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Synthesis, Stereochemical Resolution, and Analogue Synthesis of Variabiline, an Aporphine Alkaloid That Sensitizes Acinetobacter baumannii and Klebsiella pneumoniae to Colistin ACS Infect. Dis. (IF 5.3) Pub Date : 2024-03-16 Haoting Li, Ansley M. Nemeth, Roberta J. Melander, Christian Melander
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Targeting Mycobacterium tuberculosis Persistence through Inhibition of the Trehalose Catalytic Shift ACS Infect. Dis. (IF 5.3) Pub Date : 2024-03-14 Karishma Kalera, Rachel Liu, Juhyeon Lim, Rasangi Pathirage, Daniel H. Swanson, Ulysses G. Johnson, Alicyn I. Stothard, Jae Jin Lee, Anne W. Poston, Peter J. Woodruff, Donald R. Ronning, Hyungjin Eoh, Benjamin M. Swarts
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Contributions of Hyperactive Mutations in Mpro from SARS-CoV-2 to Drug Resistance ACS Infect. Dis. (IF 5.3) Pub Date : 2024-03-12 Julia M. Flynn, Sarah N. Zvornicanin, Tenzin Tsepal, Ala M. Shaqra, Nese Kurt Yilmaz, Weiping Jia, Stephanie Moquin, Dustin Dovala, Celia A. Schiffer, Daniel N. A. Bolon
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Recent Advances in the Development of Polymyxin Antibiotics: 2010–2023 ACS Infect. Dis. (IF 5.3) Pub Date : 2024-03-12 Cornelis J. Slingerland, Nathaniel I. Martin
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Indole Propionic Acid Disturbs the Normal Function of Tryptophanyl-tRNA Synthetase in Mycobacterium tuberculosis ACS Infect. Dis. (IF 5.3) Pub Date : 2024-03-08 Xingli Han, Yamin Gao, Biao Zhou, H.M. Adnan Hameed, Cuiting Fang, Yanan Ju, Jing He, Xiange Fang, Zhiyong Liu, Wei Yu, Xiaoli Xiong, Nanshan Zhong, Tianyu Zhang
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Optimization of the Synthesis and Conjugation of the Methyl Rhamnan Tip of Pseudomonas aeruginosa A-Band Polysaccharide and Immunogenicity Evaluation for the Continued Development of a Potential Glycoconjugate Vaccine ACS Infect. Dis. (IF 5.3) Pub Date : 2024-03-06 Mohammad P. Jamshidi, Chantelle Cairns, Nam Huan Khieu, Kenneth Chan, Frank St. Michael, Andrew Cox, Janelle Sauvageau
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Ureidopenicillins Are Potent Inhibitors of Penicillin-Binding Protein 2 from Multidrug-Resistant Neisseria gonorrhoeae H041 ACS Infect. Dis. (IF 5.3) Pub Date : 2024-03-06 Jonathan M. Turner, Caleb M. Stratton, Sandeepchowdary Bala, Maria Cardenas Alvarez, Robert A. Nicholas, Christopher Davies
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Interactions between Gepotidacin and Escherichia coli Gyrase and Topoisomerase IV: Genetic and Biochemical Evidence for Well-Balanced Dual-Targeting ACS Infect. Dis. (IF 5.3) Pub Date : 2024-03-05 Alexandria A. Oviatt, Elizabeth G. Gibson, Jianzhong Huang, Karen Mattern, Keir C. Neuman, Pan F. Chan, Neil Osheroff
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Imbalanced EphB4/EphrinB2 Signaling Modulates Bone Resorption in Periodontitis Induced by Porphyromonas gingivalis ACS Infect. Dis. (IF 5.3) Pub Date : 2024-03-05 Ying Fu, Shuwei Zhang, Junchao Liu, Ze Lu, Yuchao Li, Jinwen Liu, Yaping Pan
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Synergistic Augmentation of Beta-Lactams: Exploring Quinoline-Derived Amphipathic Small Molecules as Antimicrobial Potentiators against Methicillin-Resistant Staphylococcus aureus ACS Infect. Dis. (IF 5.3) Pub Date : 2024-03-05 Surojit Ghosh, Samya Sen, Moumita Jash, Satyajit Ghosh, Aniket Jana, Rajsekhar Roy, Nabanita Mukherjee, Dipro Mukherjee, Jayita Sarkar, Surajit Ghosh
