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Let's talk about sex: Mechanisms of neural sexual differentiation in Bilateria WIREs Mech. Dis. (IF 3.1) Pub Date : 2024-01-07 Emma C. Roggenbuck, Elijah A. Hall, Isabel B. Hanson, Alyssa A. Roby, Katherine K. Zhang, Kyle A. Alkatib, Joseph A. Carter, Jarred E. Clewner, Anna L. Gelfius, Shiyuan Gong, Finley R. Gordon, Jolene N. Iseler, Samhita Kotapati, Marilyn Li, Areeba Maysun, Elise O. McCormick, Geetanjali Rastogi, Srijani Sengupta, Chantal U. Uzoma, Madison A. Wolkov, E. Josephine Clowney
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Walking with giants: The challenges of variant impact assessment in the giant sarcomeric protein titin WIREs Mech. Dis. (IF 3.1) Pub Date : 2023-12-29 Timir G. R. Weston, Martin Rees, Mathias Gautel, Franca Fraternali
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Appropriate patient population for future visual system axon regeneration therapies WIREs Mech. Dis. (IF 3.1) Pub Date : 2023-12-13 Sanjoy K. Bhattacharya, Chrisfouad Raif Alabiad, Krishna Kishor
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Computational modeling of angiogenesis: The importance of cell rearrangements during vascular growth WIREs Mech. Dis. (IF 3.1) Pub Date : 2023-12-12 Daria Stepanova, Helen M. Byrne, Philip K. Maini, Tomás Alarcón
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A perspective on translating genomic discoveries into targets for brain-machine interface and deep brain stimulation devices WIREs Mech. Dis. (IF 3.1) Pub Date : 2023-12-07 Wander L. Valentim, Daniel S. Tylee, Renato Polimanti
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Rationalizing a prospective coupling effect of cannabinoids with the current pharmacotherapy for melanoma treatment WIREs Mech. Dis. (IF 3.1) Pub Date : 2023-11-03 Ava Bachari, Nazim Nassar, Ellen Schanknecht, Srinivasareddy Telukutla, Terrence Jerald Piva, Nitin Mantri
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Synaptic plasticity and the role of astrocytes in central metabolic circuits WIREs Mech. Dis. (IF 3.1) Pub Date : 2023-10-13 Dominique Ameroso, Maribel Rios
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MHC class III lymphocyte antigens 6 as endogenous immunotoxins: Unlocking immunotherapy in proficient mismatch repair colorectal cancer WIREs Mech. Dis. (IF 3.1) Pub Date : 2023-10-11 Guido Giordano, Massimo Pancione
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iPSCs as a groundbreaking tool for the study of adverse drug reactions: A new avenue for personalized therapy WIREs Mech. Dis. (IF 3.1) Pub Date : 2023-09-28 Paola Rispoli, Tatiana Scandiuzzi Piovesan, Giuliana Decorti, Gabriele Stocco, Marianna Lucafò
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Two decades of heart regeneration research: Cardiomyocyte proliferation and beyond WIREs Mech. Dis. (IF 3.1) Pub Date : 2023-09-12 Herman Huang, Guo N. Huang, Alexander Y. Payumo
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Secondary glaucoma: Toward interventions based on molecular underpinnings WIREs Mech. Dis. (IF 3.1) Pub Date : 2023-09-05 Anna Mueller, Isabel Lam, Krishna Kishor, Richard K. Lee, Sanjoy Bhattacharya
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An update on the roles of transcription factor Ets1 in autoimmune diseases WIREs Mech. Dis. (IF 3.1) Pub Date : 2023-08-10 Lee Ann Garrett-Sinha
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An update on the roles of transcription factor Ets1 in autoimmune diseases WIREs Mech. Dis. (IF 3.1) Pub Date : 2023-08-10 Lee Ann Garrett-Sinha
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An update on the roles of transcription factor Ets1 in autoimmune diseases WIREs Mech. Dis. (IF 3.1) Pub Date : 2023-08-10 Lee Ann Garrett-Sinha
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Anti-microbial resistance and aging—A design for evolution WIREs Mech. Dis. (IF 3.1) Pub Date : 2023-08-08 Amrita Nepalia, Sheryl Erica Fernandes, Harpreet Singh, Shweta Rana, Deepak Kumar Saini
