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Communicating the Value of Influenza Vaccines to Patients: Translating Vaccine Effectiveness to Acceptance. Ann. Intern. Med. (IF 39.2) Pub Date : 2023-11-28 Mark W Tenforde,Fatimah S Dawood,Sascha R Ellington,Lisa A Grohskopf,Brendan Flannery,Shikha Garg,Carrie Reed
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Blood Pressure Effect of Traffic-Related Air Pollution : A Crossover Trial of In-Vehicle Filtration. Ann. Intern. Med. (IF 39.2) Pub Date : 2023-11-28 Michael T Young,Karen Jansen,Kristen E Cosselman,Timothy R Gould,James A Stewart,Timothy Larson,Coralynn Sack,Sverre Vedal,Adam A Szpiro,Joel D Kaufman
BACKGROUND Ambient air pollution, including traffic-related air pollution (TRAP), increases cardiovascular disease risk, possibly through vascular alterations. Limited information exists about in-vehicle TRAP exposure and vascular changes. OBJECTIVE To determine via particle filtration the effect of on-roadway TRAP exposure on blood pressure and retinal vasculature. DESIGN Randomized crossover trial
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Annals Graphic Medicine - Roots: Understanding the Role of Trauma-Informed Care. Ann. Intern. Med. (IF 39.2) Pub Date : 2023-11-28 Rachel Litchman
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Thyroidectomy for Euthyroid Patients With Hashimoto Disease and Persisting Symptoms. Ann. Intern. Med. (IF 39.2) Pub Date : 2023-11-28 Geir Hoff,Tomm Bernklev,Lene Johnsen,Laurens Reitsma,Dirk Sina,Andromeda Lauzike,Charlotte Gibbs,Eivind Carlsen,Tone Hoel Lende,Jon Kristian Narvestad,Rasmus Kildahl,Roald Omdal,Jan Terje Kvaløy,Håvard Søiland
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Two-Week Direct-Acting Antiviral Prophylaxis for Kidney Transplantation From Donors With Hepatitis C Viremia to Recipients Without Hepatitis C Viremia: A Small Uncontrolled Trial. Ann. Intern. Med. (IF 39.2) Pub Date : 2023-11-28 Niraj M Desai,Sherry G Leung,Jennifer D Motter,Dorry L Segev,Daniel Warren,Christine M Durand
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U.S. State Medical Boards' Antiracism Education Requirements for Physicians. Ann. Intern. Med. (IF 39.2) Pub Date : 2023-11-21 Max Jordan Nguemeni Tiako,Autumn Nobles,Muzzammil Muhammad,Marcella Nunez-Smith,Michael Barnett
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Building the Beloved (Health) Community: Antiracism, Diversity, and Primary Care. Ann. Intern. Med. (IF 39.2) Pub Date : 2023-11-21 Tonya Fancher,Olivia Campa
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Cardiovascular Health of Middle-Aged U.S. Adults by Income Level, 1999 to March 2020 : A Serial Cross-Sectional Study. Ann. Intern. Med. (IF 39.2) Pub Date : 2023-11-21 Michael Liu,Rahul Aggarwal,Zhaonian Zheng,Robert W Yeh,Dhruv S Kazi,Karen E Joynt Maddox,Rishi K Wadhera
BACKGROUND Although cardiovascular mortality has increased among middle-aged U.S. adults since 2011, how the burden of cardiovascular risk factors has changed for this population by income level over the past 2 decades is unknown. OBJECTIVE To evaluate trends in the prevalence, treatment, and control of cardiovascular risk factors among low-income and higher-income middle-aged adults and how social
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SARS-CoV-2 Virologic Rebound With Nirmatrelvir-Ritonavir Therapy : An Observational Study. Ann. Intern. Med. (IF 39.2) Pub Date : 2023-11-14 Gregory E Edelstein,Julie Boucau,Rockib Uddin,Caitlin Marino,May Y Liew,Mamadou Barry,Manish C Choudhary,Rebecca F Gilbert,Zahra Reynolds,Yijia Li,Dessie Tien,Shruti Sagar,Tammy D Vyas,Yumeko Kawano,Jeffrey A Sparks,Sarah P Hammond,Zachary Wallace,Jatin M Vyas,Amy K Barczak,Jacob E Lemieux,Jonathan Z Li,Mark J Siedner
