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Correction Andrologia (IF 2.4) Pub Date : 2023-01-23
In an article (Ali Abd El-Rahman & Omar, 2022) titled “Ameliorative effect of avocado oil against lufenuron induced testicular damage and infertility in male rats” by Heba Ali Abd El-Rahman, Amel Ramadan Omar, there were errors in Tables 2-5. The revised Tables 2-5 are shown below: TABLE 2. Displaying the sperm counting, motility, and viability (%) Groups Control Oil Lf Lf + oil F-value p-value Measurement
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Testosterone and lifespan in males: At the right time and the right level. Andrologia (IF 2.4) Pub Date : 2022-11-24 Lishi Wang,Heliang Yin,Weikuan Gu
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CORRIGENDUM Andrologia (IF 2.4) Pub Date : 2022-11-24
In the article (Zhu et al., 2020), was published with incorrect Figures 2, 4 and 5 which should have been corrected. The correct figures can be found below: FIGURE 2 Open in figure viewerPowerPoint FIGURE 4 Open in figure viewerPowerPoint FIGURE 5 Open in figure viewerPowerPoint
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CORRIGENDUM Andrologia (IF 2.4) Pub Date : 2022-11-23
In the article (Qu et al., 1), it has come to our attention that the published version of Wound healing assays (Figure 2D&5D) and Transwell assays (Figure 2F&5E) are incorrect. The correct figures can be found below: Figure 2: Figure 5: We apologize for this error.
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Jujing Zhuyu decoction inhibits apoptosis in rats with asthenozoospermia by regulating the mitochondrial apoptosis pathway Andrologia (IF 2.4) Pub Date : 2022-11-15 Xuyao Lin, Qingrui Li, Hongying Li, Chenxi Li, Pule Ye, Shuhui Chen, Yu Lu, Zhuojun Yuan, Guozheng Qin
Jujing Zhuyu decoction (JZD) is a traditional Chinese medicine that effectively improves sperm motility. However, the molecular mechanism of JZD on asthenozoospermia still remains unknown. In this study, we investigated the effect of JZD on the mitochondrial apoptosis pathway in an asthenozoospermia rat model. Sixty Sprague–Dawley rats were randomly divided into five groups—control, tripterygium glycosides
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Microfluidic devices employing chemo- and thermotaxis for sperm selection can improve sperm parameters and function in patients with high DNA fragmentation Andrologia (IF 2.4) Pub Date : 2022-11-15 Mohammad Reza Doostabadi, Esmat Mangoli, Laleh Dehghan Marvast, Fatemeh Dehghanpour, Behnam Maleki, Hossein Torkashvand, Ali Reza Talebi
Conventional sperm processing uses centrifugation has a negative effect on sperm parameters and DNA integrity. We designed and fabricated a novel microfluid device based on chemotaxis and thermotaxis, and compared it with the swim-up method. Twenty normal samples with high DNA fragmentation were included. Each sample was divided into four groups: Group 1, control, Group 2: sperm selection by thermotaxis
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Identification of some calcium binding proteins and neural cell markers in rat testis and epididymis during postnatal development Andrologia (IF 2.4) Pub Date : 2022-11-14 Mehmet Özbek, Feyzullah Beyaz, Emel Ergün, Levent Ergün, Harun Karaca, Ahmet Cabir, Yahy Abood Kareem Alesawi
Calcium-binding proteins (CaBPs) have an essential role in male reproduction by modulating calcium ion metabolism. Although the brain and testis are structurally and functionally different, they show a high degree of transcriptomic and proteomic similarities. The purpose of the present study was to explore some CaBPs (Iba-1, Calbindin, Calretinin and Parvalbumin) and neural cell markers (CNPase, NG2
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Exploring the mechanisms of Gui Zhi Fu Ling Wan on varicocele via network pharmacology and molecular docking Andrologia (IF 2.4) Pub Date : 2022-11-13 Ruipeng Wang, Xiaoye Qiao, Xiaobin Wang
Varicocele (VC) is a common urogenital disease that leads to a high risk of testicular pain or male infertility. The purpose of this research was to explore the molecular mechanism of the Gui Zhi Fu Ling Wan (GFW) in the treatment of VC. The main active ingredients and targets information of GFW were screened by Traditional Chinese Medicine Systems Pharmacology (TCMSP) database, and the targets related
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Effects of fish oil on methotrexate-induced reproductive damage in rats Andrologia (IF 2.4) Pub Date : 2022-11-11 Volkan Ipek, Kursat Kaya, Cigdem Cebi, Ali Gurel, Leyla Elif Ozgu Ayozger
Methotrexate (MTX) is a folic acid antagonist that is commonly used in paediatric and adult oncology to treat a variety of malignancies. Internal organs, including the testis, are severely cytotoxic and genotoxic to MTX. Omega-3, as an antioxidant, has been shown to protect rat testis tissue from injury. The effect of fish oil (FO) on MTX-induced reproductive damage in rats was investigated in this
