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Using Data-to-Care Strategies to Optimize the HIV Care Continuum in Connecticut: Results from a Randomized Controlled Trial J. Acquir. Immune Defic. Syndr. (IF 3.6) Pub Date : 2024-02-07 Eteri Machavariani, Janet Miceli, Frederick L. Altice, Robyn Neblett Fanfair, Suzanne Speers, Lisa Nichols, Heidi Jenkins, Merceditas Villanueva
Background: Re-engaging people with HIV (PWH) who are newly out-of-care remains challenging. Data-to-care (D2C) is a potential strategy to re-engage such individuals. Methods: A prospective randomized controlled trial compared a D2C strategy using a disease intervention specialist (DIS) vs standard-of-care (SOC) where 23 HIV clinics in 3 counties in Connecticut could re-engage clients using existing
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Differentiated service delivery framework for people with multidrug-resistant tuberculosis and HIV co-infection J. Acquir. Immune Defic. Syndr. (IF 3.6) Pub Date : 2024-02-07 Karl Reis, Allison Wolf, Rubeshan Perumal, Boitumelo Seepamore, Kevin Guzman, Jesse Ross, Ken Cheung, K. Rivet Amico, James C.M. Brust, Nesri Padayatchi, Gerald Friedland, Kogieleum Naidoo, Amrita Daftary, Jennifer Zelnick, Max O’Donnell
Introduction For people living with HIV/AIDS, care is commonly delivered through Differentiated Service Delivery (DSD). Although people with multidrug-resistant tuberculosis (MDR-TB) and HIV/AIDS experience severe treatment associated challenges, there is no DSD model to support their treatment. In this study, we defined patterns of medication adherence and characterized longitudinal barriers to inform
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Low rates of side effects in paclitaxel chemotherapy for Kaposi sarcoma and feasibility of treatment in outpatient ART clinic settings in Malawi J. Acquir. Immune Defic. Syndr. (IF 3.6) Pub Date : 2024-02-07 Ethel Rambiki, Tom Heller, Claudia Wallrauch, Matthew Painschab, Jacquiline Huwa, Jennipher Khalani, Kelvin Rambiki
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Prevalence and Correlates of Intimate Partner Violence Victimization Among Urban Adolescents and Young Adults Living With Perinatally-Acquired HIV Infection or Perinatal HIV Exposure J. Acquir. Immune Defic. Syndr. (IF 3.6) Pub Date : 2024-01-12 Naa-Djama Attoh-Okine, Tom Corbeil, Ohemaa Poku, Luke Kluisza, Lucy Liotta, Corey Morrison, Curtis Dolezal, Reuben N. Robbins, Philip Kreniske, Elaine J. Abrams, Andrew Wiznia, Claude A. Mellins
Introduction: Because of privacy and ethical concerns, the data cannot be made available because of the sensitivity of the HIV data and the relatively small sample and ease of identifying people if a few demographics are known. Few studies have examined intimate partner violence (IPV) victimization among adolescents and young adults (AYAs) with perinatally acquired HIV-infection (PHIV) or perinatal
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Brief Report: In cART-Treated HIV-Infected Patients, Immunologic Failure Is Associated With a High Myeloid-Derived Suppressor Cell Frequency J. Acquir. Immune Defic. Syndr. (IF 3.6) Pub Date : 2024-01-12 Germana Grassi, Stefania Notari, Stefania Cicalini, Rita Casetti, Eleonora Cimini, Veronica Bordoni, Roberta Gagliardini, Valentina Mazzotta, Andrea Antinori, Chiara Agrati, Alessandra Sacchi
Background: During HIV infection, effective combined antiretroviral therapy suppresses viral replication and restores the number of circulating CD4+ T cells. However, 15%–30% of treated patients show a discordant response to combined antiretroviral therapy. Myeloid-derived suppressor cells (MDSC) are expanded in HIV+ patients; to better understand the role of MDSC on CD4 T-cell recovery, we evaluated
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Facility-Based Indicators to Manage and Scale Up Cervical Cancer Prevention and Care Services for Women Living With HIV in Sub-Saharan Africa: a Three-Round Online Delphi Consensus Method J. Acquir. Immune Defic. Syndr. (IF 3.6) Pub Date : 2024-01-12 Maša Davidović, Serra Lem Asangbeh, Katayoun Taghavi, Tafadzwa Dhokotera, Antoine Jaquet, Beverly Musick, Cari Van Schalkwyk, David Schwappach, Eliane Rohner, Gad Murenzi, Kara Wools-Kaloustian, Kathryn Anastos, Orang'o Elkanah Omenge, Simon Pierre Boni, Stephany N. Duda, Per von Groote, Julia Bohlius
Background: Of women with cervical cancer (CC) and HIV, 85% live in sub-Saharan Africa, where 21% of all CC cases are attributable to HIV infection. We aimed to generate internationally acceptable facility-based indicators to monitor and guide scale up of CC prevention and care services offered on-site or off-site by HIV clinics. Methods: We reviewed the literature and extracted relevant indicators
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Updated Data and Methods for the 2023 UNAIDS HIV Estimates J. Acquir. Immune Defic. Syndr. (IF 3.6) Pub Date : 2024-01-05 Cari van Schalkwyk, Mary Mahy, Leigh F. Johnson, Jeffrey W. Imai-Eaton
