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The Effect of Thyroid Surgery on the Accuracy of Palpation-Based Cricothyroid Membrane Identification in Female Patients: A Prospective Observational Cohort Study Medicina (IF 2.948) Pub Date : 2024-03-13 Jaesik Park, A Rim Yang, Hyunji Lee, Kwangsoon Kim, Min Suk Chae
Background and Objectives: This study examined how a history of thyroid surgery impacts the precision of cricothyroid membrane (CTM) identification through palpation (validated by ultrasound) in female patients visiting the operating room for surgeries unrelated to neck procedures. Materials and Methods: This prospective observational cohort study enrolled adult female patients undergoing elective
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The Role of Continuous Glucose Monitoring in Detecting Early Dysglycemia and Clinical Outcomes in Patients with Cystic Fibrosis Medicina (IF 2.948) Pub Date : 2024-03-14 Lora Stanka Kirigin Biloš, Velimir Altabas, Andrea Vukić Dugac, Maja Baretić
Cystic fibrosis-related diabetes (CFRD) is the most common comorbidity in patients with cystic fibrosis (CF). CFRD has been correlated with important clinical outcomes, including poor nutrition, reduced pulmonary function, and earlier mortality. However, clinical decline due to abnormalities of blood glucose (dysglycemia) begins early in CF, before the diagnosis of CFRD by the gold-standard oral glucose
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Primary Thyroid Lymphoma: A Retrospective-Observational Study in a Single Institutional Center Medicina (IF 2.948) Pub Date : 2024-03-14 Octavia Vita, Alis Dema, Robert Barna, Remus Cornea, Dan Brebu, Mihaela Vlad, Oana Popa, Ioana Muntean, Diana Szilagyi, Mihaela Iacob, Maria Iordache, Marioara Cornianu, Dorela Codruta Lazureanu
Background and Objectives: primary thyroid lymphoma (PTL) is a rare neoplasm, displaying a variety of histological features. It is often a challenge for pathologists to diagnose this tumor. Materials and Methods: this study is a retrospective analysis of clinical and pathological characteristics of a group of eleven patients (eight women and three men, mean age 68 years, range 50–80 years) diagnosed
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Relationship between XPA, XPB/ERCC3, XPF/ERCC4, and XPG/ERCC5 Polymorphisms and the Susceptibility to Head and Neck Carcinoma: A Systematic Review, Meta-Analysis, and Trial Sequential Analysis Medicina (IF 2.948) Pub Date : 2024-03-14 Mohammad Moslem Imani, Masoumeh Basamtabar, Sattar Akbari, Edris Sadeghi, Masoud Sadeghi
Background and Objectives: Nucleotide Excision Repair (NER), the most extensively researched DNA repair mechanism, is responsible for repairing a variety of DNA damages, and Xeroderma Pigmentosum (XP) genes participate in NER. Herein, we aimed to update the previous results with a meta-analysis evaluating the association of XPA, XPB/ERCC3, XPF/ERCC4, and XPG/ERCC5 polymorphisms with the susceptibility
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PD-L1 Expression and Tumour Microenvironment Patterns in Resected Non-Small-Cell Lung Cancer Medicina (IF 2.948) Pub Date : 2024-03-14 Giedrė Gurevičienė, Jurgita Matulionė, Lina Poškienė, Skaidrius Miliauskas, Marius Žemaitis
Background and Objectives: Although perioperative immunotherapy is implemented as a standard of care for resected non-small cell lung cancer (NSCLC), there is unmet need for predictive biomarkers as programmed death-ligand 1 (PD-L1) is not the perfect one. The functionality of tumour-infiltrating immune cells in the tumour microenvironment (TME) and the involvement in immune system response is one
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Arthroscopic Medialization Partial Repair with Biologic Interposition Tuberoplasty for Large to Massive Irreparable Rotator Cuff Tear Medicina (IF 2.948) Pub Date : 2024-03-14 Jae-Wook Jung, Joong-Bae Seo, Jun-Yeul Lee, Jae-Sung Yoo
An irreparable rotator cuff tear is a challenging condition to treat, and various treatment modalities are being introduced. Medialization in the partial repair method has the limitation of exposing the tuberosity, while tension-free biologic interposition tuberoplasty using acellular dermal matrix has the limitation of exposing the humeral head. The authors believe that by combining these two techniques
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MicroRNA Expression in Endometrial Cancer: Current Knowledge and Therapeutic Implications Medicina (IF 2.948) Pub Date : 2024-03-15 Irene Iavarone, Rossella Molitierno, Pietro Fumiento, Maria Giovanna Vastarella, Stefania Napolitano, Maria Teresa Vietri, Pasquale De Franciscis, Carlo Ronsini
Background and Objectives: An extracellular vesicle is part of a class of submicron particles derived from cells, mediating cellular crosstalk through microRNA (miRNA). MiRNA is a group of RNA molecules, each of which consists of 15–22 nucleotides and post-transcriptionally modulates gene expression. The complementary mRNAs—onto which the miRNAs hybridize—are involved in processes such as implantation
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Dilatation and Curettage after Uterine Artery Embolization versus Methotrexate Injection for the Treatment of Cesarean Scar Pregnancy: A Single-Center Experience Medicina (IF 2.948) Pub Date : 2024-03-15 Basilio Pecorino, Giuseppe Scibilia, Bianca Mignosa, Maria Cristina Teodoro, Benito Chiofalo, Paolo Scollo
