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Factors influencing rapid antiretroviral therapy initiation in Jiulongpo, Chongqing, China: a retrospective cohort from 2018 to 2022 Aids Res. Ther. (IF 2.2) Pub Date : 2024-03-17 Cheng Chen, Hao Chen, Lingli Wu, Qin Gong, Jingchun He
Antiretroviral Therapy (ART) is pivotal in extending the lives of people living with HIV (PLWH) and minimizing transmission. Rapid ART initiation, defined as commencing ART within seven days of HIV diagnosis, is recommended for all PLWH. A retrospective cohort study was conducted using data from the China Information System for Disease Control and Prevention. This study included PLWH diagnosed between
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Support, not blame: safe partner disclosure among women diagnosed with HIV late in pregnancy in South Africa and Uganda Aids Res. Ther. (IF 2.2) Pub Date : 2024-03-13 Adelline Twimukye, Yussif Alhassan, Beate Ringwald, Thokozile Malaba, Landon Myer, Catriona Waitt, Mohammed Lamorde, Helen Reynolds, Saye Khoo, Miriam Taegtmeyer
HIV partner disclosure rates remain low among pregnant women living with HIV in many African countries despite potential benefits for women and their families. Partner disclosure can trigger negative responses like blame, violence, and separation. Women diagnosed with HIV late in pregnancy have limited time to prepare for partner disclosure. We sought to understand challenges around partner disclosure
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Diffuse myocardial fibrosis is uncommon in people with perinatally acquired human immunodeficiency virus infection Aids Res. Ther. (IF 2.2) Pub Date : 2024-03-04 Jason L. Williams, Frances Hung, Elizabeth Jenista, Piers Barker, Hrishikesh Chakraborty, Raymond Kim, Andrew W. McCrary, Svati H. Shah, Nathan Thielman, Gerald S. Bloomfield
Cardiovascular disease (CVD) remains a leading cause of death in people living with HIV. Myocardial fibrosis is well-described in HIV infection acquired in adulthood. We evaluate the burden of fibrosis by cardiac magnetic resonance in people with perinatal HIV infection. Individuals with perinatally acquired HIV (pnHIV) diagnosed before 10 years-old and on antiretroviral treatment for ≥ 6 months were
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Brief communication: body composition and hidden obesity in people living with HIV on antiretroviral therapy Aids Res. Ther. (IF 2.2) Pub Date : 2024-03-01 K. Konishi, H. Nakagawa, T. Asaoka, Y. Kasamatsu, T. Goto, M. Shirano
Increased incidence of lifestyle diseases as side-effects of antiretroviral therapy (ART) have been reported in people living with HIV (PLWH). Few studies have evaluated obesity and hidden obesity in Japanese PLWH and their association with ART. In order to provide more appropriate drug selection and lifestyle guidance, we investigated the relationship between the effects of HIV infection and ART on
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Factors associated with knowledge of mother-to-child transmission of HIV among reproductive-age women in Indonesia: a multilevel analysis Aids Res. Ther. (IF 2.2) Pub Date : 2024-02-20 Agani Afaya, Aloysia Ispriantari
Maternal transmission of human immunodeficiency virus (HIV) commonly occurs from mother to child during pregnancy, delivery, and breastfeeding which accounts for almost all the new HIV infections among children aged 0–14 years. Despite major efforts and progress in controlling and preventing HIV, it continues to pose a great public health threat, especially in Indonesia. This study assessed the factors
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Characterization of intestinal fungal community diversity in people living with HIV/AIDS (PLWHA) Aids Res. Ther. (IF 2.2) Pub Date : 2024-02-13 Pengfei Meng, Guichun Zhang, Xiuxia Ma, Xue Ding, Xiyuan Song, Shuyuan Dang, Ruihan Yang, Liran Xu
Acquired Immune Deficiency Syndrome (AIDS) is a highly dangerous infectious disease caused by the Human Immunodeficiency Virus (HIV), a virus that attacks the human immune system. To explore the correlation between intestinal fungal community and immune function (Immune cells and inflammatory factors) in people living with HIV/AIDS (PLWHA). The feces and blood samples were collected from two groups
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A call for change: addressing the implementation strategy using pre exposure Prophylaxis for combating the escalating HIV crisis in Zanzibar’s key populations Aids Res. Ther. (IF 2.2) Pub Date : 2024-02-09 Mansour Maulid Mshenga, Weiming Tang
The Integrated Bio-Behavioural Surveillance Survey of 2022–2023 among key populations report from Zanzibar has been released. The prevalence of HIV is estimated to be 21.1%, 11.4%, and 9.3% among Female Sex Workers, Men who have Sex with Men, and People Who Injected Drugs, respectively. This has prompted a closer examination of the factors contributing to this trend, with a particular focus on the
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Outcomes of antiretroviral treatment for 0-14-year-old children living with HIV in Ganzhou, China, 2006–2023 Aids Res. Ther. (IF 2.2) Pub Date : 2024-01-31 Ting Zeng, Xin Chen, Xiao-Yi Zhang, Chao-Xian Lian, Rong-Rong Yang, Li-Ling Yu, Xiao-Kang Liao, Dan-Dan Huang, Yu-Ning Zhang, Hong-Min Cao
Studies on antiretroviral therapy (ART) in children living with HIV (CLHIV) are limited due to the small population and low accession rate of ART. All 0-14-year-old CLHIV admitted to the Ganzhou Center for Disease Control and Prevention from January 2006 to June 2023 were included retrospectively. The information of treatment regimens, disease progression, and laboratory tests of the patients under
