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NSUN6 regulates NM23-H1 expression in a m5C manner to affect epithelial-mesenchymal transition in lung cancer. Med. Princ. Pract. (IF 3.2) Pub Date : 2023-11-29 Zhansheng Lu,Bo Liu,Demiao Kong,Xiaojiang Zhou,Dengke Pei,Di Liu
PURPOSE The expression and regulatory mechanism of NSUN6 in lung cancer are still unclear. Our study explored whether NSUN6 mediates progression of lung cancer by affecting NM23-H1 expression in an m5C-dependent manner. METHODS qRT-PCR, CCK-8, colony formation, transwell and western blot analysis were employed to probe the impact of NSUN6 on lung cancer cell proliferation, migration and epithelial-mesenchymal
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Mitochondrial Common Deletion Level in Adipose Tissue is Not Associated with Obesity but is Associated with a Structural Change in Triglycerides as Revealed by FTIR Spectroscopy. Med. Princ. Pract. (IF 3.2) Pub Date : 2023-11-28 Ayda Yılmaz,Nurten Bahtiyar,Ayça Doğan Mollaoğlu,Kagan Zengin,Halit Eren Taskin,Ayla Karimova,Onur Baykara,Turgut Ulutin,Ilhan Onaran
OBJECTIVE Several studies have shown that the mitochondrial metabolism may be disrupted if the rate of the specific 4977 bp deletion of mitochondrial DNA (mtDNA) reaches a threshold. This study aims to investigate the possible associations between the mtDNA4977 deletion load and obesity-related metabolic abnormalities in the adipose tissue. METHODS The study included thirty obese individuals, who underwent
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Inconsistency in the application of Glasgow Coma Scale in paediatric patients. Med. Princ. Pract. (IF 3.2) Pub Date : 2023-10-27 Maria Caruana,Sophie Noelle Hackenbruch,Victor Grech,Ruth Farrugia
OBJECTIVE The Glasgow Coma Scale (GCS) is widely used to objectively describe the extent of patients' impaired consciousness. However, there are known variations in scoring GCS both in adults and children which may impact patient management. The aim of this audit is to assess the application of GCS by medical and nursing staff in pediatric medical patients. SUBJECT AND METHODS An online questionnaire
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The Potential of Bacteriophage Therapy as an Alternative Treatment Approach for Antibiotic-Resistant Infections. Med. Princ. Pract. (IF 3.2) Pub Date : 2023-10-25 Nike Walter,Mohammadali Mirzaei,Li Deng,Christian Willy,Volker Alt,Markus Rupp
OBJECTIVE This study aimed to provide a comprehensive overview of the current state of the literature on the therapeutical application of bacteriophages. METHODS First, a bibliometric analysis was performed using the database Web of Science to determine annual number of publications and citations. Second, a systematic literature review was conducted on randomized-controlled trials (RCTs) of phage therapy
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Microbiology and Inflammation Biomarkers of Bacteremia in Children in a Teaching Hospital in Kuwait: An 8-Year Retrospective Study. Med. Princ. Pract. (IF 3.2) Pub Date : 2023-10-23 Khalifa Al Benwan,Dalal Al Banwan
OBJECTIVES To determine the bacterial profile and prevalence of antibiotic resistance patterns of bacteria causing bacteremia in febrile children and to compare inflammatory markers levels between children with and without bacteremia at Al-Amiri Hospital, Kuwait from 2015 to 2022. MATERIALS AND METHODS Isolates from all episodes of significant bacteremia (n= 96) during the study period were recorded
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Reference Values for 3-Meter Backward Walk Test among Apparently Healthy Adults. Med. Princ. Pract. (IF 3.2) Pub Date : 2023-10-18 Chidozie E Mbada,Aanuoluwapo D Afolabi,Augusta Akinkuoye,Taofik O Afolabi,Adekola B Ademoyegun,Faatihah Niyi-Odumosu,Francis Fatoye
OBJECTIVE The 3-meter backward walk (3MBW) test is an outcome performance measure to assess backward walking mobility, balance, and risk of fall risk. However, the lack of baseline values is a potential limitation for its use as a rehabilitation target value or predictor of outcomes. This study aimed at ascertaining a gender-and age-reference value of 3MBW and determining its correlation with socio-demographic
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Prevalence and quality of life among overweight and obese women with different severity and types of urinary incontinence. Med. Princ. Pract. (IF 3.2) Pub Date : 2023-10-17 Baydaa Alsannan,Jehad Alharmi,Fatima Alrahal,Shaikha Al Mansoor,Togas Tulandi