Abstract: Each year, supported by the Joint United Nations Programme on HIV/AIDS (UNAIDS), country teams across the globe produce estimates that chart the state of their HIV epidemics. In 2023, HIV estimates were available for 174 countries, accounting for 99% of the global population, of which teams from 150 countries actively engaged in this process. The methods used to derive these estimates are
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Impact of Genetic Variants in ABCG2, NR1I2 and UGT1A1 on the Pharmacokinetics of Dolutegravir in Children J. Acquir. Immune Defic. Syndr. (IF 3.6) Pub Date : 2024-01-05 Stephen A. Spector, Sean S. Brummel, Audrey Chang, Andrew Wiznia, Theodore D. Ruel, Edward P. Acosta
Background: Dolutegravir plasma concentrations and pharmacokinetic (PK) parameters in children display considerable variability. Here, the impact of genetic variants in ABCG2 421C>A (rs2231142), NR1I2 63396 C>T (rs2472677) and UGT1A1 (rs5839491) on dolutegravir PK was examined. Methods: Children defined by age and administered dolutegravir formulation had AUC24 at steady state, Cmax and C24h determined
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Measuring HIV Acquisitions Among Partners of Key Populations: Estimates From HIV Transmission Dynamic Models J. Acquir. Immune Defic. Syndr. (IF 3.6) Pub Date : 2024-01-05 Romain Silhol, Rebecca L. Anderson, Oliver Stevens, James Stannah, Ross D. Booton, Stefan Baral, Dobromir Dimitrov, Kate M. Mitchell, Deborah Donnell, Anna Bershteyn, Tim Brown, Sherrie L. Kelly, Hae-Young Kim, Leigh F. Johnson, Mathieu Maheu-Giroux, Rowan Martin-Hughes, Sharmistha Mishra, Wiwat Peerapatanapokin, Jack Stone, John Stover, Yu Teng, Peter Vickerman, Sonia Arias Garcia, Eline Korenromp
Background: Key populations (KPs), including female sex workers (FSWs), gay men and other men who have sex with men (MSM), people who inject drugs (PWID), and transgender women (TGW) experience disproportionate risks of HIV acquisition. The UNAIDS Global AIDS 2022 Update reported that one-quarter of all new HIV infections occurred among their non-KP sexual partners. However, this fraction relied on
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Triangulation of Routine Antenatal HIV Prevalence Data and Adjusted HIV Estimates in Mozambique J. Acquir. Immune Defic. Syndr. (IF 3.6) Pub Date : 2024-01-05 Oliver Stevens, Makini Boothe, Orrin Tiberi, Mary Mahy, Patrick Walker, Robert Glaubius, Jordan McOwen, Aleny Couto, Morais Cunha, Jeffrey W. Imai-Eaton
Background: Routine health system data are central to monitoring HIV trends. In Mozambique, the reported number of women receiving antenatal care (ANC) and antiretroviral therapy for prevention of mother-to-child transmission (PMTCT) has exceeded the Spectrum-estimated number of pregnant women since 2017. In some provinces, reported HIV prevalence in pregnant women has declined faster than epidemiologically
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Estimation of Improvements in Mortality in Spectrum Among Adults With HIV Receiving Antiretroviral Therapy in High-Income Countries J. Acquir. Immune Defic. Syndr. (IF 3.6) Pub Date : 2024-01-05 Adam Trickey, Robert Glaubius, Nikos Pantazis, Robert Zangerle, Linda Wittkop, Janne Vehreschild, Sophie Grabar, Matthias Cavassini, Ramon Teira, Antonella d’Arminio Monforte, Jordi Casabona, Ard van Sighem, Inma Jarrin, Suzanne M. Ingle, Jonathan A. C. Sterne, Jeffrey W. Imai-Eaton, Leigh F. Johnson
Introduction: Mortality rates for people living with HIV (PLHIV) on antiretroviral therapy (ART) in high-income countries continue to decline. We compared mortality rates among PLHIV on ART in Europe for 2016–2020 with Spectrum's estimates. Methods: The AIDS Impact Module in Spectrum is a compartmental HIV epidemic model coupled with a demographic population projection model. We used national Spectrum
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ASSOCIATION OF ANDROGEN HORMONES, SEX HORMONE BINDING GLOBULIN, AND THE MENOPAUSAL TRANSITION WITH INCIDENT DIABETES MELLITUS IN WOMEN WITH AND WITHOUT HIV J. Acquir. Immune Defic. Syndr. (IF 3.6) Pub Date : 2024-01-05 Rebecca A. ABELMAN, Michael F. SCHNEIDER, Christopher COX, Geralyn MESSERLIAN, Mardge COHEN, Deborah GUSTAFSON, Michael PLANKEY, Anjali SHARMA, Jennifer PRICE, Carl GRUNFELD, Phyllis C. TIEN
Background: HIV is associated with alterations in androgen hormone levels and sex hormone binding globulin (SHBG) in women. Higher SHBG has been associated with a lower risk of diabetes in the general population, but the contribution of HIV, androgen hormones, SHBG, and menopausal phase to diabetes is unclear. Methods: From April 2003 through February 2020, 896 women with HIV (WWH) and 343 women without
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Differences in Breastfeeding Duration by Maternal HIV Status: A Pooled Analysis of Nationally Representative Surveys in Sub-Saharan Africa J. Acquir. Immune Defic. Syndr. (IF 3.6) Pub Date : 2024-01-05 Robert Glaubius, John Stover, Leigh F. Johnson, Severin G. Mahiane, Mary I. Mahy, Jeffrey W. Eaton
Background: Breastfeeding improves child survival but is a source of mother-to-child HIV transmission among women with unsuppressed HIV infection. Estimated HIV incidence in children is sensitive to breastfeeding duration among mothers living with HIV (MLHIV). Breastfeeding duration may vary according to maternal HIV status. Setting: Sub-Saharan Africa. Methods: We analyzed pooled data from nationally
