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Value of Absolute Eosinophil Count in Patients with Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention Int. J. Gen. Med. (IF 2.3) Pub Date : 2024-03-18 Yufei Wang, Xiaoteng Ma, Zhiqiang Yang, Qiuxuan Li, Yujie Zhou, Fei Gao, Zhijian Wang
Background and Aims: Elevated eosinophils typically indicate hypersensitive inflammation; however, their involvement in cardiovascular events remains incompletely understood. We investigated the association between the absolute eosinophil count (AEC) and major adverse cardiovascular and cerebrovascular events (MACCEs) in patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention
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Biomarkers in the Severity of Necrotizing Enterocolitis in Preterm Infants: A Pilot Study Int. J. Gen. Med. (IF 2.3) Pub Date : 2024-03-15 Wei Meng, Qing Wang, Qingyu Xu, Hongli Gao, Yunjun Zhou, Wei Shao
Background: The occurrence of necrotizing enterocolitis (NEC) is a common and severe disease of the digestive system in neonates. This study aims to assess the value of the intestinal tissue oxygen saturation (rintSO2) combined with the levels of procalcitonin (PCT) and mean platelet volume (MPV) in predicting the severity of NEC in preterm infants. Methods: This experiment was a retrospective cohort
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Pulmonary Manifestations of Systemic Lupus Erythematosus Among Adults in Aseer Region, Saudi Arabia Int. J. Gen. Med. (IF 2.3) Pub Date : 2024-03-15 Nouf A Alhammadi, Hanan Saeed Alqahtani, Syed Esam Mahmood, Abdulrahman Arif Alshahrani, Abdullaziz Motlaq A Alahmari, Abdullah Rashid Safer Alshahrani, Abdullah Saeed A Badawi, Ali Mohammed Ali Alqahtani, Abdullah Thabet A Alsalem, Mohammed Saeed M Alsultan Alqahtani, Mohammed Ali Gazzan
Background: Nearly half of the Systemic lupus erythematosus (SLE) patients develop lung involvement. The study assessed the extent of pulmonary involvement among SLE patients and to identify the associated factors in the population. Methodology: This retrospective cohort study was conducted at Aseer Hospital and Khamis Myshat Hospital in the Southern region of Saudi Arabia. The study spanned from January
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Prognostic Value of CRP–Albumin–Lymphocyte (CALLY) Index in Patients Undergoing Surgery for Breast Cancer Int. J. Gen. Med. (IF 2.3) Pub Date : 2024-03-15 Jiaru Zhuang, Shan Wang, Yuan Wang, Yibo Wu, Renjing Hu
Purpose: According to the 2023 global cancer data, breast cancer is the most common malignant tumor among women in the world. Its occurrence and development is influenced by inflammation, nutrition, and immune status. Therefore, this study combines C-reactive protein (CRP), albumin, and lymphocyte, which can reflect the above states, to form the CRP-albumin-lymphocyte (CALLY) index, an indicator to
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Correlation of Peripheral Blood Inflammatory Indicators to Prognosis After Intravenous Thrombolysis in Acute Ischemic Stroke: A Retrospective Study Int. J. Gen. Med. (IF 2.3) Pub Date : 2024-03-15 Tianrui Zhang, Sha Fu, Xiaofeng Cao, Yangjingyi Xia, Manyan Hu, Qinghua Feng, Yujun Cong, Yuan Zhu, Xiaogang Tang, Minghua Wu
Purpose: According to many previous studies, neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR) and hypersensitive C-reactive protein (CRP) are commonly used as important indicators to assess the prognosis of intravenous thrombolysis in AIS patients. Based on this, we used two novel biomarkers C-NLR (CRP/neutrophil-to-lymphocyte ratio) and C-LMR (CRP×lymphocyte-to-monocyte ratio)
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Research Status and Trends of Traditional Chinese Medicine Therapeutic Formulae for Coronary Heart Disease Scientometrics Research Int. J. Gen. Med. (IF 2.3) Pub Date : 2024-03-12 Mi Zhou, Jieyun Li, Xinang Xiao, Jiekee Lim, Zhikui Tian, Dongjun Wang, Naijin Zhang, Zhaoxia Xu
Aim of the Study: This study analyzes research on TCM formulae in CHD over the past 30 years, using VOSviewer and CiteSpace. It aims to highlight key trends and hotspots in the field. Materials and Methods: The core database of Web of Science was collected, and the search time range was from the establishment of the database to the present (August 2023) for the literature related to the study of TCM
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Impact of AI-Powered Solutions in Rehabilitation Process: Recent Improvements and Future Trends Int. J. Gen. Med. (IF 2.3) Pub Date : 2024-03-12 Umamah bint Khalid, Muddasar Naeem, Fabrizio Stasolla, Madiha Haider Syed, Musarat Abbas, Antonio Coronato
Abstract: Rehabilitation is an important and necessary part of local and global healthcare services along with treatment and palliative care, prevention of disease, and promotion of good health. The rehabilitation process helps older and young adults even children to become as independent as possible in activities of daily life and enables participation in useful living activities, recreation, work