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Experiences of people living with HIV in low- and middle-income countries and their perspectives in self-management: a meta-synthesis Aids Res. Ther. (IF 2.2) Pub Date : 2024-01-31 Tegene Legese Dadi, Anja M. C. Wiemers, Yadessa Tegene, Girmay Medhin, Mark Spigt
Availability of anti-retroviral treatment has changed HIV in to a manageable chronic disease, making effective self-management essential. However, only a few studies in low- and middle-income countries (LMICs) reported experiences of people living with HIV (PLWH) on self-management. This meta-synthesis of qualitative studies investigated perspectives of PLWH in LMICs on self-management. Various databases
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Satisfaction of antiretroviral therapy services and its associated factors among adult clients attending antiretroviral therapy in Woliso town, Ethiopia Aids Res. Ther. (IF 2.2) Pub Date : 2024-01-22 Bayisa Abdissa, Rahel Abdissa, Jiregna Derega, Senahara Korsa Wake
Antiretroviral therapy client satisfaction is a significant tool that enables to strengthen the quality of life of the clients. The study aimed to assess the satisfaction of clients with antiretroviral therapy services and its associated factors among adult clients attending antiretroviral therapy. A cross-sectional study was undertaken from 28 August to 27 October 2022. Data were analyzed by using
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Hypertension among persons living with HIV/AIDS and its association with HIV-related health factors Aids Res. Ther. (IF 2.2) Pub Date : 2024-01-11 Mawulorm K. I. Denu, Ritika Revoori, Maame Araba E. Buadu, Oluwakemi Oladele, Kofi Poku Berko
Human Immunodeficiency Virus (HIV) infection remains a public health concern in many countries. The increased life expectancy in the post-Antiretroviral Therapy (ART) era has led to an increased risk of cardiovascular disease and death among Persons Living with HIV (PLHIV). Hypertension remains a significant risk factor for cardiovascular disease among PLHIV. Some studies have suggested associations
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Effect of dolutegravir-based versus efavirenz-based antiretroviral therapy on excessive weight gain in adult treatment-naïve HIV patients at Matsanjeni health center, Eswatini: a retrospective cohort study Aids Res. Ther. (IF 2.2) Pub Date : 2024-01-07 Didier M. Mukuna, Tom Decroo, Clara M. Nyapokoto
There is limited data on dolutegravir (DTG)-associated weight gain from settings with a dual burden of HIV and overnutrition. In Eswatini (at Matsanjeni), among 156 and 160 adult patients on DTG-based and EFV-based antiretroviral therapy (ART), respectively, we studied excessive weight gain (BMI at 24 months ART greater than baseline and ≥25 kg/m2). The median BMI increase in DTG-based patients was
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Bifocal malakoplakia in a patient living with HIV: case report Aids Res. Ther. (IF 2.2) Pub Date : 2024-01-07 Mohammed Alsaeed, Mohamed Mursi, Nazik Eltayeb, Hadi Kuriry, Salafa Albaghli, Yasir Alrusayni
Malakoplakia is a rare chronic granulomatous disease characterized by the presence of Michaelis-Gutmann bodies (MGBs) within histiocytic aggregates. It predominantly affects immunocompromised individuals, including those living with Human Immunodeficiency Virus (HIV). We present a unique case of bifocal malakoplakia in a 49-year-old man, previously with Coronavirus disease 2019 (COVID-19) and HIV positive
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Empyema caused by Streptococcus constellatus in a patient infected with HIV: a case report and literature review Aids Res. Ther. (IF 2.2) Pub Date : 2024-01-03 Hong-Hong Yang, Mei Li, Qing Yu, Qian Liu, Min Liu
Empyema caused by Streptococcus constellatus (S. constellatus) is rare in patients with HIV. To analyze the clinical data of a patient living with HIV (PLHIV), who got empyema caused by S. constellatus, investigating the diagnosis and treatment of this disease through literature review to improve the clinical understanding of this disease. We have reported here a 58-year-old male PLHIV with cough,
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Brief communications: changes in inflammatory biomarkers and lipid profiles after switching to long-acting cabotegravir plus rilpivirine Aids Res. Ther. (IF 2.2) Pub Date : 2024-01-03 Eisuke Adachi, Makoto Saito, Amato Otani, Michiko Koga, Hiroshi Yotsuyanagi
We assessed whether the impact of cabotegravir plus rilpivirine on inflammation reduction differs from that of oral antiretrovirals, using real-world data. Inflammatory biomarkers and lipid profiles were followed from baseline to 8 months after switching. Seventy-eight participants were analyzed. The CD4/CD8 ratio and C-reactive protein did not change. There were transient decreases in CD8 and CD4
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Adolescent’s and youth’s adherence to antiretroviral therapy for better treatment outcome and its determinants: multi-center study in public health facilities Aids Res. Ther. (IF 2.2) Pub Date : 2023-12-19 Yihenew Zurbachew, Desta Hiko, Girma Bacha, Hailu Merga
Low-adherence to Anti-retroviral therapy (ART) negatively affects the clinical, immunological, and virologic outcomes of patients. Adherence is the most important factor in determining Antiretroviral Therapy (ART) treatment success and long-term viral suppression which ultimately reduces morbidity and mortality. Thus, this study aimed to identify factors affecting adherence to antiretroviral therapy
