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Phosphoglycerate mutase 5 aggravates alcoholic liver disease through disrupting VDAC-1-dependent mitochondrial integrity Int. J. Med. Sci. (IF 3.6) Pub Date : 2024-2-25 Tian Xia, Jiachi Yu, Ye Chen, Xing Chang, Miao Meng
Alcoholic liver disease (ALD) poses a substantial global health challenge, with its pathogenesis deeply rooted in mitochondrial dysfunction. Our study explores the pivotal roles of Phosphoglycerate mutase family member 5 (Pgam5) and Voltage-Dependent Anion Channel 1 (VDAC1) in the progression of ALD, providing novel insights into their interplay and impact on mitochondrial integrity. We demonstrate
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Proteomics-based Model for Predicting the Risk of Brain Metastasis in Patients with Resected Lung Adenocarcinoma carrying the EGFR Mutation Int. J. Med. Sci. (IF 3.6) Pub Date : 2024-2-25 Qiuhua Deng, Fengnan Wang, Lei Song, Liangyu Chen, Ying Huang, Zhihua Guo, Haihong Yang
Introduction: Epidermal growth factor receptor (EGFR) mutation is common in Chinese patients with lung adenocarcinoma (LUAD). Brain metastases (BMs) is high and associated with poor prognosis. Identification of EGFR-mutant patients at high risk of developing BMs is important to reduce or delay the incidence of BMs. Currently, there is no literature on the prediction and modeling of EGFR brain metastasis
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Impact of Omicron variant infection on the liver, kidney, and coagulation system in patients undergoing elective surgery: a retrospective case-control study Int. J. Med. Sci. (IF 3.6) Pub Date : 2024-2-17 Xiaojuan Xiong, Rui Li, Haoyu Pei, Qingxiang Mao
Purpose: We aimed to investigate the impact of Omicron variant infection on the perioperative organ function in patients undergoing elective surgery./nMethods: A total of 5029 patients who underwent elective surgery between October 2022 and January 2023 at our hospital were enrolled. Among them, the patients who underwent elective surgery between October 2022 and November 2022 composed Group 1 (not
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Hyperoside induces cell cycle arrest and suppresses tumorigenesis in bladder cancer through the interaction of EGFR-Ras and Fas signaling pathways Int. J. Med. Sci. (IF 3.6) Pub Date : 2024-2-12 Kai Yang, Zhi-Xiang Qi, Ming-Xin Sun, Li-Ping Xie
Hyperoside is a natural flavonol glycoside widely found in plants and has been reported to have a variety of pharmacological effects, including anticancer abilities. In this study, we demonstrated for the first time that hyperoside inhibited the proliferation of bladder cancer cells in vitro and in vivo. Moreover, hyperoside could not only induce cell cycle arrest, but also induce apoptosis of a few
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Roxadustat Versus Erythropoietin: The Comparison of Efficacy in Reversing Ventricular Remodeling in Dialysis Patients with Anaemia Int. J. Med. Sci. (IF 3.6) Pub Date : 2024-2-12 Meng Ying Wang, Xiao Qi Liu, Ting Ting Jiang, Wen Tao Liu, Yang Huang, Yu Lin Huang, Feng Yong Jin, Qing Zhao, Qin Yi Wu, Gui Hua Wang, Xiong Zhong Ruan, Kun Ling Ma
Background: Renal anaemia and left ventricular hypertrophy are the main complications of chronic kidney disease and are shared among dialysis patients. This retrospective study aimed to compare the efficacies of the hypoxia-inducible factor prolyl hydroxylase inhibitor roxadustat and recombinant human erythropoietin in reversing ventricular remodeling in dialysis patients with renal anaemia./nMethods:
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The DNA-dependent protein kinase catalytic subunit promotes sepsis-induced cardiac dysfunction through disrupting INF-2-dependent mitochondrial dynamics Int. J. Med. Sci. (IF 3.6) Pub Date : 2024-2-12 Mudi Ma, Hao Zhou, Ying Zhang, Woliang Yuan, Chaoxiong Chen
Sepsis-induced cardiomyopathy (SIC) represents a severe complication of systemic infection, characterized by significant cardiac dysfunction. This study examines the role of DNA-dependent protein kinase catalytic subunit (DNA-PKcs) and Inverted Formin 2 (INF2) in the pathogenesis of SIC, focusing on their impact on mitochondrial homeostasis and dynamics. Our research demonstrates that silencing DNA-PKcs
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A comparative analysis of the doctoral regulations at the medical faculties in Germany Int. J. Med. Sci. (IF 3.6) Pub Date : 2024-2-12 Sarah Altenberger, Roman Leischik, Richard Vollenberg, Jan Peter Ehlers, Markus Strauss
Objective: In order to be allowed to use the title “Dr. med.” in Germany, an independent scientific achievement under the supervision of an established scientist is necessary. The research question, analysis and results are essentially carried out and developed independently by the doctoral student. The doctorate serves as proof that the doctoral candidate is capable of independent academic work. The
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The Protein Acetylation after Traumatic Spinal Cord Injury: Mechanisms and Therapeutic Opportunities Int. J. Med. Sci. (IF 3.6) Pub Date : 2024-2-12 Hong-wei Li, Hai-hong Zhang
