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Innate Immune Response-Mediated Inflammation in Viral Pneumonia J. Pediatr. Infect. Dis. (IF 0.3) Pub Date : 2024-03-11 Weiwei Ni, Xin Wei, Rui Wu
Objective This study aims to investigate the intricate interactions between viral infections, specifically within the context of community-acquired pneumonia. We seek to shed light on the underestimation of viral pneumonia cases, utilizing advancements in molecular diagnostic testing. Methods The investigation involves a comprehensive review of existing literature to explore the prevalence and impact
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Late Respiratory and Laboratory Findings in Children with a History of Symptomatic and Asymptomatic SARS-CoV-2 Infection J. Pediatr. Infect. Dis. (IF 0.3) Pub Date : 2024-03-04 Ayşe Gul Yucel, Ugur Cem Mete, Fatma Duksal
Objective Symptoms due to coronavirus disease 2019 (COVID-19) may persist or new symptoms may appear later. It was aimed to investigate the relationships between late respiratory system findings, allergen sensitivity, and laboratory findings in children with asymptomatic or symptomatic COVID-19 history. Methods The study was conducted in tertiary hospital prospectively between April and July 2021.
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Periostin Modulating Mycoplasma pneumoniae Pneumonia in Children Related to Th17 Cell Function J. Pediatr. Infect. Dis. (IF 0.3) Pub Date : 2024-03-04
Objective Mycoplasma pneumoniae pneumonia (MPP) is recognized as a significant respiratory tract infection in children. Periostin associates with airway remodeling, and the T helper 17 (Th17) cells play a crucial role against M. pneumoniae infection. This study investigates the effect of periostin in Th17 cells and the associated mechanism in MPP. Methods The study investigated the role of periostin
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The Relationship between Soluble Angiotensin-Converting Enzyme Level and Coronavirus Disease 2019 in Children: A Prospective Cohort Study J. Pediatr. Infect. Dis. (IF 0.3) Pub Date : 2024-03-04 Hacer Efnan Melek Arsoy, Bahri Elmas, Ayşe Tarim, Pınar Dervişoğlu Çavdar, Mehmet Fatih Orhan, Hayrullah Yazar
Objective Our objective was to investigate soluble angiotensin-converting enzyme (sACE) levels in pediatric patients with coronavirus disease 2019 (COVID-19) and to identify factors associated with the occurrence and severity of pediatric COVID-19. Methods This was a prospective cohort study conducted between April 2020 and July 2020. The study population consisted of 143 children (between 1 month
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Challenges in Diagnosis and Treatment of Neonatal Ventriculitis: A Case Report and Systematic Review of Difficult-to-Treat Central Nervous System Infection Resistant to Conventional Therapy J. Pediatr. Infect. Dis. (IF 0.3) Pub Date : 2024-02-02 Hakan Ongun, Zeynep Kihtir, Nurten Ozkan Zarif, Ozlem Koyuncu Ozyurt, Tugce Tural Kara, Kiymet Celik, Sema Arayici
Objective Ventriculitis is an example of the increasing global trend in difficult-to-treat infections in neonates caused by pathogens resistant to conventional therapies. This article describes the first use of intravenous and intraventricular tigecycline to treat ventriculitis caused by vancomycin-resistant enterococci in a preterm neonate and systematically review the literature on challenges posed
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Effects of EPs 7630 on Illness Absence from Childcare or School due to Acute Bronchitis—A Meta-analysis J. Pediatr. Infect. Dis. (IF 0.3) Pub Date : 2024-01-12
Objective In the pediatric population, acute bronchitis (AB) is a leading cause of illness absence from childcare, school, or apprenticeship. We report a meta-analysis of double-blind, randomized trials with children and adolescents with AB (aged 1–18 years), who were treated with Pelargonium extract EPs 7630 or placebo for 7 days. Methods The average number of days absent from childcare, school, or
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Rare Cause of Soft Tissue Infection: Shewanella algae J. Pediatr. Infect. Dis. (IF 0.3) Pub Date : 2024-01-12 Ezgi Yılık, Ayşe Hümeyra Akgül, Mustafa Gençeli, Özge Metin Akcan, Seda Nur Arazi Kan, Metin Doğan
Shewanella algae is a common microorganism in nature, but a rare pathogen in humans. It is a causative agent of skin and soft tissue infections, especially in patients with skin ulcers or trauma. S. algae can enter the body through the eyes, ears, gastrointestinal tract, or respiratory tract. Immunocompromised individuals are at increased risk of developing bacteremia and sepsis from the infection
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Comparison of Clinical, Laboratory Parameters, and Outcome of COVID-19-Positive and Negative Neonates Delivered from COVID-19-Positive Mothers J. Pediatr. Infect. Dis. (IF 0.3) Pub Date : 2023-12-29 Preeti Singh, Ankur Kumar, Anita Mehta, Mudit Chauhan
Objective Severe acute respiratory syndrome coronavirus 2 is a highly contagious respiratory viral infection that affects all individuals, although neonates are considered to be the most susceptible populations; therefore, this study was conducted to evaluate the clinical outcome and association between coronavirus disease 2019 (COVID-19)-positive mothers and newborns. Methods This cross-sectional
