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Immunohistochemical analysis of chronic and recurrent dermatophytosis Mycoses (IF 4.9) Pub Date : 2024-03-16 Ramesh M. Bhat, Monisha Madhumita, Nisha J. Marla, Jyothi Jayaraman
BackgroundDermatophytosis has assumed epidemic proportions with rising resistance, recalcitrance and recurrence, especially in tropical regions. While various factors contribute to high prevalence worldwide, yet little is known about the interactions between host defence mechanisms and dermatophytes, particularly in chronic and recalcitrant dermatophytosis.ObjectivesWe aimed to compare the population
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Responses of keratinocytes to Trichophyton mentagrophyte infection based on whole transcriptome analysis Mycoses (IF 4.9) Pub Date : 2024-03-14 Fangfang Zang, Zhangxu Wang, Yuanxue Yang, Ziyao Xiao, Zhaodan Wu, Jia Zhang, Bishibei Li, Jiayu Zheng, Xixi Zhu, Ying Wan, Ran Wang, Wudian Xiao
BackgroundDermatophytosis is an intractable superficial mycosis in humans and animals mainly caused by Trichophyton mentagrophytes (T. mentagrophytes), with a global prevalence of about 20%. Keratinocytes are the most abundant participants in skin immunity, and they also play a role in the first‐line defence against T. mentagrophytes. However, no studies of keratinocyte responses against T. mentagrophytes
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CARD9 mutations in patients with fungal infections: An update from the last 5 years Mycoses (IF 4.9) Pub Date : 2024-03-14 Maryanna da Silva Dantas, Maria Eduarda Carvalho Cintra, Fabíola Lucini, James Venturini, Gleyce Hellen de Almeida de Souza, Luana Rossato
BackgroundAutosomal recessive deficiency in the caspase recruitment domain‐containing protein 9 (CARD9) is a congenital immunological condition that leads to susceptibility to mucocutaneous and invasive fungal infections. There is growing incidence of fungal infections in patients with CARD9 deficiency, a phenomenon that is increasingly recognised.ObjectivesThis study aimed to assess the frequency
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Baseline chest computed tomography for diagnosis of invasive aspergillosis in patients with acute myeloid leukaemia treated with intensive chemotherapy: A retrospective single‐centre cohort study Mycoses (IF 4.9) Pub Date : 2024-03-13 Emilie Janssens, Sammy Huygens, Ine Moors, Anke Delie, Tessa Kerre, Yannick Vande Weygaerde, Eva Van Braeckel, Jerina Boelens, Lieve Morbée, Alexander Schauwvlieghe
BackgroundInvasive pulmonary aspergillosis (IPA) is a relatively common infection in patients with acute myeloid leukaemia (AML), and is associated with high mortality rates. Optimising early detection is key to reduce the burden of IPA in this population. In this retrospective cohort study, we evaluated the added value of baseline chest CT before start of classical induction chemotherapy.MethodsAdult
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Glucocorticoids as a risk factor for infection and adverse outcomes in non‐HIV and non‐transplant patients with cryptococcal meningitis Mycoses (IF 4.9) Pub Date : 2024-03-02 Luke Kim, Carolina Ferraz, Michaele Francesco Corbisiero, Sarah Gorvetzian, Carlos Franco‐Paredes, Martin Krsak, Leland Shapiro, George R. Thompson, Daniel B. Chastain, Jose Tuells, Andrés F. Henao‐Martínez
BackgroundCryptococcal meningitis (CM), an opportunistic fungal infection affecting immunocompromised hosts, leads to high mortality. The role of previous exposure to glucocorticoids as a risk factor and as an outcome modulator has been observed, but systematic studies are lacking.ObjectiveThe primary aim of this study is to evaluate the impact of glucocorticoid use on the clinical outcomes, specifically
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Pan‐azole‐resistant Meyerozyma guilliermondii clonal isolates harbouring a double F126L and L505F mutation in Erg11 Mycoses (IF 4.9) Pub Date : 2024-03-02 Jérémy Moreau, Thierry Noël, Kévin Point, Frédéric Tewes, Luc Deroche, Jonathan Clarhaut, Valérie Fitton‐Ouhabi, Estelle Perraud, Sandrine Marchand, Julien M. Buyck, Kévin Brunet
BackgroundMeyerozyma guilliermondii is a yeast species responsible for invasive fungal infections. It has high minimum inhibitory concentrations (MICs) to echinocandins, the first‐line treatment of candidemia. In this context, azole antifungal agents are frequently used. However, in recent years, a number of azole‐resistant strains have been described. Their mechanisms of resistance are currently poorly
