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An Hsp70 promoter–based mouse for heat shock–induced gene modulation J. Mol. Med. (IF 4.7) Pub Date : 2024-03-16 Hangang Chen, Yangli Xie, Mei Zhang, Junlan Huang, Wanling Jiang, Ruobin Zhang, Can Li, Xiaolan Du, Hua Chen, Qiang Nie, Sen Liang, Qiaoyan Tan, Jing Yang, Min Jin, Shuo Huang, Liang Kuang, Nan Su, Huabing Qi, Xiaoqing Luo, Xiaoling Xu, Chuxia Deng, Lin Chen, Fengtao Luo
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How calorie restriction slows aging: an epigenetic perspective J. Mol. Med. (IF 4.7) Pub Date : 2024-03-08 Gyeong Min Lim, Nagarajan Maharajan, Gwang-Won Cho
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Blockade of aryl hydrocarbon receptor restricts omeprazole-induced chronic kidney disease J. Mol. Med. (IF 4.7) Pub Date : 2024-03-08 Nan Sun, Yimeng Zhang, Lin Ding, Xin An, Fang Bai, Yanjiang Yang, Kuipeng Yu, Jiahui Fan, Lei Liu, Huimin Yang, Xiangdong Yang
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Exploiting the therapeutic potential of contracting skeletal muscle-released extracellular vesicles in cancer: Current insights and future directions J. Mol. Med. (IF 4.7) Pub Date : 2024-03-07 Ana Carolina Pinto, Patrícia Tavares, Bruno Neves, Pedro F. Oliveira, Rui Vitorino, Daniel Moreira-Gonçalves, Rita Ferreira
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Physiological and pathological effects of phase separation in the central nervous system J. Mol. Med. (IF 4.7) Pub Date : 2024-03-05 Jiaxin Wang, Hongrui Zhu, Ruijia Tian, Qian Zhang, Haoliang Zhang, Jin Hu, Sheng Wang
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NLRC3 attenuates osteoclastogenesis by limiting TNFα+ Th17 cell response in osteoporosis J. Mol. Med. (IF 4.7) Pub Date : 2024-03-04 Lingyan Ren, Guangjun Liu, Yun Bai, Liling Gu, Yuan Wang, Li Sun
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Decreased circulating CTRP3 levels in acute and chronic cardiovascular patients J. Mol. Med. (IF 4.7) Pub Date : 2024-03-04 Andreas Schmid, Sabine Pankuweit, Ann-Kathrin Vlacil, Sören Koch, Benedikt Berge, Praveen Gajawada, Manfred Richter, Kerstin Troidl, Bernhard Schieffer, Andreas Schäffler, Karsten Grote
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Macrophage activation contributes to diabetic retinopathy J. Mol. Med. (IF 4.7) Pub Date : 2024-03-02 Yi Zhang, Aiyi Zhou
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Systematic and quantitative analysis of stop codon readthrough in Rett syndrome nonsense mutations J. Mol. Med. (IF 4.7) Pub Date : 2024-03-02 Dennis Lebeda, Adrian Fierenz, Lina Werfel, Rina Rosin-Arbesfeld, Julia Hofhuis, Sven Thoms
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The therapeutic effect of mesenchymal stem cells in diabetic kidney disease J. Mol. Med. (IF 4.7) Pub Date : 2024-02-29 Umm E. Habiba, Nasar Khan, David Lawrence Greene, Sabiha Shamim, Amna Umer
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The complement factor H-related protein-5 (CFHR5) exacerbates pathological bone formation in ankylosing spondylitis J. Mol. Med. (IF 4.7) Pub Date : 2024-02-29 Ji-Hyun Lee, Seung Hoon Lee, Chanhyeok Jeon, Jinil Han, Sang-Hyon Kim, Jeehee Youn, Ye-Soo Park, Tae-Jong Kim, Jong-Seo Kim, Sungsin Jo, Tae-Hwan Kim, Chang-Nam Son
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The role of regulated necrosis in diabetes and its complications J. Mol. Med. (IF 4.7) Pub Date : 2024-02-23
