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Endophilin A2 controls touch and mechanical allodynia via kinesin-mediated Piezo2 trafficking Mil. Med. Res. (IF 21.1) Pub Date : 2024-03-12 Man-Xiu Xie, Ren-Chun Lai, Yi-Bin Xiao, Xi Zhang, Xian-Ying Cao, Xiao-Yu Tian, An-Nan Chen, Zi-Yi Chen, Yan Cao, Xiao Li, Xiao-Long Zhang
Tactile and mechanical pain are crucial to our interaction with the environment, yet the underpinning molecular mechanism is still elusive. Endophilin A2 (EndoA2) is an evolutionarily conserved protein that is documented in the endocytosis pathway. However, the role of EndoA2 in the regulation of mechanical sensitivity and its underlying mechanisms are currently unclear. Male and female C57BL/6 mice
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Targeting vulnerable microcircuits in the ventral hippocampus of male transgenic mice to rescue Alzheimer-like social memory loss Mil. Med. Res. (IF 21.1) Pub Date : 2024-03-11 Hui-Yang Lei, Gui-Lin Pi, Ting He, Rui Xiong, Jing-Ru Lv, Jia-Le Liu, Dong-Qin Wu, Meng-Zhu Li, Kun Shi, Shi-Hong Li, Na-Na Yu, Yang Gao, Hui-Ling Yu, Lin-Yu Wei, Xin Wang, Qiu-Zhi Zhou, Pei-Lin Zou, Jia-Yang Zhou, Ying-Zhou Liu, Nai-Ting Shen, Jie Yang, Dan Ke, Qun Wang, Gong-Ping Liu, Xi-Fei Yang, Jian-Zhi Wang, Ying Yang
Episodic memory loss is a prominent clinical manifestation of Alzheimer’s disease (AD), which is closely related to tau pathology and hippocampal impairment. Due to the heterogeneity of brain neurons, the specific roles of different brain neurons in terms of their sensitivity to tau accumulation and their contribution to AD-like social memory loss remain unclear. Therefore, further investigation is
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Emerging roles of ADP-dependent glucokinase in prostate cancer Mil. Med. Res. (IF 21.1) Pub Date : 2024-02-27 Xu Zhang
Currently, the standard clinical practice involves the predominant use of androgen deprivation therapy to treat advanced prostate cancer (PCa), which often inevitably progresses into castration-resistant PCa [1]. Because of its unfavorable prognosis and limited treatment alternatives, studies have emphasized the pressing requirement for novel therapeutic targets to enhance the efficacy of advanced
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CT whole lung radiomic nomogram: a potential biomarker for lung function evaluation and identification of COPD Mil. Med. Res. (IF 21.1) Pub Date : 2024-02-20 Tao-Hu Zhou, Xiu-Xiu Zhou, Jiong Ni, Yan-Qing Ma, Fang-Yi Xu, Bing Fan, Yu Guan, Xin-Ang Jiang, Xiao-Qing Lin, Jie Li, Yi Xia, Xiang Wang, Yun Wang, Wen-Jun Huang, Wen-Ting Tu, Peng Dong, Zhao-Bin Li, Shi-Yuan Liu, Li Fan
Computed tomography (CT) plays a great role in characterizing and quantifying changes in lung structure and function of chronic obstructive pulmonary disease (COPD). This study aimed to explore the performance of CT-based whole lung radiomic in discriminating COPD patients and non-COPD patients. This retrospective study was performed on 2785 patients who underwent pulmonary function examination in
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Biomaterial-based mechanical regulation facilitates scarless wound healing with functional skin appendage regeneration Mil. Med. Res. (IF 21.1) Pub Date : 2024-02-18 Ying-Ying Li, Shuai-Fei Ji, Xiao-Bing Fu, Yu-Feng Jiang, Xiao-Yan Sun
Scar formation resulting from burns or severe trauma can significantly compromise the structural integrity of skin and lead to permanent loss of skin appendages, ultimately impairing its normal physiological function. Accumulating evidence underscores the potential of targeted modulation of mechanical cues to enhance skin regeneration, promoting scarless repair by influencing the extracellular microenvironment
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ADP-dependent glucokinase: the ancient, archaeal key to prostate cancer Mil. Med. Res. (IF 21.1) Pub Date : 2024-02-12 Marcin M. Kamiński
The December 2023 issue of the Military Medical Research brings out an astounding discovery by Xu et al. [1] demonstrating a key role of the mysterious enzyme ADP-dependent glucokinase (ADPGK) in the cellular metabolism of prostate cancer (PCa). The ADPGKs are enzymes typically found in thermophilic archaea where they mediate the indispensable, first step of glucose metabolism, i.e. phosphorylation
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Deciphering the molecular interplay and tumorigenesis in hepatocellular carcinoma through insights into FBXL6 and KRASG12D Mil. Med. Res. (IF 21.1) Pub Date : 2024-02-08 Qiang Cai, Quazi T. H. Shubhra
Liver cancer, particularly hepatocellular carcinoma, remains a formidable challenge in medical research and requires a deeper understanding of its molecular underpinnings. In a fascinating recent study published in Military Medical Research, Xiong et al. [1] revealed the complex roles of F-box and leucine-rich repeat 6 (FBXL6) and Kirsten rat sarcoma (KRAS)G12D in the pathogenesis of liver cancer.
