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Dysregulated N6-methyladenosine modification in peripheral immune cells contributes to the pathogenesis of amyotrophic lateral sclerosis Front. Med. (IF 8.1) Pub Date : 2024-03-16 Di He, Xunzhe Yang, Liyang Liu, Dongchao Shen, Qing Liu, Mingsheng Liu, Xue Zhang, Liying Cui
Amyotrophic lateral sclerosis (ALS) is a progressive neurogenerative disorder with uncertain origins. Emerging evidence implicates N6-methyladenosine (m6A) modification in ALS pathogenesis. Methylated RNA immunoprecipitation sequencing (MeRIP-seq) and liquid chromatography–mass spectrometry were utilized for m6A profiling in peripheral immune cells and serum proteome analysis, respectively, in patients
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A distinct “repair” role of regulatory T cells in fracture healing Front. Med. (IF 8.1) Pub Date : 2024-03-16 Tingting Wu, Lulu Wang, Chen Jian, Zhenhe Zhang, Ruiyin Zeng, Bobin Mi, Guohui Liu, Yu Zhang, Chen Shi
Regulatory T cells (Tregs) suppress immune responses and inflammation. Here, we described the distinct nonimmunological role of Tregs in fracture healing. The recruitment from the circulation pool, peripheral induction, and local expansion rapidly enriched Tregs in the injured bone. The Tregs in the injured bone displayed superiority in direct osteogenesis over Tregs from lymphoid organs. Punctual
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Arginine methylation of ALKBH5 by PRMT6 promotes breast tumorigenesis via LDHA-mediated glycolysis Front. Med. (IF 8.1) Pub Date : 2024-03-11
Abstract ALKBH5 is a master regulator of N6-methyladenosine (m6A) modification, which plays a crucial role in many biological processes. Here, we show that ALKBH5 is required for breast tumor growth. Interestingly, PRMT6 directly methylates ALKBH5 at R283, which subsequently promotes breast tumor growth. Furthermore, arginine methylation of ALKBH5 by PRMT6 increases LDHA RNA stability via m6A demethylation
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Immune landscape and response to oncolytic virus-based immunotherapy Front. Med. (IF 8.1) Pub Date : 2024-03-08 Chaolong Lin, Wenzhong Teng, Yang Tian, Shaopeng Li, Ningshao Xia, Chenghao Huang
Oncolytic virus (OV)-based immunotherapy has emerged as a promising strategy for cancer treatment, offering a unique potential to selectively target malignant cells while sparing normal tissues. However, the immunosuppressive nature of tumor microenvironment (TME) poses a substantial hurdle to the development of OVs as effective immunotherapeutic agents, as it restricts the activation and recruitment
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Gut microbiota-dependent phenylacetylglutamine in cardiovascular disease: current knowledge and new insights Front. Med. (IF 8.1) Pub Date : 2024-03-01 Yaonan Song, Haoran Wei, Zhitong Zhou, Huiqing Wang, Weijian Hang, Junfang Wu, Dao Wen Wang
Phenylacetylglutamine (PAGln) is an amino acid derivate that comes from the amino acid phenylalanine. There are increasing studies showing that the level of PAGln is associated with the risk of different cardiovascular diseases. In this review, we discussed the metabolic pathway of PAGln production and the quantitative measurement methods of PAGln. We summarized the epidemiological evidence to show
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EBV-associated lymphoproliferative disease post-CAR-T cell therapy Front. Med. (IF 8.1) Pub Date : 2024-02-08 Shiyuan Zhang, Xiaoxi Zhou, Shangkun Zhang, Na Wang, Tongcun Zhang, Donghua Zhang, Qilin Ao, Yang Cao, Liang Huang
Epstein–Barr virus (EBV)-associated lymphoproliferative diseases (EBV-LPDs) are common complications that occur after solid organ transplantation or allogeneic hematopoietic stem-cell transplantation (HSCT). However, their occurrence and treatment post-chimeric antigen receptor-modified T (CAR-T) cell therapy has not been reported. Two patients had been diagnosed with EBV-positive aggressive B-cell
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Insights into optimizing exosome therapies for acute skin wound healing and other tissue repair Front. Med. (IF 8.1) Pub Date : 2024-01-13 Tianjing Sun, Mo Li, Qi Liu, Anyong Yu, Kun Cheng, Jianxing Ma, Sean Murphy, Patrick Michael McNutt, Yuanyuan Zhang
Exosome therapy holds great promise as a novel approach to improve acute skin wound healing. This review provides a comprehensive overview of the current understanding of exosome biology and its potential applications in acute skin wound healing and beyond. Exosomes, small extracellular vesicles secreted by various stem cells, have emerged as potent mediators of intercellular communication and tissue
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Epidemiology, pathogenesis, and management of Coronavirus disease 2019-associated stroke Front. Med. (IF 8.1) Pub Date : 2024-01-02 Lu Liu, Chenxia Zhou, Huimin Jiang, Huimin Wei, Yifan Zhou, Chen Zhou, Xunming Ji
The Coronavirus disease 2019 (COVID-19) epidemic has triggered a huge impact on healthcare, socioeconomics, and other aspects of the world over the past three years. An increasing number of studies have identified a complex relationship between COVID-19 and stroke, although active measures are being implemented to prevent disease transmission. Severe COVID-19 may be associated with an increased risk