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Incidence and prevalence of chronic pulmonary aspergillosis in patients with post‐tuberculosis lung abnormality: Results from a community survey in North India Mycoses (IF 4.9) Pub Date : 2024-02-28 Kathirvel Soundappan, Inderpaul Singh Sehgal, Nidhi Prabhakar, Samriti Rana, Rajesh Raju, Sahajal Dhooria, Kuruswamy Thurai Prasad, Valliappan Muthu, Shivaprakash M. Rudramurthy, Arunaloke Chakrabarti, Mandeep Garg, Ritesh Agarwal
BackgroundPost‐tuberculosis lung abnormality (PTLA) is the most common risk factor for developing chronic pulmonary aspergillosis (CPA). However, the prevalence and incidence of CPA in PTLA patients in India remain unknown.ObjectivesWe aimed to ascertain the incidence and prevalence of CPA in subjects with PTLA.MethodsWe identified a cohort of pulmonary tuberculosis who completed anti‐tuberculosis
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Activity of amorolfine or ciclopirox in combination with terbinafine against pathogenic fungi in onychomycosis—Results of an in vitro investigation Mycoses (IF 4.9) Pub Date : 2024-02-28 Martin Schaller, Birgit Walker, Schafiq Nabhani, Astrid Odon, Simon Riel, Andreas Jäckel
BackgroundOnychomycoses are difficult‐to‐treat fungal infections with high relapse rates. Combining oral and topical antifungal drugs is associated with higher success rates. Additive or synergistic modes of action are expected to enhance treatment success rates.ObjectivesInvestigation of the combined effects of antifungal drugs in vitro with different modes of action and application on clinical isolates
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Terbinafine resistance in Trichophyton mentagrophytes and Trichophyton rubrum in the Czech Republic: A prospective multicentric study Mycoses (IF 4.9) Pub Date : 2024-02-26 Daniela Kolarczyková, Pavlína Lysková, Michaela Švarcová, Ivana Kuklová, Radim Dobiáš, Naďa Mallátová, Miroslav Kolařík, Vit Hubka
BackgroundTerbinafine, an allylamine antifungal, is crucial for treating dermatophytosis by inhibiting squalene epoxidase (SQLE) in the ergosterol biosynthetic pathway. However, resistance is emerging, particularly in India and Southeast Asia, but reports of resistance spread worldwide. Despite this, comprehensive studies on terbinafine resistance in Trichophyton are still limited.ObjectivesThis research
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Clinical characteristics, diagnosis, and treatment of central nervous system sporotrichosis: Systematic review and meta‐analysis Mycoses (IF 4.9) Pub Date : 2024-02-20 Vítor Falcão de Oliveira, Júlia Figueiredo Petrucci, Mariane Taborda, Pedro Zanetta Brener, Pedro Guilherme De Barros Brito Kremer, Bruno Azevedo Randi, Adriana Satie Gonçalves Kono Magri, Marcello Mihailenko Chaves Magri, Anna S. Levin, Guilherme Diogo Silva
BackgroundThe clinical features of central nervous system (CNS) sporotrichosis are derived from case reports and a limited series of cases. Our objective was to carry out a systematic review and meta‐analysis of CNS sporotrichosis.MethodsWe searched PubMed/MEDLINE, Embase, Scopus, and LILACS on 9 September 2023. Our inclusion criteria were documentation of Sporothrix and demonstrated CNS involvement
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Sensitivity and specificity of LDBioAspergillusICT lateral flow assay for diagnosing allergic bronchopulmonary aspergillosis in adult asthmatics Mycoses (IF 4.9) Pub Date : 2024-02-19 Inderpaul Singh Sehgal, Valliappan Muthu, Sahajal Dhooria, Kuruswamy Thurai Prasad, Shivaprakash M. Rudramurthy, Ashutosh Nath Aggarwal, Mandeep Garg, Jean‐Pierre Gangneux, Arunaloke Chakrabarti, Ritesh Agarwal
BackgroundAspergillus fumigatus‐specific IgG estimation is crucial for diagnosing allergic bronchopulmonary aspergillosis (ABPA). A point‐of‐care LDBio immunochromatographic lateral flow assay (LFA) had 0%–90% sensitivity to detect IgG/IgM antibodies against A. fumigatus.ObjectiveTo assess the accuracy of LDBio‐LFA in diagnosing ABPA, using the modified ISHAM‐ABPA working group criteria as the reference
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High attenuation mucus in bronchi with allergic bronchopulmonary mycosis Mycoses (IF 4.9) Pub Date : 2024-02-18 Shigeaki Hattori, Tsuyoshi Oguma, Takashi Ishiguro, Junko Suzuki, Koichi Fukunaga, Terufumi Shimoda, Hirokazu Kimura, Yasushi Obase, Naoki Okada, Jun Tanaka, Asako Kitahara, Katsuyoshi Tomomatsu, Yoshiki Shiraishi, Koichiro Asano
High-attenuation mucus (HAM) is a specific manifestation of allergic bronchopulmonary mycosis (ABPM) on chest computed tomography (CT).
