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The natural history and burden of illness of metachromatic leukodystrophy: a systematic literature review Eur. J. Med. Res. (IF 4.2) Pub Date : 2024-03-18 Shun-Chiao Chang, Christian Stefan Eichinger, Polly Field
Metachromatic leukodystrophy (MLD; OMIM 250100 and 249900) is a rare lysosomal storage disease caused by deficient arylsulfatase A activity, leading to accumulation of sulfatides in the nervous system. This systematic literature review aimed to explore the effect of MLD on the lives of patients. The Ovid platform was used to search Embase, MEDLINE, and the Cochrane Library for articles related to the
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Construction of a gene model related to the prognosis of patients with gastric cancer receiving immunotherapy and exploration of COX7A1 gene function Eur. J. Med. Res. (IF 4.2) Pub Date : 2024-03-17 Si-yu Wang, Yu-xin Wang, Ao Shen, Xian-qi Yang, Cheng-cai Liang, Run-jie Huang, Rui Jian, Nan An, Yu-long Xiao, Li-shuai Wang, Yin Zhao, Chuan Lin, Chang-ping Wang, Zhi-ping Yuan, Shu-qiang Yuan
GC is a highly heterogeneous tumor with different responses to immunotherapy, and the positive response depends on the unique interaction between the tumor and the tumor microenvironment (TME). However, the currently available methods for prognostic prediction are not satisfactory. Therefore, this study aims to construct a novel model that integrates relevant gene sets to predict the clinical efficacy
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Predictive value of the Adult Comorbidity Evaluation 27 on adverse surgical outcomes and survival in elderly with advanced epithelial ovarian cancer undergoing cytoreductive surgery Eur. J. Med. Res. (IF 4.2) Pub Date : 2024-03-17 Mengna Zhao, Yang Gao, Junyuan Yang, Hao He, Min Su, Shimeng Wan, Xiaoye Feng, Hua Wang, Hongbing Cai
We aimed to evaluate the ability of Adult Comorbidity Evaluation 27 (ACE-27) to predict perioperative outcomes and survival in elderly women with advanced epithelial ovarian cancer (AEOC) undergoing cytoreductive surgery. We collected patients with AEOC in our hospital between January 1, 2012 and January 1, 2021. Patients younger than 65 years old or those with non-epithelial ovarian cancer were excluded
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CD4+ T cell count and HIV-1 viral load dynamics positively impacted by H. pylori infection in HIV-positive patients regardless of ART status in a high-burden setting Eur. J. Med. Res. (IF 4.2) Pub Date : 2024-03-17 Tesfay Abadi, Takele Teklu, Tadelo Wondmagegn, Meseret Alem, Girmay Desalegn
There is a widespread co-infection of HIV and Helicobacter pylori (H. pylori) globally, particularly in developing countries, and it has been suggested that this co-infection may affect the course of HIV disease. However, the interplay between H. pylori infection and HIV disease progression is not fully elucidated. In this study, we investigated the effect of H. pylori co-infection on CD4+ T cell count
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PDCL3 is a prognostic biomarker associated with immune infiltration in hepatocellular carcinoma Eur. J. Med. Res. (IF 4.2) Pub Date : 2024-03-17 Wenzhi Jin, Ganggang Wang, Meiyuan Dong, Xiaoliang Wang
Phosducin-like 3 (PDCL3) is a member of the photoreceptor family, characterized by a thioredoxin-like structural domain and evolutionary conservation. It plays roles in angiogenesis and apoptosis. Despite its significance, research on the biological role of PDCL3 in liver hepatocellular carcinoma (LIHC) remains limited. This study aims to explore the prognostic value and potential mechanisms of PDCL3
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Machine learning-driven prognostic analysis of cuproptosis and disulfidptosis-related lncRNAs in clear cell renal cell carcinoma: a step towards precision oncology Eur. J. Med. Res. (IF 4.2) Pub Date : 2024-03-16 Ronghui Chen, Jun Wu, Yinwei Che, Yuzhuo Jiao, Huashan Sun, Yinuo Zhao, Pingping Chen, Lingxin Meng, Tao Zhao
Cuproptosis and disulfidptosis, recently discovered mechanisms of cell death, have demonstrated that differential expression of key genes and long non-coding RNAs (lncRNAs) profoundly influences tumor development and affects their drug sensitivity. Clear cell renal cell carcinoma (ccRCC), the most common subtype of kidney cancer, presently lacks research utilizing cuproptosis and disulfidptosis-related
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A non-linear connection between the total cholesterol to high-density lipoprotein cholesterol ratio and stroke risk: a retrospective cohort study from the China Health and Retirement Longitudinal Study Eur. J. Med. Res. (IF 4.2) Pub Date : 2024-03-16 Binhui Xiao, Changchun Cao, Yong Han, Fangju Yang, Haofei Hu, Jiao Luo
The connection between total cholesterol to high-density lipoprotein cholesterol (TC/HDL-C) ratio and stroke risk is controversial. This study aims to examine the connection between the TC/HDL-C ratio and stroke in middle-aged and older individuals who are part of the China Health and Retirement Longitudinal Study (CHARLS). This study conducted a retrospective cohort analysis, enrolling a total of
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O-GlcNAcylation: a pro-survival response to acute stress in the cardiovascular and central nervous systems Eur. J. Med. Res. (IF 4.2) Pub Date : 2024-03-16 Qiu Xue, Shengtao Ji, Hui Xu, Shu Yu