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Small-molecule anti-COVID-19 drugs and a focus on China’s homegrown mindeudesivir (VV116) Front. Med. (IF 8.1) Pub Date : 2024-01-02 Qiuyu Cao, Yi Ding, Yu Xu, Mian Li, Ruizhi Zheng, Zhujun Cao, Weiqing Wang, Yufang Bi, Guang Ning, Yiping Xu, Ren Zhao
The coronavirus disease 2019 (COVID-19) pandemic has stimulated tremendous efforts to develop therapeutic agents that target severe acute respiratory syndrome coronavirus 2 to control viral infection. So far, a few small-molecule antiviral drugs, including nirmatrelvir–ritonavir (Paxlovid), remdesivir, and molnupiravir have been marketed for the treatment of COVID-19. Nirmatrelvir–ritonavir has been
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Unraveling the complex roles of macrophages in obese adipose tissue: an overview Front. Med. (IF 8.1) Pub Date : 2024-01-02 Chang Peng, Jun Chen, Rui Wu, Haowen Jiang, Jia Li
Macrophages, a heterogeneous population of innate immune cells, exhibit remarkable plasticity and play pivotal roles in coordinating immune responses and maintaining tissue homeostasis within the context of metabolic diseases. The activation of inflammatory macrophages in obese adipose tissue leads to detrimental effects, inducing insulin resistance through increased inflammation, impaired thermogenesis
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Cytokine storm and translating IL-6 biology into effective treatments for COVID-19 Front. Med. (IF 8.1) Pub Date : 2023-12-29 Tiantian Li, Dongsheng Wang, Haiming Wei, Xiaoling Xu
As of May 3, 2023, the Coronavirus disease 2019 (COVID-19) pandemic has resulted in more than 760 million confirmed cases and over 6.9 million deaths. Several patients have developed pneumonia, which can deteriorate into acute respiratory distress syndrome. The primary etiology may be attributed to cytokine storm, which is triggered by the excessive release of proinflammatory cytokines and subsequently
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Decitabine induces IRF7-mediated immune responses in p53-mutated triple-negative breast cancer: a clinical and translational study Front. Med. (IF 8.1) Pub Date : 2023-12-29
Abstract p53 is mutated in half of cancer cases. However, no p53-targeting drugs have been approved. Here, we reposition decitabine for triple-negative breast cancer (TNBC), a subtype with frequent p53 mutations and extremely poor prognosis. In a retrospective study on tissue microarrays with 132 TNBC cases, DNMT1 overexpression was associated with p53 mutations (P = 0.037) and poor overall survival
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Multi-omics joint analysis revealed the metabolic profile of retroperitoneal liposarcoma Front. Med. (IF 8.1) Pub Date : 2023-12-29 Fu’an Xie, Yujia Niu, Lanlan Lian, Yue Wang, Aobo Zhuang, Guangting Yan, Yantao Ren, Xiaobing Chen, Mengmeng Xiao, Xi Li, Zhe Xi, Gen Zhang, Dongmei Qin, Kunrong Yang, Zhigang Zheng, Quan Zhang, Xiaogang Xia, Peng Li, Lingwei Gu, Ting Wu, Chenghua Luo, Shu-Hai Lin, Wengang Li
Retroperitoneal liposarcoma (RLPS) is the main subtype of retroperitoneal soft sarcoma (RSTS) and has a poor prognosis and few treatment options, except for surgery. The proteomic and metabolic profiles of RLPS have remained unclear. The aim of our study was to reveal the metabolic profile of RLPS. Here, we performed proteomic analysis (n = 10), metabolomic analysis (n = 51), and lipidomic analysis
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Practice and principle of traditional Chinese medicine for the prevention and treatment of COVID-19 Front. Med. (IF 8.1) Pub Date : 2023-12-29 Linhua Zhao, Chuanxi Tian, Yingying Yang, Huifang Guan, Yu Wei, Yuxin Zhang, Xiaomin Kang, Ling Zhou, Qingwei Li, Jing Ma, Li Wan, Yujiao Zheng, Xiaolin Tong
Traditional Chinese medicine (TCM) has played an important role in the prevention and treatment of Coronavirus disease 2019 (COVID-19) epidemic in China. The integration of Chinese and Western medicine is an important feature of Chinese COVID-19 prevention and treatment. According to a series of evidence-based studies, TCM can reduce the infection rate of severe acute respiratory syndrome coronavirus
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Pathogen evolution, prevention/control strategy and clinical features of COVID-19: experiences from China Front. Med. (IF 8.1) Pub Date : 2023-12-29
Abstract Severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) was reported at the end of 2019 as a worldwide health concern causing a pandemic of unusual viral pneumonia and many other organ damages, which was defined by the World Health Organization as coronavirus disease 2019 (COVID-19). The pandemic is considered a significant threat to global public health till now. In this review, we have
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Improving the prognosis of pancreatic cancer: insights from epidemiology, genomic alterations, and therapeutic challenges Front. Med. (IF 8.1) Pub Date : 2023-12-27 Zhichen Jiang, Xiaohao Zheng, Min Li, Mingyang Liu
