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Primary Thromboprophylaxis for the Prevention of Venous Thromboembolism in Cancer Patients with Central Venous Catheters: A Literature Review J. Clin. Med. (IF 3.9) Pub Date : 2024-03-14 Hikmat Abdel-Razeq, Mohammed J. Al-Jaghbeer
Cancer is a known risk factor for venous thromboembolism (VTE). The wider adoption of immunotherapy and anti-angiogenic drugs in recent years have increased this risk further. Central venous catheters (CVCs) are widely used access devices utilized to deliver infusion therapy, mostly in ambulatory settings. The endothelial injury associated with the use of these catheters adds to the risk of VTE to
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Cardiac Rehabilitation Increases Plasma Klotho Levels J. Clin. Med. (IF 3.9) Pub Date : 2024-03-14 Ana María Pello Lázaro, Koldo Villelabeitia Jaureguizar, Juan Antonio Franco Peláez, Ana Venegas-Rodriguez, Álvaro Aceña, Andrea Kallmeyer, Ester Cánovas, María Luisa González-Casaus, Nieves Tarín, Carmen Cristóbal, Carlos Gutiérrez-Landaluce, Ana Huelmos, Óscar González-Lorenzo, Joaquín Alonso, Lorenzo López-Bescós, Jesús Egido, Ignacio Mahillo-Fernández, Jairo Lumpuy-Castillo, Óscar Lorenzo, José
Background: Mineral metabolism (MM), mainly fibroblast growth factor-23 (FGF-23) and klotho, has been linked to cardiovascular (CV) diseases. Cardiac rehabilitation (CR) has been demonstrated to reduce CV events, although its potential relationship with changes in MM is unknown. Methods: We performed a prospective, observational, case-control study, with acute coronary syndrome (ACS) patients who underwent
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The Difficulty of Detecting Occult Metastases in Patients with Potentially Resectable Pancreatic Cancer: Development and External Validation of a Preoperative Prediction Model J. Clin. Med. (IF 3.9) Pub Date : 2024-03-14 Marieke Walma, Laura Maggino, F. Jasmijn Smits, Alicia S. Borggreve, Lois A. Daamen, Vincent P. Groot, Fabio Casciani, Vincent E. de Meijer, Frank J. Wessels, George P. van der Schelling, Vincent B. Nieuwenhuijs, Koop Bosscha, Erwin van der Harst, Ronald van Dam, Mike S. Liem, Sebastiaan Festen, Martijn W. J. Stommel, Daphne Roos, Fennie Wit, Ignace H. de Hingh, Bert A. Bonsing, Olivier R. Busch, Bas
Occult metastases are detected in 10–15% of patients during exploratory laparotomy for pancreatic cancer. This study developed and externally validated a model to predict occult metastases in patients with potentially resectable pancreatic cancer. Model development was performed within the Dutch Pancreatic Cancer Audit, including all patients operated for pancreatic cancer (January 2013–December 2017)
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Inflammatory Cytokines Associated with Obesity, Type-2 Diabetes, and Hypertension Exacerbate Breast Cancer Risk in Underserved African American and Latin American Women J. Clin. Med. (IF 3.9) Pub Date : 2024-03-15 Yanyuan Wu, Eduard Karapetyan, Pranabananda Dutta, Magda Shaheen, Jaydutt V. Vadgama
Background: Comorbid chronic diseases, such as obesity, Type-2 Diabetes (T2D), and hypertension (HTN), are major public health issues and highly prevalent among underserved African Americans (AA) and Latin Americans (LA). Elevated inflammatory cytokines are underlying processes in comorbidities (obesity, T2D, and HTN) that could contribute to tumorigenesis and adverse cancer outcomes. Methods: A panel
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Insomnia in Forensic Detainees: Is Salience Network the Common Pathway for Sleep, Neuropsychiatric, and Neurodegenerative Disorders? J. Clin. Med. (IF 3.9) Pub Date : 2024-03-15 Adonis Sfera, Kyle A. Thomas, Isaac A. Ogunjale, Nyla Jafri, Peter G. Bota
Forensic hospitals throughout the country house individuals with severe mental illness and history of criminal violations. Insomnia affects 67.4% of hospitalized patients with chronic neuropsychiatric disorders, indicating that these conditions may hijack human somnogenic pathways. Conversely, somnolence is a common adverse effect of many antipsychotic drugs, further highlighting a common etiopathogenesis
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Surgical Management of Chiari 1.5 in Children: A Truly Different Disease? J. Clin. Med. (IF 3.9) Pub Date : 2024-03-15 Ignazio G. Vetrano, Arianna Barbotti, Tommaso Francesco Galbiati, Sabrina Mariani, Alessandra Erbetta, Luisa Chiapparini, Veronica Saletti, Laura G. Valentini
Background: In patients with Chiari 1.5 malformation (CM1.5), a more aggressive disease course and an increased association with craniovertebral junction (CVJ) anomalies has been suggested. The best management of this subgroup of patients is not clearly defined, also due to the lack of specific series elucidating this anomaly’s peculiar characteristics. Methods: We evaluated a series of 33 patients
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Revealing the Unseen: Detecting Negative Symptoms in Students J. Clin. Med. (IF 3.9) Pub Date : 2024-03-15 Lucie Métivier, Maxime Mauduy, Hélène Beaunieux, Sonia Dollfus
Background: The transnosographic nature of negative symptoms (NS) makes them fruitful for detecting psychiatric symptoms. The main objective of this study was to determine whether NS can be useful in screening for ultra-high risk of psychosis (UHR) or depressive symptoms in the no-help-seeking student population. The most prevalent NS and their relationship with cannabis use were also researched. Methods:
