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Navigating the waves in Colombia: a cohort study of inpatient care during four COVID-19 waves Braz. J. Infect. Dis. (IF 3.4) Pub Date : 2024-03-11 David E. Rebellón-Sánchez, Tania M. Guzmán, Sarita Rodriguez, Julio Llanos-Torres, Daniela Vinueza, Eric Tafurt, Estefanía Beltrán, Álvaro Martínez, Fernando Rosso
Understanding the intricate dynamics between different waves of the COVID-19 pandemic and the corresponding variations in clinical outcomes is essential for informed public health decision-making. Comprehensive insights into these fluctuations can guide resource allocation, healthcare policies, and the development of effective interventions. This study aimed to compare the characteristics and clinical
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GSK-3 kinase a putative therapeutic target in trypanosomatid parasites Braz. J. Infect. Dis. (IF 3.4) Pub Date : 2024-03-08 Alfredo Prado Dias, Cristian Alejandro Meneses Canal, Jaider Elian Giraldo Delgado, Ruben Eduardo Varela
Trypanosomatids are an important group of parasites that predominate in tropical and subtropical areas of the planet, which cause diseases that are classified as forgotten and neglected by the world health organization. In this group of parasites, we find and , for which there is no vaccine available, and its control has focused mainly on pharmacological treatment. Due to the poverty situation where
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SARS-CoV-2 and dialysis: humoral response, clinical and laboratory impacts before vaccination Braz. J. Infect. Dis. (IF 3.4) Pub Date : 2024-03-08 Alanna Calheiros Santos, Vanessa Duarte da Costa, Lucas Lima da Silva, Juliana Custódio Miguel, Rodrigo Jardim, Alberto Martín Rivera Dávila, Vanessa Salete de Paula, Juliana Gil Melgaço, Barbara Vieira do Lago, Livia Melo Villar
Patients with kidney disease on Hemodialysis (HD) are susceptible to Coronavirus Disease (COVID-19) due to multiple risk factors. This study aims to report the prevalence of antibodies against SARS-CoV-2 among patients on hemodialysis before vaccination in Brazil and to compare with clinical, demographic, and laboratory data. Blood samples from 398 Chronic Kidney Disease (CKD) patients treated in three
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Frailty and health-related quality of life among older people living with HIV pre- and post-COVID-19 pandemic onset: A cross-sectional study Braz. J. Infect. Dis. (IF 3.4) Pub Date : 2024-02-15 Thiago S. Torres, Jovanice S. Jesus, Daniel Arabe, Lusiele Guaraldo, Flavia Serrao Lessa, Lívia Dumont Facchinetti, Rita Estrela, Valdilea G. Veloso, Beatriz Grinsztejn, Sandra W. Cardoso
Antiretroviral therapy increased the survival and life expectancy of People living With HIV (PWH). Frailty-related syndromes among older PWH (aged 50+ years) may affect their Health-related Quality of Life (HQoL). Additionally, the COVID-19 pandemic has impacted health-related outcomes. This study aimed to estimate the prevalence of frailty and pre-frailty among older PWH, and to explore associations
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Variability in life expectancy among people with HIV in Brazil by gender and sexual orientation Braz. J. Infect. Dis. (IF 3.4) Pub Date : 2024-02-15 Paula M. Luz, Hailey Spaeth, Justine A. Scott, Beatriz Grinsztejn, Valdilea G. Veloso, Kenneth A. Freedberg, Elena Losina
In Brazil, though Antiretroviral Therapy (ART) is available to all, the benefits may not be experienced uniformly. We projected Life Expectancy (LE) for People Living with HIV (PLHIV) in care as currently observed and estimated the impact of guideline-concordant care. Using a microsimulation model, we projected LE for a cohort of PLHIV and for four population groups: cisgender Men who have Sex with
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Lack of evidence of acute HEV infections as a sexually transmitted disease: Data from a German cohort of PrEP users Braz. J. Infect. Dis. (IF 3.4) Pub Date : 2024-02-13 Guido Schäfer, Rabea Lübke, Olaf Degen, Maria Mader, Robin Scheiter, Annika Wolski, Marylyn M. Addo, Julian Schulze zur Wiesch, Sven Pischke
While the sexual transmissibility of HAV in MSM has been extensively described, the potential for sexual transmission of HEV has not been definitively established. Although HEV has been detected in the ejaculate of chronically infected men, studies among MSM PrEP users in France did not observe an elevated anti-HEV seroprevalence as an indicator of increased exposure risk by sexual intercourse. A total
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Comparative analysis of asymptomatic infection prevalence in Beta, Delta, and Omicron surges of COVID-19 Braz. J. Infect. Dis. (IF 3.4) Pub Date : 2024-02-13 Mohammad Jafari, Ahmad Jabrodini, Aliyar Pirouzi, Ahmad Meshkin, Mehdi Mohsenzadeh
The COVID-19 pandemic, caused by the SARS-CoV-2 virus, has had a devastating impact on the global population, with an estimated 650 million people infected and more than 6.6 million lives lost. Asymptomatic individuals have been shown to play a significant role in the transmission of the virus. Therefore, this study aims to investigate and compare the prevalence of asymptomatic individuals across three