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A comparative study of the efficacy of tamoxifen and Chinese patented medicine (Pingxiao capsules) in gynecomastia: A retrospective cohort study Andrologia (IF 2.4) Pub Date : 2022-11-11 Qianli Yao, Hening Zhai, Hailang Huang, Junnan Lin, Weili He
To compare the clinical efficacy of tamoxifen and Chinese patented medicine (Pingxiao capsules) in patients with gynecomastia and discuss the safety of the two treatments. We retrospectively analysed the clinical data of 388 male patients with gynecomastia who were treated in the Outpatient Clinic of our hospital between January 2010 and December 2020. There were 103 patients in the tamoxifen (TAM)
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In memory of Arif Adimoelja- the father of modern andrology in Indonesia. Andrologia (IF 2.4) Pub Date : 2022-11-10 Wolf-Bernhard Schill
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Transverse testicular ectopia with persistent Mullerian duct syndrome: Report and review of two cases Andrologia (IF 2.4) Pub Date : 2022-11-10 Min Yang, Xiaobin Lin, Zhijun Liu, Peijian Zhang, Wang Xiao, Yingchun Chen, Yiyi Chen, Yangmu Zhuang, Lian Zheng, Shouxing Duan
Transverse testicular ectopia is a rare anomaly characterized by both testes descending through a single inguinal canal. The objective of this study was to investigate the pathogenesis, diagnosis, and treatment of transverse testicular ectopia (TTE) with persistent Mullerian duct syndrome (PMDS), and to deepen the understanding of the disease in clinical. A retrospective analysis of the clinical manifestation
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In vivo exposure to a new 2-cyano-2-p-nitrophenyl-N-benzylthioamide decreases doxorubicin-triggered structural damages in the mature testis Andrologia (IF 2.4) Pub Date : 2022-11-10 Marwa Boussada, Imen Hammami, Ridha Ben Ali, Awatef Ben Ammar, Marco Alves, Pedro Fontes Oliveira, Azaiez Ben Akacha, Ines Limam Abdelkarim, Sami Zekri, Michèle Véronique El May
The use of doxorubicin (DOX) in clinical practice continues to be challenged by its severe toxicity. DOX cytotoxic activity is not only directed against malignant tumours, given that the treatment will damage healthy tissues as well leading to irreversible injuries. This study aimed to address the in vivo effects of DOX and its co-administration with a new analog of thioamide; thiocyanoacetamide (TA)
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Aqueous extract of Massularia acuminata exerts erectogenic effect by modulating critical enzymes and hormones in streptozotocin-induced erectile dysfunction in rats Andrologia (IF 2.4) Pub Date : 2022-11-09 Stephen Adeniyi Adefegha, Ganiyu Oboh, Abraham Olanrewaju Adedipe
Massularia acuminata stem is often used in folkloric medicine in the management of erectile dysfunction (ED), without full scientific basis for its action. Thus, the effects of aqueous extract of M. acuminata stem (MAS) on sexual activity, hormonal action, enzymatic activity and levels of molecules associated with erectile function were assessed. ED was induced by single intraperitoneal injection of
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A rare abnormality of ejaculatory duct opening in the bladder trigone in a 33-year-old male associated with primary infertility: Case report and literature review Andrologia (IF 2.4) Pub Date : 2022-11-09 Ahmed Albakr, Mohamed Arafa, Ahmad Majzoub, Walid El Ansari, Mamon Qasem, Sami Al Said, Haitham Elbardisi
Genitourinary anomalies constitute a large proportion of congenital malformations. However seminal tract anomalies, particularly ejaculatory duct (ED) anomalies are very rare and little information exists on the topic. We are reporting a very rare case of bilateral ectopic EDs opening in the bladder trigone in a 33-year-old gentleman presenting for evaluation for primary infertility. The patient's
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Nutraceutical potential of almond fruits in managing diabetes-related erectile dysfunction: Effect on Nrf-2 level and smooth muscle/collagen ratio Andrologia (IF 2.4) Pub Date : 2022-11-08 Adeniyi A. Adebayo, Ganiyu Oboh, Ayokunle O. Ademosun
Oxidative stress is one of the major crosstalk between diabetes and erectile dysfunction. Tropical almond is a natural antioxidant that works in a way to neutralize the effect of reactive oxygen species in disease management. This study therefore aimed to evaluate the effects of tropical almond on the nuclear factor erythroid-2-related factor-2 (nrf-2) level and smooth muscle/collagen ratio, as well
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Recovery of hypothalamic–pituitary–gonadal function with low dose testosterone treatment in a male with congenital hypogonadotropic hypogonadism Andrologia (IF 2.4) Pub Date : 2022-11-08 Fernando Braca, Juan C. Betancort, Nuria Pérez-Martín, Alvaro Cabrera Argany, Mauro Boronat
