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Turkish Translation and Cross-Cultural Validity of Whoqol-HIV Bref Tool Curr. HIV Res. (IF 1.0) Pub Date : 2024-03-01 Okan Derin, Ahsen Öncül, Hakkı Meriç Türkkan, Nazife Duygu Demirbaş, Özlem Gül, Hüsrev Diktaş, Dilek Yıldız Sevgi, Osman Hayran
Background: The assessment of health-related quality of life among people living with HIV (PLWH) has gained increasing importance as it assesses their overall well-being, guides treatment decisions, and addresses psychosocial challenges, improving their quality of life. This study focuses on adapting and validating the Turkish version of the WHOQOL-HIV Bref, a tool developed by the World Health Organization
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Sagittal Abdominal Diameter as the Best Predictor of Metabolic Syndrome in HIV-Infected Men on Antiretroviral Therapy Curr. HIV Res. (IF 1.0) Pub Date : 2024-02-07 Zorka Drvendžija, Biljana Srdić Galić, Miloš Vujanović, Daniela Marić, Nina Brkić Jovanović, Snežana Brkić, Vesna Turkulov, Dalibor Ilić
Background: The interaction of human immunodeficiency virus (HIV), host and antiretroviral therapy causes a range of metabolic disorders that can be characterized as a metabolic syndrome (MetS) that increases the cardiovascular risk. MetS involves central obesity, which can be detected using different anthropometric parameters. Objective: To assess the abilities of different anthropometric parameters
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Feasibility of a Mobile Health Intervention for Providing a Continuum of HIV Services for MSM: Pilot Study of the WeTest Program in 3 Cities in China Curr. HIV Res. (IF 1.0) Pub Date : 2024-02-04 Zhihui Zhu, Xiaoyan Lu, Pan Gao, Xiaodong Wang, Xuejiao Hu, Nianhua Xie, Cong Liu, Yue Zhao, Yanqiu Zhao, Zhen Dai, Hongbo Zhang, Jun Wang, Yehuan Sun, Tao Liu, Shufang Sun, Cui Yang, Nickolas Zaller, Zhihua Zhang, Don Operario
Background:: Men who have sex with men (MSM) in China have a high risk for HIV infection but experience suboptimal rates of HIV testing and service engagement due to various social and structural barriers. We developed a mobile health (mHealth) intervention entitled “WeTest-Plus” (WeTest+) as a user-centered “one-stop service” approach for delivering access to comprehensive information about HIV risk
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Mortality Risk Factors Among People Living with HIV Receiving Second--line Antiretroviral Therapy in Rural China Curr. HIV Res. (IF 1.0) Pub Date : 2024-02-04 Qiujia Kang, Wanqi Pan, Yanmin Ma, Dongli Wang, Huangchao Jia, Huijun Guo, Feng Sang, Liran Xu, Qianlei Xu, Yantao Jin
Background: Second-line antiretroviral therapy (ART) was introduced in Henan Province in 2009. The number of people living with human immunodeficiency virus (HIV) starting this therapy is increasing. Objective: This study aimed to investigate the survival and factors affecting mortality among this group. Methods: We conducted a retrospective cohort study of people living with HIV (PLHIV) who switched
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Dynamic Linkages among HIV/AIDS, Health Expenditures, Environmental Degradation, Life Expectancy, and Economic Growth: A Case of Eastern Africa Countries Curr. HIV Res. (IF 1.0) Pub Date : 2024-02-04 Tuncer Govdeli
Background: Eastern African countries are among the countries with a very high HIV/AIDS prevalence rate. High HIV/AIDS prevalence is a problem that has a detrimental effect on the economic development of these countries. Previous studies have generally examined the relationship of HIV/AIDS with life expectancy or economic growth. In this study, three different models have been established and the relationship
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Human immunodeficiency virus-1 Drug Resistance Mutations in Iranian Treatment-experienced Individuals Curr. HIV Res. (IF 1.0) Pub Date : 2024-02-04 Farah Bokharaei-Salim, Khadijeh Khanaliha, Seyed Hamidreza Monavari, Seyed Jalal Kiani, Ahmad Tavakoli, Ensieh jafari, Sara Chavoshpour, Mohammad Hossein Razizadeh, Saeed Kalantari
Background: Human immunodeficiency virus-1 infection still remains a global health threat. While antiretroviral therapy is the primary treatment option, concerns about the emergence of drug-resistance mutations and treatment failure in HIV-infected patients persist. Objective: In this study, we investigated the development of drug resistance in HIV-1-infected individuals receiving antiretroviral therapy
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A Phase-IV Non-interventional Study to Assess Virological Effectiveness, Safety, and Tolerability of DTG-based Antiretroviral Therapy in HIV-1 Infected Indian Persons Living with HIV Curr. HIV Res. (IF 1.0) Pub Date : 2024-01-29 Kuldeep Ashta, Sumit Arora, Rajesh Khanna, Anirudh Anilkumar, Nishant Raman, Charu Mohan
Background: Dolutegravir (DTG) is a novel yet preferential first-and-second-line treatment for persons living with HIV (PLH). Owing to its recent introduction, DTG-based regimens have not undergone a comprehensive, systematic evaluation regarding their real-world utilization and safety profile among a sizeable Indian population. Objective: This study aimed to assess the 24-week immunovirological outcomes