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Risk factors for unsuppressed viral load after intensive adherence counseling among HIV infected persons in Kampala, Uganda: a nested case–control study Aids Res. Ther. (IF 2.2) Pub Date : 2023-12-19 Jonathan Izudi, Barbara Castelnuovo, Rachel King, Adithya Cattamanchi
Intensive adherence counseling (IAC) is the global standard of care for people living with human immunodeficiency virus (PLHIV) who have unsuppressed VL after ≥ 6 months of first-line anti-retroviral therapy (ART). We investigated whether the number of IAC sessions is associated with suppressed VL among PLHIV in Kampala, Uganda. We conducted a nested case-control study among PLHIV with unsuppressed
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Prevalence of depression among people living with HIV in rural hospitals in South-Western Nigeria-Association with clinico-demographic factors Aids Res. Ther. (IF 2.2) Pub Date : 2023-12-16 Waheed Adeola Adedeji, Qing Ma, Abiodun Muhammed Raji, Raymond Cha, Olaniran Mudasiru Rasaki, Alan Hutson, Babafemi O. Taiwo, Man E. Charurat, Oyindamola B. Yusuf, Fatai Adewale Fehintola, Oye Gureje, Gene D. Morse
Major depression is the most common neuropsychiatric disorder among people living with HIV (PLWH) and is predictive of high morbidity and mortality among them. This study estimated the prevalence and explored factors associated with depression among PLWH in two rural secondary health facilities providing anti-retroviral therapy (ART) services in Southwestern Nigeria between September and December 2020
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Determinants of survival of adolescents receiving antiretroviral therapy in the Centre Region of Cameroon: a multi-centered cohort-analysis Aids Res. Ther. (IF 2.2) Pub Date : 2023-12-15 Nicholas Tendongfor, Joseph Fokam, Collins Ambe Chenwi, Fabrice Léo Tamhouo Nwabo, Armanda Nangmo, Njume Debimeh, Suzie Tetang Ndiang Moyo, Marie Patrice Halle, Anne-Esther Njom-Nlend, Paul Koki Ndombo, Alexis Ndjolo
In spite of the global decreasing mortality associated with HIV, adolescents living with HIV (ADLHIV) in sub-Saharan Africa still experience about 50% mortality rate. We sought to evaluate survival rates and determinants of mortality amongst ADLHIV receiving antiretroviral therapy (ART) in urban and rural settings. A multi-centered, 10-year retrospective, cohort-study including ADLHIV on ART ≥ 6 months
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Addressing HIV stigma in healthcare, community, and legislative settings in Central and Eastern Europe Aids Res. Ther. (IF 2.2) Pub Date : 2023-12-11 Ana-Maria Schweitzer, Arian Dišković, Veronica Krongauz, Julie Newman, Janez Tomažič, Nina Yancheva
Surging HIV prevalence across countries of Central and Eastern Europe (CEE) is largely a result of poor HIV care engagement and a lack of comprehensive support for key populations. This is fostered by widespread stigma across healthcare, community, and legislative settings. Throughout CEE, HIV stigma and intersectional stigma are serious obstacles to providing adequate medical care to people living
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Research priorities in HIV, aging and rehabilitation: building on a framework with the Canada-International HIV and Rehabilitation Research Collaborative Aids Res. Ther. (IF 2.2) Pub Date : 2023-12-09 Kelly K. O’Brien, Francisco Ibáñez-Carrasco, Kelly Birtwell, Graeme Donald, Darren A. Brown, Andrew D. Eaton, Bakita Kasadha, Emma Stanmore, Natalie St. Clair-Sullivan, Liam Townsend, Jaime H. Vera, Patricia Solomon
In 2016, the Canada-International HIV and Rehabilitation Research Collaborative established a framework of research priorities in HIV, aging and rehabilitation. Our aim was to review and identify any new emerging priorities from the perspectives of people living with HIV, clinicians, researchers, and representatives from community organizations. We conducted a multi-stakeholder international consultation
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Clinical, molecular, and histological characteristics of severely necrotic and fatal mpox in HIV-infected patients Aids Res. Ther. (IF 2.2) Pub Date : 2023-11-27 Sandra Rajme-López, Ever A. Corral-Herrera, Andrea C. Tello-Mercado, Karen M. Tepo-Ponce, Raúl E. Pérez-Meléndez, Ángela Rosales-Sotomayor, Grecia Figueroa-Ramos, Karla López-López, Judith G. Domínguez-Cherit, Oswaldo San-Martín-Morante, Marcela Saeb-Lima, Armando Gamboa-Domínguez, Alfredo Ponce-de-León, Brenda Crabtree-Ramírez, Pilar Ramos-Cervantes, Guillermo M. Ruíz-Palacios
This case series of 5 patients with severely necrotic mpox highlights the predominantly necrotic nature of lesions seen in cases of severe mpox as shown by skin and lung biopsy, as well as the extensive dissemination of the infection, as shown by polymerase chain reaction (PCR) assessment in different body sites. Patients were male, the median age was 37, all lived with HIV (2 previously undiagnosed)
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Predictors of HIV status disclosure among people living with HIV (PLHIV) in Ghana: the disclosure conundrum and its policy implications in resource limited settings Aids Res. Ther. (IF 2.2) Pub Date : 2023-11-27 Robert Kaba Alhassan, Jerry John Nutor, Akua Gyamerah, Emily Boakye-Yiadom, Emmanuel Kasu, Evelyn Acquah, Emmanuel Doe
Globally, over 40 million lives have been claimed by HIV/AIDS. In Ghana, more than 350,000 people are living with HIV. Non-disclosure of HIV status is a major barrier to HIV/AIDS eradication; yet, little is known of the determinants of HIV status disclosure in resource limited settings in Africa like Ghana. Determine the predictors of HIV status disclosure among people living with HIV (PLHIV) and stimulate