Background and Objectives: Cesarean scar pregnancy (CSP) represents a type of ectopic pregnancy in which the embryo implants inside the scar of a previous cesarean section. This condition can lead to maternal morbidity and mortality. The best therapeutic approach in terms of clinical effectiveness and patient safety for CSP has not been described yet, although different therapeutic strategies are currently
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Social Inhibition and Depressive Symptoms among Couples with Children with Autism Spectrum Disorder: The Mediating Role of Perceived Family Support Medicina (IF 2.948) Pub Date : 2024-03-15 Ting Pan, Tinakon Wongpakaran, Nahathai Wongpakaran, Bijing He, Danny Wedding
Background and Objectives: A limited understanding exists regarding the intricate dynamics between the levels of social inhibition exhibited by both wives and husbands concerning their perceived family support and depressive symptoms, particularly within couples who are parents of children diagnosed with autism spectrum disorder (ASD). Materials and Methods: This study used the actor–partner interdependence
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Polyurethane Microstructures for 2′-Deoxycytidinic Acid Delivery: Preparation and Preliminary Characterization Medicina (IF 2.948) Pub Date : 2024-03-16 Roxana Maria Jeleriu, Bogdana Cavaloiu, Lidia Manuela Onofrei, Florin Borcan, Ramona Carmen Albulescu, Maria Puiu
Background and Objectives: Nucleotide delivery has emerged as a noteworthy research trend in recent years because of its potential utility in addressing a range of genetic defects resulting in the presence of incorrect nucleotides. The primary goals of this research were to create and to characterize polyurethane microstructures, with the aim of utilizing them for nucleotide transport. Materials and
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Respiratory Support Effects over Time on Regional Lung Ventilation Assessed by Electrical Impedance Tomography in Premature Infants Medicina (IF 2.948) Pub Date : 2024-03-17 Ernestas Virsilas, Arunas Valiulis, Raimondas Kubilius, Skaiste Peciuliene, Arunas Liubsys
Background and objectives: Respiratory distress syndrome (RDS) frequently necessitates respiratory support. While non-invasive methods are typically the preferred approach, mechanical ventilation becomes necessary for patients with insufficient response. Our study aimed to compare two common respiratory support modes, volume-targeted mechanical ventilation and non-invasive ventilation continuous positive
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Overview of Cochrane Systematic Reviews for Rehabilitation Interventions in Individuals with Upper Limb Fractures: A Mapping Synthesis Medicina (IF 2.948) Pub Date : 2024-03-12 Sara Liguori, Antimo Moretti, Giuseppe Toro, Chiara Arienti, Michele Patrini, Carlotte Kiekens, Stefano Negrini, Giovanni Iolascon, Francesca Gimigliano
Background and Objectives. This overview of Cochrane systematic reviews (CSRs) reports on current evidence on the effectiveness of rehabilitation interventions for persons with upper limb fractures (ULFs), and the quality of the evidence. Materials and Methods. Following the inclusion criteria defined by the World Health Organization, all CSRs tagged in the Cochrane Rehabilitation database that were
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Minimally Invasive Management and Diagnosis of Ectopic Splenic Pregnancy Medicina (IF 2.948) Pub Date : 2024-03-13 Vestina Strakšytė, Rūta Mikšytė, Ugnė Kulnickaitė, Simas Gudelevičius
This report describes the case of a 32-year-old woman with ectopic pregnancy in the spleen, which was complicated by active bleeding. The patient complained of intermittent pain in her left side and lower abdomen that lasted several days. The serum beta-human chorionic gonadotropin (β-hCG) was increased, but no intrauterine gestational sac was found via transvaginal sonography. A computed tomography
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Exposure to Environmental Pesticides and the Risk of Autism Spectrum Disorders: A Population-Based Case-Control Study Medicina (IF 2.948) Pub Date : 2024-03-14 Pablo Román, Cristofer Ruiz-González, Lola Rueda-Ruzafa, Diana Cardona, Mar Requena, Raquel Alarcón
Background and Objectives: Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by challenges in communication, social interactions, and repetitive behaviors. Although the factors that influence the development of this condition are unknown, certain chemical compounds such as pesticides have been proposed as possible contributors. Due to the lack of an established causal link
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Exercise May Increase Oxidative Stress in the Sciatic Nerve in Streptozotocin-Induced Diabetic Rats Medicina (IF 2.948) Pub Date : 2024-03-14 Koji Nonaka, Junichi Akiyama, Satsuki Une
Background and Objectives: Diabetic peripheral neuropathy (DPN) affects approximately half of patients with diabetes mellitus (DM), contributing to falls and fractures. Oxidative stress, which is linked to DM-induced hyperglycemia, has been implicated in the onset of DPN. Although exercise is recommended for patients with DM, its effect on DPN remains unclear. Therefore, this study aimed to investigate
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Assessing the Effect of Enzymatic Debridement on the Scar Quality in Partial-Thickness Burns to Deep Dermal Burns of the Hand: A Long-Term Evaluation Medicina (IF 2.948) Pub Date : 2024-03-14 Wolfram Heitzmann, Alexandra Schulz, Paul Christian Fuchs, Jennifer Lynn Schiefer