Spinal cord injury (SCI) leads to deficits of various normal functions and is difficult to return to a normal state. Histone and non-histone protein acetylation after SCI is well documented and regulates spinal cord plasticity, axonal growth, and sensory axon regeneration. However, our understanding of protein acetylation after SCI is still limited. In this review, we summarize current research on
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METTL3 Promotes Osteogenic Differentiation of Human Periodontal Ligament Stem Cells through IGF2BP1-Mediated Regulation of Runx2 Stability Int. J. Med. Sci. (IF 3.6) Pub Date : 2024-2-4 Xuefei Sun, Xiujiao Meng, Yu Piao, Shaojie Dong, Qianqian Dong
N6-Methyladenosine (m6A) has been reported to play a dynamic role in osteoporosis and bone metabolism. However, whether m6A is involved in the osteogenic differentiation of human periodontal ligament stem cells (hPDLSCs) remains unclear. Here, we found that methyltransferase-like 3 (METTL3) was up-regulated synchronously with m6A during the osteogenic differentiation of hPDLSCs. Functionally, lentivirus-mediated
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Development and validation of a diagnostic nomogram to evaluate tubular atrophy/interstitial fibrosis of IgA nephropathy Int. J. Med. Sci. (IF 3.6) Pub Date : 2024-2-4 Yangang Gan, Yihuan Cai, Jiajia Li, Jianping Wu, Rui Zhang, Qianqian Han, Wenchao Li, Qiongqiong Yang
Background: IgA nephropathy (IgAN) is a cause of chronic kidney disease (CKD). Tubular atrophy/interstitial fibrosis is associated with IgAN prognosis. However, simple tools for predicting pathological lesions of IgAN remain limited. Our objective was to develop a tool for evaluating tubular atrophy/interstitial fibrosis in patients with IgAN./nMethods: In this cross-sectional study, 410 biopsy-verified
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Rosmarinic Acid Protects Skin Keratinocytes from Particulate Matter 2.5-Induced Apoptosis Int. J. Med. Sci. (IF 3.6) Pub Date : 2024-2-4 Herath Mudiyanselage Udari Lakmini Herath, Mei Jing Piao, Kyoung Ah Kang, Pincha Devage Sameera Madushan Fernando, Jin Won Hyun
Background: The exposure of the human skin to particulate matter 2.5 (PM2.5) results in adverse health outcomes, such as skin aging, wrinkle formation, pigment spots, and atopic dermatitis. It has previously been shown that rosmarinic acid (RA) can protect keratinocytes from ultraviolet B radiation by enhancing cellular antioxidant systems and reducing oxidative damage; however, its protective action
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Comparing the Long-Term Cardiovascular Outcomes of Lumbo-Peritoneal, Ventriculo-Peritoneal, or Non-Shunting Treatment after Idiopathic Normal Pressure Hydrocephalus: A Nationwide Retrospective Cohort Study Int. J. Med. Sci. (IF 3.6) Pub Date : 2024-1-27 Cheng-Di Chiu, MD, MBA, PhD, Po-Fan Chiu, MD, Chih-Ying Wu, MD, Hei-Tung Yip, MSc, You-Pen Chiu, MSc, Hui-Ru Ji, MSc, Kai-Cheng Hsu, MD, PhD, Fuu-Jen Tsai, MD, PhD, Robert Chen-Hao Chang, PhD
Purpose: With advances in medical technology, the average lifespan has increased, leading to a growing significance of idiopathic normal pressure hydrocephalus (iNPH), particularly in the elderly population. Most patients with iNPH have been treated either with ventriculo-peritoneal shunts (VPS) or conservative measures. However, lumbo-peritoneal shunts (LPS) have emerged as an alternative treatment
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Comprehensive study on the differential extraction and comparison of bioactive health potential of the Broccoli (Brassica oleracea) Int. J. Med. Sci. (IF 3.6) Pub Date : 2024-1-21 Durga Uvaraj, Naiyf S. Alharbi, Shine Kadaikunnan, Muthu Thiruvengadam, Baskar Venkidasamy
Introduction: Broccoli is a cruciferous vegetable that has been shown to have numerous potential therapeutic benefits because of its bioactive compounds./nMethods: In this study, we compared the bioactive efficacy of cooked and uncooked (fresh) stems and florets of broccoli extracted with three different solvents: acetonitrile, methanol, and aqueous extracts. The extraction yield and antioxidant and
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Enhanced Diagnostic Efficiency of Endometrial Carcinogenesis and Progression in Women with Abnormal Uterine Bleeding through Peripheral Blood Cytokine Testing: A Multicenter Retrospective Cohort Study Int. J. Med. Sci. (IF 3.6) Pub Date : 2024-1-21 Jincheng Ma, Dabin Liu, Xiaodan Mao, Leyi Huang, Yuan Ren, Xiaozhen Xu, Xiaoli Huang, Caiping Deng, Feifeng Shi, Pengming Sun
Objective: This study aimed to evaluate the role of plasma cytokine detection in endometrial cancer screening and tumor progression assessment in patients with abnormal uterine bleeding./nMethods: In this multicenter retrospective cohort study of 287 patients with abnormal uterine bleeding, comprehensive clinical information and laboratory assessments, including cytokines, routine blood tests, and
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Oridonin inhibited epithelial-mesenchymal transition of laryngeal carcinoma by positively regulating LKB1/AMPK signaling Int. J. Med. Sci. (IF 3.6) Pub Date : 2024-1-21 Bo Kou, Yuhan Shi, Zhaoyue Zhou, Yanning Yun, Qun Wu, Jinsong Zhou, Wei Liu
