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Women’s acceptance of two strategies for preventing RSV infant bronchiolitis: maternal immunization or monoclonal antibodies for newborns. Clin. Microbiol. Infect. (IF 14.2) Pub Date : 2024-03-15 Axelle Roblin, Marie Lachâtre, Caroline Charlier, Odile Launay, Vassilis Tsatsaris, Olivia Anselem
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Evaluation of two commercial broth microdilution systems for dalbavancin susceptibility testing of MRSA and other resistant Gram-positive cocci Clin. Microbiol. Infect. (IF 14.2) Pub Date : 2024-03-15 Ilaria Baccani, Alberto Antonelli, Sara Cuffari, Caterina Ferretti, Tommaso Giani, Gian Maria Rossolini
This study aims to evaluate two commercial broth microdilution (BMD) systems, E1-185-100 (Merlin) and FDANDPF (ThermoFisher) for dalbavancin susceptibility testing in comparison with reference broth microdilution assay. Study collection was composed of 200 nonreplicate multidrug-resistant Gram-positive cocci of clinical origin, including 180 methicillin-resistant , 10 vancomycin resistant enterococci
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Availability of drugs and resistance testing for BPaLM regimen for rifampicin-resistant tuberculosis in Europe Clin. Microbiol. Infect. (IF 14.2) Pub Date : 2024-03-13 Gunar Günther, Lorenzo Guglielmetti, Yousra Kherabi, Raquel Duarte, Christoph Lange, Tuberculosis Network European Trials group, Tonia Adamides, Onno Akkerman, Aase Bengaard Andersen, Ágnes Bakos, Agnar Bjarnason, Judith Bruchfeld, Dumitru Chesov, Luigi Ruffo Codecasa, Daniela Cirillo, Manfred Danilovits, Edita Davidavičienė, Raquel Duarte, Maria Luiza De Souza Galvão, Sandrine Garnier, Majlinda Gjocaj
Multidrug-resistant/Rifampicin-resistant tuberculosis (TB) is a major obstacle to successful TB control. The recommendation by the World Health Organization to use bedaquiline, pretomanid, linezolid and moxifloxacin (BPaL(M)) for 6 months, based on results of three trials with high efficacy and low toxicity, has revolutionized treatment options. In this study, representatives of the Tuberculosis Network
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BACTERIAL LOAD IN CEREBROSPINAL FLUID PREDICTS UNFAVOURABLE OUTCOME IN PNEUMOCOCCAL MENINGITIS: A PROSPECTIVE NATIONWIDE COHORT STUDY Clin. Microbiol. Infect. (IF 14.2) Pub Date : 2024-03-11 Nora Chekrouni, Thijs M. van Soest, Ana C. da Cruz Campos, Matthijs C. Brouwer, Diederik van de Beek
The objective of this study was to determine the role of cerebrospinal fluid (CSF) bacterial load in adults with pneumococcal meningitis. We quantified bacterial load in CSF samples from the diagnostic lumbar puncture of adults with community-acquired pneumococcal meningitis. We also measured CSF concentrations of complement 5a (C5a), and determined associations between bacterial load, clinical characteristics
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Alarming Increase in Fluoroquinolone Resistance Among Non-Typhoidal Salmonella Isolates. Clin. Microbiol. Infect. (IF 14.2) Pub Date : 2024-03-09 Yeşim Beşli, Şiran Keske, Bilge Dikenelli, K. Erhan Palaoğlu, Önder Ergönül
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Unexpected increase of severe Mycoplasma pneumoniae pneumonia in adults in Southern Switzerland Clin. Microbiol. Infect. (IF 14.2) Pub Date : 2024-03-09 Christian Garzoni, Enos Bernasconi, Cinzia Zehnder, Simona Frigerio Malossa, Giorgio Merlani, Marco Bongiovanni
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New treatment options for critically important WHO fungal priority pathogens Clin. Microbiol. Infect. (IF 14.2) Pub Date : 2024-03-09 Lisa Kriegl, Matthias Egger, Johannes Boyer, Martin Hoenigl, Robert Krause
Yet often overlooked in public health discourse, fungal infections pose a crucialglobal disease burden associated with annual mortality rates approximately equal to tuberculosis and HIV. In response, the World Health Organization (WHO) published its first global priority list of fungal pathogens in 2022 assigning , , , and to the critical group. This review provides succinct insights on novel antifungals
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Pandemic preparedness beyond COVID-19: what we know, what we do, and what we don’t Clin. Microbiol. Infect. (IF 14.2) Pub Date : 2024-03-08 J, u, a, n, , M, ., , P, e, r, i, c, à, s