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Suspected Myocarditis after mRNA COVID-19 Vaccination among South Korean Adolescents J. Pediatr. Infect. Dis. (IF 0.3) Pub Date : 2023-12-29 Mi Jin Kim, Jin Hee Kim, Hyun Ok Jun, Kyung Min Kim, Min Sub Jeung, Jun Sung Park
Objective Since vaccination for coronavirus disease 2019 (COVID-19) has been initiated, rare cases of COVID-19 mRNA vaccination-associated myocarditis (VAM) have been reported worldwide. This study aimed to report the short-term outcomes and the clinical presentation of VAM in South Korean adolescents. Methods In this prospective multicenter study across five tertiary hospitals in South Korea, patients
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Is Congenital Syphilis Still a Problem?—A 20-Year Retrospective Study from a Northern Portuguese Level II Hospital J. Pediatr. Infect. Dis. (IF 0.3) Pub Date : 2023-12-29 Ana Sofia Figueiredo, Carolina Quintela, Mafalda Cascais, Juan Calviño, Marisa Sousa, António Pereira, Isabel Soares
Objective The incidence of syphilis and congenital syphilis has increased in recent years according to European and United States of America official data: indeed, 2019 was the second consecutive year when the number of reported cases has increased. Syphilis is a venereal disease caused by a spirochete, Treponema pallidum. Congenital syphilis is a consequence of maternal T. palidum transmission to
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Identification of a Novel lncRNA in Diagnosis of Sepsis-Induced Cardiomyopathy Using a Comprehensive Analysis of lncRNA-mRNA Network J. Pediatr. Infect. Dis. (IF 0.3) Pub Date : 2023-12-11
Objective Long noncoding RNAs (lncRNAs) have been implicated in various biological processes, particularly in the regulation of inflammatory responses and myocardial injuries. Notably, the role of lncRNAs in sepsis-induced cardiomyopathy (SIC) has been highlighted. However, a comprehensive analysis investigating the specific circulating lncRNAs associated with SIC has yet to be conducted. Therefore
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Association between SARS-CoV-2 Seropositivity and Severity of Out-of-Hospital Acute Ischemic Stroke Following Asymptomatic/Mild COVID-19 in Children J. Pediatr. Infect. Dis. (IF 0.3) Pub Date : 2023-12-11 Elsayed Abdelkreem, Ekram A. Mahmoud, Nesma A. Mohamed, Ghada A. B. Abd-Elrehim, Eman M. Fahmy
Objective This article investigates the frequency of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) seropositivity and its association with the severity of new-onset acute ischemic stroke (AIS) among previously healthy children with asymptomatic/mild coronavirus disease 2019 (COVID-19). Methods A case–control study that included children < 18 years with out-of-hospital AIS of undetermined
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Respiratory Syncytial Virus and Parainfluenza Virus: Characterizing Distinct Clinical Profiles and How They Shift with Bacterial Coinfection J. Pediatr. Infect. Dis. (IF 0.3) Pub Date : 2023-11-22 Bo Nie, Ying Cheng, Hong-bo Hu
Objective The objectives are to characterize the distinct clinical profiles of respiratory syncytial virus (RSV) and parainfluenza virus (PIV) infections and how these profiles shift with the addition of bacterial coinfections. Methods This retrospective study analyzed data from more than 1,000 hospitalized children to compare RSV monoinfection with PIV monoinfection, as well as RSV/PIV coinfection
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Epidemiological and Genetic Characteristics of Mycoplasma pneumoniae Pneumonia after the Outbreak of COVID-19 J. Pediatr. Infect. Dis. (IF 0.3) Pub Date : 2023-11-06 Lin Li, Bing-han Wang, Wei Li
Objective Mycoplasma pneumoniae pneumonia (MPP) accounts for a major part of community-acquired pneumonia in children, and we performed this study to investigate the epidemiological and genetic characteristics of MPP after the outbreak of COVID-19. Methods A total of 15,538 throat swab samples were collected from inpatients with respiratory tract infections from January 2021 to December 2021. All specimens
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Clinical Features and Determinants of Coronary Artery Dilatation in Pediatric Patients with Complete and Incomplete Kawasaki Disease: A Single-Center Experience Over 15 Years in Hubei, China J. Pediatr. Infect. Dis. (IF 0.3) Pub Date : 2023-10-29 You-ping Deng, Yu-xing Zan, Xia Wang, Qiu Xia, Pin Liu, Hai-rong Xiong, Dong-chi Zhao
Objective This study is aimed to elucidate age-associated clinical and echocardiography-defined coronary artery (CA) abnormalities features and to identify independent determinants of CA dilatation in pediatric patients with complete Kawasaki disease (cKD) and incomplete KD (iKD) over 15 years in a tertiary hospital in China. Methods This study comprised 241 patients with KD hospitalized in the pediatric
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Frequency of Lymphopenia in Infants with COVID-19; Vaccination Dilemma J. Pediatr. Infect. Dis. (IF 0.3) Pub Date : 2023-10-29 Neslihan Mete Atasever, Elif Dede, Asuman Demirbuğa, Behiye Benaygül Kaçmaz, Gonca Keskindemirci, Ayper Somer, Selda Hançerli Törün
