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Chromosomal Microarray Analysis in Fetuses With Ultrasonographic Soft Markers: A Meta-Analysis of the Current Evidence. J. Korean Med. Sci. (IF 4.5) Pub Date : 2024-03-04 Uisuk Kim, Young Mi Jung, Sohee Oh, Ji Hye Bae, Jeesun Lee, Chan-Wook Park, Joong Shin Park, Jong Kwan Jun, Seung Mi Lee
Ultrasonographic soft markers are normal variants, rather than fetal abnormalities, and guidelines recommend a detailed survey of fetal anatomy to determine the necessity of antenatal karyotyping. Anecdotal reports have described cases with ultrasonographic soft markers in which chromosomal microarray analysis (CMA) revealed pathogenic copy number variants (CNVs) despite normal results on conventional
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Comparison of High- and Low-Dose Rivaroxaban Regimens in Elderly East Asian Patients With Atrial Fibrillation. J. Korean Med. Sci. (IF 4.5) Pub Date : 2024-03-04 Ju Youn Kim, Juwon Kim, Seung-Jung Park, Kyoung-Min Park, June Soo Kim, Sung-Hwan Kim, Jaemin Shim, Eue Keun Choi, Dae-Hyeok Kim, Il-Young Oh, Young Keun On
In the Rivaroxaban Once-daily oral direct factor Xa inhibition Compared with vitamin K antagonism for prevention of stroke and Embolism Trial in Atrial Fibrillation (ROCKET AF) trial, rivaroxaban 20 mg was the on-label dose, and the dose-reduction criterion for rivaroxaban was a creatinine clearance of < 50 mL/min. Some Asian countries are using reduced doses label according to the J-ROCKET AF trial
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Risk Factors for the Mortality of Patients With Coronavirus Disease 2019 Requiring Extracorporeal Membrane Oxygenation in a Non-Centralized Setting: A Nationwide Study. J. Korean Med. Sci. (IF 4.5) Pub Date : 2024-03-04 Tae Wan Kim, Won-Young Kim, Sunghoon Park, Su Hwan Lee, Onyu Park, Taehwa Kim, Hye Ju Yeo, Jin Ho Jang, Woo Hyun Cho, Jin-Won Huh, Sang-Min Lee, Chi Ryang Chung, Jongmin Lee, Jung Soo Kim, Sung Yoon Lim, Ae-Rin Baek, Jung-Wan Yoo, Ho Cheol Kim, Eun Young Choi, Chul Park, Tae-Ok Kim, Do Sik Moon, Song-I Lee, Jae Young Moon, Sun Jung Kwon, Gil Myeong Seong, Won Jai Jung, Moon Seong Baek
Limited data are available on the mortality rates of patients receiving extracorporeal membrane oxygenation (ECMO) support for coronavirus disease 2019 (COVID-19). We aimed to analyze the relationship between COVID-19 and clinical outcomes for patients receiving ECMO.
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Adverse Events Following COVID-19 Vaccination in Adolescents: Insights From Pharmacovigilance Study of VigiBase. J. Korean Med. Sci. (IF 4.5) Pub Date : 2024-03-04 Dong Hyuk Kim, Ju Hwan Kim, In-Sun Oh, Young June Choe, Seung-Ah Choe, Ju-Young Shin
During coronavirus disease 2019 (COVID-19) pandemic, several COVID-19 vaccines were licensed with fast-track procedures. Although these vaccines have demonstrated high immunogenicity, there has been concerns on the serious adverse events (AEs) following COVID-19 vaccination among adolescents. We aimed to analyze comparative safety of COVID-19 vaccination in adolescents.
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Association Between Multiple Heavy Metal Exposures and Cholesterol Levels in Residents Living Near a Smelter Plant in Korea. J. Korean Med. Sci. (IF 4.5) Pub Date : 2024-03-04 Sun-In Moon, Dong-Hyuk Yim, Kyunghi Choi, Sang-Yong Eom, Byung-Sun Choi, Jung-Duck Park, Heon Kim, Yong-Dae Kim
Considering the interactions between heavy metals, a comprehensive evaluation of the effects of exposure to various types of co-interacting heavy metals on health is required. This study assessed the association between dyslipidemia markers and blood mercury, lead, cadmium, iron, zinc, and nickel levels in residents of an abandoned refinery plant.
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Mildly Reduced Renal Function Is Associated With Increased Heart Failure Admissions in Patients With Hypertrophic Cardiomyopathy. J. Korean Med. Sci. (IF 4.5) Pub Date : 2024-03-04 Nan Young Bae, Tae-Min Rhee, Chan Soon Park, You-Jung Choi, Hyun-Jung Lee, Hong-Mi Choi, Jun-Bean Park, Yeonyee E Yoon, Yong-Jin Kim, Goo-Yeong Cho, In-Chang Hwang, Hyung-Kwan Kim
The association between renal dysfunction and cardiovascular outcomes has yet to be determined in patients with hypertrophic cardiomyopathy (HCM). We aimed to investigate whether mildly reduced renal function is associated with the prognosis in patients with HCM.