O-GlcNAcylation is a unique monosaccharide modification that is ubiquitously present in numerous nucleoplasmic and mitochondrial proteins. The hexosamine biosynthesis pathway (HBP), which is a key branch of glycolysis, provides the unique sugar donor UDP-GlcNAc for the O-GlcNAc modification. Thus, HBP/O-GlcNAcylation can act as a nutrient sensor to perceive changes in nutrient levels and trigger O-GlcNAc
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Network pharmacology and molecular docking analysis on Shenfu Qiangxin indicate mTOR is a potential target to treat heart failure Eur. J. Med. Res. (IF 4.2) Pub Date : 2024-03-13 Peilin Zou, Jiajun Li, Yucong Zhang, Zonghao Qian, Hao Nie, Ni Yang, Le Zhang, Li Lin, Dewei Peng, Cuntai Zhang
Heart failure (HF) is one of the major causes of mortality worldwide with high recurrence rate and poor prognosis. Our study aimed to investigate potential mechanisms and drug targets of Shenfu Qiangxin (SFQX), a cardiotonic-diuretic traditional Chinese medicine, in treating HF. An HF-related and SFQX-targeted gene set was established using disease-gene databases and the Traditional Chinese Medicine
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A review of the current status and progress in difficult airway assessment research Eur. J. Med. Res. (IF 4.2) Pub Date : 2024-03-13 Haoming Chen, Yuqi Zheng, Qiang Fu, Peng Li
A difficult airway is a situation in which an anesthesiologist with more than 5 years of experience encounters difficulty with intubation or mask ventilation. According to the 2022 American Society of Anesthesiologists Practice Guidelines for the Management of Difficult Airway, difficult airways are subdivided into seven detailed categories. This condition can lead to serious adverse events and therefore
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Multiple sclerosis and personality traits: associations with depression and anxiety Eur. J. Med. Res. (IF 4.2) Pub Date : 2024-03-12 Saeed Vaheb, Yousef Mokary, Mohammad Yazdan Panah, Aysa Shaygannejad, Alireza Afshari-Safavi, Majid Ghasemi, Vahid Shaygannejad, Elham Moases Ghaffary, Omid Mirmosayyeb
Depression and anxiety are commonly observed in people with multiple sclerosis (pwMS). There is a growing body of literature supporting the hypothesis that personality traits can influence the mood disorders. This study aimed to investigate the personality traits and their relationships with depression and anxiety among pwMS. 234 pwMS were involved in this cross-sectional study. Personality traits
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Increasing the angle between caudal screw and the transverse plane may aggravate the risk of femoral head necrosis by deteriorating the fixation stability in patients with femoral neck fracture Eur. J. Med. Res. (IF 4.2) Pub Date : 2024-03-12 Jian Zhang, Shengyu Wan, Xiaozhong Luo, Caidong Zhang, Chao Wu, Lipeng He, Jingchi Li
Necrosis of the femoral head is the main complication in femoral neck fracture patients with triangle cannulated screw fixation. Instant postoperative fixation instability is a main reason for the higher risk of femoral head necrosis. Biomechanical studies have shown that cross screw fixation can effectively optimize fixation stability in patients with proximal humerus fractures and pedicle screw fixation
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Preparation of VX765 sodium alginate nanogels and evaluation of their therapeutic effect via local injection on myocardial infarction in rats Eur. J. Med. Res. (IF 4.2) Pub Date : 2024-03-12 Jianlong Liu, Qingxin Tian, Mingxiao Zhang
Myocardial Infarction (MI) is major cause of heart failure, highlighting the critical need for effective therapeutic strategies to improve cardiac repair. This study investigated the cardioprotective effects of VX765-coated polyethyleneimine (PEI)/sodium alginate (AG) composite nanogels (AG/PEI-VX765 NGs) in a rat model of MI. Additionally, AG-VX765 NGs and PEI-VX765 nanospheres (NPs) were synthesized
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Analysis of related factors for neuropsychiatric comorbidities in children with epilepsy Eur. J. Med. Res. (IF 4.2) Pub Date : 2024-03-12 Xin-Ying Zhang, Meng Sun, Jiang-Ya Wang, Fang-Fang Du, Xue-Fei Liu, Ling-Jun Wang, Zhen-De Hou, Ya-Ying Cheng
To analyze the risk factors affecting psychiatric behavior and study the psychobehavioral conditions of children with epilepsy. We randomly selected and enrolled 294 children with epilepsy who visited and were hospitalized in the pediatric clinic of Hebei General Hospital between January 2017 and January 2022, as the study participants. We comprehensively assessed their cognitive functions using the
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Effects of total gonadotropin dose on embryo quality and clinical outcomes with AMH stratification in IVF cycles: a retrospective analysis of 12,588 patients Eur. J. Med. Res. (IF 4.2) Pub Date : 2024-03-12 Xiaoxue Shen, Yuhan Guo, Yan Liu, Wenyan Song, Gang Li, Haixia Jin
Recent studies about the effect of gonadotropin (Gn) dose on the clinical outcomes of IVF are still controversial, and no studies have analyzed the relationship between Gn dose and embryo quality. Since AMH is a strong predictor of oocyte quality, we aim to evaluate the relationship between total Gn dose and embryo quality and clinical outcomes at different AMH levels in IVF cycles. A total of 12,588