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The Upper-gastrointestinal Endoscopic Findings of People Living with HIV: A Systematic Review Curr. HIV Res. (IF 1.0) Pub Date : 2024-01-26 Seyed Ahmad Alinaghi, Nazanin Janfaza, Pegah Mirzapour, Haleh Siami, Zoha Ali, Parisa Matini, Elaheh Karimi, Sona Mahrokhi, Sanaz Varshochi, Foziye Sanaati, Masoomeh Fathi Amrollah, Sobhan Saki, Esmaeil Mehraeen, Omid Dadras
Objective:: This article aimed to analyze upper endoscopic findings in the HIV patient population to elucidate the upper-gastrointestinal complications related to HIV infection. Gastrointestinal (GI) disorders in individuals living with HIV/AIDS exhibit diverse and often nonspecific manifestations, imposing substantial morbidity and mortality burdens. Endoscopic evaluation with biopsies is essential
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Bone Metabolism in Men who Live with HIV Aged 50 years and Over: Impact of Infection Duration Curr. HIV Res. (IF 1.0) Pub Date : 2024-01-26 Bilge Caglar, Emre Durcan, Ridvan Karaali, Ilker Inanc Balkan, Sibel Yildiz Kaya, Hakan Yavuzer, Dildar Konukoglu, Gokhan Aygun, Nese Saltoglu, Iclal Nur Bulut, Kerim Sonmezoglu, Pinar Kadioglu, Bilgul Mete, Omer Fehmi Tabak
Background: Early diagnosis and effective antiretroviral therapy (ART) lead to similar life expectancy in people living with HIV (PLWH) compared to the general population. This population faces problems such as decreased bone mineral density (BMD) and increased fracture risk. The aim of this study was to determine the prevalence of osteoporosis in men aged 50 years and over who were PLWH and to determine
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Endobronchial Tuberculosis in an HIV-positive Case Curr. HIV Res. (IF 1.0) Pub Date : 2024-01-26 Savaş Gegin, Burcu Özdemir, Özgür Günal, Şeyma Topal, Çiğdem Uzun, Levent Özdemir
Introduction: Tuberculosis is an opportunist infection that is fatal and most frequently seen in HIV-positive patients due to immunosuppression. Endobronchial lesions can portray symptoms in different ways. Endobronchial Tuberculosis is one of these lesions. Case Report: An HIV-positive, untreated 26-year-old patient with fever, cough, and dyspnea consulted our clinic. In the chest X-ray taken, effusion
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The Interrelationship Between HIV Infection and COVID-19: A Review of the Literature Curr. HIV Res. (IF 1.0) Pub Date : 2023-12-28 Yiyu Wang, Yu Lai
: The Corona Virus Disease 2019 (COVID-19) pandemic resulting from the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to significant morbidity and mortality in patients and put a strain on healthcare systems worldwide. The clinical characteristics and results of COVID-19 in immunosuppressed patients, such as people living with human immunodeficiency virus (PLWH), considered at
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Discordance of Aqueous/Plasma HIV Replication on ART Curr. HIV Res. (IF 1.0) Pub Date : 2023-12-28 Xin Che, Luoziyi Wang, Weimei Ma, Rui Wang, Zhiliang Wang
Background: The study was conducted to analyze HIV dynamics across blood–retinal barrier (BRB) and the relevant risk factors for HIV-associated ocular complications. Methods: This study included a case series of 40 HIV-positive patients with ocular lesions, which were studied retrospectively. Clinical and laboratory examinations included plasma and intraocular viral load (VL). Results: HIV VL on paired
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Older PLHIV are at Higher Cardiovascular Risk with Poor Quality of Life Curr. HIV Res. (IF 1.0) Pub Date : 2023-12-21 Muhammed Shabil, Krishna Murti, V Udaya Kumar, Rishikesh Kumar, Nitesh Kumar, Sameer Dhingra, Vipan Kumar Parihar, V Ravichandiran, Krishna Pandey
Background: People with HIV (PLHIV) face increased cardiovascular disease (CVD) risk due to inflammation and immune activation. Aging further amplifies this risk. Limited data exist on CVD risk in older PLHIV in India despite 2.14 million PLHIV with higher CVD risk factors. Methods: In a cross-sectional study in Bihar, India, 73 PLHIV and 30 control participants were enrolled. Demographics, social
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Prevalence of Erectile Dysfunction (ED) among People Living with HIV in Tehran, Iran Curr. HIV Res. (IF 1.0) Pub Date : 2023-12-06 SeyedAli Dehghan Manshadi, Ali Keyhani Pirdehi, Elnaz Shahmohamadi, Malihe Hasan Nezhad, Faezeh Abbaspour, Sona Mahrokhi, SeyedAhmad SeyedAlinaghi
Background: Sexual problems are rarely addressed in human immunodeficiency virus (HIV) management, even though overt sexual dysfunctions are more prevalent in people living with HIV. This study aimed to ascertain the prevalence of erectile dysfunction (ED) among HIVinfected men in a stable clinical state, examine the relationship between antiretroviral therapy (ART) exposure and sexual dysfunction
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Alarming Rise of Primary HIV Drug Resistance in Major Regions of Russia Curr. HIV Res. (IF 1.0) Pub Date : 2023-12-06 Dmitry Kireev, Alina Kirichenko, Aleksey Lebedev, Marina Bobkova
Objective: The study aimed to compare the prevalence of surveillance HIV drug resistance mutations (SDRMs) across the main federal districts of Russia. Methods: A pooled analysis was conducted to examine data on HIV primary drug resistance (HIV PrimDR). The analysis was based on published results primarily from Russian regional clinical and scientific laboratories, covering a span of 20 years. Results:
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The Importance of Traditional Chinese Medicine in the Intervention and Treatment of HIV while Considering its Safety and Efficacy Curr. HIV Res. (IF 1.0) Pub Date : 2023-12-01 Mohamad Hesam Shahrajabian, Wenli Sun
Natural products have been considered a potential resource for the development of novel therapeutic agents, since time immemorial. It is an opportunity to discover cost-effective and safe drugs at the earliest, with the goal to hit specific targets in the HIV life cycle. Natural products with inhibitory activity against human immunodeficiency virus are terpenes, coumarins, flavonoids, curcumin, proteins
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Factors Associated with Fatal COVID-19 Outcomes among People Living with HIV: A Cohort Study Curr. HIV Res. (IF 1.0) Pub Date : 2023-11-30 Elena Drobyshevskaya, Aleksey Lebedev, Alexander Pronin, Marina Bobkova
Background: People living with HIV (PLHIV) are at increased risk of COVID-19 death. However, information about whether factors related to the HIV-infection influence the COVID-19 outcome still remains conflicting. Objective: Here, we evaluate the risk factors for fatal COVID-19 in a cohort of PLHIV from the Moscow region, aged >18 years and diagnosed with COVID-19 between March 2020 and December 2021
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Design, Synthesis, Docking Studies, and Biological Evaluation of Novel 2-Hydroxyacetophenone Derivatives as Anti-HIV-1 Agents Curr. HIV Res. (IF 1.0) Pub Date : 2023-11-16 Samira Sooreni Oliaie, Mahdieh Safakish, Rouhollah Vahabpour Roudsari, Mohammad Mahboubi-Rabbani, Zahra Hajimahdi, Afshin Zarghi
Background: The persistence of HIV mutations and the existence of multidrug resistance have produced an opportunity for an array of innovative anti-HIV medicines with a variety of structures that target HIV key enzymes. Objective: The goal of this work was to find a new class of anti-HIV drugs founded on HIV integrase inhibitor pharmacophores. Methods: A novel class of 2-hydroxy acetophenone analogs
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Comparison of Metabolic Effects of Three Different Treatment Combinations with Retrospective Real-life Data in People Living with HIV Curr. HIV Res. (IF 1.0) Pub Date : 2023-11-16 Adem Simsek, Oguz Karabay, Ertugrul Guclu, Hande Toptan
Introduction: Comorbidities are increasing in people living with HIV (PLHIV), and different treatment options have advantages and disadvantages. It is important to compare information from real-life treated cases. The aim of this study was to retrospectively evaluate the data on efficacy and clinical and laboratory findings during different antiretroviral therapies. Methods: Retrospective file data
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Three Novel CRF01_AE/CRF07_BC Recombinant Forms of HIV-1 Identified in Shijiazhuang City, China Curr. HIV Res. (IF 1.0) Pub Date : 2023-11-08 Xinli Lu, lin ma, Li Yan, meng liu, yingying wang, ning an, qi li
Background:: Hebei, a province with a low Human Immunodeficiency Virus (HIV) prevalence, is also a region with the most abundant HIV-1 genetic diversity. HIV-1 recombinant forms have been the key factor influencing the effectiveness of HIV-1 control and therapy. Objectives:: We aimed to study inter-subtype recombinant structures of new HIV-1-second generation recombinant forms. Methods:: Monitoring
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Analysis of the Efficacy of Drilling Decompression Autologous Bone Marrow and Allogeneic Bone Grafting in the Treatment of HIV-positive Patients with Early Osteonecrosis of the Femoral Head Curr. HIV Res. (IF 1.0) Pub Date : 2023-11-08 Li Shengtao, Wang Jie, Ma Rui, Zhao Changsong, Pu Yu, He Min, Gao Zhengrong, Quan Xuemin, Zhang Qiang
Objective:: To investigate the efficacy of treating patients with HIV-positive osteonecrosis of the femoral head using drilled decompression autologous bone marrow and allogeneic bone grafting.To investigate the efficacy of treating patients with HIV-positive osteonecrosis of the femoral head using drilled decompression autologous bone marrow and allogeneic bone grafting. Methods:: 40 patients (44
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Cognitive Behavioral Therapy for AIDS Prevention among College Students in China: A Cluster Randomized Controlled Trial Curr. HIV Res. (IF 1.0) Pub Date : 2023-11-03 Yumeng Lei, Xiaochen Xiang, Lingxue Chen, Mingxin He, Simin Li, Qiang Wang
Background: Acquired immune deficiency syndrome (AIDS) is a serious worldwide public health problem and has become the focus of prevention and control in China, while the student population is the key population for AIDS prevention. Objective: The purpose of this study was to investigate the effects of cognitive behavioral therapy (CBT) on college students' AIDS-related cognitions, attitudes, and behaviors
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Coexıstence of Cryptococcal Fungemıa and Pneumocystıs Jırovecıı Pneumonıa ın an HIV-ınfected Patıent: A Case Report Curr. HIV Res. (IF 1.0) Pub Date : 2023-10-25 Tuba TATLI KIŞ, Süleyman Yıldırım, Can Biçmen, Nur Yücel, Cenk Kıraklı
Introduction: Opportunistic infections caused by bacteria and fungi are common in human ımmunodeficiency virus (HIV)-infected patients. Cryptococcus neoformans and Pneumocystis jirovecii are the most common opportunistic infections in immunosuppressed individuals, but their coexistence is rare. To our knowledge, this is the first case presented in Turkey involving the coexistence of C.neoformans fungemia