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Impact of Lactate Dehydrogenase and Hemoglobin Levels on Clinical Outcomes in Patients With Paroxysmal Nocturnal Hemoglobinuria: Results From the National Korean PNH Registry. J. Korean Med. Sci. (IF 4.5) Pub Date : 2024-03-04 Jun Ho Jang, Jin Seok Kim, Cindy Thiow Koon Lim, Nora J Kleinman, Karl-Johan Myren, Alice Wang, Yogesh Patel, Jong Wook Lee
Paroxysmal nocturnal hemoglobinuria (PNH) is a rare hematologic disorder caused by uncontrolled terminal complement activation, which leads to intravascular hemolysis (IVH), thromboembolism (TE), renal failure, and premature mortality.
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Adverse Reactions After Intradermal Vaccination With JYNNEOS for Mpox in Korea. J. Korean Med. Sci. (IF 4.5) Pub Date : 2024-03-04 So Yun Lim, Yu Mi Jung, Yeonjae Kim, Gayeon Kim, Jaehyun Jeon, BumSik Chin, Min-Kyung Kim
In response to the Mpox domestic epidemic, South Korea initiated a nationwide vaccination program in May 2023, administering a 0.1 mL intradermal dose of JYNNEOS (Modified Vaccinia Ankara vaccine, Bavarian Nordic) to a high-risk group. To investigate the adverse reactions after intradermal JYNNEOS vaccination, an anonymous online survey was conducted at the National Medical Center from May 22 to July
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YouTube as a Source of Information on Public Health Ethics. J. Korean Med. Sci. (IF 4.5) Pub Date : 2024-02-26 Alikhan Zhaksylyk, Marlen Yessirkepov, Ahmet Akyol, Burhan Fatih Kocyigit
Public health ethics (PHE) is a dynamic area within bioethics that addresses the complex moral implications of public health measures in the face of growing health threats. YouTube is a powerful and widely used platform for disseminating health-related information. The primary objective of this study is to assess videos related to PHE on YouTube. The aim is to gauge the extent of misinformation in
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Do Death Certificate Errors Decrease as Clinical Experience in an Emergency Department Increases? J. Korean Med. Sci. (IF 4.5) Pub Date : 2024-02-26 Jung Jun Kim, Sun Hyu Kim, Sangyup Chung, Byeong Ju Park, Soobeom Park, Song Yi Park
This study aimed to evaluate the relationship between clinical experience and death certificate (DC) errors by analyzing DCs written by experienced emergency physicians (EPs).
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Sextant Systematic Biopsy Versus Extended 12-Core Systematic Biopsy in Combined Biopsy for Prostate Cancer. J. Korean Med. Sci. (IF 4.5) Pub Date : 2024-02-26 Jae Hoon Chung, Wan Song, Minyong Kang, Hyun Hwan Sung, Hwang Gyun Jeon, Byong Chang Jeong, Seong Il Seo, Seong Soo Jeon, Hyun Moo Lee, Byung Kwan Park
This study assessed the comparative effectiveness of sextant and extended 12-core systematic biopsy within combined biopsy for the detection of prostate cancer.
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Current Status of Latent Tuberculosis Infection Treatment Among Pediatric Patients in Korea: Prescription and Treatment Completion. J. Korean Med. Sci. (IF 4.5) Pub Date : 2024-02-26 Yejin Kim, Kil Seong Bae, Ui Yoon Choi, Seung Beom Han, Jong-Hyun Kim
The treatment of pediatric patients with latent tuberculosis infection (LTBI) is a crucial TB control strategy. LTBI is not a reportable communicable disease, and data regarding LTBI treatment in pediatric patients in Korea are scarce. This study aimed to investigate the prescription patterns and treatment completion rates among pediatric patients with LTBI in Korea by analyzing National Health reimbursement
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Measuring the Burden of Disease in Korea Using Disability-Adjusted Life Years (2008-2020). J. Korean Med. Sci. (IF 4.5) Pub Date : 2024-02-26 Yoon-Sun Jung, Young-Eun Kim, Minsu Ock, Seok-Jun Yoon
The measurement of health levels and monitoring of characteristics and trends among populations and subgroups are essential for informing evidence-based policy decisions. This study aimed to examine the burden of disease in Korea for both the total population and subgroups in 2020, as well as analyze changes in disease burden from 2008 to 2020.
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Differences in Brain Metabolite Profiles Between Normothermia and Hypothermia. J. Korean Med. Sci. (IF 4.5) Pub Date : 2024-02-26 Suk Ho Sohn, Sihyun Chae, Jae Woong Choi, Karam Nam, Youn Joung Cho, Joo-Youn Cho, Ho Young Hwang
This study evaluated the difference in brain metabolite profiles between normothermia and hypothermia reaching 25°C in humans in vivo.
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Trends in Healthy Life Expectancy (HALE) and Disparities by Income and Region in Korea (2008-2020): Analysis of a Nationwide Claims Database. J. Korean Med. Sci. (IF 4.5) Pub Date : 2024-02-19 Yoon-Sun Jung, Young-Eun Kim, Minsu Ock, Seok-Jun Yoon
Healthy life expectancy is a well-recognized indicator for establishing health policy goals used in Korea's Health Plan. This study aimed to explore Koreans' healthy life expectancy and its gender, income, and regional disparities from 2008 to 2020.