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The Clinical Value of Systemic Immune Inflammation Index (SII) in Predicting the Severity of Hospitalized Children with Mycoplasma Pneumoniae Pneumonia: A Retrospective Study Int. J. Gen. Med. (IF 2.3) Pub Date : 2024-03-12 Shuye Wang, Yu Wan, Wenbo Zhang
Objective: The Systemic Immune Inflammation Index (SII), as a novel inflammation biomarker that comprehensively reflects the inflammatory and immune status of the body, has not been reported in studies on Mycoplasma pneumoniae pneumonia (MPP) in children. This study aims to investigate whether SII can serve as an effective indicator for evaluating the condition of MPP. Methods: This study recruited
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Application Value of Serum Cardiac Troponin T, Brain Natriuretic Peptide Levels and Electrocardiogram Changes in the Treatment and Prognosis Evaluation of Severe Pneumonia in Children Int. J. Gen. Med. (IF 2.3) Pub Date : 2024-03-11 Liang Deng, Xiaojun Liu, Wei Liu
Objective: To explore the application of serum cardiac troponin T (cTnT), brain natriuretic peptide (BNP) levels, and electrocardiogram changes in the treatment and prognosis evaluation of severe pneumonia in children. Methods: 120 children with severe pneumonia (severe group) admitted to our hospital from June 2020 to December 2022 were selected as the study subjects with prospective study. They were
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Oxidative Products of Catecholamines During Heightened Sympathetic Activity Due to Congestive Heart Failure: Possible Role of Antioxidants Int. J. Gen. Med. (IF 2.3) Pub Date : 2024-03-11 Paul Ganguly
Abstract: The past several decades have shown the functional status of sympathetic activity in congestive heart failure. The results, particularly through clinical and basic studies in heart failure, indicate an increased sympathetic neural activity. The definitive and compelling evidence of the involvement of catecholamines is the demonstration that many drugs that are therapeutically useful in the
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Retinoblastoma Incidence in Taiwan Over a Recent 20-Year Period: A Comprehensive Nationwide Study Int. J. Gen. Med. (IF 2.3) Pub Date : 2024-03-08 Hsin-Ying Lin, Chung-Han Ho, Yu-Shiuan Lin, Shu-Chun Kuo, Yi-Chen Chen, Yung-Jen Cheng
Purpose: Continuous advancements in medical diagnostic technology and the growing availability of resources suggest a potential for fluctuations in the incidence rate of retinoblastoma (Rb). This study aimed to analyze incidence data of Rb patients in Taiwan from 1999 to 2018, utilizing the nationwide Taiwan Cancer Registry (TCR) database. Additionally, we investigated the treatment modalities used
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Media Search Frequency, Source Credibility About e-Cigarette Health Information, and Motivation to Quit EC Among University Students in Chengdu, China Int. J. Gen. Med. (IF 2.3) Pub Date : 2024-03-08 Li Wang, Ching Sin Siau, Nizam Baharom, Mohd Izzuddin Hairol, Lixin Huang, Lei Hum Wee
Purpose: E-cigarettes (ECs) are gaining popularity among young people. This study aimed to assess university student vapers’ search frequency and source credibility of commonly used media in China, and their association with daily EC users’ motivation to quit EC use. Participants and Methods: This was a cross-sectional study involving an online quantitative survey in six universities in Chengdu, China
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JAG1 Variants Confer Genetic Susceptibility to Thyroid Dysgenesis and Thyroid Dyshormonogenesis in 813 Congenital Hypothyroidism in China Int. J. Gen. Med. (IF 2.3) Pub Date : 2024-03-07 Miaomiao Li, Xiaoyu Wang, Fang Wang, Fengqi Wang, Dehua Zhao, Shiguo Liu
Background and Objective: Congenital hypothyroidism (CH) is indeed a prevalent neonatal endocrine disorder, affecting approximately 1 in 2000– 3000 newborns worldwide, and 1 in 2400 newborns in China. Despite its high incidence, the genetic causes of CH, particularly those related to thyroid dysgenesis (TD), are still not well understood. However, previous studies have suggested that JAG1 may be a
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Exploring Symptom Clusters in Chinese Patients with Diabetic Kidney Disease: A Network Analysis Int. J. Gen. Med. (IF 2.3) Pub Date : 2024-03-07 Di-Fei Duan, Min Liu, Deng-Yan Ma, Lin-Jia Yan, Yue-Yang Huang, Yi Chen, Wei Jiang, Xi Tang, An-Qi Xiong, Yun-Ying Shi
Purpose: The research on symptom management in patients with diabetic kidney disease (DKD) has shifted from separate symptoms to symptom clusters and networks recently. This study aimed to evaluate the unpleasant symptoms of DKD patients, and to investigate how these symptom clusters could affect patients. Methods: 408 DKD patients were recruited in this cross-sectional study. The symptoms of DKD patients
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The Predictive Value of Hemoglobin to Red Cell Blood Distribution Width Ratio Combined with Serum Sodium for MACE of Acute Heart Failure with Preserved Ejection Fraction in Elderly Patients Int. J. Gen. Med. (IF 2.3) Pub Date : 2024-03-06 Xiaoye Yuan, Caixia Lv, Sisi Wu, Huiying Wang, Xiaoyu Liu