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Identification of primary metabolites in fungal species of Trichophyton mentagrophyte and Trichophyton rubrum by NMR spectroscopy Mycoses (IF 4.9) Pub Date : 2024-02-16 Rashmi Parihar, Upendra Singh, Anupam Das, Bikash Baishya, Vikramjeet Singh, S.C. Ahirwar, Sana Islahi, Manodeep Sen, Vineeta Mittal
Superficial mycoses are fungal infections limited to the outermost layers of the skin and its appendages. The chief causative agents of these mycoses are dermatophytes and yeasts. The diagnosis of dermatophytosis can be made by direct mycological examination with potassium hydroxide (10%–30%) of biological material obtained from patients with suspected mycosis, providing results more rapid than fungal
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A clinical prevalence of dermatophytic mycoses with an assessment of its clinical manifestations in a tertiary care hospital at Salem, South India Mycoses (IF 4.9) Pub Date : 2024-02-16 Arul Balasubramanian, Nazer Ali Akbar Ali, Atchaya Pugazhenthi, Kannan Gopalan, Silambarasan Tamil Selvan, Kothai Ramalingam
Dermatophytosis is very common among all age groups throughout the world. The incidence of the same is increasing on a steady basis.
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Usefulness of 18F-FDG PET-CT for the management of invasive fungal infections: A retrospective cohort from a tertiary university hospital Mycoses (IF 4.9) Pub Date : 2024-02-07 Isabel Gutiérrez-Martín, Sonia García-Prieto, Karina Velásquez, Edith Vanessa Gutiérrez-Abreu, Itziar Diego-Yagüe, Jorge Calderón-Parra, Andrea Gutiérrez-Villanueva, Antonio Ramos-Martínez, Elena Múñez-Rubio, Alejandro Callejas-Díaz, Sara De la Fuente Moral, Alberto Díaz de Santiago, Isabel Sánchez Romero, Begoña Rodríguez Alfonso, Ana Fernández-Cruz
18F-FDG PET-CT is a potentially useful technique to help manage invasive fungal infection (IFI), but information on this topic is scarce.
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Prevalence and characteristics of Epidermophyton floccosum skin infections: A 12-year retrospective study Mycoses (IF 4.9) Pub Date : 2024-02-07 Ya-Nin Nokdhes, Charussri Leeyaphan, Pattriya Jirawattanadon, Bawonpak Pongkittilar, Chudapa Sereeaphinan, Sumanas Bunyaratavej
Epidermophyton floccosum (E. floccosum), an anthropophilic dermatophyte, is the primary causative agent of skin conditions such as tinea cruris, tinea pedis and tinea corporis.
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A systematic review and disability-adjusted life years of Scedosporium/Lomentospora infection in patients after near-drowning Mycoses (IF 4.9) Pub Date : 2024-02-12 Firoozeh Kermani, Jamshid Yazdani Charati, Behrad Roohi, Azam Moslemi, Azadeh Bandeghani, Leila Faeli, Tahereh Shokohi, Emmanuel Roilides
Scedosporium/Lomentospora species exist as saprophytic moulds that can potentially lead to serious infections in patients who have experienced near-drowning incidents. Scedosporium species are distributed across different regions of the world while Lomentospora prolificans has quite a restricted geographic distribution. We aimed to systematically review scedosporiosis cases after near-drowning, their
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Diagnostic values of ten methods in patients with onychomycosis: A network meta-analysis Mycoses (IF 4.9) Pub Date : 2024-02-04 Yan Zhao, Xinwei Wang, Changyu Lu
Onychomycosis, a disease was with a high global prevalence, has been the focal point of this study. The research aims to compare diagnostic efficacy among various methods, including potassium hydroxide (KOH), Dimethyl sulfoxide (DMSO), specific colour staining (Chlorazol, lactophenol cotton blue and Chicago sky blue stain), fluorescent staining (calcofluor white stain, acridine orange fluorescent dye)
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Aetiology of tinea of vellus hair and substrate specificity in Microsporum species Mycoses (IF 4.9) Pub Date : 2024-01-30 Xin Zhou, Wentao Liu, Meirong Li, Rong Wu, Angela Wu, Peiran Chen, Shitong Qin, Huanting Li, Ling Wei, Guoxing Zhu, Sybren de Hoog, Peiying Feng
Tinea of vellus hair is a dermatophyte infection with or without localised infection of adjacent skin. The epidemiology and pathogenesis of this disorder have insufficiently been established.
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Skin innate immune response against fungal infections and the potential role of trained immunity Mycoses (IF 4.9) Pub Date : 2024-01-21 Amanda Bombassaro, Julia Marcondes Figueiredo, Carlos P. Taborda, Leo A. B. Joosten, Vania A. Vicente, Flavio Queiroz-Telles, Jacques F. Meis, Brenda Kischkel
Fungal skin infections are distributed worldwide and can be associated with economic and social traits. The immune response related to skin cells is complex and its understanding is essential to the comprehension of each cell's role and the discovery of treatment alternatives. The first studies of trained immunity (TI) described the ability of monocytes, macrophages and natural killer (NK) cells to
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Clonal spread of fluconazole-resistant C. parapsilosis in patients admitted to a referral hospital located in Burgos, Spain, during the COVID-19 pandemic Mycoses (IF 4.9) Pub Date : 2024-01-18 María de los Ángeles Mantecón-Vallejo, Aina Mesquida, María de Valle Ortiz, Luis Buzón-Martín, Sergio Ossa-Echeverri, Lourdes Fisac-Cuadrado, Gregoria Megías-Lobón, María Pilar Ortega-Lafont, Patricia Muñoz, Pilar Escribano, Jesús Guinea
Fluconazole-resistant Candida parapsilosis (FRCP) is a matter of concern in Spain.