Objective Although coronavirus disease 2019 (COVID-19) is mainly a respiratory system disease, many hematological abnormalities have been reported. Due to the application of primary immunization in infancy, our study aimed to examine the relationship between lymphopenia frequency and duration of lymphopenia in infants with COVID-19. Methods The files of infants hospitalized with the diagnosis of COVID-19
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A Retrospective Study of the Association between Respiratory Tract Viral PCR Panel Results and Clinical Outcomes in Children with Cancer and Febrile Neutropenia and Review of the Literature J. Pediatr. Infect. Dis. (IF 0.3) Pub Date : 2023-10-16 Özlem Terzi, Nuran Karabulut, Ezgi Paslı Uysalol, Ayşe Gonca Kaçar, Hüseyin Avni Solgun, Saide Ertürk, Halil İbrahim Şimşek, Cengiz Bayram, Ali Ayçiçek
Objective The role of respiratory viral pathogens (RVPs) in children with cancer having febrile neutropenic (FEN) episodes has not been well studied. The objectives of this study were to investigate the prevalence and clinical outcomes of RVP in this group. Methods Pediatric patients with cancer and an episode of FEN, presenting between March 2021 and March 2022 were included. All data were retrospectively
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Emergence of Drug-Resistant Pathogens in a Neonatal Intensive Care Unit J. Pediatr. Infect. Dis. (IF 0.3) Pub Date : 2023-10-16 Aydın Aydınlı, Deniz Sertel Şelale, Ayşe Demet Kaya
Objective Neonatal bloodstream infections (BSIs) due to drug-resistant pathogens are a major cause of neonatal morbidity and mortality. Unfortunately, data regarding the pathogens and their resistance profile are limited in developing countries. The aim of this study was to determine the bacteriological profile and antimicrobial susceptibility patterns in neonatal BSI at a university hospital in Türkiye
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Ventilation-Associated Pneumonia in Pediatric Intensive Care in Saudi Arabia: A Two-Year Retrospective Study of Incidence, Risk Factors, and Outcome J. Pediatr. Infect. Dis. (IF 0.3) Pub Date : 2023-09-25 Khouloud Abdulrhman Al-Sofyani
Objective This article assesses the incidence, risk factors, and outcomes of ventilator-associated pneumonia (VAP) in pediatric intensive care unit (PICU) patients in western Saudi Arabia. Methods A retrospective cohort study enrolled 375 children admitted to the PICU of King Abdulaziz University Hospital, Jeddah, Saudi Arabia. The study data involves clinical assessment of pediatric patients admitted
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Association between MIS-C and Functional Gastrointestinal Disorders in Children: A Cross-Sectional Study J. Pediatr. Infect. Dis. (IF 0.3) Pub Date : 2023-09-22 Hatice Uygun, Sibel Yavuz, Tarık Şahin, Nurettin Erdem, Mehmet Turgut
Objective Multisystem inflammatory syndrome in children (MIS-C) is a serious complication of coronavirus disease 2019 which causes a hyperinflammatory syndrome that can affect all organ systems. Functional gastrointestinal disorders (FGIDs) are a heterogeneous disease spectrum with unclear etiology. Today, it is known that low-grade inflammation can cause FGIDs. Our aim in this study was to investigate
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Invasive Streptococcus pyogenes: A Short Literature Review J. Pediatr. Infect. Dis. (IF 0.3) Pub Date : 2023-08-31 Yeliz Tanrıverdi Çaycı, Mustafa Altındiş
Objective Streptococcus pyogenes also called Group A streptococci (GAS) is an important pathogen known since past years and infects millions of people around the world every year and can cause death. Although it often causes pharyngitis and skin infections, it can also spread to the bloodstream and cause invasive GAS (iGAS) infections. In this review, studies on the epidemiology of GAS and iGAS and
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Drug Resistance Analysis of Pathogens Isolated from Pediatric Patients in Mexico J. Pediatr. Infect. Dis. (IF 0.3) Pub Date : 2023-08-14 Flora Cruz-López, Joaquín Rincón-Zuno, Rayo Morfin-Otero, Eduardo Rodríguez-Noriega, Reyna Edith Corte-Rojas, José Manuel Feliciano-Guzmán, Mariana Gil-Veloz, Lorena Rodríguez-Muñoz, Elena Victoria Choy-Chang, Carlos Miguel Cetina-Umaña, Laura Karina Avilés-Benítez, Adrián Martínez-Meléndez, Esaú López-Jácome, Jesús Silva-Sánchez, Enrique Bolado-Martínez, Maribel López-García, Juan de Dios Castañeda-Duarte
Objective To analyze the resistance to antimicrobials in clinical isolates from pediatric patients in Mexico. Methods Susceptibility data from relevant specimens were collected in the pediatric population over 6 months from 25 centers from 17 states of Mexico and analyzed using the WHONET 5.6 software. Data were stratified into three age groups: younger than 2 years, 2 to 6 years, and 6 to 18 years
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Outbreak of Gastrointestinal Infections Caused by Yersinia enterocolitica in Children, Medellín, Colombia J. Pediatr. Infect. Dis. (IF 0.3) Pub Date : 2023-08-11 Julián C. Galvis, Claudia Beltrán, Elizabeth Sierra, Aleyda M. Montaño, Faiver Ramírez, Pablo Villa, Alejandro Diaz, Carlos Robledo, Jaime Robledo
Objective In this study, we describe the clinical and epidemiological characteristics of a cluster of children with acute gastrointestinal (GI) infection caused by Yersinia enterocolitica in Medellín, Colombia. Methods A retrospective descriptive observational study was performed with the information recorded in clinical charts of GI infection cases caused by Y. enterocolitica in pediatric population