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Safety of the yellow fever vaccine in people living with HIV: a longitudinal study exploring post-vaccination viremia and hematological and liver kinetics Braz. J. Infect. Dis. (IF 3.4) Pub Date : 2024-02-07 Edwiges Motta, Luiz Antonio B. Camacho, Ana M. Bispo de Filippis, Marcellus Costa, Luciana Pedro, Sandra W. Cardoso, Marta Cristina de Oliveira Souza, Ygara da Silva Mendes, Beatriz Grinsztejn, Lara E. Coelho
Safety data on the yellow fever vaccine 17DD in People Living with HIV (PLWH) are limited. This study explored the occurrence of post-vaccination 17DD viremia and the kinetics of hematological and liver laboratorial parameters in PLWH and HIV-uninfected participants [HIV(-) controls]. We conducted a secondary analysis of a longitudinal interventional trial (NCT03132311) study that enrolled PLWH and
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Six-year experience with GM test in hematological patients in a public Brazilian tertiary hospital Braz. J. Infect. Dis. (IF 3.4) Pub Date : 2024-02-06 Lucieni Oliveira Conterno, Plínio Trabasso, Mariângela Ribeiro Resende, Paula Sanches Paschoali, Leticia Bergamo Pascucci, Maria Luiza Moretti
Invasive fungal infection (IFI) is frequent in patients with hematologic malignancies or submitted hematopoietic stem cell transplantation (HSCT). To evaluate the role of the GM (galactomannan) test in prescribing therapeutic antifungals; to determine invasive aspergillosis (IA) frequency, the factors associated with positive GM test, and the in-hospital mortality. We conducted a retrospective observational
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Fully independent validation of eleven prognostic scores predicting progression to critically ill condition in hospitalized patients with COVID-19 Braz. J. Infect. Dis. (IF 3.4) Pub Date : 2024-02-06 Vinicius Lins Costa Mello, Pedro Emmanuel Alvarenga Americano do Basil
COVID-19 remains an important threat to global health and maintains the challenge of COVID-19 hospital care. To assist decision making regarding COVID-19 hospital care many instruments to predict COVID-19 progression to critical condition were developed and validated. To validate eleven COVID-19 progression prediction scores for critically ill hospitalized patients in a Brazilian population. Observational
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Comparative analysis of SARS-CoV-2 variants Alpha (B.1.1.7), Gamma (P.1), Zeta (P.2) and Delta (B.1.617.2) in Vero-E6 cells: ultrastructural characterization of cytopathology and replication kinetics Braz. J. Infect. Dis. (IF 3.4) Pub Date : 2023-12-08 Debora Ferreira Barreto Vieira, Derick Mendes Bandeira, Marcos Alexandre Nunes da Silva, Ana Luisa Teixeira de Almeida, Mia Araújo, Ana Beatriz Machado, Luis Fernando Lopez Tort, Valéria Pereira Nacife, Marilda M. Siqueira, Fernando Couto Motta, Alex Pauvolid-Corrêa, Ortrud Monika Barth
This study compares the effects of virus-cell interactions among SARS-CoV-2 variants of concern (VOCs) isolated in Brazil in 2021, hypothesizing a correlation between cellular alterations and mortality and between viral load and transmissibility. For this purpose, reference isolates of Alpha, Gamma, Zeta, and Delta variants were inoculated into monolayers of Vero-E6 cells. Viral RNA was quantified
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Rickettsia rickettsii and Rickettsia typhi in hospitalized children diagnosed with Pediatric Multisystemic Inflammatory Syndrome in Merida, Yucatan Braz. J. Infect. Dis. (IF 3.4) Pub Date : 2023-12-06 Karla Dzul-Rosado, Dayana Guadalupe Lavín-Sánchez, Gerardo Álvarez Hernández, Salvador Gómez-Carro, Fernando I. Puerto-Manzano
Multisystem Inflammatory Syndrome in Children (MIS-C) presents with fever, fatigue, elevated inflammatory markers (acute phase reactants), and a history of exposure to SARS-CoV-2 or positive antibodies to SARS-CoV-2. As the COVID-19 pandemic unfolded, the risk of MIS-C in the pediatric population increased. However, exposure to other viruses and the presence of SARS-CoV-2 positive antibodies in children
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Comparative analysis of Respiratory Syncytial Virus frequency rates and viral load in different patient cohorts in a University Hospital in São Paulo, Brazil, over an eight-year period (2005–2013) Braz. J. Infect. Dis. (IF 3.4) Pub Date : 2023-11-30 Luciano Kleber de Souza Luna, Jessica Santiago Cruz, Tânia do Socorro Souza Chaves, Nancy Bellei
Respiratory Syncytial Virus (RSV) poses a global health concern, particularly affecting young children, the elderly, and immunosuppressed individuals. RSV viral load is essential for understanding transmission, disease severity, prevention, and treatment. This retrospective study aimed to analyze the frequency rates and viral loads of RSV infections in different patient cohorts and age groups over
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The impact of COVID-19 on microbiological profile and antibiotic consumption in ICU: a retrospective study in an infectious disease hospital in Brazil Braz. J. Infect. Dis. (IF 3.4) Pub Date : 2023-12-05 Verônica de França Diniz Rocha, Euclimeire Neves da Silva, Jailton Azevedo, Marcelo Teles Ribeiro, Mitermayer Galvão Reis, Tania Fraga Barros, Joice Neves Reis
