherine LaMonaca, Valerie A. Earnshaw, Iryna Pykalo, Myroslava Filippovych, Marwan S. Haddad, Sergii Dvoriak, Frederick L. Altice
IntroductionStigma has undermined the scale‐up of evidence‐based HIV prevention and treatment. Negative beliefs influence clinicians’ discriminatory behaviour and ultimately have wide‐ranging effects across the HIV prevention and treatment continuum. Stigma among clinicians can be mitigated in several ways, including through interpersonal contact. In this study, we test whether interactions with people
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The development of a conceptual framework on PrEP stigma among adolescent girls and young women in sub‐Saharan Africa J. Int. AIDS Soc. (IF 6.0) Pub Date : 2024-02-21 Miriam Hartmann, Laura Nyblade, Sophie Otticha, Tozoe Marton, Kawango Agot, Sarah T. Roberts
IntroductionStigma is a well‐known barrier to HIV testing and treatment and is an emerging barrier to pre‐exposure prophylaxis (PrEP) use. To guide future research, measurement and interventions, we developed a conceptual framework for PrEP stigma among adolescent girls and young women (AGYW) in sub‐Saharan Africa, a priority population for PrEP.MethodsA literature review, expert consultations and
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My Way: development and preliminary evaluation of a novel delivery system for PrEP and other sexual health needs of young women in Western Kenya J. Int. AIDS Soc. (IF 6.0) Pub Date : 2024-02-21 Jessica E. Haberer, Kevin Oware, Lawrence Juma, Bernard Nyerere, Vincent Momanyi, Josephine Odoyo, Lindsey Garrison, Julita Bhagat, Nicholas Musinguzi, Jared M. Baeten, Aaron Siegler, Elizabeth A. Bukusi
IntroductionYoung women in sub‐Saharan Africa are a priority population for HIV prevention, yet challenges with adherence and persistence to HIV pre‐exposure prophylaxis (PrEP) are common. This study involved the development and pilot testing of My Way—a novel delivery system for PrEP and co‐packaged sexual health services.MethodsMy Way was developed in Kisumu, Kenya through a user‐centred design process
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Knowledge of HIV transmission, prevention strategies and U = U among adult sexual and gender minorities in Brazil J. Int. AIDS Soc. (IF 6.0) Pub Date : 2024-02-21 Kayser Rogerio Oliveira Silva, Rayane Cupolillo Ferreira, Lara E. Coelho, Valdilea G. Veloso, Beatriz Grinsztejn, Thiago S. Torres, Paula M. Luz
IntroductionAlthough strong scientific evidence of the efficacy and effectiveness of treatment‐as‐prevention (TasP) is available, full endorsement of the “Undetectable = Untransmittable” (U = U) and “zero‐risk” messages could be improved. Increasing knowledge about HIV transmission, prevention and treatment is a critical component of care efforts. The study assessed knowledge of HIV transmission and
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Long-term retention on antiretroviral treatment after enrolment in prevention of vertical HIV transmission services: a prospective cohort study in Dar es Salaam, Tanzania J. Int. AIDS Soc. (IF 6.0) Pub Date : 2024-02-08 Roseline Faustine Urrio, Goodluck Willey Lyatuu, David Sando, Michael J. Mahande, Emmanuel Philipo, Helga Naburi, Peter Lyaruu, Amanda Kimonge, Kasasi Mayogu, Brenda Simba, Ayoub Muhamed Kibao, Michael Msangi, Zangin Zeebari, Gunnel Biberfeld, Anna Mia Ekström, Charles Kilewo, Anna E. Kågesten
To prevent vertical HIV transmission and ensure healthy mothers and children, pregnant women with HIV must remain on antiretroviral treatment (ART) for life. However, motivation to remain on ART may decline beyond the standard 2-year breastfeeding/postpartum period. We assessed attrition and retention in ART care among women with HIV up to 6 years since enrolment in vertical transmission prevention
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Temporal dynamics and drivers of durable HIV viral load suppression and persistent high- and low-level viraemia during Universal Test and Treat scale-up in Uganda: a population-based study J. Int. AIDS Soc. (IF 6.0) Pub Date : 2024-02-08 Joseph Gregory Rosen, Robert Ssekubugu, Larry W. Chang, Victor Ssempijja, Ronald M. Galiwango, Joseph Ssekasanvu, Anthony Ndyanabo, Alice Kisakye, Gertrude Nakigozi, Katherine B. Rucinski, Eshan U. Patel, Caitlin E. Kennedy, Fred Nalugoda, Godfrey Kigozi, Oliver Ratmann, Lisa J. Nelson, Lisa A. Mills, Donna Kabatesi, Aaron A. R. Tobian, Thomas C. Quinn, Joseph Kagaayi, Steven J. Reynolds, Mary Kathryn
Population-level data on durable HIV viral load suppression (VLS) following the implementation of Universal Test and Treat (UTT) in Africa are limited. We assessed trends in durable VLS and viraemia among persons living with HIV in 40 Ugandan communities during the UTT scale-up.
