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GEMIN4 Variants: Risk Profiling, Bioinformatics, and Dynamic Simulations Uncover Susceptibility to Bladder Carcinoma Arch. Med. Res. (IF 7.7) Pub Date : 2024-02-23 Abdallah S. Mohamed, Afrah F. Salama, Magdy A. Sabaa, Eman Toraih, Rami M. Elshazli
The relationship between GEMIN4 genetic variants and cancer, especially bladder carcinoma (BLCA), has been explored without conclusive results. This study aims to elucidate the link between GEMIN4 polymorphisms and BLCA susceptibility through genetic analyses, bioinformatics, and molecular dynamics (MD) simulations. A cohort of 249 participants (121 BLCA patients and 128 unrelated controls) was enrolled
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Global Prevalence and Severity of Retinopathy of Prematurity over the Last Four Decades (1985–2021): A Systematic Review and Meta-Analysis Arch. Med. Res. (IF 7.7) Pub Date : 2024-02-18 Heladia García, Miguel Angel Villasis-Keever, Georgina Zavala-Vargas, Juan Carlos Bravo-Ortiz, Ayari Pérez-Méndez, Alberto Escamilla-Núñez
Retinopathy of prematurity (ROP) is a vasoproliferative disease of the retina that occurs in premature infants. The prevalence of ROP reported so far is inconsistent. To conduct a systematic review to describe the trend of ROP prevalence between 1985 and 2021, and to determine the influence of countries’ economic conditions on ROP prevalence. We searched PubMed, Embase, and Google Scholar for studies
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Determinants of Vitamin D Status in Healthy Young Adults from Mexico City Arch. Med. Res. (IF 7.7) Pub Date : 2024-02-17 Alva Belen Morales-Villar, Jorge Maldonado-Hernández, Nelson Eduardo Álvarez-Licona, Mónica Ivette Piña-Aguero, Salvador Villalpando-Hernández, Ricardo Martín Robledo-Pérez, Ismael Díaz-Rangel, María de Lourdes Barbosa-Cortés, Benjamín-Armando Núñez-García
Vitamin D deficiency is a global health problem. The determinants of this deficiency have not been evaluated in developing countries such as Mexico. Thus, this study aimed to determine vitamin D intake and sun exposure and its relationship with plasma concentrations of 25-hydroxyvitamin D -25(OH)D- in young adults from Mexico City. One hundred fifty five urban adult subjects were enrolled during 2017
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Human Intestinal Defensin 5 Ameliorates the Sensitization of Colonic Cancer Cells to 5-Fluorouracil Arch. Med. Res. (IF 7.7) Pub Date : 2024-02-08 Anshul Panjeta, Khushpreet Kaur, Rinkle Sharma, Indu Verma, Simran Preet
The increasing dilemma of multidrug-resistant cancer cells in response to currently available chemotherapeutic drugs and their associated side effect(s), calls for the investigation of alternative anticancer advances and molecules. Therefore, the present study aimed to elucidate the combinatorial potential against colon cancer of human defensin 5 in combination with 5-fluorouracil (5-FU), and against
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CETP-derived Peptide Seq-1, the Key Component of HB-ATV-8 Vaccine Prevents Stress Responses, and Promotes Downregulation of Pro-Fibrotic Genes in Hepatocytes and Stellate Cells Arch. Med. Res. (IF 7.7) Pub Date : 2024-02-01 Sandra Calixto-Tlacomulco, Ismael Luna-Reyes, Blanca Delgado-Coello, Roxana Gutiérrez-Vidal, Juan Pablo Reyes-Grajeda, Jaime Mas-Oliva
The nasal vaccine HB-ATV-8 has emerged as a promising approach for NAFLD (non-alcoholic fatty liver disease) and atherosclerosis prevention. HB-ATV-8 contains peptide seq-1 derived from the carboxy-end of the Cholesteryl Ester Transfer Protein (CETP), shown to reduce liver fibrosis, inflammation, and atherosclerotic plaque formation in animal models. Beyond the fact that this vaccine induces B-cell
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De Novo Vitiligo Following Covid-19 Infection and Vaccination: A Door Open to Future Events? Arch. Med. Res. (IF 7.7) Pub Date : 2024-01-30 R, a, f, f, a, e, l, l, a, , M, o, r, m, i, l, e
Abstract not available
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Evaluating a Novel Newborn Screening Methodology: Combined Genetic and Biochemical Screenings Arch. Med. Res. (IF 7.7) Pub Date : 2024-01-30 Bin Yu, Yuqi Yang, Lingna Zhou, Qiuwei Wang
Analysis of four newborn screening modes using newborn genomic sequencing (nGS) and traditional biochemical screening (TBS). Prospective clinical study with a total of 1,012 newborn samples from retrospective TBS. Three independent groups performed the study under strict double-blind conditions according to the screening modes: independent biochemical (IBS), independent NeoSeq (INS), sequential (SS)
