-
Comparative Effectiveness of mRNA-1273 and BNT162b2 COVID-19 Vaccines Among Older Adults: Systematic Literature Review and Meta-Analysis Using the GRADE Framework Infect. Dis. Ther. (IF 5.4) Pub Date : 2024-03-18 Sushma Kavikondala, Katrin Haeussler, Xuan Wang, Mary T. Bausch-Jurken, Maria Nassim, Nitendra Kumar Mishra, Mia Malmenäs, Pawana Sharma, Nicolas Van de Velde, Nathan Green, Ekkehard Beck
-
Estimation of Symptomatic Respiratory Syncytial Virus Infection Incidence in Adults in Multiple Countries: A Time-Series Model-Based Analysis Protocol Infect. Dis. Ther. (IF 5.4) Pub Date : 2024-03-18 Robin Bruyndonckx, Aleksandra Polkowska-Kramek, Caihua Liang, Charles Nuttens, Thao Mai Phuong Tran, Bradford D. Gessner, Elizabeth Begier
Introduction Estimating respiratory syncytial virus (RSV) burden in adults is challenging because of non-specific symptoms, infrequent standard-of-care testing, resolution of viral shedding before seeking medical care, test positivity that varies by specimen site in the upper airway and lower diagnostic test sensitivity compared to children. Conducting prospective observational studies to assess RSV
-
Best Practices for Identifying Hospitalized Lower Respiratory Tract Infections Using Administrative Data: A Systematic Literature Review of Validation Studies Infect. Dis. Ther. (IF 5.4) Pub Date : 2024-03-18 Germaine Hanquet, Christian Theilacker, Jeffrey Vietri, Ingrid Sepúlveda-Pachón, Sonia Menon, Bradford Gessner, Elizabeth Begier
-
Evaluating the Demand for Nucleic Acid Testing in Different Scenarios of COVID-19 Transmission: A Simulation Study Infect. Dis. Ther. (IF 5.4) Pub Date : 2024-03-18 Yu-Yuan Wang, Wei-Wen Zhang, Ze-xi Lu, Jia-lin Sun, Ming-xia Jing
-
Modelling the Public Health Burden of Herpes Zoster and the Impact of Adjuvanted Recombinant Zoster Vaccine in Five Selected Countries in Southeast Asia Infect. Dis. Ther. (IF 5.4) Pub Date : 2024-03-17
Abstract Introduction Herpes zoster (HZ) can cause substantial patient morbidity and lead to large healthcare costs. However, the disease burden of HZ in Southeast Asia may be underestimated. This study aimed to estimate the public health burden of HZ and the impact of vaccinating adults aged ≥ 50 years old in five Southeast Asian countries (Indonesia, Malaysia, Philippines, Thailand, and Vietnam)
-
Cost-Effectiveness of 20-Valent Pneumococcal Conjugate Vaccine Among US Children with Underlying Medical Conditions Infect. Dis. Ther. (IF 5.4) Pub Date : 2024-03-16 Mark H. Rozenbaum, Erica Chilson, Raymond Farkouh, Liping Huang, Alejandro Cane, Adriano Arguedas, Maria J. Tort, Vincenza Snow, Ahuva Averin, Derek Weycker, Dhwani Hariharan, Mark Atwood
-
K-Means Clustering Identifies Diverse Clinical Phenotypes in COVID-19 Patients: Implications for Mortality Risks and Remdesivir Impact Infect. Dis. Ther. (IF 5.4) Pub Date : 2024-03-15
Abstract Introduction The impact of remdesivir on mortality in patients with COVID-19 is still controversial. We aimed to identify clinical phenotype clusters of COVID-19 hospitalized patients with highest benefit from remdesivir use and validate these findings in an external cohort. Methods We included consecutive patients hospitalized between February 2020 and February 2021 for COVID-19. The derivation
-