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Parenteral Anticoagulation at First Medical Contact Improves Infarct Related Artery Patency in STEMI J. Clin. Med. (IF 3.9) Pub Date : 2024-03-16 Vlad Bataila, Nicoleta-Monica Popa-Fotea, Cosmin Cojocaru, Lucian Calmac, Cosmin Mihai, Marian-Bogdan Dragoescu, Vlad Ploscaru, Mugur Marinescu, Vasile Iliese, Anamaria-Georgiana Avram, Raluca-Elena Mitran, Radu-Gabriel Vatasescu
(1) Background: Acute ST-segment elevation myocardial infarction (STEMI) remains one of the main morbidity and mortality contributors worldwide. Its main treatment, primary percutaneous coronary intervention (pPCI), can only be performed with a high anticoagulation regimen, usually with heparin. There is still not enough evidence regarding the timing of heparin administration. (2) Methods: We conducted
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Resistance Exercise Program Is Feasible and Effective in Improving Functional Strength in Post-COVID Survivors J. Clin. Med. (IF 3.9) Pub Date : 2024-03-16 Katarzyna Kaczmarczyk, Yogi Matharu, Patrycja Bobowik, Jan Gajewski, Agnieszka Maciejewska-Skrendo, Kornelia Kulig
Background: Evidence suggests that COVID-19 infection can cause lasting health consequences. Multidisciplinary rehabilitation services have been recommended to reduce the sequalae. However, the effectiveness of physical exercise interventions remains insufficiently documented. The aim of this study was to develop and implement a specific and well-tolerated protocol-based intervention to reduce muscle
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Early Breast Cancer: Could Combined LOCalizerTM and Ultrasound Localization Replace the Metallic Wire? A Multicentric Study J. Clin. Med. (IF 3.9) Pub Date : 2024-03-16 Simona Parisi, Claudio Gambardella, Antonio Santoriello, Roberto Ruggiero, Francesco Iovino, Francesca Fisone, Federico Maria Mongardini, Francesco Saverio Lucido, Salvatore Tolone, Ludovico Docimo
Background: Breast localization plays a key role in early breast cancer (BC) surgery. The current gold standard is wire-guided localization (WGL), despite the known disadvantages. The patients often experience anxiety and discomfort due the metallic wire placed in the breast, and surgeons are compelled to perform the surgery on the same day as the radiological release of the wire to prevent migrations
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Evaluation of Prehospital Undertriage in Relation to Trauma Team Activation—Results from a Prospective Study in 12 Level one German Trauma Centers J. Clin. Med. (IF 3.9) Pub Date : 2024-03-16 Helena Düsing, Paul Hagebusch, Markus Baacke, Dan Bieler, Michael Caspers, Valentin Clemens, Matthias Fröhlich, Lisa Hackenberg, Renè Hartensuer, Sebastian Imach, Kai Oliver Jensen, Annette Keß, Christian Kleber, Fabian Laue, Rolf Lefering, Mindaugas Maslauskas, Gerrit Matthes, André Nohl, Orkun Özkurtul, Thomas Paffrath, Vera Pedersen, Tristan Pfläging, Kai Sprengel, Philipp Störmann, Heiko Trentzsch
Background/Objective: This prospective, multicenter observational cohort study was carried out in 12 trauma centers in Germany and Switzerland. Its purpose was to evaluate the rate of undertriage, as well as potential consequences, and relate these with different Trauma Team Activation Protocols (TTA-Protocols), as this has not been done before in Germany. Methods: Each trauma center collected the
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Prevention of Cerebrospinal Fluid Leakage in the Anterior Transpetrosal Approach J. Clin. Med. (IF 3.9) Pub Date : 2024-03-16 Shunsuke Shibao, Kazunari Yoshida, Ryota Sasao, Masaaki Nishimoto
Background: The anterior transpetrosal approach (ATPA) is effective for reaching petroclival lesions, and it allows for complications such as impaired venous return and neuropathy to be resolved. However, there is still room for improvement regarding cerebrospinal fluid (CSF) leakage. Here, we aim to focus on describing specific preoperative, intraoperative, and postoperative countermeasures for preventing
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De Novo Metabolic Syndrome 1 Year after Liver Transplantation and Its Association with Mid- and Long-Term Morbidity and Mortality in Liver Recipients J. Clin. Med. (IF 3.9) Pub Date : 2024-03-16 Kinga Czarnecka, Paulina Czarnecka, Olga Tronina, Teresa Bączkowska, Magdalena Durlik
Background: Metabolic syndrome (MS) constitutes an important source of cardiovascular- and cancer-related morbidity and mortality in the general population. Limited information is available on whether these findings can be directly extrapolated to liver recipients. This study aimed to investigate the impact of post-transplant MS present 1 year after liver transplantation on survival rates, risk of
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May Spasticity-Related Unpleasant Sensations Interfere with Daily Activities in People with Stroke and Traumatic Brain Injury? Secondary Analysis from the CORTOX Study J. Clin. Med. (IF 3.9) Pub Date : 2024-03-16 Salvatore Facciorusso, Stefania Spina, Alessandro Picelli, Alessio Baricich, Franco Molteni, Andrea Santamato