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Standard of care in advanced HIV disease: review of HIV treatment guidelines in six sub-Saharan African countries Aids Res. Ther. (IF 2.2) Pub Date : 2023-11-23 Thomas C. Scheier, Nabila Youssouf, Mosepele Mosepele, Cecilia Kanyama, Olukemi Adekanmbi, Sulaiman Lakoh, Conrad K. Muzoora, Graeme Meintjes, Dominik Mertz, John W. Eikelboom, Sean Wasserman
The World Health Organization (WHO) recommends an evidence-based package of care to reduce mortality and morbidity among people with advanced HIV disease (AHD). Adoption of these recommendations by national guidelines in sub-Saharan Africa is poorly documented. We aimed to review national guidelines for AHD management across six selected countries in sub-Saharan Africa for benchmarking against the
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HIV gp120/Tat protein-induced epithelial–mesenchymal transition promotes the progression of cervical lesions Aids Res. Ther. (IF 2.2) Pub Date : 2023-11-19 Peizhi Wang, Baojun Yang, Huang Huang, Peiyi Liang, Bin Long, Lin Chen, Lijie Yang, Lianhua Tang, Liping Huang, Huichao Liang
Human immunodeficiency virus (HIV) infection is associated with an elevated incidence of cervical cancer, and accelerated disease progression, but the underlying mechanisms are not well understood. This study aimed to investigate the relationship between HIV infection and epithelial–mesenchymal transition (EMT) in cervical cancer. Tissue samples from HIV-positive and negative patients with cervical
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“Sex without fear”: exploring the psychosocial impact of oral HIV pre-exposure prophylaxis on gay men in England Aids Res. Ther. (IF 2.2) Pub Date : 2023-11-14 Rosalie Hayes, Will Nutland, Michael Rayment, Sonali Wayal, Vanesa Apea, Amanda Clarke, Alan McOwan, Ann Sullivan, Monica Desai, Andrew Jajja, Brian Rice, Rob Horne, Sheena McCormack, Mitzy Gafos
Gay, bisexual, and other men who have sex with men (GBMSM) experience a high prevalence of psychosocial health problems, such as harmful substance use and depression, as well as being disproportionately affected by HIV. HIV Pre-Exposure Prophylaxis (PrEP) may provide psychosocial benefits beyond its intended purpose of reducing HIV infection. We explore the psychosocial impact of oral PrEP use on gay
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Qualitative study of barriers and facilitators to HIV detection and treatment among women who inject drugs during the war against Ukraine Aids Res. Ther. (IF 2.2) Pub Date : 2023-11-13 Olena Karagodina, Oksana Kovtun, Myroslava Filippovych, Oleksandr Neduzhko
The Russian Federation’s invasion in Ukraine has resulted social hardship, millions of internally displaced persons, the destruction of medical infrastructure, and limited access to HIV services. There is no available information regarding the impact of the war on the HIV treatment cascade among women who inject drugs (WWID) in Ukraine. In this study, we examine the barriers and facilitators of HIV
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Readmission rates in HIV-associated burkitt lymphoma patients in the USA: a nationwide readmission database (NRD) analysis Aids Res. Ther. (IF 2.2) Pub Date : 2023-11-11 Ashley M. Tuin, Clare M. Wieland, Elizabeth J. Dort, Danielle B. Dilsaver, Manasa Velagapudi
People with human immunodeficiency virus have an increased risk of developing AIDS-defining malignancies including Burkitt lymphoma. Survival outcomes in HIV-associated Burkitt lymphoma remain worse than non-HIV-associated Burkitt lymphoma, despite widespread implementation of antiretroviral therapy. We aimed to determine the association between HIV status and risk for 30-day and 90-day readmission
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Association between psychological discomforts and sleep quality among people living with HIV/AIDS Aids Res. Ther. (IF 2.2) Pub Date : 2023-11-11 Mohammad Ebrahimzadeh Mousavi, Safieh Mohammad Nejad, Maryam Shafaati, Rosa Mykyta-Chomsky, Samaneh Akbarpour, Fatemeh Hadavandsiri
Psychological discomfort and sleep problems are considered separate disorders. Due to the high prevalence of both disorders among people living with HIV (PLWH), this study was designed to evaluate how those challenges are present among PLWH. A cross-sectional study was conducted using data from a national survey of 1185 confirmed PLWH from 15 provinces in Iran from April to August 2019. Psychological
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Uptake of retroviral pre-exposure prophylaxis and its associated factors among female sex workers, Northwest Ethiopia Aids Res. Ther. (IF 2.2) Pub Date : 2023-11-05 Belayneh Fentahun Shibesh, Aragaw Bitew Admas, Amarech Wondie Lake, Samuel Befekadu Getu, Daniel Tarekegn Worede
Pre-exposure prophylaxis is the use of antiretroviral medications by HIV-negative individuals to prevent infection before exposure. Ethiopia has made progress in reducing new HIV infections, but the burden remains high with ongoing challenges in prevention uptake. This study examined the utilization and factors associated with pre-exposure prophylaxis among female sex workers. A community-based cross-sectional
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Strategies to improve the care of older adults 50 years and above living with HIV in Uganda Aids Res. Ther. (IF 2.2) Pub Date : 2023-11-04 Scovia Nalugo Mbalinda, Derrick Amooti Lusota, Martin Muddu, David Musoke, Mathew Nyashanu
