-
Distinct electrophysiological properties of long-range GABAergic and glutamatergic neurons from the lateral amygdala to the auditory cortex of the mouse J. Phys. (IF 5.5) Pub Date : 2024-03-17 Alice Bertero, Alfonso junior Apicella
-
Muscle fibre typology affects whole-body metabolic rate during isolated muscle contractions and human locomotion J. Phys. (IF 5.5) Pub Date : 2024-03-17 Wannes Swinnen, Eline Lievens, Wouter Hoogkamer, Friedl De Groote, Wim Derave, Benedicte Vanwanseele
-
Renin the show: neuropilin-1's role in regulating juxtaglomerular cells J. Phys. (IF 5.5) Pub Date : 2024-03-17 Kyle H. Moore, Bryan K. Becker
In this issue of The Journal of Physiology, Shen et al. describe how neuropilin-1 mediates juxtaglomerular cell (JGC) fate and renin production (Shen et al., 2024). Renin is an enzyme that catalyses the conversion of angiotensinogen to angiotensin I, a key step in renin–angiotensin–aldosterone system's regulation of kidney sodium reabsorption, glomerular filtration rate (GFR) and blood pressure. Granules
-
Cyclic nucleotide-induced bidirectional long-term synaptic plasticity in Drosophila mushroom body J. Phys. (IF 5.5) Pub Date : 2024-03-15 Daichi Yamada, Andrew M. Davidson, Toshihide Hige
-
Assessment and modelling of the activation-dependent shift in optimal length of the human soleus muscle in vivo J. Phys. (IF 5.5) Pub Date : 2024-03-14 Sebastian Bohm, Arno Schroll, Falk Mersmann, Adamantios Arampatzis
-
A machine-learning tool to identify bistable states from calcium imaging data J. Phys. (IF 5.5) Pub Date : 2024-03-14 Aalok Varma, Sathvik Udupa, Mohini Sengupta, Prasanta Kumar Ghosh, Vatsala Thirumalai
-
Physical inactivity causes exercise resistance of fat metabolism: harbinger or culprit of disease? J. Phys. (IF 5.5) Pub Date : 2024-03-13 Edward F. Coyle
-
How preserved is right ventricular reserve in hypoxia? J. Phys. (IF 5.5) Pub Date : 2024-03-13 Stephen P. Wright, Tony G. Dawkins
The right ventricle (RV) utilizes oxygen to perform the work that drives blood through the pulmonary vasculature for gas exchange. The vasculature normally has high capacitance to receive pulsatile inflow and offers low resistance while conducting steady flow through the microcirculation. As such, modest RV systolic performance is required to develop pressure and eject stroke volume against low afterload
-
Circadian patterns of behaviour change during pregnancy in mice J. Phys. (IF 5.5) Pub Date : 2024-03-13 Georgia S. Clarke, Andrew D. Vincent, Sharon R. Ladyman, Kathryn L. Gatford, Amanda J. Page
-
FGF2 gene's antisense protein, NUDT6, plays a depressogenic role by promoting inflammation and suppressing neurogenesis without altering FGF2 signalling J. Phys. (IF 5.5) Pub Date : 2024-03-11 Burak Uzay, Aslıhan Bahadır-Varol, Fatma Özlem Hökelekli, Murat Yılmaz, Emre Cem Esen, Koray Başar, Yavuz Ayhan, Turgay Dalkara, Emine Eren-Koçak
-
PIEZO ion channels: force sensors of the interoceptive nervous system J. Phys. (IF 5.5) Pub Date : 2024-03-08 Yasmeen M. F. Hamed, Britya Ghosh, Kara L. Marshall
-
Ocular surface information seen from the somatosensory thalamus and cortex J. Phys. (IF 5.5) Pub Date : 2024-03-08 Enrique Velasco, Marta Zaforas, M. Carmen Acosta, Juana Gallar, Juan Aguilar
-
Reduction of left ventricular diastolic pressure as a key regulator of infarct coronary flow under mechanical left ventricular support J. Phys. (IF 5.5) Pub Date : 2024-03-08 Tomoki Sakata, Spyros A. Mavropoulos, Renata Mazurek, Francisco J. Romeo, Anjali J. Ravichandran, Jonas M. Marx, Taro Kariya, Kiyotake Ishikawa
-