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Development and field validation of an RT-LAMP assay for the rapid detection of chikungunya virus in patient and mosquito samples Clin. Microbiol. Infect. (IF 14.2) Pub Date : 2024-03-08 Severino Jefferson Ribeiro da Silva, Jurandy Júnior Ferraz de Magalhães, Quinn Matthews, Ana Luisa Lot Divarzak, Renata Pessôa Germano Mendes, Bárbara Nazly Rodrigues Santos, Diego Guerra de Albuquerque Cabral, Jacilane Bezerra da Silva, Alain Kohl, Keith Pardee, Lindomar Pena
We aimed to develop a reverse transcription loop-mediated isothermal amplification (RT-LAMP) platform for the rapid detection of CHIKV in both patient and mosquito samples from Brazil. We optimized an RT-LAMP assay, then evaluated the sensitivity and specificity using visual detection. In comparison with the RT-qPCR reference method, we validated the utility of this assay as a molecular diagnostic
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Diagnostic Limitations and Challenges in Current Clinical Guidelines and Potential Application of Metagenomic Sequencing to Manage Pulmonary Invasive Fungal Infections in Patients with Haematological Malignancies Clin. Microbiol. Infect. (IF 14.2) Pub Date : 2024-03-08 Sarah Y. Park, Monica I. Ardura, Sean X. Zhang
Pulmonary invasive fungal infections (pIFI) disproportionately affect patients with haematological malignancies (HM). Establishing a rapid and accurate diagnosis of pIFI is challenging. Multiple guidelines recommend diagnostic testing of invasive fungal infections but lack consensus and may contribute to inconsistent diagnostic approaches. To identify key diagnostic challenges and review metagenomic
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Mortality in recipients of allogeneic hematopoietic cell transplantation in the era of cytomegalovirus primary prophylaxis: A single center retrospective Experience Clin. Microbiol. Infect. (IF 14.2) Pub Date : 2024-03-08 Anthony Febres-Aldana, Fareed Khawaja, Oscar Morado-Aramburo, Terri Lynn Shigle, Gabriela Rondon, Joseph Sassine, Amy Spallone, Krithika Srinivasan, Jeremy Ramdial, Amin Alousi, Richard Champlin, George Chen, May Daher, Katayoun Rezvani, Ella J. Ariza-Heredia, Elizabeth J. Shpall, Roy F. Chemaly
Allogeneic hematopoietic cell transplant (allo-HCT) recipients who are cytomegalovirus (CMV)-seronegative have better post-transplant outcomes than CMV-seropositive recipients. Letermovir (LTV) is approved for CMV primary prophylaxis in adults who are CMV-seropositive after allo-HCT, and its use is associated with improved long-term post-transplant outcomes. We analyzed whether LTV has affected the
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A family cluster of Streptococcus pyogenes associated with a fatal early-onset neonatal sepsis Clin. Microbiol. Infect. (IF 14.2) Pub Date : 2024-03-02 Federica Novazzi, Lorenzo Colombini, Simona Perniciaro, Angelo Genoni, Massimo Agosti, Francesco Santoro, Nicasio Mancini
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Characteristics and incidence of infections in patients with multiple myeloma treated by bispecific antibodies: a national retrospective study on the behalf of G2I and Intergroupe Francophone du Myélome Clin. Microbiol. Infect. (IF 14.2) Pub Date : 2024-03-01 Aurélie Jourdes, Elise Cellerin, Cyrille Touzeau, Stéphanie Harel, Blandine Denis, Guillaume Escure, Emmanuel Faure, Simon Jamard, Francois Danion, Cécile Sonntag, Florence Ader, Lionel Karlin, Sarah Soueges, Clarisse Cazelles, Clémentine de La Porte des Vaux, Laurent Frenzel, Fanny Lanternier, Xavier Brousse, Titouan Cazaubiel, Pierre Berger, Aude Collignon, Mathieu Blot, Andrea Pieragostini, Morgane
Bispecific antibodies (BsAbs) are an effective treatment used in relapsed or refractory multiple myeloma. Despite a well-tolerated safety profile, infectious events appear to be frequent in clinical trials. Real-world data on epidemiology, characteristics, risk factors, and outcomes of infections in patients treated with BsAb are still needed. A retrospective, multicentre study in BsAb-treated patients
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Is the T2 magnetic resonance imaging Candida panel a suitable alternative to the SeptiFast for the rapid diagnosis of candidemia in routine clinical practice? Clin. Microbiol. Infect. (IF 14.2) Pub Date : 2024-03-01 Iris Camp, Astrid Füszl, Brigitte Selitsch, Ivonne Kröckel, Katharina Kovac, Markus Wahrmann, Barbara Steinlechner, Johannes Weber, Peter Schellongowski, Christian Zauner, Guerkan Sengölge, Tamara Seitz, Alexander Zoufaly, Barbara Ströbele, Stefan Fuchs, Cornelia Lass-Flörl, Heinz Burgmann, Michael Kundi, Birgit Willinger
