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Clinical course and molecular characterization of human Bocavirus associated with acute lower respiratory tract infections in tertiary care hospital of north India Jpn. J. Infect. Dis. (IF 2.2) Pub Date : 2024-02-29 Subhabrata Sarkar, Mannat Kang, Suresh Kumar Angurana, Shankar Prasad, Ishani Bora, Pankaj Singh, Vikrant Sharma, Meenakshi Rana, Bhartendu Singh, Jayashree Muralidharan, Radha Kanta Ratho
Respiratory samples from 139 hospitalized children were screened for the Human Bocavirus (HBoV) genome. Positive samples were sequenced for partial VP1/VP2 gene followed by molecular and phylogenetic analyses. HBoV positivity was noted in 7.2% (10/139) patients. All HBoV positive children presented with fever followed by cough and respiratory distress (90%; 9/10). Three children developed multisystemic
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Continuous renal replacement therapy improves indicators and short-term survival in people with AIDS manifesting sepsis and acute kidney injury Jpn. J. Infect. Dis. (IF 2.2) Pub Date : 2024-02-29 Jie Zheng, Qiu-jin Yang, Fei Qi, Han-zhang Shen, Le Zhang, Jia-wei Xia
Acquired immune deficiency syndrome (AIDS) is susceptible to numerous complications such as sepsis and acute kidney injury (AKI), leading to adverse outcomes. Continuous renal replacement therapy (CRRT) is becoming increasingly popular in the treatment of sepsis and AKI. This study aimed to verify the effectiveness of CRRT in the treatment of AIDS with sepsis and AKI, to provide new directions for
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STSS by Streptococcus pyogenes emm22 genotype accompanied by CsrS mutation: A case report. Jpn. J. Infect. Dis. (IF 2.2) Pub Date : 2024-02-29 Kaoru Ogawa, Jiro Kamiyama, Tadayoshi Ikebe, Shigemasa Taguchi, Kazuya Kiyota
The patient was a 22-year-old woman with no comorbidities who was transferred to our hospital due to cardiac arrest. Treatment enabled return to spontaneous circulation in the patient before arriving at the hospital. At the hospital, the patient’s vital signs were unstable. Vasopressors and hyperhydration therapy were administered. Computed Tomography (CT) showed no remarkable change that caused the
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First case of necrotizing fasciitis and septicemia caused by Pigmentibacter ruber Jpn. J. Infect. Dis. (IF 2.2) Pub Date : 2024-02-29 Ayumi Niwa, Masahiro Hayashi, Jun Yonetamari, Motohiro Nakamura, Yuta Yokobori, Sodai Yokoyama, Mizuki Ogawa, Rina Ichioka, Ryosuke Kikuchi, Hiroyuki Okura, Shinji Ogura, Nobuyuki Tetsuka, Kaori Tanaka, Hisashi Baba
We herein report the first case of necrotizing fasciitis caused by Pigmentibacter ruber. The isolated strain could not be identified by biochemical characterization and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS). The isolated strain was identified as P. ruber by 16S ribosomal RNA and whole genome sequencing. Although much remains unknown about the pathogenicity
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Dissemination of Urinary Escherichia coli Phylogroup B2 in Provincial and Community Hospitals in Uthai Thani, Central Thailand Jpn. J. Infect. Dis. (IF 2.2) Pub Date : 2024-02-29 Chanihcha Anudit, Pornthip Saraisuwan, Chantana Kimterng, Chanakan Puangmanee, Nicharee Bamphensin, Anusak Kerdsin
Escherichia coli is a Gram-negative bacterium that prominently causes a variety of clinical infections in humans, such as diarrhea, sepsis, and urinary tract infection. This bacterium is a common multidrug-resistant threat in community and hospital settings worldwide. This study examined the antimicrobial susceptibility and genetic relationship based on Clermont phylotyping and ERIC-PCR of 84 E. coli
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Relationship of toll-like receptor 7, 9 and 10 polymorphisms on the severity of COVID-19 Jpn. J. Infect. Dis. (IF 2.2) Pub Date : 2024-01-31 Burcu Bayyurt, Sevgi Baltacı, Nil Özbilüm Şahin, Serdal Arslan, Mehmet Bakır
COVID-19 is an pandemic that is still affecting today and has caused many deaths. Toll-like receptor (TLR) have an important role in the binding of disease agents to host cell, disease susceptibility and severity, host disease resistance, In this study, we investigated frequencies of TLR7 (C.4-151 A/G), TLR9 (T-1486C and G2848A), and TLR10 (720A/C and 992T/A) single nucleotide polymorphisms (SNPs)
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Proton pump inhibitors and risk of bloodstream infection without an identifiable source: a hospital-based case-control study Jpn. J. Infect. Dis. (IF 2.2) Pub Date : 2024-01-31 Shintaro Hayashi, Tomohito Moriyama, Yuichiro Ito, Yuta Harada, Hiroki Dodo, Kana Kumahara, Tatsuji Yogi, Noritsugu Ohashi, Reiji Higashi, Akihiro Mori
The association between proton-pump inhibitor (PPI) use and systemic infections caused by bacterial translocation is unclear. This study aims to investigate whether patients receiving PPI therapy have a higher risk for bloodstream infections (BSI) without an identifiable source of infection, as an alternative indicator of BSI secondary to bacterial translocation. We conducted a hospital-based case–control
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Antimicrobial resistance patterns of common Gram-negative microorganisms isolated from patients with lower respiratory tract infection in a Teaching Hospital in Vietnam Jpn. J. Infect. Dis. (IF 2.2) Pub Date : 2024-01-31 Hoang Huy Le, An Van Nguyen, Luong Huy Vu, Vinh Thi Ha Nguyen, Hoa Quynh Pham, Hung Van Le, Son Thai Nguyen, Hong Thu Le, Hung Viet Dinh, Nam Van Le, Tuan Dinh Le, Minh Nhat Le, Viet Hoang Nguyen, Kien Trung Hoang, Hai Ha Long Le