Background and Objectives: Burn surgery on the hands is a difficult procedure due to the complex anatomy and fragility of the area. Enzymatic debridement has been shown to effectively remove burn eschar while minimizing damage to the surrounding tissue and has therefore become a standard procedure in many burn centers worldwide over the past decade. However, surprisingly, our recent literature review
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Evaluating the Clinical Utility of Brachial Plexus Block for Reducing Opioid Exposure in Pediatric Elbow Fracture Surgery: A Retrospective Cohort Study Medicina (IF 2.948) Pub Date : 2024-03-14 Kunhyung Bae, Yeon Ju Kim, Hyo Won Lim, Michael Seougcheol Kang, Ha-Jung Kim, Won Uk Koh, Young-jin Ro, Jooyeon Cho, Hwa Jung Kim, Soo-Sung Park, Yoon Hae Kwak, Hyungtae Kim
Background and Objectives: Reducing opioid exposure in common pediatric surgeries is of paramount importance. This study aimed to assess the efficacy of regional nerve blocks in reducing opioid exposure while preserving high success rates. Materials and Methods: We conducted a retrospective matched cohort study (1:1) including patients with elbow fractures < 12 years old who underwent treatment with
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The Association between Red Blood Cell Distribution Width and Mortality Risk after Hip Fracture: A Meta-Analysis Medicina (IF 2.948) Pub Date : 2024-03-14 Bao Tu Thai Nguyen, Duy Nguyen Anh Tran, Tan Thanh Nguyen, Yi-Jie Kuo, Yu-Pin Chen
Background and Objectives: Hip fractures in the elderly pose a considerable health risk and cause concern. Red blood cell distribution width (RDW) is a valuable marker for identifying patients at high risk of age-related mortality and various disorders and diseases. However, its association with poor patient outcomes following hip fractures has yet to be fully established. Hence, the purpose of this
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Intravenous Vitamin C as an Add-on Therapy for the Treatment of Sepsis in an Intensive Care Unit: A Prospective Cohort Study Medicina (IF 2.948) Pub Date : 2024-03-12 Sergio Antonio Gonzalez-Vazquez, Eli Efrain Gomez-Ramirez, Laura Gonzalez-Lopez, Jorge Ivan Gamez-Nava, Juan Angel Peraza-Zaldivar, Aline Priscilla Santiago-Garcia, Melissa Ramirez-Villafaña, Fabiola Gonzalez-Ponce, Jose Jorge Gomez-Camarena, Ana Miriam Saldaña-Cruz, Norma Alejandra Rodriguez-Jimenez, J. Ahuixotl Gutierrez-Aceves, Adriana Jimenez-Lopez, Sylvia Elena Totsuka-Sutto, Ernesto German Cardona-Muñoz
Background and Objectives: According to the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3), sepsis is defined as “life-threatening organ dysfunction caused by a dysregulated host response to infection”. The increased presence of free radicals causes an increase in oxidative stress. Vitamin C is an essential water-soluble vitamin with antioxidant activity and immunoregulatory
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Metaphedrone (3-Methylmethcathinone): Pharmacological, Clinical, and Toxicological Profile Medicina (IF 2.948) Pub Date : 2024-03-12 Igor Kelečević, Ana-Marija Vejnović, Jovan Javorac, Nemanja Gvozdenović, Nataša Janjić, Vesna Mijatović Jovin
Introduction: Synthetic cathinones are a group of novel psychoactive substances used as an alternative to classical recreational drugs. As a result of legal prohibitions on older generations of these compounds, new formulations appeared on the drug market. One of them is metaphedrone (3-methylmethcathinone, 3-MMC), a structural isomer of 4-methylmethcathinone and a psychostimulant drug. Metaphedrone
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Evaluating Knowledge, Self-Reported Confidence Levels, and Prescription Patterns among Dental Practitioners Regarding Analgesics in Dentistry: A Cross-Sectional Study Medicina (IF 2.948) Pub Date : 2024-03-12 Marija Badrov, Antonija Tadin
Background and Objectives: Dental pain is a common problem that often leads to unscheduled dental visits and requires a comprehensive understanding of analgesics, including their indications and contraindications. The aim of this study was to investigate dentists’ knowledge, self-reported confidence levels, and prescribing patterns of analgesics in dentistry. Materials and Methods: A nationwide cross-sectional
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Italian Survey on Endoscopic Biliary Drainage Approach in Patients with Surgically Altered Anatomy Medicina (IF 2.948) Pub Date : 2024-03-13 Aurelio Mauro, Cecilia Binda, Alessandro Fugazza, Giuseppe Vanella, Vincenzo Giorgio Mirante, Stefano Mazza, Davide Scalvini, Ilaria Tarantino, Carlo Fabbri, Andrea Anderloni, on behalf of the i-EUS Group
Background and Objectives: Biliary drainage (BD) in patients with surgically altered anatomy (SAA) could be obtained endoscopically with different techniques or with a percutaneous approach. Every endoscopic technique could be challenging and not clearly superior over another. The aim of this survey is to explore which is the standard BD approach in patients with SAA. Materials and Methods: A 34-question
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New Perspectives in Third Molar Auto-Transplantation: Literature Review and a Case Report of Clinical, Financial and Forensic Implications Medicina (IF 2.948) Pub Date : 2024-03-13 Alessandra Putrino, Enrico Marinelli, Alessandro Agrillo, Simona Zaami
Third molar extraction is the most common procedure in oral and maxillofacial surgery. Third molars are considered less functional than other teeth and are often extracted. Sometimes, they are also used for auto-transplantation for the benefit of oral rehabilitation. Since many biological factors are involved in this surgical approach, herein, we outline a review of the biological characteristics of
