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Clinical characteristics and long-term outcomes of patients with heart failure with improved ejection fraction. First Polish experience from LECRA-HF registry Adv. Med. Sci. (IF 2.7) Pub Date : 2024-03-04 Konrad Stępień, Karol Nowak, Natalia Kachnic, Aleksandra Karcińska, Alicia del Carmen Yika, Jakub Furczyński, Michael Platschek, Maria Skorupa, Zuzanna Wyleciał, Jarosław Zalewski, Jadwiga Nessler
Heart failure (HF) with improved ejection fraction (HFimpEF) is a new category of HF introduced in the newest European Society of Cardiology guidelines. However, clinical characteristics and long-term outcomes of HFimpEF patients remain insufficiently elucidated. We sought to characterize Polish HFimpEF patients and determine their long-term mortality. Of 1186 patients enrolled in the single-center
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Effects of intensity-modulated radiotherapy combined with chemotherapy and prognostic factors in patients with locally advanced oesophageal cancer Adv. Med. Sci. (IF 2.7) Pub Date : 2024-03-02 Yao Ou, Hongbo Li, Dan Yang, Lijun Suo
We explored the efficacy and influencing factors of chemoradiotherapy and radiotherapy alone in patients with locally advanced oesophageal squamous cell carcinoma. We retrospectively analysed 226 locally advanced oesophageal squamous cell carcinoma patients who underwent chemoradiotherapy and radiotherapy alone. Univariate and multivariate Cox regression analyses were used to analyse the impact of
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Effectiveness of high-fat and high-carbohydrate diets on body composition and maximal strength after 15 weeks of resistance training Adv. Med. Sci. (IF 2.7) Pub Date : 2024-02-28 Marek Kruszewski, Artur Kruszewski, Rafał Tabęcki, Stanisław Kuźmicki, Krzysztof Stec, Tadeusz Ambroży, Maksim Olegovich Aksenov, Maciej Merchelski, Tomasz Danielik
The aim of this study was to compare High Carbohydrates Low Fat (HCLF) and Low Carbohydrate High Fat (LCHF) diets in terms of changes in body composition and maximal strength. The study involved 48 men aged 25 ± 2.5, divided into two groups, one of which (n = 23) was following the LCHF diet and the other (n = 25) the HCLF diet. Both groups performed the same resistance training protocol for 15
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The impact of wound-healing assay, phorbol myristate acetate (PMA) stimulation and siRNA-mediated FURIN gene silencing on endogenous retroviral ERVW-1 expression level in U87-MG astrocytoma cells Adv. Med. Sci. (IF 2.7) Pub Date : 2024-02-23 Grzegorz Machnik, Łukasz Bułdak, Karolina Zapletal-Pudełko, Beniamin Oskar Grabarek, Rafał Staszkiewicz, Dawid Sobański, Bogusław Okopień
Human endogenous retroviruses (HERVs) are ubiquitous genomic sequences. Normally dormant HERVs, undergo reactivation by environmental factors. This deregulation of HERVs’ transcriptional equilibrium correlates with medical conditions such as multiple sclerosis (MS). Here we sought to explore whether exposing the U-87 MG astrocytoma cells to traumatic injury deregulates the expression of HERV-W family
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Potential of the postoperative lymphocyte-to-monocyte and monocyte-to-red blood cell ratio in predicting locoregional and distant metastases after breast cancer resection - Retrospective study Adv. Med. Sci. (IF 2.7) Pub Date : 2024-02-22 Joanna Grupińska, Magdalena Budzyń, Jakub Janowski, Jacek Brzeziński, Bogna Gryszczyńska, Ewa Leporowska, Dorota Formanowicz, Witold Kycler
Breast cancer is the most common malignancy with high recurrence and mortality rates in women. There are still insufficient biomarkers to predict disease prognosis. Therefore, the present study aimed to investigate the clinical significance of postoperative hematologic parameters and their derivatives in patients with breast cancer who underwent tumor resection. The clinicopathological and laboratory
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Critical roles of PAI-1 in lipopolysaccharide-induced acute lung injury Adv. Med. Sci. (IF 2.7) Pub Date : 2024-02-21 Miao Li, Juan Song, Xinjun Tang, Jing Bi, Yufan Li, Cuicui Chen, Nana Feng, Yuanlin Song, Linlin Wang
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Can non-invasive cardiac hemodynamics and fluid content system (NICaS) parameters predict Acute Heart Failure outcomes in Caucasian and Asian patients in the emergency department? Adv. Med. Sci. (IF 2.7) Pub Date : 2024-02-21 Muhammad Anshory, Win Sen Kuan, M. Saifur Rohman, Yoga Waranugraha, Putri Annisa Kamila, Agustin Iskandar, Hani Susianti, Ying Wei Yau, Crystal Harn Wei Soh, Khalid Mohammed Ali, Mui Teng Chua, Salvatore Di Somma
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Metformin improves d-galactose induced premature ovarian insufficiency through PI3K-Akt-FOXO3a pathway Adv. Med. Sci. (IF 2.7) Pub Date : 2024-02-21 Fatima Ellibishy, Maha Tarek, Marwa M. Abd-Elsalam, Nesreen Elgayar, Wesam El bakly
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The association between growth differentiation factor 15 and presence and severity of coronary atherosclerosis Adv. Med. Sci. (IF 2.7) Pub Date : 2024-02-17 Emrah Ozdemir, Berna Stavileci, Bahar Ozdemir, Faik Alper Aksoy, Serkan Kahraman, Ceyla Zeynep Colakoglu Gevher, Murat Ziyrek, Ali Dogan