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Update on Journal Scope, Editorial Team, and Advisory Board Members for ACS Infectious Diseases ACS Infect. Dis. (IF 5.3) Pub Date : 2024-03-05 Jayanta Haldar
Dear Readers, As we step into the 10th year of publication of ACS Infectious Diseases, it is with great enthusiasm that I share with you some pivotal developments related to our journal. In response to the ever-expanding landscape of infectious diseases research, we have undertaken an initiative to broaden our scope, to encompass a wide spectrum of topics. In addition to the existing themes of the
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Investigation of Siderophore–Platinum(IV) Conjugates Reveals Differing Antibacterial Activity and DNA Damage Depending on the Platinum Cargo ACS Infect. Dis. (IF 5.3) Pub Date : 2024-03-04 Chuchu Guo, Kwo-Kwang A. Wang, Elizabeth M. Nolan
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Target-Mediated Fluoroquinolone Resistance in Neisseria gonorrhoeae: Actions of Ciprofloxacin against Gyrase and Topoisomerase IV ACS Infect. Dis. (IF 5.3) Pub Date : 2024-03-04 Jessica A. Collins, Alexandria A. Oviatt, Pan F. Chan, Neil Osheroff
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Peptide Dendrimer-Based Antibacterial Agents: Synthesis and Applications ACS Infect. Dis. (IF 5.3) Pub Date : 2024-03-01 Suchita Paul, Sandeep Verma, Yu-Chie Chen
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Protein O-Fucosyltransferase Is Required for the Efficient Invasion of Hepatocytes by Plasmodium berghei Sporozoites ACS Infect. Dis. (IF 5.3) Pub Date : 2024-02-29 Pratik Narain Srivastava, Plabita Paul, Satish Mishra
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Holistic One Health Surveillance Framework: Synergizing Environmental, Animal, and Human Determinants for Enhanced Infectious Disease Management ACS Infect. Dis. (IF 5.3) Pub Date : 2024-02-28 Samradhi Singh, Poonam Sharma, Namrata Pal, Devojit Kumar Sarma, Rajnarayan Tiwari, Manoj Kumar
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Synergistic Binding of SARS-CoV-2 to ACE2 and Gangliosides in Native Lipid Membranes ACS Infect. Dis. (IF 5.3) Pub Date : 2024-02-27 Manorama Dey, Anurag Sharma, Garvita Dhanawat, Divya Gupta, Krishnan H. Harshan, Nagma Parveen
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Proteomic Analysis of the Mycobacterium tuberculosis Outer Membrane for Potential Implications in Uptake of Small Molecules ACS Infect. Dis. (IF 5.3) Pub Date : 2024-02-24 Aseem Palande, Saniya Patil, Anjali Veeram, Soumya Swastik Sahoo, Tejan Lodhiya, Pankaj Maurya, Balaji Muralikrishnan, Jeetender Chugh, Raju Mukherjee
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Ubiquitin Ligase Parkin Regulates the Stability of SARS-CoV-2 Main Protease and Suppresses Viral Replication ACS Infect. Dis. (IF 5.3) Pub Date : 2024-02-22 Li Zhou, Ruochuan Liu, Heather Pathak, Xiaoyu Wang, Geon H. Jeong, Pratima Kumari, Mukesh Kumar, Jun Yin
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Understanding Antisense Oligonucleotide Efficiency in Inhibiting Prokaryotic Gene Expression ACS Infect. Dis. (IF 5.3) Pub Date : 2024-02-22 Sandra Story, Sayantan Bhaduri, Sudakshina Ganguly, Rambabu Dakarapu, Sarah L. Wicks, Jhuma Bhadra, Simeon Kwange, Dev P. Arya