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Temporal Trends and Determinants of HIV Testing at Antenatal Care in Sub-Saharan Africa: A Pooled Analysis of Population-Based Surveys (2005–2021) J. Acquir. Immune Defic. Syndr. (IF 3.6) Pub Date : 2024-01-05 Adrien Allorant, Paul Muset, Caroline Hodgins, Fati Kirakoya-Samadoulougou, Khumbo Namachapa, Francisco Mbofana, Dimitra Panagiotoglou, Leigh F. Johnson, Jeffrey W. Imai-Eaton, Mathieu Maheu-Giroux
Background: In sub-Saharan Africa (SSA), integrating HIV testing into antenatal care (ANC) has been crucial toward reducing mother-to-child transmission of HIV. With the introduction of new testing modalities, we explored temporal trends in HIV testing within and outside of ANC and identified sociodemographic determinants of testing during ANC. Methods: We analyzed data from 139 nationally representative
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The AIDS Epidemic Model 2023 for Estimating HIV Trends and Transmission Dynamics in Asian Epidemic Settings J. Acquir. Immune Defic. Syndr. (IF 3.6) Pub Date : 2024-01-05 Tim Brown, Wiwat Peerapatanapokin, Nalyn Siripong, Robert Puckett
Background: Thirteen Asian countries use the AIDS Epidemic Model (AEM) as their HIV model of choice. This article describes AEM, its inputs, and its application to national modeling. Setting: AEM is an incidence tool used by Spectrum for the Joint United Nations Programme on HIV/AIDS global estimates process. Methods: AEM simulates transmission of HIV among key populations (KPs) using measured trends
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Improved Indicators for Subnational Unmet Antiretroviral Therapy Need in the Health System: Updates to the Naomi Model in 2023 J. Acquir. Immune Defic. Syndr. (IF 3.6) Pub Date : 2024-01-05 Rachel Esra, Mpho Mmelesi, Akeem T. Ketlogetswe, Timothy M. Wolock, Adam Howes, Tlotlo Nong, Matshelo Tina Matlhaga, Siphiwe Ratladi, Dinah Ramaabya, Jeffrey W. Imai-Eaton
Background: Quantifying subnational need for antiretroviral therapy (ART) for HIV is challenging because people living with HIV (PLHIV) access health facilities in areas that may differ from their residence. We defined and demonstrated new indicators for PLHIV treatment needed to guide health system target setting and resource allocation. Setting: Botswana. Methods: We extended Naomi, a Bayesian small-area
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Comparison of Empirically Derived and Model-Based Estimates of Key Population HIV Incidence and the Distribution of New Infections by Population Group in Sub-Saharan Africa J. Acquir. Immune Defic. Syndr. (IF 3.6) Pub Date : 2024-01-05 Oliver Stevens, Rebecca Anderson, John Stover, Yu Teng, James Stannah, Romain Silhol, Harriet Jones, Ross D. Booton, Rowan Martin-Hughes, Leigh Johnson, Mathieu Maheu-Giroux, Sharmistha Mishra, Jack Stone, Anna Bershteyn, Hae-Young Kim, Keith Sabin, Kate M. Mitchell, Dobromir Dimitrov, Stefan Baral, Deborah Donnell, Eline Korenromp, Brian Rice, James R. Hargreaves, Peter Vickerman, Marie-Claude Boily
Background: The distribution of new HIV infections among key populations, including female sex workers (FSWs), gay men and other men who have sex with men (MSM), and people who inject drugs (PWID) are essential information to guide an HIV response, but data are limited in sub-Saharan Africa (SSA). We analyzed empirically derived and mathematical model-based estimates of HIV incidence among key populations
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CMV IgG is Associated with Physical Function but not Muscle Density in People with HIV J. Acquir. Immune Defic. Syndr. (IF 3.6) Pub Date : 2024-01-05 Maheen Z. Abidi, Triin Umbleja, Edgar T. Overton, Tricia Burdo, Jacqueline M. Flynn, Michael T. Lu, Jana Taron, Samuel R. Schnittman, Kathleen V. Fitch, Markella V. Zanni, Carl J. Fichtenbaum, Carlos Malvestutto, Judith A. Aberg, Evelynne S. Fulda, Allison Ross Eckard, Jennifer Manne-Goehler, Jessica J. Tuan, Heather J. Ribaudo, Pamela S. Douglas, Steven K. Grinspoon, Todd T. Brown, Kristine M. Erlandson
Background: Cytomegalovirus (CMV) seropositivity is associated with poor outcomes, including physical function impairment, in people without HIV. We examined associations between CMV IgG titer and physical function in virologically suppressed people with HIV (PWH). Methods: REPRIEVE is a double-blind randomized trial evaluating pitavastatin for primary prevention of atherosclerotic cardiovascular disease
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Predicting lost to follow-up status using an adolescent HIV psychosocial attrition risk assessment tool: Results from a mixed methods prospective cohort study in Uganda J. Acquir. Immune Defic. Syndr. (IF 3.6) Pub Date : 2024-01-05 Naomi Medina-Jaudes, Dennis Adoa, Amanda Williams, Catherine Amulen, Andy Carmone, Stephanie Dowling, Jessica Joseph, Cordelia Katureebe, Vennie Nabitaka, Andrew Musoke, Eleanor Namusoke Magongo, Teddy Nabwire Chimulwa