Growth differentiation factor 15 (GDF-15) is a member of the transforming growth factor beta superfamily and is faintly expressed under healthy conditions. GDF-15 is markedly elevated in a variety of diseases, including coronary artery disease (CAD), atrial fibrillation and heart failure. Here, we aimed to investigate the association of GDF-15 with the extent and severity of CAD in patients with stable
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Transcriptome profiling as a biological marker for bipolar disorder sub-phenotypes Adv. Med. Sci. (IF 2.7) Pub Date : 2024-02-17 Joanna Pawlak, Aleksandra Szczepankiewicz, Maria Skibińska, Beata Narożna, Paweł Kapelski, Przemysław Zakowicz, Karolina Gattner, Dominik Spałek, Łukasz Mech, Monika Dmitrzak-Węglarz
Bipolar affective disorder (BP) causes major functional impairment and reduced quality of life not only for patients, but also for many close relatives. We aimed to investigate mRNA levels in BP patients to find differentially expressed genes linked to specific clinical course variants; assuming that several gene expression alterations might indicate vulnerability pathways for specific course and severity
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Changes in arterial pH do not explain the reductions in ionised calcium observed during COVID-19 infection Adv. Med. Sci. (IF 2.7) Pub Date : 2024-02-15 John Scott Frazer, Robin Lucas-Evans, Asghar Dayala, Dennis A. Mlangeni
Hypocalcaemia predicts coronavirus disease 2019 (COVID-19) severity and mortality. We hypothesized an association between respiratory alkalosis secondary to hypoxia and low ionised calcium (iCa) concentration in patients with COVID-19. Arterial blood gas samples taken from January 2019 to March 2021 were retrospectively matched with infection status. Principal components regression was undertaken to
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Effect of advanced glycation end-products in a wide range of medical problems including COVID-19 Adv. Med. Sci. (IF 2.7) Pub Date : 2024-02-08 Agnieszka Bronowicka-Szydełko, Kinga Gostomska-Pampuch, Aleksandra Kuzan, Jadwiga Pietkiewicz, Małgorzata Krzystek-Korpacka, Andrzej Gamian
Glycation is a physiological process that determines the aging of the organism, while in states of metabolic disorders it is significantly intensified. High concentrations of compounds such as reducing sugars or reactive aldehydes derived from lipid oxidation, occurring for example in diabetes, atherosclerosis, dyslipidemia, obesity or metabolic syndrome, lead to increased glycation of proteins, lipids
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Stereotactic body radiation therapy (SBRT) for the treatment of primary breast cancer in patients not undergoing surgery Adv. Med. Sci. (IF 2.7) Pub Date : 2024-02-01 Ewa Zabrocka, John D. Roberson, Collin Noldner, Jinkoo Kim, Rushil Patel, Samuel Ryu, Alexander Stessin
The purpose was to explore the role of stereotactic body radiation therapy (SBRT) in providing local control (LC) for primary breast cancer in patients unable to undergo surgery. Between 2015 and 2019, 13 non-surgical candidates with 14 lesions were treated with SBRT for primary breast cancer. In 4 cases, SBRT was used after whole breast radiation therapy (WBRT; 40–50 Gy/20–25 fractions). SBRT dose
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Progesterone signaling in uterine leiomyoma biology: Implications for potential targeted therapy Adv. Med. Sci. (IF 2.7) Pub Date : 2024-01-25 Weronika Szucio, Piotr Bernaczyk, Donata Ponikwicka-Tyszko, Gabriela Milewska, Adam Pawelczyk, Sławomir Wołczyński, Nafis A. Rahman
Uterine leiomyomas (ULs) are the most common benign smooth muscle cell steroid-dependent tumors that occur in women of reproductive age. Progesterone (P4) is a major hormone that promotes the ULs development and growth. P4 action in ULs is mediated mainly by its nuclear progesterone receptors (PGRs), although rapid non-genomic responses have also been observed. Data on the membrane progesterone receptors
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Liver fibrosis assessment in pediatric population - can ultrasound elastography be an alternative method to liver biopsy? A systematic review Adv. Med. Sci. (IF 2.7) Pub Date : 2024-01-09 Aleksandra Medyńska-Przęczek, Anna Stochel-Gaudyn, Andrzej Wędrychowicz
Liver diseases of various etiologies are becoming increasingly common in the pediatric population. So far, the gold diagnostic standard in these disorders is liver biopsy. This procedure is invasive, painful and requires general anesthesia in this group of patients. Due to the continuous development of new research techniques, such as liver elastography, it is necessary to evaluate them in the context
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A new tidal breathing measurement device detects bronchial obstruction during methacholine challenge test Adv. Med. Sci. (IF 2.7) Pub Date : 2023-12-13 Andreas Zachariades, Nadav Bachar, Noy Danino, Inbal Shafran, Ronit Shtrichman, Gregory Shuster, Wieland Voigt
