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CAR-T Cell Therapy in B-Cell Acute Lymphoblastic Leukemia. Mediterr. J. Hematol. Infect. Dis. (IF 3.2) Pub Date : 2024-01-01 Ugo Testa, Simona Sica, Elvira Pelosi, Germana Castelli, Giuseppe Leone
Treatment of refractory and relapsed (R/R) B acute lymphoblastic leukemia (B-ALL) is an unmet medical need in both children and adults. Studies carried out in the last two decades have shown that autologous T cells engineered to express a chimeric antigen receptor (CAR-T) represent an effective technique for treating these patients. Antigens expressed on B-cells, such as CD19, CD20, and CD22, represent
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Can we Predict Incipient Diabetes Mellitus in Patients with Transfusion Dependent β-Thalassemia (β-TDT) Referred with a History of Prediabetes? Mediterr. J. Hematol. Infect. Dis. (IF 3.2) Pub Date : 2024-01-01 Vincenzo De Sanctis, Ashraf T Soliman, Shahina Daar, Ploutarchos Tzoulis, Christos Kattamis
Prediabetes and diabetes mellitus (DM) are complications in adult patients with transfusion-dependent β-thalassemia (β-TDT), with their incidence increasing with age.
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Successful Bridging to Allogeneic Transplantation With Valemetostat in Two Refractory/relapsed Peripheral T-cell lymphoma patients. Mediterr. J. Hematol. Infect. Dis. (IF 3.2) Pub Date : 2024-01-01 Gianmarco Bagnato, Vittorio Stefoni, Alessandro Broccoli, Lisa Argnani, Cinzia Pellegrini, Beatrice Casadei, Francesca Bonifazi, Pier Luigi Zinzani
We report the case of 2 patients with relapsed/refractory peripheral T-cell lymphoma treated with valemetostat tosylate, a selective dual inhibitor of histone-lysine N-methyltransferases enhancer of zest homolog 1 and 2, and subsequently bridged to allogeneic stem cell transplantation. Valemetostat led to a quick response and was well tolerated, offering a promising bridge therapy to transplantation
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Safety of Bronchoalveolar Lavage in Hematological Patients with Thrombocytopenia. A Retrospective Cohort Study. Mediterr. J. Hematol. Infect. Dis. (IF 3.2) Pub Date : 2024-01-01 Ivan Gur, Roei Tounek, Yaniv Dotan, Elite Vainer Evgrafov, Stav Rakedzon, Eyal Fuchs
Hospitalized hematological patients often require bronchoalveolar lavage (BAL). Scarce evidence exists regarding the potential risks in patients with very severe thrombocytopenia (VST).
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Effects of Thalidomide on Erythropoiesis and Iron Homeostasis in Transfusion-Dependent β-Thalassemia. Mediterr. J. Hematol. Infect. Dis. (IF 3.2) Pub Date : 2024-01-01 Kun Yang, Xiaodong Liu, Wei Peng, Fang Hua, Lan Li, Kun Chen, Jin Zhang, Shan Luo, Wanting Li, Yuxi Ding, Jie Chen, Jian Xiao
Thalidomide is a therapeutic option for patients with β-thalassemia by increasing fetal hemoglobin and thereby reducing the requirement for blood transfusions. However, information on changes in erythropoiesis and iron homeostasis during thalidomide treatment is lacking. This study investigated the effects of thalidomide treatment on hematologic, erythropoietic, and ironstatus parameters in 22 patients
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Association between Leukemic Evolution and Uncommon Chromosomal Alterations in Pediatric Myelodysplastic Syndrome. Mediterr. J. Hematol. Infect. Dis. (IF 3.2) Pub Date : 2024-01-01 Viviane Lamim Lovatel, Beatriz Ferreira da Silva, Eliane Ferreira Rodrigues, Maria Luiza Rocha da Rosa Borges, Rita de Cássia Barbosa Tavares, Ana Paula Silva Bueno, Elaine Sobral da Costa, Terezinha de Jesus Marques Salles, Teresa de Souza Fernandez
Pediatric myelodysplastic syndrome (pMDS) is a group of rare clonal neoplasms with a difficult diagnosis and risk of progression to acute myeloid leukemia (AML). The early stratification in risk groups is essential to choose the treatment and indication for allogeneic hematopoietic stem cell transplantation (HSCT). According to the Revised International Prognostic Scoring System, cytogenetic analysis
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Plasmablastic Lymphoma. A State-of-the-Art Review: Part 1-Epidemiology, Pathogenesis, Clinicopathologic Characteristics, Differential Diagnosis, Prognostic Factors, and Special Populations. Mediterr. J. Hematol. Infect. Dis. (IF 3.2) Pub Date : 2024-01-01 Michele Bibas