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Clinical characteristics, bacterial coinfections and outcomes in COVID-19-associated pulmonary aspergillosis in a third-level Mexican hospital during the COVID-19 pre-vaccination era Mycoses (IF 4.9) Pub Date : 2024-01-07 Graciela Hernández-Silva, Dora E. Corzo-León, Eduardo Becerril-Vargas, Amy Bethel Peralta-Prado, Rodríguez-Ganes Odalis, Fernando Morales-Villarreal, Martin Armando Ríos-Ayala, Tortoriello-Garza Alonso, Fernández-López David Agustín, Avilez-Félix Ramón, Ahumada-Topete Víctor Hugo
Damage due to respiratory viruses increases the risk of bacterial and fungal coinfections and superinfections. High rates of invasive aspergillosis are seen in severe influenza and COVID-19. This report describes CAPA cases diagnosed during the first wave in the biggest reference centre for severe COVID-19 in Mexico.
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Treatment of onychomycosis in an era of antifungal resistance: Role for antifungal stewardship and topical antifungal agents Mycoses (IF 4.9) Pub Date : 2024-01-03 Aditya K. Gupta, Boni Elewski, Warren S. Joseph, Shari R. Lipner, C. Ralph Daniel, Antonella Tosti, Eric Guenin, Mahmoud Ghannoum
A growing body of literature has marked the emergence and spread of antifungal resistance among species of Trichophyton, the most prevalent cause of toenail and fingernail onychomycosis in the United States and Europe. We review published data on rates of oral antifungal resistance among Trichophyton species; causes of antifungal resistance and methods to counteract it; and in vitro data on the role
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Supervised training models with or without manual lesion delineation outperform clinicians in distinguishing pulmonary cryptococcosis from lung adenocarcinoma on chest CT Mycoses (IF 4.9) Pub Date : 2024-01-03 Yun Li, Deyan Chen, Shuyi Liu, Junfeng Lin, Wei Wang, Jinhai Huang, Lunfang Tan, Lina Liang, Zhufeng Wang, Kang Peng, Qiasheng Li, Wenhua Jian, Youwen Zhang, Chengbao Peng, Huai Chen, Xia Zhang, Jinping Zheng
The role of artificial intelligence (AI) in the discrimination between pulmonary cryptococcosis (PC) and lung adenocarcinoma (LA) warrants further research.
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Understanding clinical outcomes and factors influencing mortality in intensive care unit patients with COVID-19-associated candidemia Mycoses (IF 4.9) Pub Date : 2024-01-03 Selda Aydın, Ali Mert, Mesut Yılmaz, Muna Al Maslamani, Bilal Ahmad Rahimi, Folusakin Ayoade, Amani El-Kholy, Maya Belitova, Buket Erturk Sengel, Sabah Jalal, Ayşe Albayrak, Jamayel Adnan Alatawi, Balint Gergely Szabo, Ramesh Shankar Ganeshan, Emmanuel Nsutebu, Aruna Poojary, Yasemin Akkoyunlu, Sevil Alkan, Dilşah Başkol Elik, Gulden Eser-Karlidag, Lurdes Santos, Ruxandra Moroti, Nilgün Altın, Esra
During the COVID pandemic, research has shown an increase in candidemia cases following severe COVID infection and the identification of risk factors associated with candidemia. However, there is a lack of studies that specifically explore clinical outcomes and mortality rates related to candidemia after COVID infection.
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Inter-observer reliability of the Onychomycosis Severity Index depending on clinical experience: A review of 50 cases Mycoses (IF 4.9) Pub Date : 2024-01-04 David Navarro-Pérez, Sara García-Oreja, Aroa Tardáguila-García, Diego León-Herce, Francisco Javier Álvaro-Afonso, José Luis Lázaro-Martínez
Onychomycosis (ONM) is the most prevalent nail unit pathology, and its severity and monitoring are often based on the visual judgement of clinicians.
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Screening Candida auris through a multiplex stepwise PCR algorithm directly from clinical samples of patients suspected of otomycosis in south of Iran; Detection of five cases Mycoses (IF 4.9) Pub Date : 2024-01-01 Behrouz Naeimi, Fatemeh Safari, Kazem Ahmadikia, Mohammad Javad Ahmadipour, Farzaneh Sadeghzadeh, Nahid Kondori, Bahram Ahmadi
Otomycosis is an infection of the external auditory canal caused by molds and yeasts with descending frequency. Laboratory diagnosis is usually confirmed by microscopy and culture. However, they are not specific enough to reliably differentiate the causative agents, especially for rare pathogens such as Candida auris. The purpose of the current study was to the molecular screening of C. auris species
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Clinical characteristics and risk factors for late-onset pneumocystis jirovecii pneumonia in kidney transplantation recipients Mycoses (IF 4.9) Pub Date : 2024-01-01 Xiaofeng Zhu, Mengshu Xie, Jiaqi Fan, Bei Geng, Guangru Fei, Qianqian Zhou, Huimei Wu, Xuehan Liu, Xuqin Jiang
Pneumocystis jirovecii pneumonia (PJP) is a common and troublesome complication of kidney transplantation. In the era of prophylaxis, the peak incidence of PJP after kidney transplantation and specific characteristics of late-onset PJP have always been debated.
