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Distribution of cup-disc ratio in a Swedish population. Ups. J. Med. Sci. (IF 3.4) Pub Date : 2023-10-13 Edvin Svedberg,Curt Ekström
Background Increased cup-disc ratio (CDR) is a hallmark of open-angle glaucoma (OAG), an age-related neurodegenerative disease of significant importance for public health. There are few studies on the distribution of CDR in the Nordic populations. Methods The distribution of CDR was studied in 749 subjects aged 65-74 years in a population survey in the rural district of Tierp, Sweden, from 1984 to
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Persistent SARS-CoV-2 infection in patients with B-cell deficiency: a case series of successful antiviral treatment of four patients. Ups. J. Med. Sci. (IF 3.4) Pub Date : 2023-10-11 Lisa Faxén,Marie Edvinsson
Persistent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in immunocompromised patients remains a major medical challenge. Diagnosing the syndrome is difficult as symptoms may mimic other diseases and treatment guidelines are lacking. We describe a case series of four patients with persistent SARS-CoV-2 infection that all had an underlying B-cell deficiency due to rituximab
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Associations of spleen volume with markers of blood count and lipid profile in a large population-based study. Ups. J. Med. Sci. (IF 3.4) Pub Date : 2023-09-15 Muhammad Naeem,Till Ittermann,Marcello Ricardo Paulista Markus,Mohammed Farah Mahmoud Mousa,Laura von Heder,Robin Bülow,Marcus Dörr,Matthias Nauck,Ali Agdassi,Florian H Heidel,Henry Völzke
Background The aim of our study was to investigate associations of spleen volume with blood count markers and lipid profile in the general population. Materials & methods Cross-sectional data from 1,106 individuals aged 30-90 years from the population-based Study of Health in Pomerania (SHIP-START-2) were analyzed. Blood count markers included red blood cell (RBC) counts, hemoglobin, platelet count
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Stand-alone virtual reality exposure therapy as a treatment for social anxiety symptoms: a systematic review and meta-analysis. Ups. J. Med. Sci. (IF 3.4) Pub Date : 2023-09-14 Christian Rejbrand,Brynjar Fure,Karin Sonnby
Introduction Social anxiety is common and can have far-reaching implications for affected individuals, both on social life and working performance. Usage of virtual reality exposure therapy (VRET) has gained traction. The aim of the present systematic review was to evaluate the effect of stand-alone VRET on social anxiety symptoms. Method We searched systematically in PubMed, Embase, PSYCinfo, and
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A long-term follow-up study of labor market marginalization in psychiatric patients with and without personality disorder. Ups. J. Med. Sci. (IF 3.4) Pub Date : 2023-07-31 Hanna Spangenberg,Mia Ramklint,Adriana Ramirez
Background Personality disorders (PDs) in adulthood are considered stable over time and are likely to have lasting psychosocial impact on the affected individual, including in areas like vocational functioning. The aim of this study was to study labor market marginalization (LMM) and receipt of social welfare benefits during 13 years from age 18 to 25 years in a sample of former psychiatric patients
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Maternal, pregnancy and neonatal outcomes in triplet pregnancies in Sweden - a nationwide cohort study. Ups. J. Med. Sci. (IF 3.4) Pub Date : 2023-07-17 Mia-Maria Ekström,Eleonor Tiblad,Mikael Norman,Olof Stephansson,Michaela Granfors
Background Triplet pregnancies carry a high risk of pregnancy-related complications. The primary aim of this study was to describe maternal, pregnancy, and neonatal outcomes in expectantly managed triplet pregnancies in Sweden. The secondary aim was to compare outcomes in expectantly managed triplet pregnancies with triplet pregnancies where fetal reduction had been performed with the only indication
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Accuracy of a faecal immunochemical test in patients under colonoscopy surveillance of colorectal adenoma and cancer. Ups. J. Med. Sci. (IF 3.4) Pub Date : 2023-06-23 Louise Olsson,Daniel Sjöberg
Background Surveillance of colorectal neoplasia place great strain on colonoscopy resources, and faecal immunochemical tests (FIT) are under-investigated for this purpose. The aim of this study was to report the outcome of FIT among patients scheduled for post-polypectomy and post-resection colorectal cancer (CRC) surveillance. Methods Patients scheduled for colonoscopy surveillance at five endoscopy
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Validation of myocarditis diagnoses in the Swedish patient register for analyses of potential adverse reactions to COVID-19 vaccines. Ups. J. Med. Sci. (IF 3.4) Pub Date : 2023-05-11 Rolf Gedeborg,Lennart Holm,Nils Feltelius,Anders Sundström,Kai M Eggers,Marja-Leena Nurminen,Maria Grünewald,Nicklas Pihlström,Björn Zethelius,Rickard Ljung
