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Danhongqing formula alleviates cholestatic liver fibrosis by downregulating long non-coding RNA H19 derived from cholangiocytes and inhibiting hepatic stellate cell activation J. Integr. Med. (IF 4.8) Pub Date : 2024-03-09 Meng Li, Yang Zhou, Hui Zhu, Lie-ming Xu, Jian Ping
This study explores the mechanism of action of Danhongqing formula (DHQ), a compound-based Chinese medicine formula, in the treatment of cholestatic liver fibrosis. In vivo experiments were conducted using 8-week-old knockout () mice as an animal model of cholestatic liver fibrosis. DHQ was administered orally for 8 weeks, and its impact on cholestatic liver fibrosis was evaluated by assessing liver
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The acceptance of traditional Chinese medicine among patients with Parkinson’s disease: A hospital survey J. Integr. Med. (IF 4.8) Pub Date : 2024-03-08 Peng Wang, Jing Hong, Zhu-qian Tang, Bi-zhen Gong, Xiao-rong Qi, Han Jiang, Bo Pan, Qi Chen
The efficacy of medications for Parkinson’s disease (PD) tend to decline over time, which has a serious impact on patients’ health and quality of life. To some extent, traditional Chinese medicine (TCM) can resolve the distressing problem of ineffective dopaminergic medication in PD patients. The purpose of this study was to investigate the attitude, acceptance, and independent predictors of TCM in
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Cordyceps as potential therapeutic agents for atherosclerosis J. Integr. Med. (IF 4.8) Pub Date : 2024-03-07 Yi Zhang, Si-jing Liu
Atherosclerosis is a leading cause of mortality and morbidity worldwide. Despite the challenges in managing atherosclerosis, researchers continue to investigate new treatments and complementary therapies. Cordyceps is a traditional Chinese medicine that has recently gained attention as a potential therapeutic agent for atherosclerosis. Numerous studies have demonstrated the effectiveness of cordyceps
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Chinese herbal medicine Ginkgo biloba L. preparations for ischemic stroke: An overview of systematic reviews and meta-analyses J. Integr. Med. (IF 4.8) Pub Date : 2024-03-06 Tian-tian Meng, Ya-ping You, Min Li, Jian-bo Guo, Xin-bin Song, Jing-yi Ding, Xiao-long Xie, An-qi Li, Shang-jin Li, Xiang-jun Yin, Peng Wang, Zhe Wang, Bao-liang Wang, Qing-yong He
L. preparations (GBLPs) are a class of Chinese herbal medicine used in the adjuvant treatment of ischemic stroke (IS). Recently, several systematic reviews (SRs) and meta-analyses (MAs) of GBLPs for IS have been published. This overview aims to assess the quality of related SRs and MAs. Twenty-nine SRs/MAs involving 119 outcomes were included in this review. The overall methodological quality of all
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Efficacy of acupuncture on cancer pain: A systematic review and meta-analysis J. Integr. Med. (IF 4.8) Pub Date : 2024-03-06 Miguel Faria, Mónica Teixeira, Maria João Pinto, Paulo Sargento
Pain associated with cancer is one of the greatest causes of reduced quality of life in patients. Acupuncture is one of the treatments used to address this issue, with the great advantage of having little or no side effects, especially when compared with pharmacological pain-killers. The aim of this systematic review and meta-analysis was to evaluate the current evidence regarding the efficacy of acupuncture
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Acupuncture for obesity and related diseases: insight for regulating neural circuit J. Integr. Med. (IF 4.8) Pub Date : 2024-03-06 Lin-yan Jiang, Jun Tian, Ya-nan Yang, Shao-hui Jia, Qing Shu
Obesity is defined as abnormal or excessive fat accumulation that may impair health. Obesity is associated with numerous pathological changes including insulin resistance, fatty liver, hyperlipidemias, and other obesity-related diseases. These comorbidities comprise a significant public health threat. Existing anti-obesity drugs have been limited by side effects that include depression, suicidal thoughts
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Chrononutrition in traditional European medicine—ideal meal timing for cardiometabolic health promotion J. Integr. Med. (IF 4.8) Pub Date : 2024-03-01 Nora Selena Eberli, Ludivine Colas, Anne Gimalac
Meal timing plays a crucial role for cardiometabolic health, given the circadian regulation of cardiometabolic function. However, to the best of our knowledge, no concept of meal timing exists in traditional European medicine (TEM). Therefore, in this narrative review, we aim to define the optimal time slot for energy intake and optimal energy distribution throughout the day in a context of TEM and