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Anti-microbial resistance and aging—A design for evolution WIREs Mech. Dis. (IF 3.1) Pub Date : 2023-08-08 Amrita Nepalia, Sheryl Erica Fernandes, Harpreet Singh, Shweta Rana, Deepak Kumar Saini
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Anti-microbial resistance and aging—A design for evolution WIREs Mech. Dis. (IF 3.1) Pub Date : 2023-08-08 Amrita Nepalia, Sheryl Erica Fernandes, Harpreet Singh, Shweta Rana, Deepak Kumar Saini
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Mathematical models of cystic fibrosis as a systemic disease WIREs Mech. Dis. (IF 3.1) Pub Date : 2023-08-06 Daniel V. Olivença, Jacob D. Davis, Carla M. Kumbale, Conan Y. Zhao, Samuel P. Brown, Nael A. McCarty, Eberhard O. Voit
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Mathematical models of cystic fibrosis as a systemic disease WIREs Mech. Dis. (IF 3.1) Pub Date : 2023-08-06 Daniel V. Olivença, Jacob D. Davis, Carla M. Kumbale, Conan Y. Zhao, Samuel P. Brown, Nael A. McCarty, Eberhard O. Voit
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Mathematical models of cystic fibrosis as a systemic disease WIREs Mech. Dis. (IF 3.1) Pub Date : 2023-08-06 Daniel V. Olivença, Jacob D. Davis, Carla M. Kumbale, Conan Y. Zhao, Samuel P. Brown, Nael A. McCarty, Eberhard O. Voit
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Recent insights explaining susceptibility to endometriosis—From genetics to environment WIREs Mech. Dis. (IF 3.1) Pub Date : 2023-08-02 Ana Sofia Pais, Teresa Almeida-Santos
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Recent insights explaining susceptibility to endometriosis—From genetics to environment WIREs Mech. Dis. (IF 3.1) Pub Date : 2023-08-02 Ana Sofia Pais, Teresa Almeida-Santos
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Recent insights explaining susceptibility to endometriosis—From genetics to environment WIREs Mech. Dis. (IF 3.1) Pub Date : 2023-08-02 Ana Sofia Pais, Teresa Almeida-Santos
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Alignment behavior of nerve, vascular, muscle, and intestine cells in two- and three-dimensional strategies WIREs Mech. Dis. (IF 3.1) Pub Date : 2023-07-01 Amir Jafari, Erfan Behjat, Haniyeh Malektaj, Faezeh Mobini
By harnessing structural hierarchical insights, plausibly simulate better ones imagination to figure out the best choice of methods for reaching out the unprecedented developments of the tissue engineering products as a next level. Constructing a functional tissue that incorporates two-dimensional (2D) or higher dimensions requires overcoming technological or biological limitations in order to orchestrate
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Alignment behavior of nerve, vascular, muscle, and intestine cells in two- and three-dimensional strategies WIREs Mech. Dis. (IF 3.1) Pub Date : 2023-07-01 Amir Jafari, Erfan Behjat, Haniyeh Malektaj, Faezeh Mobini
By harnessing structural hierarchical insights, plausibly simulate better ones imagination to figure out the best choice of methods for reaching out the unprecedented developments of the tissue engineering products as a next level. Constructing a functional tissue that incorporates two-dimensional (2D) or higher dimensions requires overcoming technological or biological limitations in order to orchestrate
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Alignment behavior of nerve, vascular, muscle, and intestine cells in two- and three-dimensional strategies WIREs Mech. Dis. (IF 3.1) Pub Date : 2023-07-01 Amir Jafari, Erfan Behjat, Haniyeh Malektaj, Faezeh Mobini
By harnessing structural hierarchical insights, plausibly simulate better ones imagination to figure out the best choice of methods for reaching out the unprecedented developments of the tissue engineering products as a next level. Constructing a functional tissue that incorporates two-dimensional (2D) or higher dimensions requires overcoming technological or biological limitations in order to orchestrate
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Alignment behavior of nerve, vascular, muscle, and intestine cells in two- and three-dimensional strategies. WIREs Mech. Dis. (IF 3.1) Pub Date : 2023-07-01 Amir Jafari,Erfan Behjat,Haniyeh Malektaj,Faezeh Mobini
