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Itraconazole in human medicine and veterinary practice J. Med. Mycol. (IF 3.6) Pub Date : 2024-03-11 Yamara V Sousa, Marie G Santiago, Bianca M de Souza, Kelly M Keller, Camila S F Oliveira, Leonel Mendoza, Raquel V R Vilela, Gisele A C Goulart
Diagnosis and management of fungal infections are challenging in both animals and humans, especially in immunologically weakened hosts. Due to its broad spectrum and safety profile when compared to other antifungals, itraconazole (ITZ) has been widely used in the treatment and prophylaxis of fungal infections, both in human and veterinary medicine. The dose and duration of management depend on factors
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Antifungal activity of azoles, allylamines, and 8-hidroxiquinolines, alone and in combination, against Malassezia pachydermatis in vitro and in vivo J. Med. Mycol. (IF 3.6) Pub Date : 2024-03-11 Simone Merkel, Bruna Pippi, Paula Reginatto, Angélica R. Joaquim, Gabriella R.M. Machado, Daiane Heidrich, Marina E. Furasté, Jonnathan A. Silva, Estela J.S. Konzen, Maria Lúcia Scroferneker, Saulo F. Andrade, Alexandre M. Fuentefria, Régis A. Zanette
is often reported as the causative agent of dermatitis in dogs. This study aims to evaluate the and antifungal activity of azoles and terbinafine (TRB), alone and in combination with the 8-hydroxyquinoline derivatives (8-HQs) clioquinol (CQL), 8-hydroxyquinoline-5-(n-4-chlorophenyl)sulfonamide (PH151), and 8-hydroxyquinoline-5-(n-4-methoxyphenyl)sulfonamide (PH153), against 16 isolates. Susceptibility
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Epidemiological, clinical, diagnostic, and therapeutic features of histoplasmosis: A systematic review J. Med. Mycol. (IF 3.6) Pub Date : 2024-03-11 Adama Zida, Thierry K Guiguemdé, Marcel P Sawadogo, Chanolle Tchekounou, Ibrahim Sangaré, Sanata Bamba
Histoplasmosis is a mycosis due to a dimorphic fungus . This study aimed at providing an overview of histoplasmosis epidemiological, clinical, diagnostic, and therapeutic aspects from the last 30 years.
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Estimated burden of fungal infections in Panama J. Med. Mycol. (IF 3.6) Pub Date : 2024-02-17 Cristel Rodríguez-Vargas, Ana Alastruey-Izquierdo, David W. Denning, Ana Belén Araúz
Data published on Panamanian fungal disease are scarce, mostly case reports. To date, there is no paper that compiles the burden of fungal disease Here we estimate for the first time the incidence and prevalence of fungal diseases in Panama. Data on fungal disease were obtained from different search engines: PubMed, Google Scholar, Scielo and Lilacs. For population and at risk diseases, we used statistics
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Comparative assessment of Sensititre YeastOne and Micronaut-AM EUCAST for antifungal susceptibility testing in candidaemia isolates J. Med. Mycol. (IF 3.6) Pub Date : 2024-02-14 Florian Bélik, Corentin Deckers, Mehdi Khourssaji, Te-Din Huang, Olivier Denis, Isabel Montesinos
Antifungal susceptibility testing (AFST) is essential to ensure appropriate antifungal therapy in candidaemia. This study compared two commercial colorimetric broth microdilution tests: Sensititre YeastOne (SYO; Thermo Scientific) and Micronaut-AM EUCAST AFST (M-AM; Bruker) for the AFST of spp. A total of 74 yeast strains, including ( = 40) and non- species (NACS) ( = 34), were obtained from blood
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In vitro determination of the combination of ciclopirox and terbinafine in the treatment of dermatophytosis J. Med. Mycol. (IF 3.6) Pub Date : 2024-02-10 Bárbara da Costa, Bruna Pippi, Magda Chaves, Giovanna Agostineto, Alexandre Meneghello Fuentefria
The cases of dermatophytosis are increasing and they are associated with a higher number of therapeutic failures leading the doctor to prescribe combinations of antifungals as therapy. The objective was to evaluate the interaction of terbinafine and ciclopirox, the most commonly antifungals used in the clinic, in dermatophyte isolates. The minimum inhibitory concentrations (MIC) of ciclopirox and terbinafine
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Hormographiella aspergillata pulmonary infections: Detection and identification of the fungus using pan-fungal PCR assays and DNA sequencing J. Med. Mycol. (IF 3.6) Pub Date : 2024-02-04 Gilles Nevez, Gaelle Guillerm, Jean-Philippe Talarmin, Dorothée Quinio, Xavier Iriart, Pierre-Luc Lissillour, Schéhérazade Rezig, Marie-Sarah Fangous, Marion Ranty, Laetitia Bodenes, Cécile Aubron, Marie-Anne Couturier, Solène Le Gal
is a basidiomycete exceptionally involved in invasive fungal infections (IFI). We report a case of pulmonary infection in a 30-year-old female in a context of pancytopenia and relapsed of acute myeloid leukemia (AML). She presented with fever, thoracic pain, left pleural effusion and pneumonia, diagnosed on chest X-ray and CT-scan. Direct examination of a bronchoalveolar lavage (BAL) specimen performed
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Invasive fungal rhinosinusitis by Fusarium proliferatum/annulatum in a patient with acute myeloid leukemia: A case report and review of the literature J. Med. Mycol. (IF 3.6) Pub Date : 2024-01-27 Zeynep Cansu Caliskan, Gizem Karahan, Neslihan Koray, Yasin Gokcinar, Dolunay Gülmez, Sevtap Arikan-Akdagli, Serhat Unal, Omrum Uzun
Antifungal prophylaxis with a mold-effective agent has led to a substantial decrease in invasive infections caused by spp. in the management of patients with acute myeloid leukemia undergoing induction chemotherapy. However, difficult-to-treat infections caused by other molds, such as species may still complicate the neutropenic period. Here, we present a case of a 23-year-old woman with acute myeloid