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High Target Homology Does Not Guarantee Inhibition: Aminothiazoles Emerge as Inhibitors of Plasmodium falciparum ACS Infect. Dis. (IF 5.3) Pub Date : 2024-02-17 Sandra Johannsen, Robin M. Gierse, Arne Krüger, Rachel L. Edwards, Vittoria Nanna, Anna Fontana, Di Zhu, Tiziana Masini, Lais Pessanha de Carvalho, Mael Poizat, Bart Kieftenbelt, Dana M. Hodge, Sophie Alvarez, Daan Bunt, Antoine Lacour, Atanaz Shams, Kamila Anna Meissner, Edmarcia Elisa de Souza, Melloney Dröge, Bernard van Vliet, Jack den Hartog, Michael C. Hutter, Jana Held, Audrey R. Odom John,
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Characterization of a Myeloid Differentiation Factor 2-Derived Peptide that Facilitates THP-1 Macrophage-Mediated Phagocytosis of Gram-Negative Bacteria ACS Infect. Dis. (IF 5.3) Pub Date : 2024-02-16 Anshika Tandon, Munesh Kumar Harioudh, Neeraj Kumar Verma, Jyotshana Saroj, Arvind Gupta, Garima Pant, Jitendra Kumar Tripathi, Amit Kumar, Tripti Kumari, Amit Kumar Tripathi, Kalyan Mitra, Jimut Kanti Ghosh
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N-Substituted Bicyclic Carbamoyl Pyridones: Integrase Strand Transfer Inhibitors that Potently Inhibit Drug-Resistant HIV-1 Integrase Mutants ACS Infect. Dis. (IF 5.3) Pub Date : 2024-02-12 Pankaj S. Mahajan, Steven J. Smith, Min Li, Robert Craigie, Stephen H. Hughes, Xue Zhi Zhao, Terrence R. Burke, Jr.
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Isofagomine Inhibits Multiple TcdB Variants and Protects Mice from Clostridioides difficile-Induced Mortality ACS Infect. Dis. (IF 5.3) Pub Date : 2024-02-09 Ashleigh S. Paparella, Isabella Brew, Huynh A. Hong, William Ferriera, Simon Cutting, Farah Lamiable-Oulaidi, Michael Popadynec, Peter C. Tyler, Vern L. Schramm
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Antifungal and Antiparasitic Activities of Metallocene-Containing Fluconazole Derivatives ACS Infect. Dis. (IF 5.3) Pub Date : 2024-02-08 Yan Lin, Gonzalo Scalese, Christina A. Bulman, Robin Vinck, Olivier Blacque, Margot Paulino, Andres Ballesteros-Casallas, Leticia Pérez Díaz, Gustavo Salinas, Makedonka Mitreva, Tobias Weil, Kevin Cariou, Judy A. Sakanari, Dinorah Gambino, Gilles Gasser
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Extracellular Vesicles in Malaria: Shedding Light on Pathogenic Depths ACS Infect. Dis. (IF 5.3) Pub Date : 2024-02-06 Sangita Dey, Salini Mohapatra, Manoj Khokhar, Sana Hassan, Rajan Kumar Pandey
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Interleukin-22 Contributes to Blood–Brain Barrier Disruption via STAT3/VEGFA Activation in Escherichia coli Meningitis ACS Infect. Dis. (IF 5.3) Pub Date : 2024-02-06 Ruicheng Yang, Jiaqi Chen, Xinyi Qu, Hulin Liu, Xinyi Wang, Chen Tan, Huanchun Chen, Xiangru Wang
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Rational Design of a Potent Antimicrobial Peptide Based on the Active Region of a Gecko Cathelicidin ACS Infect. Dis. (IF 5.3) Pub Date : 2024-02-05 Ying Cai, Xingyu Wang, Tianyu Zhang, An Yan, Lin Luo, Chenxi Li, Gengzhou Tian, Zhongxiang Wu, Xi Wang, Dong Shen, Yajun Han, Zhiye Zhang
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Dronedarone Enhances the Antibacterial Activity of Polymyxin B and Inhibits the Quorum Sensing System by Interacting with LuxS ACS Infect. Dis. (IF 5.3) Pub Date : 2024-02-05 Ruiqin Cui, Jinyong Zhang, Xiaodi Liu, Chunxia Hu, Fan Zhou, Min Zhang, Xiao Wang, Quanming Zou, Wei Huang
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Chloramphenicol Binding Sites of Acinetobacter baumannii Chloramphenicol Acetyltransferase CatB8 ACS Infect. Dis. (IF 5.3) Pub Date : 2024-02-04 Jing Liao, Qianqian Qi, Linghan Kuang, Yanxia Zhou, Qingjie Xiao, Ting Liu, Xiang Wang, Li Guo, Yongmei Jiang