This cross-sectional study investigated the antimicrobial resistance (AMR) patterns of Gram-negative pathogens isolated from 4,789 hospitalized patients with lower respiratory tract infections (LRTIs). Of the collected specimens, 1,325 (27.7%) specimens tested positive for Gram-negative bacteria. The most prevalent isolates were Acinetobacter baumannii (38.6%), Pseudomonas aeruginosa (33.5%), Klebsiella
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Genetic comparison of human parainfluenza virus type 3 detected in respiratory samples from patients with encephalopathy and airway inflammation in Aichi Prefecture, Japan Jpn. J. Infect. Dis. (IF 2.2) Pub Date : 2024-01-31 Hirokazu Adachi, Hiroko Minagawa, Emi Hirose, Noriko Nakamura, Hitomi Niimi, Noriko Saito, Miyabi Ito, Katsuhiko Sato, Yoshihiro Yasui
Human parainfluenza virus type 3 (HPIV-3, Human respirovirus 3) is the second most frequently detected virus after human respiratory syncytial virus (HRSV) in lower respiratory tract infections in children. HPIV-3, like its close relative respiratory viruses, HRSV and influenza virus, may cause encephalopathy, but the relevance of HPIV-3 as a pathogenic factor in encephalopathy is unknown. We attempted
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The Efficacy and Safety of Nafamostat Mesylate in the Treatment of COVID-19: A Meta-Analysis Jpn. J. Infect. Dis. (IF 2.2) Pub Date : 2024-01-31 Mian Wei, Toni Li, Siyuan Liu, Yushu Wang, Carolyn Tran, Guangyu Ao
Nafamostat mesylate, a synthetic serine protease inhibitor, has demonstrated early antiviral activity against SARS-CoV-2 and anticoagulant properties that may be beneficial in COVID-19. We conducted a meta-analysis evaluating the efficacy and safety of nafamostat mesylate for COVID-19 treatment. PubMed, Embase, Cochrane Library, Scopus, Web of Science, medRxiv and bioRxiv were searched up to July 2023
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β-Lactam Susceptibility of Streptococcus dysgalactiae subsp. equisimilis Jpn. J. Infect. Dis. (IF 2.2) Pub Date : 2024-01-31 Natsumi Nakashima, Wanchun Jin, Jun-ichi Wachino, Shinobu Koyama, Kiyoko Tamai, Yoshichika Arakawa, Kouji Kimura
All clinical isolates of Streptococcus dysgalactiae subsp. equisimilis (SDSE) are considered susceptible to β-lactams, the first-line drugs used for SDSE infections. However, penicillin-non-susceptible SDSE has been reported from Denmark. In this study, we attempted to detect β-lactam-non-susceptible clinical isolates of SDSE in Japan. One hundred and fifty clinical isolates of S. dysgalactiae were
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Inactivation of SARS-CoV-2 in serum using physical methods Jpn. J. Infect. Dis. (IF 2.2) Pub Date : 2024-01-31 Toshihiko Harada, Hirofumi Fujimoto, Shuetsu Fukushi, Koji Ishii, Ken-Ichi Hanaki
Since 2019, many studies on COVID-19, which has caused extensive damage as a pandemic, have been ongoing worldwide. These include serological and biochemical studies using sera from patients and animal models. Testing with these sera must be performed after the inactivation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Heat treatment, UV irradiation, and/or gamma-ray irradiation
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Efficacy of cefiderocol, a novel siderophore cephalosporin, against multi-drug resistant Acinetobacter baumannii clinical isolates in Japan Jpn. J. Infect. Dis. (IF 2.2) Pub Date : 2024-01-31 Yoshitaka Kimura, Nami Hatayama, Yoshinori Sato, Satoshi Nishida, Yusuke Yoshino
Multidrug-resistant Acinetobacter baumannii (MDRAB) is an important pathogen that causes nosocomial infections and is resistant to almost all antibiotics, including carbapenems. Cefiderocol is a novel siderophore cephalosporin that is active against a broad spectrum of Gram-negative bacteria. However, the susceptibility of MDRAB from Japan to cefiderocol has not yet been reported. In this study, we
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Biofilm eradication of Stenotrophomonas maltophilia by Levofloxacin and Trimethoprim-sulfamethoxazole Jpn. J. Infect. Dis. (IF 2.2) Pub Date : 2024-01-31 José Mauricio Del Río-Chacón, Fabián Rojas-Larios, Paola Bocanegra-Ibarias, Daniel Salas-Treviño, Francisco Espinoza-Gómez, Adrián Camacho-Ortiz, Samantha Flores-Treviño
Stenotrophomonas maltophilia is a non-fermenting Gram-negative drug-resistant pathogen causing healthcare-associated infections. Clinical isolates from Mexico were assessed for biofilm production by crystal violet staining. Antimicrobial susceptibility was evaluated using the broth microdilution method in planktonic and biofilm cells. The effect of antibiotics on the biofilm was visualized by fluorescence
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Molecular epidemiology of human metapneumovirus before and after COVID-19 in East Japan in 2017–2022 Jpn. J. Infect. Dis. (IF 2.2) Pub Date : 2023-12-28 Kazuya Shirato, Reiko Suwa, Naganori Nao, Miyuki Kawase, Satoko Sugimoto, Yohei Kume, Mina Chishiki, Takashi Ono, Hisao Okabe, Sakurako Norito, Masatoki Sato, Hiroko Sakuma, Shigeo Suzuki, Mitsuaki Hosoya, Makoto Takeda, Koichi Hashimoto
Human metapneumovirus (hMPV) is genetically classified into two major subgroups, A and B, based on attachment glycoprotein (G) gene sequences, and the A2 subgroup is further separated into three subdivisions A2a, A2b (A2b1), and A2c (A2b2). The appearance of subgroup A2c viruses carrying a 180- or 111-nucleotide duplication in the G gene (A2c180nt-dup or A2c111nt-dup) have been reported in Japan and