Pancreatic cancer, notorious for its late diagnosis and aggressive progression, poses a substantial challenge owing to scarce treatment alternatives. This review endeavors to furnish a holistic insight into pancreatic cancer, encompassing its epidemiology, genomic characterization, risk factors, diagnosis, therapeutic strategies, and treatment resistance mechanisms. We delve into identifying risk factors
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Effects and mechanisms of acupuncture on women related health Front. Med. (IF 8.1) Pub Date : 2023-12-27 Huichao Qin, Jiaxing Feng, Xiaoke Wu
Globally, public health interventions have resulted in a 30-year increase in women’s life expectancy. However, women’s health has not increased when socioeconomic status is ignored. Women’s health has become a major public health concern, for those women from developing countries are still struggling with infectious and labor-related diseases, and their counterparts in developed countries are suffering
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Cross-sectional network analysis of plasma proteins/metabolites correlated with pathogenesis and therapeutic response in acute promyelocytic leukemia Front. Med. (IF 8.1) Pub Date : 2023-12-27 Niu Qiao, Yizhu Lyu, Feng Liu, Yuliang Zhang, Xiaolin Ma, Xiaojing Lin, Junyu Wang, Yinyin Xie, Ruihong Zhang, Jing Qiao, Hongming Zhu, Li Chen, Hai Fang, Tong Yin, Zhu Chen, Qiang Tian, Saijuan Chen
The treatment of PML/RARA+ acute promyelocytic leukemia (APL) with all-trans-retinoic acid and arsenic trioxide (ATRA/ATO) has been recognized as a model for translational medicine research. Though an altered microenvironment is a general cancer hallmark, how APL blasts shape their plasma composition is poorly understood. Here, we reported a cross-sectional correlation network to interpret multilayered
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Innovation-driven trend shaping COVID-19 vaccine development in China Front. Med. (IF 8.1) Pub Date : 2023-12-16 Yuntao Zhang, Yuxiu Zhao, Hongyang Liang, Ying Xu, Chuge Zhou, Yuzhu Yao, Hui Wang, Xiaoming Yang
Confronted with the Coronavirus disease 2019 (COVID-19) pandemic, China has become an asset in tackling the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission and mutation, with several innovative platforms, which provides various technical means in this persisting combat. Derived from collaborated researches, vaccines based on the spike protein of SARS-CoV-2 or inactivated whole
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Associations of sleeping patterns and isotemporal substitution of other behavior with the prevalence of CKD in Chinese adults Front. Med. (IF 8.1) Pub Date : 2023-12-05 Yi Ding, Xiaoli Xu, Zhuojun Xin, Qiuyu Cao, Jiaojiao Huang, Xianglin Wu, Yanan Huo, Qin Wan, Yingfen Qin, Ruying Hu, Lixin Shi, Qing Su, Xuefeng Yu, Li Yan, Guijun Qin, Xulei Tang, Gang Chen, Min Xu, Tiange Wang, Zhiyun Zhao, Zhengnan Gao, Guixia Wang, Feixia Shen, Zuojie Luo, Li Chen, Qiang Li, Zhen Ye, Yinfei Zhang, Chao Liu, Youmin Wang, Tao Yang, Huacong Deng, Lulu Chen, Tianshu Zeng, Jiajun Zhao
Studies have found a U-shaped relationship between sleep duration and chronic kidney disease (CKD) risk, but limited research evaluated the association of reallocating excessive sleep to other behavior with CKD. We included 104 538 participants from the nationwide cohort of the Risk Evaluation of Cancers in Chinese Diabetic Individuals: A Longitudinal Study, with self-reported time of daily-life behavior
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Passive antibody therapy in emerging infectious diseases Front. Med. (IF 8.1) Pub Date : 2023-12-02 Xiaoming Yang
The epidemic of corona virus disease 2019 (COVID-19) caused by severe acute respiratory syndrome Coronavirus 2 and its variants of concern (VOCs) has been ongoing for over 3 years. Antibody therapies encompassing convalescent plasma, hyperimmunoglobulin, and neutralizing monoclonal antibodies (mAbs) applied in passive immunotherapy have yielded positive outcomes and played a crucial role in the early
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Association between ICU quality and in-hospital mortality of V-V ECMO-supported patients—the ECMO quality improvement action (EQIA) study: a national cohort study in China from 2017 to 2019 Front. Med. (IF 8.1) Pub Date : 2023-11-22 Wei Cheng, Jieqing Chen, Xudong Ma, Jialu Sun, Sifa Gao, Ye Wang, Longxiang Su, Lu Wang, Wei Du, Huaiwu He, Yujie Chen, Zunzhu Li, Qi Li, Jianhua Sun, Hongbo Luo, Jinbang Liu, Guangliang Shan, Bing Du, Yanhong Guo, Dawei Liu, Chang Yin, Xiang Zhou
This cohort study was performed to explore the influence of intensive care unit (ICU) quality on in-hospital mortality of veno-venous (V-V) extracorporeal membrane oxygenation (ECMO)-supported patients in China. The study involved all V-V ECMO-supported patients in 318 of 1700 tertiary hospitals from 2017 to 2019, using data from the National Clinical Improvement System and China National Critical
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A pilot study on Paxlovid therapy for hemodialysis patients with severe acute respiratory syndrome coronavirus 2 infections Front. Med. (IF 8.1) Pub Date : 2023-11-18 Xu Hao, Zhiyao Bao, Ranran Dai, Xiaojing Wu, Xin Li, Muyin Zhang, Hao Li, Lili Xu, Panpan Qiao, Xuefei Liu, Weiting Hu, Ze Zhang, Jie Fang, Min Zhou, Weiming Wang, Jieming Qu