BACKGROUND Data are conflicting regarding an association between treatment of acute COVID-19 with nirmatrelvir-ritonavir (N-R) and virologic rebound (VR). OBJECTIVE To compare the frequency of VR in patients with and without N-R treatment for acute COVID-19. DESIGN Observational cohort study. SETTING Multicenter health care system in Boston, Massachusetts. PARTICIPANTS Ambulatory adults with acute
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Rebound of COVID-19 With Nirmatrelvir-Ritonavir Antiviral Therapy. Ann. Intern. Med. (IF 39.2) Pub Date : 2023-11-14 Myron S Cohen,Elizabeth R Brown
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Annals Graphic Medicine - Principles of Medicine: Five Razors and a Dictum. Ann. Intern. Med. (IF 39.2) Pub Date : 2023-11-14 Zachary G Jacobs
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Impact of Clinical Demands on the Educational Mission in Hospital Medicine at 17 Academic Medical Centers : A Qualitative Analysis. Ann. Intern. Med. (IF 39.2) Pub Date : 2023-11-14 Vishruti Patel,Angela Keniston,Lauren McBeth,Sagarika Arogyaswamy,Catherine Callister,Khooshbu Dayton,Neelam Mistry,Sarah Mann,Marisha Burden
BACKGROUND Clinical growth is outpacing the growth of traditional educational opportunities at academic medical centers (AMCs). OBJECTIVE To understand the impact of clinical growth on the educational mission for academic hospitalists. DESIGN Qualitative study using semistructured interviews that were analyzed using a mixed inductive and deductive method at the semantic level. SETTING Large AMCs across
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Efficacy of Acupuncture for Chronic Spontaneous Urticaria : A Randomized Controlled Trial. Ann. Intern. Med. (IF 39.2) Pub Date : 2023-11-14 Hui Zheng,Xian-Jun Xiao,Yun-Zhou Shi,Lei-Xiao Zhang,Wei Cao,Qian-Hua Zheng,Feng Zhong,Ping-Sheng Hao,Ying Huang,Ming-Ling Chen,Wei Zhang,Si-Yuan Zhou,Yan-Jun Wang,Chuan Wang,Li Zhou,Xiao-Qin Chen,Zuo-Qin Yang,Zi-Hao Zou,Ling Zhao,Fan-Rong Liang,Ying Li
BACKGROUND The effectiveness of acupuncture for patients with chronic spontaneous urticaria (CSU), reported in a few small-scale studies, is not convincing. OBJECTIVE To investigate whether acupuncture leads to better effects on CSU than sham acupuncture or waitlist control. DESIGN A multicenter, randomized, sham-controlled trial. (Chinese Clinical Trial Registry: ChiCTR1900022994). SETTING Three teaching
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Annals On Call - Malaria in the United States. Ann. Intern. Med. (IF 39.2) Pub Date : 2023-11-07 Robert M Centor,Davidson H Hamer,Ralph Huits
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Conversations About Obesity and Weight: Good News We Can Use. Ann. Intern. Med. (IF 39.2) Pub Date : 2023-11-07 Christina C Wee,John E Cornell
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In low-risk penicillin allergies, direct oral challenge was noninferior to skin testing followed by oral challenge. Ann. Intern. Med. (IF 39.2) Pub Date : 2023-11-07 KoKo Aung,Thwe Htay
Copaescu AM, Vogrin S, James F, et al. Efficacy of a clinical decision rule to enable direct oral challenge in patients with low-risk penicillin allergy: the PALACE randomized clinical trial. JAMA Intern Med. 2023;183:944-952. 37459086.