With effective antiretroviral therapy (ART), many persons living with HIV (PLHIV) live to old age. Caring for aged PLHIV necessitates the engagement of caregivers and patients to establish agreed-upon goals of treatment. However, there is limited literature on friendly and centered models of care for elderly PLHIV. We explored strategies to improve care in HIV clinics among PLHIV aged 50 years and
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Mixed methods implementation research to understand success of intensive combination approach to roll back the epidemic in Nigerian adolescents) (iCARE Nigeria) HIV testing uptake and linkage to care among young men focusing on young men who have sex with men in Ibadan Aids Res. Ther. (IF 2.2) Pub Date : 2023-10-30 Lisa R. Hirschhorn, Adedotun Adetunji, Aima A. Ahonkhai, Bibilola Oladeji, Olutosin A. Awolude, Lisa M. Kuhns, Jude Onumabor, Kehinde M. Kuti, Olayinka Omigbodun, Amy K. Johnson, Ogochukwu Okonkwor, Babafemi Taiwo, Robert Garofalo
HIV seroprevalence in Nigeria is increasing among men who have sex with men (MSM) from 14% to 2007 to 23% in 2014, threatening progress towards ending the epidemic in the country. Expanding access to HIV testing and linkage to care for key populations, like young MSM (YMSM), is critical to end the HIV epidemic in Nigeria. The Intensive Combination Approach to Roll Back the Epidemic in Nigerian Adolescents
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Current ART, determinants for virologic failure and implications for HIV drug resistance: an umbrella review Aids Res. Ther. (IF 2.2) Pub Date : 2023-10-27 SeyedAhmad SeyedAlinaghi, Amir Masoud Afsahi, Ali Moradi, Zohal Parmoon, Pedram Habibi, Pegah Mirzapour, Mohsen Dashti, Afsaneh Ghasemzadeh, Elaheh Karimi, Foziye Sanaati, Zahra Hamedi, Ayoob Molla, Esmaeil Mehraeen, Omid Dadras
The purpose of this study is to investigate the incidence of determinants for virologic failure and to identify predisposing factors to enhance treatment efficacy. Tackling this global public health issue is the key to reducing the rate of virological failure and increasing the success of treatment for those living with HIV. This umbrella review delves into various aspects of current anti-retroviral
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Preventative behaviours and COVID-19 infection in a Canadian cohort of people living with HIV Aids Res. Ther. (IF 2.2) Pub Date : 2023-10-20 Keely Hammond, Terry Lee, Branka Vulesevic, Joel Singer, Judy Needham, Ann N. Burchell, Hasina Samji, Sharon Walmsley, Mark Hull, Mohammad-Ali Jenabian, Jean-Pierre Routy, Shari Margolese, Enrico Mandarino, Aslam H. Anis, Curtis L. Cooper, Cecilia T. Costiniuk
Few studies have examined preventative behaviour practices with respect to COVID-19 among people living with HIV (human immunodeficiency virus). Using a cross-sectional survey from a Canadian Institutes of Health Research Canadian HIV Trials Network study (CTN 328) of people living with HIV on vaccine immunogenicity, we examined the relationships between participant characteristics and behavioural
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The hidden effects of COVID-19 on HIV services in Zanzibar: country report Aids Res. Ther. (IF 2.2) Pub Date : 2023-10-17 Mansour Maulid Mshenga, Farhat Jowhar Khalid, Shaaban Hassan Haji, Tatu Bilali Ali, Khadija Abbas Mohamed, Damian Jeremia Damian
The COVID-19 pandemic has had a major effect on HIV-related healthcare services. Zanzibar has experienced several interruptions of HIV services in the areas of testing and counselling, prevention of mother-to-child transmission of HIV, key population, care and treatment services as well due to the hospital operating at a reduced capacity and the strict visit restrictions with health care allocations
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Understanding health outcome drivers among adherence club patients in clinics of Gauteng, South Africa: a structural equation modelling (SEM) approach Aids Res. Ther. (IF 2.2) Pub Date : 2023-10-05 Ndumiso Tshuma, Elakpa Daniel Ngbede, Tawanda Nyengerai, Oliver Mtapuri, Sangiwe Moyo, David D. Mphuthi, Peter Nyasulu
There has been growing interest in understanding the drivers of health outcomes, both in developed and developing countries. The drivers of health outcomes, on the other hand, are the factors that influence the likelihood of experiencing positive or negative health outcomes. Human Immunodeficiency Virus (HIV) continues to be a significant global public health challenge, with an estimated 38 million
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Estimating prevalence and modelling correlates of HIV test positivity among female sex workers, men who have sex with men, people who inject drugs, transgender people and prison inmates in Sierra Leone, 2021 Aids Res. Ther. (IF 2.2) Pub Date : 2023-09-27 Duah Dwomoh, Issata Wurie, Yvonne Harding, Kojo Mensah Sedzro, Joseph Kandeh, Henry Tagoe, Christabel Addo, Daniel Kojo Arhinful, Abdul Rahman Cherinoh Sessay, James Lahai Kamara, Kemoh Mansaray, William Kwabena Ampofo
Key populations (KPs) are particularly vulnerable to HIV infection and efforts to prevent HIV infections among KPs have been less successful, largely due to existing laws and legislation that classify the groups as illegal. Understanding the HIV infection pathway and the burden of HIV infection among Female Sex Workers (FSWs), Transgender people (TG), Men who have sex with Men (MSM), People who Inject
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Understanding the social and structural context of oral PrEP delivery: an ethnography exploring barriers and facilitators impacting transgender women who engage in street-based sex work in Baltimore, Maryland Aids Res. Ther. (IF 2.2) Pub Date : 2023-09-20 Erin E. Cooney, Katherine H. A. Footer, Jennifer L. Glick, Anna Passaniti, Meridian Howes, Susan G. Sherman