Background: Low retention in care for adolescents living with HIV (ALHIV) has been a key driver of sub-optimal viral load suppression rates in Uganda. The objective of the study was to develop a psychosocial risk assessment tool and evaluate its ability to predict risk of attrition of ALHIV between the ages of 15 and 19. Setting: The study was conducted in 20 facilities in Central and Western Uganda
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Methods and Assumptions for Estimating Key HIV Indicators in the UNAIDS Annual Estimates Process J. Acquir. Immune Defic. Syndr. (IF 3.6) Pub Date : 2024-01-05 John Stover, Robert Glaubius
Background: Each year UNAIDS supports national teams to estimate key HIV indicators using their latest data. These estimates are produced using a collection of models and software tools. This paper describes the demographic and HIV projection models used in this process. Methods: The demographic model (DemProj) projects the population by sex and single age for each year of the estimate. This information
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Longitudinal Associations of Experienced and Perceived Community Stigma with ART Adherence and Viral Suppression in New-to-care People with HIV: Mediating Roles of Internalized Stigma and Depression Symptoms J. Acquir. Immune Defic. Syndr. (IF 3.6) Pub Date : 2024-01-05 Ibrahim YIGIT, Bulent TURAN, Gülşah KURT, Sheri D. WEISER, Mallory O. JOHNSON, Michael J. MUGAVERO, Janet M. TURAN
Background: While cross-sectional studies have suggested that HIV-related stigma and depression symptoms may result in poor HIV treatment and health outcomes, few studies have investigated potential longitudinal mechanisms in these relationships. Furthermore, longitudinal effects of HIV-related stigma on health outcomes have not been examined in people with HIV (PWH) newly initiating HIV clinical care
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New HIV Infections Among Key Populations and Their Partners in 2010 and 2022, by World Region: A Multisources Estimation J. Acquir. Immune Defic. Syndr. (IF 3.6) Pub Date : 2024-01-05 Eline L. Korenromp, Keith Sabin, John Stover, Tim Brown, Leigh F. Johnson, Rowan Martin-Hughes, Debra ten Brink, Yu Teng, Oliver Stevens, Romain Silhol, Sonia Arias-Garcia, Joshua Kimani, Robert Glaubius, Peter Vickerman, Mary Mahy
Background: Previously, The Joint United Nations Programme on HIV/AIDS estimated proportions of adult new HIV infections among key populations (KPs) in the last calendar year, globally and in 8 regions. We refined and updated these, for 2010 and 2022, using country-level trend models informed by national data. Methods: Infections among 15–49 year olds were estimated for sex workers (SWs), male clients
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Factors Associated with COVID-19 Vaccination among Racial/Ethnic Minority Groups with HIV in South Florida J. Acquir. Immune Defic. Syndr. (IF 3.6) Pub Date : 2023-12-22 Daisy Ramírez-Ortiz, Michele Jean-Gilles, Diana M. Sheehan, Robert Ladner, Tan Li, Mary Jo Trepka
Background: Racial/ethnic minority groups with HIV in the United States are particularly vulnerable to COVID-19 consequences and can significantly benefit from increased uptake of COVID-19 vaccines. This study identified factors associated with full COVID-19 vaccination among people with HIV. Setting: Ryan White HIV/AIDS Program (RWP) in Miami-Dade County, Florida. Methods: Data were collected from
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Effectiveness of PrEPTECH: Findings from a 180-Day Randomized Controlled Trial of a Pre-Exposure Prophylaxis Telehealth Intervention J. Acquir. Immune Defic. Syndr. (IF 3.6) Pub Date : 2023-12-22 Rebecca K Erenrich, Rebecca A Braun, David M Torres-Mendoza, Olivia L Stevenson, Thuan-Huong P Doan, Jeffrey D Klausner
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Unmet needs for HIV ancillary services among persons with diagnosed HIV aged 55 years and older J. Acquir. Immune Defic. Syndr. (IF 3.6) Pub Date : 2023-12-22 Kathy K. Byrd, Kate Buchacz, Stacy M. Crim, Linda Beer, Jen-Feng Lu, Sharoda Dasgupta
Background: Approximately two in five persons with HIV (PWH) in the United States are aged ≥55 years. HIV ancillary services, such as case management and transportation services, can help older PWH remain engaged in care. We used data from the Medical Monitoring Project (MMP) to describe the prevalence of unmet needs for ancillary services among persons with diagnosed HIV aged ≥55 years. Setting: Medical
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Associations between Estimates of Arterial Stiffness and Cognitive Functioning in Adults with HIV J. Acquir. Immune Defic. Syndr. (IF 3.6) Pub Date : 2023-12-22 Raymond Jones, Matthew B. Jessee, Robert Booker, Samantha L. Martin, David E. Vance, Pariya L. Fazeli
Background: Vascular aging, a precursor of arterial stiffness, is associated with neurocognitive impairment (NCI) and cardiovascular disease (CVD). Although HIV is associated with rapid vascular aging, it is unknown whether arterial stiffness mediates changes in cognitive function. We explored whether estimated markers of vascular aging were associated with NCI indices in HIV-positive individuals.