Postsynaptic β1 spectrin maintains Na+ channels at the neuromuscular junction J. Phys. (IF 5.5) Pub Date : 2024-03-05 Ozlem Sert, Xiaoyun Ding, Chuansheng Zhang, Ruifa Mi, Ahmet Hoke, Matthew N. Rasband
-
The pathogenic roles of the p.R130S prestin variant in DFNB61 hearing loss J. Phys. (IF 5.5) Pub Date : 2024-03-03 Satoe Takahashi, Yingjie Zhou, Mary Ann Cheatham, Kazuaki Homma
-
Cathodal bilateral transcranial direct-current stimulation regulates selenium to confer neuroprotection after rat cerebral ischaemia–reperfusion injury J. Phys. (IF 5.5) Pub Date : 2024-03-03 Hui Wang, Wenlong Ma, Wenjie Hu, Xiaohua Li, Na Shen, Zhuo Li, Xiangyi Kong, Tao Lin, Jingchen Gao, Ting Zhu, Fengyuan Che, Juan Chen, Qi Wan
-
Reorganization of mitochondria–organelle interactions during postnatal development in skeletal muscle J. Phys. (IF 5.5) Pub Date : 2024-03-01 Yuho Kim, Hailey A. Parry, T. Bradley Willingham, Greg Alspaugh, Eric Lindberg, Christian A. Combs, Jay R. Knutson, Christopher K. E. Bleck, Brian Glancy
-
The Bayliss–Starling Prize Lecture: The developmental physiology of spinal cord and cortical nociceptive circuits J. Phys. (IF 5.5) Pub Date : 2024-03-01 Maria Fitzgerald
-
The role of CFTR in diabetes-induced pancreatic ductal dysfunction J. Phys. (IF 5.5) Pub Date : 2024-02-29 Oleg V. Gerasimenko, Julia V. Gerasimenko
The pancreas is a vital organ with dual functions, serving both exocrine and endocrine roles. The exocrine pancreas is responsible for the production and secretion of digestive enzymes and fluids by pancreatic acinar cells (PACs) followed by supplementation with bicarbonate (HCO3−) and delivery by the pancreatic duct to the duodenum, aiding food digestion (Petersen et al., 2021). The endocrine pancreas
-
Thermal physiology is a (wo)man's world! J. Phys. (IF 5.5) Pub Date : 2024-02-29 Davide Filingeri, Hannah Blount, Jade Ward
Women undergo unique anatomical, physiological and hormonal changes across their lifespan. For example, consider the impact of the menstrual cycle, pregnancy and menopause, all of which are accompanied by both short- and long-term effects on women's body morphology (e.g. changes in breast size, hip angle, muscle development) as well as on their body temperature regulation, heat tolerance and thermal
-
Effects of periodic breathing on sleep at high altitude: a randomized, placebo-controlled, crossover study using inspiratory CO2 J. Phys. (IF 5.5) Pub Date : 2024-02-26 Abubaker Ibrahim, Ambra Stefani, Matteo Cesari, Johanna Roche, Hannes Gatterer, Evi Holzknecht, Rachel Turner, Giovanni Vinetti, Michael Furian, Anna Heidbreder, Birgit Högl, Christoph Siebenmann
-
Right ventricular performance during acute hypoxic exercise J. Phys. (IF 5.5) Pub Date : 2024-02-26 Lindsay M. Forbes, Todd M. Bull, Tim Lahm, Tyler Sisson, Katie O'Gean, Justin S. Lawley, Kendall Hunter, Benjamin D. Levine, Andrew Lovering, Robert C. Roach, Andrew W. Subudhi, William K. Cornwell
-
Conserved mammalian muscle mechanics during eccentric contractions J. Phys. (IF 5.5) Pub Date : 2024-02-24 Roger W. P. Kissane, Graham N. Askew
-
Orexinergic neurons contribute to autonomic cardiovascular regulation for locomotor exercise J. Phys. (IF 5.5) Pub Date : 2024-02-21 Emi Narai, Yuki Yoshimura, Takaho Honaga, Hiroyuki Mizoguchi, Akihiro Yamanaka, Takeshi Y. Hiyama, Tatsuo Watanabe, Satoshi Koba
-
Neuropilin-1 regulates renin synthesis in juxtaglomerular cells J. Phys. (IF 5.5) Pub Date : 2024-02-21 Yunzhu Shen, Kenza Lotenberg, Jeremy Zaworski, Katharina A.-E. Broeker, Florence Vasseur, Liliane Louedec, Sandrine Placier, Perrine Frère, Marie-Christine Verpont, Pierre Galichon, David Buob, Juliette Hadchouel, Fabiola Terzi, Christos Chatziantoniou, Amélie Calmont