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Identification of the prognostic value of LACTB2 and its correlation with immune infiltrates in ovarian cancer by integrated bioinformatics analyses Eur. J. Med. Res. (IF 4.2) Pub Date : 2024-03-12 Weiwei Cao, Chao Wang, Yue Zhang, Jiani Yang, Xiaomei Luo, Yaqian Zhao, Meixuan Wu, Shanshan Cheng, Yu Wang
Ovarian cancer (OC) is one of the most common reproductive tumors in women, whereas current treatment options are limited. β-lactamase-like-protein 2 (LACTB2) has been observed to be associated with various cancers, but its function in OC is unknown. Therefore, we evaluate the prognostic value and the underlying function of LACTB2 in OC. In this study, high expression of LACTB2 was observed in OC compared
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Association between 3D membranous urethral parameters and urinary continence recovery after RARP Eur. J. Med. Res. (IF 4.2) Pub Date : 2024-03-12 Ming Wang, Ruiqi Deng, Lei Wang, Mingzhao Li, Tao Zeng, Yanqun Na, Di Gu
To evaluate whether the urinary continence (UC) recovery after robotic-assisted radical prostatectomy (RARP) relates to the membranous urethral length (MUL) and the membranous urethral complex volume (MUV). 120 patients who underwent RARP were enrolled according to the different times of UC recovery and examined using prostate magnetic resonance imaging (MRI) before surgery. The membranous urethral
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Treatment modalities for granulomatous mastitis, seeking the most appropriate treatment with the least recurrence rate: a systematic review and meta-analysis Eur. J. Med. Res. (IF 4.2) Pub Date : 2024-03-12 Roham Sarmadian, Fatemeh Safi, Hossein Sarmadian, Maryam Shokrpour, Amir Almasi-Hashiani
Granulomatous mastitis (GM) is a rare, benign, inflammatory breast disease with an unknown etiology that predominantly affects women of reproductive age. The definitive treatment of GM is currently controversial; an appropriate therapeutic strategy has yet to be identified, and the disease’s high recurrence rate remains. This study aims to determine the recurrence rate for each GM treatment strategy
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Current evidence regarding alternative techniques for enterocystoplasty using regenerative medicine methods: a systematic review Eur. J. Med. Res. (IF 4.2) Pub Date : 2024-03-12 Razman Arabzadeh Bahri, Maral Peisepar, Saba Maleki, Fatemeh Esmaeilpur Abianeh, Fatemeh A. Basti, Ali Kolahdooz
Enterocystoplasty is the most commonly used treatment for bladder reconstruction. However, it has some major complications. In this study, we systematically reviewed the alternative techniques for enterocystoplasty using different scaffolds. A comprehensive search was conducted in PubMed, Embase, and Cochrane Library, and a total of 10 studies were included in this study. Five different scaffolds were
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Neutrophil lncRNA ZNF100-6:2 is a potential diagnostic marker for active pulmonary tuberculosis Eur. J. Med. Res. (IF 4.2) Pub Date : 2024-03-12 Shuying Huang, Xiuhua Kang, Zhenguo Zeng, Qilong Zhang, Zikun Huang, Kaihang Luo, Qinqin Yao, Bing Chen, Cheng Qing
Active pulmonary tuberculosis (PTB) poses challenges in rapid diagnosis within complex clinical conditions. Given the close association between neutrophils and tuberculosis, we explored differentially expressed long non-coding RNAs (lncRNAs) in neutrophils as potential molecular markers for diagnosing active PTB. We employed a gene microarray to screen for lncRNA alterations in neutrophil samples from
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Univariable and multivariable Mendelian randomization study identified the key role of gut microbiota in immunotherapeutic toxicity Eur. J. Med. Res. (IF 4.2) Pub Date : 2024-03-12 Baike Liu, Zheran Liu, Tianxiang Jiang, Xiangshuai Gu, Xiaonan Yin, Zhaolun Cai, Xiaoqiao Zou, Lei Dai, Bo Zhang
In cancer patients receiving immune checkpoint inhibitors (ICIs), there is emerging evidence suggesting a correlation between gut microbiota and immune-related adverse events (irAEs). However, the exact roles of gut microbiota and the causal associations are yet to be clarified. To investigate this, we first conducted a univariable bi-directional two-sample Mendelian randomization (MR) analysis. Instrumental
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An increase in SNHG5 expression is associated with poor cancer prognosis, according to a meta-analysis Eur. J. Med. Res. (IF 4.2) Pub Date : 2024-03-12 Qiang Huang, Yi-gui Xia, Yong-jian Huang, Hai-feng Qin, Qun-xian Zhang, Chun-feng Wei, Wu-ru Tang, Yuan Liao
He long noncoding RNA small nucleolar host RNA 5 (SNHG5) is highly expressed in many cancers, and there is a notable correlation between the elevated expression of SNHG5 and survival outcome in cancer patients. The objective of this study was to conduct a meta-analysis to evaluate the correlation between SNHG5 expression and the clinical outcome of cancer patients. Six relevant electronic databases
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Hypoxia-induced circRNAs encoded by PPARA are highly expressed in human cardiomyocytes and are potential clinical biomarkers of acute myocardial infarction Eur. J. Med. Res. (IF 4.2) Pub Date : 2024-03-12 Shasha Huang, Zhangying Wu, Yang Zhou