By harnessing structural hierarchical insights, plausibly simulate better ones imagination to figure out the best choice of methods for reaching out the unprecedented developments of the tissue engineering products as a next level. Constructing a functional tissue that incorporates two-dimensional (2D) or higher dimensions requires overcoming technological or biological limitations in order to orchestrate
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MicroRNAs as powerful tool against COVID-19: Computational perspective WIREs Mech. Dis. (IF 3.1) Pub Date : 2023-06-22 Ankur Omer
Severe acute respiratory syndrome coronavirus 2 is the virus that is responsible for the current pandemic, COVID-19 (SARS-CoV-2). MiRNAs, a component of RNAi technology, belong to the family of short, noncoding ssRNAs, and may be crucial in the battle against this global threat since they are involved in regulating complex biochemical pathways and may prevent viral proliferation, translation, and host
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MicroRNAs as powerful tool against COVID-19: Computational perspective. WIREs Mech. Dis. (IF 3.1) Pub Date : 2023-06-22 Ankur Omer
Severe acute respiratory syndrome coronavirus 2 is the virus that is responsible for the current pandemic, COVID-19 (SARS-CoV-2). MiRNAs, a component of RNAi technology, belong to the family of short, noncoding ssRNAs, and may be crucial in the battle against this global threat since they are involved in regulating complex biochemical pathways and may prevent viral proliferation, translation, and host
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Astrocyte-mediated mechanisms contribute to traumatic brain injury pathology WIREs Mech. Dis. (IF 3.1) Pub Date : 2023-06-18 Carmen Muñoz-Ballester, Stefanie Robel
Astrocytes respond to traumatic brain injury (TBI) with changes to their molecular make-up and cell biology, which results in changes in astrocyte function. These changes can be adaptive, initiating repair processes in the brain, or detrimental, causing secondary damage including neuronal death or abnormal neuronal activity. The response of astrocytes to TBI is often—but not always—accompanied by the
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Astrocyte-mediated mechanisms contribute to traumatic brain injury pathology WIREs Mech. Dis. (IF 3.1) Pub Date : 2023-06-18 Carmen Muñoz-Ballester, Stefanie Robel
Astrocytes respond to traumatic brain injury (TBI) with changes to their molecular make-up and cell biology, which results in changes in astrocyte function. These changes can be adaptive, initiating repair processes in the brain, or detrimental, causing secondary damage including neuronal death or abnormal neuronal activity. The response of astrocytes to TBI is often—but not always—accompanied by the
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Astrocyte-mediated mechanisms contribute to traumatic brain injury pathology WIREs Mech. Dis. (IF 3.1) Pub Date : 2023-06-18 Carmen Muñoz-Ballester, Stefanie Robel
Astrocytes respond to traumatic brain injury (TBI) with changes to their molecular make-up and cell biology, which results in changes in astrocyte function. These changes can be adaptive, initiating repair processes in the brain, or detrimental, causing secondary damage including neuronal death or abnormal neuronal activity. The response of astrocytes to TBI is often—but not always—accompanied by the
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Astrocyte-mediated mechanisms contribute to traumatic brain injury pathology. WIREs Mech. Dis. (IF 3.1) Pub Date : 2023-06-18 Carmen Muñoz-Ballester,Stefanie Robel
Astrocytes respond to traumatic brain injury (TBI) with changes to their molecular make-up and cell biology, which results in changes in astrocyte function. These changes can be adaptive, initiating repair processes in the brain, or detrimental, causing secondary damage including neuronal death or abnormal neuronal activity. The response of astrocytes to TBI is often-but not always-accompanied by the
