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Light chain deposition disease presenting with gastrointestinal disorder as primary manifestation: report of two cases and literature review J. Int. Med. Res. (IF 1.6) Pub Date : 2024-03-15 Chenxiang Wei, Min Wang, Jiamin Li, Jiajun Su, Jing Huang, Sunwing Tong, Dongye Yang
Light chain deposition disease (LCDD) is an under-recognized condition characterized by deposition of abnormal monoclonal light chains in tissues, leading to organ dysfunction. LCDD involving the gastrointestinal tract is very uncommon, and its diagnosis is challenging. We herein report two cases of LCDD that manifested as inflammatory bowel disease-like symptoms and protein-losing gastroenteropathy
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Knowledge and awareness of early gastrointestinal cancer screening in Sunan Yugur Autonomous County in Gansu, China J. Int. Med. Res. (IF 1.6) Pub Date : 2024-03-14 Caihong Wang, Yumei Niu
ObjectiveWe aimed to assess the level of knowledge and awareness regarding the need for screening of early gastrointestinal cancer among residents of Sunan Yugur Autonomous County in China.MethodsIn this cross-sectional study, we conducted a survey among permanent residents of Sunan Yugur Autonomous County from January 2020 to January 2023 using a questionnaire to obtain data on knowledge regarding
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Bilateral plasma cell mastitis simulating breast cancer: a case report and literature review J. Int. Med. Res. (IF 1.6) Pub Date : 2024-03-14 John Ashindoitiang, Victor Nwagbara, Theophilus Ugbem, Joseph Ukam, Maurice Asuquo
Plasma cell mastitis (PCM) is a chronic inflammatory disease of the breast. It is a benign entity mainly found in nonpregnant and nonlactating women. PCM presents with symptoms of inflammation, breast erythema, masses, and indurations. We herein describe a 26-year-old woman with a 2-year history of right breast swelling and a 1-year history of left breast swelling during pregnancy and lactation. She
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Gastric metastasis from breast cancer: five cases and a single-institutional review J. Int. Med. Res. (IF 1.6) Pub Date : 2024-03-14 Meng Cheng, Zhanli Jia, Guoyu Zhang, Yingnan Wang, Sainan Li, Shan Yang, Chunxiao Li, Cuizhi Geng
Gastric metastasis from breast cancer has a high rate of misdiagnosis and missed diagnosis. Data of patients who had gastric metastasis from breast cancer were retrieved from our hospital between 2014 and 2020. The gastric metastasis from breast cancer incidence was 0.04% (5/14,169 cases of breast cancer). Four patients had invasive lobular carcinoma, and the other patient had invasive ductal carcinoma
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Dynamic lymphocyte-CRP ratio as a predictor: a single-centre retrospective study on disease severity and progression in adult COVID-19 patients J. Int. Med. Res. (IF 1.6) Pub Date : 2024-03-14 Dan Wang, Yang Gao, Qi-Qi Lai, Di Wu, Hui-Ying Liu, Huan Meng, Xin-Tong Wang, Yu-Jia Tang, Jia-Xi Xu, Jia-Ning Zhang, Bo-Wen Liu, Jian-Nan Zhang, Dong-Sheng Fei, Kai Kang
ObjectiveTo assess the efficacy of dynamic changes in lymphocyte-C-reactive protein ratio (LCR) on differentiating disease severity and predicting disease progression in adult patients with Coronavirus disease 2019 (COVID-19).MethodsThis single-centre retrospective study enrolled adult COVID-19 patients categorized into moderate, severe and critical groups according to the Diagnosis and Treatment of
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Porphyromonas gingivalis-induced hematogenous disseminated severe pneumonia: a case report J. Int. Med. Res. (IF 1.6) Pub Date : 2024-03-14 Zhou Yuanjun, Cai Yan, Zhang Qingyan, Xiong Feng
Porphyromonas gingivalis, a gram-negative oral anaerobe among more than more than 500 bacterial species that colonizing the oral cavity, is involved in the pathogenesis and prototypic polybacterial consortium of periodontitis. It is mainly found in oral infections and rarely present in other organ diseases. Here, we describe a 43-year-old man with underlying diabetes who developed hematogenous disseminated
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Importance of Capgras syndrome in shared psychotic disorder: a case report J. Int. Med. Res. (IF 1.6) Pub Date : 2024-03-13 Vladimir Knezevic, Dragana Ratkovic, Svetlana Ivanovic Kovacevic, Valentina Sobot, Ana Marija Vejnovic, Masa Comic
Shared psychotic disorder characterized by Capgras syndrome is an extremely rare condition. To our knowledge, there are only a few published papers on this condition. This paper presents a case of shared Capgras syndrome in two sisters. The inducer was a younger sister with schizophrenia, who passed on her Capgras delusion to her older sister after the death of their father. After committing a violent
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Risankizumab, a therapeutic alternative for psoriasis in people living with HIV J. Int. Med. Res. (IF 1.6) Pub Date : 2024-03-12 Tomás Estevinho, Egídio Freitas, Tiago Torres