Distinct Lipidomic Profiles between People Living with HIV Treated with E/C/F/TAF or B/F/TAF: An Open-Label Prospective Cohort Study Infect. Dis. Ther. (IF 5.4) Pub Date : 2024-03-15 Zhikai Wan, Junwei Su, Xueling Zhu, Xiang Liu, Yongzheng Guo, Dairong Xiang, Xiaotang Zhou, Xiaorong Peng, Ran Tao, Qing Cao, Guanjing Lang, Ying Huang, Biao Zhu
-
Serum Troponin I Assessments in 5- to 30-Year-Olds After BNT162b2 Vaccination Infect. Dis. Ther. (IF 5.4) Pub Date : 2024-03-15 Timothy E. Albertson, Caitlin Hansen, Smiti Bihari, Juleen Gayed, Xia Xu, J. Abraham Simón-Campos, Michael E. Dever, Jose F. Cardona, Essack Mitha, Jeffrey B. Baker, Georgina Keep, Islamiat Oladipupo, Federico J. Mensa, Ye Feng, Hua Ma, Kenneth Koury, Susan Mather, Claudia Ana Ianos, Annaliesa S. Anderson, Özlem Türeci, Uǧur Şahin, William C. Gruber, Alejandra Gurtman, Charu Sabharwal, Nicholas Kitchin
-
Podcast: Need for Quality Evidence for Decision-Making on Seasonal Influenza Vaccines Infect. Dis. Ther. (IF 5.4) Pub Date : 2024-03-14 Ann R. Falsey, Stefania Maggi, Tor Biering-Sørensen
Seasonal influenza is usually considered an acute respiratory infection with a full recovery within a week. In addition to the traditional outcomes, there is now evidence of indirect effects in terms of neurological and functional complications. Major organ systems can be affected, underlining the need for preventative measures against infection. The aim of this podcast, featuring Dr. Ann Falsey, Dr
-
Effect of Infusion Set Replacement Intervals on Central Line-Associated Bloodstream Infection in the Intensive Care Unit: Study Protocol of the INSPIRATION Study Infect. Dis. Ther. (IF 5.4) Pub Date : 2024-03-14 Dandan Xu, Chang Hu, Jie Xiong, Haiyan Huang, Shasha Wang, Xinbo Ding, Junying Zhou, Juan Deng, Chunling Guo, Miqi Li, Ting You, Wei Cheng, Bo Li, Xiaoqin Tang, Xiaohong Li, Hongmei Li, Jin Li, Jing Ma, Meng Xiao, Xing Fu, Huilin Li, Zhiyong Peng, Bo Hu, Fen Hu
-
Household Influenza Transmission and Healthcare Resource Utilization Among Patients Treated with Baloxavir vs Oseltamivir: A United States Outpatient Prospective Survey Infect. Dis. Ther. (IF 5.4) Pub Date : 2024-03-14 Jennie H. Best, Mitra Sadeghi, Xiaowu Sun, Arpamas Seetasith, Lisa Albensi, Seema Joshi, Marcus J. Zervos
-
Longitudinal Molecular and Serological Evidence of SARS-CoV-2 Infections and Vaccination Status: Community-Based Surveillance Study (CONTACT) Infect. Dis. Ther. (IF 5.4) Pub Date : 2024-03-10 Olga Sánchez-Soliño, Ryan D. Kilpatrick, Christopher Johnson, Yixin Fang, Yizhou Ye, Negar Niki Alami, Katarzyna Zarish, Whitney S. Krueger, Nancy Dreyer, Gregory C. Gray
-
Epidemiology of Reportable Bacterial Infectious Diseases in Saudi Arabia Infect. Dis. Ther. (IF 5.4) Pub Date : 2024-03-10 Nada K. Alhumaid, Areej M. Alajmi, Nada F. Alosaimi, Maryam Alotaibi, Thamer A. Almangour, Majed S. Nassar, Ziad A. Memish, Abdulwahab Z. Binjomah, Ahmed Al-Jedai, Abdulaziz S. Almutairi, Saeed Algarni, Noura M. Alshiban, Munirah S. Aleyiydi, Abdulkader F. Tawfik, Atef Shibl, Essam A. Tawfik
Introduction Bacterial infections have a significant impact on human health; they can cause severe morbidity and mortality, particularly in susceptible populations. Epidemiological surveillance is a critical tool for monitoring the population's health and facilitate the prevention and control of infectious disease outbreaks. Knowing the burden of bacterial communicable diseases is an initial core step