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Network medicine for patients' stratification: From single-layer to multi-omics WIREs Mech. Dis. (IF 3.1) Pub Date : 2023-06-15 Manuela Petti, Lorenzo Farina
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Network medicine for patients' stratification: From single-layer to multi-omics WIREs Mech. Dis. (IF 3.1) Pub Date : 2023-06-15 Manuela Petti, Lorenzo Farina
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Network medicine for patients' stratification: From single-layer to multi-omics WIREs Mech. Dis. (IF 3.1) Pub Date : 2023-06-15 Manuela Petti, Lorenzo Farina
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Network medicine for patients' stratification: From single-layer to multi-omics. WIREs Mech. Dis. (IF 3.1) Pub Date : 2023-06-15 Manuela Petti,Lorenzo Farina
Precision medicine research increasingly relies on the integrated analysis of multiple types of omics. In the era of big data, the large availability of different health-related information represents a great, but at the same time untapped, chance with a potentially fundamental role in the prevention, diagnosis and prognosis of diseases. Computational methods are needed to combine this data to create
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Aging and oocyte competence: A molecular cell perspective WIREs Mech. Dis. (IF 3.1) Pub Date : 2023-05-29 Ana Filipa Ferreira, Maria Soares, Teresa Almeida-Santos, João Ramalho-Santos, Ana Paula Sousa
Follicular microenvironment is paramount in the acquisition of oocyte competence, which is dependent on two interconnected and interdependent processes: nuclear and cytoplasmic maturation. Extensive research conducted in human and model systems has provided evidence that those processes are disturbed with female aging. In fact, advanced maternal age (AMA) is associated with a lower chance of pregnancy
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Aging and oocyte competence: A molecular cell perspective WIREs Mech. Dis. (IF 3.1) Pub Date : 2023-05-29 Ana Filipa Ferreira, Maria Soares, Teresa Almeida-Santos, João Ramalho-Santos, Ana Paula Sousa
Follicular microenvironment is paramount in the acquisition of oocyte competence, which is dependent on two interconnected and interdependent processes: nuclear and cytoplasmic maturation. Extensive research conducted in human and model systems has provided evidence that those processes are disturbed with female aging. In fact, advanced maternal age (AMA) is associated with a lower chance of pregnancy
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Aging and oocyte competence: A molecular cell perspective WIREs Mech. Dis. (IF 3.1) Pub Date : 2023-05-29 Ana Filipa Ferreira, Maria Soares, Teresa Almeida-Santos, João Ramalho-Santos, Ana Paula Sousa
Follicular microenvironment is paramount in the acquisition of oocyte competence, which is dependent on two interconnected and interdependent processes: nuclear and cytoplasmic maturation. Extensive research conducted in human and model systems has provided evidence that those processes are disturbed with female aging. In fact, advanced maternal age (AMA) is associated with a lower chance of pregnancy
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Aging and oocyte competence: A molecular cell perspective. WIREs Mech. Dis. (IF 3.1) Pub Date : 2023-05-29 Ana Filipa Ferreira,Maria Soares,Teresa Almeida-Santos,João Ramalho-Santos,Ana Paula Sousa
Follicular microenvironment is paramount in the acquisition of oocyte competence, which is dependent on two interconnected and interdependent processes: nuclear and cytoplasmic maturation. Extensive research conducted in human and model systems has provided evidence that those processes are disturbed with female aging. In fact, advanced maternal age (AMA) is associated with a lower chance of pregnancy
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Gut mycobiome: A “black box” of gut microbiome–host interactions WIREs Mech. Dis. (IF 3.1) Pub Date : 2023-05-08 Xinyue Zhao, Xiaomin Hu, Junjie Han, Ruopeng Yin, Shuyang Zhang, Hongwei Liu