Acute myocardial infarction (AMI) is a serious cardiovascular disease that adversely affects human health. Circular RNAs (circRNAs) are involved in the pathological and physiological processes of AMI, but the biological mechanism of their involvement and their clinical significance remain unknown. We aimed to identify circRNAs that are significantly associated with morbidity in the peripheral blood
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Correction: Evaluating safety risks of whole-body cryotherapy/cryostimulation (WBC): a scoping review from an international consortium Eur. J. Med. Res. (IF 4.2) Pub Date : 2024-03-12 Fabien D. Legrand, Benoit Dugue, Joe Costello, Chris Bleakley, Elzbieta Miller, James R. Broatch, Guillaume Polidori, Anna Lubkowska, Julien Louis, Giovanni Lombardi, Francois Bieuzen, Paolo Capodaglio
Correction: European Journal of Medical Research (2023) 28:387 https://doi.org/10.1186/s40001-023-01385-z In the original publication of the article [1], the affiliation details of the authors, Giovanni Lombardi and Paolo Capodaglio were incorrectly given as “Laboratory of Experimental Biochemistry, IRCCS Istituto Ortopedico Galeazzi, 20157 Milan, Italy” and “Laboratorio di Ricerca in Biomeccanica
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Comparative analysis of the vaginal bacteriome and virome in healthy women living in high-altitude and sea-level areas Eur. J. Med. Res. (IF 4.2) Pub Date : 2024-03-07 Chaoran Li, Song jin, Oingbo Lv, Guangyang Wang, Yue Zhang, Shenghui Li, Wei zhang, Fang Long, Zhuowei Shen, Siqi Bai, Duoii Zhaxi, Fandou Kong, Qiulong Yan, Zhen Xiao
The vaginal microbiota plays an important role in the health of the female reproductive tract and is closely associated with various pregnancy outcomes and sexually transmitted diseases. Plenty of internal and external factors have strong influence on the changes in a woman's vaginal microbiome. However, the effect of a high-altitude on female vaginal microbiota has not been described. In this study
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Predicting sepsis in-hospital mortality with machine learning: a multi-center study using clinical and inflammatory biomarkers Eur. J. Med. Res. (IF 4.2) Pub Date : 2024-03-06 Guyu Zhang, Fei Shao, Wei Yuan, Junyuan Wu, Xuan Qi, Jie Gao, Rui Shao, Ziren Tang, Tao Wang
This study aimed to develop and validate an interpretable machine-learning model that utilizes clinical features and inflammatory biomarkers to predict the risk of in-hospital mortality in critically ill patients suffering from sepsis. We enrolled all patients diagnosed with sepsis in the Medical Information Mart for Intensive Care IV (MIMIC-IV, v.2.0), eICU Collaborative Research Care (eICU-CRD 2
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Tibial cortex transverse transport promotes ischemic diabetic foot ulcer healing via enhanced angiogenesis and inflammation modulation in a novel rat model Eur. J. Med. Res. (IF 4.2) Pub Date : 2024-03-06 Wencong Qin, Kaibin Liu, Hongjie Su, Jun Hou, Shenghui Yang, Kaixiang Pan, Sijie Yang, Jie Liu, Peilin Zhou, Zhanming Lin, Puxiang Zhen, Yongjun Mo, Binguang Fan, Zhenghui Li, Xiaocong Kuang, Xinyu Nie, Qikai Hua
Tibial Cortex Transverse Transport (TTT) represents an innovative surgical method for treating lower extremity diabetic foot ulcers (DFUs), yet its underlying mechanisms remain elusive. Establishing an animal model that closely mirrors clinical scenarios is both critical and novel for elucidating the mechanisms of TTT. We established a diabetic rat model with induced hindlimb ischemia to mimic the
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CD133 significance in glioblastoma development: in silico and in vitro study Eur. J. Med. Res. (IF 4.2) Pub Date : 2024-03-06 Mahdi Abdoli Shadbad, Fatemeh Nejadi Orang, Behzad Baradaran
Glioblastoma multiform (GBM) is among the commonly diagnosed brain malignancies with poor prognosis. CD133 has been introduced as an oncogene in various cancers, like GBM. This study aimed to investigate the significance of CD133 in GBM development using in silico and in vitro techniques. The TCGA-GBM database was analyzed for the correlational and comparative studies. After selecting the U87MG cell
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Torso hemorrhage: noncompressible? never say never Eur. J. Med. Res. (IF 4.2) Pub Date : 2024-03-06 Lian-Yang Zhang, Hua-Yu Zhang
Since limb bleeding has been well managed by extremity tourniquets, the management of exsanguinating torso hemorrhage (TH) has become a hot issue both in military and civilian medicine. Conventional hemostatic techniques are ineffective for managing traumatic bleeding of organs and vessels within the torso due to the anatomical features. The designation of noncompressible torso hemorrhage (NCTH) marks
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Advances in secondary prevention mechanisms of macrovascular complications in type 2 diabetes mellitus patients: a comprehensive review Eur. J. Med. Res. (IF 4.2) Pub Date : 2024-03-04 Huifang Guan, Jiaxing Tian, Ying Wang, Ping Niu, Yuxin Zhang, Yanjiao Zhang, Xinyi Fang, Runyu Miao, Ruiyang Yin, Xiaolin Tong
Type 2 diabetes mellitus (T2DM) poses a significant global health burden. This is particularly due to its macrovascular complications, such as coronary artery disease, peripheral vascular disease, and cerebrovascular disease, which have emerged as leading contributors to morbidity and mortality. This review comprehensively explores the pathophysiological mechanisms underlying these complications, protective