This two-part review aims to present a current and comprehensive understanding of the diagnosis and management of plasmablastic lymphoma. The first section, as presented in this paper, reviews epidemiology, etiology, clinicopathological characteristics, differential diagnosis, prognostic variables, and the impact of plasmablastic lymphoma on specific populations. Plasmablastic lymphoma (PBL) is a rare
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Haploidentical Transplant with Post-Transplant Cyclophosphamide for Acute Myeloid Leukaemia and Myelodysplastic Syndromes Patients: The Role of Previous Lines of Therapy. Mediterr. J. Hematol. Infect. Dis. (IF 3.2) Pub Date : 2024-01-01 Daniele Avenoso, Fabio Serpenti, Liron Barnea Slonim, Styliani Bouziana, Francesco Dazzi, Guy Hannah, Michelle Kenyon, Varun Mehra, Austin Kulasekararaj, Pramila Krishamurthy, Mili Naresh Shah, Sharon Lionel, Antonio Pagliuca, Victoria Potter
Allogeneic haematopoietic stem-cell transplant is an option, potentially curative, for high-risk acute myeloid leukaemia (AML) and myelodysplastic syndrome (MDS) patients. Post-transplant cyclophosphamide administration allows for the selection of haploidentical donors in patients who are eligible for the procedure but do not have a fully matched donor since it can overcome the HLA barrier. There is
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CAR-T Cell Therapy for Follicular Lymphomas. Mediterr. J. Hematol. Infect. Dis. (IF 3.2) Pub Date : 2024-01-01 Ugo Testa, Francesco D'Alò, Elvira Pelosi, Germana Castelli, Giuseppe Leone
Follicular lymphoma is the second most diagnosed lymphoma in Western Europe. Significant advancements have considerably improved the survival of FL patients. However, 10-20% of these patients are refractory to standard treatments, and most of them will relapse. The treatment of follicular lymphoma patients with multiply relapsed or refractory disease represents an area of high-unmet needing new treatments
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A Rare Immune-Related Mesenteric and retroperitoneal serositis in a Multi-Refractory Hodgkin Lymphoma Patient Successfully Treated with Chylolymphostatic Surgery. Mediterr. J. Hematol. Infect. Dis. (IF 3.2) Pub Date : 2023-11-01 Matteo D'Addona,Luca Pezzullo,Corradino Campisi,Corrado Cesare Campisi,Valentina Giudice,Vincenzo Ciccone,Roberto Guariglia,Bianca Serio,Carmine Selleri
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Evaluating the Use of Meropenem in Hematologic Patients with Febrile Neutropenia: A Retrospective Observational Single-Cohort Study. Mediterr. J. Hematol. Infect. Dis. (IF 3.2) Pub Date : 2023-11-01 R A Stuurman,E Jong,P C R Godschalk,M F Corsten,J E Nagtegaal
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A Novel ALAS2 Mutation Causes Congenital Sideroblastic Anemia. Mediterr. J. Hematol. Infect. Dis. (IF 3.2) Pub Date : 2023-11-01 Yuxi Ding,Kun Yang,Xiaodong Liu,Jian Xiao,Wanting Li,Huixiu Zhong
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Impact of Sars-CoV-2 Prophylaxis with Tixagevimab-Cilgavimab in High-Risk Patients with B-Cell Malignancies: A Single-Center Retrospective Study. Mediterr. J. Hematol. Infect. Dis. (IF 3.2) Pub Date : 2023-11-01 Giovanni Manfredi Assanto,Matteo Totaro,Rebecca Poggiali,Adele Delli Paoli,Giorgia Annechini,Gianna Maria D'Elia,Francesco Aji,Luigi Petrucci,Francesca Fazio,Ilaria Del Giudice,Maurizio Martelli,Alessandra Micozzi,Giuseppe Gentile
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A Multicenter ICET-A Study on Age at Menarche and Menstrual Cycles in Patients with Transfusion-Dependent Thalassemia (TDT) who Started Early Chelation Therapy with Different Chelating Agents. Mediterr. J. Hematol. Infect. Dis. (IF 3.2) Pub Date : 2023-11-01 Salvatore Di Maio, Pierluigi Marzuillo, Shahina Daar, Christos Kattamis, Mehran Karimi, Saki Forough, Atanas Banchev, Valeria Kaleva, Soteroula Christou, Carmelo Fortugno, Polyxeni Delaporta, Ashraf T Soliman, Ploutarchos Tzoulis, Vincenzo de Sanctis
To evaluate the effect of early chelation therapy (≤ 3 years) with a variety of chelating agents on age at menarche and menstrual characteristics in patients with transfusion-dependent thalassemia (TDT).
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Diagnosis and Prognosis Evaluation of Severe Pneumonia by Lung Ultrasound Score Combined with Serum Inflammatory Markers. Mediterr. J. Hematol. Infect. Dis. (IF 3.2) Pub Date : 2023-11-01 Bo Fu, Peng Zhang, JunHua Zhang
To analyze the significance of lung ultrasound score (LUS) combined with serum inflammatory indexes in different severities of severe pneumonia and its clinical value on prognosis.
