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Difficult-to-treat HIV in Sweden: a cross-sectional study BMC Infect. Dis. (IF 3.7) Pub Date : 2024-03-18 Olof Elvstam, Viktor Dahl, Anna Weibull Wärnberg, Susanne von Stockenström, Aylin Yilmaz
Our aim was to examine the prevalence and characteristics of difficult-to-treat HIV in the current Swedish HIV cohort and to compare treatment outcomes between people with difficult and non-difficult-to-treat HIV. In this cross-sectional analysis of the Swedish HIV cohort, we identified all people with HIV currently in active care in 2023 from the national register InfCareHIV. We defined five categories
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Association of interleukin-6, ferritin, and lactate dehydrogenase with venous thromboembolism in COVID-19: a systematic review and meta-analysis BMC Infect. Dis. (IF 3.7) Pub Date : 2024-03-16 Haiyu Liu, Ningjing Guo, Qixian Zheng, Qianyuan Zhang, Jinghan Chen, Yuanyuan Cai, Qiong Luo, Qian Xu, Xiangqi Chen, Sheng Yang, Suyun Zhang
Coronavirus disease 2019 (COVID-19) is frequntly accompanied by venous thromboembolism (VTE), and its mechanism may be related to the abnormal inflammation and immune status of COVID-19 patients. It has been proved that interleukin-6 (IL-6), ferritin and lactate dehydrogenase (LDH) may play an important role in the occurrence of VTE in COVID-19 infection. But whether they can server as predictors for
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Rare case of septic shock combined with meningitis caused by Pasteurella multocida without a history of cat and dog bites BMC Infect. Dis. (IF 3.7) Pub Date : 2024-03-15 Yijun Zhu, Fang Zhu, Xiaoyun Shan, Jingchao Shi
Pasteurella multocida is a zoonotic pathogen that mainly causes local skin and soft tissue infections in the human body through cat and dog bites. It rarely causes bacteraemia (or sepsis) and meningitis. We reported a case of septic shock and meningitis caused by P. multocida in a patient without a history of cat and dog bites. An 84-year-old male patient was urgently sent to the emergency department
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Clinical presentation and management of multisystem inflammatory syndrome in children associated with covid-19: a retrospective observational descriptive study in a pediatric hospital in Syria BMC Infect. Dis. (IF 3.7) Pub Date : 2024-03-15 Eman Shhada, Hussein Hamdar, Ali Alakbar Nahle, Diana Mourad, Basheer Khalil, Sawssan Ali
Multisystem Inflammatory Syndrome in Children (MIS-C) associated with COVID-19 is a rare and serious medical condition. This study aims to review the clinical presentation, laboratory parameters, outcomes, and management of MIS-C cases in a pediatric hospital in Syria. This retrospective observational study aimed to investigate MIS-C between May 2020 and October 2021. Data collection involved extracting
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Circulating vaccine derived polio virus type 2 outbreak and response in Yemen, 2021–2022, a retrospective descriptive analysis BMC Infect. Dis. (IF 3.7) Pub Date : 2024-03-15 Mutahar Ahmed Al-Qassimi, Mohammed Al Amad, Ahmed Al-Dar, Ehab Al Sakaf, Ahmed Al Hadad, Yahia Ahmed Raja’a
The outbreaks of circulating Vaccine Derived Polio Viruses (cVDPVs) have emerged as a major challenge for the final stage of polio eradication. In Yemen, an explosive outbreak of cVDPV2 was reported from August 2021 to December 2022. This study aims to compare the patterns of cVDPV2 outbreak, response measures taken by health authorities, and impacts in southern and northern governorates. A retrospective
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Antimicrobial resistance markers distribution in Staphylococcus aureus from Nsukka, Nigeria BMC Infect. Dis. (IF 3.7) Pub Date : 2024-03-15 Martina C. Agbo, Ifeoma M. Ezeonu, Beatrice O. Onodagu, Chukwuemeka C. Ezeh, Chizoba A. Ozioko, Stephen C. Emencheta
Multidrug resistance in Staphylococcus aureus continues to influence treatment complications in clinical settings globally. Multidrug-resistant-S. aureus (MDR-SA) is often genetically driven by resistance markers transferable in pathogenic strains. This study aimed to determine the distribution of resistance markers in clinical isolates of S. aureus in Nsukka, Nigeria. A total of 154 clinical samples
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Dengue encephalopathy in an adult due to dengue virus type 1 infection BMC Infect. Dis. (IF 3.7) Pub Date : 2024-03-15 Xingyu Leng, Huiqin Yang, Lingzhai Zhao, Jiamin Feng, Kanghong Jin, Lu Liao, Fuchun Zhang
Dengue is an important public health problem, which caused by the dengue virus (DENV), a single-stranded RNA virus consisted of four serotypes. Central nervus system (CNS) impairment in dengue usually results from DENV-2 or DENV-3 infection, which lead to life-threatening outcomes. Furthermore, neurological complications due to DENV-1 was rare especially in adult patients. A 44-year-old man without
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Prevalence of vaccine-derived hepatitis B surface antibodies in children and adolescents in Germany: results from a population-based survey, 2014–2017 BMC Infect. Dis. (IF 3.7) Pub Date : 2024-03-15 Ida Sperle, Sofie Gillesberg Lassen, Martin Schlaud, Achim Dörre, Sandra Dudareva, Christina Poethko-Müller, Thomas Harder
Childhood vaccination against hepatitis B has been recommended in Germany since 1995. WHO defines a primary vaccination series as successful if the initial hepatitis B surface antibody (anti-HBs) level is ≥ 10 IU/L directly after vaccination. Anti-HBs levels vary depending on the number of doses, type of vaccine, and time interval between the last two doses. In 2021, Germany began to recommend three