-
Clinical Characteristics of Uncomplicated Acute Pyelonephritis Caused by Escherichia coli and Klebsiella pneumoniae Infect. Dis. Ther. (IF 5.4) Pub Date : 2024-03-09 Miri Hyun, Ji Yeon Lee, Kyong Ree Lim, Hyun ah Kim
-
Effect of Renal Impairment on Pharmacokinetics and Safety of Ensitrelvir, a SARS-CoV-2 3CL Protease Inhibitor Infect. Dis. Ther. (IF 5.4) Pub Date : 2024-03-09 Takayuki Katsube, Safwan Kezbor, Ryosuke Shimizu, Ryuji Kubota
-
Amoebic Liver Abscess: Potential Application of New Diagnostic Techniques for an Old Pathogen Infect. Dis. Ther. (IF 5.4) Pub Date : 2024-03-08 Federica Portunato, Claudia Bartalucci, Antonio Vena, Daniele Roberto Giacobbe, Elisa Porcile, Paolo Montanelli, Nataniele Piol, Monica Centanaro, Enzo Andorno, Matteo Bassetti
-
Living During COVID-19 While Immunocompromised: A Patient and Physician Perspective from France Infect. Dis. Ther. (IF 5.4) Pub Date : 2024-03-08 Elise Foudrat, Sophie Caillard
This article is co-authored by a kidney transplant recipient and her nephrologist. By sharing her personal experience of the coronavirus disease 2019 (COVID-19) pandemic, the patient illustrates the concerns of immunocompromised patients during this unprecedented health crisis. She describes the difficulties encountered at work, the omnipresent protective measures, and the need for appropriate information
-
The Impact of the COVID-19 Pandemic on the Incidence of Herpes Zoster: A Narrative Literature Review Infect. Dis. Ther. (IF 5.4) Pub Date : 2024-03-05
Abstract Coronavirus disease 2019 (COVID-19) has had a broad impact on health services and health outcomes. During the pandemic, there were numerous reports of herpes zoster (HZ) in people with COVID-19 and in COVID-19 vaccine recipients. The aim of this review is to elucidate the global effects of the COVID-19 pandemic on HZ. It is postulated that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
-
4CMenB Vaccination to Prevent Meningococcal B Disease in Vietnam: Expert Review and Opinion Infect. Dis. Ther. (IF 5.4) Pub Date : 2024-03-02
Abstract An advisory board meeting was held with experts in Vietnam (Hanoi, August 2022), to review the evidence on invasive meningococcal disease (IMD) epidemiology, clinical management, and meningococcal vaccines to reach a consensus on recommendations for meningococcal vaccination in Vietnam. IMD is a severe disease, with the highest burden in infants and children. IMD presents as meningitis and/or
-
Dalbavancin Sequential Therapy for Gram-Positive Bloodstream Infection: A Multicenter Observational Study Infect. Dis. Ther. (IF 5.4) Pub Date : 2024-03-01 Nicholas Rebold, Sara Alosaimy, Jeffrey C. Pearson, Brandon Dionne, Ahmad Taqi, Abdalhamid Lagnf, Kristen Lucas, Mark Biagi, Nicholas Lombardo, Joshua Eudy, Daniel T. Anderson, Monica V. Mahoney, Wesley D. Kufel, Joseph A. D’Antonio, Bruce M. Jones, Jeremy J. Frens, Tyler Baumeister, Matthew Geriak, George Sakoulas, Dimitrios Farmakiotis, Dino Delaportas, Jeremy Larew, Michael P. Veve, Michael J. Rybak
-
Direct-Acting Antivirals Remain Cost-Effective Treatments for Chronic Hepatitis C in Australia Despite Changes to the Treated Population and the Availability of Retreatment: The Glecaprevir/Pibrentasvir (Maviret®) Example Infect. Dis. Ther. (IF 5.4) Pub Date : 2024-03-01 Emma Warren, Belinda J. C. Castles, Gillian C. Sharratt, Aitor Arteaga
