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  • Organ function support in patients with coronavirus disease 2019: Tongji experience.
    Front. Med. (IF 1.847) Pub Date : 2020-05-14
    Yong Li,Fan He,Ning Zhou,Jia Wei,Zeyang Ding,Luyun Wang,Peng Chen,Shuiming Guo,Binhao Zhang,Xiaoning Wan,Wei Zhu,

    Coronavirus disease 2019 (COVID-19) is a highly contagious disease and a serious threat to human health. COVID-19 can cause multiple organ dysfunction, such as respiratory and circulatory failure, liver and kidney injury, disseminated intravascular coagulation, and thromboembolism, and even death. The World Health Organization reports that the mortality rate of severe-type COVID-19 is over 50%. Currently

    更新日期:2020-05-14
  • Neurological manifestations of patients with COVID-19: potential routes of SARS-CoV-2 neuroinvasion from the periphery to the brain.
    Front. Med. (IF 1.847) Pub Date : 2020-05-04
    Zhengqian Li,Taotao Liu,Ning Yang,Dengyang Han,Xinning Mi,Yue Li,Kaixi Liu,Alain Vuylsteke,Hongbing Xiang,Xiangyang Guo

    Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2), has caused a global pandemic in only 3 months. In addition to major respiratory distress, characteristic neurological manifestations are also described, indicating that SARS-CoV-2 may be an underestimated opportunistic pathogen of the brain. Based on previous studies of neuroinvasive human respiratory

    更新日期:2020-05-04
  • Serum uric acid and risk of incident diabetes in middle-aged and elderly Chinese adults: prospective cohort study.
    Front. Med. (IF 1.847) Pub Date : 2020-04-29
    Di Cheng,Chunyan Hu,Rui Du,Hongyan Qi,Lin Lin,Xueyan Wu,Lina Ma,Kui Peng,Mian Li,Min Xu,Yu Xu,Yufang Bi,Weiqing Wang,Yuhong Chen,Jieli Lu

    The association between serum uric acid and the risk of incident diabetes in Chinese adults remains unknown. This study aimed to investigate this association in a community-dwelling population aged ≥ 40 years in Shanghai, China. Oral glucose tole3rance test was conducted during baseline and follow-up visits. Relative risk regression was utilized to examine the associations between baseline gender-specific

    更新日期:2020-04-29
  • Biological properties and clinical applications of berberine.
    Front. Med. (IF 1.847) Pub Date : 2020-04-25
    Danyang Song,Jianyu Hao,Daiming Fan

    Berberine, an isoquinoline alkaloid isolated from the Chinese herb Coptis chinensis and other Berberis plants, has a wide range of pharmacological properties. Berberine can be used to treat many diseases, such as cancer and digestive, metabolic, cardiovascular, and neurological diseases. Berberine has protective capacities in digestive diseases. It can inhibit toxins and bacteria, including Helicobacter

    更新日期:2020-04-25
  • Thanks to all medical workers fighting against COVID-19.
    Front. Med. (IF 1.847) Pub Date : 2020-04-22
    Xiao-Ping Chen

    更新日期:2020-04-22
  • Advances in COVID-19: the virus, the pathogenesis, and evidence-based control and therapeutic strategies.
    Front. Med. (IF 1.847) Pub Date : 2020-04-21
    Guangbiao Zhou,Saijuan Chen,Zhu Chen

    Since the outbreak of the COVID-19 pandemic in early December 2019, 81 174 confirmed cases and 3242 deaths have been reported in China as of March 19, 2020. The Chinese people and government have contributed huge efforts to combat this disease, resulting in significant improvement of the situation, with 58 new cases (34 were imported cases) and 11 new deaths reported on March 19, 2020. However, as

    更新日期:2020-04-21
  • Clinical characteristics of 19 neonates born to mothers with COVID-19.
    Front. Med. (IF 1.847) Pub Date : 2020-04-13
    Wei Liu,Jing Wang,Wenbin Li,Zhaoxian Zhou,Siying Liu,Zhihui Rong

    The aim of this study was to investigate the clinical characteristics of neonates born to SARS-CoV-2 infected mothers and increase the current knowledge on the perinatal consequences of COVID-19. Nineteen neonates were admitted to Tongji Hospital from January 31 to February 29, 2020. Their mothers were clinically diagnosed or laboratory-confirmed with COVID-19. We prospectively collected and analyzed

    更新日期:2020-04-13
  • Cerebral regional and network characteristics in asthma patients: a resting-state fMRI study
    Front. Med. (IF 1.847) Pub Date : 2020-04-08
    Siyi Li, Peilin Lv, Min He, Wenjing Zhang, Jieke Liu, Yao Gong, Ting Wang, Qiyong Gong, Yulin Ji, Su Lui

    Asthma is a serious health problem that involves not only the respiratory system but also the central nervous system. Previous studies identified either regional or network alterations in patients with asthma, but inconsistent results were obtained. A key question remains unclear: are the regional and neural network deficits related or are they two independent characteristics in asthma? Answering this

    更新日期:2020-04-08
  • Oxidative stress and diabetes: antioxidative strategies
    Front. Med. (IF 1.847) Pub Date : 2020-04-04
    Pengju Zhang, Tao Li, Xingyun Wu, Edouard C. Nice, Canhua Huang, Yuanyuan Zhang

    Diabetes mellitus is one of the major public health problems worldwide. Considerable recent evidence suggests that the cellular reduction-oxidation (redox) imbalance leads to oxidative stress and subsequent occurrence and development of diabetes and related complications by regulating certain signaling pathways involved in β-cell dysfunction and insulin resistance. Reactive oxide species (ROS) can

    更新日期:2020-04-04
  • Coronavirus disease 2019 (COVID-19): a clinical update.
    Front. Med. (IF 1.847) Pub Date : 2020-04-02
    Min Zhou,Xinxin Zhang,Jieming Qu

    Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has posed a significant threat to global health. It caused a total of 80 868 confirmed cases and 3101 deaths in Chinese mainland until March 8, 2020. This novel virus spread mainly through respiratory droplets and close contact. As disease progressed, a series of complications tend to develop