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In situ genetic engineering of host T-cells based on acellular scaffold strategy: a big but also small step for solid tumor immunotherapy Mil. Med. Res. (IF 21.1) Pub Date : 2024-02-03 Shu-Yan Han, Zi-Xuan Zhao, Jun Wu
The advent of targeted T-cell therapy, with chimeric antigen receptor (CAR) T-cell therapy as the most prominent example, has yielded significant clinical efficacy for both relapsed and refractory hematological malignancies. However, this form of T-cell immunotherapy is often accompanied by severe systemic toxicities, suboptimal response rates, and host immune rejection in clinical settings, which
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Alleviating mitochondrial dysfunction in diabetic cardiomyopathy through the Adipsin and Irak2 pathways Mil. Med. Res. (IF 21.1) Pub Date : 2024-02-01 Mabel L. Cummins, Grace Delmonte, Skylar Wechsler, Joseph J. Schlesinger
Diabetic cardiomyopathy (DCM) is a major cause of heart failure in diabetic patients. It progresses asymptomatically prior to the onset of severe cardiac symptoms [1]; therefore, elucidating the underlying mechanisms of DCM is critical to providing early treatment options. This commentary elaborates on the findings of Jiang et al. [2], who investigated the role of adipokine hormone, Adipsin, as a cardioprotective
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Nickel’s carcinogenicity: the need of more studies to progress Mil. Med. Res. (IF 21.1) Pub Date : 2024-01-25 Consolato M. Sergi
Dear Editor, On March 8–15, 2022, a board of international scientists assembled in Lyon to evaluate the carcinogenicity of cobalt metal, cobalt(II) salts, antimony trioxide, and weapons-grade tungsten alloy harboring nickel and cobalt [1]. The 131st International Agency for Research on Cancer (IARC) Monograph is the result of a 6–9-month work of perusing the literature, slide evaluation, data interpretation
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Antimicrobial resistance crisis: could artificial intelligence be the solution? Mil. Med. Res. (IF 21.1) Pub Date : 2024-01-23 Guang-Yu Liu, Dan Yu, Mei-Mei Fan, Xu Zhang, Ze-Yu Jin, Christoph Tang, Xiao-Fen Liu
Antimicrobial resistance is a global public health threat, and the World Health Organization (WHO) has announced a priority list of the most threatening pathogens against which novel antibiotics need to be developed. The discovery and introduction of novel antibiotics are time-consuming and expensive. According to WHO’s report of antibacterial agents in clinical development, only 18 novel antibiotics
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Monitoring of urinary iodine concentration in naval pilots: should iodine be supplemented or limited at coastal stations? Mil. Med. Res. (IF 21.1) Pub Date : 2024-01-22 Jia Zeng, Qi Li, Xiang Lu, Dan-Dan Liu, Rong-Guan Jiao, Yan-Qing Jiang, Yan-Bing Liu, Wan-Qing Xu, Jun Ma, Guo-Li Gu
Dear Editor, In recent years, there has been a significant upward trend in the detection rate of thyroid diseases among military flight personnel [1]. Thyroid diseases not only pose a serious threat to the health of flight personnel but also have negative impacts on the aviation safety and combat effectiveness of troops. It has been confirmed that the occurrence and progression of thyroid diseases
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Gulf War illness with or without post-traumatic stress disorder: differential symptoms and immune responses Mil. Med. Res. (IF 21.1) Pub Date : 2024-01-12 Faith Nguyen, Ashok K. Shetty
Over one-third of 700,000 military personnel who served in the first Gulf War (GW) suffer from an assortment of symptoms, including cognitive and memory problems, musculoskeletal pain, gastrointestinal discomfort, fatigue, and respiratory issues [1, 2]. The precise etiology of Gulf War illness (GWI) is unclear. However, epidemiological and preclinical studies imply that exposures to the prophylactic
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GPR65 as a potential novel therapeutic target for the treatment of hepatic fibrosis Mil. Med. Res. (IF 21.1) Pub Date : 2024-01-08 Leila Gobejishvili
Hepatic fibrosis is a consequence of chronic liver disease, which can lead to cirrhosis and liver failure. There is no Food and Drugs Administration approved therapy for liver fibrosis to date; hence, identifying effective therapeutic targets is an urgent need. Hepatic macrophages play a critical role in both initiation and progression of fibrosis. While resident liver macrophages, Kupffer cells are
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Acellular scaffold-based approach for in situ genetic engineering of host T-cells in solid tumor immunotherapy Mil. Med. Res. (IF 21.1) Pub Date : 2024-01-04 Hiren Y. Dandia, Mamatha M. Pillai, Deepak Sharma, Meghna Suvarna, Neha Dalal, Ayush Madhok, Arvind Ingle, Shubhada V. Chiplunkar, Sanjeev Galande, Prakriti Tayalia
Targeted T-cell therapy has emerged as a promising strategy for the treatment of hematological malignancies. However, its application to solid tumors presents significant challenges due to the limited accessibility and heterogeneity. Localized delivery of tumor-specific T-cells using biomaterials has shown promise, however, procedures required for genetic modification and generation of a sufficient