Oridonin is the main bioactive component of Rabdosia rubescens, and its anticancer activity has been reported in a variety of cancers. However, the molecular mechanism of oridonin in laryngeal carcinoma remains unclear. In the present study, the cytotoxic effect of oridonin on laryngeal carcinoma Hep-2 and TU212 cell lines were initially detected by modified MTT assay. The results showed that oridonin
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PKM2 interacts with and phosphorylates PHB2 to sustain mitochondrial quality control against septic cerebral-cardiac injury Int. J. Med. Sci. (IF 3.6) Pub Date : 2024-1-21 Yuanchen Zhao, Yawen Pan, Mengyuan Chen, Ying Tan, Xing Chang, Haixia Li, Yinghao Zhi
Sepsis induces profound disruptions in cellular homeostasis, particularly impacting mitochondrial function in cardiovascular and cerebrovascular systems. This study elucidates the regulatory role of the Pyruvate Kinase M2 (PKM2)- Prohibitin 2 (PHB2) axis in mitochondrial quality control during septic challenges and its protective effects against myocardial and cerebral injuries. Employing LPS-induced
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Effects of Banhabaekchulcheonma-Tang on Brain Injury and Cognitive Function Impairment Caused by Bilateral Common Carotid Artery Stenosis in a Mouse Model Int. J. Med. Sci. (IF 3.6) Pub Date : 2024-1-21 Da-Woon Kim, Jung-Hwa Lim, Suin Cho, Sang-Ho Kim
Vascular dementia (VD) is the second most prevalent dementia type, with no drugs approved for its treatment. Here, the effects of Banhabaekchulcheonma-Tang (BBCT) on ischemic brain injury and cognitive function impairment were investigated in a bilateral carotid artery stenosis (BCAS) mouse model. Mice were divided into sham-operated, BCAS control, L-BBCT (40 ml/kg), and H-BBCT (80 ml/kg) groups. BBCT's
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Ferroptosis: A New Mechanism in Diabetic Cardiomyopathy Int. J. Med. Sci. (IF 3.6) Pub Date : 2024-1-21 Zichong Song, Jingyi Wang, Lijun Zhang
Diabetic cardiomyopathy (DC) is a pathophysiologic condition caused by diabetes mellitus (DM) in the absence of coronary artery disease, valvular heart disease, and hypertension that can lead to heart failure (HF), manifesting itself in the early stages with left ventricular hypertrophy and diastolic dysfunction, with marked HF and decreased systolic function in the later stages. There is still a lack
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The effect of combining prewarming with intraoperative phenylephrine infusion on the prevention of hypothermia in patients undergoing urological surgery: a prospective, randomized, and controlled trial. Int. J. Med. Sci. (IF 3.6) Pub Date : 2023-10-24 Sung-Ae Cho,Seok-Jin Lee,Jun-Ho Kim,Woojin Kwon,Tae-Yun Sung
Background: Hypothermia is common in patients undergoing urological surgery; however, no single preventative modality is completely effective. This study evaluated the effects of combining prewarming with intraoperative phenylephrine infusion for the prevention of hypothermia in patients undergoing urological surgery. Methods: This prospective study enrolled 58 patients scheduled for urological surgery
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Objective Assessment of Perioperative Anxiety using Functional Near-infrared Spectroscopy in Elderly Patients: A Prospective Randomized Observational Pilot Study. Int. J. Med. Sci. (IF 3.6) Pub Date : 2023-10-24 Hyae Jin Kim,Dowon Lee,Hyun-Su Ri,JongKwan Choi,Jinhyung Choi,Seung Joon Rhee,Jiseok Baik,Boo-Young Hwang,Gayoung Park,Jihyun Cha,Sang Don Lee
Background: Assessing and managing patient anxiety is essential to reduce postoperative complications in elderly patients. However, monitoring patient anxiety objectively is impossible. This study aimed to investigate the correlation between the level of fNIRS signals and anxiety in patients aged 65 and older undergoing artificial joint replacement surgery. Material and Methods: Sixty patients aged
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Custom-made Subperiosteal Implants: A Finite Element Analysis on Monoblock and Dual Implant Systems in Atrophic Maxilla. Int. J. Med. Sci. (IF 3.6) Pub Date : 2023-10-16 Mustafa Ayhan,Abdulkadir Burak Cankaya
This study aims to investigate and compare the stress distribution, displacement, and bone loading of monoblock and dual custom-made subperiosteal implant systems in atrophic maxilla using finite element analysis (FEA). A total of 11 patients with insufficient bone tissue for conventional implant treatment were included in the study. Customized subperiosteal implant designs were generated using the
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TMED family genes and their roles in human diseases. Int. J. Med. Sci. (IF 3.6) Pub Date : 2023-10-16 Lv Zhou,Huaixu Li,Hui Yao,Xingliang Dai,Peng Gao,Hongwei Cheng
The members of the transmembrane emp24 domain-containing protein (TMED) family are summarized in human as four subfamilies, α (TMED 4, 9), β (TMED 2), γ (TMED1, 3, 5, 6, 7) and δ (TMED 10), with a total of nine members, which are important regulators of intracellular protein transport and are involved in normal embryonic development, as well as in the pathogenic processes of many human diseases. Here