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Prevalence of Toxoplasma gondii in HIV-Infected Individuals in Iran: A Systematic Review and Meta-Analysis Curr. HIV Res. (IF 1.0) Pub Date : 2023-10-19 pegah shakib, Masoud Behzadifar, Hossein Mahmoudvand, Sara Larki, Hamed kalani, Masoomeh Zivdari, Omid Mardanshah, Kourosh Cheraghipour
Introduction: Toxoplasma gondii is an obligate intracellular protozoan that can infect almost all warm-blooded animals, including humans. Patients with co-infection with toxoplasmosis and HIV have a 30-40% risk of developing toxoplasmosis encephalitis. This study aimed to describe the epidemiology and burden of Toxoplasma gondii in HIV-infected individuals in Iran. Methods: We searched the five English
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Differential Diagnosis or Etiology: A Case Report on Amyotrophic Lateral Sclerosis-like Neuropathy Associated with HIV Infection Curr. HIV Res. (IF 1.0) Pub Date : 2023-10-16 Renato Barradas Rodrigues, Marco Orsini, Sofia Vieira Neves, Wladimir Bocca Vieira de Rezende Pinto, Antônio Marcos da Silva Catarino, Daniel Antunes Pereira, Acary Souza Bulle Oliveira
Background: Retroviruses are described as a risk factor for chronic neuropathy. However, it is still unknown if they can work as amyotrophic lateral sclerosis triggers. Over the years, some cases of this association have been described with heterogenous disclosures. Case Representation: This study aimed to report a case of HIV and ALS-like neuropathy and briefly discuss peculiarities of clinical aspects
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Novel Aptamers for the Reactivation of Latent HIV Curr. HIV Res. (IF 1.0) Pub Date : 2023-10-04 William Serumula, Bongani Nkambule, Raveen Parboosing
Introduction: A “Shock and Kill” strategy has been proposed to eradicate the HIV latent viral reservoir. Effective Latency Reversal Agents (LRA) are a key requirement for this strategy. The search for LRAs with a novel mechanism of action is ongoing. This is the first study to propose aptamers for the reactivation of HIV. Objective: The purpose of this study was to identify an aptamer that potentially
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Donating One’s Body to HIV Cure Research Through Canadian Medical Assistance in Dying: A Case Study Curr. HIV Res. (IF 1.0) Pub Date : 2023-09-06 David Lessard, Bertrand Lebouché, André Morneau, Martin Bilodeau, Ron Rosenes, Justin Sanders, Nicolas Chomont, Patrick Keeler, Karine Dubé, Shari Margolese, Mohammad-Ali Jenabian, Christopher Power, Jean-Pierre Routy, Jonathan B. Angel, Eric A. Cohen, Cecilia T. Costiniuk
Background: Finding a cure for HIV is challenged by persisting reservoirs, the mapping of which necessitates invasive procedures. Inviting people with HIV (PWHIV) at the end of life to donate body specimens post-mortem through research autopsies is a novel approach, raising ethical concerns. Objective: This case study aims to explore the motivations, barriers, and facilitators of a terminally-ill Canadian
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Identification of the Near Full-length Genome of a Novel HIV-1 CRF01_AE/CRF07_BC Recombinant with a Complex Genomic Structure Isolated in Hebei Province, China Curr. HIV Res. (IF 1.0) Pub Date : 2023-08-29 Weiguang Fan, Weina An, Jianru Jia, Haoxi Shi, Miaomiao Su, Juan Meng
Background: During HIV genotypic drug resistance testing of patient samples in Baoding, Hebei Province, China, in 2022, a recombinant fragment was detected in the pol region of an HIV-1 strain. Objective: The objective of the study was to analyze the near full-length genome of a novel HIV-1 CRF01_AE/CRF07_BC recombinant with a complex genomic structure. Methods: Viral RNA was extracted from the blood
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Detection of Non-Alcoholic Fatty Liver Disease with Non-invasive Tools in Turkish People Living with HIV and with Apparently Normal Liver Function Curr. HIV Res. (IF 1.0) Pub Date : 2023-08-07 Nursel Çalık Başaran, İlkay İdilman, Hayriye Altunay Tokuçoğlu, Mehmet Ruhi Onur, Meliha Çağla Sönmezer, Lale Özışık, Muşturay Karçaaltıncaba, Ahmet Çağkan İnkaya, Serhat Ünal
Background: Non-alcoholic fatty liver disease (NAFLD) has become a significant cause of mortality and morbidity in people living with HIV. Objective: We aimed to investigate NAFLD presence by magnetic resonance imaging (MRI) methods, including MRI-derived proton density fat fraction (MRI-PDFF) and MRE, and ultrasound elastography among Turkish people living with HIV (PLWH), and identify factors correlated
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Changes in Leptin to Adiponectin Ratio After Antiretroviral Therapy: A Pilot Observational Study Curr. HIV Res. (IF 1.0) Pub Date : 2023-08-04 Shinichi Hikasa, Shota Shimabukuro, Kyoko Hideta, Satoshi Higasa, Akihiro Sawada, Tazuko Tokugawa, Kuniyoshi Tanaka, Mina Yanai, Takeshi Kimura
Aim: Weight gain with the use of dolutegravir, bictegravir, and tenofovir alafenamide for antiretroviral therapy has been reported. However, studies on changes in body composition and the leptin/adiponectin ratio after antiretroviral therapy initiation are limited. These factors are important because they can be used as indicators of metabolic syndrome and cardiovascular disease risk. Introduction:
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The prevalence of HLA-B*57 serotype associated with hypersensitivity reactions in the treatment of HIV infection in the Turkish population Curr. HIV Res. (IF 1.0) Pub Date : 2023-08-01 Muhammed Ali Kizmaz, Abdurrahman Simsek, Figen Aymak, E. Halis Akalin, H. Barbaros Oral, Ferah Budak
Objectives: The aim of our study is to reveal the prevalence of HLA-B*57 in the Turkish population and to provide new perspectives to physicians starting abacavir therapy in HIV patients. Background: Abacavir, one of the drugs used to treat HIV infection, can cause hypersensitivity reactions in some patients. These hypersensitivity reactions have been shown to be associated with the HLA-B*57:01 allele
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Biomarkers of Growth Faltering and Neurodevelopmental Delay in Children who are HIV-Exposed but Uninfected: A Systematic Review Curr. HIV Res. (IF 1.0) Pub Date : 2023-07-20 Reshma Sirajee, Jason Brophy, Andrea L. Conroy, Sophie Namasopo, Robert O. Opoka, Urvi Rai, Sarah Forgie, Bukola O. Salami, Michael T. Hawkes
Introduction: Children who are HIV-exposed but uninfected (CHEU) are at risk of linear growth faltering and neurodevelopmental delay. Circulating biomarkers associated with these adverse outcomes may elucidate pathways of injury. Objective: To identify biomarkers associated with growth faltering and neurodevelopmental delay in CHEU. Methods: We performed a systematic review of electronic databases
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Late Diagnosis at Entry on Care in an HIV Clinic in Mexico City: Possibly COVID-19 Pandemic Impact Curr. HIV Res. (IF 1.0) Pub Date : 2023-07-18 Elizalde-Barrera Cesar Ivan, Juarez-Mendoza Carlos Virgilio
Background: HIV late-stage diagnoses have an important impact on mortality. Unfortunately, a significant number of patients are still diagnosed at late stages. On the other hand, the coronavirus disease 2019 (COVID-19) pandemic has created an unprecedented crisis in healthcare systems worldwide, including HIV care services. The aim of this study was to compare time-trends in HIV late diagnosis, prevalence
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Prevalence of Transmitted Drug Resistance among HIV-1 Patients in the Aegean Region: Results from the Western Part of Turkey Curr. HIV Res. (IF 1.0) Pub Date : 2023-06-22 Ruchan Sertoz, Duygu Tekin, Selda Erensoy, Servet Biceroglu, Figen Kaptan, Sukran Köse, Hulya Ozkan, Banu Cetin, Melda Türken, Deniz Gokengin
Objectives: This study aimed to analyze the antiretroviral drug resistance in antiretroviral treatment-naïve HIV-positive patients in the Aegean Region of Turkey from 2012 to 2019. Methods: The study included 814 plasma samples from treatment-naïve HIV-positive patients. Drug resistance analysis was performed by Sanger sequencing (SS) between 2012-2017 and by next-generation sequencing sequencing (NGS)
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HIV Preintegration Transcription and Host Antagonism Curr. HIV Res. (IF 1.0) Pub Date : 2023-06-27 Yuntao Wu
Retrovirus integration is an obligatory step for the viral life cycle, but large amounts of unintegrated DNA (uDNA) accumulate during retroviral infection. For simple retroviruses, in the absence of integration, viral genomes are epigenetically silenced in host cells. For complex retroviruses such as HIV, preintegration transcription has been found to occur at low levels from a large population of
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Cognitive Deficits: Verbal and Semantic Fluency in People Living with HIV and AIDS Curr. HIV Res. (IF 1.0) Pub Date : 2023-06-27 Ganka Ivanova, Rakan Alhrahsheh, Kaloyan Kukov
Background: Since the beginning of the HIV epidemic, the virus has taken millions of lives worldwide. The United Nations AIDS Fund’s statistics reported that deaths caused by HIVrelated conditions and AIDS were about 39 million from the beginning of the epidemic to 2015. The united global efforts to fight the virus are considerably changing the indicators, such as mortality and morbidity, but the challenges
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A Combination of Novel HIV-1 Protease Inhibitor and Cytochrome P450 (CYP) Enzyme Inhibitor to Explore the Future Prospective of Antiviral Agents: Evotaz Curr. HIV Res. (IF 1.0) Pub Date : 2023-06-26 Abha Sharma, Poonam Sharma, Isha Kapila, Vikrant Abbot
Viruses belong to the class of micro-organisms that are well known for causing infections in the human body. Antiviral medications are given out to prevent the spread of disease-causing viruses. When the viruses are actively reproducing, these agents have their greatest impact. It is particularly challenging to develop virus-specific medications since viruses share the majority of the metabolic functions
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Longitudinal Assessment of Virological Failure and Antiretroviral Drug Resistance among Treatment-naive Subjects Living with HIV Curr. HIV Res. (IF 1.0) Pub Date : 2023-06-23 Chaiana Esmeraldino Mendes Marcon, Aline Daiane Schlindwein, Fabiana Schuelter-Trevisol
Introduction: Human immunodeficiency virus (HIV) infection, the etiological agent of acquired immunodeficiency syndrome (AIDS), is a serious public health issue. Therapeutic measures have been successful in increasing the survival and improving the quality of life. However, some treatment-naive subjects living with HIV present resistance-associated mutations as a result of late diagnosis and/or mutant