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Increased Apolipoprotein B/Apolipoprotein A-I Ratio Is Associated With Decline in Lung Function in Healthy Individuals: The Kangbuk Samsung Health Study. J. Korean Med. Sci. (IF 4.5) Pub Date : 2024-02-19 Jonghoo Lee, Hye Kyeong Park, Min-Jung Kwon, Soo-Youn Ham, Hyun-Il Gil, Si-Young Lim, Jae-Uk Song
Lung dysfunction and high apolipoprotein B/apolipoprotein A-I (apoB/apoA-I) ratio are both recognized risk factors for cardiovascular disease. However, few studies have examined the association between the apoB/ApoA-I ratio and lung function. Therefore, we investigated whether this ratio is associated with decreased lung function in a large healthy cohort.
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Determining and Comparing the Real-World Effectiveness of Molnupiravir and Nirmatrelvir-Ritonavir in Patients Hospitalized With COVID-19. J. Korean Med. Sci. (IF 4.5) Pub Date : 2024-02-19 Young Rock Jang, Yoonju Oh, Jin Yong Kim
Current guidelines recommend using nirmatrelvir-ritonavir for coronavirus disease 2019 (COVID-19) treatment, but its potential drug interactions and contraindications limit its applicability in certain categories of patients. The aim of the study was to evaluate the real-world effectiveness of molnupiravir and nirmatrelvir-ritonavir in managing COVID-19 among hospitalized patients.
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Variation in the Allergenicity of Scrambled, Boiled, Short-Baked and Long-Baked Egg White Proteins. J. Korean Med. Sci. (IF 4.5) Pub Date : 2024-02-19 Purevsan Gantulga, Jeongmin Lee, Kyunguk Jeong, Se-Ah Jeon, Sooyoung Lee
Hen's egg white (HEW) is the most common cause of food allergy in children which induces mild to fatal reactions. The consultation for a proper restriction is important in HEW allergy. We aimed to identify the changes in HEW allergenicity using diverse cooking methods commonly used in Korean dishes.
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Pneumonia Prevalence Upon Chest Radiography According to Vaccination Status Among Patients Under 50 Years of Age With Coronavirus Disease 2019. J. Korean Med. Sci. (IF 4.5) Pub Date : 2024-02-19 Yong Shik Kwon, Sun Hyo Park, Hyun Jung Kim, Jae Seok Park, Mi-Ae Kim, Tae Hun Kim, Ji Yeon Lee, Jin Young Kim
Coronavirus disease 2019 (COVID-19) vaccination is effective in preventing the disease transmission and progression. However, the relatively mild disease course of the omicron variant and the decrease in antibodies over time after vaccination raise questions about the effectiveness of vaccination, especially in young people. We compared the prevalence of pneumonia and chest X-ray severity score according
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Effects of Transport to Trauma Centers on Survival Outcomes Among Severe Trauma Patients in Korea: Nationwide Age-Stratified Analysis. J. Korean Med. Sci. (IF 4.5) Pub Date : 2024-02-19 Hakrim Kim, Kyoung Jun Song, Ki Jeong Hong, Jeong Ho Park, Tae Han Kim, Stephen Gyung Won Lee
Previous studies showed that the prognosis for severe trauma patients is better after transport to trauma centers compared to non-trauma centers. However, the benefit from transport to trauma centers may differ according to age group. The aim of this study was to compare the effects of transport to trauma centers on survival outcomes in different age groups among severe trauma patients in Korea.
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The Impact of Withdrawing or Withholding of Life-Sustaining Treatment: A Nationwide Case-Control Study Based on Medical Cost Analysis. J. Korean Med. Sci. (IF 4.5) Pub Date : 2024-02-19 Claire Junga Kim, Do-Kyong Kim, Sookyeong Mun, Minkook Son
This study measured the impact of the Decisions on Life-Sustaining Treatment Act by analyzing medical cost data from the National Health Insurance Service-National Sample Cohort. After identifying the patients who died in 2018 and 2019, the case and control groups were set using the presence of codes for managing the implementation of life-sustaining treatment with propensity score matching. Regarding
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Erratum: Correction of Tables in the Article "Reference Respiratory Muscle Strength Values and a Prediction Equation Using Physical Functions for Pulmonary Rehabilitation in Korea". J. Korean Med. Sci. (IF 4.5) Pub Date : 2024-02-19 Tae Sung Park, Young Jin Tak, Youngjin Ra, Jinmi Kim, Sang Hun Han, Sang Hun Kim, YongBeom Shin, Myung-Jun Shin, Jong Ho Kang
This corrects the article on p. e325 in vol. 38, PMID: 37846788.