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Extracellular Vesicles in Sepsis: Pathogenic Roles, Organ Damage, and Therapeutic Implications. Int. J. Med. Sci. (IF 3.6) Pub Date : 2023-10-16 Ni An,Zhe Chen,Peng Zhao,Wen Yin
Despite significant advances in anti-infective treatment and organ function support technology in recent years, the mortality rate of sepsis remains high. In addition to the high costs of sepsis treatment, the increasing consumption of medical resources also aggravates economic pressure and social burden. Extracellular vesicles (EVs) are membrane vesicles released from different types of activated
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Increased Expression of Tetraspanins, ALIX and HSP-70 in the Placenta Tissue of Women with Chronic Venous Disease during Pregnancy. Int. J. Med. Sci. (IF 3.6) Pub Date : 2023-10-16 Miguel A Ortega,María Asunción Sánchez-Gil,Oscar Fraile-Martínez,Cielo García-Montero,Luis G Guijarro,Raúl Diaz-Pedrero,Laura Lopez-Gonzalez,Juan De Leon-Luis,Coral Bravo,Melchor Álvarez-Mon,Julia Bujan,Miguel A Saez,Natalio García-Honduvilla
Chronic venous disease (CVD) is a complex and common vascular disorder characterized by increased blood pressure and morpho-functional changes in the venous system like varicose veins. Pregnancy is one of the main risk factors for suffering from this condition. Despite the consequences of CVD during pregnancy remains to be fully understood, compelling evidence support that this condition represents
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Utilization of sodium-glucose cotransporter 2 inhibitors on dry eye disease severity in patients with type 2 diabetes mellitus. Int. J. Med. Sci. (IF 3.6) Pub Date : 2023-10-09 Yen-Po Yao,Po-Jen Yang,Chia-Yi Lee,Jing-Yang Huang,Shun-Fa Yang,Hung-Yu Lin
Sodium-glucose cotransporter 2 (SGLT2) inhibitors have protective effects against various systemic diseases and neoplasms. This retrospective cohort study evaluated the severity of dry eye disease (DED) in patients with type 2 diabetes mellitus (T2DM) who were treated with SGLT2 inhibitors. Data were obtained from the National Health Insurance Research Database of Taiwan. Patients with T2DM who were
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Use of metagenomic next-generation sequencing for diagnosis of peritonitis in end-stage liver disease. Int. J. Med. Sci. (IF 3.6) Pub Date : 2023-10-09 Taiyu He,Ning Luo,Juan Kang,Ning Ling,Dazhi Zhang
Background: Conventional methods are low in positive rates and time-consuming for ascites pathogen detection in patients with end-stage liver disease (ESLD). With many advantages, metagenomic next-generation sequencing (mNGS) may be a good alternative method. However, the related studies are still lacking. Methods: Ascites from 50 ESLD patients were sampled for pathogen detection using mNGS and conventional
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The effects of E'Jiao on body composition, bone marrow adiposity and skeletal redox status in ovariectomised rats. Int. J. Med. Sci. (IF 3.6) Pub Date : 2023-10-09 Sophia Ogechi Ekeuku,Kok-Yong Chin,Jing Qian,Yan Zhang,Haibin Qu,Fairus Ahmad,Sok Kuan Wong,Mohd Mustazil Mohd Noor,Ima Nirwana Soelaiman
Background: Menopause is accompanied by increased oxidative stress, partly contributing to weight gain and bone marrow adiposity. Traditional Chinese medication, E'Jiao, has been demonstrated to reduce excessive bone remodelling during oestrogen deprivation, but its effects on body composition and bone marrow adiposity during menopause remain elusive. Objective: To determine the effects of E'Jiao on
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Strontium Ranelate Ameliorates Intervertebral Disc Degeneration via Regulating TGF-β1/NF-κB Axis. Int. J. Med. Sci. (IF 3.6) Pub Date : 2023-10-07 Ruping Sun,Jian Zhu,Kaiqiang Sun,Lu Gao,Bing Zheng,Jiangang Shi
Intervertebral disc degeneration (IVDD) is a prevalent and debilitating condition characterized by chronic back pain and reduced quality of life. Strontium ranelate (SRR) is a compound traditionally used for treating osteoporosis via activating TGF-β1 signaling pathway. Recent studies have proved the anti-inflammatory effect of SRR on chondrocytes. Although the exact mechanism of IVDD remains unclear
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The Structural Proteins of Membrane Rafts, Caveolins and Flotillins, in Lung Cancer: More Than Just Scaffold Elements. Int. J. Med. Sci. (IF 3.6) Pub Date : 2023-10-02 Ana Karina Saldaña-Villa,Roberto Lara-Lemus
Lung cancer is one of the most frequently diagnosed cancers worldwide. Due to its late diagnosis, it remains the leading cause of cancer-related deaths. Despite it is mostly associated to tobacco smoking, recent data suggested that genetic factors are of the highest importance. In this context, different processes meaningful for the development and progression of lung cancer such endocytosis, protein
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Efficacy of levocetirizine in isolated rat tracheal smooth muscle. Int. J. Med. Sci. (IF 3.6) Pub Date : 2023-10-02 Ying-Liang Chou,Yueh-Ting Wang,Li-Hsiang Cheng,Shao-Cheng Liu,Hsing-Won Wang