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Kinetics and Role of Pancreatic Stone Protein and Midregional Proadrenomedullin as Predictors of Sepsis and Bacteremia in Children with Hematological Malignancies. Mediterr. J. Hematol. Infect. Dis. (IF 3.2) Pub Date : 2023-11-01 Vasiliki Antari, Lemonia Skoura, Emmanuel Hatzipantelis, Vasiliki-Rengina Tsinopoulou, Konstantina Papakonstantinou, Efthimia Protonotariou, Assimina Galli-Tsinopoulou, Athanasios Tragiannidis
To investigate the kinetics and prognostic value of pancreatic stone protein (PSP) and mid-regional proadrenomedullin (MR-proADM) during episodes of febrile neutropenia (FN) in children with hematological malignancies.
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Novel Mutations in the Non-Structure Protein 2 of SARS-CoV-2. Mediterr. J. Hematol. Infect. Dis. (IF 3.2) Pub Date : 2023-11-01 Mohsen Nakhaie, Zohreh-Al-Sadat Ghoreshi, Mohammad Rezaei Zadeh Rukerd, Hedyeh Askarpour, Nasir Arefinia
Mutation in the genome of SARS-CoV-2 may play a role in immune evasion, pathogenicity, and speed of its transmission. Our investigation aimed to evaluate the mutations that exist in the NSP2.
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Therapy-Related Myeloid Neoplasms: Predisposition and Clonal Evolution. Mediterr. J. Hematol. Infect. Dis. (IF 3.2) Pub Date : 2023-11-01 Emiliano Fabiani, A Cristiano, H Hajrullaj, G Falconi, G Leone, M T Voso
Therapy-related Myeloid Neoplasm (t-MN) represents one of the worst long-term consequences of cytotoxic therapy for primary tumors and autoimmune disease. Poor survival and refractoriness to current treatment strategies characterize affected patients from a clinical point of view. In our aging societies, where newer therapies and ameliorated cancer management protocols are improving the life expectancy
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CAR-T Cell Therapy in Large B Cell Lymphoma. Mediterr. J. Hematol. Infect. Dis. (IF 3.2) Pub Date : 2023-11-01 Ugo Testa, Giuseppe Leone, Elvira Pelosi, Germana Castelli, Stefan Hohaus
Large B-cell lymphomas (LBCLs) are among the most frequent (about 30%) non-Hodgkin's lymphoma. Despite the aggressive behavior of these lymphomas, more than 60% of patients can be cured with first-line chemoimmunotherapy using the R-CHOP regimen. Patients with refractory or relapsing disease show a poor outcome even when treated with second-line therapies. CD19-targeted chimeric antigen receptor (CAR)
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Liver Disease and Sickle Cell Disease: Auto-Immune Hepatitis more than a Coincidence; A Systematic Review of the Literature. Mediterr. J. Hematol. Infect. Dis. (IF 3.2) Pub Date : 2023-11-01 Kelvin Lynch, Andrea Mega, Massimo Daves, Asma Sadiq, Helen Fogarty, Andrea Piccin
In patients with SCD, chronic liver damage is a common manifestation. More than 50% of SCD patients have elevated liver enzymes. Common underlying aetiologies include sickle cell hepatic crisis, viral hepatitis, sickle cell intrahepatic cholestasis and hepatic sequestration in the acute setting, and cholelithiasis and iron overload in the chronic setting. Autoimmune hepatitis (AIH) is a rare disease
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Bacteraemia Among Patients with Sickle Cell Disease in Nigeria: Association with Spleen Size and Function. Mediterr. J. Hematol. Infect. Dis. (IF 3.2) Pub Date : 2023-09-01 Adama I Ladu,Mairo U Kadaura,Mohammed Dauda,Abubakar Sadiq Baba,Caroline Jeffery,Abubakar Farate,Adekunle Adekile,Imelda Bates,Russell Dacombe
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Possible Involvement of Infection with Human Rhinoviruses in Children with Kawasaki Disease. Mediterr. J. Hematol. Infect. Dis. (IF 3.2) Pub Date : 2023-09-01 Ya-Wei Li,Qing Wan,Ying Cheng,Hong-Bo Hu
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Therapy-related Myeloid Neoplasms: Considerations for Patients' Clinical Evaluation. Mediterr. J. Hematol. Infect. Dis. (IF 3.2) Pub Date : 2023-09-01 Raffaele Palmieri,Giovangiacinto Paterno,Flavia Mallegni,Federica Frenza,Ilenia De Bernardis,Federico Moretti,Elisa Meddi,Maria Ilaria Del Principe,Luca Maurillo,Adriano Venditti,Francesco Buccisano
Therapy-related myeloid neoplasms (t-MNs) encompass a specific sub-group of myeloid malignancies arising after exposure to radio/cytotoxic agents for the treatment of unrelated diseases. Such malignancies present unique features, including advanced age, high comorbidities burden, and unfavorable genetic profiles. All these features justify the need for a specific diagnostic work-up and dedicated treatment
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Bacterial Infections in a Child with TD-β-thalassemia and Common Variable Immunodeficiency Due to a Novel NFKB1 Variant. Mediterr. J. Hematol. Infect. Dis. (IF 3.2) Pub Date : 2023-09-01 Wanting Li,Kun Yang,Jian Xiao,Xiaodong Liu
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A Rare Case of Multidrug-resistant Leclercia adecarboxylata Catheter-related Bloodstream Infection and an Updated Brief Literature Review. Mediterr. J. Hematol. Infect. Dis. (IF 3.2) Pub Date : 2023-09-01 Cosimo Colangelo,Giorgio Tiecco,Marco Di Gregorio,Susanna Capone,Roberto Luigi Allegri,Maria De Francesco,Francesca Caccuri,Arnaldo Caruso,Francesco Castelli,Emanuele Focà