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Herbal compounds as promising therapeutic agents in precision medicine strategies for cancer: A systematic review J. Integr. Med. (IF 4.8) Pub Date : 2024-02-28 Bizhar Ahmed Tayeb, Ikhwan Yuda Kusuma, Alaa A.M. Osman, Renáta Minorics
The field of personalized medicine has gained increasing attention in cancer care, with the aim of tailoring treatment strategies to individual patients for improved outcomes. Herbal medicine, with its long-standing historical use and extensive bioactive compounds, offers a rich source of potential treatments for various diseases, including cancer. To provide an overview of the current knowledge and
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Associations between the use of red yeast rice preparations and adverse health outcomes: An umbrella review of meta-analyses of randomized controlled trials J. Integr. Med. (IF 4.8) Pub Date : 2024-02-02 Zhen-yu Ma, Shu-ping Yang, Ying Li, Tian-tian Xu, Ya-lin Yang, Hui-yong Yang, Heng-bing Li, Le-jin Zhou, Yong Diao, Su-yun Li
Background Red yeast rice (RYR), a natural lipid-lowering agent, is widely used in clinical practice. However, the existing meta-analyses concerning the safety of RYR preparations have yielded inconsistent results, and the credibility of the evidence has not been quantified. Objective This study was designed to evaluate the existing evidence and offer a comprehensive understanding of the associations
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Predictors of the placebo response in a nutraceutical randomized controlled trial for depression J. Integr. Med. (IF 4.8) Pub Date : 2024-01-24 Rosemary Arnold, Jenifer Murphy-Smith, Chee H. Ng, David Mischoulon, Gerard J. Byrne, Chad A. Bousman, Con Stough, Michael Berk, Jerome Sarris
The placebo response in depression studies is the change in symptoms amongst those who receive an inactive treatment. Many well-designed randomized controlled trials (RCTs) of depression have a high proportion of placebo responders, with little understanding as to why. The present study assesses characteristics associated with the placebo response in a nutraceutical trial with a large proportion of
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Transcutaneous electrical acupoint stimulation benefits postoperative pain relief of oocyte retrieval: A randomized controlled trial J. Integr. Med. (IF 4.8) Pub Date : 2024-01-24 Li-ying Liu, Yang Su, Rong-rong Wang, Yuan-yuan Lai, Lei Huang, Yi-ting Li, Xin-yue Tao, Meng-hua Su, Xiao-yan Zheng, Shi-chen Huang, Yong-na Wu, Si-yi Yu, Fan-rong Liang, Jie Yang
Transvaginal oocyte retrieval is frequently followed by adverse events related to anesthesia and the procedure. Some research showed that transcutaneous electrical acupoint stimulation (TEAS) can relieve intraoperative pain and postoperative nausea. This study examined whether TEAS can alleviate pain and relieve adverse symptoms after oocyte retrieval. Altogether 128 patients were randomly divided
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Alisol B 23-acetate promotes white adipose tissue browning to mitigate high-fat diet-induced obesity by regulating mTOR-SREBP1 signaling J. Integr. Med. (IF 4.8) Pub Date : 2024-01-24 Lu-lu Han, Xin Zhang, Hui Zhang, Ting Li, Yi-chen Zhao, Ming-hui Tian, Feng-lei Sun, Bo Feng
Obesity is a global health concern with management strategies encompassing bariatric surgery and anti-obesity drugs; however, concerns regarding complexities and side effects persist, driving research for more effective, low-risk strategies. The promotion of white adipose tissue (WAT) browning has emerged as a promising approach. Moreover, alisol B 23-acetate (AB23A) has demonstrated efficacy in addressing
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Short-term effects of cupping and scraping therapy for chronic nonspecific low-back pain: A prospective, multicenter randomized trial J. Integr. Med. (IF 4.8) Pub Date : 2024-01-24 Jun-yan He, Xiao-yu Tu, Zi-fei Yin, Hui Mu, Ming-jun Luo, Xing-yu Chen, Wei-bin Cai, Xue Zhao, Can Peng, Fan-fu Fang, Can Lü, Bai Li
As one of the most common musculoskeletal ailments, chronic nonspecific low-back pain (CNLBP) causes persistent disability and substantial medical expenses. Epidemiological evidence shows that the incidence rate of CNLBP in young and middle-aged people who are demanded rapidly recovery and social contribution is rising. Recent guidelines indicate a reduced role for medicines in the management of CNLBP
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Identifying behavioral determinants and stage of readiness for performing knee massage among individuals with knee osteoarthritis: An observational study J. Integr. Med. (IF 4.8) Pub Date : 2024-01-24 Donya Nemati, Niki Munk, Navin Kaushal