OBJECTIVE The purpose of our study was to examine the prevalence, quality of life, severity and different types of urinary incontinence in overweight and obese women using an internationally validated questionnaire form. METHODS We conducted a cross-sectional study of 1351 consecutive patients, who were recruited between June 2021 and May 2022. Validated survey was used to assess the frequency, amount
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Hepatocellular Carcinoma Subtyping and Prognostic Model Construction Based on Chemokine-Related Genes. Med. Princ. Pract. (IF 3.2) Pub Date : 2023-10-17 Xiaoan Zhan,Yangyang Huang,Qiusheng Guo
BACKGROUND Chemokines not only regulate immune cells but also play significant roles in development and treatment of tumors and patient prognoses. However, these effects have not been fully explained in hepatocellular carcinoma (HCC). MATERIALS AND METHODS We conducted a clustering analysis of chemokine-related genes. We then examined the differences in survival rates and analyzed immune levels using
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Prognostic Worth of Nrf2/BACH1/HO-1 Protein Expression in the Development of Breast Cancer. Med. Princ. Pract. (IF 3.2) Pub Date : 2023-10-12 Precious Barnes,Elvis Agbo,Jianjie Wang,Benjamin Amoani,Yeboah Kwaku Opoku,Perditer Okyere,Roland Osei Saahene
OBJECTIVES Nrf2/ BACH1/ HO-1 proteins have been implicated in the development and progression of tumors. However, their clinical relevance in breast cancer remains unclear and understudied. This study evaluated Nrf2/ BACH1/ HO-1 protein expression and its relationship with age, tumor grade, tumor stage and TNM, ER, PR, HER2 and histologic type. METHODS 114 female breast cancer and 30 non-cancerous
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Friends and Foes in Alzheimer's Disease. Med. Princ. Pract. (IF 3.2) Pub Date : 2023-10-03 Ernest K J Pauwels,Gerard J Boer
Alzheimer's disease (AD) is a disabling neurodegenerative disease. The prognosis is poor and currently there are no proven effective therapies. Most likely, the etiology is related to cerebral inflammatory processes that cause neuronal damage, resulting in dysfunction and apoptosis of nerve cells. Pathogens that evoke a neuroinflammatory response, collectively activate astrocytes and microglia, which
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High Incidence of Appendiceal Neoplasms in the Elderly: A Critical Concern for Non-Surgical Treatment. Med. Princ. Pract. (IF 3.2) Pub Date : 2023-10-01 Gizem Issin,Fatih Demir,Irem Guvendir Bakkaloglu,Diren Vuslat Cagatay,Hasan Aktug Simsek,Ismail Yilmaz,Ebru Zemheri
OBJECTIVE Appendiceal neoplasms (ANs) are rare tumors that are often discovered incidentally during histopathological examinations. The increasing incidence of ANs is a critical issue in the non-operative management of acute appendicitis. This study aims to document the temporal trends over a twelve-year period by analyzing the clinical presentation, imaging findings, and histopathological features
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Omalizumab Transitions in Severe Asthma: Factors Influencing Switching Decisions and Timing for Optimal Response. Med. Princ. Pract. (IF 3.2) Pub Date : 2023-09-27 Mona Al-Ahmad,Asmaa Ali,Ahmed Maher
OBJECTIVE To assess the effectiveness of switching from omalizumab to another biologic therapy for patients with severe asthma and evaluate factors that influenced the decision to switch and determined the optimal time for a good biologic response. SUBJECTS AND METHODS A retrospective study of severe asthma patients was conducted at Al-Rashed Allergy, a tertiary center in Kuwait. After meeting the
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Biomarker Phenotypes in Heart Failure with Preserved Ejection Fraction Using Hierarchical Clustering-A Pilot Study. Med. Princ. Pract. (IF 3.2) Pub Date : 2023-09-21 Valentina Mitic,Dijana Stojanovic,Marina Deljanin-Ilic,Dejan Petrovic,Aleksandra Ignjatovic,Jelena Milenkovic
OBJECTIVES We hypothesized the existence of distinct phenotype-based groups within the very heterogeneous population of patients of heart failure with preserved ejection fraction (HFpEF) and using an unsupervised hierarchical clustering applied to plasma concentration of various biomarkers. We sought to characterize them as "biomarker phenotypes" and to conclude differences in their overall characteristics
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Isolated Femoral or Tibial Component Revision in Total Knee Arthroplasty: A Systematic Review. Med. Princ. Pract. (IF 3.2) Pub Date : 2023-09-20 Marco Maestri,Francesco Castagnini,Federico Giardina,Giuseppe Tella,Enrico Tassinari,Francesco Traina