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HIV pre-exposure prophylaxis programme preferences among sexually active HIV-negative transgender and gender diverse adults in the United States: a conjoint analysis J. Int. AIDS Soc. (IF 6.0) Pub Date : 2024-02-08 Dovie L. Watson, Louis Listerud, Ryan A. Drab, Willey Y. Lin, Florence Marie Momplaisir, José A. Bauermeister
Current implementation efforts have failed to achieve equitable HIV pre-exposure prophylaxis (PrEP) provision for transgender and gender-diverse (trans) populations. We conducted a choice-based conjoint analysis to measure preferences for key attributes of hypothetical PrEP delivery programmes among a diverse online sample predominantly comprised of transmasculine and nonbinary individuals in the United
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Adaora A. Adimora, in memoriam J. Int. AIDS Soc. (IF 6.0) Pub Date : 2024-01-28 Judith D. Auerbach
The global HIV community has lost a true champion with the passing of Dr. Adaora Alise Adimora on 1 January 2024. Ada was an extraordinary woman, scholar, clinician, mentor, advocate and dear friend who served as the Sarah Graham Kenan Distinguished Professor of Medicine at The University of North Carolina (UNC) at Chapel Hill, United States. She was devoted to elevating attention to women in the HIV
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On the risk of using raw regional data on new HIV infections in France J. Int. AIDS Soc. (IF 6.0) Pub Date : 2024-01-09 Marc-Florent Tassi, Karl Stéfic, Cathie Faussat, Catherine Aumond, Clément Le Roux, Guillaume Gras, Leslie Grammatico-Guillon
Dear Editor, We read with particular interest the article by Wang H et al., analysing the spatio-temporal evolution of pre-exposure prophylaxis (PrEP) use among French men who have sex with men (MSM) over the 2016–2021 period [1], as part of the authorship has been actively promoting and studying PrEP intake for several years in the French Centre-Val de Loire region (CVL): implementation of teleconsultations
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Advanced disease programming brings much needed attention and improvements to inpatient paediatric HIV care in Mozambique J. Int. AIDS Soc. (IF 6.0) Pub Date : 2024-01-09 W. Chris Buck, Andreas Schindele, Elsa Taibo, Patricia Perez, Maria Inês Jorge Tomo de Deus, Mércia Matsinhe, Jessica Cowan, Teresa Beatriz Simione, Aleny Couto
In the early response to the HIV epidemic in Mozambique, paediatric antiretroviral treatment (ART) was principally available in day clinics, located in referral hospitals, with strong linkages between the inpatient wards and outpatient ART clinics. In 2013, the Ministry of Health (MoH) launched an acceleration plan that prioritized decentralization and scale-up of ART services throughout the country
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Assessing HIV risk and the social and behavioural characteristics of gay and bisexual men who have recently migrated to Australia: an analysis of national, behavioural surveillance data 2019–2021 J. Int. AIDS Soc. (IF 6.0) Pub Date : 2024-01-09 Simin Yu, Benjamin R. Bavinton, Curtis Chan, James MacGibbon, Limin Mao, Daniel Vujcich, Timothy R. Broady, Martin Holt
Overseas-born gay and bisexual men (GBM) are overrepresented in HIV diagnoses in Australia. We assessed social and sexual behaviours, and the use of HIV prevention and testing, by region of birth and length of residence in Australia. We sought to identify similarities and differences between recently arrived and non-recently arrived GBM from non-English-speaking countries to improve targeting and engagement
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The promise of a “cure” for HIV: implications for the future of PEPFAR-supported HIV programmes J. Int. AIDS Soc. (IF 6.0) Pub Date : 2024-01-09 Elliot Raizes, John Blandford, Joseph M. McCune, Mark Dybul