Purpose: To investigate the predictive value of hemoglobin (Hb) to red blood cell distribution width (RDW) (Hb/RDW) ratio in combination with serum sodium for major adverse cardiovascular events (MACE) in elderly acute heart failure patients with preserved ejection fraction at 30 days after discharge. Methods: 130 elderly acute heart failure patients with preserved ejection fraction were enrolled and
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Predictive Factors for First-Pass Intubation Failure in Trauma Patients Int. J. Gen. Med. (IF 2.3) Pub Date : 2024-03-06 Katherine Kilkenny, Shea McGrinder, Michael J Najac, Johnathon LeBaron, Pietro Carpenito, Nisha Lakhi
Objective: The primary objective of this study was to elucidate risk factors for multiple intubation attempts (MIA) in trauma patients requiring emergent tracheal intubation (ETI). Risk factors for mortality, intensive care unit (ICU) admission, and prolonged ventilation were assessed as secondary outcomes. The association between multiple intubation attempts and adverse outcomes has been well described
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Development and Validation of a Novel Predictive Model for the Early Differentiation of Cardiac and Non-Cardiac Syncope Int. J. Gen. Med. (IF 2.3) Pub Date : 2024-03-06 Sijin Wu, Zhongli Chen, Yuan Gao, Songren Shu, Feng Chen, Ying Wu, Yan Dai, Shu Zhang, Keping Chen
Background: The diagnosis of cardiac syncope remains a challenge. This study sought to develop and validate a diagnostic model for the early identification of individuals likely to have a cardiac cause. Methods: 877 syncope patients with a determined cause were retrospectively enrolled at a tertiary heart center. They were randomly divided into the training set and validation set at a 7:3 ratio. We
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Combining Traditional Chinese Herbs and csDMARDs for the Treatment of Rheumatoid Arthritis Involves Tapering and Discontinuing Glucocorticoids: Protocol for a Two-Stage Non-Randomized Controlled Trial Int. J. Gen. Med. (IF 2.3) Pub Date : 2024-03-05 Xingqiang Wang, Xianna Yang, Shiqi Wang, Xiaofang Tian, Jianmei Yin, Nian Liu, Pengtao Di, Jipeng Qi, Ya Li, Jimin Chen, Yang Wu, Jingjin Wu, Weiqing Zhao, Jiangyun Peng, Ling Zhang, Lingli Gu
Abstract: Glucocorticoids (GC) are crucial in the treatment of rheumatoid arthritis (RA), but discontinuing GC effectively in RA patients poses a significant challenge for rheumatologists. In this two-stage, single-center, non-randomized controlled trial, we investigated the benefits of combining Chinese traditional herbal treatment with csDMARDs to aid GC discontinuation in terms of GC tapering, disease
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The Potential Applications and Challenges of ChatGPT in the Medical Field Int. J. Gen. Med. (IF 2.3) Pub Date : 2024-03-05 Yonglin Mu, Dawei He
Abstract: ChatGPT, an AI-driven conversational large language model (LLM), has garnered significant scholarly attention since its inception, owing to its manifold applications in the realm of medical science. This study primarily examines the merits, limitations, anticipated developments, and practical applications of ChatGPT in clinical practice, healthcare, medical education, and medical research
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The Prevalence and Associated Factors of Occupational Stress in Healthcare Providers in Saudi Arabia Int. J. Gen. Med. (IF 2.3) Pub Date : 2024-03-05 Adel F Almutairi, Nasser Ali Hamdan, Saud Altheyabi, Emtinan Abdulrahman Alsaeed, Faisal S Alammari, Ala’a BaniMustafa
Background: Occupational stress is a negative physical and emotional response to job requirements, which might be caused by various factors that can harm the emotional and physical well-being of the employee. We aimed to investigate the factors and conditions associated with occupational stress. Study Design: The study was cross-sectional, conducted with the Perceived Stress Scale ten item version
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Analysis of Risk Factors and Construction of a Predictive Model for Readmission in Patients with Coronary Slow Flow Phenomenon Int. J. Gen. Med. (IF 2.3) Pub Date : 2024-03-04 Changshun Yan, Yankai Guo, Guiqiu Cao
Background: Coronary slow flow phenomenon (CSFP) is a phenomenon in which distal vascular perfusion is delayed on angiography, but coronary arteries are not significantly narrowed and there is no other organic cardiac disease. Patients with CSFP may be repeatedly readmitted to the hospital because of chest pain or other symptoms of precordial discomfort, and there is a risk of adverse events. In order
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Correlations of m6A Methylation-Related lncRNAs with the Prognosis of Papillary Thyroid Carcinoma Int. J. Gen. Med. (IF 2.3) Pub Date : 2024-03-05 Xiang Li, Zigang Ding, Yun Tong