Purpose Bronchial hyperresponsiveness (BHR), a hallmark of bronchial asthma, is typically diagnosed through a methacholine inhalation test followed by spirometry, known as the methacholine challenge test (MCT). While spirometry relies on proper patients' cooperation and precise execution of forced breathing maneuvers, we conducted a comparative analysis with the portable nanomaterial-based sensing
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Coding RNA expression profile and transcription factor analysis of H.pylori-associated chronic atrophic gastritis Adv. Med. Sci. (IF 2.7) Pub Date : 2023-11-08 Xinguo Wang, Juan Dong, Hao Sheng, Xingting Ma, Lazati Baheti, Jie Xu
Purpose Atrophic gastritis, one of the processes leading to gastric cancer (GC), is closely related to Helicobacter pylori (HP) infection. This study aimed to understand how HP causes chronic inflammation that leads to ulcers and stomach problems. Methods Twenty-eight CAG patients were included in the study (9 HP-infected and 19 HP-uninfected). Endoscopy, histopathology, and high-throughput mRNA sequencing
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The use of non-invasive respiratory assistance to facilitate bronchofiberoscopy performance in patients with hypoxemic (type one) respiratory failure - Study protocol Adv. Med. Sci. (IF 2.7) Pub Date : 2023-11-07 Aleksandra Oraczewska, Szczepan Cofta, Adam Warcholiński, Ewa Trejnowska, Grzegorz Brożek, Andrzej Swinarew, Daiana Stolz, Raffaele Scala, Adam Barczyk, Szymon Skoczyński
Purpose Bronchofiberoscopy (FOB) is a procedure routinely performed for: lung cancer, obstruction, interstitial diseases, foreign bodies’ removal, airway clearance, and hemoptysis. It causes acute airway narrowing leading to respiratory and cardiovascular stress. Due to increasing number of ill patients with respiratory failure (RF), conventional oxygen therapy (COT) is frequently insufficient to assure
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May noninvasive mechanical ventilation and/ or continuous positive airway pressure increase the bronchoalveolar lavage salvage in patients with pulmonary diseases? Randomized clinical trial - Study protocol Adv. Med. Sci. (IF 2.7) Pub Date : 2023-11-07 Anna Danel, Ewelina Tobiczyk, Adam Warcholiński, Marzena Trzaska-Sobczak, Andrzej Swinarew, Grzegorz Brożek, Ewa Trejnowska, Halina Batura-Gabryel, Antonina Jedynak, Raffaele Scala, Adam Barczyk, Szczepan Cofta, Szymon Skoczyński
Purpose Bronchoalveolar lavage (BAL) procedure is a useful tool in the diagnosis of patients with interstitial lung disease (ILD) and is helpful in clinical research of chronic obstructive pulmonary disease (COPD) patients. Still little is known about predictors of poor BAL salvage. The trial aims to find the most efficient way to improve BAL recovery. Material and methods Our study is a prospective
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Heat shock proteins in cancer – Known but always being rediscovered: Their perspectives in cancer immunotherapy Adv. Med. Sci. (IF 2.7) Pub Date : 2023-11-04 Alena Mazurakova, Zuzana Solarova, Lenka Koklesova, Martin Caprnda, Robert Prosecky, Artur Khakymov, Denis Baranenko, Peter Kubatka, Ladislav Mirossay, Peter Kruzliak, Peter Solar
Heat shock proteins (HSPs) represent cellular chaperones that are classified into several families, including HSP27, HSP40, HSP60, HSP70, and HSP90. The role of HSPs in the cell includes the facilitation of protein folding and maintaining protein structure. Both processes play crucial roles during stress conditions in the cell such as heat shock, degradation, and hypoxia. Moreover, HSPs are important
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A comprehensive review of ACE2, ACE1, TMPRSS2 and IFITM3 gene polymorphisms and their effect on the severity of COVID-19 Adv. Med. Sci. (IF 2.7) Pub Date : 2023-11-03 Parisa Sahranavard-Pirbazari, Azin Khoshghiafeh, Mohammad Javad Kamali, Hanieh Esfandiar, Marzieh Bakhtiari, Mohamadreza Ahmadifard
Recent events have raised concerns about the outbreak of a pandemic by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). An infection caused by a virus can provoke an inflammatory reaction, which can result in severe lung damage, failure of several organs, and death. The unique genetic makeup of each individual may be a component in the development of each of these responses. In this
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Combination therapy along with mesenchymal stem cells in wound healing; the state of the art Adv. Med. Sci. (IF 2.7) Pub Date : 2023-11-02 Hossein Daneste, Linda Mohammadzadeh Boukani, Narges Ramezani, Fatemeh Asadi, Haider Kamil Zaidan, Azita Sadeghzade, Maedeh Ehsannia, Ali Azarashk, Nasim Gholizadeh
Mesenchymal stem cells (MSCs) are being increasingly used in various therapeutic applications including skin tissue repair and wound healing. The positive effects of the MSCs therapy are largely elicited by immunomodulation, increasing angiogenesis, supporting extracellular matrix (ECM) and thus favoring skin structure. However, the therapeutic competences of MSC-based therapies are somewhat hindered