OBJECTIVE The purpose of this systematic review is to assess clinical and radiographic outcomes, complications rates, rates and reasons of re-revision of isolated femoral or tibial component revisions, comparing them with total knee revisions. METHODS A review of the published literature was performed using Medline, Embase and Cochrane libraries. The terms "isolate" and "revision" and "knee arthroplasty"
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Ocular Surface, Intraocular Pressure and Lens Condition in Bronchodilator and Steroid-Treated Patients with Chronic Pulmonary Disease. Med. Princ. Pract. (IF 3.2) Pub Date : 2023-09-19 Özge Aydın Güçlü,Ayna Sariyeva Ismayilov
OBJECTIVES The aim of this study was to investigate ocular surface, intraocular pressure and lens condition in bronchodilator- and steroid-treated chronic pulmonary disease patients. METHODS In this cross-sectional clinical study, 101 patients with chronic pulmonary disease were treated with an inhaler and/or nebulized therapy for bronchodilatation. The patients were evaluated in 2 groups namely chronic
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A real-world retrospective study to evaluate the reliability of cetuximab plus capecitabine versus capecitabine as maintenance therapy in patients with RAS and BRAF wild-type metastatic colorectal cancer. Med. Princ. Pract. (IF 3.2) Pub Date : 2023-09-19 Jun Li,Hang Zhang,Xuli Guo,Shaoting Dong,Yi Li,Weizhen Huang,Xia Yuan
BACKGROUND The optimal maintenance therapy for RAS and BRAF metastatic colorectal cancers (mCRC) remains unclear. It is critical to evaluate the reliability of the observation group (cetuximab-capecitabine) relative to the control (capecitabine) as a treatment to maintain. PATIENTS AND METHODS In this retrospective analysis, patients with RAS and BRAF mCRC admitted to the Department of Medical Oncology
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Impact of Serotonin Pathway Gene Polymorphisms and Serotonin Levels in Suicidal Behavior. Med. Princ. Pract. (IF 3.2) Pub Date : 2023-09-15 Sneha Sivaramakrishnan,Vettriselvi Venkatesan,Sampath Kumar Paranthaman,R Sathianathan,Swetha Raghavan,Priyadarshee Pradhan
OBJECTIVE Suicide is a significant public health issue and a major cause of death in all ages worldwide. Previous studies have shown the involvement of genetics in suicidal behaviour. This study aimed to assess the role of the genetic variants of the serotonin transporter genes (5HTTLPR, SLC6A4 intron 2) and receptor gene (5HTR2AT102C) in individuals who died of suicide. The study compares the serum
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The Effects and Outcomes of the COVID-19 Pandemic on Pregnant Women in Kuwait. Med. Princ. Pract. (IF 3.2) Pub Date : 2023-09-14 Zahraa Akbar,Eman Al Azmi,Eelaf Husain,Mariam Aldarweesh,Khaled AlMuzayen,Fatemah Alhadhoud,Jehad Al Harmi
OBJECTIVES This retrospective study reports the effects of COVID-19 among hospitalized pregnant women infected with COVID-19 and compares them to a control group. METHODS A multi-center retrospective cohort study, in which data of pregnant women with COVID-19, admitted to five different hospitals in Kuwait, were collected. Two groups were included, the first group were women with COVID-19 who were
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Bioinformatics Analysis and Screening of Potential Target Genes Related to the Lung Cancer Prognosis. Med. Princ. Pract. (IF 3.2) Pub Date : 2023-09-14 Ping Huang,Yinfang Gu,Longhua Guo,Xiaofang Zou,Lilan Yi,Guowu Wu
OBJECTIVE Several genes have been validated as molecular targets for gene therapy in lung cancer. We screened target genes that affect survival of patients with lung cancer. METHODS Data on gene expression in normal lung tissues/lung adenocarcinoma (LUAD) samples were acquired from Genotype-Tissue Expression (GTEx)/The Cancer Genome Atlas (TCGA) databases and merged to expand the sample size, followed
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Thrombin Decrease in Thrombin Generation after Heparin Administration in a Homozygous Type II Heparin Binding Site Antithrombin-Deficient Pregnant Woman. Med. Princ. Pract. (IF 3.2) Pub Date : 2023-09-13 Ivana Malikova,Martina Husakova,Jana Bilkova,Radka Brzezkova,Tomas Kvasnicka
OBJECTIVES There is a major problem in providing prophylactic treatment in antithrombin (AT)-deficient pregnant women with a homozygous mutation of the heparin binding site (HBS) and AT level of 17 %. The aim of the study was to determine the effectiveness of heparin by monitoring changes in thrombin generation (TG) in vitro so that pregnant women are not exposed to stress in vivo. METHODS We used