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Realistic Estimation of COVID-19 Infection by Seroprevalence Surveillance of SARS-CoV-2 Antibodies: An Experience From Korea Metropolitan Area From January to May 2022. J. Korean Med. Sci. (IF 4.5) Pub Date : 2024-02-05 In Hwa Jeong, Jong-Hun Kim, Min-Jung Kwon, Jayoung Kim, Hee Jin Huh, Byoungguk Kim, Junewoo Lee, Jeong-Hyun Nam, Eun-Suk Kang
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread globally, leading to the coronavirus disease 2019 (COVID-19) pandemic. Because a significant proportion of the COVID-19 confirmed cases were concentrated in the capital metropolitan area of South Korea, and a large proportion of the population in the area had been adequately vaccinated against COVID-19, we conducted a seroprevalence
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Establishment of Safety Monitoring System for Vaccines Not Included in the National Immunization Program in Korea. J. Korean Med. Sci. (IF 4.5) Pub Date : 2024-02-05 Eliel Nham, Jin Gu Yoon, Min Joo Choi, Yu Bin Seo, Jacob Lee, Won Suk Choi, Hakjun Hyun, Hye Seong, Ji Yun Noh, Joon Young Song, Woo Joo Kim, Hee Jin Cheong
In Korea, there are no surveillance programs for vaccines that are not included in the national immunization program (NIP), and vaccine safety monitoring in the adult population is inadequate. This study aimed to establish a safety monitoring system for non-NIP vaccines in adults.
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Validation of the Framingham Diabetes Risk Model Using Community-Based KoGES Data. J. Korean Med. Sci. (IF 4.5) Pub Date : 2024-02-05 Hye Ah Lee, Hyesook Park, Young Sun Hong
An 8-year prediction of the Framingham Diabetes Risk Model (FDRM) was proposed, but the predictor has a gap with current clinical standards. Therefore, we evaluated the validity of the original FDRM in Korean population data, developed a modified FDRM by redefining the predictors based on current knowledge, and evaluated the internal and external validity.
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Guillain-Barré Syndrome After COVID-19 Infection in Korea: A Case Series. J. Korean Med. Sci. (IF 4.5) Pub Date : 2024-02-05 Nayoung Ryoo, Hyoshin Son, Jean Hee Kim, Dae Woong Bae, Jae Young An
Guillain-Barré syndrome (GBS) is an autoimmune-driven condition characterized by acute polyneuropathy, often emerging as a sequel to prior infections or vaccinations. This study presents the first reported cases of GBS emerging after the full recovery from coronavirus disease 2019 (COVID-19) infection in Korea. Despite experiencing mild acute COVID-19 symptoms, these patients faced substantial weakness
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Consensus Statements on the Definition, Classification, and Diagnostic Tests for Tinnitus: A Delphi Study Conducted by the Korean Tinnitus Study Group. J. Korean Med. Sci. (IF 4.5) Pub Date : 2024-02-05 Oak-Sung Choo, Hantai Kim, Seung Jae Lee, So Young Kim, Kyu-Yup Lee, Ho Yun Lee, In Seok Moon, Jae-Hyun Seo, Yoon Chan Rah, Jae-Jun Song, Eui-Cheol Nam, Shi Nae Park, Jae-Jin Song, Hyun Joon Shim
Tinnitus is a bothersome condition associated with various symptoms. However, the mechanisms of tinnitus are still uncertain, and a standardized assessment of the diagnostic criteria for tinnitus is required. We aimed to reach a consensus on diagnosing tinnitus with professional experts by conducting a Delphi study with systematic review of the literature.
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The Risk of Hypertension and Diabetes Mellitus According to Offspring's Birthweight in Women With Normal Body Mass Index: A Nationwide Population-Based Study. J. Korean Med. Sci. (IF 4.5) Pub Date : 2024-02-05 Young Mi Jung, Wonyoung Wi, Kyu-Dong Cho, Su Jung Hong, Ho Yeon Kim, Ki Hoon Ahn, Soon-Cheol Hong, Hai-Joong Kim, Min-Jeong Oh, Geum Joon Cho
Maladaptation to vascular, metabolic, and physiological changes during pregnancy can lead to fetal growth disorders. Moreover, adverse outcomes during pregnancy can further increase the risk of cardiovascular and metabolic diseases in mothers. Delivering a large-for-gestational-age (LGA) baby may indicate a pre-existing metabolic dysfunction, whereas delivering a small-for-gestational-age (SGA) baby
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Early Prediction of Mortality for Septic Patients Visiting Emergency Room Based on Explainable Machine Learning: A Real-World Multicenter Study. J. Korean Med. Sci. (IF 4.5) Pub Date : 2024-02-05 Sang Won Park, Na Young Yeo, Seonguk Kang, Taejun Ha, Tae-Hoon Kim, DooHee Lee, Dowon Kim, Seheon Choi, Minkyu Kim, DongHoon Lee, DoHyeon Kim, Woo Jin Kim, Seung-Joon Lee, Yeon-Jeong Heo, Da Hye Moon, Seon-Sook Han, Yoon Kim, Hyun-Soo Choi, Dong Kyu Oh, Su Yeon Lee, MiHyeon Park, Chae-Man Lim, Jeongwon Heo
Worldwide, sepsis is the leading cause of death in hospitals. If mortality rates in patients with sepsis can be predicted early, medical resources can be allocated efficiently. We constructed machine learning (ML) models to predict the mortality of patients with sepsis in a hospital emergency department.