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MIR-29A-3P, MIR-29C-3P, MIR-146B-5P AND MIR-150-5P, Their Target Genes and Lncrnas in HIV Infection: A Bioinformatic Study Curr. HIV Res. (IF 1.0) Pub Date : 2023-06-13 Maria Rosaria Tumolo, Egeria Scoditti, Roberto Guarino, Tiziana Grassi, Francesco Bagordo, Saverio Sabina
Introduction: Increasing evidence suggests that microRNAs (miRNAs) and long noncoding RNAs (lncRNAs) have emerged as attractive targets in viral infections, including Human immunodeficiency virus (HIV). Objective: To deepen the understanding of the molecular mechanisms that lead to HIV and provide potential targets for the future development of molecular therapies for its treatment. Methods: Four miRNAs
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Intrinsic Apoptotic Pathway Genes of Circulating Blood Neutrophils Triggered during HIV Infection and Remained Stimulated in ART Patients Curr. HIV Res. (IF 1.0) Pub Date : 2023-06-13 A K M Muraduzzaman, Nabeela Mahboob Islam, Shahina Tabassum, Saif Ullah Munshi
Background: The intrinsic apoptotic pathway of neutrophils in Human Immunodeficiency Virus (HIV) infection results in spontaneous neutrophil death. There is a scarcity of data regarding the gene expression of an intrinsic apoptotic pathway of neutrophils in HIV patients. Objective: The objective of this study was to observe the differential expression of some important genes involved in the intrinsic
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Alkaloids as Potential anti-HIV agents Curr. HIV Res. (IF 1.0) Pub Date : 2023-06-09 Nidhi Rani, Randhir Singh, Praveen Kumar, Prerna Sharma, Rajwinder Kaur, Rashmi Arora, Thakur Gurjeet Singh
Background: Alkaloids are nitrogen-containing compounds that are naturally occurring and have a variety of biological activities, including antimicrobial properties. In this study, the authors used a molecular docking approach to evaluate the anti-HIV potential of 64 alkaloids. Methods: The authors used the Molergo Virtual Blocker software to dock the alkaloids into the active sites of three HIV enzymes:
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Adenovirus 36 Coinfection in People Living with HIV and its Impact on Lipohypertrophy Curr. HIV Res. (IF 1.0) Pub Date : 2023-05-22 Helena Caetano Gonçalves e Silva, Jaime Fernandes da Silva, Ana Carolina Lobor Cancelier, Daisson José Trevisol, Thiago Mamôru Sakae, Richard L. Atkinson, Fabiana Schuelter Trevisol
Background: Previous studies have implicated human adenovirus 36 (Adv36) as a potential contributor to overweight and obesity. People living with HIV have an altered body composition compared to healthy individuals. There is still no evidence to confirm the relationship of Adv36 as one of the causes of lipohypertrophy. The main objective of this study was to verify the viral Adv36 infection as a factor
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Long-term Survival Analysis of 30 Maintenance Hemodialysis Pa-tients with HIV infection in a Single-center in China Curr. HIV Res. (IF 1.0) Pub Date : 2023-05-03 Guiju Gao, Wenwen Ren, Yajuan Fang, Tongtong Wang, Chunyu Zhu, Jiang Xiao, Fang Wang, Liang Ni, Di Yang
Background: Maintenance hemodialysis (MHD) patients with HIV infection have a high mortality rate. A number of factors influence the survival rate of these patients. Objectives: Our aim was to determine the risk factors of survival time of MHD patients with HIV. Methods: 30 MHD patients with HIV were retrospectively investigated. The cases were divided into two groups predicated on the dialysis time
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Monoclonal CCR5 Antibody: A Promising Therapy for HIV Curr. HIV Res. (IF 1.0) Pub Date : 2023-03-28 Li Zhao, Yu Lai
HIV is one of the world's most devastating viral infections and has claimed tens of millions of lives worldwide since it was first identified in the 1980s. There is no cure for HIV infection. However, with tremendous progress in HIV diagnosis, prevention, and treatment, HIV has become a manageable chronic health disease. CCR5 is an important coreceptor used by HIV to infect target cells, and genetic
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Point-of-Care HIV Test for a Promising Simple and Rapid Clinical HIV Definite Diagnosis Process Curr. HIV Res. (IF 1.0) Pub Date : 2023-03-28 Zhenrui Xue, Min Song, Ping Peng, Chunyan Yao
Background: This study compared and evaluated the performance of a commercially available HIV POC rapid test with assays commonly used in clinical laboratories, including enzymelinked immunosorbent assay (ELISA), western blot (WB), and reverse transcription-polymerase chain reaction (RT-PCR). Methods: 500 patients’ samples were detected by the POC rapid test and clinically common tests (WB, ELISA,
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An Observational Study of Genetic Diversity of HIV-1 vpu in Rapid Progressors in India Curr. HIV Res. (IF 1.0) Pub Date : 2023-03-08 Poonam Gupta, Arvind Rai, Charoo Hans, Mohammad Husain
Background: The genetic diversity in HIV-1 genes affects viral pathogenesis in HIV-1 positive patients. Accessory genes of HIV-1, including vpu, are reported to play a critical role in HIV pathogenesis and disease progression. Vpu has a crucial role in CD4 degradation and virus release. The sequence heterogeneity in the vpu gene may affect disease progression in patients, therefore, the current study