-
Vagotomy blunts cardiorespiratory responses to vagal afferent stimulation via pre- and postsynaptic effects in the nucleus tractus solitarii J. Phys. (IF 5.5) Pub Date : 2024-02-20 Gabrielle C. Hofmann, Procopio Gama de Barcellos Filho, Fateme Khodadadi, Daniela Ostrowski, David D. Kline, Eileen M. Hasser
-
In vivo treatment with calcilytic of CaSR knock-in mice ameliorates renal phenotype reversing downregulation of the vasopressin-AQP2 pathway J. Phys. (IF 5.5) Pub Date : 2024-02-17 Marianna Ranieri, Ines Angelini, Mariagrazia D'Agostino, Annarita Di Mise, Mariangela Centrone, Maria Venneri, Angela Ferrulli, Maria Mastrodonato, Grazia Tamma, Itsuro Endo, Seiji Fukumoto, Toshio Matsumoto, Giovanna Valenti
-
Role of CFTR in diabetes-induced pancreatic ductal fluid and HCO3− secretion J. Phys. (IF 5.5) Pub Date : 2024-02-22 Attila Ébert, Eleonóra Gál, Emese Tóth, Titanilla Szögi, Péter Hegyi, Viktória Venglovecz
-
Residual force depression is not related to positive muscle fascicle work during submaximal voluntary dorsiflexion contractions in humans J. Phys. (IF 5.5) Pub Date : 2024-02-21 Brent James Raiteri, Leon Lauret, Daniel Hahn
-
In vivo mitochondria-targeted protection against uterine artery vascular dysfunction and remodelling in rodent hypoxic pregnancy J. Phys. (IF 5.5) Pub Date : 2024-02-21 Zhongchao Wang, Emily J. Camm, Anna Maria Nuzzo, Ana-Mishel Spiroski, Katie L. Skeffington, Thomas J. Ashmore, Alessandro Rolfo, Tullia Todros, Angela Logan, Jin Ma, Michael P. Murphy, Youguo Niu, Dino A. Giussani
-
Myoglobin deficiency impairs maximal oxygen uptake and exercise performance: a lesson from Mb−/− mice J. Phys. (IF 5.5) Pub Date : 2024-02-20 Jerzy A. Zoladz, Marcin Grandys, Marta Smeda, Agnieszka Kij, Anna Kurpinska, Grzegorz Kwiatkowski, Janusz Karasinski, Ulrike Hendgen-Cotta, Stefan Chlopicki, Joanna Majerczak
-
Salt reabsorption in the renal distal convoluted tubule: past, present and future J. Phys. (IF 5.5) Pub Date : 2024-02-20 Søren Brandt Poulsen
Pre-urine is generated by filtration of blood in the glomerulus, whereafter it passes through a complex network of highly specialized tubule sections, which reabsorb and secrete compounds via channels and transporters to produce the final urine. These processes are precisely regulated by hormones, thus allowing the body to keep the right ion balance. Channel and transport activity in the tubules are
-
Evening but not morning aerobic training improves sympathetic activity and baroreflex sensitivity in elderly patients with treated hypertension J. Phys. (IF 5.5) Pub Date : 2024-02-20 Leandro C. Brito, Luan M. Azevêdo, Graziela Amaro-Vicente, Luis R. Costa, Natan D. da Silva Junior, John R. Halliwill, Maria U. P. B. Rondon, Cláudia L. M. Forjaz
-
Rodents’ visual gamma as a biomarker of pathological neural conditions J. Phys. (IF 5.5) Pub Date : 2024-02-19 Nicolò Meneghetti, Eleonora Vannini, Alberto Mazzoni
-
Interactions between calcium-induced arrhythmia triggers and the electrophysiological–anatomical substrate underlying the induction of atrial fibrillation J. Phys. (IF 5.5) Pub Date : 2024-02-19 Michael A. Colman, Marta Varela, Rob S. MacLeod, Jules C. Hancox, Oleg V. Aslanidi
-
Hormonal intrauterine devices and heat exchange during exercise J. Phys. (IF 5.5) Pub Date : 2024-02-17 Nathalie V. Kirby, Robert D. Meade, Brodie J. Richards, Sean R. Notley, Glen P. Kenny
-