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Investigation of the effects of urotensin II receptors in LPS-induced inflammatory response in HUVEC cell line through calcineurin/NFATc/IL-2 pathway Adv. Med. Sci. (IF 2.7) Pub Date : 2023-10-30 Zekai Halici, Vedat Bulut, Elif Cadirci, Muhammed Yayla
Purpose The effect of urotensin II (U-II), a powerful endogenous vasoconstrictor substance, on the immune system and its mediators is very important. It was herein aimed to demonstrate the possible relationship between the calcineurin/nuclear factor of activated T-cells cytoplasmic 1/interleukin-2 (CaN/NFATc/IL-2) pathway and urotensin receptors (UTRs) in inflammatory response due to lipopolysaccharide
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Ceramides and their roles in programmed cell death Adv. Med. Sci. (IF 2.7) Pub Date : 2023-10-20 Martina Bago Pilátová, Zuzana Solárová, Roman Mezencev, Peter Solár
Programmed cell death plays a crucial role in maintaining the homeostasis and integrity of multicellular organisms, and its dysregulation contributes to the pathogenesis of many diseases. Programmed cell death is regulated by a range of macromolecules and low-molecular messengers, including ceramides. Endogenous ceramides have different functions, that are influenced by their localization and the presence
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Extracellular vesicle-derived circHIPK3: Novel diagnostic biomarker for lung cancer Adv. Med. Sci. (IF 2.7) Pub Date : 2023-10-20 Yingying Zhu, Li Shen, Qiuyan Xia, Heyun Tao, Zhanguo Liu, Mengdie Wang, Xiaomin Zhang, Jun Zhang, Jian Lv
Purpose Lung cancer (LC) is a common malignancy worldwide. A great number of circular RNAs (circRNAs) have been identified that serve crucial roles in cancer development. Extracellular vesicles (EVs) and their contents have been shown to be biomarkers for the diagnosis and prognosis of LC. Thus, we intended to clarify the functional role of EVs-derived circRNA homology domain interacting protein kinase
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Monocyte-to-lymphocyte ratio correlates with parathyroid hormone concentration in patients with severe symptomatic aortic stenosis Adv. Med. Sci. (IF 2.7) Pub Date : 2023-10-12 Anna Olasińska-Wiśniewska, Tomasz Urbanowicz, Kajetan Grodecki, Piotr Kübler, Bartłomiej Perek, Marek Grygier, Marcin Misterski, Maciej Walczak, Mateusz Szot, Marek Jemielity
Purpose The normal healthy valve is devoid of inflammatory cells, however background of aortic stenosis (AS) may include inflammatory processes. Moreover, the link between hyperparathyroidism and heart failure is postulated. Simple whole blood analysis with indices is a beneficial tool in cardiovascular diseases’ assessment. The purpose of the study was to evaluate correlation between parathyroid hormone
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Mechanism of molecular interaction of sitagliptin with human DPP4 enzyme - New Insights Adv. Med. Sci. (IF 2.7) Pub Date : 2023-10-12 Michelangelo Bauwelz Gonzatti, José Edvar Monteiro Júnior, Antônio José Rocha, Jonathas Sales de Oliveira, Antônio José de Jesus Evangelista, Fátima Morgana Pio Fonseca, Vânia Marilande Ceccatto, Ariclécio Cunha de Oliveira, José Ednésio da Cruz Freire
Purpose Dipeptidyl peptidase 4 (DPP4) inactivates a range of bioactive peptides. The cleavage of insulinotropic peptides and glucagon-like peptide 1 (GLP1) by DPP4 directly influences glucose homeostasis. This study aimed to describe the mode of interaction between sitagliptin (an antidiabetic drug) and human DPP4 using in silico approaches. Materials and methods Docking studies were conducted using
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CRISPR/Cas9-mediated high-mobility group A2 knockout inhibits cell proliferation and invasion in papillary thyroid carcinoma cells Adv. Med. Sci. (IF 2.7) Pub Date : 2023-10-12 Shan Jin, Hong Yong, Yousheng Liu, Wuyuntu Bao
Purpose Metastasis and recurrence are the prognostic risk factor in patients with thyroid carcinoma. High-mobility group A2 (HMGA2) protein plays a crucial role in papillary thyroid carcinoma (PTC) metastasis. The aim of this study was to investigate the mechanisms underlying the HMGA2 effect on PTC cell proliferation and invasion. Materials and methods We used the CRISPR/Cas9 system to perform knockout
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Biological, genetic and epigenetic markers in ulcerative colitis Adv. Med. Sci. (IF 2.7) Pub Date : 2023-10-07 Gemma Caliendo, Giovanna D'Elia, Jasmine Makker, Luana Passariello, Luisa Albanese, Anna Maria Molinari, Maria Teresa Vietri
In this review, we have summarized the existing knowledge of ulcerative colitis (UC) markers based on current literature, specifically, the roles of potential new biomarkers, such as circulating, fecal, genetic, and epigenetic alterations, in UC onset, disease activity, and in therapy response. UC is a complex multifactorial inflammatory disease. There are many invasive and non-invasive diagnostic
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The TGFBI gene and protein expression in topotecan resistant ovarian cancer cell lines Adv. Med. Sci. (IF 2.7) Pub Date : 2023-10-06 Karolina Wojtowicz, Monika Świerczewska, Michał Nowicki, Radosław Januchowski