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Pancreatic injury is associated with poor prognosis in severe fever with thrombocytopenia syndrome Jpn. J. Infect. Dis. (IF 2.2) Pub Date : 2023-12-28 Mengke Yang, Yang Yang, Aiping Zhang, Mingyue Ni, Manman Liang, Bin Quan, Wenzheng Han, Jianghua Yang
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease. Previous studies have mainly focused on the epidemiological and clinical characteristics of patients with SFTS, while pancreatic injury has received little attention. The purpose of this study is to investigate the effect of pancreatic injury on the prognosis of patients with SFTS. A total of 156 SFTS patients were
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DYSREGULATED LEUKOTRIENE METABOLISM IN COVID-19 PATIENTS Jpn. J. Infect. Dis. (IF 2.2) Pub Date : 2023-12-28 Halef Okan Doğan, Mahir Budak, Kübra Doğan, Gözde Ertürk Zararsız, Serra İlayda Yerlitaş, Serkan Bolat, Onur Şenol, Seyit Ali Büyüktuna, Ergun Pınarbaşı, Rağıp Sarıismailoğlu, Hayrettin Yavuz
The aim of this study was to examine leukotriene metabolism in COVID-19. A total of 180 people were included in the study. Of these, 60 were healthy controls, 60 were patients who needed intensive care unit (ICU), and 60 were patients who did not need intensive care (non-ICU). Serum levels of 5-lipoxygenase (5-LO), 5-LO activating protein (ALOX5AP) and cysteinyl leukotriene (CYSLT) were measured and
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First detection of the Jingmen tick virus in Amblyomma testudinarium ticks from the Kanto district, Japan Jpn. J. Infect. Dis. (IF 2.2) Pub Date : 2023-12-28 Ryo Matsumura, Daisuke Kobayashi, Kyo Itoyama, Haruhiko Isawa
In 2010, the Jingmen tick virus (JMTV) was discovered in ticks in China and has been shown to be distributed in several regions worldwide. Recently, cases of JMTV infection in humans have been reported in China and Kosovo, attracting much attention as an emerging tick-borne disease. In this study, we detected the JMTV genome in Amblyomma testudinarium ticks collected in Kanagawa Prefecture, Japan,
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Cross-neutralization activities of antibodies against 18 lyssavirus glycoproteins Jpn. J. Infect. Dis. (IF 2.2) Pub Date : 2023-12-28 Yusuke Inoue, Yoshihiro Kaku, Michiko Harada, Keita Ishijima, Yudai Kuroda, Kango Tatemoto, Milagros Virhuez-Mendoza, Ayano Nishino, Tsukasa Yamamoto, Satoshi Inoue, Aya Matsuu, Ken Maeda
Some lyssaviruses, including the rabies virus (RABV), induce lethal neurological symptoms in humans. However, commercial vaccines have only been evaluated for their efficacy against RABV and not against other lyssaviruses. To assess cross-reactivity among lyssaviruses, including RABV, sera from rabbits inoculated with human and animal RABV vaccines and polyclonal antibodies from rabbits immunized with
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Difficulty in Serologic Screening for Subclinical Rubella During Pregnancy Jpn. J. Infect. Dis. (IF 2.2) Pub Date : 2023-11-30 Kazuya Hiiragi, Ryosuke Shindo, Satoru Shinoda, Mika Okuda, Keiko Tanaka-Taya, Kentaro Kurasawa, Etsuko Miyagi, Shigeru Aoki
In Japan, rubella antibodies are measured in all pregnant women in order to detect subclinical infection. The study aimed to assess the validity of measuring rubella antibodies to detect subclinical rubella among pregnant women in Japan. This single-center, retrospective study measured rubella hemagglutination inhibition (HI) titers and rubella-specific IgM antibody index values (IgM-values). IgM-values
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Bacterial Infections Versus Viral Infections Preference of ABO Blood Group Phenotype Patient Jpn. J. Infect. Dis. (IF 2.2) Pub Date : 2023-11-30 Jamil Mohammed Abduh Saeed Obaid, Fadhl Ahmed Saeed Al-gashaa
Several studies have established an association between the blood group type and susceptibility to infections. This study aimed to evaluate a correlation between the blood group type and the susceptibility to infection. 558 patients were enrolled in this study who attended at the Althawra Hospital, Ibb city, from March to August 2018. A blood sample was analyzed for complete blood count (CBC) and blood
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High prevalence of carbapenem-resistant Enterobacterales producing OXA-48 among carbapenem-resistant isolates in a regional hospital in central Taiwan Jpn. J. Infect. Dis. (IF 2.2) Pub Date : 2023-11-30 Lii-Tzu Wu, Hong-Thuy Vy Nguyen, Se-Chin Ke, Yi-Pei Lin, Yi-Chun Pang, Ming-Kai Guo, Chih-Ming Chen
In response to rising carbapenem-resistant Enterobacterales (CRE), our study investigated carbapenemase-producing Klebsiella pneumoniae and non-K. pneumoniae epidemiology and genetics. We collected 76 clinical Enterobacterales and four stool surveillance Escherichia coli isolates resistant to ertapenem or imipenem. Using PCR and DNA sequencing, we assessed carbapenemases, extended-spectrum β-lactamases
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Establishment of reference reagents for single-radial-immunodiffusion assay on the 2022/23 seasonal influenza vaccine in Japan and their quality validation Jpn. J. Infect. Dis. (IF 2.2) Pub Date : 2023-11-30 Noriko Shimasaki, Tomoko Kuwahara, Haruna Nishijima, Kazuya Nakamura, Kayoko Sato, Keiko Murano, Shigeyuki Itamura, Yukiko Akahori, Emi Takashita, Noriko Kishida, Tomoko Arita, Mina Nakauchi, Makoto Takeda, Hideki Hasegawa, Akihide Ryo, Yuichi Harada