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Clinical spectrum and long-term outcomes of mpox: a cohort study spanning from acute infection to six-month follow-up BMC Infect. Dis. (IF 3.7) Pub Date : 2024-03-15 Christoph Zeyen, Maria Kinberger, Helene Kriedemann, Frieder Pfäfflin, Pinkus Tober-Lau, Leu Huang, Victor Max Corman, Alexander Nast, Leif Erik Sander, Florian Kurth, Ricardo Niklas Werner
Cases of mpox have been reported worldwide since May 2022. Limited knowledge exists regarding the long-term course of this disease. To assess sequelae in terms of scarring and quality of life (QoL) in mpox patients 4–6 months after initial infection. Prospective observational study on clinical characteristics and symptoms of patients with polymerase chain reaction (PCR)-confirmed mpox, including both
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HIV protease resistance mutations in patients receiving second-line antiretroviral therapy in Libreville, Gabon BMC Infect. Dis. (IF 3.7) Pub Date : 2024-03-14 Guy Francis Nzengui-Nzengui, Gaël Mourembou, Hervé M’boyis-Kamdem, Ayawa Claudine Kombila-Koumavor, Angélique Ndjoyi-Mbiguino
In 2022, the WHO reported that 29.8 million people around the world were living with HIV (PLHIV) and receiving antiretroviral treatment (ART), including 25 375 people in Gabon (54% of all those living with HIV in the country). The literature reports a frequency of therapeutic failure with first-line antiretrovirals (ARVs) of between 20% and 82%. Unfortunately, data relating to the failure of second-line
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Characteristics of reproductive tract infections caused by common pathogens among the outpatients of reproductive medicine center in Putian: retrospective study BMC Infect. Dis. (IF 3.7) Pub Date : 2024-03-14 Jiancheng Zeng, Tingli Wu, Laiping Wang, Liumin Yu, Hua Lin, Zhanfei Chen
This study aims to explore the infection and age distribution of Ureaplasma urealyticum (UU), Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG) and Herpes simplex virus type II (HSV II) among the outpatients of Reproductive Medicine Center in Putian, Fujian Province to provide a clinical basis for the early diagnosis and treatment of various reproductive tract diseases and infertility in this
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Spatio-temporal spread and evolution of Lassa virus in West Africa BMC Infect. Dis. (IF 3.7) Pub Date : 2024-03-14 Xia Wang, Xianwei Ye, Ruihua Li, Xiaodong Zai, Mingda Hu, Shaoyan Wang, Hongguang Ren, Yuan Jin, Junjie Xu, Junjie Yue
Lassa fever is a hemorrhagic disease caused by Lassa virus (LASV), which has been classified by the World Health Organization as one of the top infectious diseases requiring prioritized research. Previous studies have provided insights into the classification and geographic characteristics of LASV lineages. However, the factor of the distribution and evolution characteristics and phylodynamics of the
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A multi-country comparative study of two treponemal tests for the serodiagnosis of syphilis amongst men who have sex with men (MSM): Chemo-luminescent assay vs Treponema pallidum particle agglutination assay BMC Infect. Dis. (IF 3.7) Pub Date : 2024-03-14 Lorenzo Gios, Massimo Mirandola, Maddalena Cordioli, Antonella Zorzi, Nigel Sherriff, Jaime Vera, Dominika Wlazly, Mohammed Osman Hassan-Ibrahim, Valeska Padovese, Anabel Darmanin, Rosanna W. Peeling, Magnus Unemo, Karel Blondeel, Igor Toskin
International guidelines recommend routine screening for syphilis (aetiological agent: Treponema pallidum subspecies pallidum) amongst key populations and vulnerable populations using tests detecting treponemal and non-treponemal antibodies. Whilst treponemal tests have high sensitivities and specificities, they differ regarding subjective or objective interpretation, throughput and workload. Chemiluminescence
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Determinants of viral load suppression failure among HIV adults on ARV attending health care facilities: a retrospective study in Tanga region, Tanzania BMC Infect. Dis. (IF 3.7) Pub Date : 2024-03-14 Eric Mboggo, Expeditho Mtisi, Stella E. Mushy, Simon Mkawe, Frida Ngalesoni, Aisa Muya, Edwin Kilimba, Denice Kamugumya, Boniface Silvan Mlay
Availability and accessibility of Antiretroviral drugs (ARV’s) improve the lives of People living with HIV (PLHIV) by improving client’s immune system to overcome infections and prevent the development of AIDS and other HIV complications. Combination therapy, early initiation of ART, newer ART drugs, single dosage and drug affordability significantly contribute in the reduction of viral multiplication
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Knowledge, perceptions, and exposure to bats in communities living around bat roosts in Bundibugyo district, Uganda: implications for viral haemorrhagic fever prevention and control BMC Infect. Dis. (IF 3.7) Pub Date : 2024-03-14 Lesley Rose Ninsiima, Luke Nyakarahuka, Steven Kisaka, Collins GK. Atuheire, Lawrence Mugisha, Terence Odoch, Javier Sánchez Romano, Jörn Klein, Siobhan M. Mor, Clovice Kankya
Bats are a reservoir for many viruses causing haemorrhagic fevers. Proximity to bats is a risk factor for virus spillover to animals and humans. We conducted this study to assess knowledge, perceptions, and exposure to bats in communities living near bat roosts in Bundibugyo District, Uganda. A cross-sectional study using mixed methods with both quantitative and qualitative data was conducted between
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Isolation and characterization of lytic bacteriophages from various sources in Addis Ababa against antimicrobial-resistant diarrheagenic Escherichia coli strains and evaluation of their therapeutic potential BMC Infect. Dis. (IF 3.7) Pub Date : 2024-03-14 Tamirat Salile Sada, Tesfaye Sisay Tessema