The COVID-19 pandemic has triggered crises in the public health sector that have complex and multifaceted interrelationships with antimicrobial resistance. It is important to evaluate the impact of COVID-19 on microbiological profile, antibiotic and alcohol gel consumption in Intensive Care Units (ICU). This is a retrospective study undertaken in an infectious disease hospital located in Bahia/Brazil
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Seroprevalence of viral transfusion transmissible infections (HBsAg, anti-HCV, anti-HIV, Syphilis) and coinfection among healthy volunteer blood donors during 5-years in Luanda, Angola Braz. J. Infect. Dis. (IF 3.4) Pub Date : 2023-11-27 Angelina Edna Quintas, Cláudia Camila Dias, Adis Del Carmen Cogle, Lemuel Cordeiro, António Sarmento
Background The transmission of diseases by blood products continues to be a worldwide health problem, especially in Africa. Seroprevalence rates of the Hepatitis B virus (HBV), Hepatitis C virus (HCV), Human Immunodeficiency Virus (HIV), Syphilis, and Coinfection in Angola are poorly documented. This study aims to identify the seroprevalence of markers with positive results for Hepatitis B, C, HIV
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Clinical study of hepatitis B vaccine in achieving hepatitis B surface antibody seroconversion in patients with functional cure Braz. J. Infect. Dis. (IF 3.4) Pub Date : 2023-11-27 Yisi Liu, Shan Ren, Lina Ma, Xiao Lin, Hong Li, Junfeng Lu, Zhenhuan Cao, Sujun Zheng, Zhongjie Hu, Xinyue Chen
Hepatitis B Surface Antigen (HBsAg) seroclearance is the highest treatment goal recommended by the current guidelines for hepatitis B. Levels of antibodies to HBsAg (anti-HBs) are strongly associated with HBsAg recurrence, but hepatitis B vaccination may increase the anti-HBs seroconversion rate and reduce recurrence. We conducted a retrospective clinical study to ascertain the effect of this vaccination
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Emphysematous cystitis: A rare form of urinary tract infection Braz. J. Infect. Dis. (IF 3.4) Pub Date : 2023-11-17 Louise Cavalcanti Salles, Tacilla Hanny de Souza Andrade, Rafael Siqueira Athayde Lima, Geraldo Bezerra da Silva Junior
Abstract not available
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Bartonella henselae as a putative trigger for chronic type 2 leprosy reactions Braz. J. Infect. Dis. (IF 3.4) Pub Date : 2023-11-17 Luciene Silva dos Santos, Marina Rovani Drummond, Isabela Maria Bernardes Goulart, Andrea Fernandes Eloy da Costa França, Elemir Macedo de Souza, Paulo Eduardo Neves Ferreira Velho
Leprosy reactions are an acute inflammatory phenomenon that can arise before diagnosis, during treatment, or after cure of leprosy. These reactions are considered one of the main diseases that cause physical disabilities. Immunosuppressive treatment for these immune responses makes these patients susceptible to coinfections, which can trigger new leprosy reactions. The main objective of this study
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Sensitivity and specificity of a syphilis rapid diagnostic test in blood donors’ samples Braz. J. Infect. Dis. (IF 3.4) Pub Date : 2023-11-14 Carolina Arai, Juliano Alves Lemos-Machado, Marcelo Vivolo Aun, Carolina Bonet-Bub, Leandro Dinalli Santos, Angelica Espinosa Miranda, Vivian I. Avelino-Silva
Rapid Diagnostic Tests (RDT) are useful to identify syphilis cases, particularly for hard-to-reach populations and if laboratory services are scarce. However, RDT performance may be suboptimal. We aimed to assess the sensitivity and specificity of a syphilis RDT using well-characterized blood donors’ samples. We categorized samples from 811 blood donors into five groups: 1 - Samples with reactive Chemiluminescence
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Multidrug-resistant Acinetobacter spp. from hospital intensive care units in Brazilian Amazon Braz. J. Infect. Dis. (IF 3.4) Pub Date : 2023-11-14 Marcos Eduardo Passos da Silva, Maicon Aleandro da Silva Gomes, Renata Santos Rodrigues, Nucia Cristiane da Silva Lima, Anjo Gabriel Carvalho, Roger Lafontaine Mesquita Taborda, Najla Benevides Matos
Acinetobacter spp. are one of the main pathogens responsible for healthcare-associated infections and are associated with high rates of morbidity and mortality globally, mainly because of their high capacity to present and develop resistance to antimicrobials. To identify species of the Acinetobacter and their resistance profiles from samples collected from hospitalized patients, health professionals
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Pharmacokinetics and therapeutic target attainment of vancomycin in pediatric post-liver transplant patients Braz. J. Infect. Dis. (IF 3.4) Pub Date : 2023-11-14 Ronaldo Morales Junior, Vanessa D'Amaro Juodinis, Daniela Carla de Souza, Silvia Regina Cavani Jorge Santos
Introduction Vancomycin is widely prescribed to treat or prevent Gram-positive infections in pediatric liver transplant recipients. The objective of this prospective cohort study is to describe vancomycin pharmacokinetics and to evaluate the therapeutic target attainment after initial dose regimen. Materials and methods Patients with previous renal injury were excluded. Vancomycin therapy started