Transgender women who sell sex (TWSS) experience high rates of HIV acquisition. Antiretrovirals for pre-exposure prophylaxis (PrEP) represent an efficacious HIV prevention strategy. The social and structural factors affecting PrEP delivery amongst TWSS are underexplored in the literature. We conducted ethnographic research to examine how multilevel social and structural factors manifest in TWSS’s lived
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HIV viral load suppression among people with mental disorders at two urban HIV clinics in Uganda: a parallel convergent mixed methods study using the social ecological model Aids Res. Ther. (IF 2.2) Pub Date : 2023-09-19 Regina Ndagire, Rachel Nante Wangi, Kevin Ouma Ojiambo, Joanita Nangendo, Juliet Nakku, Herbert Muyinda, Fred C. Semitala
Uganda adopted and implemented the Universal Test and Treat (UTT) guidelines in 2017, which require HIV-infected persons to be initiated on antiretroviral therapy (ART) at any CD4 + cell count, and to be routinely monitored for viral load to assess response to ART. However, there is paucity of data on viral load suppression (VLS) among people living with HIV (PLHIV) with mental disorders. We conducted
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Tenofovir diphosphate in dried blood spots and HIV-1 resistance in South Africa Aids Res. Ther. (IF 2.2) Pub Date : 2023-09-14 Y. Singh, J. Castillo-Mancilla, R. Madimabe, L. Jennings, C. M. Ferraris, R. N. Robbins, P. L. Anderson, R. H. Remien, C. Orrell
Suboptimal antiretroviral (ART) adherence can lead to virologic failure with consequent HIV-1 resistance. Tenofovir diphosphate (TFV-DP) in dried blood spots (DBS) is a powerful biomarker of cumulative adherence, predictive of future viremia. It has been associated with resistance in Persons With HIV (PWH) in South Africa and the US. We explored the relationship of TFV-DP concentrations with antiretroviral
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HIV-1-related factors interact with p53 to influence cellular processes Aids Res. Ther. (IF 2.2) Pub Date : 2023-09-10 Shanling Liu, Ting Guo, Jinwei Hu, Weiliang Huang, Pengfei She, Yong Wu
Human immunodeficiency virus type 1 (HIV-1) is the primary epidemic strain in China. Its genome contains two regulatory genes (tat and rev), three structural genes (gag, pol, and env), and four accessory genes (nef, vpr, vpu, and vif). Long terminal repeats (LTRs) in thegenome regulate integration, duplication, and expression of viral gene. The permissibility of HIV-1 infection hinges on the host cell
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Dolutegravir use over 48 weeks is not associated with worsening insulin resistance and pancreatic beta cell function in a cohort of HIV-infected Ugandan adults Aids Res. Ther. (IF 2.2) Pub Date : 2023-09-09 Frank Mulindwa, Barbara Castelnuovo, Nele Brusselaers, Martin Nabwana, Robert Bollinger, Allan Buzibye, Eva Laker Agnes Odongpiny, Ronald Kiguba, Jean-Marc Schwarz
The Uganda Ministry of Health issued restrictive guidelines on the use of dolutegravir (DTG) in persons stratified to have a heightened risk of diabetes mellitus. This followed multiple reports of persons with HIV (PWH) presenting with accelerated hyperglycemia after a few weeks to months of exposure to DTG. Having demonstrated a low incidence of diabetes mellitus and improving blood glucose trajectories
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A structural equation modeling approach to investigate HIV testing willingness for men who have sex with men in China Aids Res. Ther. (IF 2.2) Pub Date : 2023-09-03 Han Jiang, Wei He, Haiying Pan, Xiaoni Zhong
A substantial risk of contracting Human immunodeficiency virus (HIV) exists among men who have sex with men (MSM), and HIV infection rates have been rising. This study aimed to analyze the factors influencing the Chinese MSM population’s intention to test for HIV. Nonprobability sampling techniques were employed in June 2022 to recruit MSM in Chongqing and Sichuan, China. The data were analyzed using
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Sustained response following BTK inhibitors based treatment in HIV-related primary central nervous system lymphoma: case report Aids Res. Ther. (IF 2.2) Pub Date : 2023-08-29 Ying Zhou, Xiaoxue Wang, Xuyong Lin, Jun Wang, Xiaojing Yan, Ying Wen
Despite increasing effort for treating primary central nervous system lymphoma (PCNSL), the prognosis of human immunodeficiency virus (HIV) -related PCNSL was still unsatisfactory. There is currently a lack of clinical evidence for the application of Bruton tyrosine kinase (BTK) inhibitor in HIV-related PCNSL. We reported two HIV-related PCNSL patients, who achieved sustained remission by application
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Assessment of satisfaction with antiretroviral drugs and the need for long-acting injectable medicines among people living with HIV in Japan and its associated factors: a prospective multicenter cross-sectional observational study Aids Res. Ther. (IF 2.2) Pub Date : 2023-08-28 Masashi Ishihara, Shinichi Hikasa, Mariko Tsukiji, Yusuke Kunimoto, Kazuko Nobori, Takeshi Kimura, Kenta Onishi, Yuki Yamamoto, Kyohei Haruta, Yohei Kashiwabara, Kenji Fujii, Shota Shimabukuro, Daichi Watanabe, Hisashi Tsurumi, Akio Suzuki
Long-acting injectable formulations for HIV infection have been approved and are now available in Japan. Although not currently recommended as first-line drugs in Japanese or overseas guidelines, use of such formulations may increase, in accordance with patient conditions and preference. We determine the level of satisfaction with current anti-HIV drugs and analyzed the preferences of patients who