The diagnosis of invasive infection remains challenging because of tests with slow turnaround times or mediocre performance. T2magnetic resonance imaging is a new diagnostic tool. We investigated the diagnostic accuracy of the T2Candida panel (T2) in comparison with blood culture (BC) and the SeptiFast (SF) for the detection of five different species among high-risk intensive care unit patients with
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COVID-19 mortality among selective serotonin reuptake inhibitor users: author's reply Clin. Microbiol. Infect. (IF 14.2) Pub Date : 2024-02-29 Marius Ahm Stauning, Dogukan Jesper Gür, Christian Torp-Pedersen, Jens Tingleff
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World Health Organization World Hand Hygiene Day, 5 May 2024. SAVE LIVES: Clean Your Hands campaign: Promoting knowledge and capacity building on infection prevention and control, including hand hygiene, among health and care workers Clin. Microbiol. Infect. (IF 14.2) Pub Date : 2024-02-29 Claire Kilpatrick, Ermira Tartari, Miranda Deeves, Didier Pittet, Benedetta Allegranzi
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Lower (1,3)-β-D-glucan sensitivity and in vitro levels in Candida auris and Candida parapsilosis strains Clin. Microbiol. Infect. (IF 14.2) Pub Date : 2024-02-29 Malgorzata Mikulska, Nadir Ullah, Laura Magnasco, Giulia Codda, Claudia Bartalucci, Franca Miletich, Chiara Sepulcri, Edward Willison, Antonio Vena, Daniele Roberto Giacobbe, Vincenzo di Pilato, Chiara Robba, Lorenzo Ball, Anna Marchese, Matteo Bassetti
The serum (1,3)-β--glucan (BDG) assay gives quicker results and has higher sensitivity than blood cultures; therefore, it is advised for early diagnosis of invasive candidemia and/or discontinuation of empirical therapy. Its sensitivity may depend on different factors. The aim of our study was to analyse the and BDG levels in clinical isolates of three species of responsible for candidemia. , , and
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Cuterebra sp tracheopulmonary myiasis in a traveller returning from Costa Rica Clin. Microbiol. Infect. (IF 14.2) Pub Date : 2024-02-28 Léo-Pol Rio, Guilhem Conquet, Brigitte Langlois, Emmanuelle Varlet-Marie, Laurence Lachaud, Grégoire Pasquier
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Psoriasis with Stemphylium lycopersici infection Clin. Microbiol. Infect. (IF 14.2) Pub Date : 2024-02-27 Ya Min Yang, Dong Ming Li
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Evolutionary dynamics of the novel ST22-PT methicillin-resistant Staphylococcus aureus clone co-harbouring Panton–Valentine leucocidin and duplicated toxic shock syndrome toxin 1 genes Clin. Microbiol. Infect. (IF 14.2) Pub Date : 2024-02-24 Tetsuo Yamaguchi, Kenji Furuno, Kohji Komori, Tomoko Abe, Takahiro Sato, Shinji Ogihara, Kotaro Aoki, Yoshikazu Ishii, Kazuhiro Tateda
Globally, the isolation of community-associated methicillin-resistant (MRSA) harbouring both the Panton–Valentine leucocidin (PVL) and toxic shock syndrome toxin 1 (TSST-1) genes is rare. However, we encountered an outbreak of the ST22-PT clone exhibiting this phenotype in Japan. Notably, the TSST-1 gene was duplicated in most of the strains. This study aimed to elucidate the mechanisms underlying
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All you want to know about Mycobacterium abscessus Clin. Microbiol. Infect. (IF 14.2) Pub Date : 2024-02-23 Emmanuelle Cambau, Giovanni Delogu, Jakko van Ingen, Jean-Louis Herrmann, Kevin Winthrop
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Etiological agent and clinical characteristics of haemorrhagic fever with renal syndrome in the southern Republic of Korea: a genomic surveillance study Clin. Microbiol. Infect. (IF 14.2) Pub Date : 2024-02-23 Sara P. Prayitno, Augustine Natasha, Seonghyeon Lee, Choon-Mee Kim, You Mi Lee, Kyungmin Park, Jongwoo Kim, Seong-Gyu Kim, Jieun Park, Shivani Rajoriya, Gustavo Palacios, Yeonsu Oh, Jin-Won Song, Dong-Min Kim, Won-Keun Kim