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Investigation of etiology of community-acquired pneumonia in hospitalized patients in a tertiary hospital of São Paulo City, Brazil Braz. J. Infect. Dis. (IF 3.4) Pub Date : 2023-11-13 Daniel Joelsons, Cecília Salete Alencar, João Renato Rebello Pinho, Yeh-Li Ho
Background Community-Acquired Pneumonia (CAP) is the primary cause of hospitalization in the United States and the third leading cause of death in Brazil. The gold standard for diagnosing the etiology of CAP includes blood culture, Gram-stained sputum, and sputum culture. However, these methods have low sensitivity. No studies investigating the etiology of CAP have been conducted in Brazil in the last
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Seroprevalence and indexes of IgG antibodies for SARS-CoV-2 infection among People Living With HIV, tuberculosis patients and healthcare workers, in Salvador, Brazil Braz. J. Infect. Dis. (IF 3.4) Pub Date : 2023-10-06 Daniele Souza de Santana, Eduardo Martins Netto, Sara Nunes Vaz, Paulo Henrique Dantas, Carlos Brites
Introduction COVID-19 can trigger different clinical presentations in distinct population groups, some of which are considered at higher risk of SARS-CoV-2 infection. Little is known about the susceptibility of certain populations to the infection. Objectives We aimed to determine the prevalence of COVID-19 among People Living With HIV/AIDS (PLWH) attending a tertiary public hospital in Salvador, Brazil
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Bacterial keratitis in a tertiary hospital in São Paulo: a 21-year review of the epidemiological, laboratory, and clinical data Braz. J. Infect. Dis. (IF 3.4) Pub Date : 2023-10-06 Beatriz Avila Zaccaron, Maria Emilia Xavier dos Santos Araújo, Alexandre Inácio Cruz de Paula, Bruno de Mendonça Costa, Emellyne Pamela Diniz Pires Papalini, Roberta Arb Saba Rodrigues Pinto
Infectious keratitis is a sight-threatening condition that is usually an ocular emergency. The visual outcome depends on prompt and accurate clinical management as well as geographic and epidemiological awareness. We conducted a retrospective observational study to define the epidemiological and laboratory profile, as well as the clinical course of bacterial keratitis in a tertiary hospital in São
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Survival analysis over a 20-year period of a Brazilian cohort of blood donors coinfected HIV-HCV Braz. J. Infect. Dis. (IF 3.4) Pub Date : 2023-10-06 Hélio Ranes de Menezes Filho, Giuliano Grandi, Ludimila Paula Vaz Cardoso, Juan Felipe Galvão da Silva, Soraia Mafra Machado, Cesar de Almeida-Neto, Ester Cerdeira Sabino, Maria Cássia Mendes-Corrêa
Among individuals coinfected with HCV and HIV, studies of mortality from non-hepatic causes have shown inconsistent results. The aim of this study was to investigate the contribution of HCV and HIV co-infection to mortality from hepatic and non-hepatic causes in Brazil. This retrospective cohort study included blood donors from Fundação Pró-Sangue de São Paulo (FPS) who were followed from 1994 to 2016
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Weight gain in patients starting Dolutegravir-based ART according to baseline CD4 count after 48 weeks of follow up Braz. J. Infect. Dis. (IF 3.4) Pub Date : 2023-09-30 Érico C. Cardoso-Neto, Eduardo Martins Netto, Carlos Brites
Background Excessive weight gain is a current concern among People Living with HIV (PLHIV) starting ART. Objectives To evaluate the weight gain after 48-weeks of ART in naive patients, according with baseline CD4 count. Methods PLHIV starting 3TC + TDF + DTG with at least 48-weeks of follow up in two AIDS referral centers were stratified by baseline CD4 count (lower or higher than 200 cells/mm3). Data
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Nocardiosis: a single-center experience and literature review Braz. J. Infect. Dis. (IF 3.4) Pub Date : 2023-10-03 Bruno Besteiro, Daniel Coutinho, Joana Fragoso, Cristóvão Figueiredo, Sofia Nunes, Carlos Azevedo, Tiago Teixeira, Aurélia Selaru, Gabriela Abreu, Luís Malheiro
Introduction Nocardiosis is a rare bacterial infection caused by Nocardia spp. However, an increasing incidence has been described whereby data about epidemiology and prognosis are essential. Methods A retrospective descriptive study was conducted among patients with positive Nocardia spp. culture, from January 2019 to January 2023, at a Terciary Hospital in Portugal. Results Nocardiosis was considered
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Could well-established, widely available, and simple laboratory techniques explain a laboratory origin of SARS-CoV-2? Braz. J. Infect. Dis. (IF 3.4) Pub Date : 2023-10-03 Robert M. Lloyd Jr, James R. Hunter, Ricardo Sobhie Diaz, Mauro Schechter
Abstract not available
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Efficacy and safety of preemptive therapy for cytomegalovirus end-organ disease in people living with HIV: a systematic review and meta-analysis Braz. J. Infect. Dis. (IF 3.4) Pub Date : 2023-09-27 Cándida Díaz-Brochero, Laura Cristina Nocua-Báez, Martha Carolina Valderrama-Rios, Jorge Alberto Cortés