Congenital hypogonadotropic hypogonadism (CHH) is a rare disease caused by deficiency or action of gonadotropin-releasing hormone. While generally considered a long-life condition, CHH can be reversible in about 5%–20% of cases, but mechanisms of reversibility are unknown. We report the case of a male with CHH who began treatment with low dose (20 mg/day) transdermal testosterone to induce pubertal
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Iron oxide nanoparticles reversibly affect sperm quality in Wistar rats Andrologia (IF 2.4) Pub Date : 2022-11-07 Gajraj Singh Verma, Naresh Kumar Nirmal, Placheril J. John
Iron oxide nanoparticles (IONP) are being utilised for various biomedical applications due to their unique properties like superparamagnetism and greater colloidal stability. Interaction of IONP with male reproductive system is underrepresented in the literature. Current study strives to demonstrate the effects of IONP on sperm quality, reproductive hormones and fertility of adult Wistar rats. Spherical
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N-acetyl-l-cysteine and alpha lipoic acid are protective supplement on human sperm parameters in cryopreservation of asthenoteratozoospermia patients Andrologia (IF 2.4) Pub Date : 2022-11-01 Rahil Jannatifar, Elham Asa, Seyedeh Saeideh Sahraei, Atefeh Verdi, Hamid Piroozmanesh
The aim of this study is to evaluate the beneficial effects of N-acetyl-cysteine (NAC), alpha lipoic acid (ALA) and combination of NAC + ALA supplement in freezing medium on Sperm structural and functional in asthenoteratozoospermia patients. Thirty freshly ejaculated semen samples were cryopreserved with sperm freezing medium (SFM) as control group and three group that SFM supplemented with NAC, ALA
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The most common recurrent reciprocal translocation: T(11; 22)(q23; q11). Andrologia (IF 2.4) Pub Date : 2022-10-28 Xiaochuan Chen,Zhaoliang Yu,Shuqin Chen,Yijia Zhou
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A new diagnostic definition for patients with lower urinary tract symptoms evaluated by corpus cavernosum electromyography: ‘Pelvic autonomic dysfunction’ Andrologia (IF 2.4) Pub Date : 2022-10-26 Önder Kayigil, Yucel Altay, Emrah Okulu
This study investigates the use of corpus cavernosum electromyography (CC-EMG) recording as a diagnostic tool for identifying the presence of pelvic autonomic dysfunction (PAD) in patients with LUTS and concurrent ED. Fifty patients were included in the study, and the electromyographic and urodynamic findings were compared. The 50% relaxation degree was accepted as a threshold value for PAD. According
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A novel solution for freezing individual spermatozoa using a right angular cryopiece embedded in a grooved petri dish Andrologia (IF 2.4) Pub Date : 2022-10-26 Ling-Ying Jiang, Fei-Fei Kong, Lv Yao, Fu-Xing Zhang, Sha-Sha Wang, Xiao-Ying Jin, Xiao-Mei Tong, Song-Ying Zhang
Herein, we introduced a novel individual sperm freezing device named SpermCD, which consists of a right angular cryopiece (RA-Cryopiece, or “C”) and a grooved petri dish (“D”). SpermCD allows embryologists to transfer sperm and perform ICSI on the same focal plane. Thirty-five patients underwent single sperm cryopreservation using SpermCD, including four patients with non-obstructive azoospermia (NOA)
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Targeting soluble guanylate cyclase with Riociguat has potency to alleviate testicular ischaemia reperfusion injury via regulating various cellular pathways Andrologia (IF 2.4) Pub Date : 2022-10-25 Ugur Seker, Deniz Evrim Kavak, Baris Can Guzel, Saime Betul Baygeldi, Meral Yuksel, Ozlem Unay Demirel, Sevgi Irtegun Kandemir, Dila Sener
Testicular ischaemia reperfusion (I/R) injury results with serious dysfunctions in testis. This study aims to explore effects of soluble guanylate cyclase (sGC) stimulator Riociguat on experimental testicular I/R injury in rats. Twenty-one male rats were divided into three groups (Control, IR and IRR). The control group was not exposed to any application. Bilateral testis from IR and IRR animals were
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Relationship between long-term use of Ritalin and semen parameters in patients referred to psychiatric centres Andrologia (IF 2.4) Pub Date : 2022-10-23 Fereshteh Aliakbari, Jalil Hosseini, Reza Hashemi, Soraya Moamer, Zahra Sadeghzade, Fatemeh Rezaei-Tazangi, Keshvar Samadae Gelehkolee, Mostafa Hamdieh
Some studies have shown that Ritalin can interfere with the growth and development of the reproductive system and can also have a serious and harmful effect on sperm parameters, so we decided to conduct studies in this field on the human sample. In a case–control study, 100 adult men aged 21–31 years with hyperactivity were divided into two groups of 50 past users and 50 current users and, 50 patients
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Association between international index of erectile function-5 scores and circadian patterns of newly diagnosed hypertension in erectile dysfunction patients Andrologia (IF 2.4) Pub Date : 2022-10-22 Umit Yildirim, Muammer Karakayali, Mehmet Uslu, Mehmet Ezer, Ismet Bilger Erihan, Inanc Artac, Timor Omar, Yavuz Karabag, Ibrahim Rencuzogullari