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Synergistic activity of clioquinol with voriconazole and amphotericin B against fungi of interest in eye infections J. Med. Mycol. (IF 3.6) Pub Date : 2024-01-24 Paula Reginatto, Giovanna de Jesus Agostinetto, Mário Litieri Teixeira, Saulo Fernandes de Andrade, Alexandre Meneghello Fuentefria
Keratoplasty represents a risk factor for fungal eye infections, despites the antibacterial actives in the corneal tissue preservation means, it does not contain active substances with antifungal action. Among the most commonly associated fungal agents are the species belonging to the genera and . These agents can trigger an infectious process characterized by swift progression associated with high
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Pythium insidiosum: In vitro oomicidal evaluation of telithromycin and interactions with azithromycin and amorolfine hydrochloride J. Med. Mycol. (IF 3.6) Pub Date : 2024-01-11 Lara Baccarin Ianiski, Aline Fontanella Maciel, Ana Carolina Nolasco Colla, Caroline Quintana Braga, Luis Antônio Sangioni, Mahendra Pal, Daniela Isabel Brayer Pereira, Janio Morais Santurio, Sônia de Avila Botton
This study evaluated the repositioning of the ketolide antibacterial telithromycin (TLT) against the oomycete and verified the combination of TLT and the antimicrobials azithromycin (AZM) and amorolfine hydrochloride (AMR), which have known anti- activity. Susceptibility tests of isolates ( = 20) against the drugs were carried out according to CLSI protocol M38-A2, and their combinations were evaluated
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Lodderomyces elongisporus as causative organism of oropharyngeal infections - Two case reports J. Med. Mycol. (IF 3.6) Pub Date : 2023-12-21 Vivianny Aparecida Queiroz Freitas, Andressa Santana Santos, Ana Laura Sene Amâncio Zara, Rosiane Andrade da Costa, Cristine Chaves Barreto, Renata de Bastos Ascenço Soares, Cassia Silva de Miranda Godoy, Maria do Rosário Rodrigues Silva
We report two cases of patients with oropharyngeal infection by . The identification of the two isolates was confirmed after sequencing the ITS1 and ITS4 regions. The antifungal susceptibility test revealed low MIC values for the different antifungals tested. This is the first reported case of L. present during an oropharyngeal infection and describes the laboratory methodology employed in the diagnosis
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Cell pleomorphism and changes in the enzymatic profile of selected Candida albicans strains in interaction with Escherichia coli – pilot study J. Med. Mycol. (IF 3.6) Pub Date : 2023-12-08 Katarzyna Góralska, Szymon Lis, Ewa Brzeziańska-Lasota
Interactions between and the microbiota play an important role in maintaining the balance between commensal and pathogenic organisms. Although the exact role of bacteria in reducing the pathogenicity of yeast remains poorly understood, a few examples have been documented so far: probiotics administration effectively reduces the formation of biofilm and bacterial metabolites inhibit the formation of
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Deep-seated dermatophytosis caused by Trichophyton rubrum in patient with Becker muscular dystrophy J. Med. Mycol. (IF 3.6) Pub Date : 2023-11-26 Ilham Ouaaziz, Antoine Marchand, Sophie Leducq, Christian Mirguet, Gonzague de Pinieux, Éric Bailly, Adélaïde Chesnay, Guillaume Desoubeaux
is a common fungal pathogen that usually causes superficial infection limited to epidermis only, so called dermatophytosis. However in immunocompromised patients, dermatophytosis can be exceptionally more invasive with extensive lesions involving deep tissues and generating sometimes systemic course. We report the case of a 43-year-old heart transplanted man, who presented with multiple deep-seated
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Concurrent infection of Exophiala dermatitidis and Angiostrongylus cantonensis in central nervous system of a child with inherited CARD9 deficiency: A case report and literature review J. Med. Mycol. (IF 3.6) Pub Date : 2023-11-25 Na Ma, Yufei Zhao, Mingze Tang, Han Xia, Deyuan Li, Guoyan Lu
is a relatively common environmental black yeast with a worldwide distribution that rarely causes fungal infection. Here, we report a case of a 6-year-old girl with central nervous system (CNS) encephalitis caused by and was identified by both cerebrospinal fluid culture and metagenomic next-generation sequencing (mNGS). infection was confirmed by an enzyme linked immunosorbent assay (ELISA). Whole
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A resurgence of tinea cruris caused by Epidermophyton floccosum: An outbreak among Thai naval cadets J. Med. Mycol. (IF 3.6) Pub Date : 2023-11-25 Sumanas Bunyaratavej, Punyawee Ongsri, Pattriya Jirawattanadon, Panyapat Buranaporn, Waranyoo Prasong, Chatisa Panyawong, Akkarapong Plengpanich, Charussri Leeyaphan
A decreasing trend in tinea cruris caused by , an anthropophilic dermatophyte, has been observed. This retrospective study involved Thai naval cadets aged 18 years or older with suspected groin lesions. Both clinical evaluations and laboratory investigations were conducted. In total, 86 male participants with a median age of 19 years who presented with groin rash were enrolled in the study. Branching
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Severe kerion Celsi caused by Trichophyton quinckeanum: Severe kerion Celsi due to Trichophyton quinckeanum J. Med. Mycol. (IF 3.6) Pub Date : 2023-11-17 M. Lefranc, S. Fourmond, A. Jabet, A-C Normand, D. Girard, I. Accoceberry, F. Gabriel, L. Delhaes, S. Imbert
We report a severe case of kerion Celsi of the scalp in a previously healthy 13-year-old girl due to an emerging dermatophyte species in Europe. The species was definitely identified by DNA sequencing and the patient was successfully treated by oral terbinafine for 6 weeks.