Escherichia coli is a common fecal coliform, facultative aerobic, gram-negative bacterium. Pathogenic strains of such microbes have evolved to cause diarrhea, urinary tract infections, and septicemias. The emergence of antibiotic resistance urged the identification of an alternative strategy. The use of lytic bacteriophages against the control of pathogenic E. coli in clinics and different environmental
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Remote surveillance and detection of SARS-CoV-2 transmission among household members in King County, Washington BMC Infect. Dis. (IF 3.7) Pub Date : 2024-03-13 Anne Emanuels, Amanda M. Casto, Jessica Heimonen, Jessica O’Hanlon, Eric J. Chow, Constance Ogokeh, Melissa A. Rolfes, Peter D. Han, James P. Hughes, Timothy M. Uyeki, Christian Frazar, Erin Chung, Lea M. Starita, Janet A. Englund, Helen Y. Chu
Early during the COVID-19 pandemic, it was important to better understand transmission dynamics of SARS-CoV-2, the virus that causes COVID-19. Household contacts of infected individuals are particularly at risk for infection, but delays in contact tracing, delays in testing contacts, and isolation and quarantine posed challenges to accurately capturing secondary household cases. In this study, 346
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Diagnosis of pulmonary Scedosporium apiospermum infection from bronchoalveolar lavage fluid by metagenomic next-generation sequencing in an immunocompetent female patient with normal lung structure: a case report and literature review BMC Infect. Dis. (IF 3.7) Pub Date : 2024-03-13 Jingru Han, Lifang Liang, Qingshu Li, Ruihang Deng, Chenyang Liu, Xuekai Wu, Yuxin Zhang, Ruowen Zhang, Haiyun Dai
Scedosporium apiospermum (S. apiospermum) belongs to the asexual form of Pseudallescheria boydii and is widely distributed in various environments. S. apiospermum is the most common cause of pulmonary infection; however, invasive diseases are usually limited to patients with immunodeficiency. A 54-year-old Chinese non-smoker female patient with normal lung structure and function was diagnosed with
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Gram-negative bacterial colonizations before bilateral lung transplant. The impact of ‘targeted’ versus ‘standard’ surgical prophylaxis BMC Infect. Dis. (IF 3.7) Pub Date : 2024-03-13 Sabrina Congedi, Arianna Peralta, Luisa Muraro, Martina Biscaro, Tommaso Pettenuzzo, Nicolò Sella, Silvia Crociani, Arméla Anne-Sabine Tagne, Ida Caregnato, Francesco Monteleone, Elisa Rossi, Gabriella Roca, Silvia Manfrin, Serena Marinello, Maria Mazzitelli, Andrea Dell’Amore, Annamaria Cattelan, Federico Rea, Paolo Navalesi, Annalisa Boscolo
Infections are one of the most common causes of death after lung transplant (LT). However, the benefit of ‘targeted’ prophylaxis in LT recipients pre-colonized by Gram-negative (GN) bacteria is still unclear. All consecutive bilateral LT recipients admitted to the Intensive Care Unit of the University Hospital of Padua (February 2016–2023) were retrospectively screened. Only patients with pre-existing
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Bloodstream infection clusters for critically ill patients: analysis of two-center retrospective cohorts BMC Infect. Dis. (IF 3.7) Pub Date : 2024-03-13 Lei Wang, Li Zhang, Xiaolong Huang, Hao Xu, Wei Huang
Bloodstream infections (BSI) are highly prevalent in hospitalized patients requiring intensive care. They are among the most serious infections and are highly associated with sepsis or septic shock, which can lead to prolonged hospital stays and high healthcare costs. This study aimed at establishing an easy-to-use nomogram for predicting the prognosis of patients with BSI. In retrospective study,
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H. pylori infection and osteoporosis: a large-scale observational and mendelian randomization study BMC Infect. Dis. (IF 3.7) Pub Date : 2024-03-12 Ling Zhang, Daya Zhang, Ling Wei, Yan Zhou, Ximei Li, Runxiang Chen, Xiaodong Zhang, Shiju Chen, Feihu Bai
There is controversy concerning the relationship between Helicobacter pylori (H. pylori) infection and osteoporosis. This study is to examine the causal relationship between H. pylori infection and osteoporosis and to analyze the potential mechanism underlying the relationship. The clinical data of H. pylori infection and bone mineral density from patients or physical examiner with good general condition
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Predictors of COVID-19 vaccine uptake: an online three-wave survey study of US adults BMC Infect. Dis. (IF 3.7) Pub Date : 2024-03-12 Alistair Thorpe, Angela Fagerlin, Frank A. Drews, Holly Shoemaker, Federica S. Brecha, Laura D. Scherer
To effectively promote vaccine uptake, it is important to understand which people are most and least inclined to be vaccinated and why. In this study, we examined predictors of COVID-19 vaccine uptake and reasons for non-vaccination. We conducted an online English-language survey study in December-2020, January-2021, and March-2021. A total of 930 US respondents completed all surveys. Multiple logistic
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Diarrheal disease and associated factors among children aged 6 to 59 months in Oda Bultum District, Eastern Ethiopia: a community-based cross-sectional study BMC Infect. Dis. (IF 3.7) Pub Date : 2024-03-12 Zewudalem Getachew, Nega Asefa, Tigist Gashaw, Abdi Birhanu, Adera Debella, Bikila Balis, Usmael Jibro, Sina Tolera, Aboma Motuma, Mulugeta Gamachu, Alemayehu Deressa, Fethia Mohammed, Moti Tolera, Addis Eyeberu, Lemma Demissie Regassa, Ibsa Mussa