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Intimate partner violence and adherence to PrEP and ART among Ugandan HIV serodifferent couples J. Acquir. Immune Defic. Syndr. (IF 3.6) Pub Date : 2023-12-22 Dorothy Thomas, Lylianne Nakabugo, Florence Nambi, Joseph Kibuuka, Timothy Muwonge, Erika Feutz, Katherine Thomas, Jane Simoni, Elizabeth Montgomery, Norma Ware, Monique Wyatt, Ingrid T. Katz, Herbert Kadama, Andrew Mujugira, Renee Heffron
Background: Intimate partner violence (IPV) is associated with increased risk of HIV acquisition and reduced engagement in HIV care. There is limited understanding of the ways in which IPV exposure and other maladaptive relationship dynamics may influence adherence to antiretroviral treatment (ART) and pre-exposure prophylaxis (PrEP) for individuals in committed, HIV serodifferent partnerships. Methods
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The role of substance use in structural heart disease among women living with HIV J. Acquir. Immune Defic. Syndr. (IF 3.6) Pub Date : 2023-12-22 Elise D. Riley, Eric Vittinghoff, Akshay Ravi, Phillip O. Coffin, Kara Lynch, Alan H.B. Wu, Claudia Martinez, Priscilla Y. Hsue
BACKGROUND: People living with HIV have increased risk of cardiovascular disease, but few studies focus on women with HIV (WWH) and few account for the use of multiple substances SETTING: We recruited WWH from San Francisco shelters, free meal programs, street encampments and a safety net HIV clinic. METHODS: Between 2016 and 2019, participants completed six monthly interviews, specimen collection
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PREDICTORS OF MORTALITY AMONG CHILDREN AND ADOLESCENTS LIVING WITH HIV ON ANTIRETROVIRAL THERAPY IN WESTERN KENYA J. Acquir. Immune Defic. Syndr. (IF 3.6) Pub Date : 2023-12-22 Winstone Nyandiko, Njie Albertine Enjema, Richard Mugo, Edith Apondi, Edwin Sang, Ann Mwangi
Background: Antiretroviral therapy (ART) has decreased HIV-attributable deaths; however, children and adolescents continue to have high HIV-associated mortality. Setting: We determined the predictors of death among children and young adolescents living with HIV (CALWH) who died while in care in Western Kenya. Methods: This retrospective case-control study used electronically abstracted data of 6234
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Alcohol consumption and illicit drug use: associations with fall, fracture, and acute healthcare utilization among people with HIV infection J. Acquir. Immune Defic. Syndr. (IF 3.6) Pub Date : 2023-12-22 Theresa W. Kim, Nicolas Bertholet, Kara M. Magane, Christine Lloyd-Travaglini, Michael R. Winter, Jeffrey H. Samet, Kristine M. Erlandson, Michael D. Stein, Kendall J. Bryant, Richard Saitz, Timothy C. Heeren
Background: Given alcohol and/or other drug (AOD) use occurs among people with HIV (PWH), we examined its association with falls and fall-related outcomes and if frailty moderates the association. Setting: Northeastern US city. Methods: We analyzed an observational cohort of PWH with current or past AOD use. Alcohol measures were any past 14-day heavy use, average alcohol/day, and days with heavy use
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Barriers and Facilitators to Long-Acting Injectable HIV PrEP Implementation in Primary Care Since Its Approval in the United States J. Acquir. Immune Defic. Syndr. (IF 3.6) Pub Date : 2023-12-22 Shimrit Keddem, Sneha Thatipelli, Omaris Caceres, Navid Roder, Florence Momplaisir, Peter Cronholm
Background: HIV pre-exposure prophylaxis (PrEP) is a highly effective method to mitigate the HIV epidemic, but uptake of PrEP has been slow and is associated with racial and gender disparities. Oral PrEP requires high levels of adherence to be effective, which may disadvantage certain high-risk groups. The first injectable HIV PrEP, a drug given every two months rather than as a daily pill, was approved
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Substance Use Care Continuum in Women with and without HIV in the Southern United States J. Acquir. Immune Defic. Syndr. (IF 3.6) Pub Date : 2023-12-22 Aditi Ramakrishnan, Ayako W. Fujita, C. Christina Mehta, Tracey E. Wilson, Steve Shoptaw, Adam Carrico, Adaora A. Adimora, Ellen F. Eaton, Deborah L. Jones, Aruna Chandran, Anandi N. Sheth
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Relationship between adiposity and biomarkers of aging and frailty among adults aging with HIV J. Acquir. Immune Defic. Syndr. (IF 3.6) Pub Date : 2023-12-15 Vitor HF Oliveira, Amanda L Willig, Christine Horvat Davey, Thomas W Buford, Prema Menezes, Edward Cachay, Heidi M Crane, Greer A Burkholder, Barbara M Gripshover, Julia G Fleming, John D Cleveland, Allison R Webel
Background: This study examined the relationships among adiposity, handgrip, physical function, inflammation (i.e., senescence-associated secretory phenotype [SASP] chemokines as biomarkers of aging and frailty), and sex hormones in aging people with HIV (PWH). Methods: This cross-sectional exploratory study included 150 PWH aged ≥40 years (67.3% of participants were males). Our measures included:
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RELATIONSHIP BETWEEN VITAMIN D DEFICIENCY AND NON-ALCOHOLIC FATTY LIVER DISEASE IN PATIENTS WITH HIV-1 INFECTION J. Acquir. Immune Defic. Syndr. (IF 3.6) Pub Date : 2023-12-15 Leonardo Calza, Maddalena Giglia
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Randomized Trial of a “Dynamic Choice” Patient-Centered Care Intervention for Mobile Persons With HIV in East Africa J. Acquir. Immune Defic. Syndr. (IF 3.6) Pub Date : 2023-12-06 James Ayieko, Laura B. Balzer, Colette Inviolata, Elijah Kakande, Fred Opel, Erick M. Wafula, Jane Kabami, Asiphas Owaraganise, Florence Mwangwa, Hellen Nakato, Elizabeth A. Bukusi, Carol S. Camlin, Edwin D. Charlebois, Melanie C. Bacon, Maya L. Petersen, Moses R. Kamya, Diane V. Havlir, Gabriel Chamie
