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Use of tryptic peptide MALDI mass spectrometry imaging to identify the spatial proteomic landscape of colorectal cancer liver metastases. Clin. Exp. Med. (IF 4.6) Pub Date : 2024-03-16
Abstract Colorectal cancer (CRC) is the second leading cause of cancer-related deaths worldwide. CRC liver metastases (CRLM) are often resistant to conventional treatments, with high rates of recurrence. Therefore, it is crucial to identify biomarkers for CRLM patients that predict cancer progression. This study utilised matrix-assisted laser desorption/ionisation mass spectrometry imaging (MALDI-MSI)
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Advances in epigenetic alterations of chronic lymphocytic leukemia: from pathogenesis to treatment Clin. Exp. Med. (IF 4.6) Pub Date : 2024-03-16 Xin Zhang, Hua Wang, Ya Zhang, Xin Wang
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Circulating Bone morphogenetic protein 9 (BMP9) as a new biomarker for noninvasive stratification of nonalcoholic fatty liver disease and metabolic syndrome Clin. Exp. Med. (IF 4.6) Pub Date : 2024-03-16 Yuchen Yang, Meihong Gu, Wei Wang, Shan Li, Jinlai Lu, Qinjuan Sun, Miao Hu, Lan Zhong
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Non-tumor-related prognostic factors for immunotherapy–chemotherapy or immunotherapy alone as first-line in advanced non-small cell lung cancer (NSCLC) Clin. Exp. Med. (IF 4.6) Pub Date : 2024-03-15 Ziwei Guo, Xing Wei, Chuanhao Tang, Jun Liang
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Whole-exome sequencing is feasible on a fresh-frozen skin sample of intravascular large B cell lymphoma Clin. Exp. Med. (IF 4.6) Pub Date : 2024-03-05 Filippo Bagnoli, Giuditta Pini, Bachisio Ziccheddu, Arturo Bonometti, Silvia Alberti-Violetti, Luigia Venegoni, Giuseppe Isimbaldi, Matteo Claudio Da Vià, Angela Ferrari, Luca Baldini, Antonino Neri, Francesco Onida, Niccolò Bolli, Emilio Berti
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RUNX transcription factors: biological functions and implications in cancer Clin. Exp. Med. (IF 4.6) Pub Date : 2024-03-02 Xinyi Chen, Lu Wang, Mu Yang, Weiheng Zhao, Jingyao Tu, Bo Liu, Xianglin Yuan
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Research progress on the multi-omics and survival status of circulating tumor cells Clin. Exp. Med. (IF 4.6) Pub Date : 2024-03-01 Qingming Xie, Shilei Liu, Sai Zhang, Liqiu Liao, Zhi Xiao, Shouman Wang, Pengfei Zhang
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Sex-specific differences in ICOS+ T helper cell differentiation in systemic lupus erythematosus patients with low disease activity Clin. Exp. Med. (IF 4.6) Pub Date : 2024-03-01 Lisa Wu, Florian Kälble, Hanns-Martin Lorenz, Martin Zeier, Matthias Schaier, Andrea Steinborn
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Lymphoma relapse 1 year or later after immunochemotherapy in DLBCL patients: clinical features and outcome Clin. Exp. Med. (IF 4.6) Pub Date : 2024-03-01
Abstract Despite great advances in treatment, 30–40% of patients with DLBCL undergo relapses. Patients with a relapse within 1 year or beyond have a distinct outcome. Few clinical characteristics and survival data in the Chinese population have been published. We aimed to define the incidence and clinical features of DLBCL patients with very early relapse after front-line immunochemotherapy who may
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Therapeutic potential of mesenchymal stem cell-derived exosomes for regenerative medicine applications Clin. Exp. Med. (IF 4.6) Pub Date : 2024-03-01
Abstract Mesenchymal stem cell-derived exosomes have emerged as a promising cell-free therapy for tissue engineering. Compared to intact stem cells, exosomes have advantages like low immunogenicity and ability to carry regenerative cargo. This review examined the potential of exosomes to treat defects in skin, bone and cartilage. In preclinical models, exosomes improved wound healing, stimulated bone