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Effects of Perceived Social Support on Health-related Quality of Life in Asymptomatic and Symptomatic People Living with HIV in China: A Cross-sectional Study Curr. HIV Res. (IF 1.0) Pub Date : 2023-02-22 Meilian Xie, Aiping Wang, Kerong Wang, Yanping Yu, Zhaoxia Lin
Objective: Improving health-related quality of life (HRQOL) in people living with HIV (PLWH) is one of the critical goals of HIV prevention and control in the following decades, and perceived social support (PSS) has always exhibited a positive influence on patients' HRQOL. This study aims to describe the gap in social support in improving HRQOL between symptomatic and asymptomatic PLWH. Methods: By
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Survival of Persons Living With HIV/AIDS: A Multicentric Study From India Curr. HIV Res. (IF 1.0) Pub Date : 2023-02-22 Sanjeev Sinha, Sameer Abdul Samad, Garima Bansal, Saurav Verma, Shashikala Anant Sangle, Subhasish Kamal Guha, Neetu Rajput, Ravindra Mohan Pandey, Sanjay Ranjan, Sonali Salvi, Sanjay Mundhe, Monika More, Dolanchampa Modak, Kalpana Datta, S.K Kabra, Rakesh Lodha, Neeraj Nischal, Bimal Kumar Das
Background: It has been more than 17 years since the introduction of free ART in India. At this point, it would be prudent to look at the factors associated with the survival of persons living with human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) (PLHA) who are already enrolled in the ART program. Methods: PLHAs enrolled from antiretroviral therapy (ART) centers located
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An Observational Study on HIV and Syphilis Rates and Associated Risk Factors among Elderly Men in Wuxi, China Curr. HIV Res. (IF 1.0) Pub Date : 2023-02-14 Hao Huang, Yuxin Cao, Min Li, Yining Bao, Sarah Robbins, Minjie Chu, Jing Gu, Xiaojun Meng, Xun Zhuang
Background: Acquired Immune Deficiency Syndrome (AIDS) remains a nationwide health problem in China; there were a reported 1,045,000 people living with Human immunodeficiency virus (HIV)/AIDS by the end of October 2020, and the proportion of individuals aged 50 years and older living with HIV has also increased from 8% to 24% over the past two decades. Methods: A cross-sectional study and an 1:2 matched
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Statistical Inferences of HIVRNA and Fracture Based on the PAK1 Expression via Neural Network Model Curr. HIV Res. (IF 1.0) Pub Date : 2023-01-31 Zheng Yuan, Rui Ma, Qiang Zhang, Chang-song Zhao
Background: Acquired immune deficiency syndrome and fracture are all serious hazards to human health that create a widespread alarm. Biomarkers that are closely linked to HIVRNA and fracture are unknown. Methods: 48 cases with HIV and fracture and 112 normal cases were recruited. Blood neutrophil count (NEU), white blood cell count (WBC), PAK1 and HIVRNA were measured. Pearson's chisquared test was
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Epidemiological and Clinical Profile of Newly Diagnosed HIV/AIDS Patients: A Retrospective Analysis of Changing Trends Over 16 Years Curr. HIV Res. (IF 1.0) Pub Date : 2023-01-31 Esra Zerdali, Inci Yilmaz Nakir, Uğurcan Sayili, Serkan Sürme, Mustafa Yildırım
Objective: To evaluate the epidemiological profile and clinical findings of newly diagnosed HIV-infected patients in terms of changing trends over 16 years. Methods: A total of 748 patients (mean ± SD age: 34 ± 11.6 years, 88.9% were males) newly diagnosed with HIV/AIDS at a tertiary care hospital located in Istanbul province between 2002 and 2017 were included in this retrospective study. Data on
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Determination of Serum Differential Carnitine Ester Levels in HIV(+) Patients: A Cross-sectional Study Curr. HIV Res. (IF 1.0) Pub Date : 2023-01-18 Irfan Binici, Halil İbrahim Akbay, Zübeyir Huyut, Hamit Hakan Alp, Hasan Karsen, Ismail Koyuncu, Ataman Gonel, Şükrü Akmeşe, Hakim Çelik
Objective: It has been reported that carnitine deficiency is observed in various viral infections and in the follow-up of the prognosis of some diseases. In this cross-sectional study, we aimed to determine how carnitine ester derivatives change in HIV-positive patients. Materials and Methods: In this study, 25 HIV-infected patients who applied to Harran University Faculty of Medicine Education Research
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Better Predictive Value of Lymphocyte Count and Hemoglobin for CD4 Level of HIV Patients Curr. HIV Res. (IF 1.0) Pub Date : 2023-01-18 Zheng-Rong Gao, Zheng Yuan, Chang-song Zhao, Ru-gang Zhao, Qiang Zhang
Objective: HIV patients are prone to infection and difficult to treat, which mainly manifests itself in decreased CD4+ T cells in the body. Therefore, the predictive value of lymphocyte count and hemoglobin for CD4+ levels in HIV patients was discussed in the prospective study. Methods: 1125 HIV patients (aged >18 or < 80 years) were recruited. Pearson chi-square test was used to explore the correlation
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Willingness to Recommend Pre-Exposure Prophylaxis for HIV Prevention Among Mexican Non-Physician Health Providers: A Cross-Sectional Study Curr. HIV Res. (IF 1.0) Pub Date : 2022-12-29 Dulce María Díaz-Sosa, Centli Guillen-Díaz-Barriga, Rebeca Robles-García, Hamid Vega-Ramírez