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Pediatric Crimean–Congo Hemorrhagic Fever Experience during the COVID-19 Pandemic J. Pediatr. Infect. Dis. (IF 0.3) Pub Date : 2023-08-10 Zeynep Savaş Şen, Gönül Tanir, Meltem Polat, Yasemin Coşgun, Rumeysa Yalcinkaya, Suna Özdem, Rüveyda Gümüşer Cinni, Ayşe Kaman, Türkan Aydin Teke, Fatma Nur Öz
Objective Crimean–Congo hemorrhagic fever (CCHF) is a zoonotic disease that is mainly transmitted by tick bites. During the COVID-19 pandemic, a change of notifications has been reported for most infectious diseases. We aimed to compare CCHF in pediatric patients during the COVID-19 pandemic and before the pandemic period with demographic, clinical, and laboratory features. Methods Overall, 18 CCHF
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Life-Threatening Streptococcal Soft Tissue Infections in Children with Chickenpox: A Post-COVID-19 Case Series J. Pediatr. Infect. Dis. (IF 0.3) Pub Date : 2023-08-08 Iona McKechnie, Ankit Mishra, Jana Torres-Grau, Jonathan Cohen, Simon Filson
Objective Children with chickenpox complicated by soft tissue infections can become critically unwell. We investigated cases that were referred to our center to examine the role of medical and surgical management in their care. Methods Children presenting with severe soft tissue infections (SSTIs) associated with varicella infections to a tertiary children's hospital in London serving the South East
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Evaluation of SARS-CoV-2 Mother-to-Child Vertical Transmission: Prospective and Observational Study J. Pediatr. Infect. Dis. (IF 0.3) Pub Date : 2023-08-08 Alper Divarci, Ali Bulbul, Evrim Kiray Bas, Gulen Hurkal Yigitler, Alev Aydin, Hasan Avsar, Emel Celebi Congur, Hasan Sinan Uslu, Ebru Turkoglu Unal
Objective The COVID-19 pandemic was declared a pandemic and a global health emergency by the World Health Organization (WHO) on March 11, 2020. COVID-19 infection is the most common cause of life-threatening acute respiratory tract infection in adults and older people but more mildly in the childhood age group. While the pandemic continues, there is no clear information about the vertical transmission
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Hematological and Extra-Hematological Manifestations of Parvovirus B19 Disease J. Pediatr. Infect. Dis. (IF 0.3) Pub Date : 2023-07-31 Cengiz Zeybek, Ahmet Bolat, Orhan Gürsel, İbrahim Eker, Ahmet Emin Kürekçi
Objective Parvovirus B19 (PVB19) is a virus that can present with many hematological and extra-hematological findings. Its prognosis is relatively good in immunocompetent patients, but severe disease may develop in immunocompromised patients. We retrospectively reviewed a series of children who presented with PVB19 during a 6-year period at our institution. Methods Nine children with positive polymerase
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Antibiofilm Activity of Different Washing Solutions against Biofilms in Cystic Fibrosis Patients' Nasal Cavities J. Pediatr. Infect. Dis. (IF 0.3) Pub Date : 2023-07-24 Gökhan Tüzemen, Nazmiye Ülkü Tüzemen, Perihan Erkan Alkan, Cüneyt Özakın
Objective Bacterial biofilm formation is a multistep process involving bacterial adhesion to inorganic or mucosal surfaces. We aimed to identify Staphylococcus aureus and Pseudomonas aeruginosa strains colonizing the respiratory tracts of cystic fibrosis (CF) patients and to gauge the antibiofilm potential of streptomycin and ozone solutions against them. Methods Bacteria were obtained from CF patients'
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Frequency and Reasons for Vaccination Failure against Measles among Pediatric Cases at a Tertiary Care Hospital of Karachi J. Pediatr. Infect. Dis. (IF 0.3) Pub Date : 2023-07-24 Ammarah Jamal, Sharmeen Nasir, Faiza Hayee, Yousuf Yahya
Objective A nationwide measles–rubella (MR) vaccination campaign was executed in Pakistan in November 2021. Despite that, there was a persistence of new measles cases. Thus, we designed this study to determine the measles vaccination status in patients with measles and to determine the reasons of missed vaccination during the campaign. Methods We reviewed medical records of measles patients >1 month
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An Evaluation of the Risk Factors and Respiratory Function Test Change of Children with Cystic Fibrosis Who Contracted COVID-19 Infection J. Pediatr. Infect. Dis. (IF 0.3) Pub Date : 2023-06-12 Mehmet Mustafa Özaslan, Handan Duman Şenol, Meral Barlık, Fevziye Çoksuer, Bahar Girgin Dindar, Esen Demir, Figen Gülen
Objective Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was declared a global pandemic in March 2020, with millions of infected cases worldwide. Although the course is usually mild in the pediatric age group, there are unknown factors in patients with chronic lung diseases. The aim of this study was to determine the demographic characteristics
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The Effect of the COVID-19 Pandemic on the Frequency and Course of Inflammatory Bowel Disease in Children J. Pediatr. Infect. Dis. (IF 0.3) Pub Date : 2023-06-12 Selen Güler, Betül Aksoy, Yeliz Ç. Appak, Sinem Kahveci, Şenay O. Karabağ, Maşallah Baran