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Amphotericin B deoxycholate instillations through nephrostomy catheter as salvage treatment of massive Nakaseomyces glabrata renal fungus balls J. Med. Mycol. (IF 3.6) Pub Date : 2023-11-17 Joseph Le Moulec, Léa Picard, Sorya Belaz, Audrey Couturier, Matthieu Revest, Pierre Tattevin, David Luque-Paz
Abstract not available
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Screening of alkaloids and withanolides isolated from Solanaceae plants for antifungal properties against non-wild type Sporothrix brasiliensis J. Med. Mycol. (IF 3.6) Pub Date : 2023-11-08 Stefanie Bressan Waller, Márcia Kutscher Ripoll, Renata Marques Pierobom, Paulo Ricardo Centeno Rodrigues, Paula Priscila Correia Costa, Francisco das Chagas Lima Pinto, Otília Deusdênia Loiola Pessoa, Angelita dos Reis Gomes, Renata Osório de Faria, Marlete Brum Cleff
Antifungal resistance has often been found in animal sporotrichosis in Southern Brazil. The biological potential of compounds from plants of the Solanaceae family against infectious diseases is known, however, it is still unknown against . This study evaluated the anti- activity, synergism, cytotoxicity, and action mechanism of steroidal lactones (withanolides) and alkaloids isolated from these plants
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Extensive primary cutaneous fusariosis in a patient with burns: A case report and review of the literature J. Med. Mycol. (IF 3.6) Pub Date : 2023-11-07 Ju-Shao Yen, Shu-Ying Chang, Pei-Lun Sun
species can cause a broad spectrum of human infections, ranging from superficial and locally invasive to disseminated, depending on the immune status of the host and portal of entry. Although several cases of cutaneous fusariosis in burn victims have been reported, molecular identification for pathogen recognition has been used only in a few cases. In this report, we describe an uncommon case of extensive
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Fungal diseases in Africa: Closing the gaps in diagnosis and treatment through implementation research and advocacy J. Med. Mycol. (IF 3.6) Pub Date : 2023-10-19 Felix Bongomin, Bassey E. Ekeng, Richard Kwizera, Jon Salmanton-García, Winnie Kibone, Norman van Rhijn, Nelesh P. Govender, David B. Meya, Iriagbonse I. Osaigbovo, Davidson H. Hamer, Rita Oladele, David W. Denning
Fungal diseases impose an escalating burden on public health in Africa, exacerbated by issues such as delayed diagnosis, inadequate therapy, and limited access to healthcare resources, resulting in significant morbidity and mortality. Effectively tackling these challenges demands a comprehensive approach encompassing research, training, and advocacy initiatives. Recent clinical mycology surveys conducted
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In-vivo efficiency of the novel azole compounds (ATTAF-1 and ATTAF-2) against systemic candidiasis in a murine model J. Med. Mycol. (IF 3.6) Pub Date : 2023-09-29 Hamed Fakhim, Afsane Vaezi, Hamid Morovati, Azadeh Bandegani, Kiana Abbasi, Saeed Emami, Davood Nasiry, Seyedeh Mahdieh Hashemi, Fatemeh Ahangarkani, Hamid Badali
Background Antifungal resistance is the main health concern in the control of invasive fungal infections. This research was designed to further assess the antifungal activity of aryl-1,2,4-triazole-3-ylthio analogs of fluconazole (ATTAFs) against Candida albicans systemic candidiasis in the murine model. Materials & methods The murine model of systemic candidiasis was designed via the inoculation of
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Miltefosine repositioning: A review of potential alternative antifungal therapy J. Med. Mycol. (IF 3.6) Pub Date : 2023-09-20 Cristina de Castro Spadari, Luana Pereira Borba-Santos, Sonia Rozental, Kelly Ishida
Fungal infections are a global health problem with high mortality and morbidity rates. Available antifungal agents have high toxicity and pharmacodynamic and pharmacokinetic limitations. Moreover, the increased incidence of antifungal-resistant isolates and the emergence of intrinsically resistant species raise concerns about seeking alternatives for efficient antifungal therapy. In this context, we
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Assessing the impact of prophylactic anidulafungin during remission induction of acute myeloid leukemia – A propensity-score matching analysis J. Med. Mycol. (IF 3.6) Pub Date : 2023-09-02 Wellington Fernandes da Silva, Fernanda Rodrigues Mendes, Raphael da Costa Bandeira de Melo, Elvira Deolinda Rodrigues Pereira Velloso, Vanderson Rocha, Eduardo Magalhaes Rego
Introduction Invasive fungal infection (IFI) accounts for substantial morbidity during the treatment of acute myeloid leukemia (AML) in adults. Antifungal prophylaxis (AP) is needed during intensive chemotherapy, and posaconazole is not widely available. In this study, we aimed to examine the impact of prophylactic anidulafungin during intensive AML remission induction. Methods This is a retrospective