Patients who experience knee osteoarthritis or chronic knee pain can alleviate their symptoms by performing self-knee massage. Understanding the readiness and types of determinants needed to facilitate self-knee massage is needed to design effective, theory-informed interventions. The primary objective of this study was to apply the transtheoretical model of behavior change to identify how factors
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Tocotrienol isoforms: The molecular mechanisms underlying their effects in cancer therapy and their implementation in clinical trials J. Integr. Med. (IF 4.8) Pub Date : 2024-01-18 Maria Younes, Ghady Loubnane, Christopher Sleiman, Sandra Rizk
Tocotrienols are found in a variety of natural sources, like rice bran, annatto seeds and palm oil, and have been shown to have several health-promoting properties, particularly against chronic diseases such as cancer. The incidence of cancer is rapidly increasing around the world, not only a result of continued aging and population growth, but also due to the adoption of aspects of the Western lifestyle
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Melittin analog p5RHH enhances recombinant adeno-associated virus transduction efficiency J. Integr. Med. (IF 4.8) Pub Date : 2024-01-17 Jing-shun Meng, Yun He, Heng-bin Yang, Li-ping Zhou, Si-yuan Wang, Xi-lin Feng, Omar Yahya Al-shargi, Xiao-min Yu, Li-qing Zhu, Chang-quan Ling
Melittin and its derivative have been developed to support effective gene delivery systems. Their ability to facilitate endosomal release enhances the delivery of nanoparticle-based gene therapy. Nevertheless, its potential application in the context of viral vectors has not received much attention. Therefore, we would like to optimize the rAAV vector by Melittin analog to improve the transduction
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Mapping the clinical practice of traditional, complementary and integrative medicine in oncology in Western countries: A multinational cross-sectional survey J. Integr. Med. (IF 4.8) Pub Date : 2023-12-28 Matthias Huemer, Sandro Graca, Sarah Bitsche, Guenter Hofmann, Mike Armour, Martin Pichler
Many cancer patients seek adjunctive therapies to biomedical cancer treatments at some point of their disease trajectory. While acupuncture is increasingly recommended by leading oncological associations, limited evidence exists concerning the evidence-informed practice and adherence to current guidelines of traditional complementary and integrative medicine (TCIM) practitioners treating cancer patients
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Acupuncture and moxibustion for irritable bowel syndrome: An umbrella systematic review J. Integr. Med. (IF 4.8) Pub Date : 2023-12-23 Yue-ying Ma, Zhou Hao, Zi-yi Chen, Yan-xi Shen, Hui-rong Liu, Huan-gan Wu, Chun-hui Bao
Irritable bowel syndrome (IBS) is a functional bowel disease characterized by abdominal pain or discomfort associated with altered bowel habits. Several clinical studies have demonstrated the effectiveness of acupuncture and moxibustion for IBS. Many systematic reviews of acupuncture and moxibustion for IBS have been published in recent years, but their results are not entirely consistent. To evaluate
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Efficacy of scraping therapy on blood pressure and sleep quality in stage I and II essential hypertension: A systematic review and meta-analysis J. Integr. Med. (IF 4.8) Pub Date : 2023-11-25 Zheng-gang Zhu, Jian-ru Wang, Xiao-yan Pan
Scraping therapy is widely used in treating stage I and II essential hypertension in China. However, there has been no systematic evaluation of the efficacy of scraping therapy on blood pressure and sleep quality in stage I and II essential hypertension. Seven electronic databases (PubMed, Scopus, Cochrane Library, Web of Science, EBSCO, China National Knowledge Infrastructure and Wanfang Data electronic
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Anti-inflammatory effects of acupuncture in the treatment of chronic obstructive pulmonary disease J. Integr. Med. (IF 4.8) Pub Date : 2023-11-14 Lin-hong Jiang, Pei-jun Li, Ying-qi Wang, Mei-ling Jiang, Xiao-yu Han, Yi-die Bao, Xin-liao Deng, Wei-bing Wu, Xiao-dan Liu
Numerous randomised controlled trials have suggested the positive effects of acupuncture on chronic obstructive pulmonary disease (COPD). However, the underlying therapeutic mechanisms of acupuncture for COPD have not been clearly summarized yet. Inflammation is central to the development of COPD. In this review, we elucidate the effects and underlying mechanisms of acupuncture from an anti-inflammatory
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Ethanol extract of Herpetospermum caudigerum Wall ameliorates psoriasis-like skin inflammation and promotes degradation of keratinocyte-derived ICAM-1 and CXCL9 J. Integr. Med. (IF 4.8) Pub Date : 2023-11-11 Ya Zhong, Bo-wen Zhang, Jin-tao Li, Xin Zeng, Jun-xia Pei, Ya-mei Zhang, Yi-xi Yang, Fu-lun Li, Yu Deng, Qi Zhao