-
Oritavancin Versus Daptomycin for Osteomyelitis Treatment After Surgical Debridement Infect. Dis. Ther. (IF 5.4) Pub Date : 2024-02-29 Nicholas W. Van Hise, Russell M. Petrak, Kairav Shah, Melina Diaz, Vishnu Chundi, Mark Redell
Introduction Weekly intravenous (IV) oritavancin and daily daptomycin were compared in an outpatient setting following extensive surgical debridement for treating patients with osteomyelitis. Methods This was a retrospective, observational study of patients diagnosed with acute osteomyelitis. Exclusion criteria were the use of Gram-negative antibiotic therapy, use of antibiotics for more than 48 h
-
Safety, Efficacy and Pharmacokinetics of AZD7442 (Tixagevimab/Cilgavimab) for Treatment of Mild-to-Moderate COVID-19: 15-Month Final Analysis of the TACKLE Trial Infect. Dis. Ther. (IF 5.4) Pub Date : 2024-02-25 F. D. Richard Hobbs, Hugh Montgomery, Francisco Padilla, Jesus Abraham Simón-Campos, Douglas Arbetter, Seth Seegobin, Alexandre Kiazand, Katie Streicher, Nuria Martinez-Alier, Taylor S. Cohen, Mark T. Esser
-
A Population-Based Study on the Incidence, Risk Factors, and Outcome of Salmonella Bloodstream Infections in South Sweden 2012–2022 Infect. Dis. Ther. (IF 5.4) Pub Date : 2024-02-23 L. Björklund, Y. Mattisson, A. Bläckberg, T. Sunnerhagen, O. Ljungquist
-
Surgical Treatment of Persistent Pseudomonas aeruginosa Bacteraemia After n-Butyl-2-cyanoacrylate for Gastric Bleeding Varices Infect. Dis. Ther. (IF 5.4) Pub Date : 2024-02-23 Abiu Sempere, Gabriela Chullo, Sabina Herrera, Jorge Boán, Elisa Pose, María Londoño, Virginia Hernandez-Gea, Miguel Ángel Verdejo, Juan Carlos García-Valdecasas, Cristina Pitart, Yiliam Fundora, Alex Soriano, Marta Bodro
-
Outcomes of Drug Interactions Between Antiretrovirals and Co-Medications, Including Over-the-Counter Drugs: A Real-World Study Infect. Dis. Ther. (IF 5.4) Pub Date : 2024-02-19 Juan Ambrosioni, Natalia Anahí Díaz, Catia Marzolini, Gordana Dragovic, Arkaitz Imaz, Andrea Calcagno, Sonia Luque, Adrian Curran, Jesus Troya, Montse Tuset, Saye Khoo, David Burger, Claudia P. Cortés, Nadia Naous, Jose Molto
-
Cost of Illness Analysis of Invasive Meningococcal Disease Caused by Neisseria Meningitidis Serogroup B in the Netherlands—a Holistic Approach Infect. Dis. Ther. (IF 5.4) Pub Date : 2024-02-16 Florian Zeevat, Joost J. M. Simons, Tjalke A. Westra, Jan C. Wilschut, Nina M. van Sorge, Cornelis Boersma, Maarten J. Postma
-
A Systematic Literature Review on Risk Factors for and Timing of Clostridioides difficile Infection in the United States Infect. Dis. Ther. (IF 5.4) Pub Date : 2024-02-13
Abstract Introduction Clostridioides difficile infection (CDI) is a major public health threat. Up to 40% of patients with CDI experience recurrent CDI (rCDI), which is associated with increased morbidity. This study aimed to define an at-risk population by obtaining a detailed understanding of the different factors leading to CDI, rCDI, and CDI-related morbidity and of time to CDI. Methods We conducted
-