Diarrhea is a serious health problem in children under the age of five that is both preventable and treatable. In low-income countries like Ethiopia, children under the age five years frequently experience diarrhea. However, the burden and associated factors of these diarrheal diseases are understudied in Eastern Ethiopia, Thus, this study aimed to determine the factors associated with the prevalence
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Analysis of viral pneumonia and risk factors associated with severity of influenza virus infection in hospitalized patients from 2012 to 2016 BMC Infect. Dis. (IF 3.7) Pub Date : 2024-03-12 M. I. Fullana Barceló, F. Artigues Serra, A. R. Millan Pons, J. Asensio Rodriguez, A. Ferre Beltran, M. del Carmen Lopez Bilbao, J. Reina Prieto, M. Riera Jaume
Influenza viruses cause pneumonia in approximately one-third of cases, and pneumonia is an important cause of death. The aim was to identify risk factors associated with severity and those that could predict the development of pneumonia. This retrospective, observational study included all adult patients with confirmed influenza virus infection admitted to Son Espases University Hospital during four
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Experience of social harms among female sex workers following HIV self-test distribution in Malawi: results of a cohort study BMC Infect. Dis. (IF 3.7) Pub Date : 2024-03-11 Paul Mee, Melissa Neuman, Moses Kumwenda, Wezzie S. Lora, Simon Sikwese, Mwiza Sambo, Katherine Fielding, Pitchaya P. Indravudh, Karin Hatzold, Cheryl Johnson, Elizabeth. L. Corbett, Nicola Desmond
In Malawi, female sex workers (FSW) have high HIV incidence and regular testing is suggested. HIV self-testing (HIVST) is a safe and acceptable alternative to standard testing services. This study assessed; whether social harms were more likely to be reported after HIVST distribution to FSW by peer distributors than after facility-based HIV testing and whether FSW regretted HIVST use or experienced
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Impact of ITPA gene polymorphism for predicting anemia and treatment outcome in HCV infected patients taking Sofosbuvir Ribavirin therapy BMC Infect. Dis. (IF 3.7) Pub Date : 2024-03-11 Sameen Amjed, Hafiz Ghulam Murtaza Saleem, Sajjad Ullah, Shahzad Latif, Shabana, Junaid Jafar, Ahmad Bilal Waqar
Globally, 80 million people are suffering from chronic Hepatitis C virus (HCV) infection. Sofosbuvir ribavirin-based anti-HCV therapy is associated with anemia and other adverse effects. Polymorphisms of Inosine triphosphatase (ITPA) gene may cause functional impairment in the Inosine triphosphate pyrophosphatase enzyme, resulting in enhanced sustained viral response (SVR) and protection from ribavirin-associated
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Post-recovery health domain scores among outpatients by SARS-CoV-2 testing status during the pre-Delta period BMC Infect. Dis. (IF 3.7) Pub Date : 2024-03-08 Jennifer P. King, Jessie R. Chung, James G. Donahue, Emily T. Martin, Aleda M. Leis, Arnold S. Monto, Manjusha Gaglani, Kayan Dunnigan, Chandni Raiyani, Sharon Saydah, Brendan Flannery, Edward A. Belongia
Symptoms of COVID-19 including fatigue and dyspnea, may persist for weeks to months after SARS-CoV-2 infection. This study compared self-reported disability among SARS-CoV-2-positive and negative persons with mild to moderate COVID-19-like illness who presented for outpatient care before widespread COVID-19 vaccination. Unvaccinated adults with COVID-19-like illness enrolled within 10 days of illness
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The burden of skin and soft tissue, bone and joint infections in an Australian cohort of people who inject drugs BMC Infect. Dis. (IF 3.7) Pub Date : 2024-03-07 B. Morgan, R. Lancaster, B. Boyagoda, R. Ananda, LO Attwood, D. Jacka, I. Woolley
There are currently limited data regarding the clinical and economic significance of skin and soft tissue infections (SSTI) and bone and joint infections in Australian people who inject drugs (PWID). Retrospective cohort study in adult PWID admitted to Monash Health, a large heath care network with six hospitals in Victoria, Australia. Inpatients were identified using administrative datasets and International
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Genotypic study of Chlamydia trachomatis for lymphogranuloma venereum diagnosis in rectal specimens from men who have sex with men: a cost-effectiveness analysis BMC Infect. Dis. (IF 3.7) Pub Date : 2024-03-07 David Sánchez, Josep Ferrer, Estela Giménez, Ignacio Torres, Diego Carretero, María Jesús Alcaraz, María Jesús Castaño, David Navarro, Eliseo Albert
The significant proportion of asymptomatic patients and the scarcity of genotypic analysis of lymphogranuloma venereum (LGV), mainly among men who have sex with men (MSM), triggers a high incidence of underdiagnosed patients, highlighting the importance of determining the most appropriate strategy for LGV diagnosis, at both clinical and economical levels. We conducted L1-L3 serovar detection by molecular
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Lessons learned from implementation of four HIV self-testing (HIVST) distribution models in Zambia: applying the Consolidated Framework for Implementation Research to understand impact of contextual factors on implementation BMC Infect. Dis. (IF 3.7) Pub Date : 2024-03-06 Musonda Simwinga, Lwiindi Gwanu, Bernadette Hensen, Lucheka Sigande, Mwami Mainga, Thokozile Phiri, Eliphas Mwanza, Mutale Kabumbu, Chama Mulubwa, Lawrence Mwenge, Chiti Bwalya, Moses Kumwenda, Ellen Mubanga, Paul Mee, Cheryl C. Johnson, Elizabeth L. Corbett, Karin Hatzold, Melissa Neuman, Helen Ayles, Miriam Taegtmeyer