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Personal Actions to Create a Culture of Inclusion: Navigating Difficult Conversations With Medical Colleagues. Ann. Intern. Med. (IF 39.2) Pub Date : 2023-11-07 Melanie S Sulistio,Christine L Chen,Ijeoma Eleazu,Sarah Godfrey,Reeni A Abraham,Lorrel E B Toft
Microaggressions between members of a team occur often in medicine, even despite good intentions. Such situations call for difficult conversations that restore inclusivity, diversity, and a healthy work culture. These conversations are often hard because of the unique background, experiences, and biases of each person. In medicine, skillful navigation of these interactions is paramount as it influences
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Accurate Measurements of Gastric Emptying and Gastrointestinal Symptoms in the Evaluation of Glucagon-like Peptide-1 Receptor Agonists. Ann. Intern. Med. (IF 39.2) Pub Date : 2023-11-07 Ryan J Jalleh,Karen L Jones,Michael Nauck,Michael Horowitz
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Colonoscopy-Ascertained Prevalence of Advanced Neoplasia According to Fecal Hemoglobin Concentration in a Large Cohort of Fecal Immunochemical Test-Negative Screening Participants. Ann. Intern. Med. (IF 39.2) Pub Date : 2023-11-07 Tobias Niedermaier,Thomas Heisser,Rafael Cardoso,Michael Hoffmeister,Hermann Brenner
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Effects of Remote Patient Monitoring Use on Care Outcomes Among Medicare Patients With Hypertension : An Observational Study. Ann. Intern. Med. (IF 39.2) Pub Date : 2023-11-07 Mitchell Tang,Carter H Nakamoto,Ariel D Stern,Jose R Zubizarreta,Felippe O Marcondes,Lori Uscher-Pines,Lee H Schwamm,Ateev Mehrotra
BACKGROUND Remote patient monitoring (RPM) is a promising tool for improving chronic disease management. Use of RPM for hypertension monitoring is growing rapidly, raising concerns about increased spending. However, the effects of RPM are still unclear. OBJECTIVE To estimate RPM's effect on hypertension care and spending. DESIGN Matched observational study emulating a longitudinal, cluster randomized
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In ischemic LV dysfunction, adding PCI to medical therapy did not reduce a composite of death or aborted sudden death. Ann. Intern. Med. (IF 39.2) Pub Date : 2023-11-07 Richard G Bach
Perera D, Morgan HP, Ryan M, et al; REVIVED-BCIS2 Investigators. Arrhythmia and death following percutaneous revascularization in ischemic left ventricular dysfunction: prespecified analyses from the REVIVED-BCIS2 trial. Circulation. 2023;148:862-871. 37555345.
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Relationship Between Clinician Language and the Success of Behavioral Weight Loss Interventions : A Mixed-Methods Cohort Study. Ann. Intern. Med. (IF 39.2) Pub Date : 2023-11-07 Charlotte Albury,Helena Webb,Elizabeth Stokoe,Sue Ziebland,Constantinos Koshiaris,Joseph J Lee,Paul Aveyard
BACKGROUND International guidelines recommend that primary care clinicians recognize obesity and offer treatment opportunistically, but there is little evidence on how clinicians can discuss weight and offer treatment in ways that are well received and effective. OBJECTIVE To examine relationships between language used in the clinical visit and patient weight loss. DESIGN Mixed-methods cohort study
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In RA, use of systemic glucocorticoids ≥5 mg/d (prednisolone-equivalent) was linked to MACE at 8.7 y. Ann. Intern. Med. (IF 39.2) Pub Date : 2023-11-07 Ami Schattner
So H, Lam TO, Meng H, et al. Time and dose-dependent effect of systemic glucocorticoids on major adverse cardiovascular event in patients with rheumatoid arthritis: a population-based study. Ann Rheum Dis. 2023;82:1387-1393.37487608.