Fungi, being a necessary component of the gut microbiome, potentially have direct or indirect effects on the health and illness status of the host. The gut mycobiome is an inducer of the host's immunity, maintaining intestinal homeostasis, and protecting against infections, as well as a reservoir of opportunistic microorganisms and a potential cofactor when the host is immunocompromised. In addition
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Membrane contact sites orchestrate cholesterol homeostasis that is central to vascular aging WIREs Mech. Dis. (IF 3.1) Pub Date : 2023-05-08 Wenjing Li, Yiyun Pang, Kehan Jin, Yuru Wang, Yujie Wu, Jichang Luo, Wenlong Xu, Xiao Zhang, Ran Xu, Tao Wang, Liqun Jiao
Chronological age causes structural and functional vascular deterioration and is a well-established risk factor for the development of cardiovascular diseases, leading to more than 40% of all deaths in the elderly. The etiology of vascular aging is complex; a significant impact arises from impaired cholesterol homeostasis. Cholesterol level is balanced through synthesis, uptake, transport, and esterification
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Gut mycobiome: A “black box” of gut microbiome–host interactions WIREs Mech. Dis. (IF 3.1) Pub Date : 2023-05-08 Xinyue Zhao, Xiaomin Hu, Junjie Han, Ruopeng Yin, Shuyang Zhang, Hongwei Liu
Fungi, being a necessary component of the gut microbiome, potentially have direct or indirect effects on the health and illness status of the host. The gut mycobiome is an inducer of the host's immunity, maintaining intestinal homeostasis, and protecting against infections, as well as a reservoir of opportunistic microorganisms and a potential cofactor when the host is immunocompromised. In addition
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Membrane contact sites orchestrate cholesterol homeostasis that is central to vascular aging WIREs Mech. Dis. (IF 3.1) Pub Date : 2023-05-08 Wenjing Li, Yiyun Pang, Kehan Jin, Yuru Wang, Yujie Wu, Jichang Luo, Wenlong Xu, Xiao Zhang, Ran Xu, Tao Wang, Liqun Jiao
Chronological age causes structural and functional vascular deterioration and is a well-established risk factor for the development of cardiovascular diseases, leading to more than 40% of all deaths in the elderly. The etiology of vascular aging is complex; a significant impact arises from impaired cholesterol homeostasis. Cholesterol level is balanced through synthesis, uptake, transport, and esterification
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Gut mycobiome: A “black box” of gut microbiome–host interactions WIREs Mech. Dis. (IF 3.1) Pub Date : 2023-05-08 Xinyue Zhao, Xiaomin Hu, Junjie Han, Ruopeng Yin, Shuyang Zhang, Hongwei Liu
Fungi, being a necessary component of the gut microbiome, potentially have direct or indirect effects on the health and illness status of the host. The gut mycobiome is an inducer of the host's immunity, maintaining intestinal homeostasis, and protecting against infections, as well as a reservoir of opportunistic microorganisms and a potential cofactor when the host is immunocompromised. In addition
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Membrane contact sites orchestrate cholesterol homeostasis that is central to vascular aging WIREs Mech. Dis. (IF 3.1) Pub Date : 2023-05-08 Wenjing Li, Yiyun Pang, Kehan Jin, Yuru Wang, Yujie Wu, Jichang Luo, Wenlong Xu, Xiao Zhang, Ran Xu, Tao Wang, Liqun Jiao
Chronological age causes structural and functional vascular deterioration and is a well-established risk factor for the development of cardiovascular diseases, leading to more than 40% of all deaths in the elderly. The etiology of vascular aging is complex; a significant impact arises from impaired cholesterol homeostasis. Cholesterol level is balanced through synthesis, uptake, transport, and esterification
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Gut mycobiome: A "black box" of gut microbiome-host interactions. WIREs Mech. Dis. (IF 3.1) Pub Date : 2023-05-08 Xinyue Zhao,Xiaomin Hu,Junjie Han,Ruopeng Yin,Shuyang Zhang,Hongwei Liu