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TR4 worsen urosepsis by regulating GSDMD Eur. J. Med. Res. (IF 4.2) Pub Date : 2024-03-01 Huan Wang, Shibin Zhu, Zhenwei Zhou, Zhenghui Wang, Wei Zhuang, Dingwei Xue, Zeyi Lu, Qiming Zheng, Lifeng Ding, Liangliang Ren, Wenqing Luo, Ruyue Wang, Guangju Ge, Liqun Xia, Gonghui Li, Haiyang Wu
Urosepsis is a life-threatening organ disease in which pathogenic microorganisms in the urine enter the blood through the vessels, causing an imbalance in the immune response to infection. The aim of this study was to elucidate the role of testicular orphan receptor 4 (TR4) in urosepsis. The role of TR4 in the progression and prognosis of urosepsis was confirmed by analyzing data from online databases
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Ultrasound findings and specific intrinsic blood volume expansion therapy for neonatal capillary leak syndrome: report from a multicenter prospective self-control study Eur. J. Med. Res. (IF 4.2) Pub Date : 2024-03-01 Jing Liu, Yue-Qiao Gao, Wei Fu
Capillary leak syndrome (CLS) is characterized by severe systemic edema without specific treatment, resulting in a high mortality rate. This study investigated whether there is organ edema in neonatal CLS patients and specific treatment strategies to improve patient prognosis. Thirty-seven newborns diagnosed with CLS were included in this study. (1) Routine point-of-care ultrasound (POCUS) was used
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Study on the effect and mechanism of Zhenzhu Tongluo pills in treating diabetic peripheral neuropathy injury Eur. J. Med. Res. (IF 4.2) Pub Date : 2024-03-01 Pengfei Dong, Lin Zhou, Xiaohui Wang, Lianping Xue, Yang Du, Rui Cui
As a traditional Mongolian medicine, Zhenzhu Tongluo pills has played a good neuroprotective function in clinic. However, the key mechanisms by which it works are poorly studied. To study the effect and mechanism of Zhenzhu Tongluo pills in treating diabetic peripheral neuropathy injury. Diabetic peripheral neuropathy model was established by injecting STZ into rats. Physiological, behavioral, morphological
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Clinical evidence of the link between gut microbiome and myalgic encephalomyelitis/chronic fatigue syndrome: a retrospective review Eur. J. Med. Res. (IF 4.2) Pub Date : 2024-03-01 Jing-Hua Wang, Yujin Choi, Jin-Seok Lee, Seung-Ju Hwang, Jiyeon Gu, Chang-Gue Son
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a heterogeneous disorder with elusive causes, but most likely because of clinical and other biological factors. As a vital environmental factor, the gut microbiome is increasingly emphasized in various refractory diseases including ME/CFS. The present study is aimed to enhance our understanding of the relationship between the gut microbiome
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Changes of Mycobacterium tuberculosis specific antigen-stimulated CD27−CD38+IFN-γ+CD4+ T cells before and after anti-tuberculosis treatment Eur. J. Med. Res. (IF 4.2) Pub Date : 2024-03-01 Yong Fang, Yuan Tang, Qiao-Xia Luo, Na Wang, Liang Tang, Xiao-Jun Yang, Xiao-Fang You, Yu-Chun Wang, Li Liang, Jing-Bo Zhang, Bo Su, Wei Sha
The aim of the study was to investigate whether the expression of CD27−CD38+ in interferon (IFN)-γ+CD4+ T cells stimulated by the specific antigen early secreted antigenic target-6 (ESAT-6)/culture filter protein-10 (CFP-10) could be a potential new therapeutic evaluation indicator for anti-tuberculosis (TB) treatment. Newly diagnosed active pulmonary TB patients, latent TB infection (LTBI) and healthy
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Serum proteome analysis identifies a potential biomarker for axial psoriatic arthritis Eur. J. Med. Res. (IF 4.2) Pub Date : 2024-03-01 Chaofan Lu, Fan Yang, Shihao He, Hongxia Yu, Qian Wang, Mengtao Li, Xiaofeng Zeng, Xiaomei Leng
To identify potential serum biomarkers for differentiating between axial psoriatic arthritis (axPsA) and peripheral psoriatic arthritis (pPsA). Serum samples were collected from patients with PsA to create a biomarker discovery cohort and a verification cohort. Patients with PsA were classified into axial or peripheral subtypes based on imaging criteria. Untargeted proteomics technology was used in
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Systemic immune-inflammation index and in-stent restenosis in patients with acute coronary syndrome: a single-center retrospective study Eur. J. Med. Res. (IF 4.2) Pub Date : 2024-02-26 Feng Xie, Zuozhong Yu, Yurong Xiong, Zhijian Wu, Yanqing Wu
In-stent restenosis (ISR) has been shown to be correlated with inflammation. This study aimed to examine the relationship between systemic immune-inflammation index (SII, an innovative inflammatory biomarker) and ISR in acute coronary syndrome (ACS) patients after drug-eluting stent (DES) implantation. Subjects who were diagnosed with ACS and underwent DES implantation were enrolled retrospectively
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Clinical characteristics and outcomes of patients who underwent neonatal cardiac surgery: ten years of experience in a tertiary surgery center Eur. J. Med. Res. (IF 4.2) Pub Date : 2024-02-26 Han Zhang, Gang Li, Qiangqiang Li, Yansong Zuo, Qiang Wang