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The Mifepristone Litigation: Untangling the Implications of the Fifth Circuit's Decision for Abortion Access and the U.S. Food and Drug Administration. Ann. Intern. Med. (IF 39.2) Pub Date : 2023-11-07 Patricia J Zettler,Lewis A Grossman,Eli Y Adashi,I Glenn Cohen
In August 2023, a federal appeals court issued an opinion in Alliance for Hippocratic Medicine v FDA, a case wherein a group of antiabortion medical organizations and physicians have challenged U.S. Food and Drug Administration (FDA) approval and regulation of mifepristone. This opinion contained some good news for the FDA, drug makers, and patients: the appeals court declined to halt the marketing
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In adults with HIV and low-to-moderate CV risk, pitavastatin reduced MACE over a median 5.1 y. Ann. Intern. Med. (IF 39.2) Pub Date : 2023-11-07 Scott Selinger
Grinspoon SK, Fitch KV, Zanni MV, et al; REPRIEVE Investigators. Pitavastatin to prevent cardiovascular disease in HIV infection. N Engl J Med. 2023;389:687-699. 37486775.
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In CAD, P2Y12 inhibitor vs. aspirin monotherapy reduces a composite CV outcome without increasing major bleeding. Ann. Intern. Med. (IF 39.2) Pub Date : 2023-11-07 Manasi Tannu,L Kristin Newby
Gragnano F, Cao D, Pirondini L, et al; PANTHER Collaboration. P2Y12 inhibitor or aspirin monotherapy for secondary prevention of coronary events. J Am Coll Cardiol. 2023;82:89-105. 37407118.
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In severe, uncontrolled asthma, tezepelumab reduced exacerbations over 1 y regardless of type 2 inflammation level. Ann. Intern. Med. (IF 39.2) Pub Date : 2023-11-07 Rodolfo A Estrada,Diego J Maselli
Corren J, Menzies-Gow A, Chupp G, et al. Efficacy of tezepelumab in severe, uncontrolled asthma: pooled analysis of the PATHWAY and NAVIGATOR clinical trials. Am J Respir Crit Care Med. 2023;208:13-24. 37015033.
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Thiazides do not affect mortality but may reduce CV events vs. nondiuretic antihypertensive drugs at up to 5 y. Ann. Intern. Med. (IF 39.2) Pub Date : 2023-11-07 Anuj A Patel,David S Goldfarb
Reinhart M, Puil L, Salzwedel DM, et al. First-line diuretics versus other classes of antihypertensive drugs for hypertension. Cochrane Database Syst Rev. 2023;7:CD008161. 37439548.
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In healthy older adults, low-dose aspirin did not differ from placebo for ischemic stroke but increased intracranial bleeding. Ann. Intern. Med. (IF 39.2) Pub Date : 2023-11-07 Salvador Cruz-Flores
Cloud GC, Williamson JD, Thao LTP, et al. Low-dose aspirin and the risk of stroke and intracerebral bleeding in healthy older people: secondary analysis of a randomized clinical trial. JAMA Netw Open. 2023;6:e2325803. 37494038.
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In patients with type 2 diabetes or HF, SGLT2 inhibitors reduce gout-related outcomes. Ann. Intern. Med. (IF 39.2) Pub Date : 2023-11-07 Katarzyna Nabrdalik,Gregory Y H Lip
Banerjee M, Pal R, Maisnam I, et al. Serum uric acid lowering and effects of sodium-glucose cotransporter-2 inhibitors on gout: a meta-analysis and meta-regression of randomized controlled trials. Diabetes Obes Metab. 2023;25:2697-2703. 37334516.