High incidences of haemorrhagic fever with renal syndrome (HFRS) have been reported in the southern Republic of Korea (ROK). A distinct southern genotype of (HTNV) was identified in on Jeju Island. However, its association with HFRS cases in southern ROK remains elusive. We investigated the potential of the southern HTNV genotype as an etiological agent of HFRS. Samples from 22 patients with HFRS and
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Identification of gaps in the performance of routine microscopy for the diagnosis of parasitic infections revealed by the Dutch laboratory quality assessment scheme Clin. Microbiol. Infect. (IF 14.2) Pub Date : 2024-02-23 Marrit B. Boonstra, Rob Koelewijn, Eric A.T. Brienen, Kim Tassche-Borggreve, Laetitia M. Kortbeek, Theo G. Mank, Bert Mulder, Foekje Stelma, Lisette van Lieshout, Jaap J. van Hellemond
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Re: First evidence of a mother-to-child transmission of an HIV-1/MO intergroup recombinant form Clin. Microbiol. Infect. (IF 14.2) Pub Date : 2024-02-21 Manon Vautrin, Fabienne Tombette, Vinca Icard, Marie Leoz, Mary-Anne Trabaud, Antoine Ouziel, Luc Panetta, Véronique Lemée, Jean-Christophe Plantier, Alice Moisan
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Orthopox viruses: is the threat growing? Clin. Microbiol. Infect. (IF 14.2) Pub Date : 2024-02-20 Erik Boehm, Kathrin Summermatter, Laurent Kaiser
Smallpox was a major cause of human mortality until its eradication, but the threat of orthopox viruses has not disappeared. Since the eradication of smallpox and the cessation of the related vaccination campaigns, the threat has been growing, as evidenced by the currently ongoing worldwide Mpox outbreak. In addition to threats of an evolving Mpox, we must also be aware of a myriad of other threats
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Lack of detection of Klebsiella aerogenes sub-species in lung infection by the BioFire® FilmArray® pneumonia Panel plus Clin. Microbiol. Infect. (IF 14.2) Pub Date : 2024-02-16 Nathan Nicolau-Guillaumet, Laurent Dortet, Aymeric Jacquemin, Bruno Mourvillier, Anaëlle Muggeo, Thomas Guillard
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Exploring the significance of delayed delivery of antibiotics in the community Clin. Microbiol. Infect. (IF 14.2) Pub Date : 2024-02-16 Adi Turjeman
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'Aspergillus-specific IgG antibodies for diagnosing chronic pulmonary aspergillosis compared to the reference gold standard’ – Author’s reply Clin. Microbiol. Infect. (IF 14.2) Pub Date : 2024-02-14 Helmut J.F. Salzer, Christoph Lange
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Re: ‘COVID-19 mortality among selective serotonin reuptake inhibitor users’ by Stauning et al. Clin. Microbiol. Infect. (IF 14.2) Pub Date : 2024-02-10 Carla P. Rus, J.J. Sandra Kooij
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WHO’s essential medicines and AWaRe: recommendations on first- and second-choice antibiotics for empiric treatment of clinical infections Clin. Microbiol. Infect. (IF 14.2) Pub Date : 2024-02-09 Lorenzo Moja, Veronica Zanichelli, Dominik Mertz, Sumanth Gandra, Bernadette Cappello, Graham S. Cooke, Pem Chuki, Stephan Harbarth, Celine Pulcini, Marc Mendelson, Evelina Tacconelli, Loice Achieng Ombajo, Ronald Chitatanga, Mei Zeng, Monica Imi, Christelle Elias, Per Ashorn, Annamaria Marata, Sarah Paulin, Arno Muller, Awa Aidara-Kane, Teodora Elvira Wi, Wilson Milton Were, Elizabeth Tayler, Albert
The WHO Model List of Essential Medicines (EML) prioritizes medicines that have significant global public health value. The EML can also deliver important messages on appropriate medicine use. Since 2017, in response to the growing challenge of antimicrobial resistance, antibiotics on the EML were reviewed and categorized into three groups: Access, Watch and Reserve, leading to a new categorization
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Major cardiovascular events after COVID-19 in people with HIV Clin. Microbiol. Infect. (IF 14.2) Pub Date : 2024-02-09 Raquel Martín-Iguacel, Sergio Moreno-Fornés, Andreu Bruguera, Jordi Aceitón, Daniel Kwakye Nomah, Ana González-Cordón, Pere Domingo, Adrian Curran, Arkaitz Imaz, David Dalmau Juanola, Joaquim Peraire, Beatriz Borjabad, Laia Arbones Fernandez, Isik Somuncu Johansen, José M. Miró, Jordi Casabona, Josep M. Llibre, PISCIS study group