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Elevated CD169 expressing monocyte/macrophage promotes systemic inflammation and disease progression in cirrhosis Clin. Exp. Med. (IF 4.6) Pub Date : 2024-02-28 Lichen Xu, Chunhong Huang, Xiaoping Zheng, Hainv Gao, Sainan Zhang, Mengfei Zhu, Xiahong Dai, Gang Wang, Jie Wang, Haolu Chen, Haihong Zhu, Zhi Chen
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Development and evaluation of nomograms and risk stratification systems to predict the overall survival and cancer-specific survival of patients with hepatocellular carcinoma Clin. Exp. Med. (IF 4.6) Pub Date : 2024-02-28 Xichun Kang, Xiling Liu, Yaoqi Li, Wenfang Yuan, Yi Xu, Huimin Yan
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Clinical and pathological findings of IgA nephropathy following SARS-CoV-2 infection Clin. Exp. Med. (IF 4.6) Pub Date : 2024-02-24 Hongfen Li, Zhao Li, Zhanfei Wu, Fanghao Wang, Yue Xing, Youxia Liu, Junya Jia, Tiekun Yan
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Causality between COVID-19 and multiple myeloma: a two-sample Mendelian randomization study and Bayesian co-localization Clin. Exp. Med. (IF 4.6) Pub Date : 2024-02-24 Shuaiyuan Wang, Na Zhao, Ting Luo, Songzi Kou, Miaomiao Sun, Kuisheng Chen
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Immunomodulatory effects of iTr35 cell subpopulation and its research progress Clin. Exp. Med. (IF 4.6) Pub Date : 2024-02-22 Chenxi Yang, Lingli Dong, Jixin Zhong
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Immune checkpoint inhibitors and risk of immune-mediated adverse events: a cohort study comparing extended versus standard interval administration Clin. Exp. Med. (IF 4.6) Pub Date : 2024-02-22 Amélia Lessard-Roy, Roxanne Marchand, Pierre Lemieux, Mélanie Masse, Alexandre Lacerte, Pierre-Hugues Carmichael, Danielle Laurin
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Intestinal microbiota regulates the gut-thyroid axis: the new dawn of improving Hashimoto thyroiditis Clin. Exp. Med. (IF 4.6) Pub Date : 2024-02-22 Xiaxin Zhu, Chi Zhang, Shuyan Feng, Ruonan He, Shuo Zhang
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Role of zinc in health and disease Clin. Exp. Med. (IF 4.6) Pub Date : 2024-02-17 Lucy I. Stiles, Kevin Ferrao, Kosha J. Mehta
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Treatment strategies in MDA5-positive clinically amyopathic dermatomyositis: a single-center retrospective analysis Clin. Exp. Med. (IF 4.6) Pub Date : 2024-02-17 Stefanie Hirsch, Gesa Helen Pöhler, Benjamin Seeliger, Antje Prasse, Torsten Witte, Thea Thiele
Melanoma differentiation-associated protein 5 (MDA5) antibody positive amyopathic dermatomyositis (DM) is a rare inflammatory disease. So far, there is no official treatment guideline in MDA5 amyopathic dermatomyositis, but early and aggressive immunosuppressive combination treatment can induce a stable remission. We retrospectively analyzed a cohort of eight patients (male n = 5) that were diagnosed
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Developing questions to assess and measure patients’ perceived survival benefit from adjuvant endocrine therapy in breast cancer: a mixed methods pilot study Clin. Exp. Med. (IF 4.6) Pub Date : 2024-02-14 Bernard Tawfik, Kendal Jacobson, Ursa Brown-Glaberman, Mikaela Kosich, M. Lee Van Horn, Jacklyn Nemunaitis, Zoneddy Dayao, V. Shane Pankratz, Andrew L. Sussman, Dolores D. Guest
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TET2 mutations contribute to adverse prognosis in acute myeloid leukemia (AML): results from a comprehensive analysis of 502 AML cases and the Beat AML public database Clin. Exp. Med. (IF 4.6) Pub Date : 2024-02-13 Xin’an Pan, Yingjun Chang, Guorui Ruan, Songhai Zhou, Hao Jiang, Qian Jiang, Xiaojun Huang, Xiao-Su Zhao
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Metabolomics and lipidomics signature in celiac disease: a narrative review Clin. Exp. Med. (IF 4.6) Pub Date : 2024-02-10 Mohammad Rostami-Nejad, Nastaran Asri, Sajjad Bakhtiari, Ensieh Khalkhal, Sepehr Maleki, Mostafa Rezaei-Tavirani, Somayeh Jahani-Sherafat, Kamran Rostami