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Addressing Antimicrobial Properties in Guided Tissue/Bone Regeneration Membrane: Enhancing Effectiveness in Periodontitis Treatment ACS Infect. Dis. (IF 5.3) Pub Date : 2024-02-01 Sara Takallu, Esmaeil Mirzaei, Abbas Zakeri Bazmandeh, Hamid Reza Ghaderi Jafarbeigloo, Hooman Khorshidi
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Chitosan-Coated Silver Nanoparticles Inhibit Adherence and Biofilm Formation of Uropathogenic Escherichia coli ACS Infect. Dis. (IF 5.3) Pub Date : 2024-01-29 Pablo Mendez-Pfeiffer, Manuel G. Ballesteros-Monrreal, Josue Juarez, Marisol Gastelum-Cabrera, Patricia Martinez-Flores, Pablo Taboada, Dora Valencia
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Xanthone Derivatives Enhance the Therapeutic Potential of Neomycin against Polymicrobial Gram-Negative Bacterial Infections ACS Infect. Dis. (IF 5.3) Pub Date : 2024-01-31 Sayed Mohamad Safwan, Neeraj Kumar, Devashish Mehta, Mohit Singh, Varsha Saini, Nishant Pandey, Steffi Khatol, Shalini Batheja, Jitender Singh, Preeti Walia, Avinash Bajaj
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Unlocking Opportunities for Mycobacterium leprae and Mycobacterium ulcerans ACS Infect. Dis. (IF 5.3) Pub Date : 2024-01-31 Mousumi Shyam, Sumit Kumar, Vinayak Singh
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Mechanism of Protease Resistance of D-Amino Acid Residue Containing Cationic Antimicrobial Heptapeptides ACS Infect. Dis. (IF 5.3) Pub Date : 2024-01-31 Tanumoy Sarkar, Suvankar Ghosh, Pradeep Kumar Sundaravadivelu, Gopal Pandit, Swapna Debnath, Rajkumar P. Thummer, Priyadarshi Satpati, Sunanda Chatterjee
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Extracellular Vehicles from Commensal Skin Malassezia restricta Inhibit Staphylococcus aureus Proliferation and Biofilm Formation ACS Infect. Dis. (IF 5.3) Pub Date : 2024-01-31 Xin Liu, Xiaoyu Guo, Xiaomin Su, Bingru Ji, Yawei Chang, Qichao Huang, Yuan Zhang, Xiaobing Wang, Pan Wang
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Azomycin Orchestrate Colistin-Resistant Enterobacter cloacae Complex’s Colistin Resistance Reversal In Vitro and In Vivo ACS Infect. Dis. (IF 5.3) Pub Date : 2024-01-31 Panjie Hu, Huanchang Chen, Deyi Zhao, Zhexiao Ma, Weiliang Zeng, Yijia Han, Tieli Zhou, Jianming Cao, Mo Shen
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Minimum Information for Conducting and Reporting In Vitro Intracellular Infection Assays ACS Infect. Dis. (IF 5.3) Pub Date : 2024-01-31 Santhni Subramaniam, Paul Joyce, Abiodun D. Ogunniyi, Admire Dube, Samantha L. Sampson, Claus-Michael Lehr, Clive A. Prestidge
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Insights into Peptidoglycan-Targeting Radiotracers for Imaging Bacterial Infections: Updates, Challenges, and Future Perspectives ACS Infect. Dis. (IF 5.3) Pub Date : 2024-01-30 Palesa C. Koatale, Mick M. Welling, Honest Ndlovu, Mankgopo Kgatle, Sipho Mdanda, Amanda Mdlophane, Ambrose Okem, John Takyi-Williams, Mike M. Sathekge, Thomas Ebenhan
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Chelation of Mitochondrial Iron as an Antiparasitic Strategy ACS Infect. Dis. (IF 5.3) Pub Date : 2024-01-30 Dominik Arbon, Jan Mach, Aneta Čadková, Anna Sipkova, Jan Stursa, Kristýna Klanicová, Marta Machado, Markus Ganter, Viktoriya Levytska, Daniel Sojka, Jaroslav Truksa, Lukáš Werner, Robert Sutak