Objective To explore whether the ethanol extract of Herpetospermum caudigerum Wall (EHC), a Xizang medicinal plant traditionally used for treating liver diseases, can improve imiquimod-induced psoriasis-like skin inflammation. Methods Immunohistochemistry and immunofluorescence staining were used to determine the effects of topical EHC use in vivo on the skin pathology of imiquimod-induced psoriasis
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Efficacy and safety of Kangxian Huanji Granule as adjunctive treatment in acute exacerbation of idiopathic pulmonary fibrosis: An exploratory randomized controlled trial J. Integr. Med. (IF 4.8) Pub Date : 2023-11-08 Jian-sheng Li, Hai-long Zhang, Wen Guo, Lu Wang, Dong Zhang, Li-min Zhao, Miao Zhou
Background Acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF) is an important occurrence in the natural history of idiopathic pulmonary fibrosis (IPF), associated with high hospitalization rates, high mortality and poor prognosis. At present, there is no effective treatment for AE-IPF. Chinese herbal medicine has some advantages in treating IPF, but its utility in AE-IPF is unclear. Objective
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Xiaotan Sanjie recipe, a compound Chinese herbal medicine, inhibits gastric cancer metastasis by regulating GnT-V-mediated E-cadherin glycosylation J. Integr. Med. (IF 4.8) Pub Date : 2023-11-07 Nian Huang, Hai-wei He, Yu-yu He, Wei Gu, Ming-juan Xu, Long Liu
Objective Xiaotan Sanjie recipe (XTSJ), a Chinese herbal compound medicine, exerts a significant inhibitory effect on gastric cancer (GC) metastasis. This work investigated the mechanism underlying the XTSJ-mediated inhibition of GC metastasis. Methods The effect of XTSJ on GC metastasis and the associated mechanism were investigated in vitro, using GC cell lines, and in vivo, using a GC mouse model
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A clinical pathway for integrative medicine in the treatment of functional constipation in Hong Kong, China J. Integr. Med. (IF 4.8) Pub Date : 2023-11-07 Dong-jue Wei, Hui-juan Li, Zi-pan Lyu, Ai-ping Lyu, Zhao-xiang Bian, Linda LD Zhong
Objective Functional constipation (FC) is a common intestinal disease worldwide. Despite the presence of criteria such as Roman IV, there is no standardized diagnosis and treatment algorithm in Hong Kong that combines both Western and Chinese medicine approaches. This study integrates current effective and safe diagnosis and treatment methods for FC and provides a clear and scientific pathway for clinical
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Electroacupuncture for abdominal pain relief in patients with acute pancreatitis: A three-arm randomized controlled trial J. Integr. Med. (IF 4.8) Pub Date : 2023-11-02 Dong Kee Jang, Jun Kyu Lee, Chan Yung Jung, Kyung Ho Kim, Ha Ra Kang, Yeon Sun Lee, Jong Hwa Yoon, Kwang Ro Joo, Min Kyu Chae, Yong Hyeon Baek, Byung-Kwan Seo, Sang Hyub Lee, Chiyeon Lim
Background Electroacupuncture (EA) may reduce the severity of acute pancreatitis (AP) and provide additional pain relief in patients with chronic pancreatitis. However, the ability of EA to relieve pain in patients with AP has not been well documented. Objective This study was undertaken to compare the pain-relieving effects of EA and conventional treatment in patients with AP. Design, setting, participants
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Blinding assessment in clinical trials of traditional Chinese medicine: Exploratory principles and protocol J. Integr. Med. (IF 4.8) Pub Date : 2023-10-29 Xiao-cong Wang, Xiao-yu Liu, Kang-le Shi, Qing-gang Meng, Yue-fan Yu, Shi-yao Wang, Juan Wang, Chang Qu, Cong Lei, Xin-ping Yu
As one of the key components of clinical trials, blinding, if successfully implemented, can help to mitigate the risks of implementation bias and measurement bias, consequently improving the validity and reliability of the trial results. However, successful blinding in clinical trials of traditional Chinese medicine (TCM) is hard to achieve, and the evaluation of blinding success through blinding assessment
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Aconite aqueous extract inhibits the growth of hepatocellular carcinoma through CCL2-dependent enhancement of natural killer cell infiltration J. Integr. Med. (IF 4.8) Pub Date : 2023-10-29 Kang-di Yang, Xu Zhang, Ming-cong Shao, Li-na Wang
Objective Aconite is a traditional Chinese herbal medicine that has been found to inhibit the development of liver cancer; however, its exact molecular mechanisms in this process remain unclear. This study explores how aconite aqueous extract (AAE) inhibits hepatocellular carcinoma (HCC). Methods An in vivo mouse model of subcutaneous liver cancer was established. After AAE treatment, immunohistochemistry