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Chemical and Biological Characterization of Mycobacterium Tuberculosis-Specific ESAT6-Like Proteins and their Potentials in the Prevention of Tuberculosis and Asthma. Med. Princ. Pract. (IF 3.2) Pub Date : 2023-09-13 Abu Salim Mustafa
Early Secreted Antigenic Target 6 kDa (ESAT6) is a potent immunogenic protein secreted by the bacteria causing tuberculosis, i.e., Mycobacterium tuberculosis. Another highly immunogenic culture filtrate protein whose gene is linked to ESAT6/ESXA is known as CFP10/ESXB. Because of their high immunogenicity and specificity to M. tuberculosis, these proteins have been proposed as a vaccine to prevent
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In Vitro Investigation of Platelet Dysfunction Induced by Osmotic Pressure Variations. Med. Princ. Pract. (IF 3.2) Pub Date : 2023-09-13 Despoina Pantazi,Athina Stratou,Evangelia Dounousi,Anastasios Petrou,Alexandros D Tselepis
BACKGROUND Severe variations in osmotic pressure are significant contributors to critical patient morbidity and mortality and might also affect platelet volume. We aimed to investigate possible osmotic-induced changes in mean platelet volume (MPV) and their possible effects on platelet aggregation activity (PLAG). METHODS We induced experimental variations of serum osmolality in blood samples from
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Prevalence of Subclinical Cardiovascular Disease in Patients with Non-Alcoholic-Fatty Liver Disease: Analysis of the Paracelsus 10.000 Cohort Study. Med. Princ. Pract. (IF 3.2) Pub Date : 2023-09-07 Florian Koutny,Elmar Aigner,Christian Datz,Sophie Gensluckner,Andreas Maieron,Andrea Mega,Bernhard Iglseder,Patrick Langthaler,Vanessa Frey,Bernhard Paulweber,Eugen Trinka,Bernhard Wernly
BACKGROUND In patients with non-alcoholic fatty liver disease (NAFLD) cardiovascular diseases are more often the cause of death than the liver disease itself. However, the prevalence of atherosclerotic manifestations in individuals with NAFLD is still uncertain. This study aimed to explore the association between NAFLD and coronary artery calcification (CAC) in a Central European population. METHODS
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Increased Glucagon Immunoreactivity in a Rat Model of Diet-induced Obesity following Sleeve Gastrectomy. Med. Princ. Pract. (IF 3.2) Pub Date : 2023-08-25 Suleiman Al-Sabah,Mohammad H Jamal,Ghanim Al-Khaledi,Carol Dsouza,Fatemah AlOtaibi AlOtaibi,Waleed Al-Ali,Preethi Cherian,Irina Al-Khairi,Hamad Ali,Mohammad Abu-Farha,Jehad Abubaker,Fahd Al-Mulla
OBJECTIVE Bariatric surgery is currently the most effective treatment for obesity, and procedures such as Roux-en Y gastric bypass and sleeve gastrectomy (SG) also result in rapid improvements in insulin sensitivity and glucose tolerance. In addition, these procedures cause changes in the secretion of various gut-derived hormones. The role these hormones play in the mechanism of the beneficial effects
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Association between body composition and chronic low back pain in Korean adults aged over 50 years: The Korea National Health and Nutrition Examination Survey (KNHANES) 2010-2011. Med. Princ. Pract. (IF 3.2) Pub Date : 2023-08-07 Jae-Geum Shim,Kyoung-Ho Ryu,Eun-Ah Cho,Jin Hee Ahn,Jiyeon Park,Hyo-Won Lee,Suji Kang,So Young Han,Sung Hyun Lee
Background The relationship between overweight or obesity and low back pain (LBP) has previously been investigated. Several recent studies have focused on the relationship between other indicators of obesity, particularly indicators of fat and the risk of LBP. However, the results of body composition and LBP have been inconsistent. Methods All data for the present retrospective, cross-sectional study
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Evaluation of the CLL-IPI and IPS-E Prognostic Indices in a Young Middle Eastern Population with Chronic Lymphocytic Leukemia: A Retrospective Analysis at the Kuwait Cancer Control Center. Med. Princ. Pract. (IF 3.2) Pub Date : 2023-07-28 Salem H Alshemmari,Ahmad Alsarraf,Anita Kunhikrishnan,Ramesh Pandita
INTRODUCTION The Chronic Lymphocytic Leukemia International Prognostic Index (CLL-IPI) is a powerful prognostic tool validated in multiple Western populations. However, its utility in the young Middle Eastern population is unknown. METHODOLOGY We conducted a retrospective analysis of 152 unselected patients with chronic lymphocytic leukemia (CLL) diagnosed between 2008 and 2022 at the Kuwait Cancer