As we commemorate the 20th anniversary of the U.S. President's Emergency for AIDS Relief (PEPFAR), there is much to celebrate: over 20 million persons with HIV are receiving life-saving antiretroviral treatment (ART) in over 50 PEPFAR-supported countries [1]. However, external financial support for HIV in low- and middle-income countries (LMICs) remains flat, and overall resources are estimated to
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Response to “On the risk of using raw regional data on new HIV infections in France” by Tassi et al. J. Int. AIDS Soc. (IF 6.0) Pub Date : 2024-01-09 Haoyi Wang, Jean-Michel Molina, Rosemary Dray-Spira, Axel J. Schmidt, Ford Hickson, David van de Vijver, Kai J. Jonas
Our colleagues Tassi et al. submitted a Letter to the Editor regarding our recent paper on the spatio-temporal changes in pre-exposure prophylaxis (PrEP) uptake among men who have sex with men (MSM) in France [1]. We appreciate their interest and constructive feedback, and we seek to address their concerns and provide further clarification. Tassi et al.’s primary concern centred around our utilization
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“I felt special!”: a qualitative study of peer-delivered HIV self-tests, STI self-sampling kits and PrEP for transgender women in Uganda J. Int. AIDS Soc. (IF 6.0) Pub Date : 2023-12-26 Andrew Mujugira, Beyonce Karungi, Jackson Mugisha, Agnes Nakyanzi, Monica Bagaya, Brenda Kamusiime, Alisaati Nalumansi, Grace Kakoola Nalukwago, Vicent Kasiita, Chris Collins Twesigye, Olivia Nampewo, Rogers Nsubuga, Kikulwe Robert Nyanzi, Timothy Muwonge, Monique A. Wyatt, Norma C. Ware, Jessica E. Haberer
Peer delivery is a client-centred approach that could maximize the coverage and impact of HIV services for transgender women (TGW). We conducted qualitative interviews to examine how peer-delivered HIV self-testing (HIVST), sexually transmitted infection self-sampling (STISS) and oral pre-exposure prophylaxis (PrEP) influenced prevention choices among TGW and their intimate partners in Uganda.
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Breaking down relationship barriers to increase PrEP uptake and adherence among adolescent girls and young women in Kenya: safety and preliminary effectiveness results from a pilot cluster-randomized trial J. Int. AIDS Soc. (IF 6.0) Pub Date : 2023-12-20 Sarah T. Roberts, Miriam Hartmann, Alexandra M. Minnis, Sophie Odek Otticha, Erica N. Browne, Elizabeth T. Montgomery, Kawango Agot
Oral pre-exposure prophylaxis (PrEP) has the potential to reduce HIV acquisition among adolescent girls and young women (AGYW) in sub-Saharan Africa, a priority population for epidemic control. However, intimate partner violence (IPV) and low relationship power can create significant challenges to PrEP use. The Tu'Washindi intervention aimed to increase PrEP use by addressing relationship- and violence-related
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PrEP initiation and discontinuation among transgender women in the United States: a longitudinal, mixed methods cohort study J. Int. AIDS Soc. (IF 6.0) Pub Date : 2023-12-20 Erin E. Cooney, Haneefa T. Saleem, Meg Stevenson, Rodrigo A. Aguayo-Romero, Keri N. Althoff, Tonia C. Poteat, S. Wilson Beckham, Dee Adams, Asa E. Radix, Andrew J. Wawrzyniak, Christopher M. Cannon, Jason S. Schneider, J. Sonya Haw, Allan E. Rodriguez, Kenneth H. Mayer, Chris Beyrer, Sari L. Reisner, Andrea L. Wirtz
Transgender women in the United States experience high HIV incidence and suboptimal Pre-exposure prophylaxis (PrEP) engagement. We sought to estimate PrEP initiation and discontinuation rates and characterize PrEP discontinuation experiences among a prospective cohort of transgender women.