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Identification of Atrial Fibrillation With Single-Lead Mobile ECG During Normal Sinus Rhythm Using Deep Learning. J. Korean Med. Sci. (IF 4.5) Pub Date : 2024-02-05 Jiwoong Kim, Sun Jung Lee, Bonggyun Ko, Myungeun Lee, Young-Shin Lee, Ki Hong Lee
The acquisition of single-lead electrocardiogram (ECG) from mobile devices offers a more practical approach to arrhythmia detection. Using artificial intelligence for atrial fibrillation (AF) identification enhances screening efficiency. However, the potential of single-lead ECG for AF identification during normal sinus rhythm (NSR) remains under-explored. This study introduces a method to identify
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Clinical Features of Mpox Patients in Korea: A Multicenter Retrospective Study. J. Korean Med. Sci. (IF 4.5) Pub Date : 2024-01-29 So Yun Lim, Hyeon Jae Jo, Su-Yeon Lee, Miyoung Ahn, Yeonjae Kim, Jaehyun Jeon, Eu Suk Kim, BumSik Chin, Jae-Phil Choi, Nam Joong Kim
Mpox is a viral illness with a characteristic skin rash caused by the monkeypox virus. In 2022, Mpox spread throughout the world, and an epidemic through domestic transmission started in South Korea in early 2023. This study aimed to summarize the clinical features of Mpox patients in South Korea.
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Spirometric Interpretation and Clinical Relevance According to Different Reference Equations. J. Korean Med. Sci. (IF 4.5) Pub Date : 2024-01-29 Hyun Woo Lee, Jung-Kyu Lee, Yong-Il Hwang, Hyewon Seo, June Hong Ahn, Sung-Ryeol Kim, Hyun Jung Kim, Ki-Suck Jung, Kwang Ha Yoo, Deog Kyeom Kim
Global Lung Function Initiative (GLI)-2012 reference equation is currently suggested for interpretation of spirometry results and a new local reference equation has been developed in South Korea. However, lung function profiles according to the different reference equations and their clinical relevance have not been identified in chronic obstructive pulmonary disease (COPD) patients.
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Risk of Pancreatic Cancer After Acute Pancreatitis: A Retrospective Analysis of the Korean National Sample Cohort. J. Korean Med. Sci. (IF 4.5) Pub Date : 2024-01-29 Sung Hoon Jeong, Kyungduk Hurh, Eun-Cheol Park, Ja-Ho Leigh, Seung Hoon Kim, Sung-In Jang
Acute pancreatitis may increase the risk of pancreatic cancer, although this association remains unclear. Therefore, we aimed to investigate this association.
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The Epidemiology of Hepatitis B Virus Infection in Korea: 15-Year Analysis. J. Korean Med. Sci. (IF 4.5) Pub Date : 2024-01-29 Log Young Kim, Jeong-Ju Yoo, Young Chang, Hoongil Jo, Young Youn Cho, Sangheun Lee, Dong Hyeon Lee, Jae Young Jang
The purpose of this study is to investigate the epidemiological changes in chronic hepatitis B (CHB) and assess the impact of coronavirus disease 2019 (COVID-19) over the past 15 years in a region endemic to hepatitis B virus (HBV).
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Factors Affecting Adherence to National Colorectal Cancer Screening: A 12-Year Longitudinal Study Using Multi-Institutional Pooled Data in Korea. J. Korean Med. Sci. (IF 4.5) Pub Date : 2024-01-29 Dae Sung Kim, Jeeyoung Hong, Kihyun Ryu, Sang Hyuk Lee, Hwanhyi Cho, Jehyeong Yu, Jieun Lee, Jong-Yeup Kim
Consistent uptake of colorectal cancer (CRC) screening is important to reduce the incidence and mortality from advanced-stage CRC and increase the survival rate of the patients. We conducted a longitudinal study to determine the factors affecting CRC screening compliance in Korean adults using individual-level linked data from the Korean National Health and Nutrition Examination Survey, Korean National
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The Risk of COVID-19 and Its Outcomes in Korean Patients With Gout: A Multicenter, Retrospective, Observational Study. J. Korean Med. Sci. (IF 4.5) Pub Date : 2024-01-29 Min Jung Kim, Borim Ryu, Eun-Gee Park, Siyeon Yi, Kwangsoo Kim, Jun Won Park, Kichul Shin
This retrospective cohort study aimed to compare coronavirus disease 2019 (COVID-19)-related clinical outcomes between patients with and without gout. Electronic health record-based data from two centers (Seoul National University Hospital [SNUH] and Boramae Medical Center [BMC]), from January 2021 to April 2022, were mapped to a common data model. Patients with and without gout were matched using
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Prevalence and Burden of Human Adenovirus-Associated Acute Respiratory Illness in the Republic of Korea Military, 2013 to 2022. J. Korean Med. Sci. (IF 4.5) Pub Date : 2024-01-29 Donghoon Kim, Eunyoung Lee, Jungmin Eom, Yeonjae Kim, Soon-Hwan Kwon, Hong Sang Oh, Kyungmin Huh, Hyesook Park, Jaehun Jung, Bomi Park
Human adenovirus (HAdV) is a common cause of acute respiratory disease (ARD) and has raised significant concerns within the Korean military. Here, we conducted a comprehensive epidemiological analysis of HAdV-associated ARD by evaluating its prevalence, clinical outcomes, and prognosis.