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Correlation of Transient Elastography with Liver Iron Concentration and Serum Ferritin Levels in Patients with Transfusion-Dependent Thalassemia Major from Oman. Mediterr. J. Hematol. Infect. Dis. (IF 3.2) Pub Date : 2023-09-01 H Khan,V Panjwani,S Al Rahbi,A Eltigani,R N Qureshi,K Unissa,N Sehar,A Mittal,A V Pathare
Aims In a longitudinal study, we aimed to assess the correlation between ultrasound transient elastography (TE), serum ferritin (SF), liver iron content (LIC) by magnetic resonance imaging (MRI) T2* along with the fibrosis-4 (FIB-4) score as a screening tool to detect significant liver fibrosis among chronically transfusion-dependent beta-thalassemia (TDT) patients. Methods The study was conducted
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Hemoglobin H Disease and Growth: A Comparative Study of DHbH and NDHbH Patients. Mediterr. J. Hematol. Infect. Dis. (IF 3.2) Pub Date : 2023-09-01 Issanun Hunnuan,Kleebsabai Sanpkit,Ornsuda Lertbannaphong,Jassada Buaboonnam
Background Hemoglobin H disease (HbH), a hemoglobinopathy resulting from abnormal alpha globin genes, is classified into two categories: deletional HbH (DHbH) and non-deletional HbH (NDHbH). The alpha-mutation genotypes exhibit a range of clinical anemias, which differentially impact patient growth. Objectives This retrospective study assessed the growth of HbH patients at Siriraj Hospital, Mahidol
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Preliminary Study of sCD14 and sCD163 as Predictors of Disease Severity and ICU Admission in COVID-19: Relation to Hematological Parameters, Blood Morphological Changes and Inflammatory Biomarkers. Mediterr. J. Hematol. Infect. Dis. (IF 3.2) Pub Date : 2023-09-01 Hend Attia,Mona El Nagdy,Radwa M Abdel Halim
Background and Objectives Research supports the role of monocyte/macrophage activation in COVID-19 immunopathology. This study aimed to evaluate sCD14 and sCD163 - the monocyte activation markers - and to investigate their relation to hematological parameters and blood morphology in COVID-19 infection. Methods This is a case-control study that included 70 COVID-19 patients. Patients were subdivided
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Bone Marrow Microenvironment Involvement in t-MN: Focus on Mesenchymal Stem Cells. Mediterr. J. Hematol. Infect. Dis. (IF 3.2) Pub Date : 2023-09-01 Giulia Falconi,E Galossi,H Hajrullaj,E Fabiani,M T Voso
Therapy-related myeloid neoplasms (t-MN) are a late complication of cytotoxic therapy (CT) used in the treatment of both malignant and non-malignant diseases. Historically, t-MN has been considered to be a direct consequence of DNA damage induced in normal hematopoietic stem or progenitor cells (HSPC) by CT. However, we now know that treatment-induced mutations in HSC are not the only players involved
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Justification of Universal Iron Supplementation for Infants 6-12 months in Regions with a High Prevalence of Thalassemia. Mediterr. J. Hematol. Infect. Dis. (IF 3.2) Pub Date : 2023-09-01 Phakatip Sinlapamongkolkul,Pacharapan Surapolchai,Vip Viprakasit
Introduction Many clinicians hesitate to adopt a universal infant iron supplementation program due to the risk of increased iron absorption for those with thalassemia. We aimed to determine thalassemia prevalence in 6- to 12-month-old infants, along with the iron status of those with and without thalassemia. Methods We performed a cross-sectional descriptive study of infants attending the Well Baby
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Multiparametric Flow Cytometry in Newly Diagnosed Multiple Myeloma Patients: An Italian Monocentric Experience. Mediterr. J. Hematol. Infect. Dis. (IF 3.2) Pub Date : 2023-09-01 Francesca Fazio,Gianfranco Lapietra,Maria Zaira Limongi,Stefania Intoppa,Maria Laura Milani,Alfonso Piciocchi,Maurizio Martelli,Anna Guarini,Robin Foà,Maria Stefania De Propris,Maria Teresa Petrucci
Multiple myeloma (MM) is a heterogeneous malignancy characterized by the proliferation of abnormal plasma cells in the bone marrow. Multiparametric flow cytometry (MFC) plays a role in the work-up of the disease in view of the aberrant expression of surface antigens. Our study aimed at describing the antigenic profile detected by MFC in a series of newly diagnosed MM patients to correlate the level
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Measurement of Erythrocyte Lifespan Using a CO Breath Test in Patients with Thalassemia and the Impact of Treatment. Mediterr. J. Hematol. Infect. Dis. (IF 3.2) Pub Date : 2023-09-01 Yali Zhou,Guiping Liao,Jing Li,Manlv Wei,Linan Lu,Jingting Luo,Xiuren Jin,Shijie Yang,Lei Yang,Tianhong Zhou,Jie Huang,Yaopeng Chen,Xiaolin Yin
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Sequence Analysis of Hot Spot Regions of Spike and RNA-dependent-RNA polymerase (RdRp) Genes of SARS-CoV-2 in Kerman, Iran. Mediterr. J. Hematol. Infect. Dis. (IF 3.2) Pub Date : 2023-07-01 Nasir Arefinia, Ramin Yaghobi, Amin Ramezani, Jamal Sarvari
Mutations in the SARS-CoV-2 genome might influence pathogenicity, transmission rate, and evasion of the host immune system. Therefore, the purpose of the present study was to investigate the genetic alteration as well as assess their effects on the receptor binding domain (RBD) of the spike and the putative RNA binding site of the RdRp genes of SARS-CoV-2 using bioinformatics tools.