Background: Pre-exposure prophylaxis (PrEP) has recently been introduced in Mexico. Still, there are no data exploring the frequency and related factors of willingness to recommend it among non-physician health providers (Non-PHP). Objective: Compare awareness, knowledge, attitudes, and willingness to recommend PrEP and combined HIV prevention among Mexican non-PHP. Methods: We conducted an online
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Effect of Non-Surgical Periodontal Therapy on Clinical Parameters of Periodontitis, Oral Candida spp. Count and Lactoferrin and Histatin Expression in Saliva and Gingival Crevicular Fluid of HIV-Infected Patients Curr. HIV Res. (IF 1.0) Pub Date : 2022-12-29 Atila V. V. Nobre, Tabata L. S. Polvora, Diana E. Ramos Peña, Kelly V. Villafuerte, Gilberto A. Silva, Ana Laura P. Ranieri, Leandro D. de Macedo, Karen M. L. Morejon, Benedito A. L. da Fonseca, Camila Tirapelli, Maria C. P. Saraiva, Bruno Pozzetto, Alan G. Lourenço, Ana Carolina F. Motta
Background: Periodontitis (PDT) has gained attention in the literature with the increase in life expectancy of people living with HIV on combined antiretroviral therapy (cART). Thus, the search for inflammatory biomarkers could be useful to understand the pathophysiology of chronic oral diseases in the cART era. Objective: The aim of this study was to evaluate the impact of non-surgical periodontal
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Cervical Cytology and Herpes Simplex Virus Type-2 Serology Among Human Immune Deficiency Virus Infected Women on Highly Active Antiretroviral Therapy in Enugu, Nigeria Curr. HIV Res. (IF 1.0) Pub Date : 2022-11-21 Cornelius Osinachi Ogu, Peter Uwadiegwu Achukwu, Peter Onubiwe Nkwo, Rita Ifeoma-Ossy Ogu, Okechukwu Steven Onwukwe, Nkiruka Chinonye Azubuike, Anulika Obianuju Onyemelukwe, Ijeoma Maryjoy Ifeorah, Maduakor Charity Uzoamaka
Background: The prevalence of Human Immunodeficiency Virus (HIV) and Herpes Simplex Virus type-2 (HSV-2) infections are high and the programme for Cervical Cancer Screening is weak in Nigeria. Objectives: Prevalence of Herpes Simplex Virus Type-2 co-infection and cervical cytology among HSV-2 co-infected Human Immunodeficiency Virus Sero-positive (HIV+) women on Highly Active Antiretroviral Therapy
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Identification of a New HIV-1 Circulating Recombinant Form CRF112_01B Strain in Baoding City, Hebei Province, China Curr. HIV Res. (IF 1.0) Pub Date : 2022-11-15 Hao Wang, Xuanhe Zhao, Miaomiao Su, Juan Meng, Weiguang Fan, Penghui Shi
Background: A large number of HIV-1 recombinants that originated from CRF01_AE and B strains are constantly emerging in men who have sex with men populations in China and deserve more attention and further monitoring. Objective: To analyze the near-full-length genome structure and recombination characteristics of a new HIV-1 strain (BD226AJ) detected in Baoding City and determine its subtype. Case
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SARS-CoV-2/COVID-19: Clinical Course Among Subjects HIV-1-Infected in Sao Paulo Curr. HIV Res. (IF 1.0) Pub Date : 2022-11-02 Mariana A. Monteiro, Gabriela S. Prates, Najara A. de Lima Nascimento, Ana Paula R. Veiga, Marcello M.C. Magri, Thales J.B. Polis, Maria R.P. Gascon, Mauricio D. Ferreira, Larissa Tiberto, Luisa O. Pereira, Wagner Alves, Luiz A.M. Fonseca, Alberto J.S. Duarte, Jorge Casseb
Introduction: People living with Human Immunodeficiency Virus (HIV) are under risk for co-infection with SARS-CoV-2. This population may be more prone to complications from COVID-19 due to persistent inflammation caused by HIV and higher incidence of metabolic syndromes, cardiovascular diseases, and malignancies, as well as being considered elderly at 50 years of age. The objective of this study was
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Serum Interleukin-6 and Weight Loss in Antiretroviral-naïve and Antiretroviral-treated Patients with HIV/AIDS: Relationships and Predictors Curr. HIV Res. (IF 1.0) Pub Date : 2022-11-02 Tewogbade Adeoye Adedeji, Nife Olamide Adedeji, Abiodun Kofoworola Ajeigbe, Olufemi Samuel Smith, Olusola Akanni Jeje, Michael Bimbo Fawale, Abiodun Olabamiji Ajose, Simeon Adelani Adebisi, Adeyinka Abdulrasak Akande, Bashiru Adekunle Okesina
Background: Cachexia is usually associated with elevated serum interleukin-6 (IL6) as it stimulates the breakdown of muscle proteins and promotes wasting. Objective: A case-control study to evaluate the relationship between weight loss, facial fat loss, and IL-6 in antiretroviral-naïve and treated participants living with HIV/AIDS. Methods: IL-6 was assayed by High performance liquid chromatography
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A Case of Spontaneous Mediastinal and Subcutaneous Emphysema in a Patient with HIV-Infected Pneumonia Curr. HIV Res. (IF 1.0) Pub Date : 2022-10-20 Jun-Chen Li, Gang Nie, Hai-Feng Dai
Background: Acquired immunodeficiency syndrome is a chronic infectious disease with high mortality and is caused by the Human Immunodeficiency Virus (HIV). Pneumonia caused by HIV is common, but it rarely causes spontaneous mediastinal and subcutaneous emphysema. Case Presentation: A 21-year-old man with severe pneumonia was hospitalized owing to dyspnea that had been persisting for 1 day; blood test