Objective Inflammatory bowel disease is a chronic inflammatory disease of the gastrointestinal tract. Some difficulties and differences were experienced during the coronavirus disease 2019 (COVID-19) pandemic period for monitoring of chronic diseases. In this study, the effect of the COVID-19 pandemic on the frequency and course of inflammatory bowel disease in children was evaluated. Methods The first
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Plastic Bronchitis and Human Bocavirus: A Report of Three Cases J. Pediatr. Infect. Dis. (IF 0.3) Pub Date : 2023-05-26 Asli Imran Yilmaz, Ahmet Çopur, Havva Parlatan, Hanife Tuğçe Çağlar, Gökçen Ünal, Fatih Ercan, Abdullah Yazar, Mehmet Özdemir, Sevgi Pekcan
This study aims to investigate and analyze the clinical features of coexisting human bocavirus (HBoV) positivity and plastic bronchitis (PB). We present three cases with no known history of cardiac surgery who presented with cough, progressive dyspnea, and atelectasis. They tested positive for HBoV in a real-time polymerase chain reaction of both nasal lavage fluids. They were diagnosed with PB as
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Evaluation of Ocular Findings Following Multisystem Inflammatory Syndrome in Children J. Pediatr. Infect. Dis. (IF 0.3) Pub Date : 2023-05-23 Aslıhan Sahin, Emine Kaya-Guner, Yıldız Ekemen-Keles, Eda Karadag-Oncel, Ahu Kara-Aksay, Dilek Yilmaz
Objective Multisystem inflammatory syndrome (MIS-C) in children is associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and can be mortal with the involvement of multiple organ systems. However, long-term effects on all organs and organ systems involvement are still unclear or even whether this condition may still occur in which organs. This report aims to identify
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Multisystem Inflammatory Syndrome in Children Associated with COVID-19 Infection: Clinical Presentation and Outcome J. Pediatr. Infect. Dis. (IF 0.3) Pub Date : 2023-05-23 Ritesh Kumar Agrawal, Rewati Sharma, Arpita Mishra, Ashok Singh, Raghvendra Narayan, Om Prakash Mishra
Objective In the midst of the COVID-19 pandemic, many children presenting with persistent fever, rashes, conjunctivitis, abdominal pain, respiratory distress, and shock were reported and diagnosed with multisystem inflammatory syndrome in children (MIS-C). The aim of the study was to observe the clinical presentation and outcome of MIS-C treated at a tertiary care hospital. Methods Eighteen children
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Surgical Site and Blood Stream Infections in Children with Delayed Sternal Closure after Cardiopulmonary Bypass Surgery: A Single-Center Experience J. Pediatr. Infect. Dis. (IF 0.3) Pub Date : 2023-05-01 Evyatar Hubara, Irena Serencev, Or Kriger, Shatzman Steuerman Rachel, Eitan Keizman, Marianne E. Nellis, David Mishali, Reut Kassif Lerner, Uriel Katz, Yelena Skorchin, Galia Barkai, Itai Pessach
Objective Delayed sternal closure (DSC) is a frequent strategy for optimizing hemodynamics for patients after complicated cardiac surgery. However, this practice is associated with increased risk for infection and mortality. Despite the importance of antibiotic prophylaxis during open chest management, no clear recommendations are available. We sought to describe our practice with single-agent prophylactic
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Ophthalmic Manifestations of Multisystem Inflammatory Syndrome in Children J. Pediatr. Infect. Dis. (IF 0.3) Pub Date : 2023-05-01 Melike Emiroglu, Banu Bozkurt, Sule Acar Duyan, Gulsum Alkan, Sadiye Kubra Tuter Oz, Ahmet Sert, Muslu Kazım Korez
Objective The aims of this study were to determine the prevalence and clinical features of ophthalmic involvement in multisystem inflammatory syndrome in children (MIS-C) and to evaluate its association with other organ system involvement and the severity of the disease. Methods The demographic data and information on the ophthalmologic and other systemic organ manifestations, laboratory findings,
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Acute Bronchiolitis in Term Newborns Following Relaxation in COVID-19 Appropriate Behavior J. Pediatr. Infect. Dis. (IF 0.3) Pub Date : 2023-04-26 Umar Amin Qureshi, Abdus Sami Bhat, Mohd Suhail Lone, Muzafar Jan, Nisar Ahmad Wani, Mubashir Hassan Shah
Objective Neonatal bronchiolitis is not well characterized. We studied the profile of acute bronchiolitis in term newborns during a respiratory syncytial virus (RSV) surge following relaxation in coronavirus disease 2019 (COVID-19) appropriate behavior. Methods This was a retrospective descriptive study performed in the neonatology division of a tertiary care pediatric hospital at Srinagar, Jammu and
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Effect of Antibiotics and Gut Microbiota on the Development of Sepsis in Children with Hematopoietic Stem Cell Transplants J. Pediatr. Infect. Dis. (IF 0.3) Pub Date : 2023-04-19 Daniela Potes, Iván Darío Benavides, Nelson Rivera-Franco, Carlos A. Portilla, Oscar Ramirez, Andrés Castillo, Eduardo López-Medina
Objective To describe the association between antibiotic use, gut microbiota composition, and the development of sepsis in pediatric patients undergoing hematopoietic stem cell transplantation (HSCT) to treat acute lymphoblastic leukemia. Methods A cohort of pediatric patients was followed up between days −30 (pre-HSCT) and +30 (post-HSCT), and sequential stool samples were collected for analysis of