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Clinical outcomes of aspergillosis among paediatric and adult inpatients: A multicentre study in a Brazilian metropolitan area J. Med. Mycol. (IF 3.6) Pub Date : 2023-09-05 Antonio Camargo Martins, Eliane Molina Psaltikidis, Tiago Cristiano de Lima, Renata Fagnani, Hellen Caroline Alves Caldeira Gomide, Flavio Henrique Gilli, Angelica Zaninelli Schreiber, Lucieni de Oliveira Conterno, Tetsuhiro Matsuzawa, Akira Watanabe, Katsuhiko Kamei, Silvia Regina Brandalise, Plinio Trabasso, Mariângela Ribeiro Resende, Maria Luiza Moretti
Background Invasive Aspergillosis (IA) is a disease of significant clinical relevance, especially among immunosuppressed patients, and is associated with high mortality rates. In this study, we evaluated the epidemiological features and clinical outcomes in children and adults with IA. Methods This was an observational, multicentre, prospective surveillance study of inpatients with IA at two different
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Antifungal activity of selective serotonin reuptake inhibitors against Cryptococcus spp. and their possible mechanism of action J. Med. Mycol. (IF 3.6) Pub Date : 2023-08-30 Cecília Rocha da Silva, Livia Gurgel do Amaral Valente Sá, Thais Lima Ferreira, Amanda Cavalcante Leitão, Vitória Pessoa de Farias Cabral, Daniel Sampaio Rodrigues, Amanda Dias Barbosa, Lara Elloyse Almeida Moreira, Hugo Leonardo Pereira Filho, João Batista de Andrade Neto, Maria Erivanda França Rios, Bruno Coêlho Cavalcanti, Hemerson Iury Ferreira Magalhães, Manoel Odorico de Moraes, Hélio Vitoriano
Fungal infections caused by Cryptococcus spp. pose a threat to health, especially in immunocompromised individuals. The available arsenal of drugs against cryptococcosis is limited, due to their toxicity and/or lack of accessibility in low-income countries, requiring more therapeutic alternatives. Selective serotonin reuptake inhibitors (SSRIs), through drug repositioning, are a promising alternative
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Autochthonous case of Trichophyton indotineae in Kuwait J. Med. Mycol. (IF 3.6) Pub Date : 2023-09-01 Yousef Dashti, Khaled Alobaid, Shahad Al-Rashidi, Maryam Dashti, Moustafa Hussain AbdulMoneim, Manar Al-Enezi, Nissrine Abou-Chakra, Karin Meinike Jørgensen
Trichophyton indotineae is an emerging dermatophyte that has remarkable impact on public health worldwide. In addition to producing severe extensive skin lesions, this species is frequently resistant to terbinafine, used as a first line agent. As a result, the infection is often refractory, making treatment very challenging. The current report describes the first case of Trichophyton indotineae infection
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Systemic aspergillosis associated with acute enterocolitis in foals J. Med. Mycol. (IF 3.6) Pub Date : 2023-09-02 Mariana Rodrigues Trápaga, Vanice Rodrigues Poester, Mariana Andrade Mousquer, Rafaela Pinto de Souza, Leandro Américo Rafael, Josiane Bonel, Aryse Martins Melo, Angelita Gomes Reis, Renata Osorio de Faria, David A. Stevens, Carlos Eduardo Wayne Nogueira, Melissa Orzechowski Xavier
Aspergillosis is an uncommon disease in horses, but it can be fatal. We report two cases of systemic aspergillosis in foals that occurred in a short period in the same region of southern Brazil. In addition, a literature review of similar cases was also performed. Risk factors were attributed to an immunodepression by primary enterocolitis and corticosteroid treatment, the damage in the epithelium
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Generation of protoplasts provides a powerful experimental research tool for biological and pathogenicity studies of Pythium insidiosum J. Med. Mycol. (IF 3.6) Pub Date : 2023-08-30 Pattarana Sae-Chew, Thidarat Rujirawat, Tassanee Lohnoo, Wanta Yingyong, Yothin Kumsang, Penpan Payattikul, Nichapat Yurayart, Chompoonek Yurayart, Theerapong Krajaejun
Introduction Pythiosis is a high-mortality infectious condition in humans and animals. The etiologic agent is Pythium insidiosum. Patients present with an ocular, vascular, cutaneous/subcutaneous, or gastrointestinal infection. Antifungal medication often fails to fight against P. insidiosum. The effective treatment is limited to radical surgery, resulting in organ loss. Fatal outcomes are observed
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Correlation of antifungal susceptibility and sequence types within Cryptococcus neoformans VNI from HIV patients, and ERG11 gene polymorphism J. Med. Mycol. (IF 3.6) Pub Date : 2023-08-25 Bive Zono Bive, Rosalie Sacheli, Celestin Nzanzu Mudogo, Pius Kabututu Zakayi, Sébastien Bontems, Georges Mvumbi Lelo, Marie-Pierre Hayette