The management of psoriasis in individuals with human immunodeficiency virus (HIV) presents a unique challenge, marked by a more severe progression and limited efficacy of first- and second-line treatments. Although conventional systemic therapies might be considered, these agents are immunosuppressants, making their use challenging in people living with HIV (PLHIV). Biologic agents are frequently
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Finite element analysis of different pedicle screw internal fixations for first lumbar vertebral fracture in different sports conditions J. Int. Med. Res. (IF 1.6) Pub Date : 2024-03-12 Pengpeng Ma, Zhenyu Li, Jun Miao, Xin Zhang, Zhiguo Zong, Tian Li
ObjectiveLumbar fractures are the most common spinal injuries, and surgery is required for severe fracture. This study aimed to investigate the variations in motion and stress in varying states of activity after minimally invasive and traditional open pedicle screw placement for L1 vertebral fracture stabilization.MethodsWe studied a male volunteer (26 years old) with no history of chronic back pain
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Delayed macular hole secondary to Terson syndrome: a case report and literature review J. Int. Med. Res. (IF 1.6) Pub Date : 2024-03-10 Yi Zhang, Chunyan Lei, Xi Huang, Meixia Zhang
Terson syndrome refers to intraocular haemorrhage that occurs due to subarachnoid bleeding associated with an acute increase in intracranial pressure. No previous study has reported a delayed macular hole (MH) secondary to Terson syndrome. A 17-year-old boy visited our department and presented with vitreous bleeding and a history of subarachnoid haemorrhage. Sub-internal limiting membrane (ILM) haemorrhage
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The role of registries in improving health and bridging healthcare, research, education, innovation and development: a research department perspective J. Int. Med. Res. (IF 1.6) Pub Date : 2024-03-10 Maria Lourdes Posadas-Martinez, Jimena Vicens, Adriana Ruth Dawidowski, Marcela Alejandra Martinez Von Scheidt, Vanina Laura Pagotto, Gabriela Alejandra Blugerman, Monica Gabriela Schpilberg, Adrian Carlos Gadano
Health registries are organized systems that collect data on individuals with a particular disease, condition or exposure. The aim of this narrative review was to provide an integrated perspective from the Research Department at the Hospital Italiano de Buenos Aires, Argentina, on how health registries can be used as a bridge between healthcare, research, education, innovation and development while
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Efficacy of laparoscopic pyeloplasty for pediatric hydronephrosis caused by symptomatic versus asymptomatic endogenous ureteropelvic junction obstruction: a retrospective analysis J. Int. Med. Res. (IF 1.6) Pub Date : 2024-03-10 Guanghui Shao, Zhihao Sun, Zhihang Zhou, Weizhen Wang, Aiwu Li
ObjectiveTo retrospectively compare the differences in the surgical efficacy and prognosis of laparoscopic pyeloplasty for hydronephrosis caused by symptomatic versus asymptomatic ureteropelvic junction obstruction (UPJO) in children and determine whether clinical symptoms affect the surgical outcome and prognosis.MethodsChildren who underwent laparoscopic pyeloplasty in our hospital from January 2018
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Predictors of congenital anomalies among neonates admitted to public hospitals in eastern Ethiopia: a case–control study J. Int. Med. Res. (IF 1.6) Pub Date : 2024-03-09 Nano Belama, Assefa Desalew, Magarsa Lami, Mulualem Keneni, Kedir Teji Roba
ObjectiveOver 8 million newborns worldwide have congenital anomalies; 3.2 million have resultant disabilities. Ethiopia has a high burden of neonatal congenital anomalies, but research on predictors is limited. This study investigated predictors of neonatal congenital anomalies in eastern Ethiopia.MethodsA facility-based unmatched case–control study on 387 mother–infant pairs (129 cases, 258 controls)
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Hepatitis B virus and cytomegalovirus coinfection in an older patient: a case report J. Int. Med. Res. (IF 1.6) Pub Date : 2024-03-08 Huimin Liu, Jiaqi Wang, Wenting Chen, Li Jiang, Qing Mao
Cytomegalovirus (CMV) infection involving the skin is relatively rare. We herein report a case involving a man in his late 70s with positive hepatitis B surface antigen who presented with multiform skin lesions, including a papuloid rash, papular urticaria, and purpura. The patient had taken no antiviral drugs for nearly 13 years but had recently developed severe liver injury. Laboratory examination
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Correlation between genetic alterations and clinicopathological features of papillary thyroid carcinomas J. Int. Med. Res. (IF 1.6) Pub Date : 2024-03-08 Shixuan Shang, Huimin Yang, Meixiang Chen, Jin Wu, Xianjun Shi, Xiangqin Li, Ningning Feng, Zhaoqing Zheng, Hongmei Liu, Yunzhi Zhang