To assess the effect of COVID-19 on the postacute risk of cardiovascular events (CVEs) among people with HIV (PWH). Population-based matched cohort, including all PWH ≥16 years in the Catalan PISCIS HIV cohort. We estimated the incidence rate of the first CVE after COVID-19, analysed it a composite outcome (2020–2022). We adjusted for baseline differences using inverse probability weighting and used
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Information bias for case definitions and mortality between and within studies over time undermines our understanding of COVID-19 transmission and disease severity Clin. Microbiol. Infect. (IF 14.2) Pub Date : 2024-02-08 Daniel Pan, Hidekazu Nishimura, Julian W. Tang
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Which trial do we need? Percutaneous mechanical aspiration versus medical management alone for treatment of right-sided valvular infective endocarditis Clin. Microbiol. Infect. (IF 14.2) Pub Date : 2024-02-08 Molly Hillenbrand, Ahmad Mourad, Thomas L. Holland, Nicholas A. Turner
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Effectiveness of financial incentives on influenza vaccination among older adults in China: A randomized clinical trial Clin. Microbiol. Infect. (IF 14.2) Pub Date : 2024-02-08 Yang Shen, Jingyu Wang, Jian Wang, Stephen Nicholas, Elizabeth Maitland, Min Lv, Tao Yin, Dawei Zhu
To investigate the short-term and long-term effectiveness of different level of financial incentives on increasing the willingness to vaccinate and vaccine uptake. A randomized controlled trial was conducted to investigate the effectiveness of financial incentives of three groups with monetary incentives (CNY20, CNY40, and CNY60; 1 CNY=0.13EUR) vs a control group - CNY0- on influenza vaccine uptake
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Which trial do we need? Empiric glycopeptides plus clindamycin versus oxazolidinones for suspected toxic shock and necrotizing soft-tissue infections (Toxic EGO) Clin. Microbiol. Infect. (IF 14.2) Pub Date : 2024-02-07 Joshua Osowicki, Fergus Hamilton, Todd C. Lee, Michael Marks, Erin K. McCreary, Emily G. McDonald, Jonathan H. Ryder, Steven Y.C. Tong
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Re: ‘The Effect of Antibiotic Therapy for Clostridioides difficile Infection on Mortality and Other Patient-Relevant Outcomes’ by Stabholz et al. Clin. Microbiol. Infect. (IF 14.2) Pub Date : 2024-02-06 I-Wen Chen, Chia-Li Kao, Kuo-Chuan Hung
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Safeguarding COVID-19 vaccines: establishing the safety of novel vaccine platforms Clin. Microbiol. Infect. (IF 14.2) Pub Date : 2024-02-06 David Shasha
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Vaccination and the risk of post-acute sequelae after COVID-19 in the Omicron-predominant period Clin. Microbiol. Infect. (IF 14.2) Pub Date : 2024-02-06 Kyungmin Huh, Young-Eun Kim, Gi Hwan Bae, Jong Youn Moon, Ji-Man Kang, Jacob Lee, Jang-Whan Bae, Kyong Ran Peck, Jaehun Jung
To assess the association of primary and third doses of vaccination with the risk of post-acute sequelae of COVID-19. This retrospective cohort study utilized a combined database of nationwide healthcare claims data, COVID-19 patient registry, and vaccination records from South Korea. Individuals diagnosed with COVID-19 in the Omicron variant-dominant period of January to March 2022 were tracked for
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TMPRSS2 inhibitors for the treatment of COVID-19 in adults: a systematic review and meta-analysis of randomized clinical trials of nafamostat and camostat mesylate Clin. Microbiol. Infect. (IF 14.2) Pub Date : 2024-02-06 María Patricia Hernández-Mitre, Susan C. Morpeth, Balasubramanian Venkatesh, Thomas E. Hills, Joshua Davis, Robert K. Mahar, Grace McPhee, Mark Jones, James Totterdell, Steven Y.C. Tong, Jason A. Roberts
Synthetic serine protease inhibitors block the cellular enzyme transmembrane protease serine 2 (TMPRSS2) preventing SARS-CoV-2 cell entry. There are two relevant drugs in this class, nafamostat (intravenous formulation) and camostat (oral formulation). To determine whether TMPRSS2 inhibition with nafamostat or camostat is associated with a reduced risk of 30-day all-cause mortality in adults with COVID-19
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Effect of a multimodal prevention strategy on dialysis-associated infection events in outpatients receiving haemodialysis: The DIPS stepped wedge, cluster-randomized trial Clin. Microbiol. Infect. (IF 14.2) Pub Date : 2024-02-03 Beate Weikert, Tobias Siegfried Kramer, Frank Schwab, Chris Graf-Allgeier, Solvy Ingrid Wolke, Petra Gastmeier, Christine Geffers