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Sex Differences in Insomnia and Circadian Rhythm Disorders: A Systematic Review Medicina (IF 2.948) Pub Date : 2024-03-13 Evelina Pajėdienė, Viltė Urbonavičiūtė, Vita Ramanauskaitė, Lukas Strazdauskas, Ambra Stefani
Insomnia and circadian rhythm disorders are increasingly common in modern society and lead to significant challenges for people’s health and well-being. Some studies suggests that men and women differ in neurohormonal secretion, biological processes, and brain morphology. Thus, such differences may affect the etiology, manifestation, and course of sleep disorders, including insomnia and circadian rhythm
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Environmental Exposure to Pesticides and the Risk of Child Neurodevelopmental Disorders Medicina (IF 2.948) Pub Date : 2024-03-13 Rocio Parrón-Carrillo, Bruno José Nievas-Soriano, Tesifón Parrón-Carreño, David Lozano-Paniagua, Rubén Trigueros
Background and Objectives: Neurodevelopment is a fragile brain process necessary for learning from the beginning of childhood to adulthood. During the procedure, several risks could affect it, including environmental factors such as neurotoxic chemicals or environmental pollutants and, within them, exposure to pesticides. Materials and Methods: This ecological descriptive study attempted to assess
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Balloon Pulmonary Angioplasty for Inoperable Chronic Thromboembolic Pulmonary Hypertension: Insights from a Pilot Low-Volume Centre Study and a Comparative Analysis with Other Centres Medicina (IF 2.948) Pub Date : 2024-03-11 Taida Ivanauskiene, Sigitas Cesna, Egle Grigoniene, Lina Gumbiene, Aurelija Daubaraite, Kaste Ivanauskaite, Sigita Glaveckaite
Background and Objectives: The aim of this study was to evaluate the effectiveness and safety of balloon pulmonary angioplasty (BPA) in patients with inoperable chronic thromboembolic pulmonary hypertension (CTEPH) in the Vilnius Pulmonary Hypertension (PH) Referral Centre and to provide a comparative analysis with other centres. Materials and Methods: This study included all BPA procedures performed
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Preoperative Age and Its Impact on Long-Term Renal Functional Decline after Robotic-Assisted Partial Nephrectomy: Insights from a Tertiary Referral Center Medicina (IF 2.948) Pub Date : 2024-03-11 Cesare Saitta, Giuseppe Garofano, Giovanni Lughezzani, Margaret F. Meagher, Kit L. Yuen, Vittorio Fasulo, Pietro Diana, Alessandro Uleri, Andrea Piccolini, Stefano Mancon, Paola Arena, Federica Sordelli, Matilde Mantovani, Pier Paolo Avolio, Edoardo Beatrici, Rodolfo F. Hurle, Massimo Lazzeri, Alberto Saita, Paolo Casale, Ithaar H. Derweesh, Marco Paciotti, Nicolò M. Buffi
Background and Objectives: to investigate the impact of age on renal function deterioration after robotic-assisted partial nephrectomy (RAPN) focusing on a decline to moderate and severe forms of chronic kidney disease (CKD). Materials and Methods: This is a single center prospective analysis of patients who underwent RAPN. The outcomes include the development of de novo CKD-S 3a [estimated glomerular
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Diagnostic Challenges in Inflammatory Choroidal Neovascularization Medicina (IF 2.948) Pub Date : 2024-03-12 Izabella Karska-Basta, Weronika Pociej-Marciak, Katarzyna Żuber-Łaskawiec, Anna Markiewicz, Michał Chrząszcz, Bożena Romanowska-Dixon, Agnieszka Kubicka-Trząska
Inflammation plays a key role in the induction of choroidal neovascularization (CNV). Inflammatory choroidal neovascularization (iCNV) is a severe but uncommon complication of both infectious and non-infectious uveitides. It is hypothesized that its pathogenesis is similar to that of wet age-related macular degeneration (AMD), and involves hypoxia as well as the release of vascular endothelial growth
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Frequency of Thyroid Microcarcinoma in Patients Who Underwent Total Thyroidectomy with Benign Indication—A 5-Year Retrospective Review Medicina (IF 2.948) Pub Date : 2024-03-12 Vasiliki Magra, Kassiani Boulogeorgou, Eleni Paschou, Christina Sevva, Vasiliki Manaki, Ioanna Mpotani, Stylianos Mantalovas, Styliani Laskou, Isaak Kesisoglou, Triantafyllia Koletsa, Konstantinos Sapalidis
Background and Objectives: Incidental thyroid cancers (ITCs) are often microcarcinomas. The most frequent histologic type is a papillary microcarcinoma. Papillary thyroid microcarcinomas are defined as papillary thyroid tumours measuring less than 10 mm at their greatest diameter. They are clinically occult and frequently diagnosed incidentally in histopathology reports after a thyroidectomy. The aim
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Ruptured Ovarian Cystic Teratoma: A Rare Diagnosis, Easily to Be Confused with Peritoneal Carcinomatosis Medicina (IF 2.948) Pub Date : 2024-03-10 Dan Costachescu, Alexandru Catalin Motofelea, Daniel Malita, Florica Birsasteanu, Ioana Ionita, Nadica Motofelea, Cristina Ana-Maria Jura, Ioana-Flavia Bacila, Mihai Bacila, Sorin Motoi
Although ovarian cystic teratoma is the most common ovarian tumor, complications are quite rare. However, it is important to be recognized by the radiologist in order to avoid inaccurately diagnosing them as malignant lesions. This case report describes a 61-year-old postmenopausal woman, who presented to the emergency room with abdominal pain following a minor blunt abdominal trauma. In this context