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There is no path to ending AIDS by 2030 without improving human rights J. Int. AIDS Soc. (IF 6.0) Pub Date : 2023-12-08 Stefan Baral, Gregorio Millett, Omar Syarif, Nguissali Turpin, Sheree Schwartz
2023 has witnessed worsening human rights contexts around the world with increasing conflict and violence, decreased legal protections and sustained or even increasing criminalization of historically marginalized communities. While the relationship between health and human rights has long been established, the evidence supporting this relationship available in 2023 is unequivocal in demonstrating that
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Effect of a brief alcohol counselling intervention on HIV viral suppression and alcohol use among persons with HIV and unhealthy alcohol use in Uganda and Kenya: a randomized controlled trial J. Int. AIDS Soc. (IF 6.0) Pub Date : 2023-12-06 Sarah B. Puryear, Florence Mwangwa, Fred Opel, Gabriel Chamie, Laura B. Balzer, Jane Kabami, James Ayieko, Asiphas Owaraganise, Elijah Kakande, George Agengo, Elizabeth Bukusi, Stella Kabageni, Daniel Omoding, Melanie Bacon, John Schrom, Sarah Woolf-King, Maya L. Petersen, Diane V. Havlir, Moses Kamya, Judith A. Hahn
Unhealthy alcohol use significantly contributes to viral non-suppression among persons with HIV (PWH). It is unknown whether brief behavioural interventions to reduce alcohol use can improve viral suppression among PWH with unhealthy alcohol use in sub-Saharan Africa (SSA).
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Treatment-naïve people living with HIV aged 50 years or older in Beijing, China, 2010–2020: joinpoint regression model analysis of surveillance data J. Int. AIDS Soc. (IF 6.0) Pub Date : 2023-12-06 Duoduo Wang, Mengge Zhou, Peicheng Wang, Jinjuan Zhang, Yuanqi Mi, Feng Cheng, Jufen Liu
As they age, people living with HIV (PLWH) must face new challenges, such as accelerated ageing and higher rates of comorbidities. This study described the characteristics of HIV acquisition among treatment-naïve PLWH aged ≥50 years and <50 years in Beijing from 2010 to 2020, exploring associated risk factors for comorbidities.
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Population-level effectiveness of pre-exposure prophylaxis for HIV prevention among men who have sex with men in Montréal (Canada): a modelling study of surveillance and survey data J. Int. AIDS Soc. (IF 6.0) Pub Date : 2023-12-06 Carla M. Doyle, Rachael M. Milwid, Joseph Cox, Yiqing Xia, Gilles Lambert, Cécile Tremblay, Joanne Otis, Marie-Claude Boily, Jean-Guy Baril, Réjean Thomas, Alexandre Dumont Blais, Benoit Trottier, Daniel Grace, David M. Moore, Sharmistha Mishra, Mathieu Maheu-Giroux
HIV pre-exposure prophylaxis (PrEP) has been recommended and partly subsidized in Québec, Canada, since 2013. We evaluated the population-level impact of PrEP on HIV transmission among men who have sex with men (MSM) in Montréal, Québec's largest city, over 2013–2021.
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A community-based dynamic choice model for HIV prevention improves PrEP and PEP coverage in rural Uganda and Kenya: a cluster randomized trial J. Int. AIDS Soc. (IF 6.0) Pub Date : 2023-12-06 Elijah R. Kakande, James Ayieko, Helen Sunday, Edith Biira, Marilyn Nyabuti, George Agengo, Jane Kabami, Colette Aoko, Hellen N. Atuhaire, Norton Sang, Asiphas Owaranganise, Janice Litunya, Erick W. Mugoma, Gabriel Chamie, James Peng, John Schrom, Melanie C. Bacon, Moses R. Kamya, Diane V. Havlir, Maya L. Petersen, Laura B. Balzer
Optimizing HIV prevention may require structured approaches for providing client-centred choices as well as community-based entry points and delivery. We evaluated the effect of a dynamic choice model for HIV prevention, delivered by community health workers (CHWs) with clinician support, on the use of biomedical prevention among persons at risk of HIV in rural East Africa.