Introduction Here we tested the correlation between minimum inhibitory concentrations (MICs) of major antifungal agents and sequence types (STs) within Cryptococcus neoformans VNI isolates, and explored the ERG11 gene of included strains. Materials and methods We analysed 23 C. neoformans strains categorised into two groups according to the distribution of the ST profile in Kinshasa clinics (Democratic
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Identification, molecular characterization, and antifungal susceptibility of Cyberlindnera fabianii strains isolated from urinary tract J. Med. Mycol. (IF 3.6) Pub Date : 2023-08-28 Fatma Mutlu Sariguzel, Gamze Kalin Unuvar, Osman Kucukoglu, Omur Mustafa Parkan, Ayse Nedret Koc
Objectives Cyberlindnera fabianii is an opportunistic pathogen isolated from clinical specimens. It can be incorrectly identified as Candida utulis by phenotypic methods. This study aimed to accurately identify Cy.fabianii strains isolated from the urinary tract, and to determine their molecular characterization and antifungal susceptibilities as well. Methods Twenty-nine yeast strains isolated from
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Interest of a metabolic approach using the calScreenerTM technology to detect Candida in the peritoneal fluid: a pilot study J. Med. Mycol. (IF 3.6) Pub Date : 2023-08-01 Emmanuel Novy, Marie Collot, Paul Chevallier, Lisiane Cunat, Marie Machouart
Abstract not available
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Synergistic effect of chlorhexidine and azoles on candida biofilm on titanium surface J. Med. Mycol. (IF 3.6) Pub Date : 2023-07-23 Heng Zhang, Xuesong Yi, Mei Chen, Haiyan Shi, Lihua Tan, Hougen Lu, Yi Sun, Fei Yang
Background Candida infections of orthopedic implants are one of the most detrimental orthopedic implant-related complications with unsuccessful treatment and a poor prognosis. Most orthopedic Candida infections form biofilms and have resistance to the commonly used antifungal agents. This study aimed to develop a novel combination of normally prescribed drugs against Candida biofilm on orthopedic implants
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Ibrutinib and tracheal mucormycosis: A case report and systematic review of literature J. Med. Mycol. (IF 3.6) Pub Date : 2023-07-23 Vikram Damaraju, Ritesh Agarwal, Inderpaul Singh Sehgal, Alka Khadwal, Amanjit Bal, Shivaprakash Mandya Rudramurthy, Valliappan Muthu
Ibrutinib, a Bruton tyrosine kinase (BTK) inhibitor, has been approved for various hematological malignancies. Invasive aspergillosis is a known complication of ibrutinib, but mucormycosis is rare. We describe the case of a 70-year-old man with mantle cell lymphoma infiltrating the trachea, managed with a tracheobronchial stent and ibrutinib. He had improved one month after treatment, and we removed
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Direct antimicrobial effects of chemokines on Cryptococcus spp, with special emphasis on a ‘CXC’ chemokine J. Med. Mycol. (IF 3.6) Pub Date : 2023-07-21 Arpita Singh, Sunit K. Singh
Cryptococcus species are ingenious human pathogens that are widespread globally. They continue to cause over 200,000 deaths per year. Presently due to the rise in resistance and therapy failure, it is necessary to shift the focus to an alternate therapeutic strategy against this pathogen. One promising approach is to emphasize the host defense system in order to develop more precise and customized
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Performances of disk diffusion method for determining triazole susceptibility of Aspergillus species: Systematic review J. Med. Mycol. (IF 3.6) Pub Date : 2023-07-11 Isidore W. Yerbanga, Seydou Nakanabo Diallo, Toussaint Rouamba, Agustin Resendiz-Sharpe, Katrien Lagrou, Olivier Denis, Hector Rodriguez-Villalobos, Isabel Montesinos, Sanata Bamba
The therapeutic management of invasive aspergillosis should be guided by antifungal susceptibility testing (AFST). The disk diffusion (DD) method due to its simplicity and low cost could be an appropriate alternative to the reference methods (CLSI, EUCAST) which are not suitable for AFST in routine clinical microbiology laboratories, particularly in resource-constrained settings. This review summarizes
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Comparative analysis of onychomycosis in Puerto Rico using molecular and conventional approaches J. Med. Mycol. (IF 3.6) Pub Date : 2023-07-06 Frances Marin-Maldonado, Alba L. Pacheco-Torres, Erik Gustafson
Onychomycosis is the most prevalent nail ailment in adults, accounting for 50% of all nail infections. Dermatophyte fungi are the primary cause, but non-dermatophyte molds (NDM) and yeasts can also cause onychomycosis. It remains important to precisely determine the fungal cause of onychomycosis since the response to current treatments may vary between fungal classes. Real-time polymerase chain reaction