Background Coronavirus disease 2019 (COVID-19) mRNA vaccines are associated with an increased risk of myocarditis using hospital discharge diagnoses as an outcome. The validity of these register-based diagnoses is uncertain. Methods Patient records for subjects < 40 years of age and a diagnosis of myocarditis in the Swedish National Patient Register were manually reviewed. Brighton Collaboration diagnosis
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Increased plasma endostatin and GDF15 in indolent non-Hodgkin lymphoma. Ups. J. Med. Sci. (IF 3.4) Pub Date : 2023-05-09 Josefin Hidman,Anders Larsson,Måns Thulin,Torbjörn Karlsson
Background Increased microvascular density correlates with more advanced disease and unfavorable overall survival in non-Hodgkin lymphoma (NHL), suggesting that angiogenesis is important for disease progression. However, studies of anti-angiogenic agents in NHL patients, have generally not shown favorable outcomes. The aim of this study was to investigate whether plasma levels of a subset of angiogenesis-associated
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Assessing stress using repeated saliva concentration of steroid hormones in dementia care dyads: results from a controlled pilot care music intervention. Ups. J. Med. Sci. (IF 3.4) Pub Date : 2023-05-05 Azita Emami,Töres Theorell,Hyejin Kim,Lars Berglund,Helena Hallinder,Gabriella Engström
Background Stress-related biomarkers have the potential to provide objective measures of whether interventions directed at people with dementia (PWD) and their family caregivers (FCG) are successful. The use of such biomarkers has been limited by logistical barriers to sample collection. Objective Explore saliva concentration of steroid hormones in dementia care dyads during a music intervention. Methods
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Association of physiological stress markers at the emergency department to readmission and death within 90 days: a prospective observational study. Ups. J. Med. Sci. (IF 3.4) Pub Date : 2023-05-03 Lee Ti Davidson,Ulf Martin Schilling,Hans J Arnqvist,Fredrik H Nystrom,Simona I Chisalita
Background Predicting the risk of readmission or death in patients at the emergency department (ED) is essential in identifying patients who would benefit the most from interventions. We aimed to explore the prognostic value of mid-regional proadrenomedullin (MR-proADM), mid-regional pro-atrial natriuretic peptide (MR-proANP), copeptin, and high-sensitivity troponin T (hs-TnT) to identify patients
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Ventilation with the esophageal-tracheal Combitube during general anaesthesia: assessing complications in 540 patients. Ups. J. Med. Sci. (IF 3.4) Pub Date : 2023-04-21 Nicole Harrison,Sahra Pajenda,Lukasz Szarpak,Anna-Maria Buschsieweke,Mostafa Somri,Michael Frass,Bernhard Panning,Oliver Robak
Background The esophageal-tracheal Combitube (ETC) was developed for the management of difficult airways but can also be used for general anaesthesia. Methods This clinical study collected data from patients undergoing anaesthesia with the ETC in order to assess the rate of complications. Results Five hundred forty patients were ventilated with the ETC. In 94.8% (512/540), insertion was performed for
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No effects on heart rate variability in depression after treatment with dorsomedial prefrontal intermittent theta burst stimulation. Ups. J. Med. Sci. (IF 3.4) Pub Date : 2023-03-27 Johan Bengtsson,Erik Olsson,Jonas Persson,Robert Bodén
Background The purpose of this study was to investigate whether treatment of a depressive episode with intermittent theta burst stimulation (iTBS) over the dorsomedial prefrontal cortex (DMPFC) had any effects on heart rate variability (HRV). We also investigated if changes in HRV covaried with symptom change after iTBS and if HRV could predict symptom change. Methods We included 49 patients with a
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Increased levels of a subset of angiogenesis-related plasma proteins in essential thrombocythemia. Ups. J. Med. Sci. (IF 3.4) Pub Date : 2023-03-27 Sofia Vikman,Anders Larsson,Måns Thulin,Torbjörn Karlsson
Background Increased local angiogenesis is important for the growth and dissemination of cancer. The myeloproliferative neoplasm essential thrombocythemia (ET) is known to involve increased bone marrow angiogenesis. Blood levels of several angiogenesis-related proteins are increased in different types of cancer. The aim of this study was to investigate whether a subset of such proteins was elevated
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The Aura-Gain laryngeal mask for airway management in neonatal inguinal hernia surgery. A feasibility study. Ups. J. Med. Sci. (IF 3.4) Pub Date : 2023-02-27 Ali-Reza Modiri,Robert Frithiof,Tomas Luther,Peter Frykholm