Abstract Morphologically, cell death can be divided into apoptosis and necrosis. Apoptosis, which is a type of regulated cell death, is well tolerated by the immune system and is responsible for hemostasis and cellular turnover under physiological conditions. In contrast, necrosis is defined as a form of passive cell death that leads to a dramatic inflammatory response (also referred to as necroinflammation)
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Targeting EphA2: a promising strategy to overcome chemoresistance and drug resistance in cancer J. Mol. Med. (IF 4.7) Pub Date : 2024-02-23 Rafaela Nasser Veiga, Alexandre Luiz Korte de Azevedo, Jaqueline Carvalho de Oliveira, Daniela Fiori Gradia
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Emerging therapeutic targets in systemic sclerosis J. Mol. Med. (IF 4.7) Pub Date : 2024-02-22
Abstract Systemic sclerosis is an autoimmune connective tissue disease which is characterised by vascular perturbations, inflammation, and fibrosis. Although huge progress recently into the underlying molecular pathways that are perturbed in the disease, currently no therapy exists that targets the fibrosis element of the disease and consequently there is a huge unmet medical need. Emerging studies
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Novel high-yield potato protease inhibitor panels block a wide array of proteases involved in viral infection and crucial tissue damage J. Mol. Med. (IF 4.7) Pub Date : 2024-02-21 Nienke Visser, Laure C. M. Herreman, Jennifer Vandooren, Rafaela Vaz Sousa Pereira, Ghislain Opdenakker, Robin E. J. Spelbrink, Maarten H. Wilbrink, Edwin Bremer, Reinoud Gosens, Martijn C. Nawijn, Heidi H. van der Ende-Metselaar, Jolanda M. Smit, Marc C. Laus, Jon D. Laman
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Systemic and local effect of oxidative stress on recurrent aphthous stomatitis: systematic review J. Mol. Med. (IF 4.7) Pub Date : 2024-02-20 Cristina Estornut, Giulia Rinaldi, María Carmen Carceller, Sergio Estornut, Martín Pérez-Leal
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Current knowledge of bone-derived factor osteocalcin: its role in the management and treatment of diabetes mellitus, osteoporosis, osteopetrosis and inflammatory joint diseases J. Mol. Med. (IF 4.7) Pub Date : 2024-02-16 Monika Martiniakova, Roman Biro, Veronika Kovacova, Martina Babikova, Nina Zemanova, Vladimira Mondockova, Radoslav Omelka
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FDA-approved disulfiram as a novel treatment for aggressive leukemia J. Mol. Med. (IF 4.7) Pub Date : 2024-02-13 Mawar Karsa, Lin Xiao, Emma Ronca, Angelika Bongers, Dayna Spurling, Ayu Karsa, Sandra Cantilena, Anna Mariana, Tim W. Failes, Greg M. Arndt, Laurence C. Cheung, Rishi S. Kotecha, Rosemary Sutton, Richard B. Lock, Owen Williams, Jasper de Boer, Michelle Haber, Murray D. Norris, Michelle J. Henderson, Klaartje Somers
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High expression of BCAT1 sensitizes AML cells to PARP inhibitor by suppressing DNA damage response J. Mol. Med. (IF 4.7) Pub Date : 2024-02-10
Abstract Previous evidence has confirmed that branched-chain aminotransferase-1 (BCAT1), a key enzyme governing branched-chain amino acid (BCAA) metabolism, has a role in cancer aggression partly by restricting αKG levels and inhibiting the activities of the αKG-dependent enzyme family. The oncogenic role of BCAT1, however, was not fully elucidated in acute myeloid leukemia (AML). In this study, we
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Etiopathogenesis of medication-related osteonecrosis of the jaws: a review J. Mol. Med. (IF 4.7) Pub Date : 2024-02-02