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Temporal trends in antifungal susceptibility of Cryptococcus neoformans isolates from a reference laboratory in the United States, 2011–2021 Mycoses (IF 4.9) Pub Date : 2024-01-02 Eloy E. Ordaya, Omar M. Abu Saleh, Paschalis Vergidis, Sharon M. Deml, Nancy L. Wengenack, Madiha Fida
There are no established clinical breakpoints for antifungal agents against Cryptococcus species; however, epidemiological cut-off values can help distinguish wild-type (WT) isolates without any acquired resistance from non-WT strains, which may harbour resistance mechanisms.
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Efficacy of topical trichloroacetic acid 100% either alone or combined with topical tioconazole 28% versus systemic itraconazole in the treatment of onychomycosis Mycoses (IF 4.9) Pub Date : 2024-01-01 Al-shimaa M. Ibrahim, Nermeen Sabry Ibrahim, Eman S. Elgharabawy, Hala Mohamed Morsi
Treatment of onychomycosis is still challenging and warrants the development of new treatment strategies. Different trials were conducted to increase the penetration and efficacy of topical antifungals aiming at finding an alternative treatment especially when systemic antifungals are contraindicated.
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Incidence of invasive fungal diseases in inflammatory bowel disease patients: A nationwide study in South Korea Mycoses (IF 4.9) Pub Date : 2024-01-01 Ji Eun Na, Sung Hoon Jung, Arum Choi, Sukil Kim, Tae-Oh Kim
Limited reports exist regarding invasive fungal diseases (IFDs) in inflammatory bowel disease (IBD) patients.
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Efficacy of biofilm disrupters against Candida auris and other Candida species in monomicrobial and polymicrobial biofilms Mycoses (IF 4.9) Pub Date : 2023-12-21 Claudia A. Cox, Elias K. Manavathu, Sushama Wakade, Matthew Myntti, Jose A. Vazquez
Candida species are now considered global threats by the CDC and WHO. Candida auris specifically is on the critical pathogen threat list along with Candida albicans. In addition, it is not uncommon to find Candida spp. in a mixed culture with bacterial organisms, especially Staphylococcus aureus producing polymicrobial infections. To eradicate these organisms from the environment and from patient surfaces
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Evaluation of the benefit of the addition of 1% topical luliconazole versus topical bland emollient to the systemic itraconazole therapy for the management of disseminated dermatophytosis: A randomised control trial Mycoses (IF 4.9) Pub Date : 2023-12-14 Deval K. Rana, Tithi S. Shah, Mansi H. Rohit, Nayankumar H. Patel, Avinash D. Khadela, Yaksh P. Oza, Jigna K. Padhiyar
The present epidemic of dermatophytosis in India is marked by an increase in chronic, recurrent and disseminated cases. A combination of oral itraconazole and topical luliconazole is being increasingly utilised by dermatologists in India. The superiority of this combination is not supported by robust clinical trial data.
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Comparing the diagnostic accuracy of PCR-reverse blot hybridization assay and conventional fungus study in superficial fungal infection of the skin: A systematic review Mycoses (IF 4.9) Pub Date : 2023-12-08 Jae Joon Jeon, You Hyun Kim, Sung Ha Lim, Solam Lee, Eung Ho Choi
In superficial fungal infections, prompt diagnosis and treatment are essential to prevent the spread of infection and minimise the impact on patients' quality of life. Traditional diagnostic methods, such as KOH smear and fungal culture, have limitations in terms of sensitivity and turnaround time. Recently, the PCR-reverse blot hybridization assay (PCR-REBA) has been developed for the direct detection
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Immune and metabolic perturbations in COVID-19-associated pulmonary mucormycosis: A transcriptome analysis of innate immune cells Mycoses (IF 4.9) Pub Date : 2023-12-08 Manpreet Dhaliwal, Valliappan Muthu, Arunima Sharma, Khem Raj, Shivaprakash M Rudramurthy, Ritesh Agarwal, Harsimran Kaur, Amit Rawat, Surjit Singh, Arunaloke Chakrabarti
The mechanisms underlying COVID-19-associated pulmonary mucormycosis (CAPM) remain unclear. We use a transcriptomic analysis of the innate immune cells to investigate the host immune and metabolic response pathways in patients with CAPM.