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Interleukin-1 receptor associated kinase 2 is a functional downstream regulator of complement factor D that controls mitochondrial fitness in diabetic cardiomyopathy Mil. Med. Res. (IF 21.1) Pub Date : 2024-01-03 Stanislovas S. Jankauskas, Fahimeh Varzideh, Pasquale Mone, Urna Kansakar, Francesco Di Lorenzo, Angela Lombardi, Gaetano Santulli
Diabetic cardiomyopathy is a disorder of the cardiac muscle that affects patients with diabetes. The exact mechanisms underlying diabetic cardiomyopathy are mostly unknown, but several factors have been implicated in the pathogenesis of the disease and its progression towards heart failure, including endothelial dysfunction, autonomic neuropathy, metabolic alterations, oxidative stress, and alterations
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Disentangling the effects of PTSD from Gulf War Illness in male veterans via a systems-wide analysis of immune cell, cytokine, and symptom measures Mil. Med. Res. (IF 21.1) Pub Date : 2024-01-02 Esha Sultana, Nandan Shastry, Rishabh Kasarla, Jacob Hardy, Fanny Collado, Kristina Aenlle, Maria Abreu, Emily Sisson, Kimberly Sullivan, Nancy Klimas, Travis J. A. Craddock
One-third of veterans returning from the 1990–1991 Gulf War reported a myriad of symptoms including cognitive dysfunction, skin rashes, musculoskeletal discomfort, and fatigue. This symptom cluster is now referred to as Gulf War Illness (GWI). As the underlying mechanisms of GWI have yet to be fully elucidated, diagnosis and treatment are based on symptomatic presentation. One confounding factor tied
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Elevated FBXL6 activates both wild-type KRAS and mutant KRASG12D and drives HCC tumorigenesis via the ERK/mTOR/PRELID2/ROS axis in mice Mil. Med. Res. (IF 21.1) Pub Date : 2023-12-20 Hao-Jun Xiong, Hong-Qiang Yu, Jie Zhang, Lei Fang, Di Wu, Xiao-Tong Lin, Chuan-Ming Xie
Kirsten rat sarcoma (KRAS) and mutant KRASG12D have been implicated in human cancers, but it remains unclear whether their activation requires ubiquitination. This study aimed to investigate whether and how F-box and leucine-rich repeat 6 (FBXL6) regulates KRAS and KRASG12D activity in hepatocellular carcinoma (HCC). We constructed transgenic mouse strains LC (LSL-Fbxl6KI/+;Alb-Cre, n = 13), KC (L
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The applied principles of EEG analysis methods in neuroscience and clinical neurology Mil. Med. Res. (IF 21.1) Pub Date : 2023-12-19 Hao Zhang, Qing-Qi Zhou, He Chen, Xiao-Qing Hu, Wei-Guang Li, Yang Bai, Jun-Xia Han, Yao Wang, Zhen-Hu Liang, Dan Chen, Feng-Yu Cong, Jia-Qing Yan, Xiao-Li Li
Electroencephalography (EEG) is a non-invasive measurement method for brain activity. Due to its safety, high resolution, and hypersensitivity to dynamic changes in brain neural signals, EEG has aroused much interest in scientific research and medical fields. This article reviews the types of EEG signals, multiple EEG signal analysis methods, and the application of relevant methods in the neuroscience
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Apoptosis-resistant megakaryocytes produce large and hyperreactive platelets in response to radiation injury Mil. Med. Res. (IF 21.1) Pub Date : 2023-12-19 Chang-Hong Du, Yi-Ding Wu, Ke Yang, Wei-Nian Liao, Li Ran, Chao-Nan Liu, Shu-Zhen Zhang, Kuan Yu, Jun Chen, Yong Quan, Mo Chen, Ming-Qiang Shen, Hong Tang, Shi-Lei Chen, Song Wang, Jing-Hong Zhao, Tian-Min Cheng, Jun-Ping Wang
The essential roles of platelets in thrombosis have been well recognized. Unexpectedly, thrombosis is prevalent during thrombocytopenia induced by cytotoxicity of biological, physical and chemical origins, which could be suffered by military personnel and civilians during chemical, biological, radioactive, and nuclear events. Especially, thrombosis is considered a major cause of mortality from radiation
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Pre-hospital application of REBOA for life-threatening hemorrhage Mil. Med. Res. (IF 21.1) Pub Date : 2023-12-13 Xiao-Mei Tian, Wei Hu, Feng-Yong Liu
Dear Editor, Most battlefield casualties occur prior to the arrival of medical facilities. Uncontrollable hemorrhage accounts for more than 90% of those potentially survivable battlefield casualties [1]. In both military and civilian conditions, non-compressible torso hemorrhage always caused rapid exsanguination and high mortality rates before definitive treatment [2]. More than half of the deaths
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ADP-dependent glucokinase controls metabolic fitness in prostate cancer progression Mil. Med. Res. (IF 21.1) Pub Date : 2023-12-12 Hang Xu, Yi-Fan Li, Xian-Yan-Ling Yi, Xiao-Nan Zheng, Yang Yang, Yan Wang, Da-Zhou Liao, Jia-Peng Zhang, Ping Tan, Xing-Yu Xiong, Xi Jin, Li-Na Gong, Shi Qiu, De-Hong Cao, Hong Li, Qiang Wei, Lu Yang, Jian-Zhong Ai
Cell metabolism plays a pivotal role in tumor progression, and targeting cancer metabolism might effectively kill cancer cells. We aimed to investigate the role of hexokinases in prostate cancer (PCa) and identify a crucial target for PCa treatment. The Cancer Genome Atlas (TCGA) database, online tools and clinical samples were used to assess the expression and prognostic role of ADP-dependent glucokinase
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Adipsin inhibits Irak2 mitochondrial translocation and improves fatty acid β-oxidation to alleviate diabetic cardiomyopathy Mil. Med. Res. (IF 21.1) Pub Date : 2023-12-11 Meng-Yuan Jiang, Wan-Rong Man, Xue-Bin Zhang, Xiao-Hua Zhang, Yu Duan, Jie Lin, Yan Zhang, Yang Cao, De-Xi Wu, Xiao-Fei Shu, Lei Xin, Hao Wang, Xiao Zhang, Cong-Ye Li, Xiao-Ming Gu, Xuan Zhang, Dong-Dong Sun