Introduction Cytomegalovirus end-organ-disease (CMV EOD) is still a major cause of debilitating illness in people living with HIV, especially in developing countries. Objective To evaluate the efficacy and safety of preemptive therapy against CMV EOD in HIV-positive adults with CMV viremia. Methods Systematic review of clinical trials by searching electronic databases and clinical trial registries
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Real-time PCR in the diagnosis of congenital toxoplasmosis Braz. J. Infect. Dis. (IF 3.4) Pub Date : 2023-09-21 Bianca Balzano De La Fuente Villar, Leonardo Henrique Ferreira Gomes, Elyzabeth Avvad Portari, Carla Nasser Patrocinio Ramos, Danielle Nascimento Rocha, José Paulo Pereira, Elizabeth de Souza Neves, Letícia da Cunha Guida
The diagnosis of congenital toxoplasmosis presents limitations and therefore new options are necessary. The analysis of amniotic fluid by real-time PCR has already proved effective for confirmation of fetal infection. However, its performance in other biological samples is not clear yet. The aim of this study is to better understand the role of real-time PCR in the blood of the mother and newborn as
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Significance of Aspergillus spp. isolation in defining cases of COVID-19 Associated Pulmonary Aspergillosis – CAPA Braz. J. Infect. Dis. (IF 3.4) Pub Date : 2023-07-25 Tiago Alexandre Cocio, Lumena Pereira Machado Siqueira, Katie Cristina Takeuti Riciluca, Viviane Mazo Favero Gimenes, Tânia Sueli de Andrade, Gil Benard, Roberto Martínez, Valdes Roberto Bollela
COVID-19-Associated Pulmonary Aspergillosis (CAPA) is a relatively common complication in patients with severe forms of the disease caused by the SARS-CoV-2 virus. Diagnosing and confirming CAPA is challenging. In this study, Aspergillus spp. isolation in respiratory specimens from patients with COVID-19 was evaluated for identifying cases of CAPA. In 2020‒2021, 17 Aspergillus spp. were isolated from
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Cohort study of hospitalized patients with COVID-19 at Brazilian tertiary-care hospital: Occurrence of adverse events and mortality Braz. J. Infect. Dis. (IF 3.4) Pub Date : 2023-07-25 Maitê Vasconcelos Luz, Julian Furtado Silva, Hugo Dugolin Ceccato, Paulo José de Souza Júnior, Pedro Maximink Villar, Paulo Roberto Araújo Mendes, Mariângela Ribeiro Resende, Mônica Corso Pereira, Lucieni Oliveira Conterno
Introduction Patients hospitalized with COVID-19 are often submitted to invasive procedures and they are at risk for hospital-associated adverse events. Objectives To evaluate the epidemiological and clinical aspects of patients hospitalized with COVID-19; the occurrence of adverse events and the risk factors for mortality. Method Cohort study that included adult patients hospitalized with a diagnosis
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Factors associated with Trichomonas vaginalis infection in reproductive-aged women attending cervical screening in southeast of Brazil Braz. J. Infect. Dis. (IF 3.4) Pub Date : 2023-07-25 Gabriel Vitor da Silva Pinto, Aline do Nascimento Bolpet, Laura Fernandes Martin, Natália Prearo Moço, Bruna Ribeiro de Andrade Ramos, Mariana de Castro Silva, Marli Teresinha Casamassimo Duarte, Andréa da Rocha Tristão, Márcia Guimarães da Silva, Camila Marconi
Background Sexually Transmitted Infections (STIs) can be caused by viruses, bacteria, and parasites. The World Health Organization estimated more than 300 million new global cases of curable STIs among individuals of reproductive age. Infection by Trichomonas vaginalis is one of the most prevalent curable STI. Despite the current treatments available, the diagnosis of T. vaginalis can be difficult
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Peritonitis caused by paracoccidioides spp. in a patient on continuous ambulatory peritoneal dialysis – A case report Braz. J. Infect. Dis. (IF 3.4) Pub Date : 2023-07-22 Lázaro Bruno Borges Silva, Mariângela Ottoboni Brunaldi, Roberto Martinez, José Abrão Cardeal da Costa
Paracoccidioidomycosis is a systemic mycosis found mainly in South America and is the most prevalent endemic and systemic mycosis in Brazil. The purpose of this paper was to report the case of a male patient who developed peritonitis caused by Paracoccidioides spp. Forty-eight-year-old, male patient, with type I Diabetes mellitus and chronic kidney disease who was undergoing a Continuous Ambulatory
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Accuracy of a raw saliva-based COVID-19 RT-LAMP diagnostic assay Braz. J. Infect. Dis. (IF 3.4) Pub Date : 2023-07-19 Kátia Maria dos Santos Cabral, Ramon Cid Gismonti Baptista, Terezinha Marta Pereira Pinto Castineiras, Amilcar Tanuri, Fabiana Avila Carneiro, Marcius da Silva Almeida, Monica Montero-Lomeli
The Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) pandemic demanded rapid diagnosis to isolate new COVID-19 cases and prevent disease transmission. Quantitative Real-Time Polymerase Chain Reaction (qRT-PCR) rapidly became the gold standard for diagnosis. However, due to the high cost and delay of the results, other types of diagnosis were implemented, such as COVID-19 Ag Rapid Tests
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Latin America in the clutches of an old foe: Dengue Braz. J. Infect. Dis. (IF 3.4) Pub Date : 2023-07-10 Marcel Alied, Patricia Takako Endo, Victor Hugo Aquino, Venkata Vasavi Vaddur, Nguyen Tien Huy