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Emergence of Coxsackievirus A16 Causing Childhood Hand, Foot, and Mouth Disease: First Molecular Evidence from Bangladesh J. Pediatr. Infect. Dis. (IF 0.3) Pub Date : 2023-04-18 Sheikh Ariful Hoque, Kazi Selim Anwar, Md. Azraf Hossain Khan, Ummay Nasrin Sultana, Md. Ahasan Ali, Tania Hossain, Laila Shamima Sharmin, ARM Luthful Kabir, Md. Abid Hossain Mollah, Sk. Azimul Hoque, Masuma Khan, Ngan Thi Kim Pham, Pattara Khamrin, Shoko Okitsu, Satoshi Hayakawa, Hiroshi Ushijima
Objective Hand, foot, and mouth disease (HFMD), caused by various human enteroviruses (EVs), has emerged in the children of Bangladesh in recent years. However, the etiological agents of HFMD in Bangladeshi children are not yet elucidated. This study aimed to investigate the causative agents with molecular characterization. Methods Viral RNAs were detected from the blister fluid samples by reverse
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A Rare Presentation of Sphingomonas paucimobilis in a Healthy Child: Acute Ischemic Stroke J. Pediatr. Infect. Dis. (IF 0.3) Pub Date : 2023-04-17 Busra Zeynep Yilmaz, Özge Metin Akcan, Sevgi Pekcan, Havva Parlatan, Ganime Dilek Emlik, Metin Doğan
Sphingomonas paucimobilis is a rarely pathogenic organism that usually infects immunocompromised patients and causes nosocomial infections, but a few community-acquired infections have been identified in relatively healthy adult patients. Herein we report a 5-year-old child who presented with acute ischemic stroke caused by S. paucimobilis that was treated successfully with antibiotics and antithrombotic
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Detection of SARS-CoV-2 Antibodies in Matched Pregnant Women and Newborn Blood J. Pediatr. Infect. Dis. (IF 0.3) Pub Date : 2023-04-11 Zeliha Haytoglu, Eren Haytoglu, Ferda Ozlu, Hacer Yapıcıoglu Yıldızdas, Filiz Kibar, Salih Çetiner, Selvi Gulası, Gulsum Uysal, Ozlem Ozgur Gundeslioglu, Derya Alabaz, Mete Sucu, Umit Celik
Objective The factors affecting the transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies from mother to newborn and the duration of seropositivity rates in these infants have not yet been clearly demonstrated. The objectives of this study were (1) to assess the levels of SARS-CoV-2 spike–specific immunoglobulin G (IgG) in women infected in the pregnancy period and
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Evaluation of Changes in Leukocyte Surface Markers in the Early Diagnosis of Late-Onset Neonatal Sepsis J. Pediatr. Infect. Dis. (IF 0.3) Pub Date : 2023-04-04 Efsun Korkmaz Seven, Cumhur Aydemir, Ishak Ozel Tekin
Objective This study aimed to evaluate the cluster of differentiation (CD)64, CD16, CD11b, CD63 human leukocyte antigen-DR (HLA-DR), and CD62L leukocyte surface marker abnormalities using flow cytometry in the early diagnosis of late-onset neonatal sepsis. Methods Forty-four neonates were included in this study. Of them, 22 neonates with clinical late-onset neonatal sepsis were included in the study
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Unexpected Severe Bocavirus Infections among Hospitalized Children during the COVID-19 Pandemic J. Pediatr. Infect. Dis. (IF 0.3) Pub Date : 2023-04-04 Yalcin Kara, Mahmut Can Kizil, Mehmet Ozgur Arslanoglu, Ebru Kacmaz, Nidai Dalokay, Ezgi Pala, Eylem Kiral, Gürkan Bozan, Tercan Us, Omer Kiliç, Ener Cagri Dinleyici
Objective Acute respiratory tract infections are one of the leading causes of morbidity and mortality in children. Although human bocavirus (HBoV) infections are not as common as other seasonal respiratory viruses, children who are infected with HBoV are more likely to suffer from a variety of respiratory conditions, including the common cold, acute otitis media, asthma exacerbations, bronchiolitis
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Low Mortality among Under-5 Children with Severe Community-Acquired Pneumonia: A 5-Year Retrospective Analysis of 588 Admissions in Ibadan, Nigeria J. Pediatr. Infect. Dis. (IF 0.3) Pub Date : 2023-04-04 Olugbenga Oyewumi Akinrinoye, Adeyinka Adeyemi Labaeka, Kayode Raphael Fowobaje, Hamish Graham, Adegoke Gbadegesin Falade
Objective Community-acquired pneumonia (CAP) is the commonest cause of death in under-5 children worldwide. Although the mortality from CAP has decreased over the last decade, it is still unacceptably high in lower-middle-income countries (LMICs). We aimed to determine the case fatality rate (CFR), and factors associated with treatment failure and outcome, using recommended antimicrobials. Methods A
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Investigation of Oral and Fecal Colonization with Candida Species and Associated Factors in Human Immunodeficiency Virus-Infected Children in Turkey J. Pediatr. Infect. Dis. (IF 0.3) Pub Date : 2023-03-31 Esma Akkoyun Bilgi, Gonca Erköse Genç, Manolya Kara, Eda Kepenekli Kadayıfçı, Selda Hançerli Törün, Canan Baydemir, Ayper Somer, Ali Ağaçfidan, Zayre Erturan
Objective The risk of endogenous infections in human immunodeficiency virus (HIV)-infected individuals increases with Candida species colonized in mouth and intestinal areas. The predisposing factors for colonization and the prevalence of different Candida spp. in HIV-infected Turkish children remain unknown. This study aimed to determine the colonization frequency and risk factors of colonization