Patients with haemodialysis catheters are susceptible to dialysis-associated infections, particularly bloodstream infections. There have been few systematic attempts to reduce this burden. Our study aimed to investigate the effect of a multimodal prevention strategy on dialysis-associated infection events (DAIE) among haemodialysis outpatients. A multicentre, stepped wedge cluster-randomized controlled
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How I manage severe bacterial infections in people who inject drugs Clin. Microbiol. Infect. (IF 14.2) Pub Date : 2024-02-03 Andrew J. Stewardson, Joshua S. Davis, Adrian J. Dunlop, Steven Y.C. Tong, Gail V. Matthews
Injecting drug use is a risk factor for severe bacterial infection, but there is limited high-quality evidence to guide clinicians providing care to people who inject drugs. Management can be complicated by mistrust, stigma, and competing patient priorities. To review the management of severe infections in people who inject drugs, using an illustrative clinical scenario of complicated bloodstream infection
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Randomized, placebo-controlled trial of antiviral treatment in patients hospitalized for influenza Clin. Microbiol. Infect. (IF 14.2) Pub Date : 2024-02-03 Krisztina Hosszu-Fellous, Pauline Vetter, Thomas Agoritsas, Laurent Kaiser
Abstract not available
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An open call to join the CMI editorial team: editor in virology Clin. Microbiol. Infect. (IF 14.2) Pub Date : 2024-02-03 Leonard Leibovici
Abstract not available
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Risk of cardiac conduction disorders, and pacemaker implantations among individuals tested for serum Borrelia burgdorferi antibodies, a nationwide, matched, population-based cohort study Clin. Microbiol. Infect. (IF 14.2) Pub Date : 2024-02-03 Malte M. Tetens, Lars Haukali Omland, Ram Dessau, Svend Ellermann-Eriksen, Nanna S. Andersen, Charlotte Sværke Jørgensen, Christian Østergaard, Jacob Bodilsen, Kirstine K. Søgaard, Jette Bangsborg, Alex Christian Nielsen, Jens Kjølseth Møller, Ming Chen, Jesper Hastrup Svendsen, Niels Obel, Anne-Mette Lebech
To investigate the short- and long-term risks of atrioventricular block and other cardiac conduction disorders associated with being tested for () antibodies or seropositivity as measures of confounding by indication and infection, respectively. We performed a nationwide population-based matched cohort study (Denmark, 1993–2021). We included 52 200 Bb-seropositive individuals (stratified as only IgM-seropositive
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Bordetella pertussis isolates in Finland after acellular vaccination: serotype change and biofilm formation Clin. Microbiol. Infect. (IF 14.2) Pub Date : 2024-02-02 Vili Niinikoski, Alex-Mikael Barkoff, Jussi Mertsola, Qiushui He
In Finland, whole cell pertussis vaccine (wP) was introduced in 1952 and was replaced by acellular pertussis vaccine (aP) without fimbrial (FIM) antigen in 2005. We aimed to analyze the changes in serotypes of circulating before and after acellular vaccination, and to explore the relationship between biofilm formation and serotype diversity after introduction of aP vaccine. Serotyping of 1399 isolates
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Dextrose-containing fluids causing false-positive serum galactomannan: a case-control study and interrupted time series analysis Clin. Microbiol. Infect. (IF 14.2) Pub Date : 2024-02-02 Raeseok Lee, In Young Yoo, Eun-Jee Oh, Ae Ran Choi, Dukhee Nho, Sung-Yeon Cho, Jongin Lee, Hye Lim Ahn, Yeon-Joon Park, Dong-Gun Lee
This study aimed to identify the cause of false positive serum Aspergillus antigen galactomannan (GM) results in our center. We conducted a case-control study aiming to elucidate the factors associated with false-positive GM results. Independent risk factors for false-positive GM were evaluated through a multivariable regression analysis. An interrupted time series analysis was used to evaluate the