Diabetic cardiomyopathy (DCM) causes the myocardium to rely on fatty acid β-oxidation for energy. The accumulation of intracellular lipids and fatty acids in the myocardium usually results in lipotoxicity, which impairs myocardial function. Adipsin may play an important protective role in the pathogenesis of DCM. The aim of this study is to investigate the regulatory effect of Adipsin on DCM lipotoxicity
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Targeting NR1D1 in organ injury: challenges and prospects Mil. Med. Res. (IF 21.1) Pub Date : 2023-12-11 Zi-Yin Zhang-sun, Xue-Zeng Xu, Germaine Escames, Wang-Rui Lei, Lin Zhao, Ya-Zhe Zhou, Ye Tian, Ya-Nan Ren, Darío Acuña-Castroviejo, Yang Yang
Nuclear receptor subfamily 1, group D, member 1 (NR1D1, also known as REV-ERBα) belongs to the nuclear receptor (NR) family, and is a heme-binding component of the circadian clock that consolidates circadian oscillators. In addition to repressing the transcription of multiple clock genes associated with circadian rhythms, NR1D1 has a wide range of downstream target genes that are intimately involved
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BET inhibitors potentiate melanoma ferroptosis and immunotherapy through AKR1C2 inhibition Mil. Med. Res. (IF 21.1) Pub Date : 2023-12-04 Yu Meng, Hui-Yan Sun, Yi He, Qian Zhou, Yi-Huang Liu, Hui Su, Ming-Zhu Yin, Fu-Rong Zeng, Xiang Chen, Guang-Tong Deng
Dear Editor, Ferroptosis, an iron-dependent form of cell death driven by overwhelming lipid peroxidation, represents a vulnerability in cancers, and therapeutic strategies to further potentiate ferroptosis hold great potential for melanoma treatment. To systematically identify drugs that sensitize ferroptosis, we initially calculated ferroptosis score (FPS) using our published algorithm model [1],
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Targeting the epigenome to reinvigorate T cells for cancer immunotherapy Mil. Med. Res. (IF 21.1) Pub Date : 2023-12-04 Dian Xiong, Lu Zhang, Zhi-Jun Sun
Cancer immunotherapy using immune-checkpoint inhibitors (ICIs) has revolutionized the field of cancer treatment; however, ICI efficacy is constrained by progressive dysfunction of CD8+ tumor-infiltrating lymphocytes (TILs), which is termed T cell exhaustion. This process is driven by diverse extrinsic factors across heterogeneous tumor immune microenvironment (TIME). Simultaneously, tumorigenesis entails
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Mesenchymal stem cell-derived extracellular vesicles in skin wound healing: the risk of senescent drift induction in secretome-based therapeutics Mil. Med. Res. (IF 21.1) Pub Date : 2023-11-30 Anna Smirnova, Elena Yatsenko, Denis Baranovskii, Ilya Klabukov
Regulatory changes in senescent cells could potentially affect the composition of extracellular vehicles (EVs), specifically altering their size and cargo. As a result, the released senescent EVs contain an unpredictable cocktail of growth factors and cytokines. These biomolecules have dual effects, potentially guiding the induction of senescence in affected cells and promoting an inflammation-related
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From immunology to artificial intelligence: revolutionizing latent tuberculosis infection diagnosis with machine learning Mil. Med. Res. (IF 21.1) Pub Date : 2023-11-28 Lin-Sheng Li, Ling Yang, Li Zhuang, Zhao-Yang Ye, Wei-Guo Zhao, Wen-Ping Gong
Latent tuberculosis infection (LTBI) has become a major source of active tuberculosis (ATB). Although the tuberculin skin test and interferon-gamma release assay can be used to diagnose LTBI, these methods can only differentiate infected individuals from healthy ones but cannot discriminate between LTBI and ATB. Thus, the diagnosis of LTBI faces many challenges, such as the lack of effective biomarkers
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Human urinary cells for functional wound healing with sweat gland restoration Mil. Med. Res. (IF 21.1) Pub Date : 2023-11-28 Shuai-Fei Ji, Lai-Xian Zhou, Ying-Ying Li, Jiang-Bing Xiang, Hua-Ting Chen, Yi-Qiong Liu, Xiao-Bing Fu, Xiao-Yan Sun
Dear Editor, The large defects of the skin caused by burns or trauma can result in disruption of the structure and function of the skin, as well as irreversible loss of skin appendages, such as sweat glands (SG). As the important modulator of temperature homeostasis, SG damage triggers heat intolerance and thermoregulatory dysfunction, which poses a considerable threat to health and quality of life
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Targeting GPR65 alleviates hepatic inflammation and fibrosis by suppressing the JNK and NF-κB pathways Mil. Med. Res. (IF 21.1) Pub Date : 2023-11-25 Kun Zhang, Meng-Xia Zhang, Xiao-Xiang Meng, Jing Zhu, Jia-Jun Wang, Yi-Fan He, Ye-Hua Li, Si-Cong Zhao, Zhe-Min Shi, Li-Na Zheng, Tao Han, Wei Hong
G-protein coupled receptors (GPCRs) are recognized as attractive targets for drug therapy. However, it remains poorly understood how GPCRs, except for a few chemokine receptors, regulate the progression of liver fibrosis. Here, we aimed to reveal the role of GPR65, a proton-sensing receptor, in liver fibrosis and to elucidate the underlying mechanism. The expression level of GPR65 was evaluated in
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Cognitive function among military veterans with STEM occupations Mil. Med. Res. (IF 21.1) Pub Date : 2023-11-20 Justin T. McDaniel, Kevin N. Hascup, Erin R. Hascup, Ugochukwu G. Ezigbo, Amanda M. Weidhuner, Harvey Henson, David L. Albright