ObjectiveTo investigate the correlations between multigene alterations and clinicopathological features in papillary thyroid carcinoma (PTC) samples.MethodsIn this retrospective study, 111 cytological specimens of thyroid nodules, including 74 PTC samples and 37 benign samples, were analyzed using a 22-gene mutation assay employing next-generation sequencing. Clinicopathological information was retrospectively
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Effects of prolonged face mask use among patients with hypertension or diabetes during the COVID-19 pandemic J. Int. Med. Res. (IF 1.6) Pub Date : 2024-03-08 Weiwei He, Yang Liu, Zhaoting Zou, Chunbao Cheng, Wenjing Wang, Zhixin Huang, Guannan Wu, Weiquan Zhu, Huiming Sun
ObjectiveWe aimed to investigate the impacts of prolonged mask use on patients with hypertension or diabetes during the COVID-19 pandemic.MethodsThis study included patients with hypertension or diabetes who visited the outpatient department of Nanjing Yimin Hospital between 1 February 2022 and 31 January 2023. We compared the change in blood pressure (BP) and fasting plasma glucose in patients with
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Screening of genes characteristic of pancreatic cancer by LASSO regression combined with support vector machine and recursive feature elimination, and immune correlation analysis J. Int. Med. Res. (IF 1.6) Pub Date : 2024-03-08 Longhui Zeng, Zheng Chen
BackgroundPancreatic cancer is a malignant tumor of the digestive tract that shows increased mortality, recurrence, and morbidity year on year.MethodsDifferentially expressed genes between pancreatic cancer and healthy tissues were first analyzed from four datasets within the Gene Expression Omnibus (GEO). Gene ontology, disease ontology, and gene set enrichment analysis of differentially expressed
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Effects of adipose-derived cell supplementation on tendon-bone healing in a rat model of chronic rotator cuff tear with suprascapular nerve injury J. Int. Med. Res. (IF 1.6) Pub Date : 2024-03-08 Kenichiro Eshima, Hiroki Ohzono, Masafumi Gotoh, Ryunosuke Abe, Hidehiro Nakamura, Yasuhiro Mitsui, Koji Hiraoka, Takahiro Okawa
ObjectiveTo investigate the effect of adipose-derived cells (ADCs) on tendon-bone healing in a rat model of chronic rotator cuff tear (RCT) with suprascapular nerve (SN) injury.MethodsAdult rats underwent right shoulder surgery whereby the supraspinatus was detached, and SN injury was induced. ADCs were cultured from the animals’ abdominal fat. At 6 weeks post-surgery, the animals underwent surgical
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Asymptomatic bacteriuria in patients with type 2 diabetes mellitus in rural southwestern Nigeria: a cross-sectional study J. Int. Med. Res. (IF 1.6) Pub Date : 2024-03-07 Azeez Oyemomi Ibrahim, Ibrahim Sebutu Bello, Oluwaserimi Adewumi Ajetunmobi, Kolawole Michael Olusuyi, Gbadebo Oladimeji Ajani, Kayode Rasaq Adewoye, Oluwatosin Oluwagbenga Oguntoye, Omowonuola Olubukola Sonibare, Ayodele Kamal Alabi
ObjectivesWe aimed to identify the prevalence, bacterial isolates, antimicrobial susceptibility profile, and factors associated with asymptomatic bacteriuria (ASB) in patients with type 2 diabetes mellitus (T2DM) in rural southwestern Nigeria.MethodsWe performed a hospital-based cross-sectional study of patients with T2DM and ASB. Demographic and clinical data were collected using questionnaires. Urine
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Correlates of early breastfeeding cessation and breastmilk expression in Uganda: a case–control study J. Int. Med. Res. (IF 1.6) Pub Date : 2024-03-06 Yu Du, Carolyn Onyango-Makumbi, Bhavneet Walia, Maxie Owor, Phillipa Musoke, Arthur H. Owora
ObjectiveTo identify the correlates of early breastfeeding (BF) cessation and breastmilk expression (BE) among mothers 12 months after childbirth.MethodsWe used a case-control study design to compare characteristics between mothers who stopped BF and expressed breastmilk 12 months after childbirth in Uganda. BF practices were determined in 12-month follow-up interviews using an adapted World Health
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The potential mechanism of ursolic acid in the treatment of bladder cancer based on network pharmacology and molecular docking J. Int. Med. Res. (IF 1.6) Pub Date : 2024-03-06 Xiao-Long Huang, Yan Sun, Peng Wen, Jun-Cheng Pan, Wei-Yang He
ObjectiveThis study explored the potential molecular mechanisms of ursolic acid (UA) in bladder cancer treatment using network pharmacology and molecular docking.MethodsThe Traditional Chinese Medicine Systems Pharmacology and UniProt databases were used to screen potential targets of UA. Relevant bladder cancer target genes were extracted using the GeneCards database. All data were pooled and intercrossed
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Respiratory failure as first presentation of myasthenia gravis: a case report J. Int. Med. Res. (IF 1.6) Pub Date : 2024-03-05 Fangming Wang, Jinming Cheng, Xiaoli Niu, Litao Li