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Corrigendum to “European society of clinical microbiology and infectious diseases guidelines on diagnosis and treatment of brain abscess in children and adults” [Clin Microbiol and Infect 30(1) (2024 Jan) 66–89 Doi: 10.1016/j.cmi.2023.08.016] Clin. Microbiol. Infect. (IF 14.2) Pub Date : 2024-02-02 Jacob Bodilsen, Quintino Giorgio D'Alessandris, Hilary Humphreys, Mildred A. Iro, Matthias Klein, Katharina Last, Inmaculada López Montesinos, Pasquale Pagliano, Oğuz Reşat Sipahi, Rafael San-Juan, Pierre Tattevin, Majda Thurnher, Rogelio de J. Treviño-Rangel, Matthijs C. Brouwer
Abstract not available
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Clinical relevance, mechanisms, and evolution of polymyxin B heteroresistance carbapenem-resistant Klebsiella pneumoniae: A genomic, retrospective cohort study Clin. Microbiol. Infect. (IF 14.2) Pub Date : 2024-02-01 Qixia Luo, Linna Xu, Yuan Wang, Hao Fu, Tingting Xiao, Wei Yu, Wangxiao Zhou, Kanghui Zhang, Jiaying Shen, Jinru Ji, Chaoqun Ying, Yonghong Xiao
To study the clinical relevance, mechanisms, and evolution of polymyxin B (POLB) heteroresistance in carbapenem-resistant (PHR-CRKP), potentially leading to a significant rise in POLB full resistant (FR) CRKP. 544 CRKP isolates from 154 patients treated with POLB were categorized into PHR and NHR (POLB non-heteroresistance) groups. We conducted statistical analysis to compare clinical implications
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Anti-GM-CSF autoantibodies predict outcome of cryptococcal meningitis in patients not infected with HIV: a cohort study Clin. Microbiol. Infect. (IF 14.2) Pub Date : 2024-01-29 Ying-Kui Jiang, Ling-Hong Zhou, Jia-Hui Cheng, Jun-Hao Zhu, Yu Luo, Li Li, Min Zhu, Rong-Sheng Zhu, Wen-Jia Qiu, Hua-Zhen Zhao, Xuan Wang, Jun-Tian Huang, Oliver A. Cornely, Wen-Hong Zhang, Li-Ping Zhu
Objectives To explore the seroprevalence of anti-granulocyte-macrophage colony-stimulating factor (GM-CSF) autoantibodies in non-HIV cryptococcal meningitis (CM) and assess its predictive value for survival. Methods This is a retrospective study of 12 years of non-HIV CM. We detected serum anti-GM-CSF autoantibodies, evaluated the clinical features and outcomes, together with the exploration of prognostic
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Risk factors for invasive fungal infections after hematopoietic stem cell transplantation: a systematic review and meta-analysis Clin. Microbiol. Infect. (IF 14.2) Pub Date : 2024-01-26 Li Biyun, Han Yahui, Li Yuanfang, Guo Xifeng, Wang Dao
Background Invasive fungal infections (IFIs) are a common infectious complications after hematopoietic stem cell transplantation (HSCT), seriously threatening the survival of patients. Objectives This systematic review aimed to investigate risk factors associated with IFIs following HSCT. Data sources Pubmed, EMBASE, Web of Science, and the Cochrane Library until April 2023. Study eligibility criteria
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Genetic factors associated with acquired phenotypic drug resistance and its compensatory evolution during tuberculosis treatment Clin. Microbiol. Infect. (IF 14.2) Pub Date : 2024-01-28 Guoqin Zhang, Xianhui Sun, Joy Fleming, Fanlei Ran, Jianjun Luo, Hong Chen, Hanfang Ju, Zhirui Wang, Hui Zhao, Chunhua Wang, Fan Zhang, Xiaowei Dai, Xinyu Yang, Chuanyou Li, Yi Liu, Yaguo Wang, Xilin Zhang, Yuan Jiang, Zhilong Wu, Lijun Bi, Hongtai Zhang
Objectives We elucidated the factors, evolution, and compensation of antimicrobial resistance (AMR) in Mycobacterium tuberculosis (MTB) isolates under dual pressure from the intra-host environment and anti-tuberculosis (anti-TB) drugs. Methods This retrospective case–control study included 337 patients with pulmonary tuberculosis from 15 clinics in Tianjin, China, with phenotypic drug susceptibility
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Effectiveness of high-dose vs. standard-dose quadrivalent influenza vaccine against recurrent hospitalisations and mortality in relation to influenza circulation: a post-hoc analysis of the DANFLU-1 randomised clinical trial Clin. Microbiol. Infect. (IF 14.2) Pub Date : 2024-01-28 Niklas Dyrby Johansen, Daniel Modin, Kristoffer Grundtvig Skaarup, Joshua Nealon, Sandrine Samson, Marine Dufournet, Matthew M. Loiacono, Rebecca C. Harris, Carsten Schade Larsen, Anne Marie Reimer Jensen, Nino Emanuel Landler, Brian L. Claggett, Prof Scott D. Solomon, Prof Martin J. Landray, Prof Gunnar H. Gislason, Prof Lars Køber, Prof Jens Ulrik Stæhr Jensen, Pradeesh Sivapalan, Lasse Skafte Vestergaard