Background/Objectives: This study examined the impact of spasticity-related unpleasant sensations (pain, heaviness, stiffness) on various domains of the International Classification of Functioning, Disability, and Health (ICF) and psychosocial well-being in individuals affected by stroke or traumatic brain injury (TBI). The primary aim is to explore how these sensations affect daily activities, participation
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Superficial Peritoneal Endometriosis Vaporization Using a CO2 Laser: A Long-Term Single-Center Experience J. Clin. Med. (IF 3.9) Pub Date : 2024-03-17 Stefano Di Michele, Silvia Bramante, Stefano Angioni, Michela Bernassola, Tommaso De Vita, Daniela Anna Iaccarino, Luca Giannoni, Maurizio Rosati
Background: The validation of laser usage during laparoscopic procedures, notably by Camran Nezhat in the late 1980s, has been significant. Lasers offer precision and depth control in tissue vaporization without bleeding. Surgical intervention remains central in managing endometriosis-associated pain and infertility, especially for patients unresponsive to hormonal therapy. Methods: This retrospective
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Concomitant Glenohumeral Pathologies in Patients with Acromioclavicular Joint Dislocations: How Do Acute and Chronic Instabilities Differ? J. Clin. Med. (IF 3.9) Pub Date : 2024-03-17 Philipp Vetter, Manije Massih, Frederik Bellmann, Larissa Eckl, Philipp Moroder, Asimina Lazaridou, Markus Scheibel
Background: Concomitant glenohumeral pathologies may be present in patients with acromioclavicular joint (ACJ) dislocations. This study aims to record and compare the prevalence and treatment of CGP in cases with acute and chronic ACJ dislocations. Methods: This retrospective cross-sectional binational, bicentric study included patients that underwent arthroscopically assisted stabilization for acute
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Cerebroplacental Ratio as a Predictive Factor of Emergency Cesarean Sections for Intrapartum Fetal Compromise: A Systematic Review J. Clin. Med. (IF 3.9) Pub Date : 2024-03-17 Blanca Novillo-Del Álamo, Alicia Martínez-Varea, Elena Satorres-Pérez, Mar Nieto-Tous, Silvia Bello-Martínez de Velasco, María Victoria García-Florenciano, Carmen Padilla-Prieto, Fernando Modrego-Pardo, José Morales-Roselló
Background: This systematic review aimed to clarify the association between the cerebroplacental ratio (CPR) and emergency cesarean sections (CSs) due to intrapartum fetal compromise (IFC). Methods: Datasets of PubMed, ScienceDirect, CENTRAL, Embase, and Google Scholar were searched for studies published up to January 2024 regarding the relationship between the CPR and the rate of CS for IFC, as well
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A Survey to Quantify the Number and Structure of Extracorporeal Membrane Oxygenation Retrieval Programs in the United States J. Clin. Med. (IF 3.9) Pub Date : 2024-03-17 Mircea R. Mihu, Laura V. Swant, Robert S. Schoaps, Caroline Johnson, Aly El Banayosy
(1) Background: Extracorporeal membrane oxygenation (ECMO) represents a potentially lifesaving support for respiratory and/or circulatory failure but its availability is limited to larger medical centers. A well-organized regional ECMO center with remote cannulation and retrieval ability can offer this intervention to patients treated at hospitals without ECMO. Information regarding the number and
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Mitochondrial Metabolism in Major Depressive Disorder: From Early Diagnosis to Emerging Treatment Options J. Clin. Med. (IF 3.9) Pub Date : 2024-03-17 Ane Larrea, Laura Sánchez-Sánchez, Eguzkiñe Diez-Martin, Ane Elexpe, María Torrecilla, Egoitz Astigarraga, Gabriel Barreda-Gómez
Major Depressive Disorder (MDD) is one of the most disabling diseases in the world. MDD is traditionally diagnosed based on a patient’s symptoms, which can lead to misdiagnosis. Although the pathogenic mechanisms of MDD are unknown, several studies have identified mitochondrial dysfunction as a central factor in the onset and progression of MDD. In the context of MDD, alterations in mitochondrial metabolism
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Hallux Valgus Plantar Pressure Distribution before and after a Distal Metatarsal Osteotomy J. Clin. Med. (IF 3.9) Pub Date : 2024-03-17 Antonio Mazzotti, Alberto Arceri, Elena Artioli, Laura Langone, Simone Ottavio Zielli, Beatrice Martini, Francesco Traina, Cesare Faldini, Lorenzo Brognara
Background: Hallux valgus (HV) morphological alterations impact forefoot kinetics. Surgery aims to restore both the morphology and function. Plantar pressure (PP) distribution systems represent an innovative additional tool to evaluate the hallux functional outcome after surgery in order to assess the hallux dorsiflexion, coupled with plantar flexion of the first ray. However, the literature reports
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Early HbA1c Levels as a Predictor of Adverse Obstetric Outcomes: A Systematic Review and Meta-Analysis J. Clin. Med. (IF 3.9) Pub Date : 2024-03-17 Laura Mañé, Humberto Navarro, Juan Pedro-Botet, Juan José Chillarón, Silvia Ballesta, Antonio Payà, Verónica Amador, Juana Antonia Flores-Le Roux, David Benaiges