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The AIDS and Cancer Specimen Resource (ACSR): HIV malignancy specimens and data available at no cost Aids Res. Ther. (IF 2.2) Pub Date : 2023-08-28 Sylvia Silver, Monika Schmelz
The goal of the AIDS and Cancer Specimen Resource (ACSR) is to play a major role in the advancement of HIV/AIDS cancer-related research/treatment by providing richly annotated biospecimens and data to researchers at no cost. The ACSR acquires, stores, and equitably distributes these samples and associated clinical data to investigators conducting HIV/AIDS-related research, at no costs. Currently, it
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Rescue therapy with an albuvirtide-based antiretroviral regimen in an HIV-infected child with multidrug resistance and multiple opportunistic infections: a case report Aids Res. Ther. (IF 2.2) Pub Date : 2023-08-28 Wei Tang, Xiao-yun Song, Jing Cao, Chun Liu, Fang Zheng
Managing multidrug-resistant (MDR) HIV infections in children is particularly challenging due to the lack of experience with new drugs in the pediatric setting. Second-line albuvirtide (ABT) with an optimized antiretroviral background therapy was approved for adults and adolescents after first-line treatment failure. This paper describes the treatment outcomes and adverse effects of an ABT-based dual-active
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Levels of health literacy among people living with HIV in outpatient care: a cross-sectional study from Denmark Aids Res. Ther. (IF 2.2) Pub Date : 2023-08-26 Lotte Ørneborg Rodkjaer, Merete Storgaard, Nanna Toxvig Sørensen, Liv Marit Valen Schougaard
Low health literacy (HL) among people living with HIV (PLWHIV) encounter more disease related complications, more difficulty understanding health-related information and low adherence. Considering that, the HL levels among PLWHIV needs to be further investigated. The objective of this study was to investigate the levels of HL and patient involvement among PLWHIV in an outpatient clinic in Denmark.
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Retraction Note: Development of attributes and attribute levels for a discrete choice experiment on patients’ and providers’ choice for antiretroviral therapy service in Northwest Ethiopia Aids Res. Ther. (IF 2.2) Pub Date : 2023-08-24 Yihalem Abebe Belay, Mezgebu Yitayal, Asmamaw Atnafu, Fitalew Agimass Taye
AIDS Research and Therapy (2023) 20:33 https://doi.org/10.1186/s12981-023-00531-1 The Editor-in-Chiefs have retracted this article because it contains material that substantially overlaps with the following articles (amongst others) [1, 2]. None of the authors have responded to any correspondence from the editor/publisher about this retraction. Obadha M, Barasa E, Kazungu J, et al. Attribute development
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Pharmacotherapeutic profile, polypharmacy and its associated factors in a cohort of people living with HIV in Brazil Aids Res. Ther. (IF 2.2) Pub Date : 2023-08-21 Robson Pierre Nascimento da Silva, Luana M. S. Marins, Lusiele Guaraldo, Paula Mendes Luz, Sandra W. Cardoso, Ronaldo I. Moreira, Vanessa da Gama Oliveira, Valdilea G. Veloso, Beatriz Grinsztejn, Rita Estrela, Thiago S. Torres
The increased survival provided by the access, development, and evolution of antiretroviral drugs (ARV) greatly increased the life expectancy of people living with HIV (PWH). This has also led to an increased occurrence of diseases or morbidities related to aging. In individuals with multiple comorbidities, the simultaneous use of multiple medications, also known as polypharmacy, is common, and rational
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HIV infection in adult Ugandans with new-onset type 2 diabetes: exploring its influence on the anthropometric and metabolic profile Aids Res. Ther. (IF 2.2) Pub Date : 2023-08-18 Davis Kibirige, Isaac Sekitoleko, Noela Owarwo, Irene Andia-Biraro, William Lumu
HIV infection increases the risk of type 2 diabetes and may influence its phenotypic profile. In this study, we aimed to compare the anthropometric and metabolic characteristics of HIV-infected and uninfected adult Ugandans with new-onset type 2 diabetes to evaluate the influence of HIV infection on specific surrogate markers of adiposity, insulin resistance, and pancreatic beta-cell function. We consecutively
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Heart transplantation and human immunodeficiency virus–navigating drug-drug interactions: a case report Aids Res. Ther. (IF 2.2) Pub Date : 2023-08-11 Thamer A. Almangour, Preston T. Skersick, Amanda Corbett, Jo E. Rodgers, Patricia P. Chang, Claire E. Farel
Antiretroviral therapy (ART) has led to a decline in human immunodeficiency virus (HIV)-related mortality, but comorbidities, including organ dysfunction, are increasingly the focus of care. Heart transplant (HT) is a very effective therapeutic strategy for end-stage heart failure (HF); however, clinicians may be hesitant due to concerns of complex drug-drug interactions (DDIs) between ART and HT immunosuppressive
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Managing household income and antiretroviral therapy adherence among people living with HIV in a low-income setting: a qualitative data from the HPTN 071 (PopART) trial in South Africa Aids Res. Ther. (IF 2.2) Pub Date : 2023-08-04 Abenathi Mcinziba, Peter Bock, Graeme Hoddinott, Janet Seeley, Virginia Bond, Sarah Fidler, Lario Viljoen