By the beginning of this study in 2019, it was known that hypertension is a risk factor for erectile dysfunction, and also, there are circadian changes that occur in blood pressure. Further, non-dipping hypertension is known to be linked to poor cardiac outcomes and erectile functions, so the research described in this article was initiated with an aim to explore the potential relationship between
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Chromosome 17 translocation affects sperm morphology: Two case studies and literature review Andrologia (IF 2.4) Pub Date : 2022-10-21 Shan Huang, Yingting Huang, Shan Li, Yu He
We present two cases of infertile males with teratozoospermia stemming from chromosome 17 translocation. The patients present karyotypes that have not been previously reported. Genes located on breakpoints (17p11.2, 9q31, and 11p15) were analysed to find the probable mechanism affecting sperm morphology. Our results suggest that ALKBH5, TOP3A, and LLGL1 interactions may be an underlying cause of abnormal
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Conditioned medium of bone marrow mesenchymal stem cells improves sperm parameters and reduces histological alteration in rat testicular ischaemia/reperfusion model Andrologia (IF 2.4) Pub Date : 2022-10-21 Parya Sharifian, Siamak Yari, Parisa Hasanein, Yalda Manteghi Nezhad
Testis ischaemia–reperfusion (I/R) plays a vital role in male infertility. Recent studies have demonstrated that paracrine factors of mesenchymal stem cells exert the transplanted cells' reparative effects. The present experimental study aimed to investigate the effects of conditioned medium (CM) of bone marrow-derived mesenchymal stem cells (BMMSCs). In this study, 21 rats were separated into three
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Antioxidant and anti-apoptotic effects of selenium nanoparticles and Lactobacillus casei on mice testis after X-ray Andrologia (IF 2.4) Pub Date : 2022-10-20 Alireza Ehghaghi, Elham Zokaei, Mohammad Hossein Modarressi, Gholamreza Tavoosidana, Soudeh Ghafouri-Fard, Faeze Khanali, Elahe Motevaseli, Zahra Noroozi
Radiation can lead to various damages in the process of spermatogenesis that lead to a decrease in the number of sperm, an increase in spermatogenesis disorders, and defective sperm function. Radioprotectors are considered a good approach to reducing the damage caused by radiation. The goal of this work was to study how X-ray radiation affects testicular tissue and the process of spermatogenesis, as
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Contributions of seminal plasma proteins to fertilizing ability of bull sperm: A meta-analytical review Andrologia (IF 2.4) Pub Date : 2022-10-19 Arabela Guedes de Azevedo Viana, Iara Magalhães Ribeiro, Renner Philipe Rodrigues Carvalho, Erdogan Memili, Arlindo de Alencar Moura, Mariana Machado-Neves
Seminal plasma is a dynamic, intricate combination of fluids from the testicles, epididymides, seminal vesicles, bulbourethral glands, and prostate, containing molecules that modulate sperm functions, post-fertilization events, and the female reproductive tract physiology. Significant variations in sperm parameters and fertility status of bulls relate to differences in the seminal plasma proteome.
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The impact of dolutegravir-based combination antiretroviral therapy on the spermatozoa and fertility parameters of men living with human immunodeficiency virus Andrologia (IF 2.4) Pub Date : 2022-10-19 Edidiong N. Akang, Olufunke O. Dosumu, Ann A. Ogbenna, Utom-obong U. Akpan, Jane C. Ezeukwu, Mayowa O. Odofin, Ademola A. Oremosu, Alani S. Akanmu
The factors responsible for this reported fertility decline among human immunodeficiency virus (HIV) positive men is yet to be determined. This study is aimed at investigating the impact of HIV or combination antiretroviral therapy (cART) on sperm cells, reproductive hormones, oxidative stress markers, apoptosis, and sperm DNA fragmentation of men living with HIV. Twenty-one men living with HIV gave
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Are androstenedione, dihydrotestosterone, thyroid-stimulating hormone, insulin-like growth factor I, and insulin-like growth factor binding protein 3 necessary for isolated micropenis healthy boys' evaluation without any phenotypic abnormalities? A cross-sectional study Andrologia (IF 2.4) Pub Date : 2022-10-18 Soheila Siroosbakht, Sadra Rezakhaniha, Bijan Rezakhaniha
The study aimed to familiarise primary care physicians and specialists with the minimum hormonal diagnostic tests necessary to assay isolated micropenis in healthy children without any phenotypic abnormality. Children aged 6–15 years (mean 11.6 ± 1.68) were assessed from May 2010 to September 2021 (N = 247). Multiple regression analysis showed correlations between stretched penile length (SPL) and