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Promoting whole person health: Exploring the role of traditional Chinese medicine in Polish healthcare J. Integr. Med. (IF 4.8) Pub Date : 2023-10-19 Monika Rybicka, Jing Zhao, Karolina Piotrowicz, Sara Ptasnik, Kamila Mitka, Magdalena Kocot-Kępska, Ka-Kit Hui
Poland has a unique history of traditional Chinese medicine (TCM) dating back to the 17th century when Polish missionary Michael (Michał) Boym was a pioneer in the field. In the 20th century, his successor, Professor Zbigniew Garnuszewski, reintroduced acupuncture to medical practice in Poland. However, other methods of TCM and its holistic approach to patient care have not found their place in modern
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Herbal combinations against COVID-19: A network pharmacology, molecular docking and dynamics study J. Integr. Med. (IF 4.8) Pub Date : 2023-09-26 Jian-bo Song, Li-qin Zhao, Hong-ping Wen, Yuan-ping Li
Objective The aim of this study is to identify molecules from traditional Chinese medicine (TCM) with potential activity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its variants. Methods We applied the Apriori algorithm to identify important combinations of herbs in the TCM prescriptions for the treatment of coronavirus disease 2019 (COVID-19). Then, we explored the active
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Effects of hyperbaric oxygen therapy on human psychomotor performance: A review J. Integr. Med. (IF 4.8) Pub Date : 2023-08-20 Dorota Olex-Zarychta
Psychomotor performance is the coordination of a sensory or ideational (cognitive) process and a motor activity. All sensorimotor processes involved in planning and execution of voluntary movements need oxygen supply and seem to be significantly disrupted in states of hypoxia. Hyperbaric oxygen therapy has become a widely used treatment in routine medicine and sport medicine due to its beneficial effects
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Xuebijing injection, a Chinese patent medicine, against severe pneumonia: Current research progress and future perspectives J. Integr. Med. (IF 4.8) Pub Date : 2023-08-11 Mei Zhang, Rui Zheng, Wen-jing Liu, Jun-ling Hou, Yu-lei Yang, Hong-cai Shang
Severe pneumonia is one of the most common infectious diseases and the leading cause of sepsis and septic shock. Preventing infection, balancing the patient’s immune status, and anti-coagulation therapy are all important elements in the treatment of severe pneumonia. As multi-target agents, Xuebijing injection (XBJ) has shown unique advantages in targeting complex conditions and saving the lives of
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Placebo response of sham acupuncture in patients with primary dysmenorrhea: A meta-analysis J. Integr. Med. (IF 4.8) Pub Date : 2023-08-11 Chong-yang Sun, Zhi-yi Xiong, Cheng-yi Sun, Pei-hong Ma, Xiao-yu Liu, Chi-yun Sun, Ze-yin Xin, Bao-yan Liu, Cun-zhi Liu, Shi-yan Yan
Background The placebo response of sham acupuncture in patients with primary dysmenorrhea is a substantial factor associated with analgesia. However, the magnitude of the placebo response is unclear. Objective This meta-analysis assessed the effects of sham acupuncture in patients with primary dysmenorrhea and the factors contributing to these effects. Search strategy PubMed, Embase, Web of Science
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Sulforaphane, an NRF2 agonist, alleviates ferroptosis in acute liver failure by regulating HDAC6 activity J. Integr. Med. (IF 4.8) Pub Date : 2023-08-09 Yan-qiong Zhang, Chun-xia Shi, Dan-mei Zhang, Lu-yi Zhang, Lu-wen Wang, Zuo-jiong Gong
Objective Acute liver failure (ALF) is characterized by severe liver dysfunction, rapid progression and high mortality and is difficult to treat. Studies have found that sulforaphane (SFN), a nuclear factor E2-related factor 2 (NRF2) agonist, has anti-inflammatory, antioxidant and anticancer effects, and has certain protective effects on neurodegenerative diseases, cancer and liver fibrosis. This paper
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The role and advantage of traditional Chinese medicine in the prevention and treatment of COVID-19 J. Integr. Med. (IF 4.8) Pub Date : 2023-08-09 Ming Huang, Yao-yuan Liu, Ke Xiong, Feng-wen Yang, Xin-yao Jin, Zhao-qi Wang, Jun-hua Zhang, Bo-li Zhang
The global coronavirus disease 2019 (COVID-19) pandemic has had a massive impact on global social and economic development and human health. By combining traditional Chinese medicine (TCM) with modern medicine, the Chinese government has protected public health by supporting all phases of COVID-19 prevention and treatment, including community prevention, clinical treatment, control of disease progression