We aimed to investigate the safety and efficacy of nirmatrelvir/ritonavir (Paxlovid) therapy for hemodialysis-dependent patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Thirteen hemodialysis patients infected with the Omicron variant of SARS-CoV-2 from April 3 to May 30, 2022, were recruited. Laboratory parameters and chest CT (computed tomography) imaging were
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Distinct immune escape and microenvironment between RG-like and pri-OPC-like glioma revealed by single-cell RNA-seq analysis Front. Med. (IF 8.1) Pub Date : 2023-11-13 Weiwei Xian, Mohammad Asad, Shuai Wu, Zhixin Bai, Fengjiao Li, Junfeng Lu, Gaoyu Zu, Erin Brintnell, Hong Chen, Ying Mao, Guomin Zhou, Bo Liao, Jinsong Wu, Edwin Wang, Linya You
The association of neurogenesis and gliogenesis with glioma remains unclear. By conducting single-cell RNA-seq analyses on 26 gliomas, we reported their classification into primitive oligodendrocyte precursor cell (pri-OPC)-like and radial glia (RG)-like tumors and validated it in a public cohort and TCGA glioma. The RG-like tumors exhibited wild-type isocitrate dehydrogenase and tended to carry EGFR
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Early-life famine exposure, adulthood obesity patterns, and risk of low-energy fracture Front. Med. (IF 8.1) Pub Date : 2023-11-08 Hongyan Qi, Chunyan Hu, Jie Zhang, Lin Lin, Shuangyuan Wang, Hong Lin, Xiaojing Jia, Yuanyue Zhu, Yi Zhang, Xueyan Wu, Mian Li, Min Xu, Yu Xu, Tiange Wang, Zhiyun Zhao, Weiqing Wang, Yufang Bi, Meng Dai, Yuhong Chen, Jieli Lu
Malnutrition in early life increases the risk of osteoporosis, but the association of early-life undernutrition combined with adulthood obesity patterns with low-energy fracture remains unknown. This study included 5323 community-dwelling subjects aged ⩾40 years from China. Early-life famine exposure was identified based on the participants’ birth dates. General obesity was assessed using the body
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Discovery of small molecule degraders for modulating cell cycle Front. Med. (IF 8.1) Pub Date : 2023-11-08 Liguo Wang, Zhouli Yang, Guangchen Li, Yongbo Liu, Chao Ai, Yu Rao
The cell cycle is a complex process that involves DNA replication, protein expression, and cell division. Dysregulation of the cell cycle is associated with various diseases. Cyclin-dependent kinases (CDKs) and their corresponding cyclins are major proteins that regulate the cell cycle. In contrast to inhibition, a new approach called proteolysis-targeting chimeras (PROTACs) and molecular glues can
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Metabolic interventions combined with CTLA-4 and PD-1/PD-L1 blockade for the treatment of tumors: mechanisms and strategies Front. Med. (IF 8.1) Pub Date : 2023-10-28 Liming Liao, Huilin Xu, Yuhan Zhao, Xiaofeng Zheng
Immunotherapies based on immune checkpoint blockade (ICB) have significantly improved patient outcomes and offered new approaches to cancer therapy over the past decade. To date, immune checkpoint inhibitors (ICIs) of CTLA-4 and PD-1/PD-L1 represent the main class of immunotherapy. Blockade of CTLA-4 and PD-1/PD-L1 has shown remarkable efficacy in several specific types of cancers, however, a large
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Phase separation in cGAS-STING signaling Front. Med. (IF 8.1) Pub Date : 2023-10-31 Quanjin Li, Pu Gao
Biomolecular condensates formed by phase separation are widespread and play critical roles in many physiological and pathological processes. cGAS-STING signaling functions to detect aberrant DNA signals to initiate anti-infection defense and antitumor immunity. At the same time, cGAS-STING signaling must be carefully regulated to maintain immune homeostasis. Interestingly, exciting recent studies have
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A randomized, controlled, open label non-inferiority trial of intravenous ferric carboxymaltose versus iron sucrose in patients with iron deficiency anemia in China Front. Med. (IF 8.1) Pub Date : 2023-10-28 Jie Jin, Zhihua Ran, Emanuele Noseda, Bernard Roubert, Matthieu Marty, Anna Mezzacasa, Udo Michael Göring
Iron deficiency (ID) and ID anemia (IDA) pose significant public health concerns in China. Although iron sucrose (IS) treatment is well-established in the country, ferric carboxymaltose (FCM) offers the advantage of higher doses and fewer infusions. This open label, randomized, controlled, non-inferiority trial was conducted at multiple sites in China to compare the outcomes of FCM (maximum of 2 doses
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Association of TRMT2B gene variants with juvenile amyotrophic lateral sclerosis Front. Med. (IF 8.1) Pub Date : 2023-10-24 Yanling Liu, Xi He, Yanchun Yuan, Bin Li, Zhen Liu, Wanzhen Li, Kaixuan Li, Shuo Tan, Quan Zhu, Zhengyan Tang, Feng Han, Ziqiang Wu, Lu Shen, Hong Jiang, Beisha Tang, Jian Qiu, Zhengmao Hu, Junling Wang
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by progressive degeneration of motor neurons, and it demonstrates high clinical heterogeneity and complex genetic architecture. A variation within TRMT2B (c.1356G>T; p.K452N) was identified to be associated with ALS in a family comprising two patients with juvenile ALS (JALS). Two missense variations and one splicing