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Scutellarein stimulates human sperm function by increasing the levels of intracellular calcium and tyrosine phosphorylation Andrologia (IF 2.4) Pub Date : 2022-10-18 Zhihong Sun, Wenqing Xu, Yuan Yuan, Dandan Song, Houyang Chen, Tao Luo, Ying Chen
As a kind of flavonoid, scutellarein is widely used to protect against various human diseases. Although the protective effects of scutellarein have been well studied, its influence on human reproduction remains unknown. In this research, we evaluated the effect of scutellarein on human sperm functions in vitro. Three different concentrations of scutellarein (1, 10, 100 μM) were applied to ejaculated
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Assessing the quality and readability of online content on shock wave therapy for erectile dysfunction Andrologia (IF 2.4) Pub Date : 2022-10-14 Raghuram V. Reddy, Roei Golan, Justin Loloi, Parris Diaz, Russell G. Saltzman, Arjun Watane, Ranjith Ramasamy
Patients are becoming increasingly reliant on online platforms for obtaining health information. Previous research has shown that the quality of information available on the internet regarding novel medical therapies is generally poor and frequently misleading. Shock wave therapy represents a novel restorative therapy for erectile dysfunction (ED) that has recently gained attention. We hypothesised
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Production and characterization of a new specific monoclonal antibody against A-isoform of SALL4: A novel emerging testicular cancer marker Andrologia (IF 2.4) Pub Date : 2022-10-13 Niknam Lakpour, Roya Ghods, Mohammad Reza Sadeghi, Mohammad Mehdi Ranjbar, Maryam Abolhasani, Jafar Kiani, Kioomars Saliminejad, Leila Balay-Goli, Ali Ahmad Bayat, Fahimeh Souri, Zahra Madjd
SALL4 transcription factor plays an important role to maintain the pluripotent and self-renewal of embryonic stem cells. It contributes to the growth of many cancers and embryonic development. With the exception of spermatogonia, SALL4 expression is silenced in most adult tissues after birth; nevertheless, it is re-expressed in a subset of different solid malignancies. SALL4 is a new, precise biomarker
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Impact of tobacco smoking in association with H2BFWT, PRM1 and PRM2 genes variants on male infertility Andrologia (IF 2.4) Pub Date : 2022-10-10 Houda Amor, Peter Michael Jankowski, Fatina W. Dahadhah, Mazhar Salim Al Zoubi, Mohamad Eid Hammadeh
Tobacco's genotoxic components can cause a wide range of gene defects in spermatozoa such as single- or double-strand DNA breaks, cross-links, DNA-adducts, higher frequencies of aneuploidy and chromosomal abnormalities. The aim in this study was to determine the correlation between sperm quality determined by standard parameters, sperm DNA maturity tested by Chromomycin A3 (CMA3) staining, sperm DNA
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Elastography and contrast-enhanced ultrasound to assess the effect of varicocelectomy: A case-controlled study Andrologia (IF 2.4) Pub Date : 2022-10-10 Wen Cao, Hu Han, Xing Guan, Chaoyang Lyu, Qian Zhou, Long Tian, Ruijun Guo
To evaluate the changes in testicular stiffness and microcirculation caused by spermatic vein ligation in patients with varicocele, we conducted a case-controlled study. A total of 27 grade III left varicocele cases were enrolled. Testicular stiffness and perfusion were evaluated by shear wave elastography and contrast-enhanced ultrasound during subinguinal microscopic varicocelectomy. The external
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Beneficial effects of Spirulina platensis on mice testis damaged by silver nanoparticles Andrologia (IF 2.4) Pub Date : 2022-10-10 Hossein Moghanlo, Seyed Mohammad Ali Shariatzadeh
Silver nanoparticles (AgNPs) have been used widely in medical applications and various industries. Humans could be exposed to the risk of AgNPs toxicity through different routes. The current study aimed to investigate the role of Spirulina platensis (SP) against the side effects of AgNPs on mice testis. Adult male NMRI mice were divided into four groups: control group, SP group (300 mg/kg bwt), AgNPs
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Assessment of the potential toxic effect of magnetite nanoparticles on the male reproductive system based on immunological and molecular studies Andrologia (IF 2.4) Pub Date : 2022-10-10 Aya Gamal, Laila E. Kortam, Abd El Wahab El Ghareeb, Heba Ali Abd El Rahman
Magnetite nanoparticles (MNPs) are the most conventional type of iron oxide nanoparticles used in the food industrial processes, removal of heavy metals, and biomedical applications in vivo or in vitro. Until now, there is no sufficient information that can confirm its effect on the body's immune system and reproductive health in males. The purpose of this research is to estimate the immunotoxic and
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Seminal trace elements and their relationship with sperm parameters Andrologia (IF 2.4) Pub Date : 2022-09-29 Seda Karabulut, Serol Korkmaz, Ertuğrul Güneş, Erol Kabil, İlknur Keskin, Melek Usta, Gülden Zehra Omurtag