Estimated Respiratory Syncytial Virus-Related Hospitalizations and Deaths Among Children and Adults in Spain, 2016–2019 Infect. Dis. Ther. (IF 5.4) Pub Date : 2024-02-06 Mariana Haeberer, Robin Bruyndonckx, Aleksandra Polkowska-Kramek, Antoni Torres, Caihua Liang, Charles Nuttens, Maribel Casas, Francesca Lemme, Worku Biyadgie Ewnetu, Thao Mai Phuong Tran, Jessica E. Atwell, Cristina Mendez Diez, Bradford D. Gessner, Elizabeth Begier
-
Epidemiology of Pertussis and Pertussis-Related Complications in Adults: A German Claims Data Analysis Infect. Dis. Ther. (IF 5.4) Pub Date : 2024-01-31 Bastian Surmann, Julian Witte, Manuel Batram, Carl Peter Criée, Christiane Hermann, Andreas Leischker, Jörg Schelling, Mirko Steinmüller, Klaus Wahle, Alexander F. Heiseke, Pavo Marijic
-
First-in-Human Safety, Tolerability, and Pharmacokinetics of Single-Dose Kukoamine B Mesylate in Healthy Subjects: A Randomized, Double-Blind, Placebo-Controlled Phase I Study Infect. Dis. Ther. (IF 5.4) Pub Date : 2024-01-30
Abstract Introduction Kukoamine B mesylate (KB) is a mesylate chrysamine B targeting lipopolysaccharides and CpG DNA, two potential treatment targets in sepsis. Methods This first-in-human, randomized, double-blind, placebo-controlled, phase I study was conducted from July 2014 to May 2015 to explore the safety, tolerability, and pharmacokinetics of KB in healthy subjects. This study consisted of a
-
Association Between Risk of Clostridium difficile Infection and Duration of Proton Pump Inhibitor or H2-Receptor Antagonist Use in Hospitalized Patients Infect. Dis. Ther. (IF 5.4) Pub Date : 2024-01-30
Abstract Introduction Limited studies have evaluated the association between Clostridium difficile infection (CDI) and the duration of proton pump inhibitor (PPI) or histamine H2-receptor blocker (H2RA) use and provided a cutoff duration for PPI or H2RA use to mitigate a substantially increased risk of CDI. We aimed to evaluate these associations in hospitalized patients using a nationwide insurance
-
Effect of Bamlanivimab as Monotherapy or in Combination with Etesevimab or Sotrovimab on Persistently High Viral Load in Patients with Mild-to-Moderate COVID-19: A Randomized, Phase 2 BLAZE-4 Trial Infect. Dis. Ther. (IF 5.4) Pub Date : 2024-01-30 Russell M. Nichols, Lisa Macpherson, Dipak R. Patel, Wendy W. Yeh, Amanda Peppercorn
-
The Diverse Spectrum of Invasive Meningococcal Disease in Pediatric and Adolescent Patients: Narrative Review of Cases and Case Series Infect. Dis. Ther. (IF 5.4) Pub Date : 2024-01-29 Shravani Bobde, Woo-Yun Sohn, Rafik Bekkat-Berkani, Angelika Banzhoff, Athena Cavounidis, Ener Cagri Dinleyici, Wilfrido Coronell Rodriguez, Nelly Ninis
-
Letermovir Effectively Prevents Cytomegalovirus Infection in Patients with Aplastic Anemia After Hematopoietic Stem Cell Transplantation: A Real-World Retrospective Cohort Study Infect. Dis. Ther. (IF 5.4) Pub Date : 2024-01-24 Yuling Zhang, Xiaowei Chen, Ming Zhou, Yuping Zhang, Cunte Chen, Ruiqing Zhou, Yumiao Li, Fangfang Yang, Shilin Xu, Caixia Wang, Wei Zhou, Tingfen Deng, Shiyi Pan, Wenjian Mo, Shunqing Wang
-
Clinical Characteristics of Lung Consolidation with Mycoplasma pneumoniae Pneumonia and Risk Factors for Mycoplasma pneumoniae Necrotizing Pneumonia in Children Infect. Dis. Ther. (IF 5.4) Pub Date : 2024-01-24