Potency test of influenza vaccine is currently performed using a single-radial-immunodiffusion (SRID) assay, which requires a reference antigen and anti-hemagglutinin (HA) serum as reference reagents. The reagents must be newly prepared each time the strain used for vaccine production is changed. Establishing reference reagents with consistent quality is, therefore, crucial to accurately and precisely
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A case of Legionella pneumophila serogroup 13 pneumonia based on the detection of serogroup-specific genes in culture-negative sputum Jpn. J. Infect. Dis. (IF 2.2) Pub Date : 2023-11-30 Junji Seto, Jun Takahashi, Mika Sampei, Tatsuya Ikeda, Katsumi Mizuta
Legionella pneumophila serogroup (SG) 1, the main cause of Legionnaires' disease, can be diagnosed with urinary antigen testing kits; however, lower respiratory tract specimen culture is necessary to identify L. pneumophila SG 2–15. We attempted to detect L. pneumophila SG-specific genes in a culture-negative sputum specimen from a patient with pneumonia suspected to have Legionnaires’ disease. Two
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Development of Molecular-based Screening Test for Hepatitis B Virus in Human Plasma Samples Jpn. J. Infect. Dis. (IF 2.2) Pub Date : 2023-11-30 Kevser Hanne Altın, Esra Agel
Despite the HBV vaccine being routinely administered in many countries, the death rate remains significant. Antiviral medications are available for the treatment of HBV infection, but patients encounter various serious complications in cases of chronic HBV infection. The failure of serological tests to detect early viral replication prevents early treatment response. Recently, many studies have demonstrated
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Cleavage activation of respiratory viruses – Half a century of history from Sendai virus to SARS-CoV-2 Jpn. J. Infect. Dis. (IF 2.2) Pub Date : 2023-11-30 Makoto Takeda
For many viruses, cleavage activation of membrane fusion protein by host proteases is required for infection. This knowledge is based on the historical studies on Sendai virus in the 1970s. From the 1970s to the 1990s, the avian influenza virus and Newcastle disease virus were studied, showing a clear link between virulence and host proteases' cleavage activation of viral membrane fusion proteins (hemagglutinin
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Impact of COVID-19 and closed transmission of SARS-CoV-2 during the first wave in Toyama Prefecture, Japan, March 30 to May 18, 2020 Jpn. J. Infect. Dis. (IF 2.2) Pub Date : 2023-10-31 Kosuke Tamura, Noriko Inasaki, Masae Itamochi, Yumiko Saga, Takahisa Shimada, Shunsuke Yazawa, Hitoshi Sasajima, Chikako Kawashiri, Emiko Yamazaki, Tomomi Ichikawa, Hiroyasu Kaya, Yoshihiro Yamamoto, Yoshitomo Morinaga, Seiji Yamashiro, Satoshi Nomura, Shinichi Takeda, Hiroyuki Itoh, Koujiro Hirota, Yukio Horie, Norikazu Hirano, Tsuyoshi Sekizuka, Makoto Kuroda, Hideki Tani, Kazunori Oishi
We studied 226 patients in Toyama Prefecture, notified with COVID-19 during the first wave between March 30 and May 18, 2020. Of the 226 patients, 22 (9.7%) died, of whom most (95%) were aged ≥65 years. A large cluster comprising 59 patients (41 residents and 18 staff members) was identified in a nursing home on April 17. No deaths occurred among the staff members, but 12 of the 41 cases in residents
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General vaccination readiness in Japan: Results from the JASTIS 2023 study Jpn. J. Infect. Dis. (IF 2.2) Pub Date : 2023-10-31 Masaki Machida, Shigeru Inoue, Takahiro Tabuchi
General vaccine hesitancy is a global concern. Clarification of the general vaccination readiness and psychological factors comprising it is an important issue. Previous studies have reported that Japan has one of the lowest vaccine confidence levels worldwide. However, the status of other psychological factors comprising general vaccination readiness in Japan remains unclear. Therefore, we aimed to
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THE LONG-TERM SEROLOGICAL PROFILE OF CORONAVAC VACCINE BASED ON COMORBIDITIES AND HISTORY OF SARS-COV-2 INFECTION IN INDONESIA Jpn. J. Infect. Dis. (IF 2.2) Pub Date : 2023-10-31 Syahrul Chilmi, Tanti Adelia Kesuma, Purwa Adrianta Wibawa, Hani Susianti, Agustin Iskandar, Indah Adhita Wulanda, Caesarius Singgih Wahono, Kusworini Handono
CoronaVac emerged as one of the most widely administered COVID-19 vaccine in Indonesia. Previous research has documented various figures regarding its effectiveness in protecting against COVID-19 in several countries. Therefore, this research aims to assess the long-term immunogenicity profile in individuals with comorbidities or history of SARS-CoV-2 infection. The level of total anti-N Ig and anti-S-RBD
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An experimental study on the addition of bacteria to residual anticancer drugs: evaluation of the effect on bacterial growth Jpn. J. Infect. Dis. (IF 2.2) Pub Date : 2023-10-31 Ken Kikuchi, Rei Miyauchi, Tomoya Yamaguchi, Hayato Sugiura, Taishi Nogami, Yuki Inoue, Haruna Sato, Hideki Sato, Nagatoshi Fujiwara, Shinji Maeda
Using anticancer drugs as an example, we examined the possibility of reusing residual drugs. The use of residual drugs is not widespread because of concerns regarding bacterial contamination. We mixed anticancer drugs with bacteria and investigated their effects on bacterial growth. The anticancer drugs carboplatin, paclitaxel, etoposide, irinotecan, methotrexate, and 5-fluorouracil (5-FU) were mixed