Dear Editor, There is limited research on the relationship between science, technology, engineering, and mathematics (STEM) occupational history and cognitive function in later life, especially among military veterans, who may be at greater risk for later-life cognitive decline. This study examines a nationally representative sample of military veterans to address this gap in knowledge. We obtained
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Insights into the underlying pathogenesis and therapeutic potential of endoplasmic reticulum stress in degenerative musculoskeletal diseases Mil. Med. Res. (IF 21.1) Pub Date : 2023-11-09 Ze-Qin Wen, Jun Lin, Wen-Qing Xie, Yun-Han Shan, Ge-Hua Zhen, Yu-Sheng Li
Degenerative musculoskeletal diseases are structural and functional failures of the musculoskeletal system, including osteoarthritis, osteoporosis, intervertebral disc degeneration (IVDD), and sarcopenia. As the global population ages, degenerative musculoskeletal diseases are becoming more prevalent. However, the pathogenesis of degenerative musculoskeletal diseases is not fully understood. Previous
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Caveolin-1 is critical for hepatic iron storage capacity in the development of nonalcoholic fatty liver disease Mil. Med. Res. (IF 21.1) Pub Date : 2023-11-08 Guang-Hui Deng, Chao-Feng Wu, Yun-Jia Li, Hao Shi, Wei-Chao Zhong, Mu-Keng Hong, Jun-Jie Li, Jia-Min Zhao, Chang Liu, Meng-Chen Qin, Zhi-Yun Zeng, Wei-Min Zhang, Ken Kin Lam Yung, Zhi-Ping Lv, Lei Gao
Nonalcoholic fatty liver disease (NAFLD) is associated with disordered lipid and iron metabolism. Our previous study has substantiated the pivotal role of Caveolin-1 (Cav-1) in protecting hepatocytes and mediating iron metabolism in the liver. This study aimed to explore the specific mechanisms underlying the regulation of iron metabolism by Cav-1 in NAFLD. Hepatocyte-specific Cav-1 overexpression
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Insights gained from single-cell analysis of chimeric antigen receptor T-cell immunotherapy in cancer Mil. Med. Res. (IF 21.1) Pub Date : 2023-11-08 Lu Tang, Zhong-Pei Huang, Heng Mei, Yu Hu
Advances in chimeric antigen receptor (CAR)-T cell therapy have significantly improved clinical outcomes of patients with relapsed or refractory hematologic malignancies. However, progress is still hindered as clinical benefit is only available for a fraction of patients. A lack of understanding of CAR-T cell behaviors in vivo at the single-cell level impedes their more extensive application in clinical
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The correlation between gut microbiome and atrial fibrillation: pathophysiology and therapeutic perspectives Mil. Med. Res. (IF 21.1) Pub Date : 2023-11-07 Na Li, Ling Wang, Lei Li, Meng-Zhao Yang, Qing-Xiang Wang, Xi-Wen Bai, Feng Gao, Yi-Qiang Yuan, Zu-Jiang Yu, Zhi-Gang Ren
Regulation of gut microbiota and its impact on human health is the theme of intensive research. The incidence and prevalence of atrial fibrillation (AF) are continuously escalating as the global population ages and chronic disease survival rates increase; however, the mechanisms are not entirely clarified. It is gaining awareness that alterations in the assembly, structure, and dynamics of gut microbiota
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How to use the Surveillance, Epidemiology, and End Results (SEER) data: research design and methodology Mil. Med. Res. (IF 21.1) Pub Date : 2023-10-31 Wen-Qiang Che, Yuan-Jie Li, Chi-Kwan Tsang, Yu-Jiao Wang, Zheng Chen, Xiang-Yu Wang, An-Ding Xu, Jun Lyu
In the United States (US), the Surveillance, Epidemiology, and End Results (SEER) program is the only comprehensive source of population-based information that includes stage of cancer at the time of diagnosis and patient survival data. This program aims to provide a database about cancer incidence and survival for studies of surveillance and the development of analytical and methodological tools in
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Regulatory T cells in skin regeneration and wound healing Mil. Med. Res. (IF 21.1) Pub Date : 2023-10-23 Samuel Knoedler, Leonard Knoedler, Martin Kauke-Navarro, Yuval Rinkevich, Gabriel Hundeshagen, Leila Harhaus, Ulrich Kneser, Bohdan Pomahac, Dennis P. Orgill, Adriana C. Panayi
As the body’s integumentary system, the skin is vulnerable to injuries. The subsequent wound healing processes aim to restore dermal and epidermal integrity and functionality. To this end, multiple tissue-resident cells and recruited immune cells cooperate to efficiently repair the injured tissue. Such temporally- and spatially-coordinated interplay necessitates tight regulation to prevent collateral
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Elucidating regulatory processes of intense physical activity by multi-omics analysis Mil. Med. Res. (IF 21.1) Pub Date : 2023-10-18 Ernesto S. Nakayasu, Marina A. Gritsenko, Young-Mo Kim, Jennifer E. Kyle, Kelly G. Stratton, Carrie D. Nicora, Nathalie Munoz, Kathleen M. Navarro, Daniel Claborne, Yuqian Gao, Karl K. Weitz, Vanessa L. Paurus, Kent J. Bloodsworth, Kelsey A. Allen, Lisa M. Bramer, Fernando Montes, Kathleen A. Clark, Grant Tietje, Justin Teeguarden, Kristin E. Burnum-Johnson