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Clinical evidence of three traditional Chinese medicine drugs and three herbal formulas for COVID-19: A systematic review and meta-analysis of the Chinese population J. Integr. Med. (IF 4.8) Pub Date : 2023-08-05 Liang-zhen You, Qian-qian Dai, Xiao-ying Zhong, Dong-dong Yu, He-rong Cui, Yi-fan Kong, Meng-zhu Zhao, Xin-yi Zhang, Qian-qian Xu, Zhi-yue Guan, Xu-xu Wei, Xue-cheng Zhang, Song-jie Han, Wen-jing Liu, Zhao Chen, Xiao-yu Zhang, Chen Zhao, Ying-hui Jin, Hong-cai Shang
Background The coronavirus disease 2019 (COVID-19) continues to spread worldwide. Integrated Chinese and Western medicine have had some successes in treating COVID-19. Objective This study aims to evaluate the efficacy and safety of three traditional Chinese medicine drugs and three herbal formulas (3-drugs-3-formulas) in patients with COVID-19. Search strategy Relevant studies were identified from
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Baicalin, silver titanate, Bletilla striata polysaccharide and carboxymethyl chitosan in a porous sponge dressing for burn wound healing J. Integr. Med. (IF 4.8) Pub Date : 2023-07-25 Yan-rong Gong, Cheng Zhang, Xing Xiang, Zhi-bo Wang, Yu-qing Wang, Yong-hua Su, Hui-qing Zhang
Objective This study tests the efficacy of Bletilla striata polysaccharide (BSP), carboxymethyl chitosan (CMC), baicalin (BA) and silver titanate (ST) in a wound dressings to fight infection, promote healing and provide superior biocompatibility. Methods The antibacterial activity of BA and ST was evaluated in vitro using the inhibition zone method. BA/ST/BSP/CMC porous sponge dressings were prepared
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Electroacupuncture alleviates postoperative pain through inhibiting neuroinflammation via stimulator of interferon genes/type-1 interferon pathway J. Integr. Med. (IF 4.8) Pub Date : 2023-07-05 Yuan-yuan Ding, Feng Xu, Ya-feng Wang, Lin-lin Han, Shi-qian Huang, Shuai Zhao, Lu-lin Ma, Tian-hao Zhang, Wen-jing Zhao, Xiang-dong Chen
Objective This work explores the impact of electroacupuncture (EA) on acute postoperative pain (APP) and the role of stimulator of interferon genes/type-1 interferon (STING/IFN-1) signaling pathway modulation in the analgesic effect of EA in APP rats. Methods The APP rat model was initiated through abdominal surgery and the animals received two 30 min sessions of EA at bilateral ST36 (Zusanli) and
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Jiedu Recipe, a compound Chinese herbal medicine, inhibits cancer stemness in hepatocellular carcinoma via Wnt/β-catenin pathway under hypoxia J. Integr. Med. (IF 4.8) Pub Date : 2023-06-29 Bing-jie Guo, Yi Ruan, Ya-jing Wang, Chu-lan Xiao, Zhi-peng Zhong, Bin-bin Cheng, Juan Du, Bai Li, Wei Gu, Zi-fei Yin
Objective Jiedu Recipe (JR), a Chinese herbal remedy, has been shown to prolong overall survival time and decrease recurrence and metastasis rates in patients with hepatocellular carcinoma (HCC). This work investigated the mechanism of JR in HCC treatment. Methods The chemical constituents of JR were detected using liquid chromatography-mass spectrometry. The potential anti-HCC mechanism of JR was
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From talk to action: Developing a model to foster effective integration of traditional medicine into the Ghanaian healthcare system J. Integr. Med. (IF 4.8) Pub Date : 2023-06-22 Irene G. Ampomah, Bunmi S. Malau-Aduli, Aduli E.O. Malau-Aduli, Theophilus I. Emeto
This research assessed the experience of stakeholders and the efficacy of integrating traditional medicine into the Ghanaian health system using the Ashanti Region as the focal point. Elements of an integrative healthcare delivery model including philosophies/values, structure, process and outcome were used to conduct a quality assessment of the integrated health system in Ghana. Each element clearly
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Phytochemical interventions for post-traumatic stress disorder: A cluster co-occurrence network analysis using CiteSpace J. Integr. Med. (IF 4.8) Pub Date : 2023-06-15 Biao Gao, Yi-cui Qu, Meng-yu Cai, Yin-yin Zhang, Hong-tao Lu, Hong-xia Li, Yu-xiao Tang, Hui Shen
Objective This study investigated trends in the study of phytochemical treatment of post-traumatic stress disorder (PTSD). Methods The Web of Science database (2007–2022) was searched using the search terms “phytochemicals” and “PTSD,” and relevant literature was compiled. Network clustering co-occurrence analysis and qualitative narrative review were conducted. Results Three hundred and one articles
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Reduced SARS-CoV-2 infection risk is associated with the use of Seven-Flavor Herb Tea: A multi-center observational study in Shanghai, China J. Integr. Med. (IF 4.8) Pub Date : 2023-06-14 Shun-Xian Zhang, Xiao-Xu Chen, Yong Zheng, Bing-Hua Cai, Wei Shi, Ming Ru, Hui Li, Dan-Dan Zhang, Yu Tian, Yue-Lai Chen