Background: The objective was to assess the association between early HbA1c levels and pregnancy complications and whether this relationship is affected when HbA1c thresholds are greater than or less than 39 mmol/mol (5.7%). Methods: Electronic searches of the MEDLINE and EMBASE databases up to October 2022 were conducted. We included retrospective and prospective observational studies. The inclusion
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Comparing the Efficacy of Carboplatin plus 5-Fluorouracil, Cisplatin plus 5-Fluorouracil, and Best Supportive Care for Advanced Esophageal Squamous Cell Carcinoma: A Propensity Score Analysis from a Tertiary Hospital in Southern Thailand J. Clin. Med. (IF 3.9) Pub Date : 2024-03-17 Jirapat Wonglhow, Panu Wetwittayakhlang, Patrapim Sunpaweravong, Chirawadee Sathitruangsak, Arunee Dechaphunkul
Background: Although cisplatin plus 5-fluorouracil (5-FU) is the standard first-line treatment for advanced-stage esophageal squamous cell carcinoma (ESCC), carboplatin was substituted for cisplatin in cisplatin-ineligible patients. The efficacy of carboplatin plus 5-FU for advanced-stage ESCC remains unreported. Methods: This retrospective study analyzed first-line treatment—carboplatin plus 5-FU
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The Influence of Arrhythmias and Metabolic Profile on Inpatient Mortality in Patients with Left Ventricular Assist Devices J. Clin. Med. (IF 3.9) Pub Date : 2024-03-17 Daniel Antwi-Amoabeng, Bryce David Beutler, Tokunbo David Gbadebo
Background: In patients with end-stage heart failure, durable Left Ventricular Assist Devices (LVADs) can be used as a bridge to transplant or destination therapy. LVADs have been shown to improve survival for patients with heart failure (HF). HF is associated with electrolyte abnormalities and the development of sustained arrhythmias. However, data on the influence of arrhythmias and electrolyte imbalances
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New Public Health and Sport Medicine Institutions Guidelines of Physical Activity Intensity for Pregnancy—A Scoping Review J. Clin. Med. (IF 3.9) Pub Date : 2024-03-18 Aneta Worska, Ida Laudańska-Krzemińska, Julia Ciążyńska, Beata Jóźwiak, Janusz Maciaszek
Background: Before starting PA, pregnant women should select the appropriate type of training and adjust its components to the development of pregnancy and her capabilities. This review aimed to analyze current recommendations for pregnant women on methods for determining and assessing PA intensity levels and characterize the extent and nature of the information provided to pregnant women in official
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Reports of Gastric Banding and Bowel Obstruction: A Narrative Review of the Literature J. Clin. Med. (IF 3.9) Pub Date : 2024-03-18 Antonio Vitiello, Alessandro Matarese, Giulia Sansone, Emanuela Cappiello, Giovanna Berardi, Pietro Calabrese, Roberto Peltrini, Vincenzo Pilone
The utilization rates of laparoscopic gastric banding (LAGB) declined worldwide from 42.3% in 2008 to 1.8% in 2018. Rates of complications requiring removal may reach 40–50% in the medium to long term. Bowel obstruction is a rare but severe complication that occurs after LAGB. A comprehensive literature search in PubMed was carried out to identify all available case reports of intestinal obstruction
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An Evaluation of Plasma TNF, VEGF-A, and IL-6 Determination as a Risk Marker of Atherosclerotic Vascular Damage in Early-Onset CAD Patients J. Clin. Med. (IF 3.9) Pub Date : 2024-03-18 Marta Bialecka, Michał Rac, Violetta Dziedziejko, Krzysztof Safranow, Dariusz Chlubek, Monika Ewa Rać
Background: The pathogenesis of atherosclerosis is multifactorial and diverse. Pro-inflammatory cytokines are involved in these processes. It is suggested that inflammation may represent a novel and modifiable risk factor for cardiovascular disease. Therefore, this study aimed to gain insight into the relationship between plasma concentrations of TNF, VEGF, IL-6, and radiological parameters of atherosclerosis
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Evaluation of Serum Myostatin Concentration in Chronic Heart Failure with Preserved and Impaired Left Ventricular Ejection Fraction J. Clin. Med. (IF 3.9) Pub Date : 2024-03-18 Jan Bączek, Mirosław Charkiewicz, Agnieszka Kasiukiewicz, Anna Maria Witkowska, Łukasz Magnuszewski, Marta Bączek, Zyta Beata Wojszel
Background: Chronic heart failure (CHF) is a complex clinical syndrome associated with muscle wasting, which can progress to cardiac cachexia. Myostatin, a negative regulator of muscle growth, has been implicated in the pathophysiology of muscle wasting in CHF patients and suggested as a potential biomarker. The objective of this study was to investigate serum myostatin concentration in patients with
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RETRACTED: De Vecchis et al. Vasopressin Receptor Antagonists for the Correction of Hyponatremia in Chronic Heart Failure: An Underutilized Therapeutic Option in Current Clinical Practice? J. Clin. Med. 2016, 5, 86 J. Clin. Med. (IF 3.9) Pub Date : 2024-03-18 Renato De Vecchis, Claudio Cantatrione, Damiana Mazzei, Cesare Baldi
The Journal of Clinical Medicine retracts the article “Vasopressin Receptor Antagonists for the Correction of Hyponatremia in Chronic Heart Failure: An Underutilized Therapeutic Option in Current Clinical Practice [...]