Myasthenia gravis (MG) is often complicated by respiratory failure, an exacerbation known as myasthenic crisis. However, most patients with MG develop respiratory symptoms during the late course of the disease. Respiratory failure as an exclusive initial and primary complaint in patients with MG is rare and seldom reported. We herein describe a woman in her late 50s who presented with respiratory failure
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Biomarker cystatin B expression correlates with pathogenesis in cervical cancer J. Int. Med. Res. (IF 1.6) Pub Date : 2024-03-04 Danjuan Ye, Xiaoling Duan, Bin Guan, Jia Yuan, Yan Zhu, Jimin Shi, Qi Lu, Guoxiong Xu
ObjectiveCervical cancer (CC) is one of the most common gynecologic malignancies worldwide. Although rapid improvements have been made regarding its prevention and treatment, little is known about disease pathogenesis and the clinical relevance of reliable biomarkers. The present study evaluated the expression of cystatin B (CSTB) as a potential biomarker of CC.MethodsTissue microarray analysis and
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Neuronal intranuclear inclusion disease misdiagnosed as Parkinson’s disease: a case report J. Int. Med. Res. (IF 1.6) Pub Date : 2024-03-04 Dandan Yu, Jing Li, Hongfei Tai, Jing Ma, Zaiqiang Zhang, Wei Tang
Neuronal intranuclear inclusion disease (NIID) is a rare progressive neurodegenerative disease that mainly manifests as dementia, muscle weakness, sensory disturbances, and autonomic nervous dysfunction. Herein, we report a 68-year-old Chinese woman who was hospitalized because of resting tremor and bradykinesia that had been present for 7 years. Five years prior, bradykinesia and hypermyotonia had
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Distribution and appearance of myosin, dystrophin, and collagen IV in strabismus-affected extraocular muscle tissue compared with control tissue J. Int. Med. Res. (IF 1.6) Pub Date : 2024-03-04 Anna Junga, Tetyana Babenko, Pavlo Fedirko, Mara Pilmane
ObjectiveExtraocular muscles have complex development processes. The present study aimed to analyze the presence of myosin, dystrophin, and collagen IV in the strabismus-affected extraocular muscle.MethodsThis research was an observational case–control study. Myosin, dystrophin, and collagen IV were detected by histological and immunohistochemical analyses of extraocular muscle samples from concomitant
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Central serous chorioretinopathy associated with nonspecific orbital inflammation: a case report J. Int. Med. Res. (IF 1.6) Pub Date : 2024-03-04 Mahdi Sharifzadeh Kermani, Maryam Farsi, Ali Sharifi, Mahsa Sardarinia, Amin Zand
We herein present a rare case of acute central serous chorioretinopathy (CSC) associated with nonspecific orbital inflammation (NSOI). A 38-year-old woman presented with a 3-day history of ocular pain, reduced vision, periorbital swelling, proptosis, conjunctival chemosis, and restricted eye movements. Optical coherence tomography of the affected eye confirmed signs of CSC. Additionally, a computed
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Periprosthetic hip infections caused by Brucella: a rare case report and literature review J. Int. Med. Res. (IF 1.6) Pub Date : 2024-02-29 Jun Wei Feng, Peng Hao, Jiang Hu, Xia Deng, Yue Wang
Periprosthetic hip infection caused by Brucella abortus is rare and only a few cases have been reported. This current case report presents a case of a man in his early 50s who developed periprosthetic hip infection 2 years after right hip arthroplasty. There was no fever or pain, the usual cardinal signs of infection, except for a sinus tract at the previous surgical incision. Laboratory and arthrocentesis
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Penile traumatic testicular dislocation: a case report J. Int. Med. Res. (IF 1.6) Pub Date : 2024-02-29 Ze-Pai Chi, Yong-Hai Zhang
Traumatic testicular dislocation is rare and usually occurs in patients after a traumatic motor accident. Manual reduction or surgical exploration is the main treatment for this condition. We report a rare case of unilateral traumatic testicular dislocation in a man with an ectopic testis in the middle of the penis after a motorcycle crash injury. On the sixth day of hospitalization, the patient found
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A nomogram to predict the risk of surgery-related pressure ulcers in patients undergoing cardiovascular surgery J. Int. Med. Res. (IF 1.6) Pub Date : 2024-02-29 Xin Wei, Xiaoqing Xu, Yuan Chen
ObjectiveIn this study, we aimed to establish a new nomogram score to predict the occurrence of surgery-related pressure ulcers (SRPU) in patients undergoing cardiovascular surgery.MethodsWe conducted a retrospective study among patients who underwent cardiovascular surgery between February 2016 and November 2020.ResultsWe established a prediction model based on a logistic regression model and tested
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Epoxidase inhibitor-aspirin resistance and the relationship with genetic polymorphisms: a review J. Int. Med. Res. (IF 1.6) Pub Date : 2024-02-29 Xiaolin Hou