Although Zambia has integrated HIV-self-testing (HIVST) into its Human Immunodeficiency Virus (HIV) regulatory frameworks, few best practices to optimize the use of HIV self-testing to increase testing coverage have been documented. We conducted a prospective case study to understand contextual factors guiding implementation of four HIVST distribution models to inform scale-up in Zambia. We used the
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A dengue virus infection in Ethiopia: a systematic review and meta-analysis BMC Infect. Dis. (IF 3.7) Pub Date : 2024-03-06 Eshetu Nigussie, Daniel Atlaw, Getahun Negash, Habtamu Gezahegn, Girma Baressa, Alelign Tasew, Demisu Zembaba
Dengue is caused by a positive-stranded RNA virus called dengue virus, which is spread by Aedes mosquito species. It is a fast-growing acute febrile disease with potentially lethal consequences that is a global public health problem, mostly in tropical and subtropical countries. In Ethiopia, dengue fever is understudied, although the virus is still being transmitted and viral infection rates are rising
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Chronic disseminated candidiasis in a patient with acute leukemia - an illustrative case and brief review for clinicians BMC Infect. Dis. (IF 3.7) Pub Date : 2024-03-06 Allison Graeter, Dasom Lee, Guy Handley, Aliyah Baluch, Olga Klinkova
Chronic disseminated candidiasis (CDC) is a severe but rarely seen fungal infection presenting in patients with hematologic malignancies after a prolonged duration of neutropenia. A high index of suspicion is required to diagnose CDC as standard culture workup is often negative. While tissue biopsy is the gold standard of diagnosis, it is frequently avoided in patients with profound cytopenias and
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Socio-demographic determinants of the knowledge of Monkeypox Virus among the general public: a cross-sectional study in a Tertiary Care Center in Nepal BMC Infect. Dis. (IF 3.7) Pub Date : 2024-03-06 Santa Kumar Das, Abhinav Bhattarai, Kiran Paudel, Sandesh Bhusal, Sangam Shah, Sakchhyam Timsina, Aastha Subedi, Sandhya Niroula, Najim Z. Alshahrani, Sanjit Sah, Bijaya Kumar Padhi, Joshuan J. Barboza, Alfonso J. Rodriguez-Morales, Luis A. Salas-Matta, D. Katterine Bonilla-Aldana, Ranjit Sah
Monkeypox virus (MPXV) is the causative agent of monkeypox’s zoonotic infection and was declared a global emergency by the World Health Organization (WHO). Studies from different countries have shown insufficient knowledge among the general public on MPXV. This study aimed to assess the knowledge of the general public of Nepal on MPXV. Three hundred people were interviewed in person in October 2022
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Latent and incubation periods of Delta, BA.1, and BA.2 variant cases and associated factors: a cross-sectional study in China BMC Infect. Dis. (IF 3.7) Pub Date : 2024-03-06 Yu Li, Xinli Jiang, Yan Qiu, Feng Gao, Hualei Xin, Dan Li, Ying Qin, Zhongjie Li
The latent and incubation periods characterize the transmission of infectious viruses and are the basis for the development of outbreak prevention and control strategies. However, systematic studies on the latent period and associated factors with the incubation period for SAS-CoV-2 variants are still lacking. We inferred the two durations of Delta, BA.1, and BA.2 cases and analyzed the associated
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Sciatica caused by spinal epidural abscess as the initial clinical presentation of colon cancer: a rare case report and review of literature BMC Infect. Dis. (IF 3.7) Pub Date : 2024-03-06 Kuan-Yu Lu, Wei-En Tung, Chang-Jung Chiang, Yueh-Ying Hsieh, Chia-Hsien Chen, Mei-Hui Lee, Min-Hsuan Yen, Po-Wen Lu, Lien-Chen Wu
Colorectal cancer is one of the most frequently diagnosed forms of cancer, and it is associated with several common symptoms and signs such as rectal bleeding, altered bowel habits, abdominal pain, anemia, and unintentional weight loss. Sciatica, a debilitating condition in which the patient experiences paresthesia and pain in the dermatome of associated lumbosacral nerve roots or sciatic nerve distribution
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Tropheryma whipplei infection in the lung of a patient with long COVID: a case report BMC Infect. Dis. (IF 3.7) Pub Date : 2024-03-06 Wenjing Ruan, Jing Xu, Fan Yang, Xiaohong Wu, Kejing Ying
Immune dysregulation in individuals with long COVID has been detected. Differential diagnosis of diffuse infiltration on chest CT in long COVID is challenging. A 62-year-old man presented with a 10-month history of dyspnea after COVID-19 infection. Dyspnea became worse in the one month preceding presentation. The chest CT showed multifocal, subpleural, bilateral opacities due to long-COVID, and infiltration
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Letter to the editor regarding - pleural effusion caused by Trichinella spiralis infection: two case reports BMC Infect. Dis. (IF 3.7) Pub Date : 2024-03-06 Jean Dupouy-Camet, Fabien Vaylet, Fabrizio Bruschi
We read with interest the paper entitled “Pleural effusion caused by Trichinella spiralis infection: two case reports”, published by Pan and colleagues in a recent issue of your journal [1]. In brief, the authors described two cases of exudative pleurisy with a high level of mononuclear cells and a positive Trichinella serology. As a matter of fact, pleurisy is not a frequent occurrence during trichinellosis
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Demographic characteristics and mental health condition of Tehran Municipality employees during the COVID-19 pandemic BMC Infect. Dis. (IF 3.7) Pub Date : 2024-03-06 Elham Kalhori, Nahid Khodakarami, Mostafa Hamdieh, Roya Gholami, Sareh Dashti