Purpose The primary limiting factor in achieving cures for patients with cancer, particularly ovarian cancer, is drug resistance. The mechanisms of drug resistance of cancer cells during chemotherapy may include compounds of the extracellular matrix, such as the transforming growth factor-beta-induced protein (TGFBI). In this study, we aimed to analyze the TGFBI gene and protein expression in different
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A mouse model of food allergy permitting skin and nasal symptoms Adv. Med. Sci. (IF 2.7) Pub Date : 2023-10-04 Takafumi Morinaga, Takuya Yamamoto, Yukio Sugimoto
Purpose Developing experimental animal models that show clinical symptoms and methods for quantitative and objective evaluation are important for understanding food allergies. Therefore, this study aimed to develop an ovalbumin (OVA)-induced mouse model of food allergy and a useful method to evaluate the symptoms of food allergy. Material/methods Mice were sensitized via intraperitoneal injection of
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Adjunctive use of platelet-rich fibrin in surgical treatment of furcation defects: A systematic review Adv. Med. Sci. (IF 2.7) Pub Date : 2023-09-25 Anna Skurska, Marek Chwiedosik, Zuzanna Ślebioda
Periodontitis is an infectious disease characterized by the inflammatory destruction of the tooth supporting tissues. In multi-rooted teeth, this process leads to periodontal destruction within furcations creating defects demanding in terms of treatment. Regeneration of class II furcation involvement, although possible, is considered an unpredictable procedure, especially in terms of the bone fill
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Frontal EEG alterations induced by hippocampal amyloid pathology in rats Adv. Med. Sci. (IF 2.7) Pub Date : 2023-09-25 Enis Hidisoglu, Giuseppe Chiantia
Purpose In this study, it was aimed to determine the dose-dependent effects of hippocampal amyloid beta (Aβ) on frontal EEG activity and to elucidate the possible non-invasive biomarkers by recording spontaneous EEG in free-moving rats. Material and methods Male albino Wistar rats aged 3 months were randomly divided into 4 groups (n = 8 for each group), obtained by intrahippocampal injection of saline
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Genetic aberrations of homologous recombination repair pathways in prostate cancer: The prognostic and therapeutic implications Adv. Med. Sci. (IF 2.7) Pub Date : 2023-09-25 Hamidreza Saeidi, Ikmal Hisyam Bakrin, Chandramathi Samudi Raju, Patimah Ismail, Mohsen Saraf, Mohd Ghani Khairul-Asri
Prostate cancer (PC) is the second most common cancer in men worldwide. Homologous recombination repair (HRR) gene defects have been identified in a significant proportion of metastatic castration-resistant PC (mCRPC) and are associated with an increased risk of PC and more aggressive PC. Importantly, it has been well-documented that poly ADP-ribose polymerase (PARP) inhibition in cells with HR deficiency
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Safety and efficacy of melatonin as an adjuvant therapy in COVID-19 patients: Systematic review and meta-analysis Adv. Med. Sci. (IF 2.7) Pub Date : 2023-09-22 Amira Mohamed Taha, Sara Adel Abdelkader Saed, Mostafa Hossam-Eldin Moawad, Wesam Abd El-Tawab Moawad, Tala Al-hejazi, Yosra Mousa, Ramaswamy Sharma, Russel J. Reiter
Background Melatonin might be beneficial to coronavirus disease 2019 (COVID-19) patients in terms of both prevention and treatment. We investigated how melatonin affected various clinical and laboratory results in COVID-19 patients. Methods PubMed, Scopus, Cochrane Library and Web of Science databases were utilized for searching eligible articles fulfilling our inclusion criteria up to December 2022
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Alternative donor strategy in unrelated hematopoietic stem cell transplantation – outcome with mismatched donors Adv. Med. Sci. (IF 2.7) Pub Date : 2023-09-22 Zorana Grubic, Marija Maskalan, Marija Burek Kamenaric, Lana Desnica, Mirta Mikulic, Katarina Stingl Jankovic, Nadira Durakovic, Ranka Serventi Seiwerth, Radovan Vrhovac, Renata Zunec
Purpose This study retrospectively investigated the association between the level of human leukocyte antigen (HLA) mismatches (MMs), direction of disparities and differences at particular HLA locus on clinical outcomes of hematopoietic stem cell transplantation (HSCT). Investigated outcomes were overall survival (OS) and disease-free survival (DFS), graft-versus-host disease (GvHD), relapse and non-relapse
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Patterned edge-illuminated display for clinical examination of visual evoked potentials using simultaneous magnetic resonance imaging Adv. Med. Sci. (IF 2.7) Pub Date : 2023-09-14 Łukasz Lisowski, Łukasz Łabieniec, Jolanta Lisowska, Wojciech Obrębski, Joanna Konopińska, Krzysztof Szymański