Abstract This study compiles the main hypotheses involved in the etiopathogenesis of medication-related osteonecrosis of the jaw (MRONJ). A narrative review of the literature was performed. The etiopathogenesis of MRONJ is multifactorial and not fully understood. The main hypothesis considers the disturbance of bone turnover caused by anti-resorptive drugs. Bisphosphonates and denosumab inhibit osteoclast
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Ubiquitination and deubiquitination in the regulation of N6-methyladenosine functional molecules J. Mol. Med. (IF 4.7) Pub Date : 2024-01-30
Abstract N6 methyladenosine (m6A) is the most prevalent RNA epigenetic modification, regulated by methyltransferases and demethyltransferases and recognized by methylation-related reading proteins to impact mRNA splicing, translocation, stability, and translation efficiency. It significantly affects a variety of activities, including stem cell maintenance and differentiation, tumor formation, immune
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Traumatic brain injury-induced disruption of the circadian clock J. Mol. Med. (IF 4.7) Pub Date : 2024-01-29 Lu-Ting Kuo, Hsueh-Yi Lu, Yi-Hsing Chen
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Evidence for alterations in lipid profiles and biophysical properties of lipid rafts from spinal cord in sporadic amyotrophic lateral sclerosis J. Mol. Med. (IF 4.7) Pub Date : 2024-01-29
Abstract Amyotrophic lateral sclerosis (ALS) is an age-dependent neurodegenerative disease affecting motor neurons in the spinal cord and brainstem whose etiopathogenesis remains unclear. Recent studies have linked major neurodegenerative diseases with altered function of multimolecular lipid-protein complexes named lipid rafts. In the present study, we have isolated lipid rafts from the anterior horn
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Circular RNAs: Regulators of endothelial cell dysfunction in atherosclerosis J. Mol. Med. (IF 4.7) Pub Date : 2024-01-24 Tengyu Jin, Haoyuan Wang, Yuelin Liu, Hebo Wang
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Altered expression of Sialyl Lewis X in experimental models of Parkinson’s disease J. Mol. Med. (IF 4.7) Pub Date : 2024-01-10 Maria João Nunes, Andreia Neves Carvalho, Alexandra I. Rosa, Paula A. Videira, Maria João Gama, Elsa Rodrigues, Margarida Castro-Caldas
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Spinal cord abnormal autophagy and mitochondria energy metabolism are modified by swim training in SOD1-G93A mice J. Mol. Med. (IF 4.7) Pub Date : 2024-01-10 Katarzyna Patrycja Dzik, Damian Józef Flis, Katarzyna Barbara Kaczor-Keller, Zofia Kinga Bytowska, Mateusz Jakub Karnia, Wiesław Ziółkowski, Jan Jacek Kaczor
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PRKAA2, MTOR, and TFEB in the regulation of lysosomal damage response and autophagy J. Mol. Med. (IF 4.7) Pub Date : 2024-01-06 Mohd Shariq, Mohammad Firoz Khan, Reshmi Raj, Nuzhat Ahsan, Pramod Kumar
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Liquid–liquid phase separation in Alzheimer’s disease J. Mol. Med. (IF 4.7) Pub Date : 2024-01-02 Qinggang Fu, Bixiang Zhang, Xiaoping Chen, Liang Chu
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The osteoporosis susceptibility SNP rs188303909 at 2q14.2 regulates EN1 expression by modulating DNA methylation and E2F6 binding J. Mol. Med. (IF 4.7) Pub Date : 2023-12-28 Ya Wang, Xinyao Huang, Qiongdan Zhang, Chen Cheng, Zixuan Qin, Li Lu, Qingyang Huang
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Phosphorylation of RGS16 at Tyr168 promote HBeAg-mediated macrophage activation by ERK pathway to accelerate liver injury J. Mol. Med. (IF 4.7) Pub Date : 2023-12-23 Miaomiao Tian, Nijin Wu, Xiaoyu Xie, Tiantian Liu, Yajing You, Shujun Ma, Hongjun Bian, Huiling Cao, Le Wang, Chenxi Liu, Jianni Qi