Physiological and biochemical processes across tissues of the body are regulated in response to the high demands of intense physical activity in several occupations, such as firefighting, law enforcement, military, and sports. A better understanding of such processes can ultimately help improve human performance and prevent illnesses in the work environment. To study regulatory processes in intense
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White-light-induced synthesis of injectable alginate-based composite hydrogels for rapid hemostasis Mil. Med. Res. (IF 21.1) Pub Date : 2023-10-17 Meng-De Zhang, Xing Huang, Zhao Li, Wei Song, Yi Kong, Chao Zhang, Li-Ting Liang, Yu-Yan Huang, Ya-Xin Tan, Yu Feng, Qing-Hua Liu, Yu-Xia Zhao, Xiao-Bing Fu, Sha Huang
Dear Editor, Timely and effective hemostasis is of great significance for reducing body damage and mortality of patients [1]. Alginate is generally considered to be an excellent hemostatic polymer-based biomaterial and has been approved by the Food and Drug Administration as Generally Recognized as Safe [2]. However, the violent crosslinking reaction and unstable structure at the wound site limit its
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Multifaceted functions of Drp1 in hypoxia/ischemia-induced mitochondrial quality imbalance: from regulatory mechanism to targeted therapeutic strategy Mil. Med. Res. (IF 21.1) Pub Date : 2023-10-13 Shuai Hao, He Huang, Rui-Yan Ma, Xue Zeng, Chen-Yang Duan
Hypoxic-ischemic injury is a common pathological dysfunction in clinical settings. Mitochondria are sensitive organelles that are readily damaged following ischemia and hypoxia. Dynamin-related protein 1 (Drp1) regulates mitochondrial quality and cellular functions via its oligomeric changes and multiple modifications, which plays a role in mediating the induction of multiple organ damage during hypoxic-ischemic
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Research on the development methodology for clinical practice guidelines for organic integration of traditional Chinese and Western medicine Mil. Med. Res. (IF 21.1) Pub Date : 2023-09-27 Ying-Hui Jin, Yan-Ping Wang, Ying-Lan Xie, Gui-Hua Tian, Xiao-Yu Zhang, Nan-Nan Shi, Ke-Hu Yang, Xin Sun, Yao-Long Chen, Da-Rong Wu, Xin-Feng Guo, Long Ge, Chen Zhao, Cheng Lu, Yin Jiang, Jing Guo, Si-Yu Yan, Yong-Bo Wang, Qiao Huang, Xiang-Ying Ren, Ying-Yue Rao, Yun-Yun Wang, Meng-Qian Yuan, Xian-Tao Zeng, Hong-Cai Shang
Integrated traditional Chinese medicine (TCM) and Western medicine (WM) is a new medical science grounded in the knowledge bases of both TCM and WM, which then forms a unique modern medical system in China. Integrated TCM and WM has a long history in China, and has made important achievements in the process of clinical diagnosis and treatment. However, the methodological defects in currently published
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Deep learning-based lung sound analysis for intelligent stethoscope Mil. Med. Res. (IF 21.1) Pub Date : 2023-09-26 Dong-Min Huang, Jia Huang, Kun Qiao, Nan-Shan Zhong, Hong-Zhou Lu, Wen-Jin Wang
Auscultation is crucial for the diagnosis of respiratory system diseases. However, traditional stethoscopes have inherent limitations, such as inter-listener variability and subjectivity, and they cannot record respiratory sounds for offline/retrospective diagnosis or remote prescriptions in telemedicine. The emergence of digital stethoscopes has overcome these limitations by allowing physicians to
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Enhancing the clinical relevance of haemorrhage prediction models in trauma Mil. Med. Res. (IF 21.1) Pub Date : 2023-09-20 Sankalp Tandle, Jared M. Wohlgemut, Max E. R. Marsden, Erhan Pisirir, Evangelia Kyrimi, Rebecca S. Stoner, William Marsh, Zane B. Perkins, Nigel R. M. Tai
We read with interest the recent systematic review “Artificial intelligence and machine learning for hemorrhagic trauma care” by Peng et al. [1], which evaluated literature on machine learning (ML) in the management of traumatic haemorrhage. We thank the authors for their contribution to the role of ML in trauma. Prediction of relevant patient outcomes may inform clinicians about the severity of injury
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RARRES2’s impact on lipid metabolism in triple-negative breast cancer: a pathway to brain metastasis Mil. Med. Res. (IF 21.1) Pub Date : 2023-09-12 Quazi T. H. Shubhra
Breast cancer brain metastasis (BCBrM) is a crucial and hard area of research which guarantees an urgent need to understand the underlying molecular mechanisms. A recent study by Li et al. [1] published in Military Medical Research investigated the role of retinoic acid receptor responder 2 (RARRES2) in regulating lipid metabolism in BCBrM, highlighting the clinical relevance of alterations in lipid
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Heat exposure and hospitalizations for chronic kidney disease in China: a nationwide time series study in 261 major Chinese cities Mil. Med. Res. (IF 21.1) Pub Date : 2023-09-05 Fu-Lin Wang, Wan-Zhou Wang, Fei-Fei Zhang, Su-Yuan Peng, Huai-Yu Wang, Rui Chen, Jin-Wei Wang, Peng-Fei Li, Yang Wang, Ming-Hui Zhao, Chao Yang, Lu-Xia Zhang
Climate change profoundly shapes the population health at the global scale. However, there was still insufficient and inconsistent evidence for the association between heat exposure and chronic kidney disease (CKD). In the present study, we studied the association of heat exposure with hospitalizations for cause-specific CKD using a national inpatient database in China during the study period of hot