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TP53-Mutated Myelodysplasia and Acute Myeloid Leukemia. Mediterr. J. Hematol. Infect. Dis. (IF 3.2) Pub Date : 2023-07-01 Ugo Testa, Germana Castelli, Elvira Pelosi
TP53-mutated myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) form a distinct and heterogeneous group of myeloid malignancies associated with poor outcomes. Studies carried out in the last years have in part elucidated the complex role played by TP53 mutations in the pathogenesis of these myeloid disorders and in the mechanisms of drug resistance. A consistent number of studies has shown
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Fludarabine-Melphalan-Campath, Followed by Unmanipulated Peripheral-Blood Haematopoietic Stem Cells, Can Still Cure Lymphoma. Mediterr. J. Hematol. Infect. Dis. (IF 3.2) Pub Date : 2023-07-01 Daniele Avenoso, Amal Alabdulwahab, Michelle Kenyon, Varun Mehra, Pramila Krishnamurthy, Francesco Dazzi, Ye Ting Leung, Sandra Anteh, Mili Naresh Shah, Andrea Kuhnl, Robin Sanderson, Piers Patten, Deborah Yallop, Antonio Pagliuca, Victoria Potter
The second decade of this millennium was characterized by a widespread availability of chimeric antigen receptor T-cell (CAR-T) therapies to treat relapsed and refractory lymphomas. As expected, the role and indication of allogeneic haematopoietic stem cell transplant (allo-HSCT) in the management of lymphoma changed. Currently, a non-neglectable proportion of patients will be considered candidate
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The Mechanism of miR-155/miR-15b Axis Contributed to Apoptosis of CD34+ Cells by Upregulation of PD-L1 in Myelodysplastic Syndromes. Mediterr. J. Hematol. Infect. Dis. (IF 3.2) Pub Date : 2023-07-01 MeiWan Cao, BaoLing Peng, WanFu Xu, PeiYu Chen, HuiWen Li, Yang Cheng, Huan Chen, LiPing Ye, Jing Xie, HongLi Wang, Lu Ren, LiYa Xiong, JingNan Zhu, XiangYe Xu, LanLan Geng, SiTang Gong
Myelodysplastic syndromes (MDS) are a group of heterogeneous myeloid clonal diseases that are characterized by ineffective bone marrow hematopoiesis. Since studies have confirmed the significance of miRNAs in ineffective hematopoiesis in MDS, the current report elucidated the mechanism mediated by miR-155-5p. The bone marrow of MDS patients was collected to detect miR-155-5p and to analyze the correlation
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Fludarabine-Based Low-Intensity Conditioning for Fanconi Anemia is Associated with Good Outcomes in Aplastic Anemia but not in MDS - a Single-Center Experience. Mediterr. J. Hematol. Infect. Dis. (IF 3.2) Pub Date : 2023-07-01 Sohini Chattopadhyay, Sharon Lionel, Sushil Selvarajan, Anup J Devasia, Anu Korula, Uday Kulkarni, Fouzia Na, Eunice Sindhuvi, Kavitha M Lakshmi, Alok Srivastava, Aby Abraham, Vikram Mathews, Biju George
Hematopoietic stem cell transplantation (HSCT) is the only curative option for patients with Fanconi Anemia (FA) with hematological abnormalities.