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Effectiveness of Chlorhexidine-Impregnated Central Venous Catheter Dressing for Preventing Catheter-Related Bloodstream Infections in Pediatric Patients: A Systematic Review and Meta-Analysis Study J. Pediatr. Infect. Dis. (IF 0.3) Pub Date : 2023-03-30 Ebru Melek Benligül, Murat Bektaş
Objective The study's objective was to use meta-analysis to assess the effectiveness of a dressing impregnated with chlorhexidine in preventing catheter-related bloodstream infections (CRBSIs) in pediatric patients. Methods The study was conducted and reported using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. A comprehensive search of 18 databases was conducted
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Relationship between Initial Lactate Level with Mortality in Children with Sepsis and Septic Shock: A Comparison with the PRISM-3 Score J. Pediatr. Infect. Dis. (IF 0.3) Pub Date : 2023-03-30 Göksu Başargan, Mustafa Argun, Hasan Samsa
Objective Sepsis and septic shock are leading causes of mortality and morbidity in intensive care units. Our study aimed to compare the pediatric risk of mortality (PRISM-3) score, which is used for predicting mortality risk among critically ill patients in pediatric intensive care units, with laboratory parameters, particularly lactate parameters. Methods This study included 38 patients aged 1 month
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A Significant Role of Nontypeable Haemophilus influenzae in Acute Otitis Media in Bulgarian Children J. Pediatr. Infect. Dis. (IF 0.3) Pub Date : 2023-03-20 Alexandra Sashova Alexandrova, Preslava Hristova, Hristina Hitkova, Raina Tsvetanova Gergova
Objective We conducted a study on Haemophilus influenzae isolates recovered from children with acute otitis media (AOM). We aimed to establish the distribution of noncapsulated (also known as nontypeable Haemophilus influenzae [NTHi]) and encapsulated H. influenzae in the study population, and the antimicrobial susceptibilities of the isolates. Methods We collected 113 nasopharyngeal swabs and 91 middle
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Predicting Factors of Brucella melitensis Bacteremia in Children Admitted with Brucellosis J. Pediatr. Infect. Dis. (IF 0.3) Pub Date : 2023-03-16 Tuğba Erat, Tuğba Meliha Fatma Ercan, Halil Aslan, Abdullah Solmaz
Objective Brucellosis is the most common zoonotic disease. Isolation of Brucella melitensis in blood culture is accepted as the gold standard for diagnosis. This study aims to determine the predictive factors of B. melitensis bacteremia in pediatric patients followed up with brucellosis. Methods Two-hundred twenty pediatric brucellosis patients were included in the study. The epidemiological, clinical
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Reactivation of Tuberculosis and COVID-19 in Pediatric Patients J. Pediatr. Infect. Dis. (IF 0.3) Pub Date : 2023-02-17 Gökçen Ünal, Sevgi Pekcan, Özge Metin Akcan, Sevgi Keleş, Aslı İmran Yılmaz, Fadime Ceyda Eldeniz, Hanife Tuğçe Çağlar, Mehmet Özdemir, Necdet Poyraz, Fahriye Kılınç, Ayşe Bulut
Objective Mycobacterium tuberculosis is an immobile aerobic bacillus that causes tuberculosis (TB) disease. We aimed to evaluate the association between coronavirus disease 2019 (COVID-19), COVID-19-related drugs, TB reactivation, and TB incidence during the pandemic. Methods Eight patients who were diagnosed as having TB in Meram Medical Faculty, Necmettin Erbakan University between March 1, 2020
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Epidemiology of Respiratory Syncytial Virus-Associated Acute Lower Respiratory Tract Infection among Hospitalized Under-5s in Northwestern Nigeria J. Pediatr. Infect. Dis. (IF 0.3) Pub Date : 2023-01-16 Maria Ahuoiza Garba, Fatima Jummai Giwa, Hamdala Adelaiye, Abiola Aira Olorukooba, Fatima Abdullahi, Hauwa Makarfi, Yvette Löwensteyn, Louis Bont, Fadlullah Abdurraheem, Ehi Uudu, Halima Mudasir, Natalie I Mazur
Objective Globally, 33 million cases of respiratory syncytial virus (RSV) infections occur annually among under-fives (5s). Ninety-nine percent of deaths from RSV occur in low- and middle-income countries. Under-five pneumonia mortality in Nigeria was estimated at 140,520 in 2017, but RSV epidemiological data are scant due to poor awareness and limited testing. Vaccines for RSV are currently under
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Parents' Attitudes toward COVID-19 Vaccination: A Study from Two Centers in European and Anatolian Sides of Istanbul J. Pediatr. Infect. Dis. (IF 0.3) Pub Date : 2023-01-06 Selve Çınaroğlu Saka, Hale Molla Kafi, Zeynep Ebru Çakın, Cem Koray Fırat, Ali Toprak, Özden Türel
Objective Vaccination is an important measure for the prevention of coronavirus disease 2019 (COVID-19). In the present study, we aimed to evaluate parents' attitudes toward vaccinating themselves and their children. We also searched whether information about the multisystem inflammatory syndrome in children (MIS-C), a severe complication of COVID-19, could change parents' decisions on vaccinating
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Rash and Gastrointestinal Dysfunction May Indicate Cardiac Involvement in Children with Multisystem Inflammatory System Associated with Coronavirus Disease 2019 J. Pediatr. Infect. Dis. (IF 0.3) Pub Date : 2023-01-05 Ayhan Pektaş, Ayşegül Bükülmez, Mehmet Çeleğen, İbrahim Eker