Abstract Introduction Mycoplasma pneumoniae necrotizing pneumonia (MPNP) is an uncommon but increasingly recognized severe complication of pneumonia, and the delayed diagnosis and treatment are prone to pulmonary sequelae. The aim of this study is to explore independent risk factors for MPNP in children with lung consolidation. Methods A retrospective observational study was conducted on 118 children
-
Impact of Invasive Escherichia Coli Disease on Clinical Outcomes and Medical Resource Utilization Among Asian Patients in the United States Infect. Dis. Ther. (IF 5.4) Pub Date : 2024-01-24 Chao Zhuo, Bo Zheng, Kittima Wattanakamolkul, Yoshikazu Nakayama, Martin Cloutier, Marjolaine Gauthier-Loiselle, Jun Feng, David Wu, Maureen P. Neary, Jeroen Geurtsen, Antoine C. El Khoury, Yoshiaki Gu
-
Comparative Analysis of Outpatient Antibiotic Prescribing in Early Life: A Population-Based Study Across Birth Cohorts in Denmark and Germany Infect. Dis. Ther. (IF 5.4) Pub Date : 2024-01-23 Oliver Scholle, Lotte Rasmussen, Mette Reilev, Jost Viebrock, Ulrike Haug
-
Navigating the Complex Landscape of Ebola Infection Treatment: A Review of Emerging Pharmacological Approaches Infect. Dis. Ther. (IF 5.4) Pub Date : 2024-01-19
Abstract In 1976 Ebola revealed itself to the world, marking the beginning of a series of localized outbreaks. However, it was the Ebola outbreak that began in 2013 that incited fear and anxiety around the globe. Since then, our comprehension of the virus has been steadily expanding. Ebola virus (EBOV), belonging to the Orthoebolavirus genus of the Filoviridae family, possesses a non-segmented, negative
-
Rates of Lower Respiratory Tract Illness in US Adults by Age and Comorbidity Profile Infect. Dis. Ther. (IF 5.4) Pub Date : 2024-01-18 Derek Weycker, Ahuva Averin, Linnea Houde, Kevin Ottino, Kimberly Shea, Reiko Sato, Bradford D. Gessner, Kari Yacisin, Daniel Curcio, Elizabeth Begier, Mark Rozenbaum
-
Efficacy and Health-Related Quality of Life Impact of Fecal Microbiota, Live-jslm: A Post Hoc Analysis of PUNCH CD3 Patients at First Recurrence of Clostridioides difficile Infection Infect. Dis. Ther. (IF 5.4) Pub Date : 2024-01-18 Paul Feuerstadt, Jessica R. Allegretti, Erik R. Dubberke, Amy Guo, Adam Harvey, Min Yang, Viviana Garcia-Horton, Mirko Fillbrunn, Glenn Tillotson, Lindy L. Bancke, Kerry LaPlante, Kevin W. Garey, Sahil Khanna
-
Safety and Effectiveness of Molnupiravir in Japanese Patients with COVID-19: Final Report of Post-marketing Surveillance in Japan Infect. Dis. Ther. (IF 5.4) Pub Date : 2024-01-17
Abstract Introduction Molnupiravir is an orally available prodrug of N-hydroxycytidine that received special approval for emergency treatment of coronavirus disease 2019 (COVID-19) in Japan in December 2021 and full approval in April 2023. To assess the real-world safety and effectiveness of molnupiravir in Japanese patients with COVID-19, we conducted nationwide post-marketing surveillance to collect
-
A First-in-Human Randomized Study to Assess the Safety, Tolerability, Pharmacokinetics, and Neutralization Profile of Two Investigational Long-Acting Anti-SARS-CoV-2 Monoclonal Antibodies Infect. Dis. Ther. (IF 5.4) Pub Date : 2024-01-14 Norman Moullan, Josephat Asiago, Kathryn Stecco, Salah Hadi, Moetaz Albizem, Holly Tieu, Björn Hock, Craig Fenwick, Kai Lin, Thomas Lengsfeld, Lauren Poffenbarger, David Liu, Didier Trono, Giuseppe Pantaleo, Rajeev Venkayya, Prakash Bhuyan
-