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Sustaining the HIV/AIDS response: PEPFAR's vision J. Int. AIDS Soc. (IF 6.0) Pub Date : 2023-11-30 John Nkengasong, Michael Ruffner, Maureen Bartee, Ingrid T. Katz, Michael J. A. Reid
Along with partner governments, their civil societies and multilateral organizations, the President's Emergency Plan for AIDS Relief (PEPFAR) has been at the forefront of the global battle against the HIV pandemic for the past two decades. With support from PEPFAR, millions of lives have been saved, including 5.5 million children born HIV-free [1]. Furthermore, many countries in sub-Saharan Africa
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Let us lead: community leadership in the AIDS response is its fundamental pillar for success J. Int. AIDS Soc. (IF 6.0) Pub Date : 2023-11-30 Florence Riako Anam, Sbongile Nkosi, Meirinda Sebayang, Maximina Jokonya, Keren Dunaway, Tariq El Alaoui
The global movement of people living with and affected by HIV has evolved into a first-of-a-kind demonstration of community leadership that connects the grassroots to the global community, powerfully shaping the agenda of the AIDS response. We are known for our powerful presence and voice, actively mobilizing and influencing global policy, financing and action. Over time, we have built infrastructure
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State same-sex marriage policies and pre-exposure prophylaxis implementation among men who have sex with men in the United States J. Int. AIDS Soc. (IF 6.0) Pub Date : 2023-11-23 Julia Raifman, Debbie M. Cheng, Alexandra Skinner, Mark L. Hatzenbuehler, Kenneth H. Mayer, Michael D. Stein
More than 70% of new HIV diagnoses in the United States were among men who have sex with men (MSM) in 2019. Pre-exposure prophylaxis (PrEP) is a transformative innovation for reducing human immunodeficiency virus (HIV) infections. Structural stigma against sexual minorities, including in the form of state-level policies, may affect PrEP implementation. We evaluated whether lower structural stigma reflected
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Getting back on track to ending AIDS in children: it could just be easier than you think J. Int. AIDS Soc. (IF 6.0) Pub Date : 2023-11-20 Shaffiq Essajee, Anurita Bains
The UNAIDS Global AIDS Strategy released in 2021 places ending inequity as the top priority to end AIDS. It recognizes the importance of a rights-based approach to address the needs of populations that have long been neglected in the global AIDS response [1]. Among all people living with HIV, children and adolescents have faced perhaps the greatest inequities in terms of access to treatment and care
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How a menu of adherence support strategies facilitated high adherence to HIV prevention products among adolescent girls and young women in sub-Saharan Africa: a mixed methods analysis J. Int. AIDS Soc. (IF 6.0) Pub Date : 2023-11-07 Sarah T. Roberts, Noah Mancuso, Kristin Williams, Hadijah Kalule Nabunya, Hlengiwe Mposula, Caroline Mugocha, Priscilla Mvinjelwa, Morgan Garcia, Daniel W. Szydlo, Lydia Soto-Torres, Kenneth Ngure, Sybil Hosek
Effective use of pre-exposure prophylaxis (PrEP) has been low among adolescent girls and young women (AGYW) in sub-Saharan Africa. The MTN-034/REACH trial offered AGYW a menu of adherence support strategies and achieved high adherence to both daily oral PrEP and the monthly dapivirine vaginal ring. Understanding how these strategies promoted product use could inform the design of adherence support
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Impact of point-of-care HIV viral load and targeted drug resistance mutation testing on viral suppression among Kenyan pregnant and postpartum women: results from a prospective cohort study (Opt4Mamas) J. Int. AIDS Soc. (IF 6.0) Pub Date : 2023-11-08 Rena C. Patel, Patrick Oyaro, Katherine K. Thomas, Garoma Wakjira Basha, James Wagude, Irene Mukui, Evelyn Brown, Shukri A. Hassan, Eunice Kinywa, Fredrick Oluoch, Francesca Odhiambo, Boaz Oyaro, Leonard Kingwara, Enericah Karauki, Nashon Yongo, Lindah Otieno, Grace C. John-Stewart, Lisa L. Abuogi
Lack of viral suppression (VS) among pregnant and breastfeeding women living with HIV poses challenges for maternal and infant health, and viral load (VL) monitoring via centralized laboratory systems faces many barriers. We aimed to determine the impact of point-of-care (POC) VL and targeted drug resistance mutation (DRM) testing in improving VS among pregnant and postpartum women on antiretroviral
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Transition of a community- and person-centred design for providing healthcare services to gay and bisexual men and other men who have sex with men who engage in chemsex from a facility-based setting to a community-led setting in Taiwan J. Int. AIDS Soc. (IF 6.0) Pub Date : 2023-11-05 Carol Strong, Jing-Hao Hsu, An-Chun Chung, Meng-Tzu Wu, Yi-Hui Wu, Kuo-Wei Lo, Su-Ting Hsu, Nai-Ying Ko