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Musculoskeletal Pain, Physical Activity, Muscle Mass, and Mortality in Older Adults: Results from the Korean Longitudinal Study on Health and Aging (KLoSHA) Medicina (IF 2.948) Pub Date : 2024-03-11 Sun-Woo Hwang, Chang-Woo Kim, Yun-Jeong Jang, Chang-Han Lee, Min-Kyun Oh, Ki-Woong Kim, Hak-Chul Jang, Jae-Young Lim, Se-Woong Chun, Seung-Kyu Lim
Background and objectives: Musculoskeletal (MSK) pain significantly impacts physical activity and quality of life in older adults, potentially influencing mortality. This study explored the relationship between MSK pain, physical activity, muscle mass, and mortality among older adults. Material and Methods: We studied 1000 participants in the Korean Longitudinal Study on Health and Aging (KLoSHA),
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Relationship between Sociodemographic and Health-Related Factors and Sedentary Time in Middle-Aged and Older Adults in Taiwan Medicina (IF 2.948) Pub Date : 2024-03-08 Hung-Chin Huang, Shao-Hsi Chang, Xiaolin Yang
Background and Objectives: This study aimed to investigate the associations between sociodemographic and health-related factors and sedentary time in middle-aged and older Taiwanese adults. Materials and Methods: A total of 1031 participants (460 men, 571 women; mean age 65.0 years ± 7.8 years; range 55 to 93 years) were randomly recruited from the National Computer Assessment Telephone Interview,
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Lower Arginine Bioavailability, Increased FeNO Levels, and Airway Resistance on Impulse Oscillometry Are Characteristics of Asthma in Children and Young Adults with Sickle Cell Disease Medicina (IF 2.948) Pub Date : 2024-03-08 Aylin Kont Ozhan, Tugba Arikoglu, Melih Er, Selma Unal, Didem Derici Yıldırım, Funda Erkasar, Şenay Balcı, Lulufer Tamer, Semanur Kuyucu
Background and Objectives: Data on characteristics of asthma in children with sickle cell disease (SCD) is conflicting. Recently, the L-arginine pathway has gained attention in the pathogenesis of asthma and SCD. This study aimed to determine the distinctive clinical and laboratory features and the role of arginine metabolism in asthmatic children with SCD. Materials and Methods: A total of 52 children
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The Association of Acetabulum Fracture and Mechanism of Injury with BMI, Days Spent in Hospital, Blood Loss, and Surgery Time: A Retrospective Analysis of 67 Patients Medicina (IF 2.948) Pub Date : 2024-03-09 Rafał Wójcicki, Tomasz Pielak, Piotr Marcin Walus, Łukasz Jaworski, Bartłomiej Małkowski, Przemysław Jasiewicz, Maciej Gagat, Łukasz Łapaj, Jan Zabrzyński
Background and Objectives: The objective of this retrospective study was to investigate the association between acetabulum fractures; the mechanism of injury; and variables such as BMI, duration of hospital stay, blood loss, and surgery time. By exploring these factors, we aim to enhance our understanding of them and their impact on the healing process and the subsequent management of pelvic fractures
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Gross Taper Failure and Fracture of the True Neck in Total Hip Arthroplasty: Retrieval Scanning Electron Microscope Analysis Medicina (IF 2.948) Pub Date : 2024-03-09 Corrado Ciatti, Michelangelo Moschella, Edoardo Bori, Carlo Doria, Gianfilippo Caggiari, Bernardo Innocenti, Francesco Pisanu
Background and objectives: wear and corrosion can lead to the gross failure of the Morse taper junction with the consequent fracture of the true neck of the prosthetic stem in hip arthroplasty. Materials and Methods: 58-year-old male patient, with a BMI of 38 kg/m2. Because of avascular necrosis, in 2007, a metal-on-metal total hip arthroplasty was implanted in him, with a TMZF stem and a Co-Cr head
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Therapeutic Impact of Aerobic Exercise on Adolescents with Obesity and Its Association with Expression of miRNAs and Cytokines: A Clinical Approach Medicina (IF 2.948) Pub Date : 2024-03-10 Petricia Hillari Raj, Prasanth Subramanian, Mohanraj Nehru, Saravanan Ayyavoo, Nachal Annamalai, Venkataraman Prabhu
Background and Objectives: MicroRNAs are short noncoding RNAs that play an essential role in controlling gene expression at the posttranscriptional level. They can serve as biomarkers in the management of obesity. Circulating miRNAs levels change with exercise, impacting various physiological and biological systems, including structural and functional changes. Aim: The purpose of this study is to evaluate
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Higher C-Reactive Protein to Albumin Ratio Portends Long-Term Mortality in Patients with Chronic Heart Failure and Reduced Ejection Fraction Medicina (IF 2.948) Pub Date : 2024-03-07 Veysel Ozan Tanık, Evliya Akdeniz, Tufan Çınar, Barış Şimşek, Duygu İnan, Ahmet Kıvrak, Yavuz Karabağ, Metin Çağdaş, Kamuran Kalkan, Can Yücel Karabay, Bülent Özlek
Background and Objectives: In this study, we aimed to investigate the prognostic value of the C-reactive protein to albumin ratio (CAR) for all-cause mortality in patients with chronic heart failure with reduced ejection fraction (HFrEF). Materials and Methods: In total, 404 chronic HFrEF patients were included in this observational and retrospective study. The CAR value of each patient included in