Histamine receptor-1 (H1) antagonists like levocetirizine are frequently used nowadays to treat rhinitis patients who experience rhinorrhea and sneezing. The trachea may be affected by the H1 antagonist when it is used to treat nasal symptoms, either orally or through inhalation. The purpose of this study was to ascertain in vitro effects of levocetirizine on isolated tracheal smooth muscle. As a parasympathetic
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Preclinical models for Type 1 Diabetes Mellitus - A practical approach for research. Int. J. Med. Sci. (IF 3.6) Pub Date : 2023-10-02 Xi Peng,Guocheng Rao,Xinqiong Li,Nanwei Tong,Yan Tian,Xianghui Fu
Numerous preclinical models have been developed to advance biomedical research in type 1 diabetes mellitus (T1DM). They are essential for improving our knowledge of T1DM development and progression, allowing researchers to identify potential therapeutic targets and evaluate the effectiveness of new medications. A deeper comprehension of these models themselves is critical not only to determine the
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Tumor necrosis factor-alpha mediates the negative association between telomere length and kidney dysfunction. Int. J. Med. Sci. (IF 3.6) Pub Date : 2023-09-25 Mengya Qi,Jie Yu,Fan Ping,Lingling Xu,Wei Li,Huabing Zhang,Yuxiu Li
Aim/hypothesis: The relationship between peripheral blood leukocyte telomere length (LTL) and kidney dysfunction, especially in people with hypertension, remains unclear. No clinical study has explored the role of inflammation and oxidative stress in the relationship between LTL and kidney dysfunction. Therefore, we examined the relationship between baseline LTL and albuminuria progression and/or rapid
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Uric acid-based ratios for predicting renal failure in Chinese IgA nephropathy patients. Int. J. Med. Sci. (IF 3.6) Pub Date : 2023-09-25 Aiya Qin,Dandan Yang,Siqing Wang,Lingqiu Dong,Jiaxing Tan,Yi Tang,Wei Qin
Objective: The uric acid/albumin ratio (UAR), a novel, simple, and compositive laboratory biomarker, has recently attracted attention for predicting disease prediction and disease prognosis. However, whether uric acid-related biomarkers (especially UAR) could serve as prognostic indicator for IgAN is unclear. Methods: In this retrospective cohort study, biopsy-confirmed IgAN patients from 2009 to 2017
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Identification of lncRNAs associated with uterine corpus endometrial cancer prognosis based on the competing endogenous RNA network. Int. J. Med. Sci. (IF 3.6) Pub Date : 2023-09-25 Liangxiao Wang,Xianwei Su,Liangyu Wang,Jianbo Luo,Zhiqiang Xiong,Geoffrey Ho Duen Leung,Jingye Zhou,Guang Yang,Li Zhai,Xi Zhang,Qiang Liu,Gang Lu,Yuming Wang
Uterine Corpus Endometrial Carcinoma (UCEC) is one of the major malignant tumors of the female reproductive system. However, there are limitations in the currently available diagnostic approaches for UCEC. Long non-coding RNAs (lncRNAs) play important roles in regulating biological processes as competitive endogenous RNA (ceRNA) in tumors. To study the potential of lncRNAs as non-invasive diagnostic
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GAS1 Promotes Ferroptosis of Liver Cells in Acetaminophen-Induced Acute Liver Failure. Int. J. Med. Sci. (IF 3.6) Pub Date : 2023-09-25 Jinqiu Tao,Cailin Xue,Xiaodong Wang,Huihui Chen,Qiaoyu Liu,Chunping Jiang,Wenjie Zhang
Purpose: Acute liver failure (ALF) is a clinically fatal disease that leads to the rapid loss of normal liver function. Acetaminophen (APAP) is a leading cause of drug-induced ALF. Ferroptosis, defined as iron-dependent cell death associated with lipid peroxide accumulation, has been shown to be strongly associated with APAP-induced liver injury. Growth arrest-specific 1 (GAS1) is a growth arrest-specific
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DKK1 Ameliorates Myofibroblast Differentiation in Urethral Fibrosis in Vivo and in Vitro by Regulating the Canonical Wnt Pathway. Int. J. Med. Sci. (IF 3.6) Pub Date : 2023-09-25 Shanlong Huang,Delai Fu,Ziyan Wan,Zhixin Huang,Min Li,Hecheng Li,Tie Chong
Background: Urethral stricture is a common disorder of the lower urinary tract in men. A complex network of pathways and interactions are involved in the pathogenesis of urethral fibrosis. However, the mechanisms underlying urethral fibrosis remain poorly understood. Objectives: To investigate the critical role of the canonical Wnt pathway in development of urethral fibrosis and explore DKK1, the endogenous
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Artesunate induces ferroptosis by inhibiting the nuclear localization of SREBP2 in myeloma cells. Int. J. Med. Sci. (IF 3.6) Pub Date : 2023-09-18 Laoqi Liang,Yang Liu,Xiaoyan Wu,Yan Chen
Objective: Multiple myeloma (MM) is an incurable haematological cancer characterized by abnormal proliferation of plasma cells. The promising therapeutic effect of selective inhibitors of nuclear export in MM reveals the broad therapeutic prospects of nuclear localization intervention. Sterol regulatory element binding protein 2 (SREBP2) is a lipid regulatory molecule that has been implicated in the
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Intermittent Hypoxia Conditioning: A Potential Multi-Organ Protective Therapeutic Strategy. Int. J. Med. Sci. (IF 3.6) Pub Date : 2023-09-18 Qihan Zhang,Wenbo Zhao,Sijie Li,Yuchuan Ding,Yuan Wang,Xunming Ji