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Mid-Term Strategic Plan for the Public Health and Medical Care Cooperation in the Korean Peninsula. J. Korean Med. Sci. (IF 4.5) Pub Date : 2024-01-29 Yun Seop Kim, Jin-Won Noh, Yo Han Lee, Sin Gon Kim
As extensive as the concept of and the resources required for 'Health for Korean Unification' are, and due to the limited access to information on the state of health and medical care in North Korea, discussion on 'Health for Korean Unification' has tended to be intermittent and lacked concrete action plans. In this article, we specifically distinguished areas of cooperation and selected five executable
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Application of the Time Derivative (TD) Method for Early Alert of Influenza Epidemics. J. Korean Med. Sci. (IF 4.5) Pub Date : 2024-01-29 Seul-Ki Kang, Woo-Sik Son, Bryan Inho Kim
In order to minimize the spread of seasonal influenza epidemic to communities worldwide, the Korea Disease Control and Prevention Agency has issued an influenza epidemic alert using the influenza epidemic threshold formula based on the results of the influenza-like illness (ILI) rate. However, unusual changes have occurred in the pattern of respiratory infectious diseases, including seasonal influenza
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Cardiac Magnetic Resonance Imaging Findings and Clinical Features of COVID-19 Vaccine-Associated Myocarditis, Compared With Those of Other Types of Myocarditis. J. Korean Med. Sci. (IF 4.5) Pub Date : 2024-01-29 Sang Gyun Kim, Jeong Yeop Lee, Won Gi Jeong, Jong Eun Lee, Yun-Hyeon Kim
To compare the clinical and cardiac magnetic resonance (CMR) imaging findings of coronavirus disease 2019 (COVID-19) vaccine-associated myocarditis (VAM) with those of other types of myocarditis.
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Antibiotic Resistance of Helicobacter pylori: Mechanisms and Clinical Implications. J. Korean Med. Sci. (IF 4.5) Pub Date : 2024-01-29 Md Hasanuzzaman, Chang Seok Bang, Eun Jeong Gong
Helicobacter pylori is a pathogenic bacterium associated with various gastrointestinal diseases, including chronic gastritis, peptic ulcers, mucosa-associated lymphoid tissue lymphoma, and gastric cancer. The increasing rates of H. pylori antibiotic resistance and the emergence of multidrug-resistant strains pose significant challenges to its treatment. This comprehensive review explores the mechanisms
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Retrospective Multicenter Analysis of Prognostic Risk Factors for One Year Recurrence in Patient With Renal Cell Carcinoma After Partial or Radical Nephrectomy: Results of Korean Renal Cancer Study Group (KRoCS) Database. J. Korean Med. Sci. (IF 4.5) Pub Date : 2024-01-22 Changil Choi, Minyong Kang, Seong Il Seo, Jungyo Suh, Cheryn Song, Jinsoo Chung, Sung Han Kim, Jae Young Park, Eu Chang Hwang, Chang Wook Jeong, Cheol Kwak, Jung Kwon Kim, Sung-Hoo Hong
We sought to identify prognostic risk factors for one year recurrence in patient with renal cell carcinoma (RCC) after partial or radical nephrectomy.
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The Impact of Obesity on Kidney Disease: Observational Cohort Study Analyzing 14,492 Kidney Biopsy Cases. J. Korean Med. Sci. (IF 4.5) Pub Date : 2024-01-22 Tae-Bum Kim, Shin Young Ahn, Jieun Oh, Eun Hui Bae, Ho Jun Chin, Myung-Gyu Kim, Sang Kyung Jo, Won Yong Cho, Se Won Oh
The obesity epidemic is associated with the emergence of new kidney diseases including obesity-related glomerulopathy (ORG) and metabolic syndrome-associated disorders. However, the effects of obesity on prevalence and outcome of biopsy-proven kidney disease are not well known.
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Effectiveness of Bivalent mRNA Booster Vaccine Against COVID-19 in Korea. J. Korean Med. Sci. (IF 4.5) Pub Date : 2024-01-22 Jin Gu Yoon, Jang Wook Sohn, Won Suk Choi, Seong-Heon Wie, Jacob Lee, Jin-Soo Lee, Hye Won Jeong, Joong Sik Eom, Hye Seong, Eliel Nham, Yu Jung Choi, Ji Yun Noh, Joon Young Song, Hee Jin Cheong, Woo Joo Kim
Bivalent booster mRNA vaccines containing the omicron-variant strains have been introduced worldwide in the autumn of 2022. Nevertheless, the omicron subvariants evoked another large coronavirus disease 2019 (COVID-19) pandemic wave in late 2022 and early 2023.
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Differences in Clinical Outcomes Between Hydroxyurea-Resistant and -Intolerant Polycythemia Vera Patients. J. Korean Med. Sci. (IF 4.5) Pub Date : 2024-01-22 Sung-Eun Lee, Junshik Hong, Soo-Mee Bang, Jinny Park, Chul Won Choi, Sung Hwa Bae, Min Kyoung Kim, Seug Yun Yoon, Sung-Yong Kim
Previous studies have suggested that patients with polycythemia vera (PV) who exhibit hydroxyurea-resistance (HU-R) and -intolerance (HU-I) may have distinct characteristics and clinical outcomes. However, to date, no studies have reported a comparison between these two groups or assessed prognostic factors in these patients.