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Study protocol: The cross-sectional Uppsala weight gain in pregnancy study (VIGA study). Ups. J. Med. Sci. (IF 3.4) Pub Date : 2023-02-10 Theodora Kunovac Kallak,Alice Zancanaro,Katja Junus,Anna-Karin Wikström,Inger Sundström Poromaa,Susanne Lager
Background More than two in five Swedish women are overweight or obese when becoming pregnant. Maternal overweight or obesity and excessive pregnancy weight gain are associated with several adverse pregnancy outcomes. The underlying mechanisms that link maternal adiposity, diet, exercise, pregnancy weight gain with pregnancy outcome are incompletely understood. Methods We describe the design for a
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Admission of patients with chest pain and/or breathlessness from the emergency department in relation to risk assessment and copeptin levels - an observational study. Ups. J. Med. Sci. (IF 3.4) Pub Date : 2022-12-26 Lee Ti Davidson,Emilia Gauffin,Preben Henanger,Maciej Wajda,Daniel Wilhelms,Bertil Ekman,Hans J Arnqvist,Martin Schilling,Simona I Chisalita
Background One of the most critical decisions that emergency department (ED) physicians make is the discharge versus admission of patients. We aimed to study the association of the decision in the ED to admit patients with chest pain and/or breathlessness to a ward with risk assessment using the Rapid Emergency Triage and Treatment System (RETTS), the National Early Warning Score (NEWS), and plasma
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Increased accuracy in diagnosing diverticulitis using predictive clinical factors. Ups. J. Med. Sci. (IF 3.4) Pub Date : 2022-12-15 Johanna Sigurdardottir,Abbas Chabok,Philippe Wagner,Maziar Nikberg
Background The aim of this study was to identify clinical factors leading to increased diagnostic accuracy for acute colonic diverticulitis. Methods Patients with clinical suspicion of acute colonic diverticulitis verified with computed tomography (CT) from two hospitals in Sweden between 9 January 2017 and 31 October 2017 were prospectively included. Symptoms, comorbidities, and laboratory results
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Health-related quality of life as associated with asthma control, psychological status and insomnia. Ups. J. Med. Sci. (IF 3.4) Pub Date : 2022-11-29 Anna Rask-Andersen,Mai Leander,Fredrik Sundbom,Erik Lampa,Anna Oudin,Bénédicte Leynaert,Cecilie Svanes,Thorarinn Gislason,Kjell Torén,Christer Janson
Background Asthma is associated not only with lower health-related quality of life (HRQL) but also with psychological health and insomnia. The aim of this study was to investigate associations between HRQL, asthma symptoms, psychological status and insomnia in adults from three Nordic countries. Methods This study comprised 2,270 subjects aged 29-55 from Sweden, Iceland and Norway. HRQL was measured
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Toward a granular molecular-anatomic map of the blood vasculature - single-cell RNA sequencing makes the leap. Ups. J. Med. Sci. (IF 3.4) Pub Date : 2022-10-21 Christer Betsholtz
Single-cell RNA sequencing (scRNAseq) marks the birth of a new era in physiology and medicine. Within foreseeable future, we will know exactly what genes are expressed - and at what levels - in all the different cell types and subtypes that make up our bodies. We will also learn how a particular cell state, whether it occurs during development, tissue repair, or disease, reflects precise changes in
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Ulcerative colitis progression: a retrospective analysis of disease burden using electronic medical records. Ups. J. Med. Sci. (IF 3.4) Pub Date : 2022-10-18 David Dahlgren,Lars Agréus,Jan Stålhammar,Per M Hellström
Background Ulcerative colitis (UC) is a debilitating inflammatory bowel disease. Present knowledge regarding UC disease progression over time is limited. Objective To assess UC progression to severe disease along with disease burden and associated factors. Methods Electronic medical records linked with Swedish national health registries (2005-2015) were used to identify disease progression of UC. Odds
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A third dose SARS‑CoV‑2 BNT162b2 mRNA vaccine results in improved immune response in hemodialysis patients. Ups. J. Med. Sci. (IF 3.4) Pub Date : 2022-10-13 Jan Melin,Maria K Svensson,Bo Albinsson,Ola Winqvist,Karlis Pauksens
Background The hemodialysis (HD) population has been a vulnerable group during the coronavirus disease 2019 (COVID-19) pandemic. Advanced chronic kidney disease with uremia is associated with weaker immune response to infections and an attenuated response to vaccines. The aim of this study was to study the humoral and cellular response to the second and third doses of Severe Acute Respiratory Syndrome
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Molecular tools to monitor health and disease - and lucky coincidences. Ups. J. Med. Sci. (IF 3.4) Pub Date : 2022-10-10 Ulf Landegren