This study aims to investigate the management of children diagnosed with “multisystem inflammatory syndrome” (MIS-C) potentially associated with coronavirus disease 2019 (COVID-19) at a tertiary health center. This is a retrospective review of 34 children who were diagnosed with MIS-C at the pediatrics department of the study center from August 2021 to December 2021. Data related to age, sex, body
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Epidemiology and Acute Respiratory Distress Syndrome Propensity of Viral Respiratory Infections in Pediatric Intensive Care Units Prior to the Coronavirus Disease 2019 Pandemic J. Pediatr. Infect. Dis. (IF 0.3) Pub Date : 2023-01-05 Gültaç Evren, Tolga Besci, Özgür Appak, Ayça Arzu Sayıner, Gazi Arslan, Murat Duman
This study aimed to determine the epidemiology and acute respiratory distress syndrome (ARDS) propensity of common respiratory viruses in a tertiary pediatric intensive care unit (PICU) among hospitalized children who were tested for respiratory viruses by polymerase chain reaction (PCR) prior to the coronavirus disease 2019 (COVID-19) pandemic. Respiratory tract samples were collected from patients
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Childhood Anemia and Risk for Acute Respiratory Infection, Gastroenteritis, and Urinary Tract Infection: A Systematic Review J. Pediatr. Infect. Dis. (IF 0.3) Pub Date : 2022-12-30 Ushani Jayamanna, J. A. A. Sampath Jayaweera
Objective Children younger than 5 years, particularly children below 2 years, are among the most vulnerable groups for developing anemia and infections. This review is intended to assess the association between anemia and childhood acute respiratory infections (ARTIs), acute gastroenteritis (AGE), and urinary tract infections (UTIs). Methods PubMed was searched for published articles from January 2000
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SARS-CoV-2 Transmission among Students after the Full Reopening of Schools J. Pediatr. Infect. Dis. (IF 0.3) Pub Date : 2022-12-30 Gülsüm İclal Bayhan, Halise Akça, Ayla Akça Çağlar, Funda Kurt, Leman Akcan Yıldız, Saliha Şenel, Can Demir Karacan
Objective Closing of schools within the scope of the pandemic measures and switching to online education have negatively affected the mental and physical health of children as well as their education. The effect of complete reopening of schools on the transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is not fully known. In the 2021–2022 academic year, the Ministry of National
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Experience with Methicillin-Resistant Staphylococcus aureus in a Central London Tertiary Pediatric Hospital J. Pediatr. Infect. Dis. (IF 0.3) Pub Date : 2022-12-26 Kayden Chahal, Kareem Omran, Rakesh Vora, Manasvi Upadhyaya
Objective Methicillin-resistant Staphylococcus aureus (MRSA) infection is very serious, and thus, it is common practice, worldwide, to screen for MRSA colonization at admission and institute decolonization procedures. Our aim was to review adherence to local guidelines and sepsis risk in pediatric patients with a focus on surgical cases. Methods A retrospective case note review was conducted from January
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A Survey on Parents' Health Literacy on Childhood Human Papilloma Virus Vaccination J. Pediatr. Infect. Dis. (IF 0.3) Pub Date : 2022-12-26 Ömer Güneş, Aslınur Özkaya-Parlakay, Ahmet Yasin Güney, Latife Güder, Özlem Mustafaoğlu, Pınar Bayraktar, Saliha Kanık-Yüksek, Belgin Gülhan
Objective The aim of this study is to determine parents' knowledge levels and attitudes about childhood human papillomavirus (HPV) vaccination and reveal the differences between parents who are health care workers and nonhealth care workers. The HPV vaccine can potentially prevent initial HPV infection and HPV-related genital and anal precancerous disorders and cancers. Methods Questions and attitudes
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Association of Tumor Necrosis Factor-Alpha (TNF-α) and Suppressor of Cytokine Signaling-1 (SOCS-1) Gene Variants in Children with COVID-19 J. Pediatr. Infect. Dis. (IF 0.3) Pub Date : 2022-12-26 Metin Uysalol, Istemi Serin, Yasemin Oyacı, Raif Yıldız, Ezgi Uysalol, Sacide Pehlivan
Objective The suppressor of cytokine signaling-1 (SOCS-1) gene is an essential physiological regulator of cytokine signaling. Tumor necrosis factor-α (TNF-α) is an important component of the immunological response. Herein, we aimed to investigate the effects of SOCS-1 (-1478 CA > Del) and TNF-α (-308) polymorphisms on disease susceptibility and prognosis in pediatric patients with coronavirus disease
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Incidence and Risk Factors of Hyperglycemia in Severe Multisystem Inflammatory Syndrome in Children: A Retrospective Case-Control Study J. Pediatr. Infect. Dis. (IF 0.3) Pub Date : 2022-12-01 Ozlem Saritas Nakip, Selman Kesici, Betul Seda Bozkurt, Yasemin Ozsurekci, Huseyin Demirbilek, Benan Bayrakci
Objective Multisystem inflammatory syndrome in children (MIS-C) patients might be at risk for hyperglycemia and associated complications. Herein, we aimed to determine the incidence of hyperglycemia, understanding the underlying risk factors in MIS-C patients. Methods All MIS-C patients were retrospectively evaluated and compared according to the presence of hyperglycemia and the need of insulin. Inflammatory