Nirmatrelvir/Ritonavir Utilization for the Treatment of Non-hospitalized Adults with COVID-19 in the National Veterans Affairs (VA) Healthcare System Infect. Dis. Ther. (IF 5.4) Pub Date : 2024-01-13 Haley J. Appaneal, Kerry L. LaPlante, Vrishali V. Lopes, Catherine Martin, Laura Puzniak, Timothy L. Wiemken, Evan J. Zasowski, John M. McLaughlin, Aisling R. Caffrey
-
Clinical Efficacy and Safety of Colistin Sulfate in the Treatment of Carbapenem-Resistant Organism Infections in Patients with Hematological Diseases Infect. Dis. Ther. (IF 5.4) Pub Date : 2024-01-11 Yuanbing Wu, Shanshan Jiang, Dongyang Li, Yaxue Wu, Qian Li, Xing Wang, Bin Liu, Haiyan Bao, Depei Wu, Xiaohui Hu
-
Incidence and Burden of Herpes Zoster in Sweden: A Regional Population-Based Register Study Infect. Dis. Ther. (IF 5.4) Pub Date : 2024-01-09 Emma Södergren, Kristina Mårdberg, Marie Nishimwe, Amit Bhavsar, Alen Marijam, Tomas Bergström, Patrik Stäck
-
Remdesivir for the Treatment of COVID-19: A Narrative Review Infect. Dis. Ther. (IF 5.4) Pub Date : 2024-01-09
Abstract Despite the wide availability of effective vaccines, COVID-19 continues to be an infectious disease of global importance. Remdesivir is a broad-spectrum antiviral and was the first US Food and Drug Administration-approved treatment for COVID-19. In clinical guidelines, remdesivir is currently the only recommended antiviral for use in hospitalized patients with COVID-19, with or without a supplemental
-
Global Prevalence of Varicella-Associated Complications: A Systematic Review and Meta-Analysis Infect. Dis. Ther. (IF 5.4) Pub Date : 2023-12-19
Abstract Introduction Varicella (chickenpox) is an infectious disease caused by the varicella zoster virus affecting children, adolescents, and adults. Varicella symptoms are usually self-limiting; however, different complications with widespread and systemic manifestations can occur. This systematic literature review aims to explore and quantify varicella-associated complication rates. Methods Two
-
Developing a Tool for Differentiation Between Bacterial and Viral Respiratory Infections Using Myxovirus Resistance Protein A and C-Reactive Protein Infect. Dis. Ther. (IF 5.4) Pub Date : 2023-12-19 Konstantina Iliopoulou, Panagiotis Koufargyris, Sarantia Doulou, Elisavet Tasouli, Sokratis Katopodis, Stavroula-Porphyria Chachali, Georgios Schinas, Charalampos Karachalios, Myrto Astriti, Paraskevi Katsaounou, George Chrysos, Theodoros Seferlis, Effrosyni Dimopoulou, Myrto Kollia, Garyphalia Poulakou, Styliani Gerakari, Ilias C. Papanikolaou, Haralampos Milionis, George N. Dalekos, Vasiliki Tzavara
-
Safety and Immunogenicity of a Recombinant Two-Component SARS-CoV-2 Protein Vaccine: Randomized, Double-Blind, Placebo-Controlled Phase I and Phase II Studies Infect. Dis. Ther. (IF 5.4) Pub Date : 2023-12-16 Chris Wynne, Abundio Balgos, Jingxin Li, Paul Hamilton, Louie Tirador, Anjuli May Jaen, Chen Mo, Zijing Yue, Ying Ma, Qingshuang Wang, Rendu Wen, Zheng Yao, Jiaping Yu, Wenrong Yao, Jianhui Zhang, Hui Zheng, Kunxue Hong, Fengcai Zhu, Yong Liu
-
A Randomized, Open-Label, Non-inferiority Clinical Trial Assessing 7 Versus 14 Days of Antimicrobial Therapy for Severe Multidrug-Resistant Gram-Negative Bacterial Infections: The OPTIMISE Trial Protocol Infect. Dis. Ther. (IF 5.4) Pub Date : 2023-12-16