Circulating noradrenaline leads to release of neuropeptide Y from cardiac sympathetic nerve terminals via activation of β-adrenergic receptors J. Phys. (IF 5.5) Pub Date : 2024-02-14 Valerie Y. H. van Weperen, Jonathan D. Hoang, Neil R. Jani, Artin Khaky, Neil Herring, Corey Smith, Marmar Vaseghi
-
Severe hypoxaemic hypercapnia compounds cerebral oxidative–nitrosative stress during extreme apnoea: Implications for cerebral bioenergetic function J. Phys. (IF 5.5) Pub Date : 2024-02-13 Damian M. Bailey, Anthony R. Bain, Ryan L. Hoiland, Otto F. Barak, Ivan Drvis, Benjamin S. Stacey, Angelo Iannetelli, Gareth W. Davison, Rasmus H. Dahl, Ronan M. G. Berg, David B. MacLeod, Zeljko Dujic, Philip N. Ainslie
-
Reduced plakoglobin increases the risk of sodium current defects and atrial conduction abnormalities in response to androgenic anabolic steroid abuse J. Phys. (IF 5.5) Pub Date : 2024-02-12 Laura C. Sommerfeld, Andrew P. Holmes, Ting Y. Yu, Christopher O'Shea, Deirdre M. Kavanagh, Jeremy M. Pike, Thomas Wright, Fahima Syeda, Areej Aljehani, Tania Kew, Victor R. Cardoso, S. Nashitha Kabir, Claire Hepburn, Priyanka R. Menon, Sophie Broadway-Stringer, Molly O'Reilly, Anika Witten, Lisa Fortmueller, Susanne Lutz, Alexandra Kulle, Georgios V. Gkoutos, Davor Pavlovic, Wiebke Arlt, Gareth G
-
Inhibition and potentiation of the exercise pressor reflex by pharmacological modulation of TRPC6 in male rats J. Phys. (IF 5.5) Pub Date : 2024-02-10 Guillaume P. Ducrocq, Laura Anselmi, Salvatore L. Stella, Steven W. Copp, Victor Ruiz-Velasco, Marc P. Kaufman
-
Personalized depth-specific neuromodulation of the human primary motor cortex via ultrasound J. Phys. (IF 5.5) Pub Date : 2024-02-15 Shancheng Bao, Hakjoo Kim, Nandan B. Shettigar, Yue Li, Yuming Lei
-
Cortical–brainstem circuitry attenuates physiological stress reactivity J. Phys. (IF 5.5) Pub Date : 2024-02-14 Sebastian A. Pace, Ema Lukinic, Tyler Wallace, Carlie McCartney, Brent Myers
-
Inspiratory and sigh breathing rhythms depend on distinct cellular signalling mechanisms in the preBötzinger complex J. Phys. (IF 5.5) Pub Date : 2024-02-14 Daniel S. Borrus, Marco K. Stettler, Cameron J. Grover, Eva J. Kalajian, Jeffrey Gu, Gregory D. Conradi Smith, Christopher A. Del Negro
-
Thermodynamic limitations on brain oxygen metabolism: physiological implications* J. Phys. (IF 5.5) Pub Date : 2024-02-13 Richard B. Buxton
-
Optogenetic confirmation of transverse-tubular membrane excitability in intact cardiac myocytes J. Phys. (IF 5.5) Pub Date : 2024-02-13 Marina Scardigli, Michal Pásek, Lorenzo Santini, Chiara Palandri, Emilia Conti, Claudia Crocini, Marina Campione, Leslie M. Loew, Antoine A. F. de Vries, Daniël A. Pijnappels, Francesco S. Pavone, Corrado Poggesi, Elisabetta Cerbai, Raffaele Coppini, Peter Kohl, Cecilia Ferrantini, Leonardo Sacconi
-
Role of paraoxonase 3 in regulating ENaC-mediated Na+ transport in the distal nephron J. Phys. (IF 5.5) Pub Date : 2024-02-12 Stephanie M. Mutchler, Sarah Christine M. Whelan, Allison Marciszyn, Jingxin Chen, Thomas R. Kleyman, Shujie Shi
-
Excitatory action of low frequency depolarizing GABA/glycine synaptic inputs is prevalent in prenatal spinal SOD1G93A motoneurons J. Phys. (IF 5.5) Pub Date : 2024-02-12 Hongmei Zhu, Urvashi Dalvi, William Cazenave, Daniel Cattaert, Pascal Branchereau
-
Human sodium current voltage-dependence at physiological temperature measured by coupling a patch-clamp experiment to a mathematical model J. Phys. (IF 5.5) Pub Date : 2024-02-12 Veronika O. Abrasheva, Sandaara G. Kovalenko, Mihail Slotvitsky, Serafima А. Romanova, Aleria A. Aitova, Sheida Frolova, Valeria Tsvelaya, Roman A. Syunyaev