Improved methods for molecular analyses are obviously central for medical research. I will describe herein our work developing tools to reveal molecular states in health and disease. I will recount how I got started in this endeavor, and how our early work characterizing genetic variation led onto high-throughput protein measurements and to techniques for imaging the distribution of proteins and their
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Distribution of intraocular pressure in a Swedish population. Ups. J. Med. Sci. (IF 3.4) Pub Date : 2022-10-03 Maria Häkkinen,Curt Ekström
Background Increased intraocular pressure (IOP) and pseudoexfoliation (PEX) are major risk factors for open-angle glaucoma (OAG), an age-related neurodegenerative disease of significant importance for public health. There are few studies on the distribution of IOP in populations where PEX is a common finding. Methods The distribution of IOP was studied in 733 subjects 65-74 years of age, examined in
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Learning from the past to plan for the future: A scoping review of musculoskeletal clinical research in Sweden 2010-2020. Ups. J. Med. Sci. (IF 3.4) Pub Date : 2022-09-30 Elias Diarbakerli,Olof Thoreson,Martin Björklund,Leif E Dahlberg,Martin Englund,Paul Gerdhem,Joanna Kvist,Maziar Mohaddes,Anneli Peolsson,Ola Rolfson,Birgitta Öberg,Allan Abbott
Background The aims of this study are to 1) determine the scope of musculoskeletal (MSK)-related clinical research in Sweden; 2) collate the amount of first-tier funding received; 3) discuss strategies and infrastructure supporting future MSK clinical trials in Sweden. Methods A systematic scoping review protocol was applied in PubMed, Scopus, and SweCRIS databases. The articles were examined, and
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Tissue-based diagnosis of systemic amyloidosis: Experience of the informal diagnostic center at Uppsala University Hospital. Ups. J. Med. Sci. (IF 3.4) Pub Date : 2022-09-27 Justina Damjanovic Vesterlund,Elisabet Ihse,Ulrika Thelander,Alice Zancanaro,Gunilla T Westermark,Per Westermark
Diagnosis of systemic amyloidosis is a clinical challenge and usually relies on a tissue biopsy. We have developed diagnostic methods based on the presence of amyloid deposits in abdominal subcutaneous fat tissue. This tissue is also used to determine the biochemical type of amyloidosis, performed by western blot and immunohistochemical analyses with the aid of in-house developed rabbit antisera and
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Are off-target effects of imatinib the key to improving beta-cell function in diabetes? Ups. J. Med. Sci. (IF 3.4) Pub Date : 2022-09-14 Nils Welsh
The small tyrosine kinase (TK) inhibitor imatinib mesylate (Gleevec, STI571) protects against both type 1 and type 2 diabetes, but as it inhibits many TKs and other proteins, it is not clear by which mechanisms it acts. This present review will focus on the possibility that imatinib acts, at least in part, by improving beta-cell function and survival via off-target effects on beta-cell signaling/metabolic
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Impact of COVID-19 on patients treated with autologous hematopoietic stem cell transplantation: A retrospective cohort study. Ups. J. Med. Sci. (IF 3.4) Pub Date : 2022-08-25 Thomas Silfverberg,Björn Wahlin,Kristina Carlson,Honar Cherif
Objective To describe how coronavirus disease 2019 (COVID-19) affects patients with hematological malignancies treated with autologous hematopoietic stem cell transplantation (ASCT). Methods This retrospective observational cohort study includes all patients with hematological malignancies treated with ASCT in Sweden from 1 January 2020 to 31 December 2020. Patients who subsequently tested positive
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Predictors of post-COVID-19 and the impact of persistent symptoms in non-hospitalized patients 12 months after COVID-19, with a focus on work ability. Ups. J. Med. Sci. (IF 3.4) Pub Date : 2022-08-09 Marta A Kisiel,Helena Janols,Tobias Nordqvist,Jonas Bergquist,Simone Hagfeldt,Andrei Malinovschi,Magnus Svartengren
Background Better knowledge of long-term symptoms following coronavirus disease 2019 (COVID-19), the so-called post-COVID-19, in non-hospitalized patients is needed. The aim of this study was to study persisent symptoms up to 12 months after COVID-19 in non-hospitalized patients and their impact on work ability. We also investigated predictors of persistent symptoms. Methods This study encompassed
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Cognitive behavioral treatment for disordered gaming and problem gambling in adolescents: a pilot feasibility study. Ups. J. Med. Sci. (IF 3.4) Pub Date : 2022-08-08 Frida André,Isak Einarsson,Elisabeth Dahlström,Katalin Niklasson,Anders Håkansson,Emma Claesdotter-Knutsson