Background: Persons with HIV (PWH) with high mobility face obstacles to HIV care engagement and viral suppression. We sought to understand whether a patient-centered intervention for mobile PWH would improve viral suppression and retention in care, and if so, which subgroups would benefit most. Methods: In a randomized trial, we evaluated the effect of an intervention designed to address barriers to
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Cofactors of partner HIV self-testing and Oral PrEP acceptance among pregnant women at high risk of HIV in Kenya J. Acquir. Immune Defic. Syndr. (IF 3.6) Pub Date : 2023-11-30 Nancy M. NGUMBAU, Jillian NEARY, Anjuli D WAGNER, Felix ABUNA, Ben OCHIENG, Julia C DETTINGER, Laurén GÓMEZ, Mary M. MARWA, Salphine WATOYI, Emmaculate NZOVE, Jillian PINTYE, Jared M. BAETEN, John KINUTHIA, Grace JOHN-STEWART
Background: Oral PrEP and male partner HIV self-testing (HIVST) is being scaled up within antenatal clinics (ANC). Few data are available on how co-distribution influences acceptance of both interventions. Methods: We utilized data from the PrIMA (NCT03070600) trial in Kenya. Women included in this analysis were determined to be at high risk of HIV and offered oral PrEP and partner HIVST. Characteristics
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Impact of decarceration plus alcohol, substance use, and mental health screening on life expectancies of Black sexual minority men and Black transgender women (BSMM/BTW) living with HIV in the United States: A Simulation Study based on HPTN 061 J. Acquir. Immune Defic. Syndr. (IF 3.6) Pub Date : 2023-11-30 Jonathan Feelemyer, Anna Bershteyn, Joy D. Scheidell, Russell Brewer, Typhanye V Dyer, Charles M Cleland, Christopher Hucks-Ortiz, Amy Justice, Ken Mayer, Ames Grawert, Jay S. Kaufman, Scott Braithwaite, Maria R Khan
Background Given the disproportionate rates of incarceration and lower life expectancy (LE) among Black sexual minority men (BSMM) and Black transgender women (BTW) with HIV, we modeled the impact of decarceration and screening for psychiatric conditions and substance use on LE of US BSMM/BTW with HIV. Methods We augmented a microsimulation model previously validated to predict LE and leading causes
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Polysubstance Use Profiles and HIV Viremia in a South African Cohort of Female Sex Workers: A Latent Class Analysis J. Acquir. Immune Defic. Syndr. (IF 3.6) Pub Date : 2023-11-30 Joseph G. Rosen, Justin R. Knox, Katherine B. Rucinski, Mfezi Mcingana, Ntambue Mulumba, Carly A. Comins, Lillian Shipp, Siyanda Makama, S. Wilson Beckham, Harry Hausler, Stefan D. Baral, Sheree R. Schwartz
Background: Given intersecting social and structural factors, female sex workers (FSW) exhibit elevated risk of HIV and substance use. However, there is limited study of how distinct substance use typologies influence HIV treatment outcomes among FSW. Setting: A cross-sectional survey with objective viral load assessments of 1,391 FSW enrolled into a treatment optimization-focused trial in Durban,
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“If it weren't for this, we'd be sick” - Perspectives from participants of a couple-based HIV treatment and support program during prenatal and postpartum periods in Zambézia Province, Mozambique J. Acquir. Immune Defic. Syndr. (IF 3.6) Pub Date : 2023-11-30 Hannah L. Brooks, Erin Graves, Caroline De Schacht, Almiro Emílio, Ariano Matino, Arifo Aboobacar, Carolyn M. Audet
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Early Initiation of Antiretroviral Therapy is Protective Against Seizures in Children with HIV in Zambia: A Prospective Case-Control Study J. Acquir. Immune Defic. Syndr. (IF 3.6) Pub Date : 2023-11-30 David R. Bearden, Sylvia Mwanza-Kabaghe, Christopher M. Bositis, Ifunanya Dallah, Brent A. Johnson, Omar K. Siddiqi, Melissa A. Elafros, Harris A. Gelbard, Jason F. Okulicz, Lisa Kalungwana, Nkhoma Musonda, William H. Theodore, Musaku Mwenechanya, Manoj Mathews, Izukanji T. Sikazwe, Gretchen L. Birbeck
Background: Seizures are relatively common among children with HIV in low-and middle-income countries, and are associated with significant morbidity and mortality. Early treatment with antiretroviral therapy may reduce this risk by decreasing rates of central nervous system infections and HIV encephalopathy. Methods: We conducted a prospective, unmatched case-control study. We enrolled children with
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Mortality Among Persons With HIV in the United States During the COVID-19 Pandemic: A Population-Level Analysis J. Acquir. Immune Defic. Syndr. (IF 3.6) Pub Date : 2023-11-21 Alex Viguerie, Ruiguang Song, Karin Bosh, Cynthia M. Lyles, Paul G. Farnham
Background: Whether the COVID-19 pandemic has had a disproportionate impact on mortality among persons with diagnosed HIV (PWDH) in the United States is unclear. Through our macroscale analysis, we seek to better understand how the COVID-19 pandemic affected mortality among PWDH. Methods: We obtained mortality and population data for the years 2018–2020 from the National HIV Surveillance System for
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Brief Report: HIV Pre-Exposure Prophylaxis Awareness and Use Among Adolescents in Kenya J. Acquir. Immune Defic. Syndr. (IF 3.6) Pub Date : 2023-11-21 Hong-Ha M. Truong, Elsa Heylen, Kevin Kadede, Sayo Amboka, Beatrice Otieno, Hanningtone Odhiambo, Damaris Odeny, Marion Hewa, Maurice Opiyo, Fidel Opondo, David Ogolla, Mary A. Guzé, Lara E. Miller, Elizabeth A. Bukusi, Craig R. Cohen
Background: HIV pre-exposure prophylaxis (PrEP) is an effective prevention tool; however, use among adolescents is thought to be low. To determine the unmet need and opportunity to expand use, we assessed awareness, prior use, and willingness to take PrEP among Kenyan adolescents. Methods: The Maneno Yetu study recruited a community-based sample of adolescents aged 15–19 years (N = 3061) in Kisumu