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In silico and in vitro analysis of the mechanisms of action of nitroxoline against some medically important opportunistic fungi J. Med. Mycol. (IF 3.6) Pub Date : 2023-06-30 Magda Antunes de Chaves, Bárbara Souza da Costa, Jade André de Souza, Mateus Alves Batista, Saulo Fernandes de Andrade, Lorane Izabel da Silva Hage-Melim, Maxwell Abegg, Marcela Silva Lopes, Alexandre Meneghello Fuentefria
The increasing resistance to antifungal agents associated with toxicity and interactions turns therapeutic management of fungal infections difficult. This scenario emphasizes the importance of drug repositioning, such as nitroxoline – a urinary antibacterial agent that has shown potential antifungal activity. The aims of this study were to discover the possible therapeutic targets of nitroxoline using
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Four uncommon clinical fungi, Lodderomyces elongisporus, Kodamaea ohmeri, Cyberlindnera fabianii and Wickerhamomyces anomalus, isolated in superficial samples from Côte d'Ivoire J. Med. Mycol. (IF 3.6) Pub Date : 2023-06-23 Ama Valérie BONOUMAN IRA, Donika KRASTEVA, Francis KOUADJO, Fréderic ROGER, Virginie BELLET, David KOFFI, Cyrille POTTIER, Offianan André TOURE, Pascal DRAKULOVSKI, Aliko Joseph DJAMAN, Stéphane RANQUE, Sébastien BERTOUT
Aims The rare yeast species Lodderomyces elongisporus, Kodamaea ohmeri, Cyberlindnera fabianii, and Wickerhamomyces anomalus are increasingly implicated in severe mycoses in immunocompromised patients. This study aimed to assess the prevalence of uncommon yeast species in Côte d'Ivoire. Methods The yeast isolates from superficial samples, mainly vaginal swabs, were collected at the Pasteur Institute
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Antifungal activity of novel azetidine tethered chitosan synthesized via multicomponent reaction approach J. Med. Mycol. (IF 3.6) Pub Date : 2023-06-15 P. Shukla, D. Deswal, A.K. Narula
The increasing incidences of fungal infections among Covid-19 infected patients is a global public concern and urgently demands novel antifungals. Biopolymers like chitosan hold unique structural properties and thus can be utilized in the synthesis of biologically important scaffolds. To address the current scenario, the author's synthesized novel chitosan-azetidine derivative by adopting one-pot multicomponent
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Evaluation of knowledge and experience of fungal infections (mycoses) among clinical doctors in Senegal J. Med. Mycol. (IF 3.6) Pub Date : 2023-06-03 Khadim Diongue, Boubou Dembélé, Mouhamadou Ndiaye, Mame Cheikh Seck, Mamadou Alpha Diallo, Aïda Sadikh Badiane, Daouda Ndiaye, Stéphane Ranque
In order to assess the knowledge and experience of fungal infections (FIs) among clinicians in Senegal, a cross-sectional survey was carried out among medical practitioners in Senegal via a questionnaire designed with “Google Forms” between 24 January and 24 April 2022. A total of 100 clinicians responded to the questionnaire. Clinicians in the 31– 40-year-old age group formed the majority of respondents
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Cryptococcal meningoencephalitis: Risk factors associated to death in a hospital in Northeastern Brazil J. Med. Mycol. (IF 3.6) Pub Date : 2023-05-30 Lisandra Serra Damasceno, Renan Carrasco Cézar, Miriam Cristina da Silva Canuto, José de Paula Barbosa Neto, Terezinha do Menino Jesus Silva Leitão
Introduction Cryptococcosis is an opportunistic systemic mycosis caused by pathogenic encapsulated yeasts of the genus Cryptococcus. The objective of the present study was to evaluate the risk factors associated with death of patients diagnosed with meningitis due to Cryptococcus spp. Methods This retrospective cohort study included patients admitted to the São José Hospital (SJH) with Cryptococcal
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Reversal of uniocular blindness with corticosteroids in a solid organ transplant recipient with cryptococcal meningitis and immune reconstitution syndrome (IRIS): A case report J. Med. Mycol. (IF 3.6) Pub Date : 2023-05-13 Praveen Tirlangi, Hari Priya Reddy Challa, Sai Ram Keithi-Reddy, Venkata Krishna Chaitanya Koduri, R Sujith Reddy, Murthy NLN Arumilli, L Siva Kumar Reddy, Gayatri Senapathy
Cryptococcal meningitis is a life-threatening infection commonly seen in patients with advanced HIV infection and solid organ transplant recipients. We report a case of cryptococcal meningitis with immune reconstitution syndrome (IRIS) who presented to us with a headache and complete loss of vision in the left eye. He was managed with antifungals and a short course of steroids, and he regained vision
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COVID-19-associated mucormycosis in India: Why such an outbreak? J. Med. Mycol. (IF 3.6) Pub Date : 2023-05-09 Gregoire Pasquier