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The clinical outcomes of haploidentical stem cell transplantation (haplo-HSCT) for patients with therapy-related myelodysplastic syndrome: comparable to de novo myelodysplastic syndrome Clin. Exp. Med. (IF 4.6) Pub Date : 2024-02-08 Feifei Tang, Yunqi Wang, Yu Wang, Jian Jin, Wei Han, Yuhong Chen, Chenhua Yan, Lanping Xu, Xiaohui Zhang, Xiaojun Huang
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Thermal ablation versus liver resection for hepatocellular carcinoma in patients with cirrhosis: a systematic review and meta-analysis of propensity-score matched studies Clin. Exp. Med. (IF 4.6) Pub Date : 2024-02-01 Qiuxia Wei, Shiyu Xiong, Wanrong Luo, Ming Liang, Baoming Luo
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Low SAA4 gene expression is associated with advanced HCC stage and a poor prognosis Clin. Exp. Med. (IF 4.6) Pub Date : 2024-02-01 Shilong Li, Dejun Kong, Weiqi Zhang, Yan Li, Hao Wang, Ruining Yang, Qian Sun, Zhenglu Wang, Zhongwei Zhang
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Stroke risk in rheumatoid arthritis patients: exploring connections and implications for patient care Clin. Exp. Med. (IF 4.6) Pub Date : 2024-01-31 Ola A. Al-Ewaidat, Moawiah M. Naffaa
Rheumatoid arthritis (RA) can independently increase the risk of stroke, affecting both young and adult RA patients. Recent attention has been drawn to the association between stroke and RA, supported by mounting evidence. Given that stroke is a significant and an urgent public health concern, this review aims to highlight the relationship between stroke and RA, covering mechanisms, underlying risk
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Decoding the regulatory landscape of lncRNAs as potential diagnostic and prognostic biomarkers for gastric and colorectal cancers Clin. Exp. Med. (IF 4.6) Pub Date : 2024-01-31 Arefeh Zabeti Touchaei, Sogand Vahidi, Ali Akbar Samadani
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SRRM2 may be a potential biomarker and immunotherapy target for multiple myeloma: a real-world study based on flow cytometry detection Clin. Exp. Med. (IF 4.6) Pub Date : 2024-01-30
Abstract Serine/arginine repetitive matrix 2 (SRRM2) has been implicated in tumorigenesis, cancer development, and drug resistance through aberrant splicing; however, its correlation with multiple myeloma (MM) has not been reported. We investigated the potential of SRRM2 as a biomarker and immunotherapeutic target in MM by examining its expression in MM cells using flow cytometry. Our study included
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The diagnostic role of the systemic inflammation index in patients with immunological diseases: a systematic review and meta-analysis Clin. Exp. Med. (IF 4.6) Pub Date : 2024-01-29
Abstract The identification of novel, easily measurable biomarkers of inflammation might enhance the diagnosis and management of immunological diseases (IDs). We conducted a systematic review and meta-analysis to investigate an emerging biomarker derived from the full blood count, the systemic inflammation index (SII), in patients with IDs and healthy controls. We searched Scopus, PubMed, and Web of
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Macrophages and angiogenesis in human lymphomas Clin. Exp. Med. (IF 4.6) Pub Date : 2024-01-29 Domenico Ribatti, Roberto Tamma, Tiziana Annese, Giuseppe Ingravallo, Giorgina Specchia
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Ascites fluid calprotectin level is highly accurate in diagnosing spontaneous bacterial peritonitis: a preliminary proof of concept prospective study Clin. Exp. Med. (IF 4.6) Pub Date : 2024-01-28 Wisam Sbeit, Basheer Maamoun, Subhi Azzam, Amir Shahin, Michal Carmiel-Haggai, Tawfik Khoury