The decline of new HIV acquisitions in Taiwan can be attributed to a combination of rapidly increasing antiretroviral therapy (ART) coverage, the successful implementation of HIV self-testing and the uptake of pre-exposure prophylaxis (PrEP) [1]. With regard to HIV prevention, the key population in Taiwan, gay and bisexual men and other men who have sex with men (GBMSM), has faced new challenges in
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“They test my blood to know how much blood is in my body”: the untapped potential of promoting viral load literacy to support adherence and viral suppression among adolescents living with HIV J. Int. AIDS Soc. (IF 6.0) Pub Date : 2023-10-25 Sarah Bernays, Joni Lariat, Frances Cowan, Beula Senzanje, Nicola Willis, Zivai Mupambireyi Nenguke
Achieving sustained HIV viral suppression is a key strategy to optimize the health and wellbeing of those living with HIV. Sub-optimal adherence to antiretroviral therapy (ART) in adolescents and young people living with HIV (AYPLHIV) in Southern Africa, due to a range of social and contextual factors, including poor mental health, has presented a substantial challenge to meeting targets aimed towards
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COVID-19 vaccine effectiveness by HIV status and history of injection drug use: a test-negative analysis J. Int. AIDS Soc. (IF 6.0) Pub Date : 2023-10-26 Joseph H. Puyat, James Wilton, Adeleke Fowokan, Naveed Zafar Janjua, Jason Wong, Troy Grennan, Catharine Chambers, Abigail Kroch, Cecilia T. Costiniuk, Curtis L. Cooper, Darren Lauscher, Monte Strong, Ann N. Burchell, Aslam Anis, Hasina Samji
People living with HIV (PLWH) and/or who inject drugs may experience lower vaccine effectiveness (VE) against SARS-CoV-2 infection.
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The impact of free antiretroviral therapy for pregnant non-citizens and their infants in Botswana J. Int. AIDS Soc. (IF 6.0) Pub Date : 2023-10-26 Christina Fennell, Daniel Escudero, Rebecca Zash, Modiegi Diseko, Gloria Mayondi, Judith Mabuta, Tumalano Sekoto, Tendani Gaolathe, Mompati Mmalane, Shahin Lockman, Joseph Makhema, Roger Shapiro
In December 2019, the Botswana government expanded free antiretroviral therapy (ART) to include non-citizens. We evaluated the impact of this policy change on antenatal care (ANC), antiretroviral therapy coverage and adverse birth outcomes.
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Population-level analysis of natural control of HIV infection in Zambia and South Africa: HPTN 071 (PopART) J. Int. AIDS Soc. (IF 6.0) Pub Date : 2023-10-27 Wendy Grant-McAuley, Estelle Piwowar-Manning, William Clarke, Autumn Breaud, Kidist Belay Zewdie, Ayana Moore, Helen Mary Ayles, Barry Kosloff, Kwame Shanaube, Peter Bock, Sue-Ann Meehan, Gerald Maarman, Sarah Fidler, Richard Hayes, Deborah Donnell, Susan H. Eshleman
HIV controllers have low viral loads (VL) without antiretroviral treatment (ART). We evaluated viraemic control in a community-randomized trial conducted in Zambia and South Africa that evaluated the impact of a combination prevention intervention on HIV incidence (HPTN 071 [PopART]; 2013–2018).
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Measuring the performance of HIV self-testing at private pharmacies in Kenya: a cross-sectional study J. Int. AIDS Soc. (IF 6.0) Pub Date : 2023-10-17 Katrina F. Ortblad, Benn Kwach, Shengruo Zhang, Magdalene Asewe, Patricia Atieno Ongwen, Rachel C. Malen, Kendall Harkey, Josephine Odoyo, Paul Gathii, Greshon Rota, Monisha Sharma, Daniel Knight Were, Kenneth Ngure, Victor Omollo, Elizabeth Anne Bukusi
HIV self-testing (HIVST) has the potential to support daily oral pre-exposure prophylaxis (PrEP) delivery in private pharmacies, but many national guidelines have not approved HIVST for PrEP dispensing. In Kenya, pharmacy providers are permitted to deliver HIVST, but often do not have the required certification to deliver rapid diagnostic testing (RDT). We estimated the performance of provider-delivered
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Findings from the Tushirikiane mobile health (mHealth) HIV self-testing pragmatic trial with refugee adolescents and youth living in informal settlements in Kampala, Uganda J. Int. AIDS Soc. (IF 6.0) Pub Date : 2023-10-18 Carmen H. Logie, Moses Okumu, Isha Berry, Robert Hakiza, Stefan D. Baral, Daniel Kibuuka Musoke, Aidah Nakitende, Simon Mwima, Peter Kyambadde, Miranda Loutet, Shamilah Batte, Richard Lester, Stella Neema, Katie Newby, Lawrence Mbuagbaw
Urban refugee youth remain underserved by current HIV prevention strategies, including HIV self-testing (HIVST). Examining HIVST feasibility with refugees can inform tailored HIV testing strategies. We examined if HIVST and mobile health (mHealth) delivery approaches could increase HIV testing uptake and HIV status knowledge among refugee youth in Kampala, Uganda.