Purpose Commonly used technologies for visual pattern stimulation cannot operate in a magnetic resonance imaging room because they can interfere with the operation of the scanner and are vulnerable to its electromagnetic and magnetic fields. The aim of this single-center prospective observational study was to introduce a novel, structurally uncomplicated, easy-to-maintain, patterned edge-illuminated
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Kidney morphology and renal expression of aquaporins 2, 3 and 4 during cerulein – Induced chronic pancreatitis in pigs Adv. Med. Sci. (IF 2.7) Pub Date : 2023-09-13 Katarzyna Michałek, Patrycja Oberska, Maciej Murawski, Tomasz Schwarz, Ewa Tomaszewska, Siemowit Muszyński, Małgorzata Świątkiewicz, Łukasz Korytkowski, Joanna Bonior, Mateusz Zelent, David Salako-Adeoye Ayomide, Marta Grabowska
Purpose Chronic pancreatitis (CP) is associated with serious complications and reduced quality of life. Kidney failure is a frequent complication of acute pancreatitis (AP), however limited information is available regarding the impact of CP on this condition. In the kidney, 9 aquaporins (AQPs) are expressed to maintain body water homeostasis and concentrate urine. The purpose of this study was to
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The melatonin agonist ramelteon attenuates bleomycin-induced lung fibrosis by suppressing the NLRP3/TGF-Β1/HMGB1 signaling pathway Adv. Med. Sci. (IF 2.7) Pub Date : 2023-09-14 Pelin Aydin, Zeynep B. Aksakalli-Magden, Maide S. Civelek, Sevgi Karabulut-Uzuncakmak, Behzad Mokhtare, Mustafa Ozkaraca, Fatih Alper, Zekai Halici
Purpose The possible effects of ramelteon, a melatonin receptor agonist on bleomycin-induced lung fibrosis were analyzed via transforming growth factor β1 (TGF-β1), the high mobility group box 1 (HMGB1) and Nod-like receptor pyrin domain-containing 3 (NLRP3) which are related to the fibrosis process. Materials and methods Bleomycin (0.1 mL of 5 mg/kg) was administered by intratracheal instillation
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The profile of adipokines associated with fibrosis and impaired microcirculation in systemic sclerosis Adv. Med. Sci. (IF 2.7) Pub Date : 2023-09-09 Anna Niemczyk, Anna Waśkiel-Burnat, Michał Zaremba, Joanna Czuwara, Lidia Rudnicka
Purpose Adipokines belong to a group of molecules mostly produced by adipose tissue. Abnormalities in the secretion of several adipokines have already implicated to play a pathogenic role in systemic sclerosis (SSc). However, the possible role of numerous molecules still needs to be clarified. The aim of the study was to determine whether the altered level of selected circulating adipokines might correlate
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Fascin in migration and metastasis of breast cancer cells – A review Adv. Med. Sci. (IF 2.7) Pub Date : 2023-09-02 Magdalena Izdebska, Wioletta Zielińska, Adrian Krajewski, Alina Grzanka
Cancer cell migration and metastasis are the biggest problems in the treatment of cancer patients. The most aggressive breast cancer (BC) is the triple-negative type. Therefore, effective therapeutic targets that limit cell migration are sought. One such target may be fascin, as its overexpression is characteristic to triple-negative breast cancer. The high level of fascin enables the formation of
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Sodium accumulation in the skin is associated with higher density of skin lymphatic vessels in patients with arterial hypertension Adv. Med. Sci. (IF 2.7) Pub Date : 2023-08-26 Angelika Chachaj, Ivana Stanimirova, Mariusz Chabowski, Agnieszka Gomułkiewicz, Paweł Hodurek, Natalia Glatzel-Plucińska, Mateusz Olbromski, Aleksandra Piotrowska, Aleksandra Kuzan, Jędrzej Grzegrzółka, Katarzyna Ratajczak-Wielgomas, Aleksandra Nowak, Ewa Szahidewicz-Krupska, Jerzy Wiśniewski, Mariusz A. Bromke, Marzenna Podhorska-Okołów, Andrzej Gamian, Dariusz Janczak, Piotr Dzięgiel, Andrzej Szuba
Purpose Recent studies, conducted mainly on the rodent model, have demonstrated that regulatory pathway in the skin provided by glycosaminoglycans, nuclear factor of activated T cells 5 (NFAT5), vascular endothelial growth factor C (VEGF-C) and process of lymphangiogenesis may play an important role in extrarenal regulation of sodium (Na+) balance, body water volume, and blood pressure. We aimed to
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Pulmonary embolism in COVID-19 pneumonia patients admitted to temporary hospital - The follow-up study Adv. Med. Sci. (IF 2.7) Pub Date : 2023-08-24 Tomasz Lewczuk, Remigiusz Kazimierczyk, Bozena Sobkowicz, Anna Lisowska
Purpose Coronavirus disease 2019 (COVID-19) is linked with major coagulation disorders, especially higher risk of developing pulmonary embolism (PE). Our study summarizes COVID-19 patients’ management with concomitant PE during the first weeks of pandemic and underlines the importance of D-dimer concentration assessment at admission in terms of prognosis. Material and methods Study group consisted
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Accuracy and availability of automated urine output monitoring in the operating room using a smart scale Adv. Med. Sci. (IF 2.7) Pub Date : 2023-08-22 Se Kwang Oh, Donghyun Kim, Jiyoung Kim, Boram You, Han Seul Oh, Chiheon Kwon, Jinsun Lee, Sang-Ha Oh