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mRNA vaccine boosters and impaired immune system response in immune compromised individuals: a narrative review Clin. Exp. Med. (IF 4.6) Pub Date : 2024-01-27 Alberto Boretti
Over the last 24 months, there has been growing evidence of a correlation between mRNA COVID-19 vaccine boosters and increased prevalence of COVID-19 infection and other pathologies. Recent works have added possible causation to correlation. mRNA vaccine boosters may impair immune system response in immune compromised individuals. Multiple doses of the mRNA COVID-19 vaccines may result in much higher
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The association between hepatic viral infections and cancers: a cross-sectional study in the Taiwan adult population Clin. Exp. Med. (IF 4.6) Pub Date : 2024-01-27 Moreen Maliko, Fu-Hsiung Su, Abram Bunya Kamiza, Ming-Jang Su, Chih-Ching Yeh
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WNT/β-catenin regulatory roles on PD-(L)1 and immunotherapy responses Clin. Exp. Med. (IF 4.6) Pub Date : 2024-01-27 Keywan Mortezaee
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Vaccination protects against acute respiratory distress syndrome (ARDS) in hospitalized patients with COVID-19 Clin. Exp. Med. (IF 4.6) Pub Date : 2024-01-27 Julian Madrid, Prerana Agarwal, Katharina Müller-Peltzer, Marvin Askani, Leo Benning, Mischa Selig, Philipp Diehl, Johannes Kalbhenn, Georg Trummer, Stefan Utzolino, Tobias Wengenmayer, Hans-Jörg Busch, Daiana Stolz, Siegbert Rieg, Marcus Panning, Christopher L. Schlett, Fabian Bamberg, Esther Askani
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The relationship between peripheral T follicular helper cells and disease severity in systemic sclerosis Clin. Exp. Med. (IF 4.6) Pub Date : 2024-01-27 Melek Sahinoglu, Gokhan Sargin, Irfan Yavasoglu, Taskin Senturk
We aimed to investigate the association between follicular T helper cells (Tfh) and disease severity in systemic sclerosis (SSc), a chronic connective tissue disease characterized by progressive fibrosis. While Tfh cells have been extensively studied in other autoimmune diseases, their role in SSc remains poorly understood. A cohort of 50 SSc patients, diagnosed based on the ACR/EULAR 2013 classification
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Humoral and cellular immune response in patients of liver cirrhosis and immunocompetent recipient of ChAdOx1nCoV-19 Vaccine (Covishield) Clin. Exp. Med. (IF 4.6) Pub Date : 2024-01-27
Abstract Despite the effectiveness of COVID-19 vaccination in reducing the severity of the disease, the demand for booster is increasing in vulnerable populations like elderly and immunocompromised individuals especially with each new wave of COVID-19 in different countries. There is limited data on the sustained immunity against COVID-19 in patients with liver cirrhosis. The study was aimed to compare
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An inflammatory response-related gene signature can predict the prognosis and impact the immune infiltration of multiple myeloma Clin. Exp. Med. (IF 4.6) Pub Date : 2024-01-27 Qian Zhao, Feng Li, Jing Li, Yuan Xia, Jing Wang, Lijuan Chen
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FLI-1 is expressed in a wide variety of hematolymphoid neoplasms: a special concern in the differential diagnosis Clin. Exp. Med. (IF 4.6) Pub Date : 2024-01-27 Uiju Cho, Hee Jeong Cha, Hyun Jung Kim, Soo Kee Min, Hee Kyung Kim, Hye Ra Jung, Gyeongsin Park, Ji Eun Kim
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Early T-cell reconstitution predicts risk of EBV reactivation after allogeneic hematopoietic stem cell transplantation Clin. Exp. Med. (IF 4.6) Pub Date : 2024-01-27 Jingtao Huang, Zengkai Pan, Luxiang Wang, Zilu Zhang, Jiayu Huang, Chuanhe Jiang, Gang Cai, Tong Yin
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Systematic review of mortality and survival rates for APDS Clin. Exp. Med. (IF 4.6) Pub Date : 2024-01-27 Jennifer Hanson, Penelope E. Bonnen