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Population Genomic Screening for Three Common Hereditary Conditions. Ann. Intern. Med. (IF 39.2) Pub Date : 2023-11-01 Linda Battistuzzi,Cristina Oliani,Stefania Sciallero,Maria Grazia Tibiletti,Daniela Turchetti,Liliana Varesco
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Annals Consult Guys - Postoperative Troponin Elevation. Ann. Intern. Med. (IF 39.2) Pub Date : 2023-11-01 Howard H Weitz,Geno J Merli
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Hypotension-Avoidance Versus Hypertension-Avoidance Strategies in Noncardiac Surgery. Ann. Intern. Med. (IF 39.2) Pub Date : 2023-11-01 Takeshi Fujieda,Tomoharu Kurokawa,Tetsuya Tanimoto
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Hypotension-Avoidance Versus Hypertension-Avoidance Strategies in Noncardiac Surgery. Ann. Intern. Med. (IF 39.2) Pub Date : 2023-11-01 Maura Marcucci,Kumar Balasubramanian,P J Devereaux
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Population Genomic Screening for Three Common Hereditary Conditions. Ann. Intern. Med. (IF 39.2) Pub Date : 2023-11-01 Josh F Peterson,David L Veenstra,Marc S Williams,Jing Hao,Gregory F Guzauskas
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Prevalence of Pharmacologic and Nonpharmacologic Pain Management Therapies Among Adults With Chronic Pain-United States, 2020. Ann. Intern. Med. (IF 39.2) Pub Date : 2023-11-01 S Michaela Rikard,Andrea E Strahan,Kristine M Schmit,Gery P Guy
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Effectiveness of Nirmatrelvir-Ritonavir Against the Development of Post-COVID-19 Conditions Among U.S. Veterans : A Target Trial Emulation. Ann. Intern. Med. (IF 39.2) Pub Date : 2023-10-31 George N Ioannou,Kristin Berry,Nallakkandi Rajeevan,Yuli Li,Pradeep Mutalik,Lei Yan,David Bui,Francesca Cunningham,Denise M Hynes,Mazhgan Rowneki,Amy Bohnert,Edward J Boyko,Theodore J Iwashyna,Matthew L Maciejewski,Thomas F Osborne,Elizabeth M Viglianti,Mihaela Aslan,Grant D Huang,Kristina L Bajema
BACKGROUND COVID-19 has been linked to the development of many post-COVID-19 conditions (PCCs) after acute infection. Limited information is available on the effectiveness of oral antivirals used to treat acute COVID-19 in preventing the development of PCCs. OBJECTIVE To measure the effectiveness of outpatient treatment of COVID-19 with nirmatrelvir-ritonavir in preventing PCCs. DESIGN Retrospective
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Clinical Effectiveness of Cognitively Enhanced Tai Ji Quan Training on Global Cognition and Dual-Task Performance During Walking in Older Adults With Mild Cognitive Impairment or Self-Reported Memory Concerns : A Randomized Controlled Trial. Ann. Intern. Med. (IF 39.2) Pub Date : 2023-10-31 Fuzhong Li,Peter Harmer,Elizabeth Eckstrom,Kathleen Fitzgerald,Kerri Winters-Stone
BACKGROUND Mild cognitive impairment (MCI) negatively impacts cognition and dual-task abilities. A physical-cognitive integrated treatment approach could mitigate this risk for dementia. OBJECTIVE To compare the effectiveness of cognitively enhanced tai ji quan versus standard tai ji quan or stretching exercise in improving global cognition and reducing dual-task walking costs in older adults with
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Health as a Human Right: A Position Paper From the American College of Physicians. Ann. Intern. Med. (IF 39.2) Pub Date : 2023-10-31 Matthew DeCamp,Lois Snyder Sulmasy,
The relationship of health to rights or human rights is complex. Although many find no right of any kind to health or health care, and others view health care as a right or human right, the American College of Physicians (ACP) instead sees health as a human right. The College, in the ACP Ethics Manual, has long noted the interrelated nature of health and human rights. Health as a human right also has