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Heterologous Sarbecovirus Receptor Binding Domains as Scaffolds for SARS-CoV-2 Receptor Binding Motif Presentation ACS Infect. Dis. (IF 5.3) Pub Date : 2024-01-28 Blake M. Hauser, Maya Sangesland, Evan C. Lam, Kerri J. St Denis, Maegan L. Sheehan, Mya L. Vu, Agnes H. Cheng, Sophia Sordilla, Dana Thornlow Lamson, Ahmad W. Almawi, Alejandro B. Balazs, Daniel Lingwood, Aaron G. Schmidt
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Enhanced Antimalarial and Antisequestration Activity of Methoxybenzenesulfonate-Modified Biopolymers and Nanoparticles for Tackling Severe Malaria ACS Infect. Dis. (IF 5.3) Pub Date : 2024-01-25 Adrian Najer, Junyoung Kim, Catherine Saunders, Junyi Che, Jake Baum, Molly M. Stevens
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A Mechanistic Understanding of the Modes of Ca2+ Ion Binding to the SARS-CoV-1 Fusion Peptide and Their Role in the Dynamics of Host Membrane Penetration ACS Infect. Dis. (IF 5.3) Pub Date : 2024-01-25 Juliana Debrito Carten, George Khelashvili, Miya K. Bidon, Marco R. Straus, Tiffany Tang, Javier A. Jaimes, Gary R. Whittaker, Harel Weinstein, Susan Daniel
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A Non-Active-Site Inhibitor with Selectivity for Zika Virus NS2B-NS3 Protease ACS Infect. Dis. (IF 5.3) Pub Date : 2024-01-24 Kristalle G. Cruz, Maureen Hill Eron, Sparsh Makhaik, Sergey Savinov, Jeanne A. Hardy
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Pyridyl-Linked Hetero Hydrazones: Transmembrane H+/Cl– Symporters with Efficient Antibacterial Activity ACS Infect. Dis. (IF 5.3) Pub Date : 2024-01-23 Abhishek Mondal, Manisha Siwach, Manzoor Ahmad, Sunish Kumar Radhakrishnan, Pinaki Talukdar
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Iron Sequestration by Murine Calprotectin Induces Starvation Responses in Pseudomonas aeruginosa ACS Infect. Dis. (IF 5.3) Pub Date : 2024-01-23 Janet J. Y. Peet, Angelica D. Phan, Amanda G. Oglesby, Elizabeth M. Nolan
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How do Antimicrobial Peptides Interact with the Outer Membrane of Gram-Negative Bacteria? Role of Lipopolysaccharides in Peptide Binding, Anchoring, and Penetration ACS Infect. Dis. (IF 5.3) Pub Date : 2024-01-23 Justus C. Stephani, Luca Gerhards, Bishoy Khairalla, Ilia A. Solov’yov, Izabella Brand
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Vancomycin-Polyguanidino Dendrimer Conjugates Inhibit Growth of Antibiotic-Resistant Gram-Positive and Gram-Negative Bacteria and Eradicate Biofilm-Associated S. aureus ACS Infect. Dis. (IF 5.3) Pub Date : 2024-01-22 Madeline B. Chosy, Jiuzhi Sun, Harrison P. Rahn, Xinyu Liu, Jasna Brčić, Paul A. Wender, Lynette Cegelski
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Analyses of the Antibiofilm Activity of o-Phenanthroline Monohydrate against Enterococcus faecalis and Staphylococcus aureus and the Mechanisms Underlying These Effects ACS Infect. Dis. (IF 5.3) Pub Date : 2024-01-22 Yu Wang, Zhouhui Wu, Zhiwen Wang, Heng Du, Shuang Xiao, Lin Lu, Zhen Wang
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PEtN-Modified O-Antigen Enhances Shigella Pathogenesis by Promoting Epithelial Cell Invasion and Inhibiting Complement Binding ACS Infect. Dis. (IF 5.3) Pub Date : 2024-01-22 Ruicheng Zheng, Wan Li, Wenjuan Yin, Lu Qiao, Shikai Song, Yina An, Zhuoren Ling, Li Bai, Hui Yang, Jianzhong Shen, Yanjun Dong, Yang Wang