Strokes are the leading cause of death in most regions of the world. Epoxidase inhibitors include the drug aspirin (acetylsalicylic acid). Aspirin is widely used as first-line treatment for the prevention of cardiovascular and cerebrovascular diseases in at-risk patients. However, patients using conventional doses of aspirin can still develop ischaemic cardiovascular and cerebrovascular diseases, a
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Philadelphia chromosome-positive T-cell acute lymphoblastic leukemia: a case report J. Int. Med. Res. (IF 1.6) Pub Date : 2024-02-29 Qianze Dong, Tarneem Darwish, Meyerson Howard, Shashirekha Shetty, Yang Wang, Yan Xiu, Molly Gallogly, Chen Zhao
Philadelphia chromosome-positive (Ph+) T-cell acute lymphoblastic leukemia (T-ALL) is a rare and aggressive type of acute leukemia. The Philadelphia chromosome is the hallmark of chronic myeloid leukemia (CML). The differentiation between Ph+ T-ALL and T-cell lymphoblastic crisis of CML may be problematic in some cases. Here, we report a rare case of de novo Ph+ T-ALL that presented a diagnostic challenge
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Immature ovarian teratoma in a 20-year-old woman: A case report J. Int. Med. Res. (IF 1.6) Pub Date : 2024-02-27 L. Errami, A. Douzi, O. Lamzouri, H. Taheri, H. Saadi, A. Mimouni
Immature ovarian teratomas are a rare subtype of germ cell tumours characterized by the presence of embryonic elements, particularly primitive neuroepithelium, and they typically affect young women. We report the case of a 20-year-old woman who presented with a growing abdominal mass that turned out to be a grade II immature teratoma after adnexectomy. This article reviews the clinical presentation
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Severe lophomoniasis in a patient with diabetes and past history of COVID-19 in Central Iran: case report J. Int. Med. Res. (IF 1.6) Pub Date : 2024-02-27 Seyed Reza Mirbadie, Amirmasoud Taheri, Elahe Roshanzamir, Eissa Soleymani, Mahdi Fakhar
In this case report, we address the diagnostic challenges and clinical implications of severe infection with Lophomonas blattarum in a patient initially suspected of experiencing long COVID symptoms. We describe the patient's medical history, initial symptoms, diagnostic tests, and treatment. A female patient with diabetes in her early 60s presented with severe shortness of breath and was initially
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Plausible prediction of renoprotective effects of sodium-glucose cotransporter-2 inhibitors in patients with chronic kidney diseases J. Int. Med. Res. (IF 1.6) Pub Date : 2024-02-08 Alexander E Berezin, Tetiana A Berezina
This narrative review was conducted due to uncertainty in predicting the beneficial impact of sodium-glucose cotransporter-2 (SGLT2) inhibitors on a dip of estimated glomerular filtration rate (eGFR), regardless of albuminuria presence, with the aim of elucidating plausible predictors of kidney function outcome among patients treated with SGLT2 inhibitors. The PubMed and Web of Science databases were
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Age and lymphocyte/monocyte ratio as prognostic factors for autologous transplantation in the treatment of patients with follicular lymphoma J. Int. Med. Res. (IF 1.6) Pub Date : 2024-02-07 Anna Kenyeres, Evelin Kiss, Zsófia Simon, Árpád Illés, Ádám Jóna
ObjectiveFollicular lymphoma (FL) is an indolent, lymphoproliferative disease of B-cell origin that has a heterogeneous disease course with varying outcomes. Certain patients may undergo autologous stem cell transplantation. We investigated the outcome of autologous stem cell transplantation in patients with FL.MethodsPatients who received autologous stem cell transplantation at the University of Debrecen’s
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Evaluation of an artificial intelligence U-net algorithm for pulmonary nodule tracking on chest computed tomography images J. Int. Med. Res. (IF 1.6) Pub Date : 2024-02-07 Yuhei Takeshita, Shiro Onozawa, Shichiro Katase, Yuya Shirakawa, Kouji Yamashita, Jun Shudo, Akihito Nakanishi, Sadato Akahori, Kenichi Yokoyama
ObjectivesTo apply image registration in the follow up of lung nodules and verify the feasibility of automatic tracking of lung nodules using an artificial intelligence (AI) method.MethodsFor this retrospective, observational study, patients with pulmonary nodules 5–30 mm in diameter on computed tomography (CT) and who had at least six months follow-up were identified. Two radiologists defined a ‘correct’
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Postoperative care of 14 patients with left ventricular assist devices: a case series J. Int. Med. Res. (IF 1.6) Pub Date : 2024-02-06 Shenmin Wan, Yihong Chen, Xia Yuan, Ying Lin
A left ventricular assist device is a mechanical device that is surgically implanted in the heart to partially or completely replace the function of the heart. Left ventricular assist devices are of vital importance in the treatment of patients with heart failure. There are different recommendations for the postoperative care of patients undergoing left ventricular assist device implantation in different