Male reproductive problems may derive from many reasons including the environmental toxicants which may either intaken by occupational exposure, nutrition or bad air quality. The increased exposure to these substances due to rapid industrial development and technology has raised the questions: Is there a relationship between sperm parameters and these substances, and if so, in what extent? Results
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Overview of biological effects of melatonin on testis: A review Andrologia (IF 2.4) Pub Date : 2022-09-28 Somayeh Heidarizadi, Zahra Rashidi, Cyrus Jalili, Mohammadreza Gholami
Infertility is a major global health issue and male factors account for half of all infertility cases. One of the causes of male infertility is the loss of spermatogonial stem cells, which may occur because of chemotherapy, radiotherapy or genetic defects. In numerous animal species, the evidence suggests the pineal gland and melatonin secretion in their reproductive activities are involved. Recently
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Trabectedin (ET-743) in prostate cancer: Endoplasmic reticulum stress-induced apoptotic effect Andrologia (IF 2.4) Pub Date : 2022-09-27 Harika Atmaca, Ferdi Oğuz, Suleyman Ilhan
Trabectedin is a chemotherapy agent originating from a tunicate, Ecteinascidia turbinata. In this study, DNA-independent action mechanisms of trabectedin are investigated in prostate cancer (PCa) cells. Cell viability was assessed via XTT assay. Apoptosis was evaluated via flow cytometry. Tetramethylrodamine ethyl ester (TMRE) dye was utilized to determine mitochondrial membrane potential (MMP). Cell
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The evaluation of citral effects on experimental unilateral testicular ischemia/reperfusion injury Andrologia (IF 2.4) Pub Date : 2022-09-26 Bijan Rezakhaniha, Vahid Ganjiani, Soheila Siroosbakht, Nasrollah Ahmadi, Abdolhamid Meimandi-Parizi, Mohammad-Reza Divar, Hassan Shrifiyazdi, Seyed-Mehdi Mirghazanfari
This investigation aimed to evaluate the defensive impacts of citral on ischemia/reperfusion (I/R) injury induced by testicular torsion/detorsion (T/D) in rats in an experimental model. The grouping of subjects was as follows: (1) sham, (2) T/D, (3) and (4) T/D plus citral 150 and 300 mg/kg, respectively, and (5) intact (citral 300 mg/kg). T/D was performed by testicular 720° turning for 2 h and then
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Examining changes on testicular structure and sperm analysis of COVID-19 patients Andrologia (IF 2.4) Pub Date : 2022-09-26 Kasım Ertaş, Recep Eryilmaz, Adem Yokuş, Kadir Körpe, Nurullah Gedük, Mazlum Özkan, Rahmi Aslan
This study aimed to examine the testicular functions with sperm analysis of patients with COVID-19. The study was carried out with male patients aged between 18 and 50 years with positive RT-PCR test and SARS-CoV-2 virus between December 2020 and April 2021. A total of 103 participants were included in the study. The mean age was 31.24 ± 5.67 (19–45) years and the mean body mass index of the participants
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Relaxation mechanisms of chloroform root extracts of Prangos heyniae and Prangos uechtritzii on mouse corpus cavernosum Andrologia (IF 2.4) Pub Date : 2022-09-26 Elif Alan, Gokay Albayrak, Gulnur Sevin, Gunay Yetik-Anacak, Sura Baykan
Erectile dysfunction (ED) is the inability to achieve/maintain an erection. Because of the side effects, interactions, or ineffectiveness of currently used drugs, novel drug discovery studies are ongoing. The roots of Turkish endemic plants Prangos uechtritzii and Prangos heyniae are traditionally used as aphrodisiacs in Anatolia and contain coumarin-like relaxant compounds. This study aims to reveal
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Effects of dietary supplementation of different oils and conjugated linoleic acid on the reproductive and metabolic aspects of male mice Andrologia (IF 2.4) Pub Date : 2022-09-25 Mohamad Safari Hasanabad, Mehrdad Ghorbanlou, Reza Masoumi, Saeed Shokri, Behnam Rostami, Hamidreza Mirzaei-Alamouti, Sally Catt, Mark P. Green, Reza Nejatbakhsh
The present study was carried out to examine first, if diets enriched with 320 g of the base diet with common dietary oils including fish oil, olive oil, hydrogenated sunflower seed (H-SFS) oil, flaxseed oil and sunflower seed oil (SFS) could induce weight gain and alter reproductive and metabolic characteristics of male mice. Second, whether the addition of conjugated linoleic acid (CLA, 10% of the
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Evaluation of a single dose of intra-testicular insulin treatment in heat-stressed mice model Andrologia (IF 2.4) Pub Date : 2022-09-25 Malsawmhriatzuala Jeremy, Guruswami Gurusubramanian, Rajesh Kumar Kharwar, Vikas Kumar Roy