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Global landscape of COVID-19 research: a visualization analysis of randomized clinical trials Clin. Exp. Med. (IF 4.6) Pub Date : 2024-01-22
Abstract The emergence of COVID-19 in 2019 has resulted in a significant global health crisis. Consequently, extensive research was published to understand and mitigate the disease. In particular, randomized controlled trials (RCTs) have been considered the benchmark for assessing the efficacy and safety of interventions. Hence, the present study strives to present a comprehensive overview of the global
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Humoral responses to wild type and ancient BA.1 SARS-CoV-2 variant after heterologous priming vaccination with ChAdOx1 nCoV-19 and BNT162b2 booster dose Clin. Exp. Med. (IF 4.6) Pub Date : 2024-01-20 Giuseppina Sanna, Alessandra Marongiu, Davide Firinu, Cristina Piras, Vanessa Palmas, Massimiliano Galdiero, Luigi Atzori, Paola Caria, Marcello Campagna, Andrea Perra, Giulia Costanzo, Ferdinando Coghe, Roberto Littera, Luchino Chessa, Aldo Manzin
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Idiopathic erythrocytosis: a germline disease? Clin. Exp. Med. (IF 4.6) Pub Date : 2024-01-20
Abstract Polycythemia Vera (PV) is typically caused by V617F or exon 12 JAK2 mutations. Little is known about Polycythemia cases where no JAK2 variants can be detected, and no other causes identified. This condition is defined as idiopathic erythrocytosis (IE). We evaluated clinical-laboratory parameters of a cohort of 56 IE patients and we determined their molecular profile at diagnosis with paired
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Herpes zoster after the third dose of SARS-CoV-2 mRNA-BNT162b2 vaccine in actively treated cancer patients: a prospective study Clin. Exp. Med. (IF 4.6) Pub Date : 2024-01-20 Fabrizio Nelli, Agnese Fabbri, Antonella Virtuoso, Diana Giannarelli, Eleonora Marrucci, Cristina Fiore, Julio Rodrigo Giron Berrios, Marta Schirripa, Carlo Signorelli, Mario Giovanni Chilelli, Francesca Primi, Valentina Panichi, Luciano Caterini, Stefania Farinelli, Maria Assunta Silvestri, Enzo Maria Ruggeri
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Assessment of bone turnover markers and DXA parameters to predict bone metastasis progression during zoledronate treatment: a single-center experience Clin. Exp. Med. (IF 4.6) Pub Date : 2024-01-19
Abstract Bone metastases (BM) are a serious cancer complication, potentially causing substantial morbidity. Among the clinical issues related to BM, there is the lack of specific tools for early diagnosis and prognosis. We explored whether combining bone turnover markers (BTM) with dual-energy X-ray absorptiometry (DXA) assessment could identify early BM progression and risk of skeletal-related events
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Recent nanotheranostic approaches in cancer research Clin. Exp. Med. (IF 4.6) Pub Date : 2024-01-19 Deepshikha Gupta, Priyanka Roy, Rishabh Sharma, Richa Kasana, Pragati Rathore, Tejendra Kumar Gupta
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Efficacy of omalizumab in adult patients with allergic bronchopulmonary aspergillosis: a multicentre study in China Clin. Exp. Med. (IF 4.6) Pub Date : 2024-01-19
Abstract Despite conventional glucocorticoid and antifungal therapy, acute exacerbation and hospitalization occur frequently in patients with allergic bronchopulmonary aspergillosis (ABPA). Whether omalizumab is an effective and safe treatment for adult patients with ABPA complicating asthma. Patients with ABPA complicating asthma who were treated with omalizumab from October 2019 to May 2023 were
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Elevated serum IL-2 and Th17/Treg imbalance are associated with gout Clin. Exp. Med. (IF 4.6) Pub Date : 2024-01-19 Xiaoyu Zi, Ronghui Su, Rui Su, Hui Wang, Baochen Li, Chong Gao, Xiaofeng Li, Caihong Wang