To evaluate the outcomes after neonatal cardiac surgery at our institute, and identify factors associated with operative mortality. We examined 224 neonates who underwent cardiac surgery at a single institution from 2013 to 2022. Relevant data, such as demographic information, operative details, and postoperative records, were gathered from medical and surgical records. Our primary focus was on the
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Unraveling the causality between chronic obstructive pulmonary disease and its common comorbidities using bidirectional Mendelian randomization Eur. J. Med. Res. (IF 4.2) Pub Date : 2024-02-26 Zihan Wang, Yongchang Sun
Chronic obstructive pulmonary disease (COPD) frequently coexists with various diseases, yet the causal relationship between COPD and these comorbidities remains ambiguous. As a result, the aim of our study is to elucidate the potential causality between COPD and its common comorbidities. We employed the Mendelian randomization (MR) method to analyze single nucleotide polymorphism (SNP) data of common
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Effect of capsular tension ring on the refractive outcomes of patients with extreme high axial myopia after phacoemulsification Eur. J. Med. Res. (IF 4.2) Pub Date : 2024-02-24 Hui-Ying Zhao, Jing-Shang Zhang, Meng Li, Dong-Jun Chen, Xiu-Hua Wan
The aim of the study is to evaluate the effect of capsular tension ring (CTR) implantation following cataract surgery on the refractive outcomes of patients with extreme high axial myopia. Sixty eyes (with an axial length of ≥26 mm) were retrospectively reviewed and classified into two groups: CTR group (n = 30), which underwent CTR implantation following phacoemulsification, and control group (n = 30)
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Polyvascular atherosclerosis and renal dysfunction increase the odds of cognitive impairment in vascular disease: findings of the LipidCardio study Eur. J. Med. Res. (IF 4.2) Pub Date : 2024-02-22 Maximilian König, Katie Palmer, Carolin Malsch, Elisabeth Steinhagen-Thiessen, Ilja Demuth
Growing evidence suggests a causal role for atherosclerotic vascular disease in cognitive impairment and dementia. Atherosclerosis may present as monovascular disease (monoVD) or as widespread polyvascular atherosclerotic disease (polyVD). Evidence on the relationship between monoVD or polyVD and cognitive impairment is limited. We conducted a cross-sectional analysis of baseline data from the LipidCardio
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Association between estimated glomerular filtration rate and reversion to normoglycemia in people with impaired fasting glucose: a 5-year retrospective cohort study Eur. J. Med. Res. (IF 4.2) Pub Date : 2024-02-22 Lirong Tu, Haofei Hu, Xinglei Zhou, Heping Zhang, Xiaohui Liu, Dehua Yang, Yongcheng He
The present body of evidence regarding the correlation between the estimated glomerular filtration rate (eGFR) and the reversal of impaired fasting glucose (IFG) to normoglycemia remains constrained. Consequently, the objective of our study is to examine the relationship between eGFR and the restoration of normoglycemia in individuals with IFG. This retrospective cohort study consecutively collected
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Correction: The effect of frontal trauma on the edentulous mandible with four different interforaminal implant-prosthodontic anchoring configurations. A 3D finite element analysis Eur. J. Med. Res. (IF 4.2) Pub Date : 2024-02-21 Stefan Krennmair, Michael Malek, Raphael Stehrer, Philip Stähler, Sven Otto, Lukas Postl
Correction: European Journal of Medical Research (2023) 28:608 https://doi.org/10.1186/s40001-023-01580-y In the original version of this article [1], the given and family names of all the authors except "Philip Stähler" were swapped incorrectly. The corrected given and family names of the authors should read as "Stefan Krennmair, Michael Malek, Raphael Stehrer, Philip Stähler, Sven Otto and Lukas
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Analysis of relevant factors influencing size of breast abscess cavity during lactation: a cross-sectional study Eur. J. Med. Res. (IF 4.2) Pub Date : 2024-02-20 Gao Yajun, Zou Yan, Zhang Yi, Chen si, Li yan, Ding Songtao
The aim of this study was to investigate risk factors for the severity of breast abscess during lactation. A cross-sectional study was conducted using data from the Questionnaire survey of breast abscess patients. According to whether the maximum abscess diameter > 5 cm, the patients were divided into two groups for univariate and multivariate regression analysis. 1805 valid questionnaires were included
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Incremental values of AOPP, IL-6, and GDF15 for identifying arteriosclerosis in patients with obstructive sleep apnea Eur. J. Med. Res. (IF 4.2) Pub Date : 2024-02-20 Xinxin Li, Wen Liu, Yonghuai Wang, Cuiting Zhao, Qing Zhu, Zhishuang Dong, Chunyan Ma
The objective of this study was to determine the independent and incremental values of advanced oxidative protein product (AOPP), interleukin 6 (IL-6), and growth differentiation factor 15 (GDF15) in identifying arteriosclerosis in patients with obstructive sleep apnea (OSA). A total of 104 individuals diagnosed with OSA by polysomnography were recruited in our study. Arteriosclerosis was defined by
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Langerhans cell histiocytosis of the skull in 23 children Eur. J. Med. Res. (IF 4.2) Pub Date : 2024-02-17 Min Wei, Wenbin Jiang, Rui Wang, Bo Xiao, Qijia Zhan