Insulin plays important role in testicular functions such as germ cell proliferation and steroidogenesis, despite its conventional role as a hypoglycaemic agent. It is also well known that testicular activity is severely get affected by heat stress and heat stress induces testicular pathogenesis. The effect of insulin on heat-induced testicular impairment has not been investigated. Thus, it is hypothesized
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Interaction between apoptosis and autophagy in testicular function Andrologia (IF 2.4) Pub Date : 2022-09-25 Damilare E. Rotimi, Shio Kumar Singh
Several processes including oxidative stress, apoptosis, inflammation and autophagy are related to testicular function. Recent studies indicate that a crosstalk between apoptosis and autophagy is essential in regulating testicular function. Autophagy and apoptosis communicate with each other in a complex way, allowing them to work for or against each other in testicular cell survival and death. Several
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Is there a relationship between mean platelet volume and response to treatment with daily tadalafil in patients with erectile dysfunction? Andrologia (IF 2.4) Pub Date : 2022-09-22 Caner Baran, Musab Ümeyir Karakanlı, Mehmet Gokhan Culha, Levent Özcan, Alper Ötünçtemur
Mean platelet volume (MPV) has been related to erectile dysfunction (ED). However, its value in predicting therapeutic response to phosphodiesterase-5 inhibitors is not evaluated. This study aimed to investigate the value of MPV as a marker for the prediction of the response of the tadalafil treatment of ED. A retrospective analysis of patients who were admitted to the andrology outpatient clinic between
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Exercise improves testicular morphology and oxidative stress parameters in rats with testicular damage induced by a high-fat diet Andrologia (IF 2.4) Pub Date : 2022-09-22 Merve Acikel Elmas, Ozlem Bingol Ozakpinar, Meltem Kolgazi, Goksel Sener, Serap Arbak, Feriha Ercan
Obesity and male infertility are problems that affect population. Exercise is a nonpharmacological way to reduce the negative health effects of obesity. The purpose of this study was to examine the effects of exercise on hormone levels, blood-testis barrier, and inflammatory and oxidative biomarkers in rats that became obese due to a high-fat diet (HFD). Male rats received a standard diet (STD group)
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Reversal of idiopathic hypogonadotropic hypogonadism in a Chinese male cohort Andrologia (IF 2.4) Pub Date : 2022-09-19 Taotao Sun, Wenchao Xu, Yinwei Chen, Yonghua Niu, Tao Wang, Shaogang Wang, Hao Xu, Jihong Liu
Idiopathic hypogonadotropic hypogonadism (IHH) is a rare genetically heterogeneous disease and characterized by incomplete or absent puberty and infertility. It is worth noting that partial IHH patients could recover reproductive endocrine function following treatment, which is termed reversal. This study aimed to investigate clinical and genetic characteristics of IHH reversal patients. A total of
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Overlapping sperm damages from vitamin B or D deficiency in mice: Insights into the role of clinical supplementations Andrologia (IF 2.4) Pub Date : 2022-09-19 Farnaz Pouriayevali, Marziyeh Tavalaee, Taghi Taktaz-Hafshejani, Maurizio Dattilio, Mohammad H. Nasr-Esfahani
In this study, the effect of 14 weeks of standard diet (controls) or folate and vitamin B12-free diet (VBD group) or vitamin D-free diet (VDD group) were assessed on mice testicular function, and sperm function. Vitamin D deprivation caused increased body weight with no effect from VBD confirming the calcium-independent role of vitamin D on body weight homeostasis. The two deprivations caused convergent
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Improved cell proliferation and testosterone secretion following exposure of TM3 Leydig cells to three-dimensional scaffold and light emitting diode Andrologia (IF 2.4) Pub Date : 2022-09-19 Badrossadat Alavi, Mohammad Shojaei, Tahereh Haghpanah, Vida Mirzaie, Mohsen Abedini Esfahlani, Mahshid Jalalkamali, Fatemeh Seyedi, Seyed Noureddin Nematollahi-mahani
Green LED and three-dimensional (3D) scaffolds have recently received extensive attentions due to their impact on cell proliferation and differentiation. Melatonin, a circadian rhythm-regulating hormone, is involved in some physiological phenomena including testosterone biosynthesis. Lower testosterone biosynthesis results in some disorders such as puberty retarding, andropause, and muscle weakness
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Evaluation of sperm DNA fragmentation in male infertility Andrologia (IF 2.4) Pub Date : 2022-09-15 Zeynep Caliskan, Canan Kucukgergin, Gulsan Aktan, Ates Kadioglu, Gul Ozdemirler
Sperm DNA integrity could be considered a biological marker of sperm quality and may affect fertilization, embryonic development, and pregnancy outcome. The study aimed to investigate the connection between semen characteristics and sperm DNA damage in infertile patients. Standard semen analysis of 536 samples was carried out following the World Health Organization (WHO) 5th edition recommendations