Objective Omicron, a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant, is responsible for numerous infections in China. This study investigates the association between the use of Seven-Flavor Herb Tea (SFHT) and the risk of SARS-CoV-2 infection to develop precise and differentiated strategies for control of the coronavirus disease 2019 (COVID-19). Methods This case-control study
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Effects of COVID-19 fear and anxiety on attitudes towards complementary and alternative medicine use in women with gynecological cancer during the COVID-19 pandemic J. Integr. Med. (IF 4.8) Pub Date : 2023-06-08 Fatma Uslu-Sahan, Ilknur Yesilcınar, Gonul Kurt, Elif Hancer, Gulten Guvenc
Objective Patients with gynecological cancer commonly use complementary and alternative medicine (CAM) methods to cope with the disease. However, despite the existence of treatment strategies, the effect of fear and anxiety caused by coronavirus disease 2019 (COVID-19) pandemic on attitudes about CAM use is unclear. This study was carried out to investigate the effect of fear and anxiety experienced
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A mathematic equation derived from host-pathogen interactions elucidates the significance of integrating modern medicine with traditional Chinese medicine to treat infectious diseases J. Integr. Med. (IF 4.8) Pub Date : 2023-06-08 Jianjun Sun
The prognosis of infectious diseases is determined by host-pathogen interactions. Control of pathogens has been the central dogma of treating infectious diseases in modern medicine, but the pathogen-directed medicine is facing significant challenges, including a lack of effective antimicrobials for newly emerging pathogens, pathogen drug resistance, and drug side effects. Here, a mathematic equation
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Herbal medicine use in Republic of Korea to alleviate side effects of COVID-19 vaccines: A cross-sectional study J. Integr. Med. (IF 4.8) Pub Date : 2023-06-08 Hae-Chang Yoon
Objective Coronavirus disease 2019 (COVID-19) has spread worldwide, and several virus variants have emerged. Vaccines are administered to help prevent the infection. In Republic of Korea, most people take herbal medicine. This study investigated the use of herbal medicine to counter the side effects of COVID-19 vaccines. Methods This cross-sectional study was conducted using an online survey. Chi-square
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Anti-inflammatory mechanism of electroacupuncture involves the modulation of multiple systems, levels and targets and is not limited to “driving the vagus-adrenal axis” J. Integr. Med. (IF 4.8) Pub Date : 2023-06-07 Arthur Yin Fan
In October 2021, an international collaborative study on the use of electroacupuncture (EA) to treat inflammation was published in the journal Nature by Dr. Qiufu Ma’s team. Based on the results of EA on inflammation in the mouse model of lipopolysaccharide inflammatory storm, the study showed that the distal effect of acupuncture can be achieved by “driving the vagus-adrenal axis (through the adrenal
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Electro-acupuncture promotes gut motility and alleviates functional constipation by regulating gut microbiota and increasing butyric acid generation in mice J. Integr. Med. (IF 4.8) Pub Date : 2023-06-01 Ming-min Xu, Yu Guo, Ying Chen, Wei Zhang, Lu Wang, Ying Li
Objective Abnormalities in the gut microbiota and intestinal short-chain fatty acid (SCFA) levels are implicated in the pathogenesis of functional constipation (FC). Electro-acupuncture (EA) has been shown to improve constipation-related symptoms and rebalance the gut microbiota. However, it is currently unknown whether the gut microbiota is a key mechanistic target for EA or how EA promotes gut motility
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Similarities and differences between kaiy in Persian medicine and moxibustion in Chinese medicine J. Integr. Med. (IF 4.8) Pub Date : 2023-05-10 Amir Mohammad Jaladat, Mahdi Alizadeh Vaghasloo, Fatemeh Atarzadeh, Mohammad Hossein Ayati, Amir Human Kazemi, Emine Akin, Mohammad Hashem Hashempur
Kaiy (medieval cautery) is an ancient method of heat therapy in traditional Persian medicine (TPM). Some of its important applications have been neglected during the medical revolution. Meanwhile, different treatment modalities that incorporate heat, including moxibustion, have progressed in traditional Chinese medicine. In this study, we reviewed the main TPM textbooks that were written specifically
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A comprehensive overview on the role of phytocompounds in human immunodeficiency virus treatment J. Integr. Med. (IF 4.8) Pub Date : 2023-05-08 Chinmayee Priyadarsani Mandhata, Chita Ranjan Sahoo, Rabindra Nath Padhy