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A simple tool for evaluation of inflammation in psoriasis: Neutrophil-to-lymphocyte and platelet-to-lymphocyte ratio as markers in psoriasis patients and related murine models of psoriasis-like skin disease J. Mol. Med. (IF 4.7) Pub Date : 2023-12-21
Abstract Objective parameters to quantify psoriatic inflammation are needed for interdisciplinary patient care, as well as preclinical experimental models. This study evaluates neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in psoriasis patients and five murine models of psoriasis-like skin disease based on topical imiquimod application and overexpression of IL-17A under
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DSPE-PEG2000-methotrexate nanoparticles encapsulating phenobarbital sodium kill cancer cells by inducing pyroptosis J. Mol. Med. (IF 4.7) Pub Date : 2023-12-04 Fengyue Yin, Xiao Xu, Julia Qi, Mengyu Guo, Yubo Wang, Yun Wang, Roumei Ye, Qian Lin, Daowei Yang, Xuan Zhu, Jinling Wang
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TAT-W61 peptide attenuates neuronal injury through blocking the binding of S100b to the V-domain of Rage during ischemic stroke J. Mol. Med. (IF 4.7) Pub Date : 2023-12-05 Jia Liang, Hui Li, Chang‑Dong Liu, Xiao‑Yan Zhou, Yan‑Yan Fu, Xiang-Yu Ma, Dan Liu, Yu-Ling Chen, Qian Feng, Zhen Zhang, Xiang-Ru Wen, Guang Zhu, Nan Wang, Yuan-Jian Song
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Sphingolipids: drivers of cardiac fibrosis and atrial fibrillation J. Mol. Med. (IF 4.7) Pub Date : 2023-11-28 Junjie Liu, Ximao Liu, Yucheng Luo, Fangze Huang, Yu Xie, Shaoyi Zheng, Bo Jia, Zezhou Xiao
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Effects of different amosite preparations on macrophages, lung damages, and autoimmunity J. Mol. Med. (IF 4.7) Pub Date : 2023-11-28 Alain Lescoat, Riccardo Leinardi, Kévin Pouxvielh, Yousof Yakoub, Marie Lelong, Amandine Pochet, Erwan Dumontet, Nessrine Bellamri, Erwan Le Tallec, Cristina Pavan, Francesco Turci, Christophe Paris, François Huaux, Valérie Lecureur
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Comparing plasma and skin imprint metabolic profiles in COVID-19 diagnosis and severity assessment J. Mol. Med. (IF 4.7) Pub Date : 2023-11-27 Jeany Delafiori, Rinaldo Focaccia Siciliano, Arthur Noin de Oliveira, José Carlos Nicolau, Geovana Manzan Sales, Talia Falcão Dalçóquio, Estela Natacha Brandt Busanello, Adriana Eguti, Diogo Noin de Oliveira, Adriadne Justi Bertolin, Luiz Augusto dos Santos, Rocío Salsoso, Fabiana G. Marcondes-Braga, Nelson Durán, Maurício Wesley Perroud Júnior, Ester Cerdeira Sabino, Leonardo Oliveira Reis, Wagner
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IL-23 contributes to Particulate Matter induced allergic asthma in the early life of mice and promotes asthma susceptibility J. Mol. Med. (IF 4.7) Pub Date : 2023-11-23 Heung-Woo Park, Hyun Seung Lee
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The role of CD146 in renal disease: from experimental nephropathy to clinics J. Mol. Med. (IF 4.7) Pub Date : 2023-11-23 Louis Boutin, Elena Roger, Etienne Gayat, François Depret, Marcel Blot-Chabaud, Christos E. Chadjichristos
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A gene therapy targeting medium-chain acyl-CoA dehydrogenase (MCAD) did not protect against diabetes-induced cardiac pathology J. Mol. Med. (IF 4.7) Pub Date : 2023-11-21 Kate L. Weeks, Helen Kiriazis, Glenn D. Wadley, Emma I. Masterman, Nicola M. Sergienko, Antonia J. A. Raaijmakers, Adam J. Trewin, Claudia A. Harmawan, Gunes S. Yildiz, Yingying Liu, Brian G. Drew, Paul Gregorevic, Lea M. D. Delbridge, Julie R. McMullen, Bianca C. Bernardo