Coronavirus disease 2019 (COVID-19) has become a global health issue with various effects on the physical and mental state of the societies. The aim of this study was to identify the demographic characteristics and mental health condition of Tehran Municipality employees during the COVID-19 pandemic. This cross-sectional study was performed on Tehran Municipality employees in 2020–2021. Participants
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Seroprevalence and risk factors of HBV, HCV and HIV among hemodialysis patients: a multicenter cross-sectional study from Damascus Syria BMC Infect. Dis. (IF 3.7) Pub Date : 2024-03-06 Jehan Altinawe, Muhammad Eid Akkawi, Nihad Kharrat Helu, Qusai Hassan, Abdul-Hakim Nattouf
The aim of this study is to determine the prevalence rates of hepatitis B virus (HBV), hepatitis C virus (HCV), and human immunodeficiency virus (HIV) infections among hemodialysis (HD) patients as well as to identify associated risk factors. A multicenter cross-sectional study involved patients who had been on HD for at least three months. The study was conducted at five HD centers in Damascus, Syria
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Nontuberculous mycobacteria testing and culture positivity in the United States BMC Infect. Dis. (IF 3.7) Pub Date : 2024-03-06 Julia E. Marshall, Rachel A. Mercaldo, Ettie M. Lipner, D. Rebecca Prevots
Nontuberculous mycobacteria (NTM) are environmental bacteria which may cause chronic lung disease. The prevalence of NTM pulmonary infection and disease has been increasing in the United States and globally. The predominant clinically relevant species of NTM in the United States are Mycobacterium avium complex (MAC) species and Mycobacterium abscessus. With the development of rapid species identification
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Hepatitis C (HCV) prevalence in citizens of the Métis Nation of Ontario BMC Infect. Dis. (IF 3.7) Pub Date : 2024-03-06 Noel Tsui, Gabriel B. Tjong, Abigail J. Simms, Sarah A. Edwards, Shelley Cripps
Hepatitis C virus (HCV) infection is a major global concern, with Indigenous Peoples bearing the highest burden. Previous studies exploring HCV prevalence within Indigenous populations have predominantly used a pan-Indigenous approach, consequently resulting in limited availability of Métis-specific HCV data. The Métis are one of the three recognized groups of Indigenous Peoples in Canada with a distinct
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Diverse proinflammatory response in pharyngeal epithelial cells upon interaction with Neisseria meningitidis carriage and invasive isolates BMC Infect. Dis. (IF 3.7) Pub Date : 2024-03-06 Alexander Persson, Therese Koivula, Susanne Jacobsson, Bianca Stenmark
Invasive meningococcal disease (IMD), including sepsis and meningitis, can develop when Neisseria meningitidis bacteria breach the barrier and gain access to the circulation. While IMD is a rare outcome of bacterial exposure, colonization of the oropharynx is present in approximately 10% of the human population. This asymptomatic carriage can be long or short term, and it is unknown which determining
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Polymicrobial bloodstream infections per se do not increase mortality compared to monomicrobial bloodstream infections in sepsis patients: a Korean nationwide sepsis cohort study BMC Infect. Dis. (IF 3.7) Pub Date : 2024-03-05 Su Yeon Lee, Mi Hyeon Park, Dong Kyu Oh, Chae-Man Lim
There is limited information about the outcomes of polymicrobial bloodstream infections in patients with sepsis. We aimed to investigate outcomes of polymicrobial bloodstream infections compared to monomicrobial bloodstream infections. This study used data from the Korean Sepsis Alliance Registry, a nationwide database of prospective observational sepsis cohort. Adult sepsis patients with bloodstream
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Diagnosis of multiple tuberculous muscle abscesses in a patient with systemic lupus erythematosus by metagenomic next-generation sequencing- a case report and literature review BMC Infect. Dis. (IF 3.7) Pub Date : 2024-03-04 Liu Wentao, Xie Shuxia, Zhu Guoxing, Chen Qiaoping, Chen Peiran, Wu Angela, Li Meirong, Yin Songchao, Feng Peiying
Early diagnosis of muscular tuberculosis (TB) without coexistent active skeletal involvement is often challenging because the disease is very rare and its clinical manifestation is nonspecific and misleading. To raise the awareness and emphasize early diagnosis of muscular TB, we present a case of multiple tuberculous muscle abscesses in a systemic lupus erythematosus (SLE) female, but without pulmonary
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Letter to the editor regarding the case report: unregulated medication use and complications: is self-medication a common problem with anti-tuberculous therapy (ATT)? Role for patient education BMC Infect. Dis. (IF 3.7) Pub Date : 2024-03-04 Vijay Alexander, Jasper Rathinam J., John Titus George, Jackwin Sam Paul
To the Editor, We read with great interest the case report titled ‘unregulated medication use and complications: a case study of prolonged self-treated tuberculosis in Nepal’ [1]. The authors describe a middle-aged gentleman diagnosed with tuberculosis once, later continues to self-medicate for years without seeking medical attention. The case in discussion is unusual for many reasons, and raises multiple
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Persistent high sepsis-induced coagulopathy and sequential organ failure assessment scores can predict the 28-day mortality of patients with sepsis: A prospective study BMC Infect. Dis. (IF 3.7) Pub Date : 2024-03-04 Junyu Li, Huizhen Liu, Na Wang, Fengrong Wang, Na Shang, Shubin Guo, Guodong Wang