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NLRP3 regulates CIITA/MHC II axis and interferon-γ-inducible chemokines in Malassezia globosa-infected keratinocytes Mycoses (IF 4.9) Pub Date : 2023-12-08 Yun Luo, Jin-Feng Tang, Fei-Fei Gao, Juan-Hua Quan, Chuan-Ting Ma, Shi-Jie Li, Yi-Ming Fan
CIITA, a member of NOD-like receptor (NLR) family, is the major MHC II trans-activator and mediator of Th1 immunity, but its function and interaction with NLRP3 have been little studied. We found activation of NLRP3 inflammasome, increased expression of CIITA, CBP, pSTAT1, STAT1, MHC II, IFN-γ and IFN-γ-inducible chemokines (CCL1 and CXCL8), and colocalisation of NLRP3 with CIITA in Malassezia folliculitis
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Fluconazole-resistant Candida parapsilosis complex candidemia and analysis of mutations in the ERG11 gene from Pakistan Mycoses (IF 4.9) Pub Date : 2023-11-21 Mohammad Zeeshan, Saba Memon, Ayesha Malick, Syed Faheem Naqvi, Joveria Farooqi, Najia Karim Ghanchi, Kauser Jabeen
Recent reports of the emergence of fluconazole resistance in Candida parapsilosis species complex poses a challenge, more specifically in settings where echinocandin-based treatment regime is not feasible.
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Invasive fungal infection incidence and risk factors in patients receiving ibrutinib in real-life settings: A nationwide population-based cohort study Mycoses (IF 4.9) Pub Date : 2023-11-20 Marion Allouchery, Kévin Brunet, Cécile Tomowiak, Allison Singier, Elodie Pambrun, Antoine Pariente, Julien Bezin, Marie-Christine Pérault-Pochat, Francesco Salvo
Data on the risk of invasive fungal infections (IFI) with ibrutinib treatment are scarce.
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Voriconazole plus flucytosine is not superior to amphotericin B deoxycholate plus flucytosine as an induction regimen for cryptococcal meningitis treatment Mycoses (IF 4.9) Pub Date : 2023-11-20 Handan Zhao, Yanqiu Lu, Shan Li, Jiangying Qin, Miaomiao Xu, Hui Ye, Zongxing Yang, Jianfeng Rao, Guochun Chen, Feifei Su, Zhiliang Hu, Lijun Xu
The efficacy and side effects of voriconazole plus 5-flucytosine (Vori + 5-FC) versus amphotericin B deoxycholate plus 5-flucytosine (AmBd + 5-FC) as an induction treatment for cryptococcal meningitis are unknown.
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Kerion Celsi in infants and children—A narrative review 2010–2023 Mycoses (IF 4.9) Pub Date : 2023-11-20 Anca Chiriac, Adriana Diaconeasa, Cristiana Voicu, Mihaela Ivaniciuc, Raluca Miulescu, Anca E. Chiriac, Pietro Nenoff, Uwe Wollina
Kerion Celsi is an inflammatory, deep fungal infection of the scalp. It is rare in neonates but gets more common in children about 3 years and older. It represents with swelling, boggy lesions, pain, alopecia and purulent secretions. Secondary bacterial infection is not unusual after maceration. Extracutaneous manifestations include regional lymphadenopathy, fever and very rare fungemia. Id-reactions
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Onychoscopic characteristics of Trichophyton rubrum and Trichophyton interdigitalis fungal infections: A multicentric study Mycoses (IF 4.9) Pub Date : 2023-11-15 Michela Starace, Elisa Milan, Giovanni Summa, Aurora Maria Alessandrini, Andrea Sechi, Matilde Iorizzo, Nilton Gioia Di Chiacchio, Nilton Di Chiacchio, Bianca Maria Piraccini
Trichophyton rubrum and Trichophyton mentagrophytes variant interdigitalis are the most frequent etiologic agents of onychomycosis. Diagnosis of certainty requires mycological examination, which often results unfeasible.
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Natural history and prognostic factors of candidemia in kidney transplant recipients: A retrospective, multinational study Mycoses (IF 4.9) Pub Date : 2023-11-09 Paula M. Peçanha-Pietrobom, Vanessa S. S. Truda, Mario Fernández-Ruiz, Manuel García Gutiérrez, Teresa Cristina T. Sukiennik, Daniel Wagner De C. L. Santos, Maricela Valerio, Francesca Gioia, Isabel Rodríguez-Goncer, Daniele Roberto Giacobbe, Antonio Vena, Marina Machado, Matteo Bassetti, Patricia Muñoz, José María Aguado, Helio Tedesco-Silva, Arnaldo Lopes Colombo
The natural history of candidemia in kidney transplant recipients (KTR) remains poorly understood. This study aimed to evaluate mortality, prognostic factors and overall graft loss after candidemia in KTRs.