South Africa is reported to have the highest burden of HIV with an estimated 8.2 million people living with HIV (PLHIV) in 2021- despite adopting the World Health Organisation (WHO) universal HIV test and treat (UTT) recommendations in 2016. As of 2021, only an estimated 67% (5.5 million) of all PLHIV were accessing antiretroviral therapy (ART), as per recorded clinic appointments attendance. Studies
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Increased human immunodeficiency virus viral load with cerebral infarction due to varicella zoster virus vasculopathy on treatment with bictegravir/emtricitabine/tenofovir alafenamide suspension: a case report and literature review Aids Res. Ther. (IF 2.2) Pub Date : 2023-07-30 Kazuhiro Ishikawa, Fujimi Kawai, Nobuyoshi Mori
Varicella-Zoster virus (VZV) vasculopathy occasionally occurs in immunocompromised patients and is difficult to treat. The risk factor and optimal therapy remain unclear. Patients with human immunodeficiency virus (HIV) and dysphagia or difficulty in oral intake receive antiretroviral therapy (ART) suspension. However, there remains little evidence regarding ART suspension. We experienced a case of
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Intimate partner violence against HIV-Positive women on ART follow-up and associated factors in public health facilities of western Ethiopia Aids Res. Ther. (IF 2.2) Pub Date : 2023-07-25 Shibiru Biranu, Motuma Getachew, Gemechu Kejela, Chaltu Kifilu
Intimate partner violence is the most pervasive but less recognized problem which affects millions of women world. It is more common among marginalized individuals including women affected by HIV. However, there is limited information regarding this problem among HIV-Positive Women in Ethiopia. Thus, the study was aimed to assess the magnitude and factors associated with intimate partner violence among
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Biomedical association analysis between G2/M checkpoint genes and susceptibility to HIV-1 infection and AIDS progression from a northern chinese MSM population Aids Res. Ther. (IF 2.2) Pub Date : 2023-07-19 Jiawei Wu, Lidan Xu, Bangquan Liu, Wenjing Sun, Yuanting Hu, Yi Yang, Keer Guo, Xueyuan Jia, Haiming Sun, Jie Wu, Yun Huang, Wei Ji, Songbin Fu, Yuandong Qiao, Xuelong Zhang
MSM are at high risk of HIV infection. Previous studies have shown that the cell cycle regulation plays an important role in HIV-1 infection, especially at the G2/M checkpoint. ATR, Chk1, Cdc25C and CDK1 are key genes of G2/M checkpoint. However, the association between SNPs of these genes and susceptibility to HIV-1 infection and AIDS progression remains unknown. In this study, 42 tSNPs from the above
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Cytomegalovirus colitis unmasking human immunodeficiency virus infection as a cause of IgA vasculitis Aids Res. Ther. (IF 2.2) Pub Date : 2023-07-19 Alice Bartoletti, Paolo Delvino, Marco Minetto, Alessandra Milanesi, Emanuele Bozzalla Cassione, Verdiana Serena Quadrelli, Ombretta Luinetti, Sara Monti, Carlomaurizio Montecucco
Human immunodeficiency virus (HIV) has a protean clinical picture, in rare instances manifesting as systemic autoimmune disorders such as vasculitides. HIV-induced autoimmune diseases often do not respond well to systemic immunosuppressive therapy. Opportunistic infections may occur in patients with either acquired immunodeficiency syndrome (AIDS) or heavy immunosuppressive treatment, and can further
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Prevalence and risk factors for kidney disease among hospitalized PLWH in China Aids Res. Ther. (IF 2.2) Pub Date : 2023-07-15 Naxin Zhao, Pan Xiang, Zhili Zeng, Hongyuan Liang, Fang Wang, Jiang Xiao, Di Yang, Sa Wang, Meiling Chen, Guiju Gao
Kidney disease is an important comorbidity in people living with HIV(PLWH), and is associated with poor outcomes. However, data on renal function of PLWH are limited in China so far. In this study we assessed the prevalence of kidney disease in patients either on antiretroviral therapy (ART) or not respectively in a single center in China and explored the possible risk factors associated. In the cross-sectional
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Unmasked immune reconstitution inflammatory syndrome towards B-cell non-Hodgkin lymphoma during treatment of esophageal actinomycosis in a patient with advanced HIV: a case report Aids Res. Ther. (IF 2.2) Pub Date : 2023-07-14 Elsa K. Vargas-Garcia, Augusto R. Fernandez-Aristi, Gonzalo Cornejo-Venegas, Juan José Montenegro-Idrogo, Juan Chirinos-Vega, Alfredo Chiappe-Gonzalez
Actinomycosis is an unusual chronic bacterial infection, even rarer in people living with HIV. It is not considered an AIDS-defining disease. However, the role in co-presentation or overlap with other opportunistic conditions of advanced HIV is unknown. A 49-year-old Peruvian male presented with a 4-month history of dysphagia, odynophagia, hyporexia and wasting. He underwent an upper digestive endoscopy
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What are the determinants of antiretroviral therapy adherence among stable people living with HIV? A cross-sectional study in Cambodia Aids Res. Ther. (IF 2.2) Pub Date : 2023-07-14 Sovannary Tuot, Jian Wei Sim, Michiko Nagashima-Hayashi, Pheak Chhoun, Alvin Kuo Jing Teo, Kiesha Prem, Siyan Yi
Understanding context-specific determinants of antiretroviral therapy (ART) adherence is crucial for developing tailored interventions for improving health outcomes and achieving the UNAIDS’ third 95% target. This cross-sectional study explores factors associated with ART adherence among stable people living with HIV on ART in Cambodia. We used baseline survey data from a quasi-experimental study conducted