The performance of the sepsis-induced coagulopathy (SIC) and sequential organ failure assessment (SOFA) scores in predicting the prognoses of patients with sepsis has been validated. This study aimed to investigate the time course of SIC and SOFA scores and their association with outcomes in patients with sepsis. This prospective study enrolled 209 patients with sepsis admitted to the emergency department
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The RdRp genotyping of SARS-CoV-2 isolated from patients with different clinical spectrum of COVID-19 BMC Infect. Dis. (IF 3.7) Pub Date : 2024-03-04 Michał Majchrzak, Łukasz Madej, Małgorzata Łysek-Gładysińska, Dorota Zarębska-Michaluk, Katarzyna Zegadło, Anna Dziuba, Katarzyna Nogal-Nowak, Wioleta Kondziołka, Iwona Sufin, Mieczysława Myszona-Tarnowska, Mateusz Jaśkowski, Mateusz Kędzierski, Jadwiga Maciukajć, Jarosław Matykiewicz, Stanisław Głuszek, Wioletta Adamus-Białek
The evolution of SARS-CoV-2 has been observed from the very beginning of the fight against COVID-19, some mutations are indicators of potentially dangerous variants of the virus. However, there is no clear association between the genetic variants of SARS-CoV-2 and the severity of COVID-19. We aimed to analyze the genetic variability of RdRp in correlation with different courses of COVID-19. The prospective
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Causal effects of gut microbiome on HIV infection: a two-sample mendelian randomization analysis BMC Infect. Dis. (IF 3.7) Pub Date : 2024-03-04 Kangjie Li, Cong Zhang, Jielian Deng, Haijiao Zeng, Yuan Zhang, Guichuan Lai, Xiaoni Zhong, Biao Xie
The causal association between gut microbiome and HIV infection remains to be elucidated. We conducted a two-sample mendelian randomization analysis to estimate the causality between gut microbiome and HIV infection. Publicly released genome-wide association studies summary data were collected to perform the mendelian analysis. The GWAS summary data of gut microbiome was retrieved from the MiBioGen
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Application of metagenomic next-generation sequencing in the clinical diagnosis of infectious diseases after allo-HSCT: a single-center analysis BMC Infect. Dis. (IF 3.7) Pub Date : 2024-03-04 Hailong Yuan, Xiaolu Ma, Jianli Xu, Peng Han, Guanhua Rao, Gang Chen, Kaile Zhang, Ruixue Yang, Chuixia Han, Ming Jiang
We investigated the value of metagenomic next-generation sequencing (mNGS) in diagnosing infectious diseases in patients receiving allogeneic hematopoietic stem cell transplantation (allo-HSCT). Fifty-four patients who had fever following allo-HSCT from October 2019 to February 2022 were enrolled. Conventional microbiological tests (CMTs) and mNGS, along with imaging and clinical manifestations, were
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Diagnostic accuracy of procalcitonin in adult non-neutropenic cancer patients with suspected infection: a systematic review and meta-analysis BMC Infect. Dis. (IF 3.7) Pub Date : 2024-03-04 Yi-Chih Lee, Hsin-Tzu Yeh, Sz-Wei Lu, Yi-Chun Tsai, Yu-Chen Tsai, Chieh-Ching Yen
Procalcitonin (PCT) has garnered attention as a potential diagnostic biomarker for infection in cancer patients. We performed a systematic review and meta-analysis to evaluate the diagnostic accuracy of procalcitonin (PCT) and to compare it with C‐reactive protein (CRP) in adult non-neutropenic cancer patients with suspected infection. A systematic literature search was performed in MEDLINE, EMBASE
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Independent clinic-based evaluation of point-of-care testing for the screening of Chlamydia trachomatis, Neisseria gonorrhoea and Trichomonas vaginalis in women-at-risk in Australia, Guatemala, Morocco, and South Africa BMC Infect. Dis. (IF 3.7) Pub Date : 2024-03-04 Mark Shephard, Susan Matthews, Ranmini Kularatne, Kelly Andrewartha, Karel Blondeel, Christian Alvarez, Elsy Camey, Amina Hançali, Etienne Müller, Aurelie Haw, Hicham Oumzil, Daniel Golparian, Dorian E Ramirez, James Kiarie, Firdavs Kurbonov, Massimo Mirandola, Rosanna W Peeling, Ronaldo Silva, Soe Soe Thwin, Magnus Unemo, Igor Toskin
In 2018, the World Health Organization commenced a multi-country validation study of the Cepheid GeneXpert for a range of molecular-based point-of-care (POC) tests in primary care settings. One study arm focused on the evaluation of POC tests for screening ‘women at risk’ for chlamydia (CT), gonorrhoea (NG) and trichomonas (TV) in four countries – Australia, Guatemala, Morocco and South Africa. Study
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Comparison of therapeutic effects between big-bubble deep anterior lamellar keratoplasty and penetrating keratoplasty for medically unresponsive Acanthamoeba keratitis BMC Infect. Dis. (IF 3.7) Pub Date : 2024-03-04 Xiaolin Qi, Huilin Mao, Jinhui Liu, Yanling Dong, Man Du, Ting Liu, Ting Zhang, Xiuhai Lu, Hua Gao
To compare the outcomes of big-bubble deep anterior lamellar keratoplasty (BB-DALK) and penetrating keratoplasty (PKP) in the management of medically unresponsive Acanthamoeba keratitis (AK). This retrospective study included 27 eyes of BB-DALK and 24 eyes of PKP from a tertiary ophthalmology care centre. Glucocorticoid eye drops were subsequently added to the treatment plan 2 months postoperatively
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An elevated level of interleukin-17A in a Senegalese malaria cohort is associated with rs8193038 IL-17A genetic variant BMC Infect. Dis. (IF 3.7) Pub Date : 2024-03-04 Fatou Thiam, Gora Diop, Cedric Coulonges, Celine Derbois, Alassane Thiam, Abou Abdallah Malick Diouara, Mame Ndew Mbaye, Mamadou Diop, Cheikh Momar Nguer, Yakhya Dieye, Babacar Mbengue, Jean-Francois Zagury, Jean-Francois Deleuze, Alioune Dieye