Purpose: Papillary thyroid carcinoma (PTC) is the most common subtype of thyroid cancer. Recurrence makes the prognosis for some patients with PTC worse. Increasing evidence have suggested that N6-methyladenosine (m6A) RNA methylation plays an important role in tumorigenesis. However, the significance of m6A-related lncRNAs in the malignant progression of PTC remains unknown. In this study, we explored
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Vaccination Shortens the Negative Nucleic Acid Conversion Time of the Older Population: A Retrospective Cohort Study of 73,456 Asymptomatic and Mild Patients with COVID-19 in Shanghai Int. J. Gen. Med. (IF 2.3) Pub Date : 2024-03-04 Chaoqun Wang, Meng Yang, Guanglin Zhu, Yanyan Hu, Le Shen, Jiaona Qiu, Yi Huang, Libing Wang
Purpose: To explore the influencing factors to predict the negative nucleic acid conversion time and ORF1ab gene CT value changes in patients with asymptomatic and mild COVID-19. Patients and Methods: A total of 73,456 patients with asymptomatic and mild COVID-19 admitted to the Mobile Cabin Hospital in Shanghai from April 3 to April 23, 2022 were selected as the research objects. Epidemiological,
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A Three-Year Cross-Sectional Analysis of Depression, Anxiety, and Quality of Life in Patients with Post-COVID-19 Syndrome Int. J. Gen. Med. (IF 2.3) Pub Date : 2024-03-05 Adrian Vasile Bota, Iulia Bogdan, David Vladut Razvan, Adrian Cosmin Ilie, Raluca Tudor, Mirela Florica Indries, Andrei Nicolae Csep, Iosif Marincu
Background: This study explores the longitudinal psychosocial impact of Long-COVID syndrome, also known as Post-COVID-19 syndrome, characterized by enduring symptoms after coronavirus disease (COVID-19) infection, over the years 2020, 2021, and 2022. It aimed to examine the variations in depression, anxiety, and quality of life among Post-COVID-19 patients during these years, hypothesizing significant
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Quantitative Analysis of Multimodal MRI Markers and Clinical Risk Factors for Cerebral Small Vessel Disease Based on Deep Learning Int. J. Gen. Med. (IF 2.3) Pub Date : 2024-03-04 Zhiliang Zhang, Zhongxiang Ding, Fenyang Chen, Rui Hua, Jiaojiao Wu, Zhefan Shen, Feng Shi, Xiufang Xu
Background: Cerebral small vessel disease lacks specific clinical manifestations, and extraction of valuable features from multimodal images is expected to improve its diagnostic accuracy. In this study, we used deep learning techniques to segment cerebral small vessel disease imaging markers in multimodal magnetic resonance images and analyze them with clinical risk factors. Methods and results: We
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A Novel Radiological Scoring System for Anterior Longitudinal Ligament Injuries Int. J. Gen. Med. (IF 2.3) Pub Date : 2024-02-29 Yang Li, Yuling Sun, Ji Wu, Zhongya Gao, Youcai Qiu, Lin Han, Xuhua Lu
Background and Aim: Cervical hyperextension injury is very frequent with anterior longitudinal ligament (ALL) injury, and the ligament damage has a remarkable effect on whether and what type of operation should be performed. This study aims to establish a new scoring system for the accurate diagnosis of ALL damage. Methods: The imaging data of the consecutive patients was measured and scored by four
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Exploring the Molecular Mechanisms and Shared Gene Signatures Between Systemic Lupus Erythematosus and Bladder Urothelial Carcinoma Int. J. Gen. Med. (IF 2.3) Pub Date : 2024-02-28 Kongjia Wang, Shufei Wang, Yixin Ding, Zengshun Kou, Bo Jiang, Sichuan Hou
Background: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease associated with increased susceptibility to cancer, including bladder urothelial carcinoma (BLCA). This study investigates the shared molecular mechanisms and gene signatures between SLE and BLCA, shedding light on potential biomarkers and therapeutic targets. Methods: We compiled gene datasets related to SLE and BLCA from
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Determinants and Prognoses of Visual-Functional Mismatches After Mechanical Reperfusion in ST-Elevation Myocardial Infarction Int. J. Gen. Med. (IF 2.3) Pub Date : 2024-02-27 Jieliang Liu, Junguo Jin, Bingyan Yu, Shanghong Zhang, Xiaoqi Lu, Guoqiang Chen, Yi Yang, Haojian Dong
Background: Discordance between the anatomy and physiology of the coronary has important implications for managing patients with stable coronary disease, but its significance in ST-elevation myocardial infarction has not been fully elucidated. Methods: The retrospective study involved patients diagnosed with ST-elevation myocardial infarction (STEMI) who underwent percutaneous coronary intervention
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Predictive Value of MHR and NLR for Ulcerative Colitis Disease Activity Int. J. Gen. Med. (IF 2.3) Pub Date : 2024-02-27 Tian Liu, Zhenkun Qin, Zhiyue Yang, Xiaoling Feng