An unprecedented mucormycosis outbreak occurred in India during the second COVID-19 wave in spring 2021. COVID-19-associated mucormycosis (CAM) was observed, mainly rhino-orbito-cerebral mucormycosis (ROCM), in patients with poorly controlled diabetes and treated with inappropriate doses of glucocorticoids. The aim of this mini-review was to compare the characteristics of the CAM epidemic in India
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Allergic bronchopulmonary aspergillosis: A multidisciplinary review J. Med. Mycol. (IF 3.6) Pub Date : 2023-05-04 Amytis Roboubi, Camille Audousset, Émilie Fréalle, Anne-Laure Brun, François Laurent, Joana Vitte, Geoffrey Mortuaire, Guillaume Lefevre, Jacques Cadranel, Cécile Chenivesse
Allergic bronchopulmonary aspergillosis (ABPA) is a rare disease characterized by a complex allergic inflammatory reaction of airways against Aspergillus affecting patients with chronic respiratory diseases (asthma, cystic fibrosis). Exacerbation is often the way to diagnose ABPA and marks its evolution by its recurrent character leading to cortico-requirement or long-term antifungal treatment. Early
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Are polar extracts and essential oil from Origanum vulgare Linn. (oregano) an alternative against itraconazole-resistant dermatophytes from veterinary cases? J. Med. Mycol. (IF 3.6) Pub Date : 2023-04-26 Stefanie Bressan Waller, Márcia Kutscher Ripoll, Luciéle Pereira de Melo, Patrícia Lindemann, Angelita dos Reis Gomes, Otávia de Almeida Martins, Marlete Brum Cleff, João Roberto Braga de Mello, Renata Osório de Faria, Mário Carlos Araújo Meireles
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The management and outcome of cryptococcosis in patients with different immune statuses and treatment protocols: A multicenter real-world study in Jiangsu Province - China J. Med. Mycol. (IF 3.6) Pub Date : 2023-04-21 Yu Wang, Yu Gu, Kunlu Shen, Xuefan Cui, Rui Min, Siqing Sun, Chunlai Feng, Yanbin Chen, Li Wang, Guoer Ma, Bilin Chen, Yueyan Ni, Huanhuan Zhong, Yi Shi, Xin Su
Objective The incidence of cryptococcosis is increasing in non-immunocompromised patients. However, the evidence on proper management is inadequate in this population. We conducted this multi-center real-world study in pulmonary cryptococcosis patients with different immune statuses, so as to provide practical evidence for optimized clinical management of cryptococcosis, especially for mild-to-moderate
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Cryptococcal meningitis in a non-HIV patient with solid organ transplantation J. Med. Mycol. (IF 3.6) Pub Date : 2023-04-21 Mediha Ugur, Sinan Cetin, Emel Uzunoglu, Mustafa Saglam, Fatma Mutlu, Ayse Nedret Koc
Cryptococcal meningitis (CM) is often associated with human immunodeficiency virus (HIV). Recently, this microorganism has been increasingly identified in HIV-negative patients. CM cases are encountered in HIV-negative individuals, especially secondary to liver disease, solid organ transplantation (SOT), tuberculosis, lymphoproliferative diseases with T-cell-mediated immunological disorders, long-term
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A previously unreported case of suppurative thrombophlebitis due to Clavispora lusitaniae J. Med. Mycol. (IF 3.6) Pub Date : 2023-04-21 Toru Yoneda, Takayuki Hoshina, Tomofumi Fukuda, Nao Ohama, Saori Murakawa, Koichi Kusuhara
We report a case with Clavispora lusitaniae-induced purulent thrombophlebitis. The patient had multiple risk factors for the development of fungal thrombophlebitis including surgical procedure, mechanical ventilation, admission to intensive care unit, total parenteral nutrition and long-term antimicrobial therapy in addition to the insertion of central venous catheter. The symptoms finally improved
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Changes in the fungal nomenclature: Why and how to manage? J. Med. Mycol. (IF 3.6) Pub Date : 2023-04-13 C. Hennequin, A. Coste, C. Imbert
Abstract not available
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Fungemia due to rare non-Candida yeasts between 2018 and 2021 in a Greek tertiary care university hospital J. Med. Mycol. (IF 3.6) Pub Date : 2023-04-04 Anastasia Spiliopoulou, Alexandra Lekkou, Georgia Vrioni, Lydia Leonidou, Massimo Cogliati, Myrto Christofidou, Markos Marangos, Fevronia Kolonitsiou, Fotini Paliogianni
Introduction Non-Candida yeasts, although rare, are increasingly encountered and recognized as a growing threat. Methods Cases of bloodstream infections (BSIs) due to non-Candida yeasts (NCYs) during the last four years (2018–2021) are presented. Results During the study period, 16 cases caused by non-Candida yeasts out of 400 cases of yeast BSIs were recorded, corresponding to an incidence of 4%.