Background Disordered gaming and problem gambling (DG/PG) are associated with a range of functional impairments as well as psychiatric comorbidity. With the proliferation of digital gaming apps aimed at children and adolescents, which involve in-game purchases, there is increasing evidence that DG/PG are on the rise in this age range. The behavior can be detected in youth presenting at school-based
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Misinterpretations of P-values and statistical tests persists among researchers and professionals working with statistics and epidemiology. Ups. J. Med. Sci. (IF 3.4) Pub Date : 2022-08-04 Per Lytsy,Mikael Hartman,Ronnie Pingel
Background The aim was to investigate inferences of statistically significant test results among persons with more or less statistical education and research experience. Methods A total of 75 doctoral students and 64 statisticians/epidemiologist responded to a web questionnaire about inferences of statistically significant findings. Participants were asked about their education and research experience
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Management of musculoskeletal pain in patients with idiopathic pulmonary fibrosis: a review. Ups. J. Med. Sci. (IF 3.4) Pub Date : 2022-07-11 Svetlana Kašiković Lečić,Jovan Javorac,Dejan Živanović,Aleksandra Lovrenski,Dragana Tegeltija,Jelena Zvekić Svorcan,Jadranka Maksimović
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, fibrotic, and fatal interstitial lung disease (ILD) of unknown etiology that primarily affects the elderly. Patients with IPF suffer from a heavy symptom burden and usually have a poor quality of life. Dyspnea and dry cough are predominant symptoms of IPF. Although pain is not considered one of the main symptoms of IPF, it can occur for
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Associations between dietary advice on modified fibre and lactose intakes and nutrient intakes in men with prostate cancer undergoing radiotherapy. Ups. J. Med. Sci. (IF 3.4) Pub Date : 2022-06-10 Lisa Söderström,Marina Forslund,Birgitta Johansson,Anna Ottenblad,Andreas Rosenblad
Objectives A variety of non-evidence-based dietary advice on modified fibre and lactose intakes are provided to patients undergoing pelvic radiotherapy to counteract treatment-related bowel symptoms. More knowledge on the nutritional consequences of such advice is needed. This study aimed to explore how advice on modified fibre and lactose intakes during pelvic radiotherapy was associated with nutrient
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The impact of splenectomy on human lipid metabolism. Ups. J. Med. Sci. (IF 3.4) Pub Date : 2022-06-07 Orgun Gunes,Emre Turgut,Yusuf Murat Bag,Ersin Gundoğan,Ajda Gunes,Fatih Sumer
Background Splenectomy impacts hematological, immunological, and metabolic functions of the patient. Since our understanding of its metabolic effects, in particular effects on lipid metabolism, is limited, this study aims to investigate the effects of splenectomy on lipid metabolism. Methods The data from 316 patients undergoing splenectomy between 2009 and 2019 were retrospectively analyzed. Thirty-eight
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Obesity in adolescents associated with vascular aging - a study using ultra-high-resolution ultrasound. Ups. J. Med. Sci. (IF 3.4) Pub Date : 2022-06-03 Tord Naessen,Peter Bergsten,Tobias Lundmark,Anders Forslund
Background Obesity in adolescents is increasing worldwide and associated with an elevated cardiovascular risk later in life. In a group-comparative study, we investigated the association between adiposity in adolescents and signs of vascular aging and inflammation. Methods Thirty-nine adolescents (10-18 years old), 19 with obesity and 20 with normal weight, were enrolled. The intima thickness and intima/media
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Levels of bioactive endogenous lipids and health-related quality of life in Chronic Idiopathic Axonal Polyneuropathy. Ups. J. Med. Sci. (IF 3.4) Pub Date : 2022-05-30 Jonas Lind,Niclas Stensson,Björn Gerdle,Nazdar Ghafouri
Background Although neuropathic pain is a significant problem in polyneuropathy, the underlying molecular mechanisms are poorly understood. The endogenous bioactive lipids 2-arachidonoyl-glycerol (2-AG), oleoylethanolamide (OEA), palmitoylethanolamide (PEA), and stearoylethanolamide (SEA) are known to influence pain and inflammation in the peripheral nervous system. The aim of this study was to explore
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Effect of spironolactone on vascular stiffness in hemodialysis patients: a randomized crossover trial. Ups. J. Med. Sci. (IF 3.4) Pub Date : 2022-05-23 Michael Eklund,Olof Hellberg,Hans Furuland,Yang Cao,Kent Wall,Erik Nilsson
Background The role of spironolactone treatment in hemodialysis patients is debated, but a survival benefit is suggested. Mineralocorticoids and chronic kidney disease have been linked to cardiovascular fibrosis. Therefore, we hypothesized that spironolactone would affect vascular stiffness, cardiac systolic, and diastolic function in hemodialysis patients. Methods This was a randomized crossover study