Abstract not available
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Pulmonary function and exercise capacity six months after hospital discharge of patients with severe COVID-19 Braz. J. Infect. Dis. (IF 3.4) Pub Date : 2023-07-10 Jessica Polese, Alessandro Demoner Ramos, Isac Ribeiro Moulaz, Larissa Sant'Ana, Bárbara Sthefany de Paula Lacerda, Cinthia Eduarda Santos Soares, Karen Evelin Monlevade Lança, Beatriz Paoli Thompson, Germano Paulo Barbosa Júnior, Isabella Izaita Polese Pinto, José Geraldo Mill
Introduction The long-term consequences of COVID-19, especially pulmonary impairment, are frequent but not well understood. The knowledge about sequels or long COVID-19 are necessary, considering the high prevalence and need for specific public strategies. Method The study was conducted to evaluate symptoms (standardized questionnaire), pulmonary function (spirometry), and exercise capacity (6-minute-walk-test)
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Brazil needs to be vaccinated Braz. J. Infect. Dis. (IF 3.4) Pub Date : 2023-06-27 Leonardo Weissmann, Rosana Richtmann
Abstract not available
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Reproductive health syndemics impact retention in care among women living with HIV in Rio de Janeiro, Brazil Braz. J. Infect. Dis. (IF 3.4) Pub Date : 2023-05-22 Christine M. Zachek, Lara E. Coelho, Jesse L. Clark, Rosa M.S.M. Domingues, Paula M. Luz, Ruth K. Friedman, Ângela C. Vasconcelos de Andrade, Valdilea G. Veloso, Jordan E. Lake, Beatriz Grinsztejn, Raquel B. De Boni
Syndemic psychosocial and reproductive factors affecting women's retention in HIV care remain understudied. We analyzed correlates of non-retention in a cohort of women with HIV in Brazil from 2000‒2015. Participants self-reported exposure to physical/sexual violence, illicit drug use, adolescent pregnancy, or induced abortion. Lifetime history of these psychosocial stressors were used to create a
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COVID-19 in real world: Survival and medical costs of hospitalized patients in Brazil´s first wave Braz. J. Infect. Dis. (IF 3.4) Pub Date : 2023-05-15 Jaime Luís Lopes Rocha, Irina Riediger, Juliano Gasparetto, Felipe Francisco Tuon
Objective To evaluate survival and direct medical costs of patients admitted in private hospitals with COVID-19 during the first wave. Methods A retrospective, observational study analyzing survival and the economic data retrieved on hospitalized patients with COVID-19. Data from March 2020 to December 2020. The direct cost of hospitalization was estimated using the microcosting method with each individual
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Conserved multiepitope vaccine constructs: A potent HIV-1 therapeutic vaccine in clinical trials Braz. J. Infect. Dis. (IF 3.4) Pub Date : 2023-05-05 Elahe Akbari, Masoud Seyedinkhorasani, Azam Bolhassani
Despite the success of Antiretroviral Therapy (ART) in preventing HIV-1-associated clinical progression to AIDS, it is unable to eliminate the viral reservoirs and eradicate the HIV-1 infection. Therapeutic vaccination is an alternative approach to alter the HIV-1 infection course. It can induce effective HIV-1-specific immunity to control viremia and eliminate the need for lifelong ART. Immunological
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Tapeworm (Diphyllobothrium nihonkaiense) detected by abdominal ultrasonography Braz. J. Infect. Dis. (IF 3.4) Pub Date : 2023-05-05 Ryota Hase, Haruki Mito, Yudai Yano, Yasuyuki Morishima, Yuichi Hasegawa
Abstract not available
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In vitro activity of imipenem/relebactam against non-Morganellaceae Enterobacterales and Pseudomonas aeruginosa in Latin America: SMART 2018‒2020 Braz. J. Infect. Dis. (IF 3.4) Pub Date : 2023-05-08 James A. Karlowsky, Sibylle H. Lob, Fakhar Siddiqui, Jacqueline Pavia, C. Andrew DeRyke, Katherine Young, Mary R. Motyl, Daniel F. Sahm
Carbapenem-resistant Enterobacterales and Pseudomonas aeruginosa are being isolated from patient specimens with increasing frequency in Latin America and worldwide. The current study provides an initial description of the in vitro activity of imipenem/relebactam (IMR) against non-Morganellaceae Enterobacterales (NME) and P. aeruginosa infecting hospitalized patients in Latin America. From 2018 to 2020
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Can the data of microbiome be used to predict the presence of Burkholderia spp in pulmonary microbiota of cystic fibrosis patients? Braz. J. Infect. Dis. (IF 3.4) Pub Date : 2023-05-05 Fabiana Caroline Zempulski Volpato, Otávio von Ameln Lovison, Daiana de Lima-Morales, Andreza Francisco Martins, Paulo José Cauduro Maróstica, Afonso Luís Barth
Abstract not available
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Myeloperoxidase as a biomarker for intestinal-brain axis dysfunction induced by malnutrition and Cryptosporidium infection in weanling mice Braz. J. Infect. Dis. (IF 3.4) Pub Date : 2023-05-05 Reinaldo B. Oriá, Deiziane V.S. Costa, Pedro Henrique Q.S. de Medeiros, Cássia R. Roque, Ronaldo P. Dias, Cirle A. Warren, David T. Bolick, Richard L. Guerrant