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Dimple of Venus Is Associated with the Increased Pelvic Incidence Angle and More Sagittally Oriented Facet Joint. Med. Princ. Pract. (IF 3.2) Pub Date : 2023-06-07 Kürşad Aytekin,Orhan Balta
OBJECTIVES The present study aims to investigate whether the dimple of Venus affects the anatomy of spinopelvic junction. SUBJECTS AND METHODS Inclusion criteria were having a lumbar MRI examination in the last 1 year, being older than 18 years of age and being able to radiologically evaluate the whole vertebral colon and pelvic girdle. Exclusion criteria were having congenital diseases of the pelvic
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Parkinson's Disease: A Tale of Many Players. Med. Princ. Pract. (IF 3.2) Pub Date : 2023-06-07 Ernest K J Pauwels,Gerard J Boer
In 2020, more than 9 million patients suffering from Parkinson's disease (PD) were reported worldwide, and studies predict that the burden of this disease will grow substantially in industrial countries. In the last decade, there has been a better understanding of this neurodegenerative disorder, clinically characterized by motor disturbances, impaired balance, coordination, memory difficulties, and
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COVID-19 Oral Sequelae: Persistent Gustatory and Saliva Secretory Dysfunctions after Recovery from COVID-19. Med. Princ. Pract. (IF 3.2) Pub Date : 2023-06-03 Hironori Tsuchiya
Diverse manifestations have been recognized to last for a long time in patients infected with SARS-CoV-2. However, understanding of oral sequelae after recovery from COVID-19 is relatively poor compared to that of oral symptoms in the acute phase of COVID-19 and other COVID-19 sequelae. The aim of the present study was to characterize persistent gustatory and saliva secretory dysfunctions and to speculate
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The Role of Intermittent Fasting and Dieting on Cognition in Adult Population: A Systematic Review of the Randomized Controlled Trials. Med. Princ. Pract. (IF 3.2) Pub Date : 2023-06-01 Helen Senderovich,Othman Farahneh,Sarah Waicus
OBJECTIVE A healthy diet is a modifiable risk factor that may impact cognition. A unique type of diet may include intermittent fasting (IF), an eating pattern in which individuals go extended periods with little or no meal intake, intervening with periods of normal food intake. IF has multiple health benefits including maintenance of blood glucose levels, reduction of insulin levels, depletion or reduction
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Efficacy and Safety of Actinium-225 Prostate-Specific Membrane Antigen Radioligand Therapy in Metastatic Prostate Cancer: A Systematic Review and Metanalysis. Med. Princ. Pract. (IF 3.2) Pub Date : 2023-05-29 Girish Kumar Parida,Raj Abhisek Panda,Komal Bishnoi,Kanhaiyalal Agrawal
BACKGROUND Actinium-225 (Ac-225) labelled PSMA RLT has been tested recently in metastatic castration-resistant prostate cancer (mCRPC), with encouraging results. Ac-225, being an alpha emitter, is expected to have higher efficacy and fewer side effects compared to the beta-emitters such as Lutetium-177. We have performed a meta-analysis to assess the therapeutic responses, survival effects, and significant
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The Impact of SARS-CoV-2 Infection in Unvaccinated Multiple Sclerosis Patients on Disease-Modifying Therapies. Med. Princ. Pract. (IF 3.2) Pub Date : 2023-05-03 Suhail Al-Shammri,Geeti Chadha,Arpita Chattopadhyay,Suhail Doi
OBJECTIVE Disease-modifying therapies (DMTs) in multiple sclerosis (MS) may affect the course and outcome of COVID-19, but withholding them could permit disease activity. This study aimed to understand the course of COVID-19 in unvaccinated patients with MS on disease-modifying therapies. SUBJECTS AND METHODS This descriptive study examined the course of COVID-19 among infected patients with MS followed
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Professor Olav Thulesius Med. Princ. Pract. (IF 3.2) Pub Date : 2023-04-20 Jasbir S. Juggi, Abdullatif Al-Bader
Med Princ Pract
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Response to Letter on “The Death of Pyotr Ilyich Tchaikovsky: The Result of Treatment with Arsenic?” Med. Princ. Pract. (IF 3.2) Pub Date : 2023-04-20 Ernest K.J. Pauwels
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Diagnostic and Prognostic Performance of Serum Albumin and Cholinesterase in Patients with Sepsis and Septic Shock Med. Princ. Pract. (IF 3.2) Pub Date : 2023-04-17 Tobias Schupp, Kathrin Weidner, Jonas Rusnak, Schanas Jawhar, Jan Forner, Floriana Dulatahu, Lea Marie Brück, Ursula Hoffmann, Thomas Bertsch, Julian Müller, Maximilian Kittel, Ibrahim Akin, Michael Behnes