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Prognostic Implication of Platelet Reactivity According to Left Ventricular Systolic Dysfunction Status in Patients Treated With Drug-Eluting Stent Implantation: Analysis of the PTRG-DES Consortium. J. Korean Med. Sci. (IF 4.5) Pub Date : 2024-01-22 Donghoon Han, Sun-Hwa Kim, Dong Geum Shin, Min-Kyung Kang, Seonghoon Choi, Namho Lee, Byeong-Keuk Kim, Hyung Joon Joo, Kiyuk Chang, Yongwhi Park, Young Bin Song, Sung Gyun Ahn, Jung-Won Suh, Sang Yeub Lee, Ae-Young Her, Young-Hoon Jeong, Hyo-Soo Kim, Moo Hyun Kim, Do-Sun Lim, Eun-Seok Shin, Jung Rae Cho
Coronary artery disease patients undergoing percutaneous coronary intervention (PCI) often exhibit reduced left ventricular ejection fraction (LVEF). However, the impact of LV dysfunction status in conjunction with platelet reactivity on clinical outcomes has not been previously investigated.
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Risk Factors of Postpartum Depression Among Korean Women: An Analysis Based on the Korean Pregnancy Outcome Study (KPOS). J. Korean Med. Sci. (IF 4.5) Pub Date : 2024-01-22 So Hyun Shim, Su Young Lee, Inkyung Jung, Seok-Jae Heo, You Jung Han, Dong Wook Kwak, Min Hyoung Kim, Hee Jin Park, Jin Hoon Chung, Ji Hyae Lim, Moon Young Kim, Dong Hyun Cha, Sung Shin Shim, Hee Young Cho, Hyun Mee Ryu
Postpartum depression (PPD) can negatively affect infant well-being and child development. Although the frequency and risk factors of PPD symptoms might vary depending on the country and culture, there is limited research on these risk factors among Korean women. This study aimed to elucidate the potential risk factors of PPD throughout pregnancy to help improve PPD screening and prevention in Korean
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Risk Factors and Trends in Adolescent's Suicide Attempt Rates Before and After the Coronavirus Disease 2019 Pandemic. J. Korean Med. Sci. (IF 4.5) Pub Date : 2024-01-22 Su-In Jung, Sang-Yeol Lee, Dae-Jin Kim, Chan-Mo Yang
Understanding adolescents' mental health during the coronavirus disease 2019 (COVID-19) pandemic and identifying those most at risk is an urgent public health challenge. This study explored the trend of suicide attempts and the association between loneliness, family financial stress, and suicide attempts during the COVID-19 pandemic among adolescents.
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Pediatric Extracorporeal Membrane Oxygenation in Korea: A Multicenter Retrospective Study on Utilization and Outcomes Spanning Over a Decade. J. Korean Med. Sci. (IF 4.5) Pub Date : 2024-01-22 Yu Hyeon Choi, Won Kyoung Jhang, Seong Jong Park, Hee Joung Choi, Min-Su Oh, Jung Eun Kwon, Beom Joon Kim, Ju Ae Shin, In Kyung Lee, June Dong Park, Bongjin Lee, Hyun Chung, Jae Yoon Na, Ah Young Choi, Joongbum Cho, Jaeyoung Choi, Hwa Jin Cho, Ah Young Kim, Yu Rim Shin, Joung-Hee Byun, Younga Kim
Over the last decade, extracorporeal membrane oxygenation (ECMO) use in critically ill children has increased and is associated with favorable outcomes. Our study aims to evaluate the current status of pediatric ECMO in Korea, with a specific focus on its volume and changes in survival rates based on diagnostic indications.
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Data Distribution: Normal or Abnormal? J. Korean Med. Sci. (IF 4.5) Pub Date : 2024-01-22 Farrokh Habibzadeh
Determining if the frequency distribution of a given data set follows a normal distribution or not is among the first steps of data analysis. Visual examination of the data, commonly by Q-Q plot, although is acceptable by many scientists, is considered subjective and not acceptable by other researchers. One-sample Kolmogorov-Smirnov test with Lilliefors correction (for a sample size ≥ 50) and Shapiro-Wilk
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Risk Factors for Unfavorable Outcomes of Tuberculosis in Korea: Implications for Patient-Centered Care in Tuberculosis Treatment. J. Korean Med. Sci. (IF 4.5) Pub Date : 2024-01-15 Hye Young Hong, Youngmok Park, Seung Hyun Yong, Ala Woo, Ah Young Leem, Su Hwan Lee, Kyung Soo Chung, Sang Hoon Lee, Song Yee Kim, Eun Young Kim, Ji Ye Jung, Moo Suk Park, Young Sam Kim, Sung Jae Shin, Young Ae Kang
The treatment success rate for tuberculosis (TB) has stagnated at 80-81% in South Korea, indicating unsatisfactory outcomes. Enhancing treatment success rate necessitates the development of individualized treatment approaches for each patient. This study aimed to identify the risk factors associated with unfavorable treatment outcomes to facilitate tailored TB care.
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A Multicenter Analysis of Clinical Features and Long-Term Outcomes of POEMS Syndrome in Korea. J. Korean Med. Sci. (IF 4.5) Pub Date : 2024-01-15 Hye Won Kook, Ji Eun Jang, Chang-Ki Min, Dok Hyun Yoon, Kihyun Kim, Soo-Mee Bang, Yong Park, Jae Hoon Lee, Sung-Soo Yoon, Jin Seok Kim
POEMS syndrome is a rare form of plasma cell dyscrasia characterized by polyneuropathy, organomegaly, endocrinopathy, monoclonal proteins, and skin changes. Owing to its low incidence, there are few reports regarding this syndrome. This multicenter study included 84 patients diagnosed with POEMS syndrome in South Korea.