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Using community conversations to integrate violence screening and referrals into HIV care for young women living with HIV in Lusaka, Zambia J. Int. AIDS Soc. (IF 6.0) Pub Date : 2023-10-11 Christina A. Laurenzi, Chipo Mutambo, Chanda Mwamba, Eugene Mupakile, Chuma Busakhwe, Agnes Ronan, Elona Toska
1 INTRODUCTION Young women living with HIV (YWHIV) commonly experience overlapping vulnerabilities, especially in low-resource, HIV-endemic settings. They are likelier to experience violence, and have poorer antiretroviral adherence, HIV care disengagement and low viral suppression [1]. Despite strong prevention programming, HIV incidence among 15- to 24-year-olds in Zambia remains high, potentially
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World Mental Health Day 2023: We must leave no one behind in the response to HIV and mental health J. Int. AIDS Soc. (IF 6.0) Pub Date : 2023-10-10 Milton L. Wainberg, George Gustaaf Wolvaardt, Lidia Gouveia, Erin Ferenchick
Despite great achievements in the response to HIV over the past four decades, emerging data are alarming. They reveal that progress is faltering with only a 3.5% drop in global acquisitions from 2020 to 2021 - the smallest annual decline since 2016.1 The COVID-19 pandemic and growing humanitarian and climate crises have challenged health systems globally, profoundly impacting the HIV response and threatening
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Field performance and cost-effectiveness of a point-of-care triage test for HIV virological failure in Southern Africa J. Int. AIDS Soc. (IF 6.0) Pub Date : 2023-10-06 Anna Saura-Lázaro, Peter Bock, Erika van den Bogaart, Jessie van Vliet, Laura Granés, Kerry Nel, Vikesh Naidoo, Michelle Scheepers, Yvonne Saunders, Núria Leal, Francesco Ramponi, René Paulussen, Tobias Rinke de Wit, Denise Naniche, Elisa López-Varela
Antiretroviral therapy (ART) monitoring using viral load (VL) testing is challenging in high-burden, limited-resources settings. Chemokine IP-10 (interferon gamma-induced protein 10) strongly correlates with human immunodeficiency virus (HIV) VL. Its determination could serve to predict virological failure (VF) and to triage patients requiring VL testing. We assessed the field performance of a semi-quantitative
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Telehealth effectiveness for pre-exposure prophylaxis delivery in Brazilian public services: the Combine! Study J. Int. AIDS Soc. (IF 6.0) Pub Date : 2023-09-27 Alexandre Grangeiro, Lorruan Alves do Santos, Denize Lotufo Estevam, Rosemeire Munhoz, Érico Arruda, Renata Amaral de Moraes, Lisiane de Quadros Winkler, Lis Aparecida de Souza Neves, Juliane Cardoso Villela Santos, Mariele Kruppa, Eliana Miura Zucchi, Maria Mercedes Escuder, Andréa Fachel Leal, Mitti Ayako Hara Koyama, Maria Fernanda Tourinho Peres, Marcia Thereza Couto, José Eluf Neto
Pre-exposure prophylaxis (PrEP) delivery based on user needs can enhance PrEP access and impact. We examined whether telehealth for daily oral PrEP delivery could change the indicators of care related to prophylactic use in five Brazilian public HIV clinics (testing centres, outpatient clinics and infectious disease hospitals).
