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  • Understanding and managing suicide risk.
    Br. Med. Bull. (IF 2.804) Pub Date : 2020-05-21
    Tiago C Zortea,Seonaid Cleare,Ambrose J Melson,Karen Wetherall,Rory C O'Connor

    BACKGROUND Suicidal behaviours and non-suicidal self-harm (NSSH) are global public health concerns that affect millions of lives. SOURCES OF DATA This review is a narrative synthesis of systematic reviews, meta-analyses of randomized control trials (RCTs) and landmark studies published in scientific journals. AREAS OF AGREEMENT Restricting access to lethal means reduces the likelihood of future suicide

    更新日期:2020-05-21
  • Posterior shoulder instability: a systematic review.
    Br. Med. Bull. (IF 2.804) Pub Date : 2020-05-18
    Umile Giuseppe Longo,Mauro Ciuffreda,Joel Locher,Carlo Casciaro,Nicholas Mannering,Nicola Maffulli,Vincenzo Denaro

    INTRODUCTION This review aims to provide information on outcomes of surgical procedures for soft tissue or bony glenoid and/or humeral abnormalities in case of posterior shoulder instability. SOURCE OF DATA A systematic review of the literature according to the PRISMA guidelines was performed. A comprehensive search of PubMed, Medline, CINAHL, Cochrane, Embase, Ovid and Google Scholar databases using

    更新日期:2020-05-18
  • The epidemiology of osteoporosis.
    Br. Med. Bull. (IF 2.804) Pub Date : 2020-05-15
    Michael A Clynes,Nicholas C Harvey,Elizabeth M Curtis,Nicholas R Fuggle,Elaine M Dennison,Cyrus Cooper

    INTRODUCTION With a worldwide ageing population, the importance of the prevention and management of osteoporotic fragility fractures is increasing over time. In this review, we discuss in detail the epidemiology of fragility fractures, how this is shaped by pharmacological interventions and how novel screening programmes can reduce the clinical and economic burden of osteoporotic fractures. SOURCES

    更新日期:2020-05-15
  • Obeticholic acid-a new therapy in PBC and NASH.
    Br. Med. Bull. (IF 2.804) Pub Date : 2020-05-15
    Roger W Chapman,Kate D Lynch

    INTRODUCTION Obeticholic acid (OCA) is a semi-synthetic hydrophobic bile acid (BA) analogue that is highly selective agonist of farnesoid X receptor (FXR), a key nuclear BA receptor, which induces expression of gut-derived hormones, in particular fibroblast growth factor 19. The resulting beneficial effects of OCA on glucose and lipid metabolism and particularly hepatic inflammation make it a candidate

    更新日期:2020-05-15
  • Non-insulin therapies in addition to insulin in Type 1 DM treatment.
    Br. Med. Bull. (IF 2.804) Pub Date : 2020-05-14
    Andrea Llano,Gerard A McKay

    INTRODUCTION Complications of Type 1 diabetes (T1DM) remain prevalent due to suboptimal glycaemic control despite advances in analogue insulin, its delivery and technological advances in glucose monitoring. Intensive insulin therapy is associated with hypoglycaemia and weight gain. Non-insulin-dependent glucose lowering strategies may provide a strategy in improving glycaemic control without hypoglycaemia

    更新日期:2020-05-14
  • The mental health status of asylum seekers in middle- to high-income countries: a synthesis of current global evidence.
    Br. Med. Bull. (IF 2.804) Pub Date : 2020-05-14
    Miriam Posselt,Heather McIntyre,Mtho Ngcanga,Thomas Lines,Nicholas Procter

    INTRODUCTION The last 5 years have witnessed a significant increase in the number of people fleeing their countries of origin and seeking refuge in host countries. By the end of 2018, there were 3.5 million asylum seekers awaiting outcomes on their applications, the majority of whom were hosted by middle- to high-income countries. This review aimed to identify and synthesize current knowledge regarding

    更新日期:2020-05-14
  • Targeted biologic therapy for asthma.
    Br. Med. Bull. (IF 2.804) Pub Date : 2020-05-15
    Gareth Hynes,Ian D Pavord

    BACKGROUND Asthma is a common and potentially serious condition affecting 300 million people worldwide. For many years, we have relied on a one-size-fits-all approach to its management, using corticosteroids and bronchodilators for all symptomatic patients. However, with more recent advances, it has become clear that asthma is a heterogeneous condition with multiple different underlying pathways. Understanding

    更新日期:2020-04-21
  • The role of the immune system in tendon healing: a systematic review.
    Br. Med. Bull. (IF 2.804) Pub Date : 2020-05-15
    Emanuele Chisari,Laura Rehak,Wasim S Khan,Nicola Maffulli

    INTRODUCTION The role of the immune system in tendon healing relies on polymorphonucleocytes, mast cells, macrophages and lymphocytes, the 'immune cells' and their cytokine production. This systematic review reports how the immune system affects tendon healing. SOURCES OF DATA We registered our protocol (registration number: CRD42019141838). After searching PubMed, Embase and Cochrane Library databases

    更新日期:2020-03-28
  • Understanding the genetic basis of congenital insensitivity to pain.
    Br. Med. Bull. (IF 2.804) Pub Date : 2020-05-15
    Ichrak Drissi,William Aidan Woods,Christopher Geoffrey Woods

    INTRODUCTION OR BACKGROUND Congenital insensitivity to pain (CIP) is caused by extremely rare Mendelian genetic disorders. CIP individuals demonstrate the unexpectedly severe consequences of painlessness. Although only a small number of causative conditions and genes are known, most have led to profound insights into human nociception. CIP gene discovery is catalyzing the manufacture of completely

    更新日期:2020-03-28
  • Therapeutic potential of microRNA in tendon injuries.
    Br. Med. Bull. (IF 2.804) Pub Date : 2020-05-15
    Lorenzo Giordano,Giovanna Della Porta,Giuseppe M Peretti,Nicola Maffulli

    INTRODUCTION The regulatory role of microRNA (miRNA) in several conditions has been studied, but their function in tendon healing remains elusive. This review summarizes how miRNAs are related to the pathogenesis of tendon injuries and highlights their clinical potential, focusing on the issues related to their delivery for clinical purposes. SOURCES OF DATA We searched multiple databases to perform

    更新日期:2020-03-28