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Echocardiographic quantification of mitral apparatus morphology and dynamics in patients with dilated cardiomyopathy J. Int. Med. Res. (IF 1.6) Pub Date : 2024-02-06 Despina-Manuela Toader
Mitral regurgitation is among the most common valvular heart diseases. Mitral regurgitation in patients with dilated cardiomyopathy is a complex pathology involving annular dilatation, papillary muscle displacement, systolic leaflet tethering, and left ventricular remodeling. Quantification of mitral apparatus damage in these patients is essential for successful interventional and surgical therapy
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Pan-cancer analysis revealing the multidimensional expression and prognostic and immunologic roles of TGFB1 in cancer J. Int. Med. Res. (IF 1.6) Pub Date : 2024-01-24 Zhitao Chen, Chenchen Ding, Jun Chen, Shusen Zheng, Qiyong Li
ObjectiveThis study aimed to perform an integrated pan-cancer analysis to characterize the expression patterns, prognostic value, genetic alterations, and immunologic roles of transforming growth factor beta 1 (TGFB1) across diverse human cancer types.MethodsBioinformatics analyses were conducted using multiple public databases including The Cancer Genome Atlas, Genotype-Tissue Expression, Clinical
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Therapeutic changes of systemic lupus erythematosus (SLE) patients in pregnancy and feto-maternal outcomes: a retrospective cohort study J. Int. Med. Res. (IF 1.6) Pub Date : 2024-01-24 Naser Al-Husban, Diala Walid Abu-Hassan, Ro’ya Ali Abu Saleem, Lara Al-Abdallat, Alhareth Eid Alhusban, Marwan H Adwan
ObjectivesPatients with systemic lupus erythematosus (SLE) frequently show non-compliance with their medication. We evaluated the compliance of patients with SLE in Jordan with their medication and the relationships with fetal and maternal outcomes.MethodsWe performed a retrospective cohort study of patients with SLE who had no co-morbidities or antiphospholipid syndrome; and were taking only prednisolone
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BRCA mutation status and pathological characterization of breast cancer in Zhoushan Islands, China J. Int. Med. Res. (IF 1.6) Pub Date : 2024-01-24 Shuhui Bao, Nini Sun, Yaling Li, Jiaojie Shu, Jing Xu, Yong Zhang, Xia Qiu
ObjectiveTo investigate BRCA1/ 2 gene mutations and their relationship with clinicopathological features in patients with breast cancer in Zhoushan Islands.MethodsHigh-throughput whole-exome gene sequencing was used to detect BRCA1/ 2 mutations in 776 breast cancer patients in Zhoushan Islands.ResultsThe BRCA1/ 2 mutation rate of breast cancer patients in Zhoushan Islands was 4.38% (34/776). BRCA1
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Reduction mammoplasty and mastopexy for multiple bilateral fibroadenomas: a case report and literature review J. Int. Med. Res. (IF 1.6) Pub Date : 2024-01-23 Lu Zhao, Lei Yang, Qian Yin
Treatment of multiple benign breast nodules is sometimes challenging with respect to establishing a surgical plan that achieves both therapeutic and cosmetic goals. Successful application of oncoplastic techniques has been reported in selected cases of benign breast lesions. In this case report, we present the surgical treatment and outcome of a patient with multiple fibroadenomas in ptotic and voluminous
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Clinical outcomes and predictors of bleomycin polidocanol foam sclerotherapy treatment response in venous malformations J. Int. Med. Res. (IF 1.6) Pub Date : 2024-01-23 Bin Ni, Jing-wen Liu, Xue-qiang Fan, Bin He, Qiang-qiang Nie, Zhi-dong Ye, Peng Liu, Jian-yan Wen
ObjectiveTo evaluate the safety and efficacy of bleomycin polidocanol foam (BPF) sclerotherapy for venous malformations (VMs) and analyze the associated clinical outcomes and predictors.MethodsWe retrospectively assessed BPF sclerotherapy outcomes in 138 patients with VMs. We analyzed pain levels, lesion volume reduction, and subjective perception of response. Logistic regression analysis was performed
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Osseointegration and osteoimmunology in implantology: assessment of the immune sustainability of dental implants using advanced sonographic diagnostics: research and case reports J. Int. Med. Res. (IF 1.6) Pub Date : 2024-01-23 Johann Lechner, Volker von Baehr, Florian Notter, Fabian Schick
ObjectiveBone marrow defects of the jaw (BMDJ) surrounding dental implants, in combination with impaired bone-to-implant contact (BIC), are difficult to detect in X-rays. This study evaluated BMDJ surrounding titanium (Ti-Impl) and ceramic (Cer-Impl) dental implants and incomplete BIC using a new trans-alveolar ultrasonography device (TAU) with numerical scaling for BIC.MethodsThe titanium stimulation
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Risk factors for hospital readmission among patients with cirrhosis and ascites in China: a retrospective observational study J. Int. Med. Res. (IF 1.6) Pub Date : 2024-01-23 Na Li, Mei Xu, Shi-Ying Liu, Ming-Qin Yu, Chun-Feng Ruan