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Comparison of Cylindrical and Tapered Stem Designs for Femoral Revision Hip Arthroplasty J. Clin. Med. (IF 3.9) Pub Date : 2024-03-18 José María Hernández-Mateo, Javier Orozco-Martínez, José Antonio Matas-Díaz, Francisco Javier Vaquero, Pablo Sanz-Ruiz
Background: Cylindrical fully-coated cobalt-chromium stems (CCS) have been widely used in femoral revisions. However, monoblock fluted conical tapered stems (FCTS) are growing in popularity. The present study seeks to determine whether there are any long-term differences between the two designs. Material and methods: A retrospective study of 38 CCS versus 40 FCTS was carried out. Demographic data,
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Clinical Utility of Genetic Testing with Geographical Locations in ADPKD: Describing New Variants J. Clin. Med. (IF 3.9) Pub Date : 2024-03-18 Carmen García Rabaneda, María Luz Bellido Díaz, Ana Isabel Morales García, Antonio Miguel Poyatos Andújar, Juan Bravo Soto, Anita Dayaldasani Khialani, Margarita Martínez Atienza, Rafael Jose Esteban de la Rosa
Background: Our study aims to comment on all ADPKD variants identified in our health area and explain how they are distributed geographically, to identify new variants, and relate the more frequent variants with their renal phenotype in terms of kidney survival. Materials and Methods: We identified patients suffering from ADPKD in a specialized consultation unit; genealogical trees were constructed
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A RAND/UCLA-Modified VASStudy on Telemedicine, Telehealth, and Virtual Care in Daily Clinical Practice of Vascular Medicine J. Clin. Med. (IF 3.9) Pub Date : 2024-03-18 Sergio Pillon, Georgia Gomatou, Evangelos Dimakakos, Agata Stanek, Zsolt Pecsvarady, Matija Kozak, Jean-Claude Wautrecht, Katalin Farkas, Gerit-Holger Schernthaner, Mariella Catalano, Aleš Blinc, Grigorios Gerotziafas, Pavel Poredoš, Sergio De Marchi, Michael E. Gschwandtner, Endre Kolossváry, Muriel Sprynger, Bahar Fazeli, Aaron Liew, Peter Marschang, Andrzej Szuba, Dusan Suput, Michael Edmonds, Chris
Telemedicine is increasingly used in several fields of healthcare, including vascular medicine. This study aimed to investigate the views of experts and propose clinical practice recommendations on the possible applications of telemedicine in vascular medicine. Methods: A clinical guidance group proposed a set of 67 clinical practice recommendations based on the synthesis of current evidence and expert
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The Moderating Role of Anxiety and Depressive Symptoms in Protective Effects of Health Behaviors among Clients Using Mental Health Services J. Clin. Med. (IF 3.9) Pub Date : 2024-03-18 Yusen Zhai, Mahmood Almaawali, Xue Du
College-student clients using mental health services contend with increased anxiety and depressive symptoms, and their vulnerability to infectious respiratory diseases and severe clinical outcomes rises. To mitigate severe outcomes, health behaviors serve as essential protective tools to reduce the risk of infectious diseases, including COVID-19. Considering the escalating prevalence of anxiety and
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The Efficacy and Effectiveness of the Biological Treatment of Pruritus in the Course of Atopic Dermatitis J. Clin. Med. (IF 3.9) Pub Date : 2024-03-18 Agnieszka Marta Hołdrowicz, Anna Woźniacka
Atopic dermatitis is a heterogenous inflammatory disease with high variety in terms of clinical symptoms and etiopathogenesis, occurring both in pediatric and adult populations. The clinical manifestation of atopic dermatitis varies depending on the age of patients, but all age groups share certain common features, such as a chronic and recurrent course of disease, pruritus, and a co-occurrence of
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Public Attitude towards Implementing DNAR and a Stance on Pediatric DNAR in Poland—A Prospective Survey Study J. Clin. Med. (IF 3.9) Pub Date : 2024-03-18 Dariusz Timler, Joanna Kempa, Remigiusz Kozłowski, Robert Stolarek, Wojciech Timler
Background: Do not attempt resuscitation (DNAR) is a document signed by a patient, which states that they do not want to be resuscitated. In Poland, DNAR is not regulated by law. We aimed to assess people’s perceptions on DNAR and pediatric DNAR in Poland. Methods: An anonymous survey was distributed via the snowball sampling method in different voivodeships in Poland in the years 2014–2018. The survey
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Influence of Narrow Titanium Dental Implant Diameter on Fatigue Behavior: A Comparison between Unitary and Splinted Implants J. Clin. Med. (IF 3.9) Pub Date : 2024-03-13 Rodrigo González Terrats, María Bonnín Liñares, Miquel Punset, Meritxell Molmeneu, José Nart Molina, Vanessa Ruíz Magaz, Matteo Albertini, José María Manero, Javier Gil Mur
Background: Scientific literature lacks strong support for using narrow diameter implants (NDI) in high masticatory force areas, especially in molars. Implant splinting in cases of multiple missing teeth reduces lateral forces, improves force distribution, and minimizes stress on implants. However, no studies have evaluated the fatigue load resistance of unitary or splinted implants. Methods: This
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Functional and Rehabilitative Outcomes of Patients Affected by Bone Cancer of the Upper Limb Treated with MUTARS Prosthesis: A Narrative Review J. Clin. Med. (IF 3.9) Pub Date : 2024-03-13 Sefora Codazza, Paola Emilia Ferrara, Adelaide Aprovitola, Mariantonietta Ariani, Fabiana La Cagnina, Daniele Coraci, Giorgio Ferriero, Gianpaolo Ronconi