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CTHRC1 promotes colorectal cancer progression by recruiting tumor-associated macrophages via up-regulation of CCL15 J. Mol. Med. (IF 4.7) Pub Date : 2023-11-21 Yixin Liu, Xiangzheng Chen, Ying Xu, Tinghan Yang, Haichuan Wang, Ziqiang Wang, Zhangyong Hu, Longqi Chen, Zheng Zhang, Yangping Wu
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Metabolomics reveals that chronic restraint stress alleviates carbon tetrachloride-induced hepatic fibrosis through the INSR/PI3K/AKT/AMPK pathway J. Mol. Med. (IF 4.7) Pub Date : 2023-11-23 Shanshan Zhang, Binjie Liu, Lan Huang, Rong Zhang, Lin An, Zhongqiu Liu
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Identifying survival of pan-cancer patients under immunotherapy using genomic mutation signature with large sample cohorts J. Mol. Med. (IF 4.7) Pub Date : 2023-11-18 Liuchao Zhang, Yuanyuan Wang, Liuying Wang, Meng Wang, Shuang Li, Jia He, Jianxin Ji, Kang Li, Lei Cao
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Progress in diagnosis and treatment of Leber’s hereditary optic neuropathy J. Mol. Med. (IF 4.7) Pub Date : 2023-11-20 Qingyue Ma, Ying Sun, Ke Lei, Wenjuan Luo
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Two-trace two-dimensional correlation spectra (2T2D-COS) analysis using FTIR spectra to monitor the immune response by COVID-19 J. Mol. Med. (IF 4.7) Pub Date : 2023-11-10 Sivakumaran Karthikeyan, Gustavo J. Vazquez-Zapien, Adriana Martinez-Cuazitl, Raul J. Delgado-Macuil, Daniel E. Rivera-Alatorre, Francisco Garibay-Gonzalez, Josemaria Delgado-Gonzalez, Daniel Valencia-Trujillo, Melissa Guerrero-Ruiz, Consuelo Atriano-Colorado, Alberto Lopez-Reyes, Dante J. Lopez-Mezquita, Monica M. Mata-Miranda
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Autophagy and nuclear morphometry are associated with histopathologic features in esophageal squamous cell carcinoma J. Mol. Med. (IF 4.7) Pub Date : 2023-10-25 Ricardo Iserhard, Emily Ferreira Salles Pilar, Francine Hehn de Oliveira, Sidia Maria Callegari-Jacques, Paula Ferst, Fernanda Visioli, Antonio Barros Lopes, Patrícia Luciana da Costa Lopez, Eduardo Cremonese Filippi-Chiela
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Circulating extracellular vesicles are associated with pathophysiological condition including metabolic syndrome-related dysmetabolism in children and adolescents with obesity J. Mol. Med. (IF 4.7) Pub Date : 2023-10-24 Yoshinao Kobayashi, Akiko Eguchi, Koshi Imami, Mina Tempaku, Kiyora Izuoka, Takafumi Takase, Keigo Kainuma, Mizuho Nagao, Noriko Furuta, Motoh Iwasa, Hayato Nakagawa, Takao Fujisawa, Kenji Togashi
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Syncytin-1, syncytin-2 and suppressyn in human health and disease J. Mol. Med. (IF 4.7) Pub Date : 2023-10-19 Petra Priščáková, Michal Svoboda, Zuzana Feketová, Juraj Hutník, Vanda Repiská, Helena Gbelcová, Lajos Gergely
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Soluble LDL-receptor is induced by TNF-α and inhibits hepatocytic clearance of LDL-cholesterol J. Mol. Med. (IF 4.7) Pub Date : 2023-10-20 Mulugeta M. Zegeye, Sravya S. Nakka, Jonas S. O. Andersson, Stefan Söderberg, Liza U. Ljungberg, Ashok K. Kumawat, Allan Sirsjö
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Preferential expression of SCN1A in GABAergic neurons improves survival and epileptic phenotype in a mouse model of Dravet syndrome J. Mol. Med. (IF 4.7) Pub Date : 2023-10-11 Ana Ricobaraza, Maria Bunuales, Manuela Gonzalez-Aparicio, Saja Fadila, Moran Rubinstein, Irene Vides-Urrestarazu, Julliana Banderas, Noemi Sola-Sevilla, Rocio Sanchez-Carpintero, Jose Luis Lanciego, Elvira Roda, Adriana Honrubia, Patricia Arnaiz, Ruben Hernandez-Alcoceba