ObjectiveIn this investigation, we aimed to explore risk factors for 90-day hospital readmission among patients with cirrhosis and ascites in an Asian population.MethodsIn this retrospective study, we included consecutive patients diagnosed with cirrhosis and ascites hospitalized in Renji Hospital between 2018 and 2022 to elucidate risk factors for 90-day readmission. We conducted multivariate logistic
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Mental health impact on patients with COVID-19 in the community under a long period of full lockdown in Vietnam J. Int. Med. Res. (IF 1.6) Pub Date : 2024-01-23 Dinh Viet Hung, Pham Ngoc Thao, Huynh Ngoc Lang, Le Thi Thu, Pham The Tai, Pham Quoc Toan, Dao Van Nhat, Nguyen Xuan Tien, Le Duy Chi, Do Duc Thuan
ObjectiveWe aimed to investigate the impact on the mental health of patients with COVID-19 in a centralized isolation facility in the community who experienced a long period of full lockdown during the fourth wave of the COVID-19 pandemic in Vietnam.MethodsWe performed a retrospective cross-sectional study among 125 patients with COVID-19 in a centralized isolation facility in the community of Ho Chi
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Impact of tourniquet use on severity of snakebite envenoming in Chongqing, China: a single-center retrospective study J. Int. Med. Res. (IF 1.6) Pub Date : 2024-01-23 Qian Yang, Yunhan Gao, Weijie Fu, Shaying Ma
ObjectiveTo identify risk factors associated with snakebite severity and determine whether tourniquet use can affect the severity and outcome of snakebites.MethodsThe clinical data of patients who sustained limb snakebites from 1 March 2021 to 31 October 2022 were reviewed. The patients were divided into three groups according to snakebite severity: mild (517 cases), moderate (112 cases), and severe
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Comparison of modified tumescent and conventional laparoscopic transabdominal preperitoneal inguinal hernia repair: a retrospective clinical study J. Int. Med. Res. (IF 1.6) Pub Date : 2024-01-20 Yilong Hu, Zhengwei Zhang, Feng Wang, Xiewu Qiu
ObjectiveLaparoscopic transabdominal preperitoneal (TAPP) inguinal hernia repair poses certain challenges to less experienced surgeons. This study was performed to compare the clinical outcomes of modified tumescent laparoscopic TAPP (MT-TAPP) inguinal hernia repair versus conventional laparoscopic TAPP (CL-TAPP) inguinal hernia repair.MethodsWe retrospectively analyzed the perioperative data of patients
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Efficacy and safety of modified Valsalva maneuver for treatment of paroxysmal supraventricular tachycardia: a meta-analysis J. Int. Med. Res. (IF 1.6) Pub Date : 2024-01-18 Zhao Lu, Jieyun Zhu, Min Gao, Qiuyun Song, Dongzan Pan, Chunli Huang, Liangfeng Zhu, Yin Shen
ObjectiveTo compare the efficacy and safety of the modified versus standard Valsalva maneuver in the treatment of paroxysmal supraventricular tachycardia (PSVT).MethodsThe PubMed, Embase, Web of Science, CNKI, WanFang Data, and VIP electronic databases were searched to identify studies comparing the modified and standard Valsalva maneuvers in the treatment of PSVT from database inception to 1 May 2023
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Temporal inverted internal limiting membrane flap technique for myopic macular hole retinal detachment reconstruction J. Int. Med. Res. (IF 1.6) Pub Date : 2024-01-18 Yan Teng, Xiaoyu Zhang
ObjectiveTo examine the effects of the temporal inverted internal limiting membrane (ILM) flap technique for foveal reconstruction in patients with highly myopic macular hole-associated retinal detachment (MHRD).MethodsA retrospective case series analysis of four patients (four eyes) with MHRD was conducted. The foveal optical coherence tomography changes following treatment using the temporal inverted
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Applications of artificial intelligence in gastroscopy: a narrative review J. Int. Med. Res. (IF 1.6) Pub Date : 2024-01-18 Hu Chen, Shi-yu Liu, Si-hui Huang, Min Liu, Guang-xia Chen
Gastroscopy, a critical tool for the diagnosis of upper gastrointestinal diseases, has recently incorporated artificial intelligence (AI) technology to alleviate the challenges involved in endoscopic diagnosis of some lesions, thereby enhancing diagnostic accuracy. This narrative review covers the current status of research concerning various applications of AI technology to gastroscopy, then discusses
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Folic acid: friend or foe in cancer therapy J. Int. Med. Res. (IF 1.6) Pub Date : 2024-01-17 Romany H. Thabet, Raneem Eid Mustafa Alessa, Zahraa Khaldoon Khaleel Al-Smadi, Banah Saleh Gabr Alshatnawi, Batool Mahmoud Ibrahim Amayreh, Renad Bilal Ahmad Al-Dwaaghreh, Sereen Khalid Ahmad Salah