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In vitro Activity of Cefiderocol Against Carbapenem-Resistant Acinetobacter baumannii Clinical Isolates: a Single Center Experience. Mediterr. J. Hematol. Infect. Dis. (IF 3.2) Pub Date : 2023-07-01 Angela Quirino,Claudia Cicino,Vincenzo Scaglione,Nadia Marascio,Francesca Serapide,Giuseppe Guido Maria Scarlata,Rosaria Lionello,Francesca Divenuto,Valentina La Gamba,Grazia Pavia,Alessandro Russo,Carlo Torti,Giovanni Matera,Enrico Maria Trecarichi
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High Tuberculosis Density Incidence Rate in Matched Unrelated Allogeneic Stem Cell Transplantation Recipients in the State of São Paulo, Brazil. Mediterr. J. Hematol. Infect. Dis. (IF 3.2) Pub Date : 2023-07-01 Marcelo Nóbrega Litvoc,Fabio Eudes Leal,Diogo Boldim Ferreira,Max Igor Banks Ferreira Lopes,Ligia Capuani,Vanderson Geraldo Rocha,Silvia Figueiredo Costa
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Novel RUNX1 Variation in B-cell Acute Lymphoblastic Leukemia. Mediterr. J. Hematol. Infect. Dis. (IF 3.2) Pub Date : 2023-07-01 Egzona Qipa, Muradiye Acar, Sureyya Bozkurt, Murat Buyukdogan, Hazal B Sonmez, Muge Sayitoglu, Yucel Erbilgin, Zeynep Karakaş, Veysel S Hançer
Acute lymphoblastic leukemia (ALL) is a malignant disease of hematopoietic stem cells. B cell ALL (B-ALL) is characterized by highly proliferative and poorly differentiated progenitor B cells in the bone marrow. Chromosomal rearrangements, aberrant cell signaling, and mutations lead to dysregulated cell cycle and clonal proliferation of abnormal B cell progenitors. In this study, we aimed to examine
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Routine Inflammatory Markers Are Elevated in Myelodysplastic Syndromes at Presentation. Mediterr. J. Hematol. Infect. Dis. (IF 3.2) Pub Date : 2023-07-01 Howard S Oster,Ekaterina Sklyar,Noa Golsdshmidt,Moshe Mittelman
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Gilteritinib (XOSPATA®) in Turkey: Early Access Program Results. Mediterr. J. Hematol. Infect. Dis. (IF 3.2) Pub Date : 2023-05-01 Mehmet Hilmi Dogu,Ali Irfan Emre Tekgunduz,Burak Deveci,Gulten Korkmaz,Melda Comert,Omur Gokmen Sevindik,Osman Yokus,Istemi Serin
Background And Objectives Gilteritinib (XOSPATA®, Astellas) is a type I oral FLT3 inhibitor, a tyrosine kinase AXL inhibitor, involved in both c-Kit and FMS-like tyrosine kinase 3 (FLT3) resistance. In the phase 3 ADMIRAL trial, gilteritinib was compared with the standard of care in (R/R) acute myeloid leukemia (AML) patients who harbored any FLT3 mutation and showed superior efficacy with regard to
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The Evolving Role of Haematology Nursing Practice: A Cross-Sectional Survey. Mediterr. J. Hematol. Infect. Dis. (IF 3.2) Pub Date : 2023-05-01 Sarah Liptrott,Mairéad NíChonghaile,Liz O'Connell,Erik Aerts
Background And Objectives The scope of haematology nursing practice is dynamic and must respond to advances in treatment, patients' needs and service requirements. Little is known, however, about the different roles of haematology nurses across the European setting. The purpose of this study was to identify the professional practices of haematology nurses. Method A cross-sectional online survey design
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Outcome of Patients with Diffuse Large B-Cell Lymphoma Relapsing after Autologous Transplant before Availability of CAR-T Cell Treatment. Mediterr. J. Hematol. Infect. Dis. (IF 3.2) Pub Date : 2023-05-01 Stefanie von Matt,Ulrike Bacher,Yara Banz,Behrouz Mansouri Taleghani,Urban Novak,Thomas Pabst
Introduction Autologous stem cell transplantation (ASCT) following high-dose chemotherapy is applied as salvage therapy in patients with relapsed disease or as first-line consolidation in high-risk DLBCL with chemo-sensitive disease. However, the prognosis of relapsing DLBCL post-ASCT remained poor until the availability of CAR-T cell treatment. To appreciate this development, understanding the outcome
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Prevalence of Thalassemia in the Vietnamese Population and Building a Clinical Decision Support System for Prenatal Screening for Thalassemia. Mediterr. J. Hematol. Infect. Dis. (IF 3.2) Pub Date : 2023-05-01 Danh Cuong Tran,Anh Linh Dang,Thi Ngoc Lan Hoang,Chi Thanh Nguyen,Thi Minh Phuong Le,Thi Ngoc Mai Dinh,Van Anh Tran,Thi Kim Phuong Doan,Thi Trang Nguyen
Introduction The prevalence of thalassemia among the Vietnamese population was studied, and clinical decision support systems for prenatal screening of thalassemia were created. The aim of this report was to investigate the prevalence of thalassemia in the Vietnamese population, building a clinical decision support system for prenatal screening for thalassemia. Methods A cross-sectional study was conducted