-
Role of tissue biomechanics in the formation and function of myocardial trabeculae in zebrafish embryos J. Phys. (IF 5.5) Pub Date : 2024-02-12 Adriana Gaia Cairelli, Alex Gendernalik, Wei Xuan Chan, Phuc Nguyen, Julien Vermot, Juhyun Lee, David Bark, Choon Hwai Yap
-
Sympathetic transduction of cardiac sympathetic nerve activity in healthy, conscious sheep J. Phys. (IF 5.5) Pub Date : 2024-02-08 Dilsha Gimhani, Julia Shanks, Mridula Pachen, Joshua W-H Chang, Rohit Ramchandra
-
Blockage of aquaporin-3 peroxiporin activity by organogold compounds affects melanoma cell adhesion, proliferation and migration J. Phys. (IF 5.5) Pub Date : 2024-02-07 Inês V. da Silva, Catarina Pimpão, Inês Paccetti-Alves, Sophie R. Thomas, Andreia Barateiro, Angela Casini, Graça Soveral
-
What is the point of cerebral blood flow? J. Phys. (IF 5.5) Pub Date : 2024-02-07 Jay M. J. R. Carr
Teleological justification – that is, assigning function to phenomena as opposed to describing in purely mechanistic terms – is inescapable in Physiology, due to the explanatory power it brings. Think: the heart pumps blood in order to supply a situation-appropriate cardiac output and properly compensates when called upon. This teleological justification of cardiac function as serving cardiac output
-
Pre-intervention myocardial stress is a good predictor of aortic valvoluplasty outcome for fetal critical aortic stenosis and evolving HLHS J. Phys. (IF 5.5) Pub Date : 2024-02-07 Laura Green, Wei Xuan Chan, Indumita Prakash, Andreas Tulzer, Gerald Tulzer, Choon Hwai Yap
-
Does dopamine mediate the effects of exercise on cognition? J. Phys. (IF 5.5) Pub Date : 2024-02-06 Marc Roig, Jacopo Cristini
Dopamine is a neurotransmitter that plays an important role in a broad range of psychological and cognitive processes such as mood and emotional regulation, motivation, executive function, learning, memory, and motor control (Ko & Strafella, 2012). Alterations in the dopaminergic activity of the brain have been shown to contribute to age-related cognitive decline and to the pathogenesis of several
-
The effects of daily dose of intense exercise on cardiac responses and atrial fibrillation J. Phys. (IF 5.5) Pub Date : 2024-02-06 Renée A. Gorman, Simona Yakobov, Nazari Polidovitch, Ryan Debi, Victoria C. Sanfrancesco, David A. Hood, Robert Lakin, Peter H. Backx
-
Acylation stimulating protein/C3adesArg in the metabolic states: role of adipocyte dysfunction in obesity complications J. Phys. (IF 5.5) Pub Date : 2024-02-02 Reza Rezvani, Mohammad Reza Shadmand Foumani Moghadam, Katherine Cianflone
-
A revision of maximal oxygen consumption and exercise capacity at altitude 70 years after the first climb of Mount Everest J. Phys. (IF 5.5) Pub Date : 2024-02-01 Guido Ferretti, Giacomo Strapazzon
-
Genetic influences on motor learning and performance and superperforming mutants revealed by random mutational survey of the mouse genome J. Phys. (IF 5.5) Pub Date : 2024-02-01 Vikram Jakkamsetti, Qian Ma, Gustavo Angulo, William Scudder, Bruce Beutler, Juan M. Pascual
-
Dietary sodium alters aldosterone's effect on renal sodium transporter expression and distal convoluted tubule remodelling J. Phys. (IF 5.5) Pub Date : 2024-01-31 Stephanie M. Mutchler, Mahpara Hasan, Carolyn P. Murphy, Catherine J. Baty, Cary Boyd-Shiwarski, Annet Kirabo, Thomas R. Kleyman
-
Spontaneous slow wave oscillations in extracellular field potential recordings reflect the alternating dominance of excitation and inhibition J. Phys. (IF 5.5) Pub Date : 2024-01-31 Ying Zheng, Sungmin Kang, Joseph O'Neill, Ingo Bojak