Purpose Urine output (UO) is an important intraoperative parameter that is not yet electronically monitored. We compared an automatic urinometer (AU) based on a smart scale with a manual urinometer (MU). Patients and methods This prospective study investigated the hourly UO of 35 preoperative patients with an indwelling urinary catheter using AU, MU, and cylinder measurements. Data were analyzed using
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Some pleiotropic effects of statins on hepatocellular carcinoma cells: Comparative study on atorvastatin, rosuvastatin and simvastatin Adv. Med. Sci. (IF 2.7) Pub Date : 2023-07-19
Purpose For many years, statins have been the most commonly used drugs in cholesterol-lowering therapy. In addition to these therapeutic effects, statins exhibit other, pleiotropic effects that can be beneficial, but also harmful to cells and tissues. The aim of this research was to determine and compare the pleiotropic effects of structurally different statins: atorvastatin, simvastatin and rosuvastatin
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The age-related association between serum creatinine and cardiorespiratory morbidity and mortality and fractures among adults with cerebral palsy Adv. Med. Sci. (IF 2.7) Pub Date : 2023-07-18
Purpose Serum creatinine may be an objective biomarker of salient health issues in adults with cerebral palsy (CP). The objective was to assess the age-related association between serum creatinine with 3-year risk of cardiorespiratory morbidity/mortality and fracture among adults with CP. Patients and methods This retrospective cohort study used medical records between Jan. 1, 2012 and Oct. 2, 2022
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Phenotypic and functional characterization of subpopulation of Imatinib resistant chronic myeloid leukemia cell line Adv. Med. Sci. (IF 2.7) Pub Date : 2023-07-06 Yalda Hekmatshoar, Aynur Karadag Gurel, Tulin Ozkan, Yalda Rahbar Saadat, Asli Koc, Arzu Zeynep Karabay, Sureyya Bozkurt, Asuman Sunguroglu
Purpose Chronic myeloid leukemia (CML) is a hematological malignancy characterized by the presence of BCR-ABL protein. Imatinib (IMA) is considered as the first line therapy in management of CML which particularly targets the BCR-ABL tyrosine kinase protein. However, emergence of resistance to IMA hinders its clinical efficiency. Hence, identifying novel targets for therapeutic approaches in CML treatment
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The development of DNA vaccines against SARS-CoV-2 Adv. Med. Sci. (IF 2.7) Pub Date : 2023-06-24 Kanwal Khalid, Chit Laa Poh
Background The COVID-19 pandemic exerted significant impacts on public health and global economy. Research efforts to develop vaccines at warp speed against SARS-CoV-2 led to novel mRNA, viral vectored, and inactivated vaccines being administered. The current COVID-19 vaccines incorporate the full S protein of the SARS-CoV-2 Wuhan strain but rapidly emerging variants of concern (VOCs) have led to significant
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Sertraline as a potential cancer therapeutic approach: Biological relevance of TCTP in breast cancer cell lines and tumors Adv. Med. Sci. (IF 2.7) Pub Date : 2023-06-26 Antonielle B. Baldissera, Marianna Boia-Ferreira, Alana B.C. Basílio, Jean Silva de Souza Resende, Mauro Antônio Alves Castro, Olga M. Chaim, Luiza Helena Gremski, Silvio S. Veiga, Andrea Senff-Ribeiro
Purpose This study aimed to evaluate the role of Translationally Controlled Tumor Protein (TCTP) in breast cancer (BC) and investigate the effects of sertraline, a serotonin selective reuptake inhibitor (SSRI), on BC cells. The objective was to assess the potential of sertraline as a therapeutic agent in BC treatment by examining its ability to inhibit TCTP expression and exert antitumor effects. Material
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Modified Bedside Index for severity in acute pancreatitis (BISAP) score validation in the national inpatient sample database Adv. Med. Sci. (IF 2.7) Pub Date : 2023-06-15 Do Han Kim, Frank J. Lukens, Donghyun Ko, Paul T. Kröner, Miguel Salazar, Massimo Raimondo, Pedro Palacios Argueta
Purpose The aim of this study was to build and validate modified score to be used in the healthcare cost and utilization project databases for further classification of acute pancreatitis (AP). Materials and methods The National Inpatient Sample database for the years 2016-2019 was queried for all primary adult discharge diagnoses of AP. An mBISAP score system was created utilizing the ICD-10CM codes
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Biomarkers of nitrosative stress in exhaled breath condensate and serum among patients with cystic fibrosis Adv. Med. Sci. (IF 2.7) Pub Date : 2023-05-31 Sabina Galiniak, Nataliya Rohovyk, Marta Rachel
Purpose The measurement of biomarkers in exhaled breath condensate (EBC) offers a non-invasive way to assess airway disease and can be easily done in a clinical setting among patients with cystic fibrosis (CF). The role of oxidative and nitrosative stress in the complex pathophysiology of CF is widely accepted and biomarkers of oxidative and nitrosative stress can be measured in the serum and EBC.