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Orbital Infiltration in a Patient with Waldenström Macroglobulinemia: Need for Multidisciplinary Approach and Comparison with the Literature. Mediterr. J. Hematol. Infect. Dis. (IF 3.2) Pub Date : 2023-05-01 Riccardo Paggi,Francesca Mariotti,Jessica Mencarini,Silvia Bresci,Irene Campolmi,Filippo Bartalesi,Beatrice Borchi,Luca Nassi,Benedetta Sordi,Alessandro Maria Vannucchi,Alessandro Bartoloni
The use of specific inhibitory drugs of intracellular signalling pathways (such as Bruton-Kinase inhibitors) for the treatment of Waldenström's macroglobulinaemia (WM) is a recognised risk factor for Aspergillus spp. infections. The overlapping clinical manifestations of the two diseases may require the involvement of different medical specialities. We describe the clinical course of a patient with
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Kaposi Sarcoma in People Living with HIV: Is it Water under the Bridge? Mediterr. J. Hematol. Infect. Dis. (IF 3.2) Pub Date : 2023-05-01 Chiara Papalini,Lucia Brescini,Laura Curci,Sabrina Bastianelli,Francesco Barchiesi,Andrea Giacometti,Daniela Francisci
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The Impact of Human Platelet Antigen Allele on Antiplatelet Antibodies and Cryoglobulins in Patients with Primary Immune Thrombocytopenia and Hepatitis C Virus-Associated Immune Thrombocytopenia. Mediterr. J. Hematol. Infect. Dis. (IF 3.2) Pub Date : 2023-05-01 Cih-En Huang,Yi-Yang Chen,Jung-Jung Chang,Yu-Ying Wu,Wei-Ming Chen,Ying-Hsuan Wang,Min-Chi Chen,Chang-Hsien Lu,Chung-Sheng Shi,Chih-Cheng Chen
Background And Objectives Human platelet antigens (HPAs) are alloantigens associated with antiplatelet alloantibodies and the risk of immune thrombocytopenia (ITP). However, few studies have investigated associations among HPAs, antiplatelet autoantibodies, and cryoglobulins. Methods We enrolled 43 patients with primary ITP, 47 with hepatitis C virus-associated ITP (HCV-ITP), 21 with hepatitis B virus-associated
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Expression and Clinical Correlation of PD-1/PD-L1 and VE1(BRAFp.V600E) in Pediatric Langerhans Cell Histiocytosis. Mediterr. J. Hematol. Infect. Dis. (IF 3.2) Pub Date : 2023-05-01 Sneha Tandon,Sheila Weitzman,Brooklyn Joyce,Bryan Mcguire,Derek Stephens,James Whitlock,Cynthia Hawkins,Bo Yee Ngan,Oussama Abla
Background And Objectives Langerhans cell histiocytosis (LCH) is an inflammatory myeloid neoplasm with a wide spectrum of clinical presentations. Programmed Cell Death-1 (PD-1) receptor and its ligand (PD-L1) are overexpressed in LCH, but their clinical significance is unknown. We performed a clinical correlation study of PD-1/PD-L1 and VE1(BRAFp.V600E) expression in 131 children with LCH. Methods
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Immune Thrombocytopenia Onset and Relapse During the COVID-19 Pandemic. A Monocenter Study. Mediterr. J. Hematol. Infect. Dis. (IF 3.2) Pub Date : 2023-05-01 Giuseppe Auteri,Simona Paglia,Camilla Mazzoni,Mattia Biondo,Marta Venturi,Andrea Davide Romagnoli,Daniela Bartoletti,Michele Cavo,Nicola Vianelli,Francesca Palandri
Background And Objectives Several infections and vaccinations can provoke immune thrombocytopenia (ITP) onset or relapse. Information on ITP epidemiology and management during the Covid-19 pandemic is scarce. In a large monocenter ITP cohort, we assessed the incidence and risk factors for: 1) ITP onset/relapse after Covid19 vaccination/infection; 2) Covid19 infection. Methods Information on the date/type
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Genetic Predisposition to Hematologic Malignancies in Childhood and Adolescence. Mediterr. J. Hematol. Infect. Dis. (IF 3.2) Pub Date : 2023-05-01 Francesco Fabozzi,Angela Mastronuzzi
Advances in molecular biology and genetic testing have greatly improved our understanding of the genetic basis of hematologic malignancies and have enabled the identification of new cancer predisposition syndromes. Recognizing a germline mutation in a patient affected by a hematologic malignancy allows for a tailored treatment approach to minimize toxicities. It informs the donor selection, the timing
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Pulmonary Actinomycosis by Actinomyces graevenitzii in Two Hematologic Patients. Mediterr. J. Hematol. Infect. Dis. (IF 3.2) Pub Date : 2023-05-01 Gabriele Facchin,Giulia Battaglia,Assunta Sartor,Carla Filì,Maria Elena Zannier,Marta Lisa Battista,Renato Fanin,Anna Candoni
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ITPA Polymorphisms and the Incidence of Toxicities in Children with Acute Lymphoblastic Leukemia. Mediterr. J. Hematol. Infect. Dis. (IF 3.2) Pub Date : 2023-03-01 Patpetra Svasdisant,Waraporn Glomglao,Preeyanun Siraprapapat,Wiyakan Inthararujikul,Kalaya Tachavanich,Chetsada Boonthimat,Sakkarin Ardsiri,Kochpinchon Chansing,Suwimon Sriprach,Sasima Tongsai,Phakatip Sinlapamongkolkul,Kleebsabai Sanpakit,Jassada Buaboonnam