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Tumor-derived exosomes induce initial activation by exosomal CD19 antigen but impair the function of CD19-specific CAR T-cells via TGF-β signaling Front. Med. (IF 8.1) Pub Date : 2023-10-23 Yuanyuan Hao, Panpan Chen, Shanshan Guo, Mengyuan Li, Xueli Jin, Minghuan Zhang, Wenhai Deng, Ping Li, Wen Lei, Aibin Liang, Wenbin Qian
Tumor-derived exosomes (TEXs) enriched in immune suppressive molecules predominantly drive T-cell dysfunction and impair antitumor immunity. Chimeric antigen receptor (CAR) T-cell therapy has emerged as a promising treatment for refractory and relapsed hematological malignancies, but whether lymphoma TEXs have the same impact on CAR T-cell remains unclear. Here, we demonstrated that B-cell lymphoma-derived
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Panoramic variation analysis of a family with neurodevelopmental disorders caused by biallelic loss-of-function variants in TMEM141, DDHD2, and LHFPL5 Front. Med. (IF 8.1) Pub Date : 2023-10-14 Liwei Sun, Xueting Yang, Amjad Khan, Xue Yu, Han Zhang, Shirui Han, Xiaerbati Habulieti, Yang Sun, Rongrong Wang, Xue Zhang
Highly clinical and genetic heterogeneity of neurodevelopmental disorders presents a major challenge in clinical genetics and medicine. Panoramic variation analysis is imperative to analyze the disease phenotypes resulting from multilocus genomic variation. Here, a Pakistani family with parental consanguinity was presented, characterized with severe intellectual disability (ID), spastic paraplegia
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Haploinsufficiency of Lipin3 leads to hypertriglyceridemia and obesity by disrupting the expression and nucleocytoplasmic localization of Lipin1 Front. Med. (IF 8.1) Pub Date : 2023-09-30 Fang Wang, Yuxing Liu, Yi Dong, Meifang Zhao, Hao Huang, Jieyuan Jin, Liangliang Fan, Rong Xiang
Lipin proteins including Lipin 1–3 act as transcriptional co-activators and phosphatidic acid phosphohydrolase enzymes, which play crucial roles in lipid metabolism. However, little is known about the function of Lipin3 in triglyceride (TG) metabolism. Here, we identified a novel mutation (NM_001301860: p.1835A>T/p.D612V) of Lipin3 in a large family with hypertriglyceridemia (HTG) and obesity through
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BGB-A445, a novel non-ligand-blocking agonistic anti-OX40 antibody, exhibits superior immune activation and antitumor effects in preclinical models Front. Med. (IF 8.1) Pub Date : 2023-09-25 Beibei Jiang, Tong Zhang, Minjuan Deng, Wei Jin, Yuan Hong, Xiaotong Chen, Xin Chen, Jing Wang, Hongjia Hou, Yajuan Gao, Wenfeng Gong, Xing Wang, Haiying Li, Xiaosui Zhou, Yingcai Feng, Bo Zhang, Bin Jiang, Xueping Lu, Lijie Zhang, Yang Li, Weiwei Song, Hanzi Sun, Zuobai Wang, Xiaomin Song, Zhirong Shen, Xuesong Liu, Kang Li, Lai Wang, Ye Liu
OX40 is a costimulatory receptor that is expressed primarily on activated CD4+, CD8+, and regulatory T cells. The ligation of OX40 to its sole ligand OX40L potentiates T cell expansion, differentiation, and activation and also promotes dendritic cells to mature to enhance their cytokine production. Therefore, the use of agonistic anti-OX40 antibodies for cancer immunotherapy has gained great interest
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Topological reorganization and functional alteration of distinct genomic components in gallbladder cancer Front. Med. (IF 8.1) Pub Date : 2023-09-18 Guoqiang Li, Peng Pu, Mengqiao Pan, Xiaoling Weng, Shimei Qiu, Yiming Li, Sk Jahir Abbas, Lu Zou, Ke Liu, Zheng Wang, Ziyu Shao, Lin Jiang, Wenguang Wu, Yun Liu, Rong Shao, Fatao Liu, Yingbin Liu
Altered three-dimensional architecture of chromatin influences various genomic regulators and subsequent gene expression in human cancer. However, knowledge of the topological rearrangement of genomic hierarchical layers in cancer is largely limited. Here, by taking advantage of in situ Hi-C, RNA-sequencing, and chromatin immunoprecipitation sequencing (ChIP-seq), we investigated structural reorganization
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Immunometabolism: a new dimension in immunotherapy resistance Front. Med. (IF 8.1) Pub Date : 2023-09-19 Chaoyue Xiao, Wei Xiong, Yiting Xu, Ji’an Zou, Yue Zeng, Junqi Liu, Yurong Peng, Chunhong Hu, Fang Wu
Immune checkpoint inhibitors (ICIs) have demonstrated unparalleled clinical responses and revolutionized the paradigm of tumor treatment, while substantial patients remain unresponsive or develop resistance to ICIs as a single agent, which is traceable to cellular metabolic dysfunction. Although dysregulated metabolism has long been adjudged as a hallmark of tumor, it is now increasingly accepted that
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Lack of CFAP54 causes primary ciliary dyskinesia in a mouse model and human patients Front. Med. (IF 8.1) Pub Date : 2023-09-19 Xinyue Zhao, Haijun Ge, Wenshuai Xu, Chongsheng Cheng, Wangji Zhou, Yan Xu, Junping Fan, Yaping Liu, Xinlun Tian, Kai-Feng Xu, Xue Zhang