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Integrating Retrieval-Augmented Generation with Large Language Models in Nephrology: Advancing Practical Applications Medicina (IF 2.948) Pub Date : 2024-03-08 Jing Miao, Charat Thongprayoon, Supawadee Suppadungsuk, Oscar A. Garcia Valencia, Wisit Cheungpasitporn
The integration of large language models (LLMs) into healthcare, particularly in nephrology, represents a significant advancement in applying advanced technology to patient care, medical research, and education. These advanced models have progressed from simple text processors to tools capable of deep language understanding, offering innovative ways to handle health-related data, thus improving medical
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Transforaminal Epidural Block and Erector Spinae Plane Block to Manage Acute Zoster-Associated Pain: A Retrospective Case–Control Study Medicina (IF 2.948) Pub Date : 2024-03-09 Hyojung Soh, Yeona Ko, Jungwon Shin, Eung Don Kim
Background and Objectives: Achieving adequate pain reduction in the acute phase of herpes zoster is essential for preventing postherpetic neuralgia (PHN). For this purpose, appropriate antiviral medications, oral analgesic medications, and various nerve block methods could be applied. Erector spinae plane block (ESPB) is a simple, novel ultrasound-guided block technique, and its use has increased because
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Short-Term Changes in Weather Conditions and the Risk of Acute Coronary Syndrome Hospitalization with and without ST-Segment Elevation: A Focus on Vulnerable Subgroups Medicina (IF 2.948) Pub Date : 2024-03-09 Andreea-Alexandra Rus, Mihai-Andrei Lazăr, Romeo Negrea, Alina-Ramona Cozlac, Cristina Văcărescu, Raluca Şoşdean, Silvia-Ana Luca, Dan Gaiţă, Cristian Mornoş
Background and Objectives: Acute coronary syndrome (ACS), a prevalent global cardiovascular disease and leading cause of mortality, is significantly correlated with meteorological factors. This study aims to analyze the impact of short-term changes in meteorological factors on the risk of ACS, both with and without ST-segment elevation, and to identify vulnerable subgroups. Materials and Methods: Daily
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Takayasu’s Arteritis: A Special Case Report and Review of the Literature Medicina (IF 2.948) Pub Date : 2024-03-09 Paloma Moisii, Irina Jari, Alexandru Gratian Naum, Doina Butcovan, Grigore Tinica
Background: Takayasu’s arteritis is a rare type of vasculitis with severe complications like stroke, ischemic heart disease, pulmonary hypertension, secondary hypertension, and aneurysms. Diagnosis is achieved using clinical and angiographic criteria. Treatment is medical and surgical, but unfortunately, the outcome is limited. Case presentation: A 34-year-old Caucasian woman had an ischemic stroke
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Sports Activities in Children with Cerebral Palsy: A Narrative Review Medicina (IF 2.948) Pub Date : 2024-03-09 Domenico M. Romeo, Giulia D’Amario, Giulia Brunozzi, Valentina Napoli, Marianna Villa, Chiara Arpaia, Chiara Velli, Francesca Sini, Claudia Brogna
Physical exercise is known to have beneficial effects on psychosocial well-being and cognitive performance. Children with cerebral palsy (CP) showed lower levels of physical activity (PA) than healthy children; this fact, in addition to the basic clinical condition, increased the sedentary habit with a psychological impact and motor impairment of these children. Furthermore, children and adolescents
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Seroprevalence Study of Anti-HBs Antibodies in the General Population of Vojvodina, Serbia Medicina (IF 2.948) Pub Date : 2024-03-06 Smiljana Rajčević, Snežana Medić, Aleksandra Patić, Nataša Dragnić, Mioljub Ristić, Vladimir Vuković, Vladimir Petrović
Background and Objectives: Hepatitis B (HB) is a major global health problem and a potentially life-threatening disease caused by the hepatitis B virus (HBV). Also, it is an important cause of morbidity and mortality worldwide. Thanks to serological surveys, testing hepatitis B surface antibodies (anti-HBs) allows for serological assessments of their prevalence. The presence of anti-HBs, which protects
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Systemic Immune-Inflammation Index in Relation to Diabetes Markers in Saudi Adults: A Retrospective Study Medicina (IF 2.948) Pub Date : 2024-03-07 Ghadeer S. Aljuraiban, Fahad J. Alharbi, Ali O. Aljohi, Abdullah Z. Almeshari, Masoud N. Alotaibi, Salem S. AlShammari, Sara Al-Musharaf, Madhawi M. Aldhwayan, Manal Abudawood
Background and objectives: Low-grade inflammation is associated with metabolic disturbances like diabetes. The systemic immune-inflammation index (SII) has been proposed as a predictive tool to identify individuals at a greater risk of diabetes. This study aims to examine the association between SII and diabetes markers. Method and materials: We used retrospective data from a large cohort of adults
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Local Oxygen-Based Therapy (blue®m) for Treatment of Peri-Implant Disease: Clinical Case Presentation and Review of Literature about Conventional Local Adjunct Therapies Medicina (IF 2.948) Pub Date : 2024-03-08 Marwa Y. Shaheen, Irfan Abas, Amani M. Basudan, Hamdan S. Alghamdi
Peri-implant diseases including peri-implant mucositis and peri-implantitis are among the major causes of failure of implant-supported dental restorations. They are characterized by progressive inflammation of the peri-implant mucosa, extending to the surrounding connective tissues and leading to bone loss and implant failure. Although strict oral hygiene practices help in preventing peri-implant diseases