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Repositioning FDA-Approved Drug Against Chagas Disease and Cutaneous Leishmaniosis by Structure-Based Virtual Screening Arch. Med. Res. (IF 7.7) Pub Date : 2024-01-29 Alfredo Juarez-Saldivar, Rogelio Gómez-Escobedo, Gerardo Corral-Ruiz, Karla Fabiola Chacón-Vargas, Vanessa Horta-Montaño, Luvia Sanchez-Torres, Lenci k. Vazquez-Jimenez, Benjamín Nogueda-Torres, Gildardo Rivera
Chagas disease and cutaneous leishmaniasis, two parasitic diseases caused by () and (), respectively, have a major global impact. Current pharmacological treatments for these diseases are limited and can cause severe side effects; thus, there is a need for new antiprotozoal drugs. Using molecular docking, this work describes a structure-based virtual screening of an FDA-approved drug library against
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Intranasal Versus Intravenous Dexamethasone to Treat Hospitalized COVID-19 Patients: A Randomized Multicenter Clinical Trial Arch. Med. Res. (IF 7.7) Pub Date : 2024-01-29 Graciela Cárdenas, María Chávez-Canales, Ana María Espinosa, Antonio Jordán-Ríos, Daniel Anica Malagon, Manlio Fabio Márquez Murillo, Laura Victoria Torres Araujo, Ricardo Leopoldo Barajas Campos, Rosa María Wong-Chew, Luis Esteban Ramirez González, Karent Ibet Cresencio, Enrique García Velázquez, Mariana Rodriguez de la Cerda, Yoana Leyva, Joselin Hernández-Ruiz, María Luisa Hernández-Medel, Mireya
SARS-CoV2 induces flu-like symptoms that can rapidly progress to severe acute lung injury and even death. The virus also invades the central nervous system (CNS), causing neuroinflammation and death from central failure. Intravenous (IV) or oral dexamethasone (DXM) reduced 28 d mortality in patients who required supplemental oxygen compared to those who received conventional care alone. Through these
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Effect of Fibrate Treatment on Circulating Adipokine Levels: A Systematic Review and Meta-analysis of Randomized Clinical Trials Arch. Med. Res. (IF 7.7) Pub Date : 2024-01-24 Luis E. Simental-Mendía, Mario Simental-Mendía, Amirhossein Sahebkar, Stephen L. Atkin, Tannaz Jamialahmadi
Fibrates are widely used in the treatment of dyslipidemia and associated metabolic abnormalities; however, their effects on adipokines are unclear. Aim of the study. This meta-analysis of clinical trials aimed to evaluate the effect of fibrates on circulating adipokine levels. Only randomized controlled trials investigating the impact/effect of fibrate treatment on circulating adipokine levels were
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Traumatic Human Spinal Cord Injury: Are Single Treatments Enough to Solve the Problem? Arch. Med. Res. (IF 7.7) Pub Date : 2023-12-28 Israel Grijalva-Otero, Ernesto Doncel-Pérez
Traumatic spinal cord injury (SCI) results in partial or complete motor deficits, such as paraplegia, tetraplegia, and sphincter control, as well as sensory disturbances and autonomic dysregulation such as arterial hypotension, lack of sweating, and alterations in skin lability. All this has a strong psychological impact on the affected person and his/her family, as well as costs to healthcare institutions
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Expression of EPB41L2 in Cancer-Associated Fibroblasts: Prognostic Implications for Bladder Cancer and Response to Immunotherapy Arch. Med. Res. (IF 7.7) Pub Date : 2023-12-27 Tianqi Wang, Guixin Ding, Xiaoyu Wang, Yuanshan Cui, Xiaohong Ma, Jian Ma, Jitao Wu
Background Immunotherapy response in patients with bladder cancer (BLCA) treated with immune checkpoint inhibitors (ICIs) is variable. The accurate evaluation of immunotherapy efficacy may be facilitated by the tumor microenvironment (TME). Erythrocyte membrane protein band 4.1 like 2 (EPB41L2), a cytoskeletal protein with a regulatory role in the TME was intensively investigated to determine its biological
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Multidisciplinary Panel Consensus for the Management of Patients with Type 2 Diabetes: A Delphi Study Arch. Med. Res. (IF 7.7) Pub Date : 2023-12-22 Ana M. Cebrián-Cuenca, Oscar Moreno-Pérez, Raquel Campuzano-Ruiz, Maria Jose Soler, M. Dolores García de Lucas, Domingo Orozco-Beltrán