Primary ciliary dyskinesia (PCD) is a highly heterogeneous recessive inherited disorder. FAP54, the homolog of CFAP54 in Chlamydomonas reinhardtii, was previously demonstrated as the C1d projection of the central microtubule apparatus of flagella. A Cfap54 knockout mouse model was then reported to have PCD-relevant phenotypes. Through whole-exome sequencing, compound heterozygous variants c.2649_2657delinC
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Heterogeneity of the tumor immune microenvironment and clinical interventions Front. Med. (IF 8.1) Pub Date : 2023-09-20 Zheng Jin, Qin Zhou, Jia-Nan Cheng, Qingzhu Jia, Bo Zhu
The tumor immune microenvironment (TIME) is broadly composed of various immune cells, and its heterogeneity is characterized by both immune cells and stromal cells. During the course of tumor formation and progression and anti-tumor treatment, the composition of the TIME becomes heterogeneous. Such immunological heterogeneity is not only present between populations but also exists on temporal and spatial
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Extracellular vesicle-carried GTF2I from mesenchymal stem cells promotes the expression of tumor-suppressive FAT1 and inhibits stemness maintenance in thyroid carcinoma Front. Med. (IF 8.1) Pub Date : 2023-09-14 Jie Shao, Wenjuan Wang, Baorui Tao, Zihao Cai, Haixia Li, Jinhong Chen
Through bioinformatics predictions, we identified that GTF2I and FAT1 were downregulated in thyroid carcinoma (TC). Further, Pearson’s correlation coefficient revealed a positive correlation between GTF2I expression and FAT1 expression. Therefore, we selected them for this present study, where the effects of bone marrow mesenchymal stem cell-derived EVs (BMSDs-EVs) enriched with GTF2I were evaluated
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GID complex regulates the differentiation of neural stem cells by destabilizing TET2 Front. Med. (IF 8.1) Pub Date : 2023-09-14 Meiling Xia, Rui Yan, Wenjuan Wang, Meng Zhang, Zhigang Miao, Bo Wan, Xingshun Xu
Brain development requires a delicate balance between self-renewal and differentiation in neural stem cells (NSC), which rely on the precise regulation of gene expression. Ten-eleven translocation 2 (TET2) modulates gene expression by the hydroxymethylation of 5-methylcytosine in DNA as an important epigenetic factor and participates in the neuronal differentiation. Yet, the regulation of TET2 in the
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Minimal residual disease in solid tumors: an overview Front. Med. (IF 8.1) Pub Date : 2023-09-14 Yarui Ma, Jingbo Gan, Yinlei Bai, Dandan Cao, Yuchen Jiao
Minimal residual disease (MRD) is termed as the small numbers of remnant tumor cells in a subset of patients with tumors. Liquid biopsy is increasingly used for the detection of MRD, illustrating the potential of MRD detection to provide more accurate management for cancer patients. As new techniques and algorithms have enhanced the performance of MRD detection, the approach is becoming more widely
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High frequency of alternative splicing variants of the oncogene Focal Adhesion Kinase in neuroendocrine tumors of the pancreas and breast Front. Med. (IF 8.1) Pub Date : 2023-09-08 Dawei Xie, Zheng Wang, Beibei Sun, Liwei Qu, Musheng Zeng, Lin Feng, Mingzhou Guo, Guizhen Wang, Jihui Hao, Guangbiao Zhou
The characteristic genetic abnormality of neuroendocrine neoplasms (NENs), a heterogeneous group of tumors found in various organs, remains to be identified. Here, based on the analysis of the splicing variants of an oncogene Focal Adhesion Kinase (FAK) in The Cancer Genome Atlas datasets that contain 9193 patients of 33 cancer subtypes, we found that Box 6/Box 7-containing FAK variants (FAK6/7) were
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Berberine alleviates myocardial diastolic dysfunction by modulating Drp1-mediated mitochondrial fission and Ca2+ homeostasis in a murine model of HFpEF Front. Med. (IF 8.1) Pub Date : 2023-09-01 Miyesaier Abudureyimu, Mingjie Yang, Xiang Wang, Xuanming Luo, Junbo Ge, Hu Peng, Yingmei Zhang, Jun Ren
Heart failure with preserved ejection fraction (HFpEF) displays normal or near-normal left ventricular ejection fraction, diastolic dysfunction, cardiac hypertrophy, and poor exercise capacity. Berberine, an isoquinoline alkaloid, possesses cardiovascular benefits. Adult male mice were assigned to chow or high-fat diet with L-NAME (“two-hit” model) for 15 weeks. Diastolic function was assessed using
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ADT-OH improves intestinal barrier function and remodels the gut microbiota in DSS-induced colitis Front. Med. (IF 8.1) Pub Date : 2023-07-29 Zhiqian Bi, Jia Chen, Xiaoyao Chang, Dangran Li, Yingying Yao, Fangfang Cai, Huangru Xu, Jian Cheng, Zichun Hua, Hongqin Zhuang
Owing to the increasing incidence and prevalence of inflammatory bowel disease (IBD) worldwide, effective and safe treatments for IBD are urgently needed. Hydrogen sulfide (H2S) is an endogenous gasotransmitter and plays an important role in inflammation. To date, H2S-releasing agents are viewed as potential anti-inflammatory drugs. The slow-releasing H2S donor 5-(4-hydroxyphenyl)-3H-1,2-dithiole-3-thione
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Identification of novel mutations in EYA3 and EFTUD2 in a family with craniofacial microsomia: evidence of digenic inheritance. Front. Med. (IF 8.1) Pub Date : 2023-07-29 Nuo Si,Guoqin Zhan,Xiaolu Meng,Zeya Zhang,Xin Huang,Bo Pan