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A Multicenter Study on the Utility of Selective Enrichment Broth for Detection of Group B Streptococcus in Pregnant Women in Japan Jpn. J. Infect. Dis. (IF 2.2) Pub Date : 2023-10-31 Daiki Tanno, Kyoichi Saito, Yasuaki Tomii, Yukari Nakatsuka, Kohei Uechi, Kazutaka Ohashi, Tomoo Hidaka, Yukio Yamadera, Atsuko Hata, Masahiro Toyokawa, Hiroki Shimura
Universal screening for Streptococcus agalactiae, Group B Streptococcus (GBS), in pregnant women is important for preventing severe infectious diseases in neonates. The subculture method using selective enrichment broth has been reported to significantly improve GBS detection in the US; however, this method is not widely practiced in Japan. An insufficiency of large-scale validation is one of the reasons;
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Human keratinocyte entry of noninvasive Streptococcus dysgalactiae subsp. equisimilis from humans and companion animals: relatedness with Lancefield group, source, virulence-associated gene, and antimicrobial resistance phenotype Jpn. J. Infect. Dis. (IF 2.2) Pub Date : 2023-09-29 Haruno Yoshida, Yoshiko Takayama, Mieko Goto, Takahiro Maeda, Yuzo Tsuyuki, Takashi Takahashi
We evaluated cell invasion ability (CIA) of noninvasive Streptococcus dysgalactiae subsp. equisimilis using human keratinocyte and determined associations of CIA populations with their host and microbiological traits. Forty-two isolates from humans and companion animals were selected with host information. We measured human keratinocyte CIA, in addition to virulence-associated gene (VAG, spegg–ska
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Difference in the Dynamics of Antibody Titer between COVID-19 Vaccination and SARS-CoV-2 Infection in Healthcare Workers –A Case Study Based on Long-Term and Dense Measurement of Antibody Titer Jpn. J. Infect. Dis. (IF 2.2) Pub Date : 2023-09-29 Hirotaka Tanaka, Hiroyuki Sawatari, Shin-ichi Ando
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is prevalent worldwide, and effective and safe vaccines against the virus have been developed. Although trends in antibody titers after vaccination and/or SARS-CoV-2 infection have been reported, the length and frequency of the measurements are limited. This case report describes the long-term and detailed trends in the anti-SARS-CoV-2 S
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Pulmonary Tuberculosis Incidence among Interferon-gamma Release Assays Positive Latent Tuberculosis Infection with Fibrotic Lesions in an Urban Vulnerable Population of Osaka City, Japan, 2015-2021 Jpn. J. Infect. Dis. (IF 2.2) Pub Date : 2023-09-29 Jun Komukai, Kenji Matsumoto, Wakaba Fukushima, Shinzoh Kudoh
Latent tuberculosis infection (LTBI) with fibrotic lesions (FL) can progress to active tuberculosis (TB). Previous studies did not use interferon-gamma release assays (IGRAs) but used tuberculin skin tests for LTBI diagnosis, whose specificity was lower. This study evaluated the incidence of active TB among LTBI with FL who were diagnosed with IGRAs in Nishinari District, Osaka City. In total, 54 men
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Standardization of the Japanese National Standard, equine botulinum antitoxin Type A, and factors affecting standardization Jpn. J. Infect. Dis. (IF 2.2) Pub Date : 2023-08-31 Masahiro Yutani, Mitsutoshi Senoh, Hiroko Yano, Tsuyoshi Kenri, Masaaki Iwaki
Equine botulinum antitoxin is one of the most popular countermeasures for human botulism. The unitage of the antitoxin product is defined according to national minimum requirement or pharmacopoeia in each country by referring to national standard antitoxins for four types (A, B, E, and F). With the expected depletion of the national standard antitoxins, replacement national standard antitoxins are
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Extensively-drug resistant (XDR) Klebsiella pneumoniae associated with complicated urinary tract infection in Northern India Jpn. J. Infect. Dis. (IF 2.2) Pub Date : 2023-08-31 Parinitha Kaza, Xavier Basil Britto, Jaspreet Mahindroo, Nisha Singh, Stephen Baker, To Nguyen Thi Nguyen, Ravimohan Suryanarayana Mavuduru, Balvinder Mohan, Neelam Taneja
Klebsiella pneumoniae (Kp) associated with hospital acquired infections are extensively-drug resistant (XDR), making treatment problematic. Understanding the genetic epidemiology of XDR -Kp can determine their potential to be hypervirulent (hv) through the presence of siderophores. We characterized genomes of 18 colistin-resistant XDR-Kp isolated from 14 patients with complicated urinary tract infection
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Role of MyD88-adaptor-like (MAL) gene polymorphism rs8177374 and the levels of cytokines (IFN-γ, TNF-α, IL-10, TGF-β) in various malaria manifestations upon P. falciparum and P. vivax infections Jpn. J. Infect. Dis. (IF 2.2) Pub Date : 2023-08-31 Asima Rani, Syed Kashif Nawaz, Muhammad Arshad, Najma Arshad
This study investigated the role of genetic variant rs8177374 in MAL/TIRAP gene in mediating the cytokine levels of IFN-γ, TNF-α, IL-10 and TGF-β in malaria patients due to P. falciparum or P. vivax infection. The study included human blood samples of malaria patients (n=228) and healthy controls (n=226). P. falciparum and P. vivax groups were established based on the causative species of Plasmodium
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Transmission cycle of Shimokoshi type Orientia tsutsugamushi in Shimane Prefecture, Japan. Jpn. J. Infect. Dis. (IF 2.2) Pub Date : 2023-08-31 Naoki Fujisawa, Hiromi Fujita, Nobuko Fujita, Tomotake Sakai, Jun Kawase, Shuji Ando, Kenji Tabara