Background: Despite improved risk stratification tools and identification of novel biomarkers, sepsis-related mortality has not significantly improved during the past years. Objective: This study investigates the diagnostic and prognostic role of the serum albumin and cholinesterase (ChE) in patients with sepsis and septic shock. Methods: Consecutive patients with sepsis and septic shock from 2019
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Antibiotic Sensitivity of Group B Streptococcus from Pregnant Mothers and its Association with Resistance Genes Med. Princ. Pract. (IF 3.2) Pub Date : 2023-04-06 Niluka Dilrukshi, Jananie Kottahachchi, Thushari Dissanayake, Neluka Fernando
Objective This study assessed the antibiotic susceptibility and characterized antibiotic resistance genes of GBS isolates from selected tertiary care hospitals in Western province, Sri Lanka Methods A descriptive cross-sectional study was carried to determine antibiotic sensitivity of GBS among 175 pregnant women of >35 weeks of gestation attending antenatal clinics in four teaching hospitals. Low
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The Death of Pyotr Ilyich Tchaikovsky: The Result of Treatment with Arsenic? Med. Princ. Pract. (IF 3.2) Pub Date : 2023-03-28 Ben Dijkmans, Peter de Leeuw
No abstract applicable. Med Princ Pract
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Sex-related bleeding risk in acute coronary syndrome patients receiving dual antiplatelet therapy with aspirin and a P2Y12 inhibitor. Med. Princ. Pract. (IF 3.2) Pub Date : 2023-03-22 Monique E. ten Haaf, Robert-Jan van Geuns, Marc M.J.M. van der Linden, Pieter C. Smits, Arie G. de Vries, Pieter A. Doevendans, Yolande Appelman, Eric Boersma
Aims To study sex differences in major bleeding in relation to dual antiplatelet therapy (DAPT) after percutaneous coronary intervention (PCI) for acute coronary syndrome (ACS). Methods and results The Collective Cardiology Research registry was designed to evaluate the application and outcomes of DAPT after ACS/PCI in the Rijnmond region in the Netherlands. Overall, 1172 women (median age 67.5 years)
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The New Coronavirus Pandemic and the Trend of Breast Cancer Diagnosis According to Age Group: Total and Interrupted Time Series Study Med. Princ. Pract. (IF 3.2) Pub Date : 2023-03-16
Objective: There is a lack of studies evaluating the COVID-19 pandemic effect on breast cancer detection according to age group. This study aimed to assess the pandemic impact on the trend of mammograms, breast biopsies, and breast cancer stage at diagnosis according to age group. Methods: This was an ecological time series study by inflection point regression model. We used data from women aged between
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Double Crown-retained Removable Prostheses Supported by Implants or Teeth and Implants, a Long-term Clinical Retrospective Evaluation. Med. Princ. Pract. (IF 3.2) Pub Date : 2023-02-03 Gregor Georg Zafiropoulos, Moosa Abuzayeda, Colin Alexander Murray, Mirza Rustum Baig
Objectives: The objective of this retrospective clinical study was to investigate the survival rates and complications of implant (I) or tooth-implant (TI) retained prostheses and abutments (teeth, implants) over a mean observation period of 11.26 years. The study also aimed to analyze the differences and complication rates between implant retained double crown removable dental prostheses (I-DC-RDPs)
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Double Crown-retained Removable Prostheses Supported by Implants or Teeth and Implants, a Long-term Clinical Retrospective Evaluation. Med. Princ. Pract. (IF 3.2) Pub Date : 2023-02-03
Objectives: The objective of this retrospective clinical study was to investigate the survival rates and complications of implant (I) or tooth-implant (TI) retained prostheses and abutments (teeth, implants) over a mean observation period of 11.26 years. The study also aimed to analyze the differences and complication rates between implant retained double crown removable dental prostheses (I-DC-RDPs)
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Experience of subcutaneous levetiracetam in palliative care Med. Princ. Pract. (IF 3.2) Pub Date : 2023-02-02 Mariana Gaviria-Carrillo, Laura Mora- Muñoz, Andrés Felipe Díaz-Forero, Juliana Vargas-Osorio, Viviana Torres-Ballesteros, Jhonatan Estrada, Alberto Vélez Van Meerbeke, Jesús Hernán Rodriguez