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Research advances in smart responsive-hydrogel dressings with potential clinical diabetic wound healing properties Mil. Med. Res. (IF 21.1) Pub Date : 2023-08-23 Ying Chen, Xing Wang, Sheng Tao, Qi Wang, Pan-Qin Ma, Zi-Biao Li, Yun-Long Wu, Da-Wei Li
The treatment of chronic and non-healing wounds in diabetic patients remains a major medical problem. Recent reports have shown that hydrogel wound dressings might be an effective strategy for treating diabetic wounds due to their excellent hydrophilicity, good drug-loading ability and sustained drug release properties. As a typical example, hyaluronic acid dressing (Healoderm) has been demonstrated
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Bioengineered skin organoids: from development to applications Mil. Med. Res. (IF 21.1) Pub Date : 2023-08-22 Zi-Xuan Hong, Shun-Tian Zhu, Hao Li, Jing-Zhi Luo, Yu Yang, Yang An, Xi Wang, Kai Wang
Significant advancements have been made in recent years in the development of highly sophisticated skin organoids. Serving as three-dimensional models that mimic human skin, these organoids have evolved into complex structures and are increasingly recognized as effective alternatives to traditional culture models and human skin due to their ability to overcome the limitations of two-dimensional systems
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Physical exercise reverses immuno-cold tumor microenvironment via inhibiting SQLE in non-small cell lung cancer Mil. Med. Res. (IF 21.1) Pub Date : 2023-08-18 Zhi-Wen Luo, Ya-Ying Sun, Wei Xia, Jun-Ying Xu, Dong-Jing Xie, Chun-Meng Jiao, Ji-Ze Dong, Hui Chen, Ren-Wen Wan, Shi-Yi Chen, Jie Mei, Wen-Jun Mao
Dear Editor, Physical exercise has been shown to be associated with reduced cancer incidence and cancer-associated mortality [1, 2], but the underlying mechanisms are obscure. Immunometabolic regulation has emerged as one of the most prominent mechanisms explaining the effects of exercise on cancer [1, 2]. Physical exercise primarily lowers blood cholesterol and triglycerides, and protects against
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Spatial transcriptomics: recent developments and insights in respiratory research Mil. Med. Res. (IF 21.1) Pub Date : 2023-08-17 Wen-Jia Wang, Liu-Xi Chu, Li-Yong He, Ming-Jing Zhang, Kai-Tong Dang, Chen Gao, Qin-Yu Ge, Zhou-Guang Wang, Xiang-Wei Zhao
The respiratory system’s complex cellular heterogeneity presents unique challenges to researchers in this field. Although bulk RNA sequencing and single-cell RNA sequencing (scRNA-seq) have provided insights into cell types and heterogeneity in the respiratory system, the relevant specific spatial localization and cellular interactions have not been clearly elucidated. Spatial transcriptomics (ST)
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Mesenchymal stem cell-derived extracellular vesicles in skin wound healing: roles, opportunities and challenges Mil. Med. Res. (IF 21.1) Pub Date : 2023-08-17 Jia-Yi Ding, Min-Jiang Chen, Ling-Feng Wu, Gao-Feng Shu, Shi-Ji Fang, Zhao-Yu Li, Xu-Ran Chu, Xiao-Kun Li, Zhou-Guang Wang, Jian-Song Ji
Skin wounds are characterized by injury to the skin due to trauma, tearing, cuts, or contusions. As such injuries are common to all human groups, they may at times represent a serious socioeconomic burden. Currently, increasing numbers of studies have focused on the role of mesenchymal stem cell (MSC)-derived extracellular vesicles (EVs) in skin wound repair. As a cell-free therapy, MSC-derived EVs
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The marriage of immunomodulatory, angiogenic, and osteogenic capabilities in a piezoelectric hydrogel tissue engineering scaffold for military medicine Mil. Med. Res. (IF 21.1) Pub Date : 2023-07-31 Ping Wu, Lin Shen, Hui-Fan Liu, Xiang-Hui Zou, Juan Zhao, Yu Huang, Yu-Fan Zhu, Zhao-Yu Li, Chao Xu, Li-Hua Luo, Zhi-Qiang Luo, Min-Hao Wu, Lin Cai, Xiao-Kun Li, Zhou-Guang Wang
Most bone-related injuries to grassroots troops are caused by training or accidental injuries. To establish preventive measures to reduce all kinds of trauma and improve the combat effectiveness of grassroots troops, it is imperative to develop new strategies and scaffolds to promote bone regeneration. In this study, a porous piezoelectric hydrogel bone scaffold was fabricated by incorporating polydopamine
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RARRES2 regulates lipid metabolic reprogramming to mediate the development of brain metastasis in triple negative breast cancer Mil. Med. Res. (IF 21.1) Pub Date : 2023-07-25 Yi-Qun Li, Fang-Zhou Sun, Chun-Xiao Li, Hong-Nan Mo, Yan-Tong Zhou, Dan Lv, Jing-Tong Zhai, Hai-Li Qian, Fei Ma
Triple negative breast cancer (TNBC), the most aggressive subtype of breast cancer, is characterized by a high incidence of brain metastasis (BrM) and a poor prognosis. As the most lethal form of breast cancer, BrM remains a major clinical challenge due to its rising incidence and lack of effective treatment strategies. Recent evidence suggested a potential role of lipid metabolic reprogramming in
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China stroke surveillance report 2021 Mil. Med. Res. (IF 21.1) Pub Date : 2023-07-19 Wen-Jun Tu, Long-De Wang
Since 2015, stroke has become the leading cause of death and disability in China, posing a significant threat to the health of its citizens as a major chronic non-communicable disease. According to the China Stroke High-risk Population Screening and Intervention Program, an estimated 17.8 million [95% confidence interval (CI) 17.6–18.0 million] adults in China had experienced a stroke in 2020, with