Background: Numerous non-invasive serologic tests are available to diagnose and monitor ulcerative colitis (UC), but their accuracy levels are limited. Thus, there is a pressing need for a serologic biomarker with higher precision for clinical practice. This study aims to evaluate the predictive capacity of monocyte/HDL ratio (MHR) and neutrophil/lymphocyte ratio (NLR) for UC disease activity. Patients
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Overlap Between Gastroesophageal Reflux Disease and Functional Constipation and Associated Risk Factors Among the General Population in Saudi Arabia Int. J. Gen. Med. (IF 2.3) Pub Date : 2024-02-26 Bashaeer Abdullh Al Jalal, Ahmed Khalid Alnawah, Fahad Mohammed Alturkie, Khalid Jafar Alqadhib, Mohammed Sami Alabbadi, Sayed Ibrahim Ali, Hessah Abdulaziz Al Hussaini
Introduction: Gastroesophageal reflux disease (GERD) and functional constipation (FC) are two common gastrointestinal disorders that affect many age groups in the community. A few studies were conducted to find the association between GERD and FC, but no study had been conducted in Saudi Arabia. Therefore, this study aims to find the overlap between GERD and FC and associated risk factors among the
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Vulvar Hidradenoma Papilliferum Int. J. Gen. Med. (IF 2.3) Pub Date : 2024-02-26 Lixin Wang, Gang Chen, Jingui Jiang, Guoyan Liu, Ying-Lan Tuo, Xiaohong Li, Weishan Zhang
Aim: This study examines the clinical and pathological characteristics, immune profile, histological occurrence, diagnosis, and differential diagnosis of vulvar hidradenoma papilliferum. Methods: An analysis was conducted on clinical data, histological patterns, and immunohistochemical findings from 45 cases of vulvar hidradenoma papilliferum, and relevant published articles were reviewed. Simultaneously
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Increased PD-1+ NK Cell Subset in the Older Population Int. J. Gen. Med. (IF 2.3) Pub Date : 2024-02-26 Meiju Deng, Yongqin Zeng, Ying Liu, Xiaolei Wang, Na Chen, Mengyuan Zhang, Meiqing Jiang, Hongxin Zhao, Juan Du
Background: The aging of the immune system is associated with various diseases. It is worth exploring the changes of the immune system in aging. Previous studies have shown that aged T cells have enhanced expression of co-inhibitory molecules. However, it remains unclear whether aged NK cells exhibit similar characteristics to aged T cells. The objective of our research was to clarify this aspect.
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Bioinformatics Analysis and Experimental Validation of Mitochondrial Autophagy Genes in Knee Osteoarthritis Int. J. Gen. Med. (IF 2.3) Pub Date : 2024-02-23 Kuihan Tang, Li Sun, Long Chen, Xiaobo Feng, Jiarui Wu, Hao Guo, Yong Zheng
Background: Mitochondrial autophagy is closely related to the pathogenesis of osteoarthritis, In order to explore the role of mitochondrial autophagy related genes in knee osteoarthritis (KOA) and its molecular mechanism. Methods: KOA-related transcriptome data were extracted from the Gene Expression Omnibus (GEO) database. Differentially expressed mitochondrial autophagy gene (DEMGs) were screened
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How Do We Establish the Utility and Evidence of General Medicine in Japan? Int. J. Gen. Med. (IF 2.3) Pub Date : 2024-02-22 Masaki Tago, Risa Hirata, Hiromizu Takahashi, Shun Yamashita, Masayuki Nogi, Kiyoshi Shikino, Yosuke Sasaki, Takashi Watari, Taro Shimizu
Abstract: Hospital Medicine in the United States has achieved significant progress in the accumulation of evidence. This development has influenced the increasing societal demand for General Medicine in Japan. Generalists in Japan actively engage in a wide range of interdisciplinary clinical practices, education, and management. Furthermore, Generalists have also contributed to advances in research
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Correlation Between Maternal Anxiety During Mid-Pregnancy and Subsequent Infant Sleep Issues: A Cross-Sectional Study from 2015 to 2016 Int. J. Gen. Med. (IF 2.3) Pub Date : 2024-02-21 Sumei Wang, Zhiling Cai, Guopeng Gao, Shuangqin Yan
Purpose: To explore the correlation between maternal anxiety during mid-pregnancy and infant sleep issues based on the anxiety status of mothers in mid-pregnancy. Patients and Methods: A cohort of 2122 primigravida women from Ma’anshan City, Anhui Province, was followed from pregnancy until 6 months postpartum. The study analyzed the impact of maternal anxiety on infant sleep patterns, including primary
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A Cross-Sectional Study Investigating Clinical Features, Brain Imaging, and Treatment Efficacy in Patients with Cerebral Venous Thrombosis in the Mekong Delta, Vietnam Int. J. Gen. Med. (IF 2.3) Pub Date : 2024-02-20 Minh Van Le, Tam Thai Thanh Tran, Loc Phu Huynh, Tho Kieu Anh Pham, Thi Van Vo, Hung Huynh Vinh Ly
Background: Cerebral venous thrombosis (CVT) is a challenging condition with potential long-term consequences, but it is also a treatable disorder that offers the possibility of complete recovery. This study was conducted to comprehensively investigate the clinical features, brain imaging findings, and treatment outcomes of patients diagnosed with cerebral venous thrombosis. Materials and Methods:
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A Cross-Sectional Analysis to Assess the Role of Atopy in Keratoconus Among Saudi Population [Corrigendum] Int. J. Gen. Med. (IF 2.3) Pub Date : 2024-02-19 Ismail Ibrahim Abuallut, Abeer Rihan Alomaish, Alshaymaa Mohammad Arishy, Mariam Asiri Mashragi, Kholod Hadi Alfaifi, Noura Ali Alnamazi, Aisha Mansour Moafa, Mohamed S Mahfouz, Majid A Moafa, Sultan A Jafaari, Abdulaziz A Alagsam, Hani Basher Albalawi, Mohammad A Jareebi
Corrigendum for the article A Cross-Sectional Analysis to Assess the Role of Atopy in Keratoconus Among Saudi Population
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Identification of a Novel Gene Expression Signature Associated with Amino Acid Metabolism (AAM) in Ankylosing Spondylitis (AS) Int. J. Gen. Med. (IF 2.3) Pub Date : 2024-02-19 Hao Liu, Yinxiao Peng
Background: Studies have proven that amino acid metabolism (AAM) plays an important role in ankylosing spondylitis (AS). Therefore, this study identified key AAM-related genes (AAMRGs) for the diagnosis and prediction of AS. Methods: Firstly, the differentially expressed genes (DEGs) were identified between AS and normal groups in the GSE25101 and GSE73754 datasets downloaded from the Gene Expression
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Cancer-Related Fatigue and Its Influencing Factors Among Colorectal Cancer Patients: A Generalized Linear Modeling Approach Int. J. Gen. Med. (IF 2.3) Pub Date : 2024-02-16 Song Wang, Yuanyuan Song, Huaguo Zhang, Jing Song, Xiaoyan Guo, Xiaolian Jiang
Purpose: This study aimed to improve cancer-related fatigue (CRF) and health outcomes of colorectal cancer patients by understanding the status quo of CRF, exploring the relations of coping, anxiety symptoms, depressive symptoms, body image perception and CRF, and also identifying the factors affecting CRF based on a generalized linear modeling approach. Patients and Methods: An exploratory cross-sectional
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Perioperative Risk Factors for Postoperative Pulmonary Complications After Minimally Invasive Esophagectomy Int. J. Gen. Med. (IF 2.3) Pub Date : 2024-02-15 Xiaoxi Li, Ling Yu, Miao Fu, Jiaonan Yang, Hongyu Tan
Background: Postoperative pulmonary complications (PPCs) are the most prevalent complication after esophagectomy and are associated with a worse prognosis. This study aimed to investigate the perioperative risk factors for PPCs after minimally invasive esophagectomy (MIE). Methods: Seven hundred and sixty-seven consecutive patients who underwent McKeown MIE via thoracoscopy and laparoscopy were retrospectively
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A Novel LDLC Equation is Superior to the NIH LDLC Equation and the Friedewald Equation Int. J. Gen. Med. (IF 2.3) Pub Date : 2024-02-14 Guo-Ming Zhang, Jing Liu, Xu-Xiao Guo, Fu-Meng Yang
Background: LDLC equations have varying levels of underestimation for the calculated LDLC. Therefore, underestimating LDLC should be avoided as much as possible. We need to establish LDLC equations that underestimate LDLC as little as possible. Methods: We established the equations with a healthy cohort from Shuyang Hospital and validated the equations with an unselected patient cohort from The Second
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Assessment of the Effectiveness of Ultrasound-Guided Needle Aspiration of Lactating Breast Abscesses Int. J. Gen. Med. (IF 2.3) Pub Date : 2024-02-13 Anh Tuan Tran, Dinh Minh Nguyen, Quang Hien Tran, Quang Hung Nguyen, Thu Ha Nguyen Thi, Do Quyen Tran Thi, Hong Nhung Luu, Yen Mai Do Thi
Objective: To evaluate the effectiveness of ultrasound-guided needle aspiration in treating lactating breast abscesses. Methods: This study was conducted in Bach Mai Hospital, from 6/2020 to 7/2021. Lactating patients with breast abscesses underwent ultrasound-guided aspiration followed by antibiotics therapy. Results: There were 59 lactating patients with 82 breast abscesses. Most of the abscesses
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Association of Regular Cervical Cancer Screening with Socioeconomic, COVID-19 Infection and Vaccine Status Among Japanese Population: Cohort Observational Study Int. J. Gen. Med. (IF 2.3) Pub Date : 2024-02-13 Tomohiro Mitoma, Jota Maki, Hikaru Ooba, Chikako Ogawa, Hisashi Masuyama, Takahiro Tabuchi
Purpose: Among the Organisation for Economic Co-operation and Development countries, Japan has one of the lowest cervical cancer screening coverages. Cancer screening coverage has worsened due to the coronavirus disease of 2019 (COVID-19) pandemic. This study investigated the relationship between socioeconomic background, COVID-19 infection history and vaccine status, and regular cervical cancer screening
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Traditional Chinese Medicine is Associated with the Reduction in Endpoint Events in Patients with Gouty Arthritis: Cohort Study and Association Rule Analysis Int. J. Gen. Med. (IF 2.3) Pub Date : 2024-02-13 Yiming Chen, Jian Liu, Chengzhi Cong, Yang Li, Yuedi Hu