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Long noncoding RNA LOC646029 functions as a ceRNA to suppress ovarian cancer progression through the miR-627-3p/SPRED1 axis Front. Med. (IF 8.1) Pub Date : 2023-07-12 Pengfei Zhao, Yating Wang, Xiao Yu, Yabing Nan, Shi Liu, Bin Li, Zhumei Cui, Zhihua Liu
Long noncoding RNAs (lncRNAs) play a crucial regulatory role in the development and progression of multiple cancers. However, the potential mechanism by which lncRNAs affect the recurrence and metastasis of ovarian cancer remains unclear. In the current study, the lncRNA LOC646029 was markedly downregulated in metastatic ovarian tumors compared with primary tumors. Gain- and loss-of-function assays
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Base editors: development and applications in biomedicine Front. Med. (IF 8.1) Pub Date : 2023-07-12 Yanhui Liang, Fangbing Chen, Kepin Wang, Liangxue Lai
Base editor (BE) is a gene-editing tool developed by combining the CRISPR/Cas system with an individual deaminase, enabling precise single-base substitution in DNA or RNA without generating a DNA double-strand break (DSB) or requiring donor DNA templates in living cells. Base editors offer more precise and secure genome-editing effects than other conventional artificial nuclease systems, such as CRISPR/Cas9
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Protection of inactivated vaccine against SARS-CoV-2 infections in patients with comorbidities: a prospective cohort study Front. Med. (IF 8.1) Pub Date : 2023-07-12 Kanchana Ngaosuwan, Kamonwan Soonklang, Chawin Warakul, Chirayu Auewarakul, Nithi Mahanonda
Protection against severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) infection of inactivated vaccines is not well characterized in people with comorbidities, who are at high risk of severe infection. We compared the risk of SARS-CoV-2 infection after complete vaccination with Sinopharm/BBIBP in people with comorbidities (e.g., autoimmune diseases, cardiovascular disease, chronic lung disease
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Analysis of the genomic landscape of primary central nervous system lymphoma using whole-genome sequencing in Chinese patients Front. Med. (IF 8.1) Pub Date : 2023-07-07 Xianggui Yuan, Teng Yu, Jianzhi Zhao, Huawei Jiang, Yuanyuan Hao, Wen Lei, Yun Liang, Baizhou Li, Wenbin Qian
Primary central nervous system lymphoma (PCNSL) is an uncommon non-Hodgkin’s lymphoma with poor prognosis. This study aimed to depict the genetic landscape of Chinese PCNSLs. Whole-genome sequencing was performed on 68 newly diagnosed Chinese PCNSL samples, whose genomic characteristics and clinicopathologic features were also analyzed. Structural variations were identified in all patients with a mean
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Liver cell therapies: cellular sources and grafting strategies Front. Med. (IF 8.1) Pub Date : 2023-07-04 Wencheng Zhang, Yangyang Cui, Yuan Du, Yong Yang, Ting Fang, Fengfeng Lu, Weixia Kong, Canjun Xiao, Jun Shi, Lola M. Reid, Zhiying He
The liver has a complex cellular composition and a remarkable regenerative capacity. The primary cell types in the liver are two parenchymal cell populations, hepatocytes and cholangiocytes, that perform most of the functions of the liver and that are helped through interactions with non-parenchymal cell types comprising stellate cells, endothelia and various hemopoietic cell populations. The regulation
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The development and benefits of metformin in various diseases Front. Med. (IF 8.1) Pub Date : 2023-07-04 Ying Dong, Yingbei Qi, Haowen Jiang, Tian Mi, Yunkai Zhang, Chang Peng, Wanchen Li, Yongmei Zhang, Yubo Zhou, Yi Zang, Jia Li
Metformin has been used for the treatment of type II diabetes mellitus for decades due to its safety, low cost, and outstanding hypoglycemic effect clinically. The mechanisms underlying these benefits are complex and still not fully understood. Inhibition of mitochondrial respiratory-chain complex I is the most described downstream mechanism of metformin, leading to reduced ATP production and activation
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Liver-directed treatment is associated with improved survival and increased response to immune checkpoint blockade in metastatic uveal melanoma: results from a retrospective multicenter trial Front. Med. (IF 8.1) Pub Date : 2023-07-04 Elias A. T. Koch, Anne Petzold, Anja Wessely, Edgar Dippel, Markus Eckstein, Anja Gesierich, Ralf Gutzmer, Jessica C. Hassel, Harald Knorr, Nicole Kreuzberg, Ulrike Leiter, Carmen Loquai, Friedegund Meier, Markus Meissner, Peter Mohr, Claudia Pföhler, Farnaz Rahimi, Dirk Schadendorf, Max Schlaak, Kai-Martin Thoms, Selma Ugurel, Jochen Utikal, Michael Weichenthal, Beatrice Schuler-Thurner, Carola Berking
Metastases of uveal melanoma (UM) spread predominantly to the liver. Due to low response rates to systemic therapies, liver-directed therapies (LDT) are commonly used for tumor control. The impact of LDT on the response to systemic treatment is unknown. A total of 182 patients with metastatic UM treated with immune checkpoint blockade (ICB) were included in this analysis. Patients were recruited from