Background: Seizures are common in palliative care. Their control is essential in the management of these patients as it helps to reduce suffering at the end of life. Subcutaneous levetiracetam has been used off-license for seizure control in palliative care. Aim: Describe the experience of subcutaneous levetiracetam in two hospitals in Bogota, Colombia Methods: We conducted a retrospective review
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Experience of Subcutaneous Levetiracetam in Palliative Care Med. Princ. Pract. (IF 3.2) Pub Date : 2023-02-02
Background: Seizures are common in palliative care patients and its control is essential in the management of these patients as it helps to reduce suffering at the end of life. Subcutaneous levetiracetam has been used off-license for seizure control in palliative care. Objective: The objective of the study was to describe our experience with subcutaneous levetiracetam in two hospitals in Bogota, Colombia
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Assessment of Periodontal Status in Patients with Depression: A Cross Sectional Study Med. Princ. Pract. (IF 3.2) Pub Date : 2023-01-24 Aparna Kaushik, Nishi Tanwar, Shikha Tewari, Rajinder Kumar Sharma, Purushottam Jangid
Objective: Depression leads to behavioral and systemic changes making individuals more susceptible to inflammatory diseases. This study was conducted to assess the periodontal status of patients with clinically diagnosed mild and moderate depression. Subjects and Methods: This cross-sectional study included 135 participants. Test group 1 (n=45) consisted of patients clinically diagnosed with mild depression
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Assessment of Periodontal Status in Patients with Depression: A Cross-Sectional Study Med. Princ. Pract. (IF 3.2) Pub Date : 2023-01-24
Objective: Depression leads to behavioral and systemic changes making individuals more susceptible to inflammatory diseases. This study was conducted to assess the periodontal status of patients with clinically diagnosed mild and moderate depression. Subjects and Methods: This cross-sectional study included 135 participants. Test group 1 (n = 45) consisted of patients clinically diagnosed with mild
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Subjective and Objective Assessment of Chewing Performance in Older Adults with Different Dental Occlusion Med. Princ. Pract. (IF 3.2) Pub Date : 2023-01-20
Objectives: Satisfactory masticatory function is a significant indicator of improved oral health related quality of life in older adults, either with or artificial teeth. The purpose of this study was to examine masticatory performance of older adults with different prostho-dontic reconstructions and occlusion, as well as to compare subjective and objective as-sessment of chewing performance. Material
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Subjective and Objective Assessment of Chewing Performance in Older Adults with Different Dental Occlusion Med. Princ. Pract. (IF 3.2) Pub Date : 2023-01-20
Objectives: Satisfactory masticatory function is a significant indicator of improved oral health-related quality of life in older adults, either with or without artificial teeth. The purpose of this study was to examine masticatory performance of older adults with different prosthodontic reconstructions and occlusion, as well as to compare subjective and objective assessment of chewing performance
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Effect of Chemotherapy in Stage II-IV Large Cell Lung Carcinoma and Construction of its Predictive Nomograms: A SEER Analysis Med. Princ. Pract. (IF 3.2) Pub Date : 2023-01-18 Guoyan Hu, Yane Liu, Xinwei Li, Mengdi Jin, Xiangyu Liu, Qiong Yu
Objectives: Large cell lung carcinoma (LCLC) is generally poorly differentiated with a poor prognosis. This study aimed to explore the impact of chemotherapy on the prognosis of patients with stage Ⅱ-Ⅳ LCLC and to construct nomograms to predict overall survival (OS) and cancer-specific survival (CSS). Methods: Propensity score matching (PSM) analysis was used to balance the effects of baseline characteristics
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Effect of Chemotherapy in Stage II-IV Large Cell Lung Carcinoma and Construction of its Predictive Nomograms: A SEER Analysis Med. Princ. Pract. (IF 3.2) Pub Date : 2023-01-18
Objectives: Large cell lung carcinoma (LCLC) is generally poorly differentiated with a poor prognosis. This study aimed to explore the impact of chemotherapy on the prognosis of patients with stage Ⅱ-Ⅳ LCLC and to construct nomograms to predict overall survival (OS) and cancer-specific survival (CSS). Methods: Propensity score matching (PSM) analysis was used to balance the effects of baseline characteristics