Severe hypoxia can induce a range of systemic disorders; however, surprising resilience can be obtained through sublethal adaptation to hypoxia, a process termed as hypoxic conditioning. A particular form of this strategy, known as intermittent hypoxia conditioning hormesis, alternates exposure to hypoxic and normoxic conditions, facilitating adaptation to reduced oxygen availability. This technique
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Critical Overview on Pure Chitosan-based Scaffolds for Bone Tissue Engineering: Clinical insights in Dentistry. Int. J. Med. Sci. (IF 3.6) Pub Date : 2023-09-18 Luca Signorini,Gaetano Marenzi,Anastasia Facente,Benedetta Marrelli,Rosa Maria Marano,Alessandra Valletta,Luciano Pacifici,Roberta Gasparro,Gilberto Sammartino,Marco Severino
Bone Tissue Engineering (BTE) is a field of regenerative medicine continuously improving, thanks to the development of new biomaterials used as grafts or scaffolds for repairing bone defects. In recent years, chitosan, a natural biopolymer extracted mainly from crustacean shells, has demonstrated unique and desirable characteristics for BTE applications, such as: biocompatibility, biodegradability
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High-dose remifentanil exacerbates myocardial ischemia-reperfusion injury through activation of calcium-sensing receptor-mediated pyroptosis. Int. J. Med. Sci. (IF 3.6) Pub Date : 2023-09-18 Yejing Zhu,Jinyu Chi,Shunv Cai,Siqi Liu,Junbo Yuan,Hongliang Xu,Huidan Zhou
Background: The aim of this study was to investigate whether calcium-sensing receptor (CaSR) was involved in HRF-mediated exacerbation of MI/R injury through NLRP3 inflammasome activation and pyroptosis. Methods: In vivo, a rat MI/R model was established by ligating the left coronary artery, and short-term HRF exposure was induced during reoxygenation. Then, TUNEL, H&E, Masson staining, immunohistochemical
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Decreased miR-329-3p upregulates Adamts4 and Dnajb1 in mouse hepatic I/R injury in an age-independent manner. Int. J. Med. Sci. (IF 3.6) Pub Date : 2023-09-18 Lin Zhu,Wu Duan,Bo Yang,Lan Wang
Introduction: Hepatic ischemia/reperfusion (I/R) injury is common after liver surgery, particularly in patients of older age. However, an understanding of the mechanism of injury remains incomplete. In this study, we explored the molecular mechanisms underlying hepatic I/R injury and associations with age in a murine model. Methods: Gene expression profiling datasets (GSE72315 and GSE10654) and a microRNA
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Effects of maternal toxic substance consumption during breastfeeding on lactic acid bacteria abundance and nutritional content. Int. J. Med. Sci. (IF 3.6) Pub Date : 2023-09-11 Jesús Alonso Amezcua López,Elisa García Morales,Daniel Pérez-Rulfo Ibarra,Josué Raymundo Solís Pacheco,Blanca Rosa Aguilar Uscanga
Breast milk is widely recognized as the primary source of nourishment for newborns, making it an unparalleled and indispensable provider of essential nutrients, microbiological components, immunological factors, and energy content. To investigate this further, a cohort comprising 254 breastfeeding women participated in interviews, and milk samples were aseptically collected for subsequent analysis
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Research Progress of Exosomal Non-Coding RNAs in Cardiac Remodeling. Int. J. Med. Sci. (IF 3.6) Pub Date : 2023-09-11 Yang Liu,Xing Lyu,Shengyu Tan,Xiangyu Zhang
Exosomes are vesicles with a size range of 50 to 200 nm and released by different cells, which are essential for the exchange of information between cells. They have attracted a lot of interest from medical researchers. Exosomal non-coding RNAs play an important part in pathological cardiac remodelings, such as cardiomyocyte hypertrophy, cardiomyocyte apoptosis, and cardiac fibrosis. This review summarizes
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STARD12/14 are diagnostic and prognostic biomarkers of lung adenocarcinoma associated with epigenetic regulation, immune infiltration and ferroptosis. Int. J. Med. Sci. (IF 3.6) Pub Date : 2023-09-11 Wen-Di Zhang,Dong-Mei Hu,Zhuang-E Shi,Qing-Xiang Wang,Meng-Yu Zhang,Jian-Yu Liu,Xiu-Li Ji,Yi-Qing Qu
Background: Metabolic reprogramming plays an important role in tumor progression and antitumor immunity. START domain-containing proteins (STARDs) are responsible for lipid metabolism. However, the underlying functions of STARDs in lung adenocarcinoma (LUAD) have not been clarified yet. Methods: Oncomine, UALCAN, TCGA and CPTAC were used to explore the expression landscape and clinicopathological characteristics
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The obesity paradox in Japanese COVID-19 patients. Int. J. Med. Sci. (IF 3.6) Pub Date : 2023-09-11 Junichi Yoshida,Kaoru Setoguchi,Kenichiro Shiraishi,Tetsuya Kikuchi,Masao Tanaka
Purpose: To investigate the effect of obesity on mortality and invasive respiratory care (IRC) in patients with COVID-19. Methods: We studied 1,105 patients for 34 months and collected data. The primary outcome was all-cause death at 29 days. The secondary outcome was IRC indicated by a pulse oximetry rate below 93% at a mask oxygenation rate of 5 L/min or more. Results: Age- and sex-adjusted multivariate