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Discovery of the mechanisms of acupuncture in the treatment of migraine based on functional magnetic resonance imaging and omics Front. Med. (IF 8.1) Pub Date : 2023-06-30 Chong Li, Xinyi Li, Ke He, Yang Wu, Xiaoming Xie, Jiju Yang, Fan Zhang, Yang Yue, Huifeng Hao, Shaokun Zhao, Xin Li, Guihua Tian
Migraine is one of the most prevalent and disabling neurological disease, but the current pharmacotherapies show limited efficacy and often accompanied by adverse effects. Acupuncture is a promising complementary therapy, but further clinical evidence is needed. The influence of acupuncture on migraine is not an immediate effect, and its mechanism remains unclear. This study aims to provide further
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Effectiveness of inactivated COVID-19 vaccine against the severity of Omicron variant. Front. Med. (IF 8.1) Pub Date : 2023-06-27 Hao Wang,Li Liu,Tangchun Wu
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Dynein axonemal heavy chain 10 deficiency causes primary ciliary dyskinesia in humans and mice Front. Med. (IF 8.1) Pub Date : 2023-06-13 Rongchun Wang, Danhui Yang, Chaofeng Tu, Cheng Lei, Shuizi Ding, Ting Guo, Lin Wang, Ying Liu, Chenyang Lu, Binyi Yang, Shi Ouyang, Ke Gong, Zhiping Tan, Yun Deng, Yueqiu Tan, Jie Qing, Hong Luo
Primary ciliary dyskinesia (PCD) is a congenital, motile ciliopathy with pleiotropic symptoms. Although nearly 50 causative genes have been identified, they only account for approximately 70% of definitive PCD cases. Dynein axonemal heavy chain 10 (DNAH10) encodes a subunit of the inner arm dynein heavy chain in motile cilia and sperm flagella. Based on the common axoneme structure of motile cilia
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Distinct mononuclear diploid cardiac subpopulation with minimal cell–cell communications persists in embryonic and adult mammalian heart Front. Med. (IF 8.1) Pub Date : 2023-06-09 Miaomiao Zhu, Huamin Liang, Zhe Zhang, Hao Jiang, Jingwen Pu, Xiaoyi Hang, Qian Zhou, Jiacheng Xiang, Ximiao He
A small proportion of mononuclear diploid cardiomyocytes (MNDCMs), with regeneration potential, could persist in adult mammalian heart. However, the heterogeneity of MNDCMs and changes during development remains to be illuminated. To this end, 12 645 cardiac cells were generated from embryonic day 17.5 and postnatal days 2 and 8 mice by single-cell RNA sequencing. Three cardiac developmental paths
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Hyperosmolarity promotes macrophage pyroptosis by driving the glycolytic reprogramming of corneal epithelial cells in dry eye disease Front. Med. (IF 8.1) Pub Date : 2023-06-02 Yu Han, Yu Zhang, Kelan Yuan, Yaying Wu, Xiuming Jin, Xiaodan Huang
Tear film hyperosmolarity plays a core role in the development of dry eye disease (DED) by mediating the disruption of ocular surface homeostasis and triggering inflammation in ocular surface epithelium. In this study, the mechanisms involving the hyperosmolar microenvironment, glycolysis mediating metabolic reprogramming, and pyroptosis were explored clinically, in vitro, and in vivo. Data from DED
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Progress and challenges in RET-targeted cancer therapy Front. Med. (IF 8.1) Pub Date : 2023-05-03 Xueqing Hu, Ujjwol Khatri, Tao Shen, Jie Wu
The rearranged during transfection (RET) is a receptor protein tyrosine kinase. Oncogenic RET fusions or mutations are found most often in non-small cell lung cancer (NSCLC) and in thyroid cancer, but also increasingly in various types of cancers at low rates. In the last few years, two potent and selective RET protein tyrosine kinase inhibitors (TKIs), pralsetinib (BLU-667) and selpercatinib (LOXO-292
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ACSL5, a prognostic factor in acute myeloid leukemia, modulates the activity of Wnt/β-catenin signaling by palmitoylation modification Front. Med. (IF 8.1) Pub Date : 2023-05-03 Wenle Ye, Jinghan Wang, Jiansong Huang, Xiao He, Zhixin Ma, Xia Li, Xin Huang, Fenglin Li, Shujuan Huang, Jiajia Pan, Jingrui Jin, Qing Ling, Yungui Wang, Yongping Yu, Jie Sun, Jie Jin
Acyl-CoA synthetase long chain family member 5 (ACSL5), is a member of the acyl-CoA synthetases (ACSs) family that activates long chain fatty acids by catalyzing the synthesis of fatty acyl-CoAs. The dysregulation of ACSL5 has been reported in some cancers, such as glioma and colon cancers. However, little is known about the role of ACSL5 in acute myeloid leukemia (AML). We found that the expression
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Zooming in and out of ferroptosis in human disease Front. Med. (IF 8.1) Pub Date : 2023-05-01 Xue Wang, Ye Zhou, Junxia Min, Fudi Wang
Ferroptosis is defined as an iron-dependent regulated form of cell death driven by lipid peroxidation. In the past decade, it has been implicated in the pathogenesis of various diseases that together involve almost every organ of the body, including various cancers, neurodegenerative diseases, cardiovascular diseases, lung diseases, liver diseases, kidney diseases, endocrine metabolic diseases, iron-overload-related