Folic acid plays a crucial role in diverse biological processes, notably cell maturation and proliferation. Here, we performed a literature review using articles listed in electronic databases, such as PubMed, Scopus, MEDLINE, and Google Scholar. In this review article, we describe contradictory data regarding the role of folic acid in cancer development and progression. While some studies have confirmed
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A multiplex recombinase polymerase amplification assay combined with CRISPR/Cas12a for the detection of respiratory syncytial virus and respiratory adenovirus J. Int. Med. Res. (IF 1.6) Pub Date : 2024-01-17 Gao Hongdan, Du Yao, Chai Qiang, Huang Meng, Liu Xiaorong, Xing Zhihao, Ma Dongli
ObjectiveRespiratory syncytial virus (RSV) and respiratory adenovirus (ADV) are two common pathogens that cause acute respiratory tract infections in children. We aimed to develop a rapid method for detecting both pathogens simultaneously.MethodsThe recombinase polymerase isothermal amplification (RPA) method was combined with the CRISPR/Cas detection system. The assay’s specificity and sensitivity
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Airway leakage due to malpositioning of esophageal temperature probe during robot-assisted radical prostatectomy: a case report J. Int. Med. Res. (IF 1.6) Pub Date : 2024-01-13 Jong Min Lee, Chang Mook Lim, Jae Hoon Jung, Seok Jin Lee, Hong Seuk Yang, Chang Yeong Jeong, Dong Ho Park
Measuring patients’ core body temperature during surgery is essential and commonly performed with an esophageal temperature probe. The probe must be placed in the lower third of the esophagus for accurate measurement. In this case report, we describe our experience of discovering an inadvertently malpositioned esophageal temperature probe in the right inferior lobar bronchus, which led to ventilation-related
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Neuropsychiatric manifestations of tuberous sclerosis in a young man in a psychiatric hospital in Botswana: a case report J. Int. Med. Res. (IF 1.6) Pub Date : 2024-01-13 Wame T. Chabalala, Kagiso Bojosi, Tseleng Maphane, Anthony A. Olashore
Tuberous sclerosis complex (TSC), first described in 1880, is a disorder that affects multiple systems. Its symptoms include seizures, intellectual disability, and angiofibromas. TSC is caused by mutations in the TSC1 and TSC2 genes and is inherited in an autosomal dominant manner. The present report describes the case of a patient with an unusual psychological presentation who was evaluated in a psychiatric
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Non-classical Bordetella sp. (closely related to Bordetella hinzii and Bordetella pseudohinzii) lower respiratory tract infection in a patient with extensive bronchiectasis: a case report J. Int. Med. Res. (IF 1.6) Pub Date : 2024-01-13 Shih Keng Loong, Chong Kin Liam, Rina Karunakaran, Kim-Kee Tan, Nur Hidayana Mahfodz, Sazaly AbuBakar
An increasing number of reports have described the pathogenic nature of several non-classical Bordetella spp. Among them, Bordetella hinzii and Bordetella pseudohinzii have been implicated in a myriad of respiratory-associated infections in humans and animals. We report the isolation of a genetically close relative of B. hinzii and B. pseudohinzii from the sputum of a woman in her early 60s with extensive
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Identification of L5 vertebra on lumbar spine radiographs using deep learning J. Int. Med. Res. (IF 1.6) Pub Date : 2024-01-11 Jeoung Kun Kim, Min Cheol Chang, Wook Tae Park, Gun Woo Lee
ObjectiveDeep learning is an advanced machine-learning approach that is used in several medical fields. Here, we developed a deep learning model using an object detection algorithm to identify the L5 vertebra on anteroposterior lumbar spine radiographs, and assessed its detection accuracy.MethodsWe retrospectively recruited 150 participants for whom both anteroposterior whole-spine and lumbar spine
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Atrioventricular block in patients with hyperthyroidism: a narrative review J. Int. Med. Res. (IF 1.6) Pub Date : 2024-01-11 Fateen Ata
Atrioventricular block (AVB) is a rare cardiac manifestation of hyperthyroidism (HTH). The scientific literature contains multiple reports of AVB in patients with HTH, ranging from subclinical to overt HTH and even thyroid storm. However, much remains unknown about the true prevalence, clinical course, optimal management, and outcomes of AVB in patients with HTH. Such patients are possibly overtreated
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Predictive factors of psoriatic arthritis in a diverse population with psoriasis J. Int. Med. Res. (IF 1.6) Pub Date : 2024-01-11 Wai Yang Loo, Ying Chew Tee, Winn Hui Han, Nik Aimee Azizah Faheem, Shin Shen Yong, Zhenli Kwan, Lydia Say Lee Pok, Fariz Yahya
ObjectiveWe aimed to analyze the clinical characteristics of patients with psoriasis and determine the predictive factors of psoriatic arthritis (PsA).MethodsThis retrospective cohort study was performed among patients with psoriasis. Demographic and clinical data were collected. Psoriasis treatment was categorized as topical agents, phototherapy, oral therapy, and biologics. Predictive factors of