Cryptosporidiosis is a waterborne protozoal infection that may cause life-threatening diarrhea in undernourished children living in unsanitary environments. The aim of this study is to identify new biomarkers that may be related to gut-brain axis dysfunction in children suffering from the malnutrition/infection vicious cycle is necessary for better intervention strategies. Myeloperoxidase (MPO) is
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Verrucous tungiasis - image and clinical findings in a patient with an exuberant case Braz. J. Infect. Dis. (IF 3.4) Pub Date : 2023-04-26 Renata Freire Luna, Adryadne da Silva Adolfs, Virginia Vilasboas Figueiras, Marilaine Martins, Luciana Mendes dos Santos
Abstract not available
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Mobility restrictions during the COVID-19 pandemic and reduced outpatient HIV and syphilis testing in Brazil Braz. J. Infect. Dis. (IF 3.4) Pub Date : 2023-04-17 Gabriel J. Seara-Morais, Bruna F. Pousada, Fábio F. Escaleira, André Mario Doi, Eliane Aparecida Rosseto Welter, Vivian I. Avelino-Silva
Background In the initial phases of the COVID-19 pandemic, strategies adopted to reduce the dissemination of SARS-CoV-2 relied on non-pharmacological interventions, including physical distancing. Mobility restrictions affected the availability and quality of care for many health conditions, including sexually transmitted infections. Objective To investigate the impact of the COVID-19 pandemic mobility
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Factors associated with bacterial vaginosis in women with homosexual, bisexual and heterosexual practices Braz. J. Infect. Dis. (IF 3.4) Pub Date : 2023-03-26 Mariana Alice de Oliveira Ignacio, Thayná Santos Buesso, Julia Andrade Pessoa Morales, Mariana de Castro Silva, Marcia Guimaraes da Silva, Marli Teresinha Cassamassimo Duarte
Background The factors associated with bacterial vaginosis in women with homosexual, bisexual and heterosexual practices are still poorly explored. Thus, the aim of this study was to analyze the factors associated with bacterial vaginosis in women with different sexual practices. Methods Cross-sectional study that included 453 women, 149 Women with Homosexual practice (WSW); 80 bisexual Women (WSWM)
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Cystic pneumonia in a patient with AIDS Braz. J. Infect. Dis. (IF 3.4) Pub Date : 2023-03-25 Vincent Guiraud, Simon Bessis
Abstract not available
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Epidemiology and in vitro activity of ceftazidime-avibactam and comparator agents against multidrug-resistant isolates of Enterobacterales and Pseudomonas aeruginosa collected in Latin America as part of the ATLAS surveillance program in 2015‒2020 Braz. J. Infect. Dis. (IF 3.4) Pub Date : 2023-03-25 Mark G. Wise, James A. Karlowsky, Elkin V. Lemos-Luengas, Rafael R. Valdez, Daniel F. Sahm
Introduction The incidence of antimicrobial resistance is increasing in many parts of the world. The focus of this report is to examine changes in antimicrobial resistance epidemiology among clinical isolates of Enterobacterales and Pseudomonas aeruginosa collected in six Latin American countries as part of the Antimicrobial Testing Leadership and Surveillance (ATLAS) program from 2015 to 2020, with
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Lamivudine-based two-drug regimens with dolutegravir or protease inhibitor: Virological suppression in spite of previous therapy failure or renal dysfunction Braz. J. Infect. Dis. (IF 3.4) Pub Date : 2023-02-19 Elaine Monteiro Matsuda, Ivana Barros Campos, Isabela Penteriche de Oliveira, Daniela Rodrigues Colpas, Giselle Ibete Silva López-Lopes, Victor Oliveira Chiavegato, Luís Fernando de Macedo Brígido
Background Two-Drug Regimens (2DR) have proven effective in clinical trials but real-world data, especially in resource-limited settings, is limited. Objectives To evaluate viral suppression of lamivudine-based 2DR, with dolutegravir or ritonavir-boosted protease inhibitor (lopinavir/r, atazanavir/r or darunavir/r), among all cases regardless of selection criteria. Patients and methods A retrospective
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Prevalence of bloodstream infection pathogens in hemato-oncological patients and predictors of carbapenem-resistant gram-negative bacterial infections during febrile neutropenia Braz. J. Infect. Dis. (IF 3.4) Pub Date : 2023-02-18 Ana Paula Schonardie, Eduarda Beck, Maria Helena Rigatto
Background Carbapenem-Resistant Gram-Negative (CRGN) Bloodstream Infections (BSI) represent a therapeutic challenge, especially in the context of Febrile Neutropenia (FN) in cancer patients. Methods We characterized pathogens causing BSI in patients aged ≥18 years who had undergone systemic chemotherapy for solid or hematological cancers between 2012 and 2021 in Porto Alegre, Brazil. Predictors of
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Chronic medical conditions associated with invasive pneumococcal diseases in inpatients in teaching hospitals in São Paulo city: Estimating antimicrobial susceptibility and serotype-coverage of pneumococcal vaccines Braz. J. Infect. Dis. (IF 3.4) Pub Date : 2023-02-06 Renato A. Kfouri, Maria-Cristina C. Brandileone, Marco Aurélio P. Sáfadi, Rosana Richtmann, Alfredo E. Gilio, Flavia Rossi, Thais Guimarães, Ana Luiza Bierrenbach, José C. Moraes