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Instillation of Amphotericin B by bronchoscopy combined with systemic voriconazole in advanced non-small cell lung cancer patients with chronic cavitary pulmonary aspergillosis: A case series and literature review J. Med. Mycol. (IF 3.6) Pub Date : 2023-04-05 Hongxia Wu, Xiaofeng Xiong, Qingbing Han, Kaiquan Zhuo, Ke Wang, Deyun Cheng
Although the treatment of aspergillosis has been studied for years, the optimal nonsurgical treatment of chronic cavitary pulmonary aspergillosis (CCPA) remains unsatisfactory, especially in lung cancer. We report two advanced non-small cell lung cancer (NSCLC) patients who recovered from CCPA following instillation of Amphotericin B (AmB) by bronchoscopy combined with systemic voriconazole. The first
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Fungal keratitis caused by Coniochaeta mutabilis—A case report J. Med. Mycol. (IF 3.6) Pub Date : 2023-03-29 Jadesola Oremosu, Lawson Ung, James Chodosh, Connie Cañete-Gibas, Nathan P. Wiederhold, Emma C. Davies, Paulo J.M. Bispo
We present a rare case of recalcitrant fungal keratitis caused by Coniochaeta mutabilis, successfully managed with a course of oral, topical, intrastromal, and intracameral antifungals. A 57-year-old male on their fourth week of treatment for presumed left herpes simplex keratitis presented to clinic with severe left-sided foreign body sensation after gardening in his yard. On examination, a white
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Fusarium solani species complex infection treated with posaconazole in a liver transplantation patient; a case report J. Med. Mycol. (IF 3.6) Pub Date : 2023-03-31 Vildan Avkan Oguz, Nilgun Karabicak, Caglar Irmak, Tarkan Unek
Although Fusarium spp. rarely cause infections in healthy people, they can cause fusariosis, particularly in neutropenic hematological malignancies, bone marrow transplant patients, and immunocompromised patients, such as those with acquired immune deficiency syndrome (AIDS), and rarely in solid organ transplant recipients. Here, we present a case of a liver transplant recipient with F. solani species
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In vitro antifungal and antibiofilm activities of auranofin against itraconazole-resistant Aspergillus fumigatus J. Med. Mycol. (IF 3.6) Pub Date : 2023-03-28 Peiying Chen, Jing Yang, Yuanling Jin, Chujie Lu, Zhenzhen Feng, Fei Gao, Yuan Chen, Fuling Wang, Zhuo Shang, Wei Lin
Background : Infections caused by azole-resistant Aspergillus are a rising public health threat with high mortality rates, high treatment costs and limited available antifungals, indicating an urgent need for new antifungals or strategies. Our aim was to investigate antifungal and antibiofilm activities of auranofin, an FDA-approved anti-antirheumatic drug. Methods : Fungal susceptibility testing for
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Trichophyton indotineae, from epidemiology to therapeutic J. Med. Mycol. (IF 3.6) Pub Date : 2023-03-29 Arnaud Jabet, Anne-Cécile Normand, Sophie Brun, Eric Dannaoui, Claude Bachmeyer, Renaud Piarroux, Christophe Hennequin, Alicia Moreno-Sabater
Trichophyton indotineae is a newly described dermatophyte species. This fungal pathogen has recently emerged in India and is responsible for chronic or recurrent widespread superficial infections. Resistance to terbinafine is frequently associated to this pathogen and is related to point mutations in the gene encoding the squalene epoxidase. T. indotineae infections have been reported outside India
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Invasive Cerebral Aspergillosis in Non-Neutropenic Patients: A Case Series from Western India J. Med. Mycol. (IF 3.6) Pub Date : 2023-03-28 Subhashree Samantaray, Deepak Kumar, Durga Shankar Meena, Gopal Krishana Bohra, R Akshatha, Vidhi Jain, Sarbesh Tiwari, T Balamurugan, Naresh Midha, Mahendra Kumar Garg
Purpose : Invasive cerebral aspergillosis (ICA) is a rare but fatal infection affecting neutropenic immunocompromised patients. Recently cases have been reported in non-neutropenic settings also. We hereby present a series of ICA cases in non-neutropenic patients diagnosed at our tertiary care centre in Western India between March to October 2021. Methods : All patients with clinico-radiological suspicion
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Role of the mycological diagnosis in the management of tinea capitis: French recommendations in the post-griseofulvin era J. Med. Mycol. (IF 3.6) Pub Date : 2023-03-20 Jean-Pierre Gangneux, Sophie Brun, Jean Menotti, Françoise Botterel
Abstract not available
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Detection of Pneumocystis jirovecii by PCR in patients with lung cancer: A preliminary study J. Med. Mycol. (IF 3.6) Pub Date : 2023-02-27 Ozlem Ulusan Bagci, Filiz Guldaval, Can Muftuoglu, Ufuk Mert, Seray Toz, Damla Serce Unat, Omer Selim Unat, Gulru Polat, Ayse Caner
Introduction Infection complications in lung cancer (LC), one of the most common cancers in the world, are still among the most important causes of death. Of them, P. jirovecii, which is as an opportunistic infection, causes a life-threatening type of pneumonia in cancer patients. This preliminary study aimed to determine the incidence and clinical status of P. jirovecii by PCR in lung cancer patients
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Review: The application of corticosteroids in cryptococcal meningitis J. Med. Mycol. (IF 3.6) Pub Date : 2023-02-24 Junyu Liu, Jia Liu, Lu Yang, Xiaofeng Xu, Qin Bang-e, Ying Jiang, Fuhua Peng
Cryptococcal meningitis (CM) is a serious disease with high morbidity and mortality. Although the patients who received corticosteroids were at high risk of having CM, corticosteroids also have been used as an adjunct to antifungal drugs for treating people with CM in some situations (such as immune reconstitution inflammatory syndrome, cerebral cyptococcoma, et al.). Here, we summarize the current