Abstract Introduction Shorter courses of antimicrobials have been shown to be non-inferior to longer, “traditional” duration of therapies, including for some severe healthcare-associated infections, with a few exceptions. However, evidence is lacking regarding shorter regimes against severe infections by multidrug-resistant Gram-negative bacteria (MDR-GNB), which are often caused by distinct strains
-
Correction: Epidemiological Changes and Improvement in Outcomes of Infective Endocarditis in Europe in the Twenty-First Century: An International Collaboration on Endocarditis (ICE) Prospective Cohort Study (2000–2012) Infect. Dis. Ther. (IF 5.4) Pub Date : 2023-12-15 Juan Ambrosioni, Marta Hernández-Meneses, Emanuele Durante-Mangoni, Pierre Tattevin, Lars Olaison, Tomas Freiberger, John Hurley, Margaret M. Hannan, Vivian Chu, Bruno Hoen, Asunción Moreno, Guillermo Cuervo, Jaume Llopis, José M. Miró
-
Assessing the Underestimation of Adult Pertussis Disease in Five Latin American Countries Infect. Dis. Ther. (IF 5.4) Pub Date : 2023-12-14 Adriana Guzman-Holst, Jorge A. Gomez, Otavio Cintra, Desirée Van Oorschot, Nicolas Jamet, Javier Nieto-Guevara
-
Burden of Herpes Zoster in Individuals with Immunocompromised Conditions and Autoimmune Diseases in the Republic of Korea: A Nationwide Population-Based Database Study Infect. Dis. Ther. (IF 5.4) Pub Date : 2023-12-12 Jing Chen, Ju-Young Shin, Sumitra Shantakumar, Sungho Bea, Byong Duk Ye, Dong-Gun Lee, Hyungwoo Kim, Won Suk Choi, Iain Kaan
-
Meningococcal Disease in the Post–COVID-19 Era: A Time to Prepare Infect. Dis. Ther. (IF 5.4) Pub Date : 2023-12-04 David E. Bloom, Paolo Bonanni, Federico Martinón-Torres, Peter C. Richmond, Marco A. P. Safadi, David M. Salisbury, Apostolos Charos, Katharina Schley, Jamie Findlow, Paul Balmer
-
Safety and Immunogenicity of Homologous Recombinant Adenovirus Type 5-Vectored COVID-19 Vaccine Booster Dose in Healthy Adults Aged 18–60 Years: a Single-Center, Open-Label Trial Infect. Dis. Ther. (IF 5.4) Pub Date : 2023-12-01 Siyue Jia, Jinlong Zhang, Xue Wang, Zhe Zhang, Busen Wang, Jun Zhang, Hudachuan Jiang, Ge Guo, Ying Wang, Jingxuan Wan, Wenjuan Wang, Lihua Hou, Fengcai Zhu
-
Factors Associated with Geographical Variability of Antimicrobial Use in Japan Infect. Dis. Ther. (IF 5.4) Pub Date : 2023-11-29 Taito Kitano, Shinya Tsuzuki, Ryuji Koizumi, Kensuke Aoyagi, Yusuke Asai, Yoshiki Kusama, Norio Ohmagari
-
Virologic Outcomes with Molnupiravir in Non-hospitalized Adult Patients with COVID-19 from the Randomized, Placebo-Controlled MOVe-OUT Trial Infect. Dis. Ther. (IF 5.4) Pub Date : 2023-11-23 Julie M. Strizki, Jay A. Grobler, Nicholas Murgolo, Arthur Fridman, Matthew G. Johnson, Jiejun Du, Patricia Carmelitano, Michelle L. Brown, Amanda Paschke, Carisa De Anda
-
Podcast: Influenza-Associated Complications and the Impact of Vaccination on Public Health Infect. Dis. Ther. (IF 5.4) Pub Date : 2023-11-23 Stefania Maggi, Melissa K. Andrew, Annemarijn de Boer
Influenza is primarily considered an acute respiratory infection but can lead to a myriad of medium and long-term sequelae across every major organ system in the body. Increasing awareness, gaining broader understanding of its mechanistic pathways, identifying at-risk individuals, and determining how to better protect them could help minimize its impact. The aim of this podcast, featuring Dr Stefania