Objectives To evaluate the relative effectiveness of high-dose quadrivalent influenza vaccine (QIV-HD) vs. standard-dose quadrivalent influenza vaccine (QIV-SD) against recurrent hospitalisations and its potential variation in relation to influenza circulation. Methods We did a post-hoc analysis of a pragmatic, open-label, randomised trial of QIV-HD vs. QIV-SD conducted during the 2021-2022 influenza
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Re: 'Aspergillus-specific IgG antibodies for diagnosing chronic pulmonary aspergillosis compared to the reference gold standard’ by Salzer et al. Clin. Microbiol. Infect. (IF 14.2) Pub Date : 2024-01-26 Maula Md Tariq, Ray Animesh
Abstract not available
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How do I manage refractory invasive pulmonary aspergillosis Clin. Microbiol. Infect. (IF 14.2) Pub Date : 2024-01-28 Paschalis Vergidis, Parham Sendi, Hassan B. Alkhateeb, M. Hong Nguyen
Invasive aspergillosis is associated with significant morbidity and mortality in patients with haematologic malignancies and haematopoietic cell transplant recipients. The prognosis is worse among patients who have failed primary antifungal treatment. We aim to provide guidance on the diagnosis and management of refractory invasive pulmonary aspergillosis. Using PubMed, we performed a review of original
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Incidence of tuberculosis in Europe 2001-2021 and relationship to gross domestic product (GDP) – the continued need for levelling-up between European nations Clin. Microbiol. Infect. (IF 14.2) Pub Date : 2024-01-23 John E. Moore, Beverley C. Millar
Abstract not available
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Enrichment of Bacteroides fragilis and enterotoxigenic Bacteroides fragilis in CpG island methylator phenotype (CIMP)-high colorectal carcinoma Clin. Microbiol. Infect. (IF 14.2) Pub Date : 2024-01-22 Yasutoshi Takashima, Hidetaka Kawamura, Kazuo Okadome, Satoko Ugai, Koichiro Haruki, Kota Arima, Kosuke Mima, Naohiko Akimoto, Jonathan A. Nowak, Marios Giannakis, Wendy S. Garrett, Cynthia L. Sears, Mingyang Song, Tomotaka Ugai, Shuji Ogino
Objectives Data support that enterotoxigenic Bacteroides fragilis (ETBF) harbouring the Bacteroides fragilis toxin (bft) gene may promote colorectal tumourigenesis through the serrated neoplasia pathway. We hypothesised that ETBF may be enriched in colorectal carcinoma subtypes with high-level CpG island methylator phenotype (CIMP-high), BRAF mutation, and high-level microsatellite instability (MSI-high)
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Severe Fever with Thrombocytopenia Syndrome Complicated by Haemophagocytic Lymphohistiocytosis: A Retrospective Cohort Study Clin. Microbiol. Infect. (IF 14.2) Pub Date : 2024-01-22 Gang Wang, Hong-Han Ge, Lifen Hu, Pei-Jun Guo, Ning Cui, Chuan-Long Zhu, Ling Lin, Wei Liu
Abstract not available
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Tiny trematode bobbing its head Clin. Microbiol. Infect. (IF 14.2) Pub Date : 2024-01-22 Debasish Biswal, Bijay Ranjan Mirdha
Abstract not available
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Solid organ transplantation in SARS-CoV-2 positive recipients: a web-survey among ESGICH members Clin. Microbiol. Infect. (IF 14.2) Pub Date : 2024-01-22 Andrea Lombardi, Paolo Grossi
Abstract not available
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Attributable mortality of infections caused by carbapenem-resistant Enterobacterales: results from a prospective, multinational case-control-control matched cohorts study (EURECA) Clin. Microbiol. Infect. (IF 14.2) Pub Date : 2024-01-22 María Paniagua-García, Jose M. Bravo-Ferrer, Salvador Pérez-Galera, Tomislav Kostyanev, Marlieke E.A. de Kraker, Jan Feifel, Zaira R. Palacios-Baena, Joost Schotsman, Rafael Cantón, George L. Daikos, Biljana Carevic, Gorana Dragovac, Lionel K. Tan, Lul Raka, Adriana Hristea, Pierluigi Viale, Murat Akova, Ángela Cano, Jose María Reguera, Alessandro Bartoloni, Halis Akalin
Objectives To assess the mortality attributable to infections caused by carbapenem-resistant Enterobacterales (CRE) and to investigate the effect of clinical management on differences in observed outcomes in a multinational matched cohort study. Methods A prospective matched-cohorts study (NCT02709408) was performed in 50 European hospitals from March 2016 to November 2018. The main outcome was 30-day