Background 6-Mercaptopurine (6-MP), a thiopurine agent, is a essential medication for treating pediatric acute lymphoblastic leukemia (ALL). However, its side effects of neutropenia and hepatotoxicity might interrupt treatment, resulting in poor outcomes. Inosine triphosphate pyrophosphatase (ITPA), an enzyme in the thiopurine pathway, may prevent the accumulation of toxic thiopurine metabolites. Studies
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Levofloxacin Prophylaxis Versus no Prophylaxis in Acute Myeloid Leukemia During Post-Induction Aplasia: a Single Center Study. Mediterr. J. Hematol. Infect. Dis. (IF 3.2) Pub Date : 2023-03-01 Irene Urbino,Chiara Frairia,Alessandro Busca,Silvia Corcione,Stefano D'Ardia,Chiara Maria Dellacasa,Valentina Giai,Carolina Secreto,Roberto Freilone,Francesco Giuseppe De Rosa,Semra Aydin,Giovannino Ciccone,Rosalba Rosato,Marco Cerrano,Ernesta Audisio
Background Acute myeloid leukemia (AML) patients are at high risk of infections during post-induction neutropenia. Recently, the role of antibacterial prophylaxis has been reconsidered due to concerns about the emergence of multi-resistant pathogens. The aim of the present study was to evaluate the impact of avoiding prophylaxis on the rate of induction death (primary endpoint), neutropenic fevers
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Sickle Cell Trait, Clinical Manifestations and Outcomes: A Cross-Sectional Study in Colombia: Increasing Rate of Symptomatic Subjects Living in High Altitude. Mediterr. J. Hematol. Infect. Dis. (IF 3.2) Pub Date : 2023-03-01 Diego A Vargas-Hernández,Adriana Catalina Uscategui-Ruiz,Andrés Jesus Prada-Rueda,Consuelo Romero-Sánchez
Background Sickle cell trait (SCT) is an autosomal recessive blood disorder in which patients are heterozygous carriers for hemoglobin S (HbAS) and are usually asymptomatic. We performed a descriptive analysis of clinical manifestations and outcomes associated with SCT. Methods This was a descriptive, cross-sectional study that included patients with SCT from 2014 to 2020 at Hospital Militar Central
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Phenotypic and Molecular Detection of Biofilm Formation in Methicillin-Resistant Staphylococcus Aureus Isolated from Different Clinical Sources in Erbil City. Mediterr. J. Hematol. Infect. Dis. (IF 3.2) Pub Date : 2023-03-01 Pishtiwan Ahmad Hamad
Background Staphylococcus aureus is an important causative pathogen. The production of biofilms is an important factor and makes these bacteria resistant to antimicrobial therapy. Objectives the current study aimed to assess the prevalence of resistance to antibacterial agents and to evaluate the phenotypic and genotypic characterization of biofilm formation among S. aureus strains. Methods This study
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Achieving the Cure of Follicular Lymphoma: is it Time to Finalize Treatment Strategies to Reach This Goal in a Subset of Patients? Mediterr. J. Hematol. Infect. Dis. (IF 3.2) Pub Date : 2023-03-01 A Pulsoni,G M Assanto,M Salvatori,P Musiu,C Luise,M Passucci,G Lapietra,L Pappalardo,G Annechini,G M D'Elia,M Martelli,I Del Giudice
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Neutropenia Secondary to SARS-Cov2 Vaccination in Post-Hematopoietic Stem Cell Transplant (HSCT) Patients. Mediterr. J. Hematol. Infect. Dis. (IF 3.2) Pub Date : 2023-03-01 L M Juárez-Salcedo,S Feijóo Monroy,C García-Herce,A Alonso,B Aguado,J Ortiz,A Figuera,J R Cámara
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Quantitative Analysis of Liver Iron Deposition Based on Dual-Energy CT in Thalassemia Patients. Mediterr. J. Hematol. Infect. Dis. (IF 3.2) Pub Date : 2023-03-01 Fengming Xu,Cheng Tang,Yiling Huang,Linlin Liang,Fuling Huang,Gaohui Yang,Peng Peng
Background To explore the feasibility and accuracy of liver iron deposition based on dual-energy CT in thalassemia patients. Materials and methods 105 thalassemia patients were examined with dual-energy CT and MR liver scanning. Dual-energy CT was performed to measure CT values on 80kVp, 140kVp, and virtual iron content (VIC) imaging; ΔH was figured out by the difference in CT values between 80kVp
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Carboxyhemoglobin Levels in Preterm Neonatal Late-Onset Sepsis: to Predict or not to Predict. Mediterr. J. Hematol. Infect. Dis. (IF 3.2) Pub Date : 2023-03-01 Gonca Vardar,Eren Ozek
Background In this study, we aimed to evaluate carboxyhemoglobin (COHb) levels in diagnosing late-onset sepsis (LOS) in preterm neonates. Methods The records of culture-positive LOS in preterm neonates hospitalized in NICU from January 2017 to July 2022 were reviewed. COHb levels, C-reactive protein, procalcitonin, and neutrophil to lymphocyte ratio of septic preterm infants were compared to controls