Background Chronic conditions increase the risk of invasive pneumococcal diseases (IPD). Pneumococcal vaccination remarkably reduced IPD morbimortality in vulnerable populations. In Brazil, pneumococcal vaccines are included in the National Immunization Program (PNI): PCV10 for < 2 years-old, and PPV23 for high risk-patients aged ≥ 2 years and institutionalized ≥ 60 years. PCV13 is available in private
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Mortality rates by gender and sexual orientation reveal a disproportionally high mortality among cisgender men of unknown sexual orientation and men who have sex with women in a cohort of people living with HIV in Rio de Janeiro, Brazil Braz. J. Infect. Dis. (IF 3.4) Pub Date : 2023-01-31 Lara E. Coelho, Thiago S. Torres, Emilia M. Jalil, Sandra W. Cardoso, Ronaldo I. Moreira, Guilherme A. Calvet, Antônio G. Pacheco, Valdiléa G. Veloso, Beatriz Grinsztejn, Paula M. Luz
Background Antiretroviral therapy use has led to a decline in HIV-related mortality yet disparities by gender and/or sexual orientation may exist. In this study, we estimated hazards of death in people living with HIV (PLWH) according to gender and sexual orientation. Methods We included PLWH ≥ 18 years enrolled between 2000 and 2018 at INI/Fiocruz, Rio de Janeiro, Brazil. Participants were grouped
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Safety of levofloxacin as an antibiotic prophylaxis in the induction phase of children newly diagnosed with acute lymphoblastic leukemia: an interim analysis of a randomized, open-label trial in Brazil Braz. J. Infect. Dis. (IF 3.4) Pub Date : 2023-02-05 Mauro Cesar Dufrayer, Ciliana Rechenmacher, Clarice Franco Meneses, Yasmine Massaro Carneiro Monteiro, Fabianne Altruda de Moraes Costa Carlesse, Fabrizio Motta, Liane Esteves Daudt, Mariana Bohns Michalowski
Background Despite high cure rates, treatment-related mortality in children with acute lymphoblastic leukemia (ALL) remains significant. About 4% of patients die during remission induction therapy and approximately two-thirds of treatment-related deaths are due to infectious complications. Methods From May 2021 to June 2022, children aged one through 18 years, with a recent diagnosis of ALL, admitted
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Pediatric case of septic arthritis due to Streptococcus pneumoniae serotype 19A Braz. J. Infect. Dis. (IF 3.4) Pub Date : 2023-01-31
In recent years, the incidence of pediatric septic arthritis caused by Streptococcus pneumoniae has been quite low. The pneumococcal conjugate vaccine PCV10 is the available vaccine included in the Bulgarian national immunization program. PCV10 reduces the incidence of invasive diseases, but non-vaccinal serotypes like 19A, the etiologic agent of the case of septic arthritis reported herein in a 3-year-old
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Cutaneous Leishmaniasis presenting as an exuberant forehead lesion Braz. J. Infect. Dis. (IF 3.4) Pub Date : 2023-02-02 Ingrid Reuwsaat Paul, Bruna Molozzi, Gustavo Moreira Amorim
Abstract not available
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Epoxy-α-lapachone (2,2-Dimethyl-3,4-dihydro-spiro[2H-naphtho[2,3-b]pyran-10,2′-oxirane]-5(10H)-one): a promising molecule to control infections caused by protozoan parasites Braz. J. Infect. Dis. (IF 3.4) Pub Date : 2023-01-31 Juliana Figueiredo Peixoto, Adriane da Silva Oliveira, Luiz Filipe Gonçalves - Oliveira, Franklin Souza - Silva, Carlos Roberto Alves
Natural products and their derivatives have been sources of search and research for new drugs for the treatment of neglected diseases. Naphthoquinones, a special group of quinones, are products of natural metabolites with a wide spectrum of biological activities and represent a group of interesting molecules for new therapeutic propositions. Among these compounds, lapachol stands out as a molecule
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Systemic infection caused by the methicillin-resistant Staphylococcus aureus USA300-LV lineage in a Brazilian child previously colonized Braz. J. Infect. Dis. (IF 3.4) Pub Date : 2023-01-03 Carolina de Oliveira Whitaker, Raiane Cardoso Chamon, Tamara Lopes Rocha de Oliveira, Simone Aranha Nouér, Kátia Regina Netto dos Santos
The methicillin-resistant Staphylococcus aureus (MRSA) USA300-Latin American variant (USA300-LV) lineage is well documented in northern Latin American countries. It has replaced established clones in hospital environments. We herein report a systemic infection caused by a USA300-LV isolate in a 15-year-old boy, from a low-income area of Rio de Janeiro, previously colonized by the same strain. During
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Protease inhibitors as a potential agent against visceral Leishmaniasis: A review to inspire future study Braz. J. Infect. Dis. (IF 3.4) Pub Date : 2023-01-03 Veena Sreedharan, K.V. Bhaskara Rao
Leishmaniasis is transmitted by sandfly which carries the intracellular protozoa in their midgut. Among visceral, cutaneous and mucocutaneous leishmaniasis, visceral type that is caused by Leishmania donovani is the most lethal one. Findings of leishmanial structure and species took place in 19th century and was initiated by Donovan. Leishmaniasis is still a major concern of health issues in many endemic