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Comparison of years of life lost to 1,565 suicides versus 10,650 COVID-19 deaths in 2020 in Sweden: four times more years of life lost per suicide than per COVID-19 death. Ups. J. Med. Sci. (IF 3.4) Pub Date : 2022-05-11 Rickard Ljung,Maria Grünewald,Anders Sundström,Lena Thunander Sundbom,Björn Zethelius
Background The burden of disease from the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic is large; however, suicide affects the population year after year. From a public health perspective, it is important to not neglect contributors to the total burden of disease. The aim of this paper is to compare years of life lost (YLL) to suicide with those lost to coronavirus disease 2019
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Can diffusion tensor imaging (DTI) outperform standard magnetic resonance imaging (MRI) investigations in post-COVID-19 autoimmune encephalitis? Ups. J. Med. Sci. (IF 3.4) Pub Date : 2022-05-10 Francesco Latini,Markus Fahlström,David Fällmar,Niklas Marklund,Janet L Cunningham,Amalia Feresiadou
Background Neurological and psychiatric manifestations related to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection are widely recognised. Standard magnetic resonance imaging (MRI) investigations are normal in 40-80% of symptomatic patients, eventually delaying appropriate treatment when MRI is unrevealing any structural changes. The aim of this study is to investigate white matter
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Detection of paroxysmal atrial fibrillation in 994 patients with a cerebrovascular event by intermittent 21-day ECG-monitoring and 7-day continuous Holter-recording. Ups. J. Med. Sci. (IF 3.4) Pub Date : 2022-05-05 Johanna Pennlert,Mårten Rosenqvist,Milos Kesek
Background The detection of paroxysmal atrial fibrillation (AF) is of importance in stroke care. The method used is continuous electrocardiogram (ECG)-monitoring or multiple short ECG-recordings during an extended period. Their relative efficiency is a matter of discussion. In a retrospective cohort study on 994 patients with an ischemic stroke or transient ischemic attack (TIA), we have compared continuous
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Effects of lipid-lowering treatment intensity and adherence on cardiovascular outcomes in patients with a recent myocardial infarction: a Swedish register-based study. Ups. J. Med. Sci. (IF 3.4) Pub Date : 2022-05-04 Maria K Svensson,Francesc Sorio Vilela,Margrét Leósdóttir,Jonas Banefelt,Maria Lindh,Alexander Rieem Dun,Anna Norhammar,Guillermo Villa
Background Oral lipid-lowering treatment (LLT) is the standard of care for patients with cardiovascular disease (CVD). However, insufficient treatment intensity and poor adherence can lead to suboptimal treatment benefit, rendering patients at increased risk of CVD. Aims The objective of this study was to evaluate trends in LLT intensity and adherence in Sweden over time, and their association with
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Prognostic value of exercise echocardiography in patients with wild-type transthyretin amyloidosis. Ups. J. Med. Sci. (IF 3.4) Pub Date : 2022-03-28 Cristina Aguilera Agudo,Vanessa Moñivas Palomero,Esther González López,Susana Mingo Santos
Background Wild-type transthyretin amyloidosis is a systemic disease with predominantly cardiac symptoms. The aim of this study was to assess the short-term prognosis of these patients through contractile reserve measured by stress echocardiography, given the usefulness that this parameter has demonstrated in other populations. We considered major events as death from any cause and hospitalization
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The retirement of Editor-in-Chief Arne Andersson, Upsala Journal of Medical Sciences 2006-2022: an amazing journey under Arne's stewardship. Ups. J. Med. Sci. (IF 3.4) Pub Date : 2022-03-14 Gerhard Wikström,Michael Welsh
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Development of rapid antigen test prototype for detection of SARS-CoV-2 in saliva samples. Ups. J. Med. Sci. (IF 3.4) Pub Date : 2022-02-25 Agnija Kivrane,Viktorija Igumnova,Elza Elizabete Liepina,Dace Skrastina,Ainars Leonciks,Zanna Rudevica,Svjatoslavs Kistkins,Aigars Reinis,Anna Zilde,Andris Kazaks,Renate Ranka
Background The development of easy-to-perform diagnostic methods is highly important for detecting current coronavirus disease (COVID-19). This pilot study aimed at developing a lateral flow assay (LFA)-based test prototype to detect severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus in saliva samples. Methods Mice were immunized using the recombinant receptor-binding domain (rRBD)
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Desmosomes in squamous cell carcinomas Ups. J. Med. Sci. (IF 3.4) Pub Date : 2022-01-27 Vitorino Modesto dos Santos,Lister Arruda Modesto dos Santos,Taciana Arruda Modesto Sugai