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Molecular typing of a collection of Iranian clinical Trichophyton tonsurans isolates based on the non-transcribed spacer region of rDNA and antifungal susceptibility testing of the species Mycoses (IF 4.9) Pub Date : 2023-11-08 Leila Faeli, Firoozeh Kermani, Ali Rezaei-Matehkolaei, Macit Ilkit, Reza Valadan, Seyed Abdollah Hosseini, Javad Javidnia, Sabah Mayahi, Tahereh Shokohi, Mahdi Abastabar
Wrestling, considered the national sport of Iran, has gained immense popularity among Iranians. Wrestlers frequently encounter skin conditions, with dermatophyte fungal infections, particularly tinea gladiatorum (TG), being a common issue. TG, caused by the Trichophyton genus, has emerged as a major health concern for wrestlers and other contact sport athletes worldwide. This study aimed to assess
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Application of machine learning for mortality prediction in patients with candidemia: Feasibility verification and comparison with clinical severity scores Mycoses (IF 4.9) Pub Date : 2023-11-01 Wei-Huan Hu, Shang-Yi Lin, Yuh-Jyh Hu, Ho-Yin Huang, Po-Liang Lu
Clinical severity scores, such as acute physiology, age, chronic health evaluation II (APACHE II), sequential organ failure assessment (SOFA), Pitt Bacteremia Score (PBS), and European Confederation of Medical Mycology Quality (EQUAL) score, may not reliably predict candidemia prognosis owing to their prespecified scorings that can limit their adaptability and applicability.
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Review Article White Piedra: Review of 131 cases Mycoses (IF 4.9) Pub Date : 2023-10-31 Ana Elena Guerrero-Ponce, Javier Araiza, Andrés Tirado-Sánchez, Alexandro Bonifaz
This study analyzes the clinical characteristics of patients diagnosed with White Piedra through a systematic review of cases in the literature. A sample of 131 subjects was considered, of which 91.6% were female and most were 18 years of age or younger. Most studies were conducted in Brazil, followed by India, and Mexico. The most common etiologic agent found was Trichosporon spp (34.3%). Most affected
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Questioning the 14-day dogma in candidemia treatment duration Mycoses (IF 4.9) Pub Date : 2023-10-27 Jon Salmanton-García, Ilana Reinhold, Juergen Prattes, Nico Bekaan, Philipp Koehler, Oliver A. Cornely
The growing threat of antimicrobial resistance (AMR) is a global concern. With AMR directly causing 1.27 million deaths in 2019 and projections of up to 10 million annual deaths by 2050, optimising infectious disease treatments is imperative. Prudent antimicrobial use, including treatment duration, can mitigate AMR emergence. This is particularly critical in candidemia, a severe condition with a 45%
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Histoplasma antigen detection in unconfirmed pulmonary tuberculosis and cross-reactivity with Aspergillus antigen in patients and in food in Jakarta, Indonesia Mycoses (IF 4.9) Pub Date : 2023-10-27 Meiliyana Wijaya, Sem Samuel Surja, Robiatul Adawiyah, Ariananda Hariadi, Findra Setianingrum, Anna Rozaliyani, Erlina Burhan, Mulyati Tugiran, Ridhawati Sjam, David W. Denning, Retno Wahyuningsih
H. capsulatum is endemic in Indonesia, but the value of Histoplasma antigen detection has not been studied.
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Hyperthermia is a promising potential adjunct to treating sporotrichosis: A refractory case of HIV sporotrichosis and in vitro experiments on Sporothrix spp. Mycoses (IF 4.9) Pub Date : 2023-10-27 Yuan-yuan Liu, Yang Song, Meng-qi Guan, Li Yang, Rui-li Chen, Ying Shi, Yan Cui, Shan-Shan Li
Hyperthermia is a common monotherapy for sporotrichosis, but only in patients with special conditions, such as pregnancy and nursing. However, hyperthermia has not been used more widely for sporotrichosis in clinical practice.
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Prior selection of itraconazole in the treatment of recalcitrant Trichophyton indotineae infection: Real-world results from retrospective analysis Mycoses (IF 4.9) Pub Date : 2023-10-26 Ge Song, Xue Kong, Xiaofang Li, Weida Liu, Guanzhao Liang
The number of terbinafine-resistant Trichophyton indotineae is increasing in recent years while the treatment is still a matter to discuss.
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Using (1,3)-β-D-glucan concentrations in serum to monitor the response of azole therapy in patients with eumycetoma caused by Madurella mycetomatis Mycoses (IF 4.9) Pub Date : 2023-10-23 Bertrand Nyuykonge, Emmanuel E. Siddig, Borna A. Nyaoke, Eduard E. Zijlstra, Annelies Verbon, Sahar M. Bakhiet, Ahmed H. Fahal, Wendy W. J. van de Sande
(1,3)-β-D-glucan is a panfungal biomarker secreted by many fungi, including Madurella mycetomatis, the main causative agent of eumycetoma. Previously we demonstrated that (1,3)-β-D-glucan was present in serum of patients with eumycetoma. However, the use of (1,3)-β-D-glucan to monitor treatment responses in patients with eumycetoma has not been evaluated.