Megaprostheses are well-known, reliable, and effective reconstruction prostheses used in oncologic surgery for limb salvage in patients affected by primary or metastatic bone tumors. Rehabilitation plays a major role after MUTARS replacement, with the aim of improving function after surgery and maintaining the highest possible quality of life. Only a few studies have been published about the use of
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Changes of Sublingual Microcirculation during the Treatment of Severe Diabetic Ketoacidosis J. Clin. Med. (IF 3.9) Pub Date : 2024-03-14 Vlasta Krausova, David Neumann, Jaroslav Skvor, Pavel Dostal
Introduction: Diabetic ketoacidosis (DKA) is associated with volume depletion and hemodynamic alterations. Changes in systemic microcirculation during DKA have not been described so far. Methods: In this case report, we describe the evolution of sublingual microcirculatory changes, monitored using sidestream dark field (SDF) imaging during the treatment of severe diabetic ketoacidosis in a 13-year-old
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Psychometric Properties of the Gastrointestinal Symptom Severity Scale in a Sample of Adolescents and Young Adults J. Clin. Med. (IF 3.9) Pub Date : 2024-03-14 Agustín Ernesto Martínez-González, Néstor Montoro-Pérez, Agustín Wallace, Susana Pérez-Sánchez, José A. Piqueras, Lidia Infante-Cañete, Silvia Hidalgo-Berutich, Tíscar Rodríguez-Jiménez, Pedro Andreo-Martínez
Background: Functional gastrointestinal disorders (FGIDs) are a set of chronic or recurrent gastrointestinal symptoms (GS) with great psychobiological complexity. The appearance of FGIDs harms quality of life and drains medical resources. Methods: Psychometric properties of the Gastrointestinal Symptom Severity Scale (GSSS) based on Rome IV criteria were examined in a sample of 1247 individuals with
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Clinical Characteristics and Incidence of Hemorrhagic Complications in Patients Taking Factor Xa Inhibitors in Spain: A Long-Term Observational Study J. Clin. Med. (IF 3.9) Pub Date : 2024-03-14 Carlos Escobar, Beatriz Palacios, Miriam Villarreal, Martín Gutiérrez, Margarita Capel, Ignacio Hernández, María García, Laura Lledó, Juan F. Arenillas
Objective. To analyze the clinical characteristics of patients taking Factor Xa inhibitors (FXai), either direct FXai or enoxaparin (only in active cancer patients), and to estimate the incidence of and risk factors for major bleeding during FXai use. Methods. A retrospective cohort study, which included secondary data from computerized health records of primary care centers and hospitals in seven
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Intraoperative Hemodynamic Instability and Higher ASA Classification Increase the Risk of Developing Non-Surgical Complications following Orthopedic Surgeries J. Clin. Med. (IF 3.9) Pub Date : 2024-03-15 Ting-Jui Hsu, Jen-Yu Chen, Yu-Ling Wu, Yu-Han Lo, Chien-Jen Hsu
(1) Background: Either pre-operative physical status or unstable hemodynamic changes has been reported to play a potential role in causing vital organ dysfunction. Therefore, we intended to investigate the impact of the American Society of Anesthesiologist (ASA) classification and intraoperative hemodynamic instability on non-surgical complications following orthopedic surgery. (2) Methods: We collected
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The Effect of the Direction of Primary Lateral Spinal Curvature on Postural Stability in Children with Scoliosis J. Clin. Med. (IF 3.9) Pub Date : 2024-03-15 Andrzej Siwiec, Małgorzata Domagalska-Szopa, Ilona Kwiecień-Czerwieniec, Andrzej Szopa
Background: The purpose of the present study was to determine the impact of the direction and magnitude of primary lateral spinal curvature in children with scoliosis. Methods: Ninety-six children diagnosed with scoliosis were included in the study group, and fifty healthy peers were included in the control group. Posturographic measurements of body weight distribution and posturometric tests with
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Prognostic Factors Affecting the Outcome of Surgical Root Canal Treatment—A Retrospective Cone-Beam Computed Tomography Cohort Study J. Clin. Med. (IF 3.9) Pub Date : 2024-03-15 Salma AlKhuwaitir, Shanon Patel, Abdulaziz Bakhsh, John Spencer Rhodes, Luis Miguel Ferrández, Francesco Mannocci
Aim: To assess the association between demographic and clinical variables and the outcome of root-end surgery using digital periapical radiographs (PA) and cone-beam computed tomography (CBCT). Methodology: One hundred and fifty teeth that received endodontic microsurgery were clinically and radiographically examined (PA and CBCT scans) after 1 and 2 years. Two calibrated endodontists evaluated the
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Pregnancy in Glomerular Disease: From Risk Identification to Counseling and Management J. Clin. Med. (IF 3.9) Pub Date : 2024-03-15 Veronica Maressa, Elisa Longhitano, Chiara Casuscelli, Silvia Di Carlo, Luigi Peritore, Domenico Santoro
Background: Pregnancy involves complex hemodynamic and immune adaptations to support the developing fetus. The kidney assumes a pivotal role in orchestrating these mechanisms. However, renal disease poses a potential risk for adverse maternal–fetal outcomes. While kidney function, hypertension, and proteinuria are recognized as key influencers of risk, the mere presence of glomerular disease, independent
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Cardiac Sarcoidosis—Diagnostic and Therapeutic Challenges J. Clin. Med. (IF 3.9) Pub Date : 2024-03-15 Dennis Korthals, Michael Bietenbeck, Hilke Könemann, Florian Doldi, David Ventura, Michael Schäfers, Michael Mohr, Julian Wolfes, Felix Wegner, Ali Yilmaz, Lars Eckardt