Objective: This study aimed to evaluate the effect of traditional Chinese medicine (TCM) on endpoint events in patients with gouty arthritis (GA). Methods and Materials: A total of 2091 hospitalized GA patients were followed up by telephone, and propensity score matching (PSM) was used to reduce potential bias in the study design. Cox proportional risk model and Kaplan-Meier survival curve were utilized
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Anticardiolipin Antibody Plays a More Important Role Than Anti-β2-Glycoprotein I Antibody in Activating Complement in Patients with Lupus Nephritis Int. J. Gen. Med. (IF 2.3) Pub Date : 2024-02-09 Qiankun Zhang, Zhuoqin Ren, Jie Li, Zhengping Zou
Objective: This research aimed to explore the correlation between antiphospholipid antibodies (aPLs) and complement activation in lupus nephritis (LN) patients. Methods: A retrospective analysis was carried out on patients diagnosed with LN based on renal biopsy from June 2019 to June 2022. The study assessed levels of IgM, IgA, and IgG subtypes of anticardiolipin antibodies (aCLs) and anti-β 2-glycoprotein
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Association Between the miR-100 rs1834306 A>G Polymorphism and Susceptibility to Venous Malformation Int. J. Gen. Med. (IF 2.3) Pub Date : 2024-02-09 Guitao Wu, Xi Lin, Hua Jiang, Zhenyin Liu
Background: Venous malformation is related to genes and results in functional and morphologic anomalies. Genetic variations affecting the development of vessel endothelial cells are unclear. Therefore, this study aimed to investigate the potential value of the miR-100 rs1834306 A>G polymorphism as a marker of susceptibility to venous malformation. Methods: In this case–control study in southern Chinese
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Clinical Application of Serum Interleukin-6 Combined with Inflammatory Cytokines in the Dynamic Monitoring of Patients with Acute Cholecystitis Int. J. Gen. Med. (IF 2.3) Pub Date : 2024-02-08 Danping Shan, Qiyao Wang, Xiang Heng, Xiaoyan Wu
Objective: To investigate the dynamic fluctuations of serum interleukin-6 (IL-6), procalcitonin (PCT), and neutrophil counts in individuals diagnosed with acute cholecystitis. Additionally, the research seeks to investigate the potential clinical significance of these biomarkers in the early stages of acute cholecystitis. Methods: This retrospective cohort study included one hundred patients with acute
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Paired Box 5 (PAX5) Gene Has Diagnostic and Prognostic Potential in Nasopharyngeal Carcinoma Int. J. Gen. Med. (IF 2.3) Pub Date : 2024-02-08 Jiemei Ye, Xiaoying Huang, Weiling Qin, Pan Liang, Jun Zhao, Yinxin Ye, Huojin Ji, Xinyun Peng, Yushan Liang, Yonglin Cai
Purpose: Paired Box 5 (PAX5) is a transcription factor that is widely associated with carcinogenesis. PAX5 can maintain Epstein-Barr virus (EBV) latency in B cells, while a close association exists between EBV infection and nasopharyngeal carcinoma (NPC). However, there are very few reports on the correlation between PAX5 and NPC development. The aim of this study was to investigate the role of PAX5
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A Cross-Sectional Evaluation of Knowledge of Medicine Safety and Frequency of Reading Medication Leaflets and Its Predictors-Insights from Saudi Adults in Riyadh, Saudi Arabia [Letter] Int. J. Gen. Med. (IF 2.3) Pub Date : 2024-02-07 Griennasty Clawdya Siahaya, Joan Herly Herwawan, Fandro Armando Tasijawa
Letter for the article A Cross-Sectional Evaluation of Knowledge of Medicine Safety and Frequency of Reading Medication Leaflets and Its Predictors – Insights from Saudi Adults in Riyadh, Saudi Arabia
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ITGA11, a Prognostic Factor Associated with Immunity in Gastric Adenocarcinoma Int. J. Gen. Med. (IF 2.3) Pub Date : 2024-02-05 XiaoYing Yang, Mengda Wei, YanQing Huang, Xi Yang, ZhenMin Yuan, JunJie Huang, JunRen Wei, Lei Tian
Background: Stomach adenocarcinoma (STAD) presents a challenge given its advanced stage at diagnosis and poor prognosis. Integrin subunit alpha 11 (ITGA11) encodes alpha integrin and has been implicated in promoting tumorigenesis and development by participating in cell proliferation and invasion. However, the precise mechanism of ITGA11 in STAD remains unclear. Methods: The differences in ITGA11 expression
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Clinical and Radiological Outcomes of Halo Vest Application for Type II and III Odontoid Fractures Int. J. Gen. Med. (IF 2.3) Pub Date : 2024-02-05 Majdi Hashem, Saad Surur, Abdullah Soliman Hamad
Objective: To assess halo vest applications for type II and III odontoid fractures and to ascertain the radiological and clinical outcomes of this approach. Methods: A cross-sectional retrospective study was conducted by reviewing the medical charts of selected patients having type II and III odontoid fractures who underwent halo vest treatment at the King Saud Medical City Orthopaedic Department.