Fungi, being a necessary component of the gut microbiome, potentially have direct or indirect effects on the health and illness status of the host. The gut mycobiome is an inducer of the host's immunity, maintaining intestinal homeostasis, and protecting against infections, as well as a reservoir of opportunistic microorganisms and a potential cofactor when the host is immunocompromised. In addition
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Membrane contact sites orchestrate cholesterol homeostasis that is central to vascular aging. WIREs Mech. Dis. (IF 3.1) Pub Date : 2023-05-08 Wenjing Li,Yiyun Pang,Kehan Jin,Yuru Wang,Yujie Wu,Jichang Luo,Wenlong Xu,Xiao Zhang,Ran Xu,Tao Wang,Liqun Jiao
Chronological age causes structural and functional vascular deterioration and is a well-established risk factor for the development of cardiovascular diseases, leading to more than 40% of all deaths in the elderly. The etiology of vascular aging is complex; a significant impact arises from impaired cholesterol homeostasis. Cholesterol level is balanced through synthesis, uptake, transport, and esterification
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Bioengineering approaches for nerve graft revascularization: Current concepts and future directions WIREs Mech. Dis. (IF 7.9) Pub Date : 2023-04-27 Clifford Pereira, Sabrina Valentina Lazar, Aijun Wang
Peripheral nerve injury (PNI) is the most common neurological injury in civilian and military injuries, with over 360,000 PNI procedures performed in the US yearly. Segmental loss of nerve tissue results in a nerve gap precluding a tension-free primary repair, and in these cases, interpositional autologous or acellular nerve allografts are used to bridge the gap. Graft ischemia time is a critical factor
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Bioengineering approaches for nerve graft revascularization: Current concepts and future directions WIREs Mech. Dis. (IF 3.1) Pub Date : 2023-04-27 Clifford Pereira, Sabrina Valentina Lazar, Aijun Wang
Peripheral nerve injury (PNI) is the most common neurological injury in civilian and military injuries, with over 360,000 PNI procedures performed in the US yearly. Segmental loss of nerve tissue results in a nerve gap precluding a tension-free primary repair, and in these cases, interpositional autologous or acellular nerve allografts are used to bridge the gap. Graft ischemia time is a critical factor
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Bioengineering approaches for nerve graft revascularization: Current concepts and future directions WIREs Mech. Dis. (IF 3.1) Pub Date : 2023-04-27 Clifford Pereira, Sabrina Valentina Lazar, Aijun Wang
Peripheral nerve injury (PNI) is the most common neurological injury in civilian and military injuries, with over 360,000 PNI procedures performed in the US yearly. Segmental loss of nerve tissue results in a nerve gap precluding a tension-free primary repair, and in these cases, interpositional autologous or acellular nerve allografts are used to bridge the gap. Graft ischemia time is a critical factor
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Bioengineering approaches for nerve graft revascularization: Current concepts and future directions WIREs Mech. Dis. (IF 3.1) Pub Date : 2023-04-27 Clifford Pereira, Sabrina Valentina Lazar, Aijun Wang
Peripheral nerve injury (PNI) is the most common neurological injury in civilian and military injuries, with over 360,000 PNI procedures performed in the US yearly. Segmental loss of nerve tissue results in a nerve gap precluding a tension-free primary repair, and in these cases, interpositional autologous or acellular nerve allografts are used to bridge the gap. Graft ischemia time is a critical factor
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Bioengineering approaches for nerve graft revascularization: Current concepts and future directions. WIREs Mech. Dis. (IF 3.1) Pub Date : 2023-04-27 Clifford Pereira,Sabrina Valentina Lazar,Aijun Wang
Peripheral nerve injury (PNI) is the most common neurological injury in civilian and military injuries, with over 360,000 PNI procedures performed in the US yearly. Segmental loss of nerve tissue results in a nerve gap precluding a tension-free primary repair, and in these cases, interpositional autologous or acellular nerve allografts are used to bridge the gap. Graft ischemia time is a critical factor