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ACP and the Human Right to Health. Ann. Intern. Med. (IF 39.2) Pub Date : 2023-10-31 P Preston Reynolds
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Submitting Your Work to Annals: Author-Friendly Features. Ann. Intern. Med. (IF 39.2) Pub Date : 2023-10-31 Jill Jackson,Christina C Wee,Christine Laine
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Next Steps for Clinical Xenotransplantation in the United States. Ann. Intern. Med. (IF 39.2) Pub Date : 2023-10-31 Tamar Schiff,Brendan Parent,Ian Dittmer,Wayne J Hawthorne,Ivo Kwon,Muhammad M Mohiuddin,Chun-Gyu Park,Peter Stock,Richard N Pierson
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Effect of Complementary Interventions to Redesign Care on Teamwork and Quality for Hospitalized Medical Patients : A Pragmatic Controlled Trial. Ann. Intern. Med. (IF 39.2) Pub Date : 2023-10-31 Kevin J O'Leary,Julie K Johnson,Mark V Williams,Ronald Estrella,Krystal Hanrahan,Luci K Leykum,G Randy Smith,Jenna D Goldstein,Jane S Kim,Sara Thompson,Iva Terwilliger,Jing Song,Jungwha Lee,Milisa Manojlovich
BACKGROUND Multiple challenges impede interprofessional teamwork and the provision of high-quality care to hospitalized patients. OBJECTIVE To evaluate the effect of interventions to redesign hospital care delivery on teamwork and patient outcomes. DESIGN Pragmatic controlled trial. Hospitals selected 1 unit for implementation of interventions and a second to serve as a control. (ClinicalTrials.gov:
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Changes in Induced Medical and Procedural Abortion Rates in a Commercially Insured Population, 2018 to 2022 : An Interrupted Time-Series Analysis. Ann. Intern. Med. (IF 39.2) Pub Date : 2023-10-24 Catherine S Hwang,Aaron S Kesselheim,Ameet Sarpatwari,Krista F Huybrechts,Gregory Brill,Benjamin N Rome
BACKGROUND During the COVID-19 pandemic, access to in-person care was limited, and regulations requiring in-person dispensing of mifepristone for medical abortions were relaxed. The effect of the pandemic and accompanying regulatory changes on abortion use is unknown. OBJECTIVE To estimate changes in the incidence rate of induced medical and procedural abortions. DESIGN Serial cross-sectional study
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Beyond Titles: The Need to Reduce Prescribing Variation of Potentially Inappropriate Medications Among All Clinicians. Ann. Intern. Med. (IF 39.2) Pub Date : 2023-10-24 Michelle S Keller,Catherine A Sarkisian
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Enough Is Enough: On the Road to Eliminating "Sophie's Choice" for U.S. Prescription Drugs. Ann. Intern. Med. (IF 39.2) Pub Date : 2023-10-24 Darilyn V Moyer,Shari M Erickson
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Inappropriate Prescribing to Older Patients by Nurse Practitioners and Primary Care Physicians. Ann. Intern. Med. (IF 39.2) Pub Date : 2023-10-24 Johnny Huynh,Sahil A Alim,David C Chan,David M Studdert
BACKGROUND Many U.S. states have legislated to allow nurse practitioners (NPs) to independently prescribe drugs. Critics contend that these moves will adversely affect quality of care. OBJECTIVE To compare rates of inappropriate prescribing among NPs and primary care physicians. DESIGN Rates of inappropriate prescribing were calculated and compared for 23 669 NPs and 50 060 primary care physicians
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Abortion Trends Amid Restrictions in a Commercially Insured U.S. Population: An Opportunity for Internal Medicine Physicians. Ann. Intern. Med. (IF 39.2) Pub Date : 2023-10-24 Jennifer L Michener,Mindy Sobota
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Hospitalized While Incarcerated: Incarceration-Specific Care Practices. Ann. Intern. Med. (IF 39.2) Pub Date : 2023-10-24 Farah Acher Kaiksow,Brie A Williams,Lawrence A Haber