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Brief Report: Decreased Physical Activity and Prolonged Sitting Time Are Associated With Liver Steatosis in People With HIV J. Acquir. Immune Defic. Syndr. (IF 3.6) Pub Date : 2023-11-21 Carlotta Riebensahm, Annalisa Berzigotti, Bernard Surial, David Haerry, Huldrych F. Günthard, Philip E. Tarr, Hansjakob Furrer, Andri Rauch, Gilles Wandeler
Background: Physical activity (PA) regulates intrahepatic storage of fat and reduces the risk of liver steatosis. Given our limited understanding of the pathogenesis of metabolic complications in people with HIV (PWH), it remains unclear whether evidence from the general population can be extrapolated to PWH. We investigated the association between PA and liver steatosis in a single site of the Swiss
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Venous Thromboembolism Among People With HIV: Design, Implementation, and Findings of a Centralized Adjudication System in Clinical Care Sites Across the United States J. Acquir. Immune Defic. Syndr. (IF 3.6) Pub Date : 2023-11-21 Heidi M. Crane, Robin M Nance, Stephanie A. Ruderman, Lara Haidar, Mark W. Tenforde, Susan R. Heckbert, Matthew J. Budoff, Andrew W. Hahn, Lydia N. Drumright, Jimmy Ma, L. S. Mixson, William B. Lober, Gregory S. Barnes, Justin McReynolds, Engi F. Attia, Inga Peter, Tesfaye Moges, Laura Bamford, Edward Cachay, William C Mathews, Katerina Christopolous, Peter W. Hunt, Sonia Napravnik, Jeanne Keruly,
Background: People with HIV (PWH) are at increased risk for venous thromboembolism (VTE). We conducted this study to characterize VTE including provoking factors among PWH in the current treatment era. Methods: We included PWH with VTE between 2010 and 2020 at 6 sites in the CFAR Network of Integrated Clinical Systems cohort. We ascertained for possible VTE using diagnosis, VTE-related imaging, and
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HIV viral load patterns and risk factors among women in prevention of mother-to-child transmission (PMTCT) programs to inform differentiated service delivery (DSD) J. Acquir. Immune Defic. Syndr. (IF 3.6) Pub Date : 2023-11-18 Wenwen Jiang, Keshet Ronen, Lusi Osborn, Alison L. Drake, Jennifer A. Unger, Daniel Matemo, Barbra A. Richardson, John Kinuthia, Grace John-Stewart
Background: Differentiated service delivery (DSD) approaches decrease frequency of clinic visits for individuals who are stable on antiretroviral therapy (ART). It is unclear how to optimize DSD models for postpartum women living with HIV (PWLH). We evaluated longitudinal HIV viral load (VL) and cofactors, and modelled DSD eligibility with virologic failure (VF) among PWLH in PMTCT programs. Methods:
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Incidence and Management of Complex Kidney Situations Among On-demand and Daily HIV Pre-exposure Prophylaxis Users J. Acquir. Immune Defic. Syndr. (IF 3.6) Pub Date : 2023-11-18 Geoffroy LIEGEON, Alexandre BRUN, Gwenn HAMET, Jeremy ZEGGAGH, Claire PINTADO, Bénédicte LOZE, Diane PONSCARME, Willy ROZENBAUM, Jean Michel MOLINA
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Suicide Ideation and Attempt Among People With HIV: A Statewide Population-level Cohort Analysis Between 2005 and 2020 J. Acquir. Immune Defic. Syndr. (IF 3.6) Pub Date : 2023-11-18 Tianyue Mi, Jiajia Zhang, Xueying Yang, Shujie Chen, Sharon Weissman, Bankole Olatosi, Xiaoming Li
Background: Risk factors for suicidality among people with HIV (PWH) may evolve over their disease course, particularly as they develop comorbidities such as mental health disorders over time. Setting: This study compared the leading risk factors of suicide ideation/attempt among PWH in South Carolina across different combination antiretroviral therapy (cART) eras. Methods: A statewide cohort of PWH
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Facility HIV Self-Testing in Outpatient Departments: An Assessment of Characteristics and Concerns of Outpatients Who Opt Out of Testing in Malawi J. Acquir. Immune Defic. Syndr. (IF 3.6) Pub Date : 2023-11-18 Frackson Shaba, Kelvin T. Balakasi, Ogechukwu A. Offorjebe, Mike Nyirenda, Vincent J. Wong, Sundeep K. Gupta, Risa M. Hoffman, Kathryn Dovel
Background: Facility HIV self-testing (HIVST) in outpatient departments can dramatically increase testing among adult outpatients. However, it is still unclear why populations opt out of facility HIVST and reasons for opt outing. Using data from a parent facility HIVST trial, we sought to understand individual characteristics associated with opting out of facility HIVST and reported reasons for not
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The association of HIV control and immunosuppression with risk of non-AIDS defining cancer risk among patients on antiretroviral therapy J. Acquir. Immune Defic. Syndr. (IF 3.6) Pub Date : 2023-11-18 Brittney L. Dickey, Elizabeth L. Yanik, Zachary Thompson, Greer Burkholder, Mari M. Kitahata, Richard D. Moore, Jeff Jacobson, W. Christopher Mathews, Katerina A. Christopoulos, Julia Fleming, Sonia Napravnik, Chad Achenbach, Anna E. Coghill
Background PWH are experiencing an increased prevalence of non-AIDS defining cancers (NADCs). Our study investigated the association of immunosuppression and HIV control with NADCs among PWH on antiretroviral therapy (ART) in the US. Methods Among patients across 8 clinical cohorts on ART between 1996-2016 we assessed immune function and HIV control utilizing six metrics of CD4 count or HIV-RNA viral
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Factors Associated with Antiretroviral Adherence among Youth Living with HIV J. Acquir. Immune Defic. Syndr. (IF 3.6) Pub Date : 2023-11-18 Elizabeth Mayfield Arnold, Susan Kamal, Mary Jane Rotheram-Borus, S. Kate Bridges, William Gertsch, Peter Norwood, Dallas Swendeman