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The role of internalised HIV stigma in disclosure of maternal HIV serostatus to children perinatally HIV-exposed but uninfected: a prospective study in the United States. J. Int. AIDS Soc. (IF 6.0) Pub Date : 2023-10-01 Mariam Davtyan,Deborah Kacanek,Jessica Lee,Claire Berman,Ellen G Chadwick,Renee Smith,Liz Salomon,Toinette Frederick,
INTRODUCTION Decisions to disclose HIV serostatus may be complicated by internalised HIV stigma. We evaluated the association of internalised HIV stigma in biological mothers living with HIV with disclosure of their serostatus to their children perinatally HIV-exposed but uninfected (CHEU). METHODS Mothers and their CHEU were enrolled in the United States (U.S.)-based Surveillance Monitoring for Antiretroviral
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Achieving equity for children and adolescents with perinatal HIV exposure: an urgent need for a paradigm shift. J. Int. AIDS Soc. (IF 6.0) Pub Date : 2023-10-01 Jane Namangolwa Mutanga,Agnes Ronan,Kathleen M Powis
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Lower academic performance among children with perinatal HIV exposure in Botswana. J. Int. AIDS Soc. (IF 6.0) Pub Date : 2023-10-01 Kathleen M Powis,Lesedi Lebanna,Sara Schenkel,Gosego Masasa,Samuel W Kgole,Martha Ngwaca,Coulson Kgathi,Paige L Williams,Amy L Slogrove,Roger L Shapiro,Shahin Lockman,Mompati O Mmalane,Joseph M Makhema,Jennifer Jao,Adam R Cassidy
INTRODUCTION Studies have reported a higher risk of suboptimal neurodevelopment among children who are HIV-exposed uninfected (HEU) compared to children HIV-unexposed uninfected (HUU). Actual academic performance among school-aged children by HIV exposure status has not been studied. METHODS Academic performance in Mathematics, Science, English, Setswana and overall among children enrolled in the Botswana-based
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Neurodevelopment among children exposed to HIV and uninfected in sub-Saharan Africa. J. Int. AIDS Soc. (IF 6.0) Pub Date : 2023-10-01 Michelle A Bulterys,Irene Njuguna,Mary Mahy,Laurie A Gulaid,Katheen M Powis,Catherine J Wedderburn,Grace John-Stewart
INTRODUCTION The population of 16 million children exposed to HIV and uninfected (CHEU) under 15 years of age continues to expand rapidly, and the estimated prevalence of CHEU exceeds 20% in several countries in sub-Saharan Africa with high HIV prevalence. Some evidence suggests that CHEU experience suboptimal neurodevelopmental outcomes compared to children born to women without HIV. In this commentary
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Setting the research agenda: involving parents in research on children who are HIV-free. J. Int. AIDS Soc. (IF 6.0) Pub Date : 2023-10-01 Laurette L Bukasa,Angelina Namiba,Matilda Brown,Estelle Ndu'ngu,Mercy Nangwale,Gillian Letting,Patricia Chirwa,Claire Thorne,Shema Tariq
INTRODUCTION There is growing interest in health, developmental and survival outcomes of children who are born HIV-free to women living with HIV (children born HIV-free). To date, the research agenda has been largely determined by researchers, funders and policy makers, with limited involvement of parents, who are key stakeholders. Researchers at UCL Great Ormond Street Institute of Child Health in
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When and how to intervene to improve the health of children born HIV-free. J. Int. AIDS Soc. (IF 6.0) Pub Date : 2023-10-01 Ceri Evans,Andrew J Prendergast
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A trial of nurturing care among children who are HIV-exposed and uninfected in eSwatini. J. Int. AIDS Soc. (IF 6.0) Pub Date : 2023-10-01 Andrea Ruff,Xolisile Dlamini,Bareng As Nonyane,Nicole Simmons,Duncan Kochelani,Fiona Burtt,Fakazi Mlotshwa,Ncamsile Gama,Esca Scheepers,Kathrin Schmitz,Lethokuhle Simelane,Lynn M Van Lith,Maureen M Black
INTRODUCTION Children who are HIV-exposed and uninfected (CHEU) are a growing population at potential risk of poor neurocognitive development. We tested a nurturing care intervention on children's neurocognitive development and maternal depressive symptoms (primary) with mediation through caregiving activities (secondary). METHODS This study was conducted among six intervention and nine comparison
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Strengthening the evidence to improve health outcomes of children with perinatal HIV exposure. J. Int. AIDS Soc. (IF 6.0) Pub Date : 2023-10-01 Sonia Lee,Susannah Allison,Pim Brouwers
INTRODUCTION The number of children exposed to HIV and possibly to antiretroviral therapy (ART) in utero and during breastfeeding and are uninfected (HEU) globally will continue to increase from the estimated 15.9 million in 2021. DISCUSSION There are still significant gaps in our understanding of the impact of HIV and/or ART exposure in children who are HEU, in terms of prevalence/incidence and severity