Acquired immune deficiency syndrome (AIDS) is a worldwide epidemic caused by human immunodeficiency virus (HIV) infection. Newer medicines for eliminating the viral reservoir and eradicating the virus are urgently needed. Attempts to locate relatively safe and non-toxic medications from natural resources are ongoing now. Natural-product-based antiviral candidates have been exploited to a limited extent
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Structural characterization, in vivo toxicity and biological activity of two new pyro-type diterpenoid alkaloids derived from 3-acetylaconitine J. Integr. Med. (IF 4.8) Pub Date : 2023-04-07 Yu-jie Wang, Yan Wang, Pei Tao
Objective The transformations that occur in diterpenoid alkaloids during the process of sand frying for Chinese herbal medicine preparation have yet to be clarified. This study investigated the structural changes that take place in 3-acetylaconitine during a simulation of heat-processing and evaluated the toxicity and biological activity of the pyrolysis products. Methods The diterpenoid alkaloid 3-acetylaconitine
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Junctional adhesion molecule-like protein as a novel target for kaempferol to ameliorate lung adenocarcinoma J. Integr. Med. (IF 4.8) Pub Date : 2023-04-06 Qian Wu, Yong-bin Wang, Xiao-wen Che, Hui Wang, Wei Wang
Objective Although there have been improvements in targeted therapy and immunotherapy, the majority of lung adenocarcinoma (LUAD) patients still lack effective therapies. Consequently, it is urgent to screen for new diagnosis biomarkers and pharmacological targets. Junctional adhesion molecule-like protein (JAML) was considered to be an oncogenic protein and may be a novel therapeutic target in LUAD
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Cultural stress: The undiagnosed epidemic of our time J. Integr. Med. (IF 4.8) Pub Date : 2023-03-30 Howard Murad
Global technologies that have made the world more interconnected have also, inadvertently, amplified the forces of stress that are now with us 24 hours a day, 7 days a week. The accumulated impact of this stress I call cultural stress anxiety syndrome and call on integrative medicine practitioners to recognize that it is exacerbating whatever acute stressors are also present in our patients’ lives
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Delivery of acupuncture in clinical trials: Research acupuncturists’ perspectives J. Integr. Med. (IF 4.8) Pub Date : 2023-03-30 Joyce K. Anastasi, Bernadette Capili, Jessica Neumaier, Londa Hackett
Delivery of acupuncture in the setting of a clinical trial is a unique practice that diverges significantly from the delivery of acupuncture in a real-world clinical setting. Research acupuncturists, particularly those trained in traditional Chinese medicine (TCM), are often required to set aside valued precepts of traditional care, including diagnosing imbalances, individualizing treatment, and forging
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Muscle energy technique for chronic obstructive pulmonary disease: A feasibility study J. Integr. Med. (IF 4.8) Pub Date : 2023-03-24 Danielle A. Baxter, Meaghan E. Coyle, Catherine J Hill, Christopher Worsnop, Johannah L. Shergis
Objective This study aimed to investigate the feasibility of implementing a manual therapy technique (muscle energy technique, MET) protocol in a hospital pulmonary rehabilitation (PR) program for patients with moderate to severe chronic obstructive pulmonary disease (COPD). Please cite this article as: Baxter DA, Coyle ME, Hill CJ, Worsnop C, Shergis JL. Muscle energy technique for chronic obstructive
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Mechanical effects of needle texture on acupoint tissue J. Integr. Med. (IF 4.8) Pub Date : 2023-03-23 Ming-zhu Sun, Xin Wang, Ying-chen Li, Wei Yao, Wei Gu
Objective This study aims to clarify how the stimulation of acupuncture points is achieved by needles with different surface texture during acupuncture; it also seeks to lessen injury at the insertion site and increase the therapeutic efficacy of acupuncture, by simulating the mechanical effects of various needle surface patterns on Zusanli (ST36) without changing the radius of acupuncture needles
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Neuroprotective potential of cannabidiol: Molecular mechanisms and clinical implications J. Integr. Med. (IF 4.8) Pub Date : 2023-03-18 Srushti M. Tambe, Suraj Mali, Purnima D. Amin, Mozaniel Oliveira
Cannabidiol (CBD), a nonpsychotropic phytocannabinoid that was once largely disregarded, is currently the subject of significant medicinal study. CBD is found in Cannabis sativa, and has a myriad of neuropharmacological impacts on the central nervous system, including the capacity to reduce neuroinflammation, protein misfolding and oxidative stress. On the other hand, it is well established that CBD