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The Protective Effects of Eicosapentaenoic Acid for Stress-induced Accelerated Senescence in Vascular Endothelial Cells. Int. J. Med. Sci. (IF 3.6) Pub Date : 2023-09-11 Min Jeong Kwon,Hye Sook Jung,Seon Mee Kang,Soon Hee Lee,Jeong Hyun Park
Background: Eicosapentaenoic acid (EPA) is an omega-3 fatty acid that protects against cardiovascular diseases in patients with hypertriglyceridemia and may have pleotropic effects beyond lowering triglycerides. Many degenerative diseases, such as atherosclerosis and diabetes, are related to cellular senescence as a pathophysiological mechanism. We aimed to examine whether EPA could protect vascular
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Human umbilical cord mesenchymal stem cells in diabetes mellitus and its complications: applications and research advances. Int. J. Med. Sci. (IF 3.6) Pub Date : 2023-09-11 Luyao Li,Jicui Li,Haifei Guan,Hisashi Oishi,Satoru Takahashi,Chuan Zhang
Diabetes mellitus and its complications pose a major threat to global health and affect the quality of life and life expectancy of patients. Currently, the application of traditional therapeutic drugs for diabetes mellitus has great limitations and can only temporarily control blood glucose but not fundamentally cure it. Mesenchymal stem cells, as pluripotent stromal cells, have multidirectional differentiation
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Tight Junction Protein 1 Suppresses Kidney Renal Clear Cell Carcinoma Cells Proliferation by Inducing Autophagy. Int. J. Med. Sci. (IF 3.6) Pub Date : 2023-09-11 Miao Li,Di-Sheng Zhou,Xin-Rong Shao,Sze-Hoi Chan,Zhao-Xia Dong,Xue-Qi Liu,Shu-Na Chen,Lin Qi,Luis Velasquez Zarate,Xiao-Mei Wang,Xin Du,Xing-Ding Zhang
TJP1, an adaptor protein of the adhesive barrier, has been found to exhibit distinct oncogenic or tumor suppressor functions in a cell-type dependent manner. However, the role of TJP1 in kidney renal clear cell carcinoma (KIRC) remains to be explored. The results showed a marked down-regulation of TJP1 in KIRC tissues compared to normal tissues. Low expression of TJP1 was significantly associated with
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Dasatinib regulates the proliferation and osteogenic differentiation of PDLSCs through Erk and EID3 signals. Int. J. Med. Sci. (IF 3.6) Pub Date : 2023-09-11 Linglu Jia,Yafei Zhang,Shaoqing Sun,Xingyao Hao,Yong Wen
Periodontal ligament stem cells (PDLSCs) are important candidate seed cells for alveolar bone tissue engineering. Dasatinib is a tyrosine kinase inhibitor, and its influence on the osteogenic differentiation of mesenchymal stem cells is a controversial topic. The present study explored the effects of different concentrations of dasatinib on the proliferation and osteogenic differentiation of PDLSCs
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U-shaped association between triglyceride and risk of incident diabetes in normoglycemic males with NAFLD: A population-base cohort study. Int. J. Med. Sci. (IF 3.6) Pub Date : 2023-09-04 Xuemei Xie,Jixiang Liao,Chenghu Huang,Xiaowei Li,Qiuli Cao,Lijuan Kong,Takuro Okamura,Yoshitaka Hashimoto,Akihiro Obora,Takao Kojima,Michiaki Fukui,Masahide Hamaguchi,Zuojie Luo,Yingfen Qin,Xinghuan Liang,Xiuping Xuan
Background: Serum triglyceride (TG) was an important biomarker for nonalcoholic fatty liver disease (NAFLD), and the association between TG and incident type 2 diabetes mellitus is still under debate with some studies suggesting that elevated TG increase the risk of incident T2DM while others indicative of a negative relationship. These controversial findings may be partially due to the inclusion of
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Prognostic value and immunological roles of GPX3 in gastric cancer. Int. J. Med. Sci. (IF 3.6) Pub Date : 2023-09-04 Qijin He,Na Chen,Xu Wang,Ping Li,Limin Liu,Zheng Rong,Wentian Liu,Kui Jiang,Jingwen Zhao
Objective: The prognosis for gastric cancer (GC), a prevalent tumor of the digestive system, is unfavorable. The involvement of glutathione peroxidase 3 (GPX3) in tumorigenesis is significant, yet its specific role in GC remains insufficiently investigated. Thus, the aim of this study was to determine the potential impact of GPX3 on GC and elucidate the underlying mechanism. Methods: The expression
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Pen Yan Jing Tablets Alleviates Pelvic Inflammatory Disease by Inhibiting Akt/NF-κB Pathway. Int. J. Med. Sci. (IF 3.6) Pub Date : 2023-09-04 Ping Tang,Qi Ding,Juan Lin,Xinrong Yang,Yiting Wang,Fangle Liu,Yuying Zheng,Liuqing Lin,Deqin Wang,Baoqin Lin
Purpose: Pen Yan Jing tablets (PYJ), a Chinese patent medicine, has being used for pelvic inflammatory disease (PID) effectively. This study was designed to explore the underlying mechanisms of PYJ for treating PID. Methods: A rat model of PID was established by mixed bacteria liquid plus mechanical damage. After PYJ treatment, the morphology of uteri and extent of pelvic adhesion were observed. The