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The combination of ginger and zinc supplement could improve lead-induced reproductive dysfunction by inhibiting apoptosis mediated by oxidative damage and inflammation Andrologia (IF 2.4) Pub Date : 2022-09-15 Wei Xue, Qisheng Tang, Longfei Yang
Due to the growing industry and industrialization of many urban communities, one of the dangers that threaten human life is long-term exposure to heavy metals such as lead. Lead contamination can have a detrimental effect on fertility. On the other hand, the combination of ginger and zinc supplements can be a powerful sexual enhancer. Despite extensive studies on the effect of ginger and zinc on reproduction
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A review on applications and toxicities of metallic nanoparticles in mammalian semen biology Andrologia (IF 2.4) Pub Date : 2022-09-14 Amarjeet Bisla, Mrigank Honparkhe, Neeraj Srivastava
The advent of nanotechnology since the 1950s, when the well-known physicist Richard P. Feynman talked in his famous talk about “There's plenty of room at the bottom”, has led to incredible contribution of nanotechnology in the fields of medical and veterinary therapeutics, diagnostics and other applications. Semen biology dealing with the study of spermatozoa and its related physiological and pathological
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FSH can improve semen parameters in patients with idiopathic oligoasthenoteratozoospermia: A systematic review and meta-analysis Andrologia (IF 2.4) Pub Date : 2022-09-14 Xuebao Zhang, Jie Chen, Yuanqing Cui, Yinshan Jin, Xiong Wang
Follicle-stimulating hormone (FSH) is commonly used in assisted reproductive technology to promote the development and maturation of follicles in female patients. However, there is no consensus on treating FSH in males with idiopathic oligoasthenoteratozoospermia (iOAT), especially in patients with normal serum FSH levels. To determine the role of FSH in improving semen quality in patients with iOAT
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CHD5 gene (rs9434741) might be a genetic risk factor for infertility in non-obstructive azoospermia and severe oligozoospermia Andrologia (IF 2.4) Pub Date : 2022-09-14 Nasim Naeimi, Homa Mohseni Kouchesfehani, Zahra Heidari, Hamidreza Mahmoudzadeh-Sagheb, Saeed Movahed
Inability to conceive is one of the health concerns. Chromodomain helicase DNA-binding protein5 (CHD5) gene is a major regulator in the replacement of histone proteins with protamines, the chromatin remodelling in spermatogenesis process. Thus, functional SNPs in this gene can disrupt sperm development. This study aimed to investigate the relationship between CHD5 polymorphism (rs9434741) and male
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Cryptic splice site poisoning and meiotic arrest caused by a homozygous frameshift mutation in RBMXL2: A case report Andrologia (IF 2.4) Pub Date : 2022-09-14 Farah Ghieh, Vincent Izard, Marine Poulain, Johanne Fortemps, Nadia Kazdar, Béatrice Mandon-Pepin, Sophie Ferlicot, Jean Marc Ayoubi, François Vialard
Gene expression in meiotic cells in the testis is characterized by intense transcriptional activity and alternative splicing. These processes are mainly controlled by RNA-binding proteins expressed strongly in germ cells. Functional impairments in any of these proteins' functions can lead to defects in meiosis and thus severe male infertility. Here, we have identified a homozygous frameshift mutation
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Preoperative testosterone and follicle stimulating hormone levels are important predictors for sperm retrieval by microdissection testicular sperm extraction in non-mosaic Klinefelter syndrome Andrologia (IF 2.4) Pub Date : 2022-09-13 Kei-ichiro Uemura, Toshiyuki Iwahata, Hisamitsu Ide, Akiyoshi Osaka, Ippei Hiramatsu, Kouhei Sugimoto, Hiroshi Okada, Kazutaka Saito
This study aimed to assess outcomes of microdissection testicular sperm extraction (MD-TESE) and identify predictors for sperm retrieval (SR) in patients with non-mosaic Klinefelter syndrome (NM-KFS). We retrospectively evaluated 37 patients with NM-KFS who underwent MD-TESE. Data of age at operation, body mass index (BMI), testicular volume, serum luteinizing hormone (LH), follicle stimulating hormone
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Sperm selection techniques in cattle: Microfilter device versus conventional methods Andrologia (IF 2.4) Pub Date : 2022-09-13 Jhorjhi Vega-Hidalgo, Misael Rodriguez, Deysi Dipaz-Berrocal, Josselin Rivas, Carmen Huayhua, Edwin Mellisho
Microfluidics and microfilter devices have been developed to mimic the characteristics of the female reproductive tract, minimizing the risk of sperm damage. This study aimed to compare the use of a microfilter device versus conventional methods for sperm selection used in in vitro fertilization (IVF). For selecting spermatozoa, the pooled samples were processed in a microfilter device, swim-up and