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Risk Factors and Management of Intraocular Pressure Elevation After Vitrectomy Combined with Silicone Oil Tamponade Int. J. Gen. Med. (IF 2.3) Pub Date : 2024-02-03 Lexin Ge, Na Su, Wen Fan, Songtao Yuan
Abstract: Silicone oil has emerged as the common option for intraocular tamponade during complicated retina vitrectomy. However, the postoperative elevation of intraocular pressure (IOP), influenced by numerous factors, remains a significant and frequently encountered complication that poses a potential threat to vision. Extensive research has been conducted to investigate the risk factors associated
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Patients with Hemophagocytic Lymphohistiocytosis Who Need Intensive Care Can Be Successfully Rescued by Timely Using Etoposide-Based HLH Regimens Int. J. Gen. Med. (IF 2.3) Pub Date : 2024-02-03 Kebing Lv, Xiaoye Cheng, Yulan Zhou, Min Yu, Shixuan Wang, Huimin Shen, Fei Li
Background: Hemophagocytic lymphohistiocytosis (HLH) patients who need intensive care usually have multiple organ failure and poor prognosis. However, the clinical characteristics, therapeutic efficacy and outcome in these critically ill HLH patients have remained unclear. Methods: We performed a retrospective study of 50 critically ill HLH patients from September 2013 to October 2022. Patients’ information
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Serum ACTH and Cortisol Level is Associated with the Acute Gastrointestinal Injury Grade in ICU Patients [Erratum] Int. J. Gen. Med. (IF 2.3) Pub Date : 2024-02-03 Wen Xu, Yuzhen Qiu, Hongping Qiu, Ming Zhong, Lei Li
Erratum for the article Serum ACTH and Cortisol Level is Associated with the Acute Gastrointestinal Injury Grade in ICU Patients
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Carrageenan-Containing Nasal Spray Alleviates Allergic Symptoms in Participants with Grass Pollen Allergy: A Randomized, Controlled, Crossover Clinical Trial Int. J. Gen. Med. (IF 2.3) Pub Date : 2024-02-03 Nicole Unger-Manhart, Martina Morokutti-Kurz, Petra U Zieglmayer, Patrick Lemell, Markus Savli, René Zieglmayer, Eva Prieschl-Grassauer
Purpose: Nonpharmacological, barrier-forming nasal sprays are used to manage symptoms of allergic rhinitis. We aim to evaluate the safety and effectiveness of Callergin (investigational product, IP), a nasal spray containing barrier-forming iota-carrageenan, in the treatment of allergic rhinitis (AR). Methods: In this randomized, controlled, crossover trial, adults with grass pollen allergy underwent
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SPRR1B is Related to the Immune Microenvironment and Can Be Used as a Biomarker for the Diagnosis of Psoriasis Int. J. Gen. Med. (IF 2.3) Pub Date : 2024-02-02 Siyu Hao, Jiuyi Cong, Zhiqiang Ma, Yan Xia, Yu Zhang, Nannan Tong, Jiangtian Tian, Yuzhen Li
Background: Psoriasis, a chronic inflammatory disorder with an unknown cause, significantly impacts the physical and psychological well-being of patients. However, current biomarkers related to psoriasis lack clinical specificity, sensitivity, and predictive ability. Methods: In this study, we collected skin lesion tissues from 20 psoriasis patients and 20 normal skin samples. Additionally, we obtained
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Efficacy of Fire-Needle Therapy in Improving Neurological Function Following Cerebral Infarction and Its Effect on Intestinal Flora Metabolites Int. J. Gen. Med. (IF 2.3) Pub Date : 2024-02-02 Yi-Jun Feng, Bing-Quan Wang, Lu-Lu Cao, Li-Ying Dong, Chu-Yi Zhang, Dong-Jian Hu, Zhen Zhou, Jin-Xiu Cao
Objective: This study was to investigate the mechanism of action and clinical efficacy of fire-needle therapy in improving neurological function in patients with acute cerebral infarction (identified as a wind-phlegm-blood stasis syndrome in traditional Chinese medicine). Methods: We included patients diagnosed with acute cerebral infarction (wind-phlegm-blood stasis syndrome) admitted to the Encephalopathy
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Optimizing Levothyroxine Replacement: A Precision Dosage Model for Post-Thyroidectomy Patients Int. J. Gen. Med. (IF 2.3) Pub Date : 2024-02-01 Guanghua Yang, Jiaxi Pu, Sibo Zhu, Yong Shi, Yi Yang, Jiangnan Mao, Yongkang Sun, Bin Zhao
Background: Thyroidectomy is commonly performed for benign or malignant thyroid tumors, often resulting in hypothyroidism. Levothyroxine (LT4) supplementation is crucial to maintain hormone levels within the normal range and suppress TSH for cancer control. However, determining the optimal dosage remains challenging, leading to uncertain outcomes and potential side effects. Methods: We analyzed clinical
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Analysis of Laboratory Critical Values During COVID-19 Pandemic at Tertiary Hospital in Saudi Arabia Int. J. Gen. Med. (IF 2.3) Pub Date : 2024-02-02 Mohammed A Jeraiby
Purpose: One of the most important aspects of post-analytical laboratory activity is the notification of critical results. Therefore, the aim of this study was to illustrate and analyze the prevalence of critical result values of our clinical laboratory investigations during the pandemic stages of coronavirus-19 (COVID-19) and other research pre-pandemic stages. Methods: The seven-month study was conducted
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Integrated Digital Mental Health Care: A Vision for Addressing Population Mental Health Needs Int. J. Gen. Med. (IF 2.3) Pub Date : 2024-02-01 Christopher T Lim, Cara Fuchs, John Torous
Abstract: The unmet need for mental health care continues to rise across the world. This article synthesizes the evidence supporting the components of a hypothetical model of integrated digital mental health care to meet population-wide mental health needs. This proposed model integrates two approaches to broadening timely access to effective care: integrated, primary care-based mental health services