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22q11.2 Deletion Syndrome in Taiwan: Clinical Presentation and Immune System Status of Patients. Int. J. Med. Sci. (IF 3.6) Pub Date : 2023-09-04 Chung-Lin Lee,Shan-Miao Lin,Ming-Ren Chen,Chih-Kuang Chuang,Huei-Ching Chiu,Yuan-Rong Tu,Yun-Ting Lo,Ya-Hui Chang,Hsiang-Yu Lin,Shuan-Pei Lin
Background: 22q11.2 deletion syndrome (22q11.2DS) is a microdeletion syndrome exhibiting significant clinical phenotype variability. This study aimed to investigate the clinical features, immune profiles, and cognitive abilities of 22q11.2DS patients receiving treatment at MacKay Memorial Hospital in Taipei, Taiwan. Methods: This is a cross-sectional analysis between January 2001 and December 2022
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Repeated Low-Level Red-Light Therapy for Controlling Onset and Progression of Myopia-a Review. Int. J. Med. Sci. (IF 3.6) Pub Date : 2023-09-04 Qin Zhu,Xuejun Cao,Yuan Zhang,Yuan Zhou,Jieying Zhang,Xiaofan Zhang,Yingting Zhu,Liping Xue
Repeated low-level red-light (RLRL), characterized by increased energy supply and cellular metabolism, thus enhancing metabolic repair processes, has gained persistent worldwide attention in recent years as a new novel scientific approach for therapeutic application in myopia. This therapeutic revolution led by RLRL therapy is due to significant advances in bioenergetics and photobiology, for instance
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Hypoxia-induced long non-coding RNA LINC00460 promotes p53 mediated proliferation and metastasis of pancreatic cancer by regulating the miR-4689/UBE2V1 axis and sequestering USP10. Int. J. Med. Sci. (IF 3.6) Pub Date : 2023-09-04 Ronghao Zhang,Xinjing Wang,Xiayang Ying,Yishu Huang,Shuyu Zhai,Minmin Shi,Xiaomei Tang,Jia Liu,Yusheng Shi,Fanlu Li,Weishen Wang,Xiaxing Deng
Long non-coding RNAs are considered to be key regulatory factors of oncogenesis and tumor progression. It is reported that LINC00460 plays the role of oncogene in some tumors. However, LINC00460's role and mechanism of action in pancreatic cancer have not yet been fully elucidated. We identified LINC00460 by analyzing data from the Gene Expression Omnibus database. The role of LINC00460 in proliferation
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Adverse Events of Everolimus in Patients with Tuberous Sclerosis Complex Treated for Renal Angiomyolipoma/Subependymal Giant Cell Astrocytoma. Int. J. Med. Sci. (IF 3.6) Pub Date : 2023-09-04 Shuo-Yan Gau,Sung-Lang Chen,Cheng-Siu Chang,Teng-Fu Tsao,Jeng-Dau Tsai
Background: Although regarded as a potentially efficient approach to address tuberous sclerosis complex (TSC)-associated complications, the adverse event profile of everolimus has not yet been fully elucidated. The present study aimed to clarify the adverse event spectrum in patients with TSC who are using everolimus for common indications, in comparison to those who do not use everolimus. Materials
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Microvesicles and inflammatory markers in an animal model of chronic postcapillary pulmonary hypertension. Int. J. Med. Sci. (IF 3.6) Pub Date : 2023-08-28 Elva Maria Mendoza Zambrano,Belén Gómez Rodríguez,Inés García Lunar,Daniel Pereda Arnau,Verónica Sánchez-López,Ana García Álvarez,Remedios Otero Candelera
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Clinical association and diagnostic significance of miRNA-29a and miRNA-147b in type 2 diabetes mellitus. Int. J. Med. Sci. (IF 3.6) Pub Date : 2023-08-28 Phan The Dzung,Ngo Tat Trung,Le Van Khanh,Duong Dinh Chinh,Doan Van De,Hoang Van Tong,Nguyen Linh Toan
Background: Micro RNAs (miRs) expression is involved in the pathogenesis of type 2 diabetes mellitus (T2DM). This study investigates the expression levels of plasma miR-29a, miR-146a, and miR-147b and their correlations with clinical parameters in patients with T2DM. Methods: 105 patients with T2DM who categorized either as newly diagnosed T2DM (n=52) or treated T2DM (n=53) and 93 healthy individuals
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Electric field promotes dermal fibroblast transdifferentiation through activation of RhoA/ROCK1 pathway. Int. J. Med. Sci. (IF 3.6) Pub Date : 2023-08-28 Wenping Wang,Wanqi Huang,Jie Liu,Ze Zhang,Ran Ji,Chao Wu,Jiaping Zhang,Xupin Jiang
With the increased incidence of age-related and lifestyle-related diseases, chronic wounds are sweeping the world, where recent studies reveal that dysfunction of fibroblast plays an indispensable role. Endogenous electric field (EF) generated by skin wound disrupting an epithelial layer has been used as an alternative clinical treatment in chronic wound by modulating cellular behaviours, including
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Comprehensive Analysis of Sideroflexin 4 in Hepatocellular Carcinoma by Bioinformatics and Experiments. Int. J. Med. Sci. (IF 3.6) Pub Date : 2023-08-21 Zhipeng Du,Zhongchao Zhang,Xu Han,Huaping Xie,Wei Yan,Dean Tian,Mei Liu,Caijun Rao
Background: Sideroflexins (SFXNs) are a family of highly conserved mitochondrial transporters which regulate iron homeostasis and mitochondrial respiratory chain. However, the roles and mechanisms of SFXNs in HCC remain unknown. Methods: SFXNs expression and prognostic value in HCC was comprehensively analyzed. Proteins interacting with SFXN4 were analyzed in STRING database. The co-expression genes