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Interleukin-33/sST2: Dynamic assessment in patients with acute coronary syndrome Adv. Med. Sci. (IF 2.7) Pub Date : 2023-05-20 Anna Witkowska, Mateusz Staciwa, Iwona Duraj, Ewelina Wozniak, Marlena Broncel, Paulina Gorzelak-Pabis
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Inhibition of airway smooth muscle contraction and proliferation by LIM kinase inhibitor, LIMKi3 Adv. Med. Sci. (IF 2.7) Pub Date : 2023-05-04 Ning Li, Yuanxiong Cheng, Shiyong Wang, Hua Liao, Shengming Liu
Purpose Current medical treatment for asthma aims to inhibit airway smooth muscle (ASM) contraction and proliferation, however, the efficacy of available treatment options is unsatisfactory. Therefore, we explored the effect of LIM domain kinase (LIMK) inhibitor - LIMKi3, on ASM to improve the understanding of ASM contraction and proliferation mechanisms, and to investigate new therapeutic targets
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Changes in tidal breathing biomarkers as indicators of treatment response in AECOPD patients in an acute care setting Adv. Med. Sci. (IF 2.7) Pub Date : 2023-05-03 Tess Nuñez Quiroga, Nadav Bachar, Wieland Voigt, Noy Danino, Inbal Shafran, Ronit Shtrichman, Gregory Shuster, Nina Lambrecht, Stephan Eisenmann
Purpose Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is a complication of COPD that typically necessitates intensified treatment and hospitalization. It is linked to higher morbidity, mortality and healthcare spending. Assessment of therapy response for AECOPD is difficult due to the variability of symptoms and limitations in current measures. Hence, there is a need for new
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Effect of hypoxia on HIF-1α and NOS3 expressions in CD34+ cells of JAK2V617F-positive myeloproliferative neoplasms Adv. Med. Sci. (IF 2.7) Pub Date : 2023-04-17 Can Veysel Şoroğlu, İldeniz Uslu-Bıçak, Selin Fulya Toprak, Akif Selim Yavuz, Selçuk Sözer
Purpose Myeloproliferative neoplasms (MPN) are a heterogeneous group of hematopoietic stem-cell diseases with excessive proliferation of one or more blood cell lines. In this study, we evaluated the effect of different oxygen concentrations on HIF-1α and NOS3 gene expression to determine the effect of the bone marrow microenvironment on JAK2V617F positive Philadelphia chromosome negative (Ph−) MPNs
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Vaccination with celecoxib-treated dendritic cells improved cellular immune responses in an animal breast cancer model Adv. Med. Sci. (IF 2.7) Pub Date : 2023-03-30 Raziyeh Zandvakili, Pedram Basirjafar, Javad Masoumi, Nahid Zainodini, Zahra Taghipour, Hossein Khorramdelazad, Soheila Yousefi, Tayyebeh Tavakoli, Sepehr Safdel, Mahsa Gheitasi, Fatemeh Ayoobi, Abdollah Jafarzadeh
Purpose Prostaglandin E2 (PGE2), a product of cyclooxygenase (COX) pathway of arachidonic acid, exerts inhibitory impacts on dendritic cell (DC) activity to repress anti-tumor immune responses. Therefore, targeting COX during DC vaccine generation may enhance DC-mediated antitumor responses. We aimed to investigate the impacts of DC vaccine treated with celecoxib (CXB), a selective COX2 inhibitor,
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Study on the effect of 5-aminolevulinic acid-mediated photodynamic therapy combined with cisplatin on human ovarian cancer OVCAR-3 cells Adv. Med. Sci. (IF 2.7) Pub Date : 2023-03-23 Haoxuan Lv, Yuping Suo, Qian Sun, Jingjing Fan, Qian Wang
Purpose This article explores the effect of 5-aminolevulinic acid (5-ALA)-mediated photodynamic therapy (PDT) combined with cisplatin (CDDP) on the apoptosis of human ovarian cancer cells and the mechanism of action of the combination therapy. Materials and methods Human ovarian cancer OVCAR-3 cells were cultured in vitro and divided into 5-ALA/PDT group, CDDP group and combined treatment group (5-ALA/PDT
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Pre-therapeutic molecular biomarkers of pathological response to neoadjuvant chemotherapy in gastric and esophago-gastric junction adenocarcinoma: A systematic review and meta-analysis Adv. Med. Sci. (IF 2.7) Pub Date : 2023-03-20 Kamil Nurczyk, Norbert Nowak, Rebecca Carlson, Tomasz Skoczylas, Grzegorz Wallner
Purpose Multimodal treatment is the standard of care in patients with locally advanced gastric cancer. Unfortunately, the response rate after neoadjuvant treatment remains limited. The ability to predict the response has a potential to improve patient outcomes by promoting a more individualized approach. We sought to describe the current state of research in pre-treatment molecular biomarkers of response