To demonstrate the transmission cycle of Shimokoshi type Orientia tsutsugamushi in Shimane prefecture, field rodents were captured from areas where four human infections caused by the pathogen were reported. The rodents were investigated for the transmission cycle of the pathogen based on the pathogen’s genome, antibodies against the pathogen, and vector of the pathogen (Leptotrombidium palpale). In
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First detection of chimeric β-lactamase CTX-M-64-producing Salmonella Typhimurium from a domestic source in Japan Jpn. J. Infect. Dis. (IF 2.2) Pub Date : 2023-08-31 Tomu Kamijo, Kazuki Horiuchi, Tatsuya Negishi, Tatsuya Natori, Taku Yamane, Ayaka Hachiro, Takeshi Uehara, Wataru Hayashi, Noriyuki Nagano
Salmonella enterica subsp. enterica serovar Typhimurium has recently emerged worldwide as a producer of extended-spectrum β-lactamase (ESBLs). However, such resistant clinical isolates are still rare in Japan. The common types of ESBLs found are the CTX-M type β-lactamases, including novel ones such as CTX-M-64. CTX-M-64 has a chimeric structure that is a combination of the CTX-M-1 and CTX-M-9 groups
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Importance of toxin genes and polymerase chain reaction-based open reading frame type (POT) analysis for severe Staphylococcus aureus infection in children Jpn. J. Infect. Dis. (IF 2.2) Pub Date : 2023-08-31 Noriko Takeuchi, Naruhiko Ishiwada
In the present study, 26 Staphylococcus aureus strains, including 16 methicillin-resistant S. aureus (MRSA) and 10 methicillin-susceptible S. aureus (MSSA), which were collected from eight medical institutions in Chiba Prefecture that requested toxin gene analysis from 2015 to 2021, were analyzed. A total of 14 Panton-Valentine leukocidin (PVL) positive strains were identified, including one of MSSA
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Is financial social support for tuberculosis patients leading to better treatment outcomes, Türkiye, 2018–2019? Jpn. J. Infect. Dis. (IF 2.2) Pub Date : 2023-08-31 Selda Sahan, Seher Topluoglu, Fehminaz Temel, Mehmet Enes Gokler, Sedat Kaygusuz
The aim of this study was to determine influencing factors including regular financial social support program on tuberculosis (TB) treatment outcomes and success rates. TB patients registered 2018-2019 were included for this retrospective cohort study. We classified into two groups as those who received financial support for at least one month and those who did not. A total of 22867 patients were included
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Mycobacterium tuberculosis Rv2653 protein promotes inflammation response by enhancing glycolysis Jpn. J. Infect. Dis. (IF 2.2) Pub Date : 2023-07-31 Yaman Du, Rui Zheng, Hongli Yin, Li Ma, Jingfang Li, Yun Chen, Xi Zhang, Pengzuo Tao, Lili Gao, Li Yang, Liang He
Mycobacterium tuberculosis (M.tb) infection caused communicable disease tuberculosis (TB) is a major cause of ill health and one of the leading causes of death worldwide. Protein encoded by region of deletion (RD) of M.tb mediated the pathogenic properties of M.tb through inducing inflammation response or disrupting host cell metabolism. We cloned and purified Rv2653 protein from RD13 to explore its
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Neutrophil-to-Lymphocyte Ratio and Systemic Immune-Inflammation Index: Biomarkers in Infants with Bronchiolitis: A Cross-Sectional Study Jpn. J. Infect. Dis. (IF 2.2) Pub Date : 2023-07-31 Özlem Erdede, Erdal Sarı, Nihan Uygur Külcü, Rabia Gönül Sezer Yamanel
The use of the novel inflammatory indicator—systemic immune-inflammatory index (SII)—in pediatric patients with bronchiolitis remains unreported. Therefore, this study investigated the relationship between the SII and neutrophil-to-lymphocyte ratio (NLR) in patients with respiratory syncytial virus (RSV) and non-RSV bronchiolitis and clinical severity prediction. This study analyzed the data of 155
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Knowledge about hepatitis E and influencing factors among the residents in Qingdao: A cross-sectional study Jpn. J. Infect. Dis. (IF 2.2) Pub Date : 2023-06-30 Wenliang Fei, Wencheng Wang, Xiaofan Li, Sicheng Hao, Feng Yang
Hepatitis E infection is an important problem in developing countries. Hepatitis E vaccination is important for prevention but it influenced by the resident’s knowledge. The Qingdao residents’ knowledge of hepatitis E is still unknown. This study used online survey on the Wechat platform for investigation. Chi-square test was used to compare the hepatitis E influencing factors between subgroups. Binary
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Evaluation of prevention of mother to child transmission programme at a tertiary healthcare facility in Southwestern Nigeria Jpn. J. Infect. Dis. (IF 2.2) Pub Date : 2023-06-30 Abiodun Folashade Adekanmbi, Samuel Olufemi Akodu, Tinuade Adetutu Ogunlesi, Olusoga Babatunde Ogunfowora, Olusoji Edward Jagun, Victor Ayodeji Ayeni, Omotola Toyin Ojo, Daniel Damilare Ogbaro
Most children acquire HIV infection as a result of mother to child transmission (MTCT). The risk of MTCT of HIV is generally estimated at between 15 and 40% without prophylaxis. MTCT was responsible for approximately 370,000 infant HIV infections worldwide with Nigeria accounting for 30%. The study evaluated the effectiveness of prevention of MTCT of HIV infection programme by determining the rate
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Trends in participation in rubella antibody testing among working-aged men during annual health check-ups from 2019 to 2022 in Japan Jpn. J. Infect. Dis. (IF 2.2) Pub Date : 2023-06-30 Ai Hori, Bibha Dhungel, Satsue Nagahama