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A One Health approach to overcoming fungal disease and antifungal resistance WIREs Mech. Dis. (IF 7.9) Pub Date : 2023-04-26 Michael Woods, Jason A. McAlister, Jennifer Geddes-McAlister
The global burden of fungal disease poses a substantial threat to human, animal, and environmental health, endangering both human and livestock populations and creating vulnerabilities to food supplies world-wide. Antifungal drugs provide essential therapies to humans and animals against infections, while fungicides provide protection in agriculture. However, a limited arsenal of antifungal agents
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A One Health approach to overcoming fungal disease and antifungal resistance WIREs Mech. Dis. (IF 3.1) Pub Date : 2023-04-26 Michael Woods, Jason A. McAlister, Jennifer Geddes-McAlister
The global burden of fungal disease poses a substantial threat to human, animal, and environmental health, endangering both human and livestock populations and creating vulnerabilities to food supplies world-wide. Antifungal drugs provide essential therapies to humans and animals against infections, while fungicides provide protection in agriculture. However, a limited arsenal of antifungal agents
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A One Health approach to overcoming fungal disease and antifungal resistance WIREs Mech. Dis. (IF 3.1) Pub Date : 2023-04-26 Michael Woods, Jason A. McAlister, Jennifer Geddes-McAlister
The global burden of fungal disease poses a substantial threat to human, animal, and environmental health, endangering both human and livestock populations and creating vulnerabilities to food supplies world-wide. Antifungal drugs provide essential therapies to humans and animals against infections, while fungicides provide protection in agriculture. However, a limited arsenal of antifungal agents
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A One Health approach to overcoming fungal disease and antifungal resistance WIREs Mech. Dis. (IF 3.1) Pub Date : 2023-04-26 Michael Woods, Jason A. McAlister, Jennifer Geddes-McAlister
The global burden of fungal disease poses a substantial threat to human, animal, and environmental health, endangering both human and livestock populations and creating vulnerabilities to food supplies world-wide. Antifungal drugs provide essential therapies to humans and animals against infections, while fungicides provide protection in agriculture. However, a limited arsenal of antifungal agents
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A One Health approach to overcoming fungal disease and antifungal resistance. WIREs Mech. Dis. (IF 3.1) Pub Date : 2023-04-26 Michael Woods,Jason A McAlister,Jennifer Geddes-McAlister
The global burden of fungal disease poses a substantial threat to human, animal, and environmental health, endangering both human and livestock populations and creating vulnerabilities to food supplies world-wide. Antifungal drugs provide essential therapies to humans and animals against infections, while fungicides provide protection in agriculture. However, a limited arsenal of antifungal agents
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From fetus to neonate: A review of cardiovascular modeling in early life WIREs Mech. Dis. (IF 7.9) Pub Date : 2023-03-31 Robyn W. May, Gonzalo D. Maso Talou, Alys R. Clark, Jonathan P. Mynard, Joseph J. Smolich, Pablo J. Blanco, Lucas O. Müller, Thomas L. Gentles, Frank H. Bloomfield, Soroush Safaei
Computational modeling has well-established utility in the study of cardiovascular hemodynamics, with applications in medical research and, increasingly, in clinical settings to improve the diagnosis and treatment of cardiovascular diseases. Most cardiovascular models developed to date have been of the adult circulatory system; however, the perinatal period is unique as cardiovascular physiology undergoes