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COVID-19 Mortality and Severity in Cancer Patients and Cancer Survivors. J. Korean Med. Sci. (IF 4.5) Pub Date : 2024-01-15 Jae-Min Park, Hye Yeon Koo, Jae-Ryun Lee, Hyejin Lee, Jin Yong Lee
We aimed to investigate mortality, severity, and risk of hospitalization in coronavirus disease 2019 (COVID-19) patients with cancer.
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Factors Affecting the Preference for Hospitals Over Clinics in Primary Care in Korea. J. Korean Med. Sci. (IF 4.5) Pub Date : 2024-01-15 Agnus M Kim, Jin-Seok Lee
While the effect of gatekeeping was extensively studied, few efforts have been made to explain why the measures to strengthen gatekeeping do not work well in some countries. This study examined the patient factors related to the choice of level of health care facilities for outpatient care in Korea.
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JAK2 Loss Arising From Tumor-Spread-Through-Air-Spaces (STAS) Promotes Tumor Progression by Suppressing CD8+ T Cells in Lung Adenocarcinoma: A Machine Learning Approach. J. Korean Med. Sci. (IF 4.5) Pub Date : 2024-01-15 Soohwan Choi, Hyung Suk Kim, Kyueng-Whan Min, Yung-Kyun Noh, Jeong-Yeon Lee, Ji-Yong Moon, Un Suk Jung, Mi Jung Kwon, Dong-Hoon Kim, Byoung Kwan Son, Jung Soo Pyo, Sun Kyun Ro
Tumor spread through air spaces (STAS) is a recently discovered risk factor for lung adenocarcinoma (LUAD). The aim of this study was to investigate specific genetic alterations and anticancer immune responses related to STAS. By using a machine learning algorithm and drug screening in lung cancer cell lines, we analyzed the effect of Janus kinase 2 (JAK2) on the survival of patients with LUAD and
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First-in-Human Study for Evaluating the Accuracy of Smart Ring Based Cuffless Blood Pressure Measurement. J. Korean Med. Sci. (IF 4.5) Pub Date : 2024-01-15 Jihoon Kim, Sung-A Chang, Seung Woo Park
Recently, a ring-type cuffless blood pressure (BP) measuring device has been developed. This study was a prospective, single arm, first-in-human pivotal trial to evaluate accuracy of BP measurement by the new device.
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Prognostic Factors for Predicting Post-COVID-19 Condition in Patients With COVID-19 in an Outpatient Setting. J. Korean Med. Sci. (IF 4.5) Pub Date : 2024-01-15 Myeong Geun Choi, Young Woong Joo, Min-Ho Kim, Sojung Park, Yune-Young Shin, Eun Mi Chun
Although data on post-coronavirus disease 2019 (COVID-19) conditions are extensive, the prognostic factors affecting symptom duration in non-hospitalized patients with COVID-19 are currently not well known. We aimed to investigate the various prognostic factors affecting symptom duration among outpatients with COVID-19.
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Combination Analysis of PCDHGA12 and CDO1 DNA Methylation in Bronchial Washing Fluid for Lung Cancer Diagnosis. J. Korean Med. Sci. (IF 4.5) Pub Date : 2024-01-15 Se Jin Park, Daeun Kang, Minhyeok Lee, Su Yel Lee, Young Gyu Park, TaeJeong Oh, Seunghyun Jang, Wan Jin Hwang, Sun Jung Kwon, Sungwhan An, Ji Woong Son, In Beom Jeong
When suspicious lesions are observed on computer-tomography (CT), invasive tests are needed to confirm lung cancer. Compared with other procedures, bronchoscopy has fewer complications. However, the sensitivity of peripheral lesion through bronchoscopy including washing cytology is low. A new test with higher sensitivity through bronchoscopy is needed. In our previous study, DNA methylation of PCDHGA12
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Socioeconomic Disparities in the Association Between All-Cause Mortality and Health Check-Up Participation Among Healthy Middle-Aged Workers: A Nationwide Study. J. Korean Med. Sci. (IF 4.5) Pub Date : 2023-12-25 Byungyoon Yun, Juyeon Oh, Jaesung Choi, Laura S Rozek, Heejoo Park, Juho Sim, Yangwook Kim, Jongmin Lee, Jin-Ha Yoon
This study assessed the relationship between non-participation in health check-ups and all-cause mortality and morbidity, considering socioeconomic status.
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An Analysis of the Demographics and Clinical Characteristics of Transgender and Intersex Populations in Korea: A Retrospective Study Using HIRA Database. J. Korean Med. Sci. (IF 4.5) Pub Date : 2023-12-25 Dong-Jin Kim, Na-Hyun Hwang, Ji Yoon Lee, Seung Ha Park, Byung-Il Lee, Eul-Sik Yoon
Transgender and intersex populations have long remained under-documented in South Korea, largely due to the absence of comprehensive epidemiological data. With increasing societal acknowledgment, there's an urgent need to understand the demographics and health challenges faced by these communities.