In 2019, the Japanese government set up a scheme for rubella antibody testing during workplace health check-ups for men born between fiscal years 1962 and 1978. However, use of vouchers for rubella antibody testing remains low. Health check-up data analyses are needed to determine the reason rubella antibody testing is not widely used. In this research, we aimed to clarify how rubella antibody test-taking
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Myroides odoratimimus: A New Threat with Persistent infections, Multidrug Resistance, and the Potential for Hospital Outbreaks Jpn. J. Infect. Dis. (IF 2.2) Pub Date : 2023-06-30 Ismail Selcuk Aygar, Canset Nur Aydogan, Hande Ozcan, Irem Unat, Tugba Fatsa, Kemal Tekin, Aysun Yalci, Tugrul Hosbul, Fatih Sahiner, Ramazan Gumral
Myroides species, are reported more frequently as outbreaks in clinics and intensive care units (ICUs). In this study, it is aimed to investigate the epidemic potential, antibiotic resistance profile and risk factors of the M. odoratimimus isolates, are increasingly isolated in the intensive care units (ICUs) of our hospital. Data of patients, whose Myroides spp. were isolated in their clinical specimens
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Enterovirus meningitis without pleocytosis is not only a problem in children ; A retrospective observational study in adults Jpn. J. Infect. Dis. (IF 2.2) Pub Date : 2023-06-30 Dongkeun Roh, Woochan Jeon, Jisook Lee
Reverse-transcriptase polymerase chain reaction (RT-PCR)-confirmed Enterovirus (EV) meningitis without pleocytosis has reported in only children. We examined the frequency of EV meningitis without pleocytosis and compared clinical features in adults. We retrospectively analyzed the data of adult patients with EV meningitis confirmed by cerebrospinal fluid (CSF) RT-PCR. Among 17 patients finally included
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Analysis of COVID-19 in tissues acquired by minimally invasive autopsy in out-of-hospital deaths with postmortem degeneration Jpn. J. Infect. Dis. (IF 2.2) Pub Date : 2023-06-30 Yuichiro Hirata, Yohsuke Makino, Shun Iida, Harutaka Katano, Sayaka Nagasawa, Hirofumi Rokutan, Munetoshi Hinata, Akiko Iwasaki, Yoichi Yasunaga, Hiroyuki Abe, Masako Ikemura, Ayumi Motomura, Kei Kira, Susumu Kobayashi, Shigeki Tsuneya, Suguru Torimitsu, Isao Yamamoto, Kimiko Nakagawa, Iwao Hasegawa, Shinji Akitomi, Daisuke Yajima, Tetsuo Ushiku, Hisako Saitoh, Tadaki Suzuki, Hirotaro Iwase
Minimally invasive autopsy (MIA) is an alternative to full autopsy for collection of tissue samples from patient’s bodies, using an instrument such as a biopsy needle. MIA has been conducted in many cases of coronavirus disease 2019 (COVID-19) and contributed to elucidation of the pathogenesis of the disease. However, most of these cases were hospital deaths, and there are few reports on the application
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Management of bloodborne occupational exposure among medical personnel: A 4-year prospective study Jpn. J. Infect. Dis. (IF 2.2) Pub Date : 2023-05-31 Xuxia Yu, Tieer Gan, Yuexian Zhu, Minfang Wang, Lili Qian, Ye Lu
To examine the management of bloodborne occupational exposure in a tertiary hospital in China. The prospective study was conducted at Zhejiang Hospital of Traditional Chinese Medicine between January 2016 and December 2019. Data on the blood-borne occupational exposure management was collected. A total of 460 exposures were reported. 40.22% exposures were from hepatitis B virus (HBV)-positive index
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Clinical characteristics of human pulmonary dirofilariasis in Japan: An uncommon differential diagnosis of a solitary pulmonary nodule Jpn. J. Infect. Dis. (IF 2.2) Pub Date : 2023-05-31 Kengo Oshima
Human pulmonary dirofilariasis (HPD) is a zoonosis caused by Dirofilaria immitis. Most HPD cases are asymptomatic and are either found on annual health checkups or incidentally identified during investigation of another disease, particularly primary or metastatic pulmonary lung cancer. However, the frequency of Japanese HPD and clinical features remain not well-known. We analyzed data from the Japanese
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Pulmonary coccidioidomycosis complicated by nontuberculous mycobacterial pulmonary diseases with a literature review Jpn. J. Infect. Dis. (IF 2.2) Pub Date : 2023-05-31 Hiroki Ashizawa, Naoki Iwanaga, Hirokazu Kurohama, Yuya Ito, Nobuyuki Ashizawa, Tatsuro Hirayama, Kazuaki Takeda, Shotaro Ide, Yohsuke Nagayoshi, Masato Tashiro, Takahiro Takazono, Tsutomu Tagawa, Kiyoyasu Fukushima, Masahiro Ito, Shigeki Nakamura, Koichi Izumikawa, Katsunori Yanagihara, Yoshitsugu Miyazaki, Hiroshi Mukae
Following endobronchial examination, a young mine supervisor was treated with antibiotics for a pulmonary nontuberculous mycobacterial infection for approximately 1 year. However, a review of the radiological findings, which had not been previously assessed, revealed a different possibility. Accordingly, pulmonary resection was performed, enabling histopathological analysis, which showed numerous yeast-like
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Analysis of the factors that affect the detection duration of SARS-CoV-2 in Loop Mediated Isothermal Amplification among COVID-19 inpatients Jpn. J. Infect. Dis. (IF 2.2) Pub Date : 2023-05-31 Kohei Maruyama, Kiyoshi Sekiya, Noriyuki Yanagida, Kanae Nakayama, Yusuke Kushida, Shuhei Yasuda, Daisuke Fukumoto, Satoshi Hosoya, Hiromitsu Moriya, Manabu Katsumi