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Hfe Permease and Haemophilus influenzae Manganese Homeostasis ACS Infect. Dis. (IF 5.3) Pub Date : 2024-01-19 Katherine Ganio, Marufa Nasreen, Zihao Yang, Eve A. Maunders, Zhenyao Luo, Sheikh Imamul Hossain, Dalton H. Y. Ngu, Daniel Ellis, Jin Gu, Stephanie L. Neville, Jonathan Wilksch, Adam P. Gunn, Jonathan J. Whittall, Boštjan Kobe, Evelyne Deplazes, Ulrike Kappler, Christopher A. McDevitt
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Amphiphilic Dendrimer as Potent Antibacterial against Drug-Resistant Bacteria in Mouse Models of Human Infectious Diseases ACS Infect. Dis. (IF 5.3) Pub Date : 2024-01-19 Noah King, Dinesh Dhumal, Shi Qian Lew, Shanny Hsuan Kuo, Christina Galanakou, Myung Whan Oh, Sook Yin Chong, Nian Zhang, Leo Tsz On Lee, Zvi Hayouka, Ling Peng, Gee W. Lau
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Four-Arm δ-Ornithine-Based Polypeptoids Resensitize Voriconazole against Azole-Resistant C. albicans ACS Infect. Dis. (IF 5.3) Pub Date : 2024-01-19 Yuanqiao Cao, Miaomiao Han, Shengxiang Ji
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Identification of Chemical Scaffolds Targeting Drug-Resistant and Latent Mycobacterium tuberculosis through High-Throughput Whole-Cell Screening ACS Infect. Dis. (IF 5.3) Pub Date : 2024-01-18 Summaya Perveen, Anjali Negi, Sapna Saini, Anjali Gangwar, Rashmi Sharma
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Progress in Treatment and Diagnostics of Infectious Disease with Polymers ACS Infect. Dis. (IF 5.3) Pub Date : 2024-01-18 Sukanya Patra, Divya Pareek, Prem Shankar Gupta, Kirti Wasnik, Gurmeet Singh, Desh Deepak Yadav, Yitzhak Mastai, Pradip Paik
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Antimicrobial Activity of Trigonelline Hydrochloride Against Pseudomonas aeruginosa and Its Quorum-Sensing Regulated Molecular Mechanisms on Biofilm Formation and Virulence ACS Infect. Dis. (IF 5.3) Pub Date : 2024-01-17 Amiya Kar, Samir Kumar Mukherjee, Subhasis Barik, Sk Tofajjen Hossain
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Current Development of Thiazole-Containing Compounds as Potential Antibacterials against Methicillin-Resistant Staphylococcus aureus ACS Infect. Dis. (IF 5.3) Pub Date : 2024-01-17 Hang Liu, Ting Xu, Zihan Xue, Meijuan Huang, Tingting Wang, Miaomiao Zhang, Ruige Yang, Yong Guo
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The Hybrid Antibiotic Thiomarinol A Overcomes Intrinsic Resistance in Escherichia coli Using a Privileged Dithiolopyrrolone Moiety ACS Infect. Dis. (IF 5.3) Pub Date : 2024-01-16 Rachel M. Johnson, Kelin Li, Xiaoyan Chen, Gina L. Morgan, Jeffrey Aubé, Bo Li
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The Forgotten Pioneer ACS Infect. Dis. (IF 5.3) Pub Date : 2024-01-12 Tatiana I. Román V
The artwork showcased on this journal’s cover (ACS Infectious Diseases, January 2024) is inspired by Alice Ball, an African American chemist who pioneered a treatment for Hansen’s disease, commonly known as leprosy, in the early 20th century. It was the only effective treatment against leprosy until the advent of antibiotics in the 1940s. Alice Ball confronted the prevalent stereotypes of her era,
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Inorganic Polyphosphate Affects Biofilm Assembly, Capsule Formation, and Virulence of Hypervirulent ST23 Klebsiella pneumoniae ACS Infect. Dis. (IF 5.3) Pub Date : 2024-01-11 Diego Rojas, Andrés E. Marcoleta, Matías Gálvez-Silva, Macarena A. Varas, Mauricio Díaz, Mauricio Hernández, Cristian Vargas, Guillermo Nourdin-Galindo, Elard Koch, Pablo Saldivia, Jorge Vielma, Yunn-Hwen Gan, Yahua Chen, Nicolás Guiliani, Francisco P. Chávez