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Targeting miRNA by CRISPR/Cas in cancer: advantages and challenges Mil. Med. Res. (IF 21.1) Pub Date : 2023-07-17 Bashdar Mahmud Hussen, Mohammed Fatih Rasul, Snur Rasool Abdullah, Hazha Jamal Hidayat, Goran Sedeeq Hama Faraj, Fattma Abodi Ali, Abbas Salihi, Aria Baniahmad, Soudeh Ghafouri-Fard, Milladur Rahman, Mark C. Glassy, Wojciech Branicki, Mohammad Taheri
Clustered regulatory interspaced short palindromic repeats (CRISPR) has changed biomedical research and provided entirely new models to analyze every aspect of biomedical sciences during the last decade. In the study of cancer, the CRISPR/CRISPR-associated protein (Cas) system opens new avenues into issues that were once unknown in our knowledge of the noncoding genome, tumor heterogeneity, and precision
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Activatable fluorescent probes for imaging and diagnosis of rheumatoid arthritis Mil. Med. Res. (IF 21.1) Pub Date : 2023-07-14 Pan Luo, Fu-Qiang Gao, Wei Sun, Jun-You Li, Cheng Wang, Qing-Yu Zhang, Zhi-Zhuo Li, Peng Xu
Rheumatoid arthritis (RA) is a systemic autoimmune disease that is primarily manifested as synovitis and polyarticular opacity and typically leads to serious joint damage and irreversible disability, thus adversely affecting locomotion ability and life quality. Consequently, good prognosis heavily relies on the early diagnosis and effective therapeutic monitoring of RA. Activatable fluorescent probes
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Correction to: Bioengineered materials with selective antimicrobial toxicity in biomedicine Mil. Med. Res. (IF 21.1) Pub Date : 2023-07-12 Pooyan Makvandi, Hao Song, Cynthia K. Y. Yiu, Rossella Sartorius, Ehsan Nazarzadeh Zare, Navid Rabiee, Wei-Xi Wu, Ana Cláudia Paiva-Santos, Xiang-Dong Wang, Cheng-Zhong Yu, Franklin R. Tay
Correction to: Military Medical Research (2023) 10:8 https://doi.org/10.1186/s40779-023-00443-1 Following publication of the original article [1], it was noticed that the order of the affiliation 1 and affiliation 2 is incorrect. The correct order of the affiliations are shown below: 1 The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People’s Hospital, Quzhou 324000, Zhejiang, China
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What benefit can be obtained from magnetic resonance imaging diagnosis with artificial intelligence in prostate cancer compared with clinical assessments? Mil. Med. Res. (IF 21.1) Pub Date : 2023-06-26 Li-Tao Zhao, Zhen-Yu Liu, Wan-Fang Xie, Li-Zhi Shao, Jian Lu, Jie Tian, Jian-Gang Liu
The present study aimed to explore the potential of artificial intelligence (AI) methodology based on magnetic resonance (MR) images to aid in the management of prostate cancer (PCa). To this end, we reviewed and summarized the studies comparing the diagnostic and predictive performance for PCa between AI and common clinical assessment methods based on MR images and/or clinical characteristics, thereby
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Advancing our understanding of monocyte HLA-DR, S100A9, and the potential for individualized therapies in sepsis Mil. Med. Res. (IF 21.1) Pub Date : 2023-06-25 Guillaume Monneret
By definition, sepsis refers to a life threatening organ dysfunction due to a dysregulated host response to an infection [1]. More precisely, sepsis triggers a multifaceted response characterized by a simultaneous manifestation of pro-inflammatory and anti-inflammatory elements that disrupt mechanisms intended to maintain homeostasis. Initially, an overwhelming hyperinflammatory reaction ensues, resulting
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Single-cell transcriptome profiling of sepsis identifies HLA-DRlowS100Ahigh monocytes with immunosuppressive function Mil. Med. Res. (IF 21.1) Pub Date : 2023-06-19 Ren-Qi Yao, Peng-Yue Zhao, Zhi-Xuan Li, Yu-Yang Liu, Li-Yu Zheng, Yu Duan, Lu Wang, Rong-Li Yang, Hong-Jun Kang, Ji-Wei Hao, Jing-Yan Li, Ning Dong, Yao Wu, Xiao-Hui Du, Feng Zhu, Chao Ren, Guo-Sheng Wu, Zhao-Fan Xia, Yong-Ming Yao
Sustained yet intractable immunosuppression is commonly observed in septic patients, resulting in aggravated clinical outcomes. However, due to the substantial heterogeneity within septic patients, precise indicators in deciphering clinical trajectories and immunological alterations for septic patients remain largely lacking. We adopted cross-species, single-cell RNA sequencing (scRNA-seq) analysis
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A comprehensive look at the psychoneuroimmunoendocrinology of spinal cord injury and its progression: mechanisms and clinical opportunities Mil. Med. Res. (IF 21.1) Pub Date : 2023-06-09 Miguel A. Ortega, Oscar Fraile-Martinez, Cielo García-Montero, Sergio Haro, Miguel Ángel Álvarez-Mon, Diego De Leon-Oliva, Ana M. Gomez-Lahoz, Jorge Monserrat, Mar Atienza-Pérez, David Díaz, Elisa Lopez-Dolado, Melchor Álvarez-Mon
Spinal cord injury (SCI) is a devastating and disabling medical condition generally caused by a traumatic event (primary injury). This initial trauma is accompanied by a set of biological mechanisms directed to ameliorate neural damage but also exacerbate initial damage (secondary injury). The alterations that occur in the spinal cord have not only local but also systemic consequences and virtually