Sarcoidosis is a multisystem disorder of unknown etiology. The leading hypothesis involves an antigen-triggered dysregulated T-cell-driven immunologic response leading to non-necrotic granulomas. In cardiac sarcoidosis (CS), the inflammatory response can lead to fibrosis, culminating in clinical manifestations such as atrioventricular block and ventricular arrhythmias. Cardiac manifestations frequently
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The Complete Anatomy of the Anterior Ethmoidal Artery: A Meta-Analysis with Implications for Sinus and Skull Base Surgery J. Clin. Med. (IF 3.9) Pub Date : 2024-03-15 Elżbieta Szczepanek, Julia Toppich, Patryk Ostrowski, Michał Bonczar, Ameen Nasser, Martyna Dziedzic, Jerzy Walocha, Mateusz Koziej
Background: The anatomical characteristics of the anterior ethmoidal artery (AEA) exhibit a high degree of variability, especially regarding its topography. Methods: PubMed, Scopus, Embase, Web of Science, Cochrane Library, and Google Scholar were searched to identify all studies that included information regarding the morphometric and topographical characteristics of the AEA. Results: Ultimately,
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The Longitudinal Association between Multiple Frailty Criteria and Depressive Symptomatology Five Years Later in Older Adults: A Decision Tree Modelling Approach J. Clin. Med. (IF 3.9) Pub Date : 2024-03-15 Marcelo de Maio Nascimento, Adilson Marques, Élvio R. Gouveia, Priscila Marconcin, Miguel Peralta, Andreas Ihle
Background: To examine the longitudinal association between frailty criteria and depression (DEP) in a large sample of older Europeans using decision tree models, and to examine complex relationships between frailty criteria and DEP symptomatology. Methods: Data come from waves six and eight of the Population Survey of Health, Ageing and Retirement in Europe. DEP was assessed using the EURO-D scale
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The Sum of the Leg Length Discrepancy and the Difference in Global Femoral Offset Is Equal to That of the Contralateral Intact Side and Improves Postoperative Outcomes after Total Hip Arthroplasty: A Three-Dimensional Analysis J. Clin. Med. (IF 3.9) Pub Date : 2024-03-15 Norio Imai, Yuki Hirano, Yuki Endo, Yoji Horigome, Hayato Suzuki, Hiroyuki Kawashima
Background/Objectives: Global femoral offset (GFO) and leg length discrepancy (LLD) affect outcomes after total hip arthroplasty (THA). Moreover, the sum of the difference in GFO between the THA and non-surgical sides and LLD (SGL) reportedly affects the outcomes in a two-dimensional evaluation. We examined the association of the GFO, LLD, and SGL with the Harris Hip Score (HHS) using a three-dimensional
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Comparison of Long-Term Postoperative Outcomes of the Subtypes of Chronic Rhinosinusitis with Nasal Polyps J. Clin. Med. (IF 3.9) Pub Date : 2024-03-15 Sang-Min Lee, Shin-Hyuk Yoo, Ji-Hun Mo
(1) Background: Chronic rhinosinusitis with nasal polyps (CRSwNP) is a chronic inflammatory condition that significantly impacts the health-related quality of life (HRQOL) of patients. This study aims to investigate the disparities in preoperative examination findings, postoperative HRQOL, and disease control status based on CRSwNP subtypes. (2) Methods: A retrospective analysis was conducted on 202
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The Burden of Pediatric Atopic Dermatitis: Quality of Life of Patients and Their Families J. Clin. Med. (IF 3.9) Pub Date : 2024-03-15 Inga Kisieliene, Antanas Mainelis, Odilija Rudzeviciene, Matilda Bylaite-Bucinskiene, Andreas Wollenberg
(1) Background: Atopic dermatitis (AD) is one of the most common inflammatory skin conditions, thus having a significant impact on the quality of life (QoL) of patients and their families. We performed a survey to gather more data to help describe the burden of AD in Lithuania and to help expand the treatment plan to this important aspect of the disease. (2) Methods: A cross-sectional study was conducted
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Time-Lapse Incubation for Embryo Culture-Morphokinetics and Environmental Stability May Not Be Enough: Results from a Pilot Randomized Controlled Trial J. Clin. Med. (IF 3.9) Pub Date : 2024-03-15 Gilat C. Sacks, Henny Mozes, Ruth Ronn, Talia Elder-Geva, Oshrat Schonberger, Ido Ben-Ami, Naama Srebnik
Background: Does the Time-lapse Incubator (TLI) add value to reproductive outcomes when its two components, undisturbed culturing and morphokinetic embryo grading, are separated. Methods: A prospective pilot, randomized, controlled, double-blinded, single-center study was conducted during the years 2016–2020. In total, 102 patients were randomized into three groups: (1) conventional incubation with
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Fatigue Item Response among Hemoglobin-Normalized Patients with Paroxysmal Nocturnal Hemoglobinuria: PEGASUS Trial Results at 16 and 48 Weeks J. Clin. Med. (IF 3.9) Pub Date : 2024-03-15 Carolyn E. Schwartz, Katrina Borowiec, Jinny Min, Jesse Fishman
Background. A common symptom of paroxysmal nocturnal hemoglobinuria (PNH) is fatigue, which in some patients can be severe. Eculizumab (Ecu) has proven efficacy in controlling intravascular hemolysis, but commonly results in persistent anemia and fatigue. Pegcetacoplan’s (Peg) efficacy was documented in the PEGASUS phase III clinical trial, showing improved hemoglobin (Hb) and patient-reported fatigue
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Effect of Sex, Age, and Cardiovascular Risk Factors on Aortoiliac Segment Geometry J. Clin. Med. (IF 3.9) Pub Date : 2024-03-15 Ádám Szőnyi, György Balázs, Balázs Bence Nyárády, Márton Philippovich, Tamás Horváth, Edit Dósa
Background: To investigate the geometry of the aortoiliac (AI) segment and its correlation with sex, age, and cardiovascular (CV) risk factors. Methods: Abdominal and pelvic CTA/MRA scans of 204 subjects (120 males; median age: 53 [IQR, 27–75] years) without AI steno-occlusive disease or scoliosis were retrospectively analyzed. The participants were enrolled consecutively, ensuring the representation