Malaria infection is a multifactorial disease partly modulated by host immuno-genetic factors. Recent evidence has demonstrated the importance of Interleukin-17 family proinflammatory cytokines and their genetic variants in host immunity. However, limited knowledge exists about their role in parasitic infections such as malaria. We aimed to investigate IL-17A serum levels in patients with severe and
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Antimicrobial resistance patterns, virulence genes, and biofilm formation in enterococci strains collected from different sources BMC Infect. Dis. (IF 3.7) Pub Date : 2024-03-04 Maryam Ghazvinian, Saba Asgharzadeh Marghmalek, Mehrdad Gholami, Sanaz Amir Gholami, Elham Amiri, Hamid Reza Goli
Currently, antibiotic-resistant strains of Enterococcus are considered to be one of the critical health challenges globally. This study aimed to investigate the antibiotic susceptibility pattern, biofilm formation capacity, and virulence genes of enterococci isolated from different sources. In this cross-sectional study, environmental and fecal samples were collected from the hospital environment,
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Time trends in herpesvirus seroepidemiology among Swedish adults BMC Infect. Dis. (IF 3.7) Pub Date : 2024-03-02 Jan Olsson, Sema Nourmohammadi, Emma Honkala, Anders Johansson, Göran Hallmans, Bodil Weidung, Hugo Lövheim, Fredrik Elgh
Human herpesviruses are widespread among the human population. The infections often occur unnoticed, but severe disease as well as long-term sequelae are part of the symptom spectrum. The prevalence varies among subpopulations and with time. The aim of this study was to describe the seroprevalence of Immunoglobulin G against Herpes simplex 1, Herpes simplex 2, Epstein-Barr virus and Cytomegalovirus
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Correction: Paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome in initiating ART among HIV-Infected patients in China-risk factors and management BMC Infect. Dis. (IF 3.7) Pub Date : 2024-03-01 Honghong Yang, Qian Liu, Yushan Wu, Kun He, Qin Zeng, Min Liu
Correction: BMC Infect Dis 24, 5 (2024) https://doi.org/10.1186/s12879-023-08897-3 Following publication of the original article [1], we have been notified that Fig. 2 was showing one unnecessary parameter (fever). Originally published Fig. 2: Corrected Fig. 2: Fig. 2 Associations between pre-ART clinical and laboratory characteristics with subsequent paradoxical TB-IRIS events. The variables that
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Efficacy of povidone-iodine nasal rinse and mouth wash in COVID-19 management: a prospective, randomized pilot clinical trial (povidone-iodine in COVID-19 management) BMC Infect. Dis. (IF 3.7) Pub Date : 2024-03-01 Saad Alsaleh, Ahmed Alhussien, Abduljabbar Alyamani, Fahad Alhussain, Ali Alhijji, Khalifa Binkhamis, Anas Khan, Amin Javer, Fatimah S. Alshahrani
To assess the efficacy of 0.23% povidone-iodine (PVP-I) nasal rinses and mouth washes on detectability of the coronavirus disease 2019 (COVID-19) virus and cycle threshold (Ct) values in nasopharyngeal swabs. This was an open-label, prospective, randomized, placebo-controlled clinical trial. The study was conducted in King Saud University Medical City, Riyadh, Saudi Arabia, from August 2021 to July
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Polymorphisms of IFN signaling genes and FOXP4 influence the severity of COVID-19 BMC Infect. Dis. (IF 3.7) Pub Date : 2024-03-01 Feng Zhang, Pingping Zhou, Liangliang Wang, Xinzhong Liao, Xuejie Liu, Changwen Ke, Simin Wen, Yuelong Shu
The clinical manifestations of COVID-19 range from asymptomatic, mild to moderate, severe, and critical disease. Host genetic variants were recognized to affect the disease severity. However, the genetic landscape differs among various populations. Therefore, we explored the variants associated with COVID-19 severity in the Guangdong population. A total of 314 subjects were selected, of which the severe
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The origin, dissemination, and molecular networks of HIV-1 CRF65_cpx strain in Hainan Island, China BMC Infect. Dis. (IF 3.7) Pub Date : 2024-03-01 Dee Yu, Kaokao Zhu, Mu Li, Fei Zhang, Yuan Yang, Chunyun Lu, Shanmei Zhong, Cai Qin, Yanan Lan, Jipeng Yu, Jindong Ding Petersen, Junjun Jiang, Hao Liang, Li Ye, Bingyu Liang
HIV-1 CRF65_cpx strain carries drug-resistant mutations, which raises concerns about its potential for causing virologic failure. The CRF65_cpx ranks as the fourth most prevalent on Hainan Island, China. However, the origin and molecular epidemiology of CRF65_cpx strains in this area remain unclear. This study aims to estimate the spatial origins and dissemination patterns of HIV-1 CRF65_cpx in this
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Costs of distributing HIV self-testing kits in Eswatini through community and workplace models BMC Infect. Dis. (IF 3.7) Pub Date : 2024-02-29 Kathleen McGee, Marc d’Elbée, Ralitza Dekova, Linda A. Sande, Lenhle Dube, Sanele Masuku, Makhosazana Dlamini, Collin Mangenah, Lawrence Mwenge, Cheryl Johnson, Karin Hatzold, Melissa Neuman, Gesine Meyer-Rath, Fern Terris-Prestholt
This study evaluates the implementation and running costs of an HIV self-testing (HIVST) distribution program in Eswatini. HIVST kits were delivered through community-based and workplace models using primary and secondary distribution. Primary clients could self-test onsite or offsite. This study presents total running economic costs of kit distribution per model between April 2019 and March 2020,