In COVID-19 patients who are severe or immunocompromised, the duration of infectious viral shedding may be longer, and a longer isolation duration is recommended. In National Sagamihara hospital, a decline in the viral load to end the isolation of COVID-19 hospitalized patients is confirmed by loop mediated isothermal amplification (LAMP). However, a subset of patients persisted in displaying LAMP
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Neutralizing antibody levels and epidemiological information of patients with breakthrough COVID-19 infection in Toyama, Japan Jpn. J. Infect. Dis. (IF 2.2) Pub Date : 2023-05-31 Hideki Tani, Noriko Inasaki, Shunsuke Yazawa, Takahisa Shimada, Yumiko Saga, Hiroyasu Kaya, Yumiko Maruyama, Sadaya Matano, Hiroyuki Itoh, Tatsuhiko Kashii, Emiko Yamazaki, Masae Itamochi, Kazunori Oishi
Breakthrough infection (BI) after coronavirus disease 2019 (COVID-19) vaccination has exploded owing to the emergence of various SARS-CoV-2 variants and has become a major problem at present. In this study, we analyzed the epidemiological information and possession status of neutralizing antibodies in patients with BI using SARS-CoV-2 pseudotyped viruses (SARS-CoV-2pv). Analysis of 44 specimens diagnosed
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The ubiquitination of RIPK2 is mediated by Peli3 and negatively regulates the onset of infectious osteomyelitis Jpn. J. Infect. Dis. (IF 2.2) Pub Date : 2023-04-28 Lixiang Le, Haojie Shan, Yiwei Lin, Wenyang Xia, Xin Ma, Chaolai Jiang, Zhongmin Shi, Youjia Xu
Osteomyelitis is the infection and destruction of bone. Until now, there is no universal protocol for its treatment. Receptor-interacting serine/threonine-protein kinase 2 (RIPK2) was implicated in the development of osteomyelitis. However, its detailed mechanism remains unknown. 6-8 weeks old wild-type or Pellino E3 Ubiquitin Protein Ligase Family Member 3 (Peli3) deficiency mice were injected with
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A febrile reaction is associated with high IgG antibody titers after the second and third BNT162b2 vaccination in Japan Jpn. J. Infect. Dis. (IF 2.2) Pub Date : 2023-04-28 Nobuyasu Wakazono, Katsura Nagai, Arei Mizushima, Yukiko Maeda, Natsuko Taniguchi, Toshiyuki Harada, Emiko Satou, Nao Mae, Ken Furuya
Adverse events are potentially associated with an IgG response after the BNT162b2 vaccination for severe acute respiratory syndrome coronavirus 2. In this study, we investigated the side effects of BNT162b2 vaccination using a health questionnaire and examined its relationship with IgG antibody titers. Serum samples were collected from participants 3 months after the second vaccination, just before
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Evaluation of Pediatric Measles Cases in 2019: Single Center Experience Jpn. J. Infect. Dis. (IF 2.2) Pub Date : 2023-04-28 Mahmut Caner Us, Kübra Coci, Erkan Akkuş, Berker Okay, Gülşen Akkoç
Measles, though able to be prevented and eliminated by vaccination, is a highly contagious viral disease that can lead to serious complications, disability, and death. The aim of this study was to evaluate the characteristics of measles cases in single center. This retrospective study consecutively enrolled children who were considered to be suspicious measles cases based on their clinical features
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A nosocomial outbreak caused by human rhinovirus species A type 61 in a welfare facility in Gunma Prefecture, Japan Jpn. J. Infect. Dis. (IF 2.2) Pub Date : 2023-04-28 Ryo Shimada, Hiroyuki Tsukagoshi, Rina Kubota, Daisuke Shinoda, Yuri Shinohara, Akio Saito, Fumitaka Inoue, Tadaaki Endo, Nobuhiro Saruki
The human rhinovirus (HRV) is generally considered as the common cold and its mild symptoms’ main cause. However, HRV are also implicated in severe respiratory infections. This study reports on a nosocomial outbreak of bronchitis and pneumonia caused by HRV in a hospital during the COVID-19 epidemic in September 2022 in Gunma Prefecture, Japan. Patients continued to become infected for 9 days. During
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Can exhaled nitric oxide (FeNO) serve as a clinical indicator for patients hospitalized with Crimean-Congo Hemorrhagic Fever? Jpn. J. Infect. Dis. (IF 2.2) Pub Date : 2023-03-31 Ferhan Kerget, Buğra Kerget
Crimean-Congo Hemorrhagic Fever (CCHF), a zoonotic disease spread by infected viruses, can be a significant cause of morbidity and mortality in endemic areas. This prospective study aimed to establish a connection between exhaled nitric oxide (FeNO) levels and the clinical prognosis of CCHF. The study included a total of 85 participants: 55 patients followed for CCHF between May and August 2022 and
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Genetic characteristics of the virus detected in the first Mpox imported case in Tokyo, Japan Jpn. J. Infect. Dis. (IF 2.2) Pub Date : 2023-03-31 Fumi Kasuya, Akane Negishi, Ryota Kumagai, Isao Yoshida, Kou Murakami, Takushi Fujiwara, Michiya Hasegawa, Sachiko Harada, Arisa Amano, Makoto Inada, Sho Saito, Shinichiro Morioka, Norio Ohmagari, Yoshiyuki Sugishita, Hirofumi Miyake, Mami Nagashima, Kenji Sadamasu, Kazuhisa Yoshimura
Mpox, caused by the mpox virus (MPXV), produces symptoms similar to those of smallpox when transmitted to humans. Since 1970, this disease had been endemic mainly in Africa. However, since May 2022, the number of patients without a history of traveling to endemic areas has been globally and rapidly increasing. Under these circumstances, in July 2022, two different real-time PCR methods were used on