To explore the clinical features, diagnosis, treatment and prognosis of Langerhans cell histiocytosis (LCH) of the skull in children. This study retrospectively summarized the clinical manifestations, treatment methods and follow-up status of children with skull LCH who were admitted to the Department of Neurosurgery of Shanghai Children’s Hospital from January 2014 to June 2021. A total of 23 patients
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Association of triglyceride glucose index with cardiovascular events: insights from the Isfahan Cohort Study (ICS) Eur. J. Med. Res. (IF 4.2) Pub Date : 2024-02-17 Hamed Rafiee, Noushin Mohammadifard, Fatemeh Nouri, Ghazaal Alavi Tabatabaei, Jamshid Najafian, Masoumeh Sadeghi, Maryam Boshtam, Hamidreza Roohafza, Fahimeh Haghighatdoost, Razieh Hassannejad, Nizal Sarrafzadegan
There is limited evidence regarding the evaluation of the association between the triglyceride glucose (TyG) index, an indicator of insulin resistance, and the incident risk of cardiovascular disease (CVD). Therefore, we aimed to examine the relationship between the TyG index and CVD incidence in a cohort of Iranian adults. This study was performed in the framework of the Isfahan Cohort Study (ICS)
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Long noncoding RNA and messenger RNA profiling in epicardial adipose tissue of patients with new-onset postoperative atrial fibrillation after coronary artery bypass grafting Eur. J. Med. Res. (IF 4.2) Pub Date : 2024-02-17 Yuanshu Peng, Pixiong Su, Lei Zhao
Postoperative atrial fibrillation (POAF) constitutes a significant complication following coronary artery bypass graft surgery (CABG), potentially linked to epicardial adipose tissue (EAT). This investigation seeks to elucidate the association between POAF and EAT at the genetic level. EAT and clinical data from patients undergoing CABG were systematically acquired, adhering to established inclusion
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Reliability, stability during long-term storage, and intra-individual variation of circulating levels of osteopontin, osteoprotegerin, vascular endothelial growth factor-A, and interleukin-17A Eur. J. Med. Res. (IF 4.2) Pub Date : 2024-02-17 Tomoki Nakamizo, John Cologne, Takeshi Kishi, Tetsuya Takahashi, Mayumi Inoue, Hiroyuki Ryukaku, Tomonori Hayashi, Yoichiro Kusunoki, Saeko Fujiwara, Waka Ohishi
Studies in many populations have reported associations between circulating cytokine levels and various physiological or pathological conditions. However, the reliability of cytokine measurements in population studies, which measure cytokines in multiple assays over a prolonged period, has not been adequately examined; nor has stability during sample storage or intra-individual variation been assessed
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A rare inflammatory myofibroblastic tumor appearing both inside and outside the heart Eur. J. Med. Res. (IF 4.2) Pub Date : 2024-02-17 Jiarong Li, Jijia Liu, Xingwang Yao, Jinfu Yang
Inflammatory myofibroblastic tumor (IMT) is an uncommon cardiac tumor that primarily affects infants, children, and young adults. While complete surgical resection generally leads to a favorable prognosis, accurate diagnostic tests remain limited. We describe the case of a 26-year-old female who had a dual tumor inside and outside the heart and was misdiagnosed by echocardiography and MRI. We also
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Concentration strategies for spiked and naturally present biomarkers in non-invasively collected first-void urine Eur. J. Med. Res. (IF 4.2) Pub Date : 2024-02-17 Laura Téblick, Marijana Lipovac, F. Ricardo Burdier, Annemie De Smet, Margo Bell, Eef van den Borst, Veerle Matheeussen, Alex Vorsters
First-void urine (FVU) provides a non-invasive method for collecting a wide range of biomarkers found in genital tract secretions. To optimize biomarker collection in FVU, this study investigated the impact of naturally present and supplemented precipitating agents: uromodulin (UMOD) and polyethylene glycol (PEG), on the concentration of human papillomavirus (HPV) pseudovirions (PsV), cell-free DNA
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Enhancing tube feeding method for neurosurgery: the application of improved PICC technique Eur. J. Med. Res. (IF 4.2) Pub Date : 2024-02-17 Huiwen Wu, Yuru Qiu, Yucui Wang, Jiarong Li, Yihong Qiu
Peripherally inserted central catheter (PICC) used in neurosurgical patients requires changes in patients' head positions. However, such changes can worsen pressure on the brain tissue, lead to sudden acute brain herniation and respiratory arrest, resulting in a higher chance of patient death. This paper addresses the aforementioned problems by introducing a new PICC catheterization method. In a retrospective
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The optimal blood glucose is significantly associated with lower mortality in critically ill patients with cardiogenic shock: an analysis revealed with time series blood glucose records Eur. J. Med. Res. (IF 4.2) Pub Date : 2024-02-17 Ce Sun, Ji-Hong Zhou, Yan-Ling Huang, Yi-Le Ning, Xiang-Hui Xu
The optimal blood glucose (BG) level for patients with cardiogenic shock in the intensive care unit (ICU) remains unclear. Studies have found that both excessively high and low BG levels contribute to adverse cardiovascular events. Our study aims to investigate the optimal BG level for critically ill patients with cardiogenic shock and evaluate the effects of optimal BG on the prognosis of patients