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The Effectiveness of Biological Agents on Chronic Rhinosinusitis with Nasal Polyposis in Patients with Comorbid Asthma: A Multicenter Real-Life Study from Türkiye Medicina (IF 2.948) Pub Date : 2024-03-08 Meryem Demir, Ceyda Tunakan Dalgic, Emine Nihal Mete Gokmen, Recep Savas, Suleyman Eroglu, Guzin Ozden, Cihan Orcen, Gulden Pacaci Cetin, Bahar Arslan, Ferda Bilgir, Gokten Bulut, Nurullah Yekta Akcam, Semiha Ozgul, Pamir Cerci, Raif Coskun, Sercan Gode, Insu Yilmaz, Aytul Zerrin Sin
Background and Objectives: Real-life data on the efficacy of biologic agents (BAs) on asthma-comorbid CRSwNP are needed. Our primary goal is to investigate the effects of BAs on CRSwNP symptoms, as well as endoscopic and tomography scores. Our secondary goal is to show a reduction in the frequency of acute sinusitis exacerbations and the need for surgery. Materials and Methods: We conducted a multicenter
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Hepatic Hemangioma: Review of Imaging and Therapeutic Strategies Medicina (IF 2.948) Pub Date : 2024-03-08 Arkadiusz Kacała, Mateusz Dorochowicz, Iwona Matus, Michał Puła, Adrian Korbecki, Michał Sobański, Jagoda Jacków-Nowicka, Dariusz Patrzałek, Dariusz Janczak, Maciej Guziński
Hepatic hemangiomas are the most common benign liver tumors. Typically, small- to medium-sized hemangiomas are asymptomatic and discovered incidentally through the widespread use of imaging techniques. Giant hemangiomas (>5 cm) have a higher risk of complications. A variety of imaging methods are used for diagnosis. Cavernous hemangioma is the most frequent type, but radiologists must be aware of other
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Effects of Switching from Degludec to Glargine U300 in Patients with Insulin-Dependent Type 1 Diabetes: A Retrospective Study Medicina (IF 2.948) Pub Date : 2024-03-08 Toshitaka Sawamura, Shigehiro Karashima, Azusa Ohbatake, Takuya Higashitani, Ai Ohmori, Kei Sawada, Rika Yamamoto, Mitsuhiro Kometani, Yuko Katsuda, Takashi Yoneda
Background and Objectives: Degludec (Deg) and glargine U300 (Gla-300) are insulin analogs with longer and smoother pharmacodynamic action than glargine U100 (Gla-100), a long-acting insulin that has been widely used for many years in type 1 and type 2 diabetes. Both improve glycemic variability (GV) and the frequency of hypoglycemia, unlike Gla-100. However, it is unclear which insulin analog affects
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Effective Differences between 2D and 3D Planned Brachytherapy in Lung Cancer: An Institutional Retrospective Study Medicina (IF 2.948) Pub Date : 2024-03-08 Nensi Lalić, Marko Bojović, Olivera Ivanov, Jelena Ličina, Spasoje Popević, Mihailo Stjepanović, Daliborka Bursać, Ivica Lalić, Rade Milić, Sanja Tomić, Biljana Parapid, Aleksandar Anđelković
Background and Objectives: Advanced lung cancer is usually manifested by endoluminal tumor propagation, resulting in central airway obstruction. The objective of this study is to compare the high dose rate brachytherapy treatment outcomes in non-small-cell lung cancer (NSCLC) depending on the treatment planning pattern—two-dimension (2D) or three-dimension (3D) treatment planning. Materials and Methods:
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Regeneration of Rabbit Calvarial Defects with Combination of Stem Cells and Enamel Matrix Derivative: A Microcomputed Tomography and Histological Evaluation Comparing Two- and Three-Dimensional Cell Constructs Medicina (IF 2.948) Pub Date : 2024-03-08 Kyung-Hwan Na, Hyun-Jin Lee, Ji-Eun Lee, Jun-Beom Park
Background and Objectives: This study addresses the challenge of bone regeneration in calvarial defects, exploring the efficacy of stem cell-based therapies and enamel matrix derivative (EMD) in tissue engineering. It assesses the regenerative potential of two- and three-dimensional cell constructs combined with mesenchymal stem cells (MSCs) and EMD in rabbit calvarial defects. Materials and Methods:
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Sepsis-Associated Acute Kidney Injury: Where Are We Now? Medicina (IF 2.948) Pub Date : 2024-03-06 Dimitris Kounatidis, Natalia G. Vallianou, Sotiria Psallida, Fotis Panagopoulos, Evangelia Margellou, Dimitrios Tsilingiris, Irene Karampela, Theodora Stratigou, Maria Dalamaga
Worldwide, sepsis is a well-recognized cause of death. Acute kidney injury (AKI) may be related to sepsis in up to 70% of AKI cases. Sepsis-associated AKI (SA-AKI) is defined as the presence of AKI according to the Kidney Disease: Improving Global Outcomes criteria in the context of sepsis. SA-AKI is categorized into early, which presents during the first 48 h of sepsis, and late, presenting between
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Apraxia Patterns for the Differentiation between Alzheimer’s Disease and Frontotemporal Dementia Variants Medicina (IF 2.948) Pub Date : 2024-03-06 Georgios Papadopoulos, Dimitrios Parissis, Anna Gotzamani-Psarrakou, Panagiotis Ioannidis
Background and Objectives: Despite the increasing use of biomarkers, differentiation between Alzheimer’s disease (AD), behavioral variant Frontotemporal Dementia (bvFTD), and Primary Progressive Aphasia (PPA) remains a challenge. Apraxia is a supportive feature for diagnosing AD but is underrepresented in other dementia types. Herein, we investigated the presence and characteristic profiles of limb