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Nd:YAG 1064 nm laser treatment for onychomycosis - is it really effective? A prospective assessment for efficiency and factors contributing to response Mycoses (IF 4.9) Pub Date : 2023-10-20 Batheesh Ramzy, Avitan-Hersh Emily, Badi Jiryis, Khamaysi Ziad
Onychomycosis is a highly prevalent and persistent nail disorder primarily caused by dermatophytes. The effectiveness of current topical and systemic antifungals is limited by the extent and severity of the infection, patient demographics and health status, hepatic toxicity, drug interactions and low compliance. Laser therapy is a promising modality for safe and cost-effective removal of mycotic nail
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Evaluation of Eazyplex® LAMP test for fast Candida auris direct detection of colonized patients Mycoses (IF 4.9) Pub Date : 2023-10-20 Francisco Javier Hernández Felices, Nuria Tormo Palop, Carme Salvador García, Juan Vicente Mulet Bayona, M. Remedio Guna Serrano, Concepción Gimeno Cardona
Candida auris is a multidrug-resistant pathogen yeast that produces nosocomial outbreaks, due to its ability in colonizing the skin, mucous membranes and surfaces. Rapid diagnosis is essential to control its spread. The aim of this study was to compare the Eazyplex® Candida auris kit (AmplexDiagnostics GmbH) for the rapid identification of patients colonized with C. auris, with the reference method
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Medium-term antifungal effects of methylene blue versus flavin mononucleotide in the treatment of moderate toenail onychomycosis Mycoses (IF 4.9) Pub Date : 2023-10-15 Clara Gómez, Georg Schuele, Enrique Alberdi
Methylene blue (MB) and flavin mononucleotide (FMN)-mediated photodynamic therapy (PDT) have demonstrated local antimicrobial effect, but no direct comparative study has been published so far for the treatment of toenail onychomycosis.
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Retrospective analysis of onychomycosis prescribing patterns using the medicare part D prescribers database 2016–2020 Mycoses (IF 4.9) Pub Date : 2023-10-15 Katie Roster, Yu Wang, Shari R. Lipner
Onychomycosis, defined as a fungal nail infection, affects 5.5% of the global population. Our objectives were to analyse prescription trends of onychomycosis medications using the Medicare Part D Prescribers database from 2016 to 2020, stratified by physician specialty. There was a 4% annual increase in the total cost of onychomycosis medications, with a notable decrease of 12.8% in 2020 during the
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Comparing emollient use with topical luliconazole (azole) in the maintenance of remission of chronic and recurrent dermatophytosis. An open-label, randomized prospective active-controlled non-inferiority study Mycoses (IF 4.9) Pub Date : 2023-10-13 Yashdeep Singh Pathania, Katoch CDS, Ashok Kumar
Literature on emollient use in the management of chronic and recurrent dermatophytosis is limited.
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Contribution to the study of inflammasome and programmed cell death in paracoccidioidomycosis oral lesions Mycoses (IF 4.9) Pub Date : 2023-10-13 Carla Pagliari, Luciane Kanashiro-Galo, Mirian Nacagami Sotto
Paracoccidioidomycosis is the most prevalent systemic mycosis in Latin America, with a high incidence in Brazil, Colombia and Venezuela, and constitutes a serious public health problem, a frequent cause of morbidity and disability for work. Some mechanisms of cell death are described as important tools in infectious processes. When apoptosis is blocked, RIPK (Receptor-interacting protein kinase) 3
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The prognostic factors for cryptococcal meningitis in non-human immunodeficiency virus patients: An observational study using nationwide database Mycoses (IF 4.9) Pub Date : 2023-10-08 Hotaka Namie, Takahiro Takazono, Yusuke Hidaka, Shimpei Morimoto, Yuya Ito, Nana Nakada, Nobuyuki Ashizawa, Tatsuro Hirayama, Kazuaki Takeda, Naoki Iwanaga, Masato Tashiro, Naoki Hosogaya, Takeshi Tanaka, Kiyohide Fushimi, Katsunori Yanagihara, Hiroshi Mukae, Koichi Izumikawa
Cryptococcal meningitis (CM) is an invasive fungal infection with a poor prognosis that often occurs in both healthy individuals and compromised hosts, such as patients infected with human immunodeficiency virus (HIV). Unlike CM in HIV patients, evidence regarding CM in non-HIV patients is limited to small retrospective studies.
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New and emerging options for management of invasive fungal diseases in paediatric patients Mycoses (IF 4.9) Pub Date : 2023-10-04 Andreas H. Groll, Katharina Körholz, Malcolm Holterhus, Thomas Lehrnbecher
Invasive fungal diseases (IFDs) play an important role in the supportive care of paediatric patients with acute leukaemia and those undergoing allogeneic haematopoietic cell transplantation, and they are associated with significantly decreased overall survival rates in affected individuals. Relative to adults, children and adolescents are distinct in terms of host biology, predisposing conditions,
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Clinical factors associated with systemic sporotrichosis in Brazil Mycoses (IF 4.9) Pub Date : 2023-09-24 Vanessa C. R. Magalhães, Salene A. Colombo, Nalu T. A. Peres, Alexandre S. Moura, Ana C. Lyon, Sandra Lyon, Maria R. T. Dutra, Tatiani O. Fereguetti, Virginia A. Andrade, Maria I. Azevedo, Daniel A. Santos
Systemic sporotrichosis occurs when organs, other than subcutaneous tissues and lymph nodes, are infected. Interestingly, systemic sporotrichosis in apparently immunocompetent individuals is increasing in Brazil, but data on clinical manifestations and risk factors are scarce. Most of the existing data on such condition relate to people living with HIV. We aimed to study the risk factors associated