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Annals Graphic Medicine - Dr. Mom: ICD-10 Codes for Parents. Ann. Intern. Med. (IF 39.2) Pub Date : 2023-10-24 Grace E Farris
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Correction: Information About Provision of Abortion on U.S. Hospital Websites. Ann. Intern. Med. (IF 39.2) Pub Date : 2023-10-17
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Correction: Effects of Implementation of a Supervised Walking Program in Veterans Affairs Hospitals. Ann. Intern. Med. (IF 39.2) Pub Date : 2023-10-17
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Would You Screen This Patient for Cognitive Impairment? : Grand Rounds Discussion From Beth Israel Deaconess Medical Center. Ann. Intern. Med. (IF 39.2) Pub Date : 2023-10-10 Risa B Burns,Michael J Barry,Deborah Blacker,Zahir Kanjee
Dementia, according to the American Psychiatric Association's Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, is defined by a significant decline in 1 or more cognitive domains that interferes with a person's independence in daily activities. Mild cognitive impairment (MCI) differs from dementia in that the impairment is not sufficient to interfere with independence. For the purposes
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Implications of the Use of Artificial Intelligence Predictive Models in Health Care Settings : A Simulation Study. Ann. Intern. Med. (IF 39.2) Pub Date : 2023-10-10 Akhil Vaid,Ashwin Sawant,Mayte Suarez-Farinas,Juhee Lee,Sanjeev Kaul,Patricia Kovatch,Robert Freeman,Joy Jiang,Pushkala Jayaraman,Zahi Fayad,Edgar Argulian,Stamatios Lerakis,Alexander W Charney,Fei Wang,Matthew Levin,Benjamin Glicksberg,Jagat Narula,Ira Hofer,Karandeep Singh,Girish N Nadkarni
BACKGROUND Substantial effort has been directed toward demonstrating uses of predictive models in health care. However, implementation of these models into clinical practice may influence patient outcomes, which in turn are captured in electronic health record data. As a result, deployed models may affect the predictive ability of current and future models. OBJECTIVE To estimate changes in predictive
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Surveillance of Xylazine Use and Poisonings Is Needed-Without Blind Spots. Ann. Intern. Med. (IF 39.2) Pub Date : 2023-10-10 Joseph J Palamar,Bruce A Goldberger
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Risk for Congenital Anomalies in Children Conceived With Medically Assisted Fertility Treatment : A Population-Based Cohort Study. Ann. Intern. Med. (IF 39.2) Pub Date : 2023-10-10 Christos Venetis,Stephanie K Y Choi,Louisa Jorm,Xian Zhang,William Ledger,Kei Lui,Alys Havard,Michael Chapman,Robert J Norman,Georgina M Chambers
BACKGROUND More than 2 million children are conceived annually using assisted reproductive technologies (ARTs), with a similar number conceived using ovulation induction and intrauterine insemination (OI/IUI). Previous studies suggest that ART-conceived children are at increased risk for congenital anomalies (CAs). However, the role of underlying infertility in this risk remains unclear, and ART clinical
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Xylazine Adulteration of the Heroin-Fentanyl Drug Supply : A Narrative Review. Ann. Intern. Med. (IF 39.2) Pub Date : 2023-10-10 Joseph D'Orazio,Lewis Nelson,Jeanmarie Perrone,Rachel Wightman,Rachel Haroz
Xylazine is an animal sedative, approved by the U.S. Food and Drug Administration, that is commonly used in veterinary medicine and is not approved for human use. Since 2016, xylazine has consistently appeared in the illicitly manufactured fentanyl supply and has significantly increased in prevalence, likely due to its low cost, easy availability, and presumed synergistic psychoactive effect. Clinical