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Laser Therapy Effects on Periodontal Status: A Randomized Study Using Gaussian Network Analysis and Structural Equation Modeling Approach Medicina (IF 2.948) Pub Date : 2024-03-06 Codruta Elena Ciurescu, Lorena Dima, Vlad Alexandru Ciurescu, Gratiela Georgiana Noja, Alin Viorel Istodor, Marius Alexandru Moga, Lavinia Cosmina Ardelean, Laura-Cristina Rusu, Marius Traian Leretter
Background and Objectives: This paper aims to assess the role of laser therapy in periodontitis through an innovative approach involving computational prediction and advanced modeling performed through network analysis (Gaussian graphical models—GGMs) and structural equations (SEM). Materials and Methods: Forty patients, exhibiting periodontal pockets with a minimum depth of 5 mm, were randomly divided
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Unlocking the Dietary Puzzle: How Macronutrient Intake Shapes the Relationship between Visfatin and Atherosclerosis in Type 2 Diabetes Medicina (IF 2.948) Pub Date : 2024-03-06 Kati Kärberg, Alastair Forbes, Margus Lember
Background and Objectives. Optimal nutrition for type 2 diabetes (T2DM) aims to improve glycemic control by promoting weight loss and reducing adipose tissue, consequently improving cardiovascular health. Dietary alterations can influence adipose tissue metabolism and potentially impact adipocytokines like visfatin, thereby affecting atherosclerosis development. This study aimed to investigate dietary
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Idiopathic Spontaneous Rupture of a Subcostal Artery in a Patient Undergoing Hemodialysis: A Case Report Medicina (IF 2.948) Pub Date : 2024-03-07 Junha Ryu, Seolje Lee, Tae Won Lee, Eunjin Bae, Dong Jun Park
The spontaneous rupture of a subcostal (12th intercostal) artery is exceptionally rare and could be fatal, requiring early diagnosis and treatment. Only one case of intercostal artery (ICA) bleeding in a patient undergoing hemodialysis (HD) has been reported. We additionally describe a 41-year-old man undergoing HD who presented with a spontaneous hemoperitoneum and shock resulting from a subcostal
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In Vitro Assessment of the Neuro-Compatibility of Fe-20Mn as a Potential Bioresorbable Material for Craniofacial Surgery Medicina (IF 2.948) Pub Date : 2024-03-07 Sara Ajami, Charlotte Kraaneveld, Maarten Koudstaal, David Dunaway, Noor Ul Owase Jeelani, Silvia Schievano, Chiara Bregoli, Jacopo Fiocchi, Carlo Alberto Biffi, Ausonio Tuissi, Alessandro Borghi
Background and Objectives: Spring-assisted surgery is a popular option for the treatment of non-syndromic craniosynostosis. The main drawback of this procedure is the need for a second surgery for spring removal, which could be avoided if a distractor material could be metabolised over time. Iron–Manganese alloys (FeMn) have a good trade-off between degradation rate and strength; however, their biocompatibility
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Sex Differences in Short- and Long-Term Survival after Acute Type A Aortic Dissection Medicina (IF 2.948) Pub Date : 2024-03-07 Philipp Pfeiffer, Lena Brendel, Romina Maria Rösch, Chris Probst, Ahmed Ghazy, Edoardo Zancanaro, Hazem El Beyrouti, Hendrik Treede, Daniel-Sebastian Dohle
Background and Objectives: Acute type A aortic dissection (AAD) is a life-threatening disease. No differences between men and women have been made in the treatment of AAD so far and knowledge about sex differences regarding long-term outcomes is limited. Materials and Methods: Between 01/2004 and 12/2021, 874 patients were operated on for AAD, including 313 (35.8%) women and 561 (64.2%) men. Clinical
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Pilot Study of the Total and Phosphorylated Tau Proteins in Early-Stage Multiple Sclerosis Medicina (IF 2.948) Pub Date : 2024-02-29 Ieva Masiulienė, Katryna Pampuščenko, Gintarė Žemgulytė, Diana Bilskienė, Vilmantė Borutaitė, Renata Balnytė
Background and Objectives: Recent findings suggest that neurodegeneration starts early in the course of multiple sclerosis (MS) and significantly contributes to the progression of patients’ disability. Tau is a microtubule-binding protein that is known to play a role in the pathophysiology of many neurodegenerative disorders. Newly emerging data on tau protein-induced neurodegenerative processes and
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Global Patterns of Trends in Incidence and Mortality of Dengue, 1990–2019: An Analysis Based on the Global Burden of Disease Study Medicina (IF 2.948) Pub Date : 2024-03-01 Irena Ilic, Milena Ilic
Background and Objectives: Dengue is an important public health concern that warrants an examination of the longer-term global trends of its disease burden. The aim of this study was to assess the trends in dengue incidence and mortality worldwide over the last three decades. Materials and Methods: A descriptive epidemiological study was carried out, investigating the trends in the incidence and mortality
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Current Global Trends in Prepectoral Breast Reconstruction Medicina (IF 2.948) Pub Date : 2024-03-03 Saima Taj, Ravi Chandavarkar, Raghavan Vidya
Implant-based breast reconstruction (IBBR) is the most frequently performed procedure for breast reconstruction following mastectomy, which involves the surgical placement of breast implants. The approach to breast reconstruction can be divided into two main categories, namely prepectoral breast reconstruction (PPBR) and subpectoral breast reconstruction (SPBR), based on the implant plan and placement