Background: Youth living with HIV (YLH) have an increased risk for psychosocial stressors that can impact their antiretroviral (ARV) adherence. We examined factors associated with self-reported ARV adherence among YLH ages 12-24 years old. Setting: YLH (N=147) were recruited in Los Angeles, California, and New Orleans, Louisiana from 2017-2020. Methods: YLH whose self-reported recent (30 days) ARV
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Longitudinal Assessment of Bone Mineral Density in Women Living With and Without HIV Across Reproductive Phases J. Acquir. Immune Defic. Syndr. (IF 3.6) Pub Date : 2023-11-14 Shayda A. Swann, Elizabeth M. King, Jerilynn C. Prior, Claudie Berger, Ulrike Mayer, Neora Pick, Amber R. Campbell, Hélène C. F. Côté, Melanie C. M. Murray
Background: Women living with HIV commonly experience low areal bone mineral density (BMD), but whether this is affected by low ovarian hormonal states (prolonged amenorrhea or menopause) is unknown. We compared rates of BMD loss between women living with HIV and HIV-negative control women and investigated its association with low ovarian hormonal states. Setting: Women living with HIV were enrolled
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Switching to Doravirine in cART-Experienced Patients: An Effective and Highly Tolerated Option With Substantial Cost Savings J. Acquir. Immune Defic. Syndr. (IF 3.6) Pub Date : 2023-11-14 Vincent R. Lanting, Piter Oosterhof, Daoud Ait Moha, Roos van Heerde, Marie José T. Kleene, Janneke E. Stalenhoef, Marieke J.A. de Regt, Saskia M.E. Vrouenraets, Guido E.L. van den Berk, Kees Brinkman
Background: Doravirine is a non-nucleoside reverse transcriptase inhibitor with demonstrated efficacy as a third agent in treatment-naive and treatment-experienced people living with HIV (PLWH) in registration studies. However, limited real-world data are available. Methods: By searching electronic health care records, PLWH using doravirine-based regimens were selected with at least 1 year of follow-up
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Pharmacokinetics, Safety, and Tolerability of Once-Daily Darunavir With Cobicistat and Weekly Isoniazid/Rifapentine J. Acquir. Immune Defic. Syndr. (IF 3.6) Pub Date : 2023-11-11 Kristina M. Brooks, Alice K. Pau, Doris Swaim, Haden T. Bunn, Lilian Adeojo, Charles A. Peloquin, Parag Kumar, Joseph A. Kovacs, Jomy M. George
Background: Once-weekly isoniazid with rifapentine (HP) for 3 months is a recommended treatment for latent tuberculosis infection in persons with HIV. HP reduces exposures of certain antiretroviral medications, resulting in limited options for the concomitant use of these therapies. Here, we examined the pharmacokinetics (PK), safety, and tolerability of darunavir/cobicistat with HP. Methods: This
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Cancer Treatment Decision-Making for People Living With HIV: Physician-Reported Barriers, Facilitators, and Recommendations J. Acquir. Immune Defic. Syndr. (IF 3.6) Pub Date : 2023-11-11 Ashley Khouri, Maya J. Stephens, Jeanette Young, Patrick Galyean, Brandon A. Knettel, Emily M. Cherenack, Susan Zickmund, Melissa H. Watt, John Bartlett, Kathryn I. Pollak, Peter A. Ubel, Angela Fagerlin, Gita Suneja
Background: Compared with the general cancer population, people living with HIV (PLWH) and cancer are less likely to receive treatment and have significantly elevated cancer-specific mortality for many common cancer types. Physician recommendations drive the cancer therapy that patients receive, yet there is limited information assessing how cancer treatment decisions are made for people living with
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HIV Care Continuum Among People Living With HIV and History of Arrest and Mental Health Diagnosis J. Acquir. Immune Defic. Syndr. (IF 3.6) Pub Date : 2023-11-11 Sarah E. Wiehe, Tammie L. Nelson, Matthew C. Aalsma, Marc B. Rosenman, Sami Gharbi, J. Dennis Fortenberry
Objective: Justice involvement and psychiatric comorbidities contribute to excess HIV morbidity, yet their interaction is poorly understood. We examined associations of this overlap with HIV outcomes among people living with HIV (PLWH). Methods: We conducted a retrospective cohort study of PLWH aged 13 years and older residing in Marion County (Indianapolis), IN, during 2018 (n = 5730) using linked
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A Machine Learning Approach to Predict Weight Change in ART-Experienced People Living With HIV J. Acquir. Immune Defic. Syndr. (IF 3.6) Pub Date : 2023-11-11 Federico Motta, Jovana Milic, Licia Gozzi, Michela Belli, Laura Sighinolfi, Gianluca Cuomo, Federica Carli, Giovanni Dolci, Vittorio Iadisernia, Giulia Burastero, Cristina Mussini, Paolo Missier, Federica Mandreoli, Giovanni Guaraldi
Introduction: The objective of the study was to develop machine learning (ML) models that predict the percentage weight change in each interval of time in antiretroviral therapy–experienced people living with HIV. Methods: This was an observational study that comprised consecutive people living with HIV attending Modena HIV Metabolic Clinic with at least 2 visits. Data were partitioned in an 80/20
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More Frequent HIV Viral Load Testing With Point-Of-Care Tests Detects Elevated Viral Load Earlier in Postpartum HIV-Positive Women in a Randomized Controlled Trial in Two Clinics in Johannesburg, South Africa J. Acquir. Immune Defic. Syndr. (IF 3.6) Pub Date : 2023-11-11 Lee Fairlie, Shobna Sawry, Sherri Pals, Gayle Sherman, Dhelia Williamson, Jean Le Roux, Bernadette Ngeno, Leigh Berrie, Karidia Diallo, Mackenzie Hurlston Cox, Mary Mogashoa, Matthew Chersich, Surbhi Modi
Background: Elevated maternal HIV viral load (VL) increases vertical transmission risk for breastfeeding children. This randomized controlled trial in Johannesburg primarily evaluated whether 3-monthly point-of-care testing, with laboratory-based standard-of-care testing (arm 2), compared with 6-monthly laboratory-based VL testing (arm 1) in postpartum women living with HIV receiving first-line te