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Language Lateralization by Passive Auditory fMRI in Presurgical Assessment for Temporal Lobe Epilepsy: A Single-Center Retrospective Study J. Clin. Med. (IF 3.9) Pub Date : 2024-03-15 Yoji Okahara, Kyoko Aoyagi, Hiroto Iwasa, Yoshinori Higuchi
Background: In temporal lobe epilepsy (TLE), estimating the potential risk of language dysfunction before surgery is a necessary procedure. Functional MRI (fMRI) is considered the most useful to determine language lateralization noninvasively. However, there are no standardized language fMRI protocols, and several issues remain unresolved. In particular, the language tasks normally used are predominantly
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Early Treatment of Acute Stage 0/1 Diabetic Charcot Foot Can Avoid Major Amputations at One Year J. Clin. Med. (IF 3.9) Pub Date : 2024-03-13 Cristina Bittante, Valerio Cerasari, Ermanno Bellizzi, Raju Ahluwalia, Michela Di Venanzio, Laura Giurato, Aikaterini Andreadi, Alfonso Bellia, Luigi Uccioli, Davide Lauro, Marco Meloni
Background: If unrecognized, Charcot neuro-osteoarthropathy (CNO) can be a devastating complication of diabetes. Methods: The aim of this retrospective study was to evaluate the outcomes in a cohort of diabetic patients diagnosed with active CNO managed in a tertiary level diabetic foot clinic (DFC). We included consecutive patients with active CNO, stage 0–1, according to the Eichenholtz–Shibata classification
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Drug Related Problems among Older Inpatients at a Tertiary Care Setting J. Clin. Med. (IF 3.9) Pub Date : 2024-03-13 Porrawee Pramotesiri, Krongtong Putthipokin, Sirasa Ruangritchankul
Background: Older persons are more likely to have multiple chronic diseases, leading to the simultaneous use of many medications. This situation results in increased drug-related problems (DRPs), which are the causes of adverse health outcomes. Therefore, we aimed to evaluate the prevalence of and associated risk factors for exposure to >1 criterion of DRPs among older adults admitted to a tertiary
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Nephrectomy with Autotransplantation—A Key Treasure J. Clin. Med. (IF 3.9) Pub Date : 2024-03-13 Sofia Mesquita, Miguel Marques-Monteiro, Mariana Madanelo, Maria Alexandra Rocha, Nuno Vinagre, Avelino Fraga, Vítor Cavadas, Rui Machado, Miguel Silva-Ramos
Background: Nephrectomy with autotransplantation (NAT) has been performed as an alternative treatment for complex renovascular lesions, intricate ureteral strictures and nephron-sparing surgery in complex renal tumors. Methods: A retrospective observational study was conducted including patients who underwent a NAT from January 2010 to September 2023. Data collected included surgery indications, surgical
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Neurocutaneous Diseases: Diagnosis, Management, and Treatment J. Clin. Med. (IF 3.9) Pub Date : 2024-03-13 Ivelina Kioutchoukova, Devon Foster, Rajvi Thakkar, Christopher Ciesla, Jake Salvatore Cabassa, Jacob Strouse, Hayley Kurz, Brandon Lucke-Wold
Neurocutaneous disorders, also known as phakomatoses, are congenital and acquired syndromes resulting in simultaneous neurologic and cutaneous involvement. In several of these conditions, the genetic phenomenon is understood, providing a pivotal role in the development of therapeutic options. This review encompasses the discussion of the genetic and clinical involvement of neurocutaneous disorders
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Robotic Lobectomy Learning Curve Has Better Clinical Outcomes than Videothoracoscopic Lobectomy J. Clin. Med. (IF 3.9) Pub Date : 2024-03-14 Pablo Luis Paglialunga, Laureano Molins, Rudith Guzmán, Angela Guirao, Irene Bello, Anna Ureña, Leandro Grando, Nestor Quiroga, Xavier Michavila, Marc Boada
Introduction: The robotic-assisted (RATS) lobectomy learning curve is usually measured compared to an established videothoracoscopic (VATS) surgery program. The objective of our study is to compare the learning curves of both techniques. Methods: We performed an intention-to-treat analysis comparing the RATS vs. VATS lobectomies. Surgical time, conversions, complications, number of lymph nodes (LNs)
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Do Patient Sex and Age Affect Hemiepiphysiodesis Outcomes? J. Clin. Med. (IF 3.9) Pub Date : 2024-03-14 Piotr Morasiewicz, Paweł Leyko, Łukasz Tomczyk, Krystian Kazubski
(1) Background: The purpose of this study was to assess the effects of sex and age on the outcomes of hemiepiphysiodesis performed for genu valgum and varum deformity correction. (2) Methods: We analyzed patients who had undergone O-Plate hemiepiphysiodesis due to genu valgum or varum in the period of 2020–2023. The study group comprised 22 females and 20 males aged between 3 and 14 years at the time
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Radiographic Detection Rate of Distal Surface Caries in the Mandibular Second Molar in Populations with Different Third Molar Management Strategies: A Multicenter Study J. Clin. Med. (IF 3.9) Pub Date : 2024-03-14 Verena Toedtling, Elena-Cristina Marcov, Narcis Marcov, Dana Bodnar, Mina W. A. Hayawi, Tim Forouzanfar, Henk S. Brand
Background: Distal surface caries (DSC) has been associated with partially erupted impacted third molars. The purpose of this study was to compare the rates of DSC between populations that had undergone different third molar management strategies. Methods: Radiographs that had been taken during routine examinations of 1012, 251 and 250 patients in Manchester, Bucharest and Amsterdam, respectively,