Dear Editor The differential diagnosis of adenocarcinomas and squamous cell cancer may present a challenging task in diagnostic pathology. We appreciated the informative study by Galindo et al. recently published in the Upsala Journal of Medical Science evaluating the expression of three desmosomal proteins in nonsmall cell lung cancer (1). Desmosomes are structures of the plasma membrane participating
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Automated data extraction of electronic medical records: Validity of data mining to construct research databases for eligibility in gastroenterological clinical trials. Ups. J. Med. Sci. (IF 3.4) Pub Date : 2022-01-27 Nora Joseph,Ida Lindblad,Sara Zaker,Sharareh Elfversson,Maria Albinzon,Øyvind Ødegård,Li Hantler,Per M Hellström
BACKGROUND Electronic medical records (EMRs) are adopted for storing patient-related healthcare information. Using data mining techniques, it is possible to make use of and derive benefit from this massive amount of data effectively. We aimed to evaluate validity of data extracted by the Customized eXtraction Program (CXP). METHODS The CXP extracts and structures data in rapid standardised processes
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Endocan as a potential marker in diagnosis and predicting disease severity in COVID-19 patients: a promising biomarker for patients with false-negative RT-PCR. Ups. J. Med. Sci. (IF 3.4) Pub Date : 2022-01-24 Esra Laloglu,Handan Alay
BACKGROUND Endothelial-specific molecule 1 (endocan) has emerged as an inflammatory biomarker in recent years. The purpose of this study was to investigate the diagnostic value of serum endocan levels in the prediction of COVID-19 disease among patients with a false-negative reverse transcription polymerase change reaction (RT-PCR) test, and also to determine its correlation with the clinical severity
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Violence and sexual risk taking reported by young people at Swedish youth clinics. Ups. J. Med. Sci. (IF 3.4) Pub Date : 2022-01-21 Sofia Hammarström,Siw Alehagen,Helena Kilander
BACKGROUND Early identification of sexual risk taking and exposure to violence is fundamental when seeking to strengthen young people's health. The purpose of this study was to study factors associated with sexual risk taking and ill health, as well as to study gender differences, and the associations amongst exposure to multiple forms of violence, sexual risk taking and ill health. METHODS This was
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Impact of treatment with immunomodulators and tumour necrosis factor antagonists on the incidence of infectious events in patients with inflammatory bowel disease. Ups. J. Med. Sci. (IF 3.4) Pub Date : 2022-01-10 Per Andersson,Pontus Karling
BACKGROUND Corticosteroids, immunomodulators (IM) and tumour necrosis factor antagonists (anti-TNF) are commonly used in the treatment of inflammatory bowel disease (IBD) but they also supress the defence against infectious disease. The aim of this study was to analyse the incidence of infectious events in patients with IBD and the association to concomitant medical therapy. METHODS We performed a
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Blood pressure screening in midlife aids in prediction of dementia later in life. Ups. J. Med. Sci. (IF 3.4) Pub Date : 2022-01-03 Linn Moberg,Jerzy Leppert,Simon Liljeström,Mattias Rehn,Lena Kilander,Abbas Chabok
BACKGROUND There is substantial evidence that midlife hypertension is a risk factor for late life dementia. Our aim was to investigate if even high blood pressure at a single timepoint in midlife can predict an increased risk for all-cause dementia, Alzheimer's disease (AD), or vascular dementia (VaD) later in life. METHODS The community-based study population comprised 30,102 dementia-free individuals
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Prevalence and risk factors for age-related cataract in Sweden Ups. J. Med. Sci. (IF 3.4) Pub Date : 2021-12-31 Amee Patel,Krish Patel
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Fertility awareness and intentions among young adults in Greece. Ups. J. Med. Sci. (IF 3.4) Pub Date : 2021-12-31 Ioanna Lardou,Ioannis Chatzipapas,Michail Chouzouris,Panos Xenos,Nikolaos Petrogiannis,Dimitrios Tryfos,Stephanos Chandakas,Themos Grigoriadis,Lina Michala
BACKGROUND Greece has a mean age of first motherhood at 31.5 years, higher than the European average age of 29.4. Delaying conception, however, may be an important non-reversible cause of infertility. The aim of this study was to identify possible knowledge deficits regarding fertility in young adults. METHODS This was an online survey of young adults, regarding information on intention to parenthood
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Response to the Letter to the Editor by Amee Patel. Ups. J. Med. Sci. (IF 3.4) Pub Date : 2021-12-31 Curt Ekström