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Helios characterized circulating follicular helper T cells with enhanced functional phenotypes and was increased in patients with systemic lupus erythematosus Clin. Exp. Med. (IF 4.6) Pub Date : 2024-01-19 Xingyue Zeng, Xiayidan Alimu, Ayibaota Bahabayi, Zhonghui Zhang, Mohan Zheng, Zihang Yuan, Tianci Liu, Chen Liu
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Evaluation of NTRK expression and fusions in a large cohort of early-stage lung cancer Clin. Exp. Med. (IF 4.6) Pub Date : 2024-01-19 Anne Pernille Harlem Dyrbekk, Abdirashid Ali Warsame, Pål Suhrke, Marianne Odnakk Ludahl, Nermin Zecic, Joakim Oliu Moe, Marius Lund-Iversen, Odd Terje Brustugun
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Tumor-derived cell-free DNA and circulating tumor cells: partners or rivals in metastasis formation? Clin. Exp. Med. (IF 4.6) Pub Date : 2024-01-17
Abstract The origin of metastases is a topic that has sparked controversy. Despite recent advancements, metastatic disease continues to pose challenges. The first admitted model of how metastases develop revolves around cells breaking away from the primary tumor, known as circulating tumor cells (CTCs). These cells survive while circulating through the bloodstream and subsequently establish themselves
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Longitudinal study of human polyomaviruses viruria in kidney transplant recipients Clin. Exp. Med. (IF 4.6) Pub Date : 2024-01-17 Maria Dolci, Caterina Colico, Federico Ambrogi, Evaldo Favi, Lucia Signorini, Marta Perego, Edoardo Campioli, Kevin Kamau Maina, Pasquale Ferrante, Mariano Ferraresso, Serena Delbue
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The Systemic Immune-Inflammation Index (SII) and coronary artery lesions in Kawasaki disease Clin. Exp. Med. (IF 4.6) Pub Date : 2024-01-17 Tiantuo Huang, Qi Peng, Yiyue Zhang, Zaifu Zhu, Xiaochen Fan
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The demographic, laboratory and genetic factors associated with long Covid-19 syndrome: a case–control study Clin. Exp. Med. (IF 4.6) Pub Date : 2024-01-17 Ensiye Torki, Fahimeh Hoseininasab, Marjan Moradi, Ramin Sami, Mark J. M. Sullman, Hamed Fouladseresht
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Vaccine effectiveness of COVID-19 and rebound in the real world Clin. Exp. Med. (IF 4.6) Pub Date : 2023-11-16 Myung-Bae Park, Boram Sim
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Real-life diagnostic and therapeutic approach to CLL: a 2022 update from an expert panel in Tuscany Clin. Exp. Med. (IF 4.6) Pub Date : 2023-11-18 Claudia Baratè, Alessandro Sanna, Edoardo Benedetti, Monica Bocchia, Enrico Capochiani, Romano Danesi, Sabrina Moretti, Ubaldo Occhini, Simone Santini, Sara Galimberti, Alessandro Gozzetti
A panel of chronic lymphocytic leukemia (CLL) experts from Tuscany propose a real-life diagnostic and therapeutic approach CLL that considers the role of genomic and somatic prognostic factors in risk stratification and treatment decisions. Safety and efficacy of new agents has been demonstrated now not only in clinical trials but also in many real-world series. The BTK inhibitors, ibrutinib and acalabrutinib
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Clinical and imaging features of lymphomatosis cerebri: analysis of 8 cases and systematic review of the literature Clin. Exp. Med. (IF 4.6) Pub Date : 2023-11-18 Mengke Fan, Lu Zhao, Qingjiang Chen, Mingzhi Zhang, Xudong Zhang, Zhihao Yang, Suxiao Li, Yunfei Song
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EMT-induced immune evasion: connecting the dots from mechanisms to therapy Clin. Exp. Med. (IF 4.6) Pub Date : 2023-11-15 Sikiru O. Imodoye, Kamoru A. Adedokun
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Treatment outcomes of patients with classic and AIDS-related Kaposi Sarcoma: a single-center real-world experience Clin. Exp. Med. (IF 4.6) Pub Date : 2023-11-09 Bryan Valcarcel-Valdivia, Daniel Enriquez-Vera, Luis Enrique Piedra, Alexis Holguín, Gabriel De la Cruz Ku