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Periostin secreted by cancer-associated fibroblasts promotes cancer progression and drug resistance in non-small cell lung cancer J. Mol. Med. (IF 4.7) Pub Date : 2023-10-13 Fumiaki Takatsu, Ken Suzawa, Shuta Tomida, Yin Min Thu, Masakiyo Sakaguchi, Tomohiro Toji, Masayoshi Ohki, Shimpei Tsudaka, Keiichi Date, Naoki Matsuda, Kazuma Iwata, Yidan Zhu, Kentaro Nakata, Kazuhiko Shien, Hiromasa Yamamoto, Akiko Nakayama, Mikio Okazaki, Seiichiro Sugimoto, Shinichi Toyooka
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Interaction between mitochondria and microbiota modulating cellular metabolism in inflammatory bowel disease J. Mol. Med. (IF 4.7) Pub Date : 2023-10-11 Misa Hirose, Priyadharshini Sekar, Mariam Wed Abdelaziz Eladham, Mohammad T. Albataineh, Mohamed Rahmani, Saleh Mohamed Ibrahim
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Dual roles of UPRer and UPRmt in neurodegenerative diseases J. Mol. Med. (IF 4.7) Pub Date : 2023-10-10 Si Xu, Haihui Liu, Chen Wang, Yu Deng, Bin Xu, Tianyao Yang, Wei Liu
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DNA origami: a tool to evaluate and harness transcription factors J. Mol. Med. (IF 4.7) Pub Date : 2023-10-09 Alexios-Fotios A. Mentis, Kostas A. Papavassiliou, Athanasios G. Papavassiliou
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Vav2 promotes ductus arteriosus anatomic closure via the remodeling of smooth muscle cells by Rac1 activation J. Mol. Med. (IF 4.7) Pub Date : 2023-10-07 Yinghui Chen, Yizhuo Wu, Weiqi Feng, Xueyang Luo, Bing Xiao, Xiaowei Ding, Yongjia Gu, Yanan Lu, Yu Yu
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E3 ubiquitin ligases in nasopharyngeal carcinoma and implications for therapies J. Mol. Med. (IF 4.7) Pub Date : 2023-10-05 Zijian Zhou, Kaifeng Zheng, Shao Zhou, Youxiong Yang, Jun Chen, Xiaofeng Jin
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The role of galectin-3 in atrial fibrillation J. Mol. Med. (IF 4.7) Pub Date : 2023-09-29 Grzegorz Procyk, Aleksandra Czapla, Kamila Jałocha, Agata Tymińska, Marcin Grabowski, Aleksandra Gąsecka
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Microdevices for cancer stem cell culture as a predictive chemotherapeutic response platform J. Mol. Med. (IF 4.7) Pub Date : 2023-09-27 Eduardo Imanol Agüero, Denise Belgorosky, Julio Israel García-Silva, Ross Booth, Betiana Lerner, Maximiliano Sebastián Pérez, Ana María Eiján
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Immunogenic necroptosis in liver diseases: mechanisms and therapeutic potential J. Mol. Med. (IF 4.7) Pub Date : 2023-09-23 Zirui Ye, Nana Zhang, Hong Lei, Huimin Yao, Jingya Fu, Nan Zhang, Lexuan Xu, Guxiang Zhou, Zhijun Liu, Yi Lv
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Potential role of mesenchymal stem cells in T cell aging J. Mol. Med. (IF 4.7) Pub Date : 2023-09-26 Xianmei Zhong, Jie Chen, Bo Wen, Xu Wu, Mingxing Li, Fukuan Du, Yu Chen, Shuai Deng, Yueshui Zhao, Jing Shen, Zhangang Xiao
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Large extracellular vesicles derived from human regulatory macrophages (L-EVMreg) attenuate CD3/CD28-induced T-cell activation in vitro J. Mol. Med. (IF 4.7) Pub Date : 2023-09-19 Martin Albrecht, Lars Hummitzsch, Rene Rusch, Christine Eimer, Melanie Rusch, Katharina Heß, Markus Steinfath, Jochen Cremer, Fred Fändrich, Rouven Berndt, Karina Zitta