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The profile of the COvid-19 VACcination register SAFEty study in Sweden (CoVacSafe-SE). Ups. J. Med. Sci. (IF 3.4) Pub Date : 2021-12-10 Rickard Ljung,Anders Sundström,Maria Grünewald,Charlotte Backman,Nils Feltelius,Rolf Gedeborg,Björn Zethelius
BACKGROUND The coronavirus disease 2019 (COVID-19) vaccines have been rapidly implemented in national vaccination programs world-wide after accelerated approval processes. The large population exposure achieved in very short time requires systematic monitoring of safety. The Swedish Medical Products Agency has launched a project platform for epidemiological surveillance to detect and characterise suspected
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Assessing the relationship between systemic immune-inflammation index and mortality in patients with hypertrophic cardiomyopathy. Ups. J. Med. Sci. (IF 3.4) Pub Date : 2021-12-03 Ziqiong Wang,Haiyan Ruan,Liying Li,Xin Wei,Ye Zhu,Jiafu Wei,Xiaoping Chen,Sen He
BACKGROUND This study investigates the predictive value of the systemic immune-inflammation index (SII), which was calculated as platelet × neutrophil/lymphocyte ratio, for all-cause mortality in patients with hypertrophic cardiomyopathy (HCM). METHODS A total of 360 HCM patients were enrolled. They were divided into three groups based on the tertiles of baseline SII. The association between SII and
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Accuracy in detecting major depressive episodes in older adults using the Swedish versions of the GDS-15 and PHQ-9. Ups. J. Med. Sci. (IF 3.4) Pub Date : 2021-10-20 Johnny Pellas,Mattias Damberg
OBJECTIVES The purpose of this study was to evaluate the diagnostic accuracy at different cut-off values for the Swedish versions of the 15-item Geriatric Depression Scale (GDS-15) and Patient Health Questionnaire (PHQ-9) compared with a structured clinical psychiatric interview in older adults. METHODS Community-dwelling participants (N = 113) aged 65 years or older completed the Swedish versions
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Elevated gaseous luminal nitric oxide and circulating IL-8 as features of Helicobacter pylori-induced gastric inflammation. Ups. J. Med. Sci. (IF 3.4) Pub Date : 2021-10-15 Hiwa K Saaed,Lisa Chiggiato,Dominic-Luc Webb,Ann-Sofie Rehnberg,Carlos A Rubio,Ragnar Befrits,Per M Hellström
BACKGROUND Gastric nitric oxide (NO) production in response to Helicobacter pylori via inducible nitric oxide synthase (iNOS) is suggested as a biomarker of inflammation and cytotoxicity. The aim of this study was to investigate relationships between gastric [NO], immunological biomarkers and histopathology. MATERIALS AND METHODS Esophagogastroduodenoscopy was done in 96 dyspepsia patients. Luminal
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The association between BMI and 90-day mortality in patients with and without diabetes seeking care at the emergency department. Ups. J. Med. Sci. (IF 3.4) Pub Date : 2021-09-16 Per Wändell,Axel C Carlsson,Anders Larsson,Olle Melander,Torgny Wessman,Johan Ärnlöv,Toralph Ruge
BACKGROUND The impact of body mass index (BMI) on mortality varies with age and disease states. The aim of this research study was to analyse the associations between BMI categories and short- and long-term mortality in patients with or without diabetes seeking care at the emergency department (ED) with acute dyspnoea. POPULATION AND METHODS Patients aged ≥18 years at ED during daytime on weekdays
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Assembly of tetraspanins, galectin-3, and distinct N-glycans defines the solubilization signature of seminal prostasomes from normozoospermic and oligozoospermic men. Ups. J. Med. Sci. (IF 3.4) Pub Date : 2021-09-03 Tamara Janković,Jelena Danilović Luković,Irena Miler,Ninoslav Mitić,Ljiljana Hajduković,Miroslava Janković
BACKGROUND Prostasomes, extracellular vesicles (EVs) abundantly present in seminal plasma, express distinct tetraspanins (TS) and galectin-3 (gal-3), which are supposed to shape their surface by an assembly of different molecular complexes. In this study, detergent-sensitivity patterns of membrane-associated prostasomal proteins were determined aiming at the solubilization signature as an intrinsic
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Mortality in Eosinophilic Esophagitis - a nationwide, population-based matched cohort study from 2005 to 2017. Ups. J. Med. Sci. (IF 3.4) Pub Date : 2021-08-31 Lovisa Röjler,John J Garber,Bjorn Roelstraete,Marjorie M Walker,Jonas F Ludvigsson
BACKGROUND There is a lack of knowledge about mortality in eosinophilic esophagitis (EoE). Therefore, this study aimed to examine the mortality in EoE. METHODS A nationwide, population-based matched cohort study was conducted of all EoE patients in Sweden diagnosed between July 2005 and December 2017. Individuals with EoE (n = 1,625) were identified through prospectively recorded histopathology codes