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Association of socioeconomic status and oral cancer mortality in Brazil: temporal trends and spatial distribution Med. Princ. Pract. (IF 3.2) Pub Date : 2023-01-16 Débora dos Santos Tavares, Priscila Lima dos Santos, Márcio Bezerra Santos, Natanael Eric Batista Pereira, Deane Cristina da Rocha Rodrigues de Oliveira
The objective of this observational study was to evaluate the relationship between the oral cancer mortality rate and socioeconomic indicators throughout the Brazilian territory, between 2010 and 2019. The variables used in this study were oral cancer mortality rate from the Mortality Information System (SIM), population data from the Brazilian Institute of Geography and Statistics (IBGE), to calculate
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Association of Socioeconomic Status and Oral Cancer Mortality in Brazil: Temporal Trends and Spatial Distribution Med. Princ. Pract. (IF 3.2) Pub Date : 2023-01-16
Objective: The objective of this observational study was to evaluate the relationship between the oral cancer mortality rate and socioeconomic indicators throughout the Brazilian territory, between 2010 and 2019. Method: The variables used in this study were oral cancer mortality rates from the Mortality Information System (SIM) and population data from the Brazilian Institute of Geography and Statistics
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Reply to: “Qualitative Evaluation of α-Synuclein: A Critical Step in Unravelling the Complexities of Autism Spectrum Disorder” Med. Princ. Pract. (IF 3.2) Pub Date : 2023-01-10 Sarah H. Al-Mazidi, Laila Y. Al-Ayadhi
Med Princ Pract
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Reply to: “Qualitative Evaluation of α-Synuclein: A Critical Step in Unravelling the Complexities of Autism Spectrum Disorder” Med. Princ. Pract. (IF 3.2) Pub Date : 2023-01-10
Med Princ Pract
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List of Reviewers Vol. 31, 2022 Med. Princ. Pract. (IF 3.2) Pub Date : 2023-01-04
Med Princ Pract 2022;31:596
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Contents Vol. 31, 2022 Med. Princ. Pract. (IF 3.2) Pub Date : 2023-01-04
Med Princ Pract 2022;31:I–VI
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List of Reviewers Vol. 31, 2022 Med. Princ. Pract. (IF 3.2) Pub Date : 2023-01-04
Med Princ Pract 2022;31:596
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Contents Vol. 31, 2022 Med. Princ. Pract. (IF 3.2) Pub Date : 2023-01-04
Med Princ Pract 2022;31:I–VI
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The Association between Helicobacter pylori and Colorectal Neoplasia Med. Princ. Pract. (IF 3.2) Pub Date : 2022-12-29 Sarah Wernly, Georg Semmler, Maria Flamm, Richard Rezar, Elmar Aigner, Christian Datz, Bernhard Wernly
Objectives: Both Helicobacter pylori (H. pylori) and colorectal neoplasia (CRN) are frequent entities in gastroenterology. Epidemiological data suggest an association between H. pylori positivity (H. pylori +) and CRN, whereas pathophysiologic considerations substantiate a possible causal relationship. However, the relationship between CRN and H. pylori+ may also be mediated by shared risk factors
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The Association between Helicobacter pylori and Colorectal Neoplasia Med. Princ. Pract. (IF 3.2) Pub Date : 2022-12-29
Objectives: Helicobacter pylori (H. pylori) and colorectal neoplasia (CRN) are frequent entities. Epidemiological data suggest an association between H. pylori positivity (H. pylori +) and CRN, whereas pathophysiologic considerations substantiate a possible causal relationship. However, the relationship between CRN and H. pylori + may also be mediated by shared risk factors. Therefore, the aim of this
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Tei Index Complements Conventional Echocardiographic Parameters in Diagnostic Workup of Suspected Takotsubo Syndrome Med. Princ. Pract. (IF 3.2) Pub Date : 2022-12-26 Moritz Mirna, Fabian Vogl, Lukas Schmutzler, Richard Rezar, Elke Boxhammer, Albert Topf, Uta C. Hoppe, Michael Lichtenauer
Background: Tei index (TI) is a combined myocardial performance index for overall cardiac function, the sensitivity of which seems to be better than that of systolic and diastolic parameters alone. Evidence for TI in the context of Takotsubo syndrome (TTS) is currently limited, which is why we chose to investigate this parameter in affected patients. Subjects and Methods: Patients with TTS (n = 51)