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Follow-up outcome analysis of 324 cases of early-onset and late-onset mild fetal ventriculomegaly: a retrospective cohort study Eur. J. Med. Res. (IF 4.2) Pub Date : 2024-02-16 Xuemei Wang, Shanlong Zhang, Jingjing Wang, Simin Zhang, Li Feng, Qingqing Wu
Mild fetal ventriculomegaly (VM) is a nonspecific finding common to several pathologies with varying prognosis and is, therefore, a challenge in fetal consultation. We aimed to perform a constant, detailed analysis of prenatal findings and postnatal outcomes in fetuses with early-onset and late-onset mild ventriculomegaly, and provide a new evidence basis and new perspective for prenatal counseling
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The impact of the first and the second wave of the COVID-19 pandemic on vascular surgery practice in the leading regional center: a comparative, retrospective study Eur. J. Med. Res. (IF 4.2) Pub Date : 2024-02-16 Katarzyna Stadnik-Zawalska, Julia Tomys-Składowska, Patryk Zawalski, Krzysztof Buczkowski, Arkadiusz Migdalski
We conducted an analysis of the vascular surgery regional center reorganization in response to the first and the second wave of the coronavirus disease-2019 (COVID-19) pandemic to see what lessons we learned from the first wave. The study included a total of 632 patients admitted to the vascular surgery department in three periods: March–May 2020, October–December 2020, and October–December 2019 as
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Dual-energy computed tomography in the early evaluation of acute radiation pneumonia Eur. J. Med. Res. (IF 4.2) Pub Date : 2024-02-16 Zong-Sheng Wang, Jing Wu, Gang Yuan, Yong-Bao Liu, Xiao-Ping He
To investigate the value of dual-energy dual-source computed tomography (DSCT) in evaluating pulmonary perfusion changes before and after radiotherapy for esophageal cancer, and its clinical use in the early diagnosis of acute radiation pneumonia (ARP). We selected 45 patients with pathologically confirmed esophageal cancer who received radiotherapy (total irradiation dose of 60 Gy). Dual-energy DSCT
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Investigating the efficacy of vacuum sealing drainage versus traditional negative pressure drainage in treating deep incision infections following posterior cervical internal fixation—a retrospective cohort study Eur. J. Med. Res. (IF 4.2) Pub Date : 2024-02-15 Jianhua Li, Dawei Jiang, Zhengqi Chang
Assessing the efficacy and safety of Vacuum Sealing Drainage (VSD) in treating deep incision infections (DII) following posterior cervical internal fixation. We retrospectively studied the clinical effects of VSD and Traditional Negative Pressure Drainage (TND) on 12 patients with deep incision infection after posterior cervical fixation surgery who were treated in our department from 2012 to 2020
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The paradoxical role of cytokines and chemokines at the tumor microenvironment: a comprehensive review Eur. J. Med. Res. (IF 4.2) Pub Date : 2024-02-15 Toufik Abdul-Rahman, Shankhaneel Ghosh, Sarah M. Badar, Abubakar Nazir, Gafar Babatunde Bamigbade, Narjiss Aji, Poulami Roy, Hajar kachani, Neil Garg, Lukman Lawal, Zarah Sophia Blake Bliss, Andrew Awuah Wireko, Oday Atallah, Favour Tope Adebusoye, Tetiana Teslyk, Kateryna Sikora, Viktoriia Horbas
Tumor progression and eradication have long piqued the scientific community's interest. Recent discoveries about the role of chemokines and cytokines in these processes have fueled renewed interest in related research. These roles are frequently viewed as contentious due to their ability to both suppress and promote cancer progression. As a result, this review critically appraised existing literature
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New score to predict COVID-19 progression in vaccine and early treatment era: the COVID-19 Sardinian Progression Score (CSPS) Eur. J. Med. Res. (IF 4.2) Pub Date : 2024-02-15 Andrea De Vito, Laura Saderi, Agnese Colpani, Mariangela V. Puci, Beatrice Zauli, Vito Fiore, Marco Fois, Maria Chiara Meloni, Alessandra Bitti, Giulia Moi, Ivana Maida, Sergio Babudieri, Giovanni Sotgiu, Giordano Madeddu
Several scores aimed at predicting COVID-19 progression have been proposed. As the variables vaccination and early SARS-CoV-2 treatment were systematically excluded from the prognostic scores, the present study's objective was to develop a new model adapted to the current epidemiological scenario. We included all patients evaluated by the Infectious Disease Unit in Sassari, with SARS-CoV-2 infection
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Factors affecting the length of hospital stay for total knee arthroplasty in Japan: a retrospective study using the diagnosis procedure combination database Eur. J. Med. Res. (IF 4.2) Pub Date : 2024-02-14 Kentaro Hara, Masato Kanda, Yoshio Kobayashi, Takashi Miyamoto, Takahiro Inoue
We aimed to evaluate the length of hospital stay following total knee arthroplasty to determine the impact of relevant factors using data from the Diagnosis Procedure Combination database. This was a retrospective observational study. The study cohort included 5,831 patients who had osteoarthritis of the knee and had undergone total knee replacement between February 2018 and October 2022 at 38 hospitals