Aim To reach a multidisciplinary consensus on managing patients with type 2 diabetes among specialists in family medicine, cardiology, endocrinology, internal medicine, and nephrology. Methods A two-round Delphi study was conducted using a questionnaire with 68 positive/negative statements distributed in four thematic blocks on diabetes management: early diagnosis and prediabetes, referral criteria
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Spanish adaptation and validation of the ALS Depression Inventory-12 (ADI-12) in patients with Amyotrophic Lateral Sclerosis Arch. Med. Res. (IF 7.7) Pub Date : 2023-12-22 David Sancho-Cantus, Laura Cubero-Plazas, Jesús Privado, Eduardo Jesús Aguilar García-Iturrospe, Montserrat Cañabate Ros, Esther Navarro-Illana, José Enrique de la Rubia Ortí
Background Patients with Amyotrophic Lateral Sclerosis (ALS) have a higher prevalence of mood disorders, including depression, than the general population. Non-specific measurement instruments have been used to evaluate depression in these patients, which complicates accurate diagnosis. The ALS Depression Inventory (ADI-12) exclusively assesses depressive symptoms in patients with ALS. Aim To adapt
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Multimodal Prognostic Model for Predicting Chronic Coronary Artery Disease in Patients Without Obstructive Sleep Apnea Syndrome Arch. Med. Res. (IF 7.7) Pub Date : 2023-12-06 Yanan Xu, Jun Wang, Zhen Zhou, Yi Yang, Long Tang
Background Obstructive sleep apnea syndrome (OSAS), with metabolic disorders as a central feature, is closely correlated with coronary artery disease (CAD). Our goal was to develop a prediction nomogram that integrated multimodal data that could accurately predict the prognosis of patients with chronic coronary disease (CCD). Methods We evaluated 393 patients with CCD with a low-to-intermediate pretest
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Factor XII Deficiency in Mexico: High Prevalence in the General Population and Patients with Venous Thromboembolic Disease Arch. Med. Res. (IF 7.7) Pub Date : 2023-12-07 Víctor Manuel Dominguez-Reyes, Jesus Hernandez-Juarez, Rodrigo Arreola-Diaz, Karim Majluf-Cruz, Elba Reyes-Maldonado, José Antonio Alvarado-Moreno, Luis Antonio Moreno Ruiz, Abraham Majluf-Cruz
Introduction Thrombosis is one of the leading causes of morbidity and mortality worldwide. Venous thromboembolic disease (VTD) is considered a new epidemic. FXII deficiency is supposed to be a cause of thrombosis. To search for unknown causes of thrombosis in our population, our aim was to determine if FXII deficiency can be considered a risk factor for VTD. Methods Young adult Mexican patients with
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Controversies In Neuroendocrinology Arch. Med. Res. (IF 7.7) Pub Date : 2023-12-01 Philippe Chanson, Moises Mercado
Abstract not available
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Efficacy and Safety of Endoscopic Transsphenoidal Resection for Prolactinoma: A Retrospective Multicenter Case-series Arch. Med. Res. (IF 7.7) Pub Date : 2023-11-30 Ingrid Marijke Zandbergen, Kristin Michelle Huntoon, Timothy G. White, Leontine Erica Henriëtte Bakker, Marco Johanna Theodorus Verstegen, Luma Mudhafar Ghalib, Wouter Ralph van Furth, Iris Catharina Maria Pelsma, Amir R. Dehdashti, Nienke Ruurdje Biermasz, Daniel M. Prevedello
Background Endoscopic transsphenoidal surgery (ETSS) for prolactinoma is reserved for dopamine agonist (DA) resistance, intolerance, or apoplexy. High remission (overall 67%, microprolactinoma up to 90%), low recurrence (5–20%) rates highlighted that surgery might be first-line treatment. Aims To report on outcomes of ETSS in a cohort of prolactinomas. Methods Multicenter retrospective cohort of 137
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ABHD5-CPT1B: An Important Way of Regulating Placental Lipid Metabolism in Gestational Diabetes Mellitus Arch. Med. Res. (IF 7.7) Pub Date : 2023-12-01 Yuqi Yang, Yue Peng, Bin Yu, Huiyan Wang
Background and Aim Gestational diabetes mellitus (GDM) is one of the most common metabolic disorders in pregnancy, and a novel association of maternal lipid profile has been suggested to play an important role. However, the molecular mechanism is not clear. Methods Bio-analyzed combined with placental metabonomics and single-cell RNA-sequencing (scRNA-seq) successfully identified a potentially important
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Predictors of Response to Treatment with First-Generation Somatostatin Receptor Ligands in Patients with Acromegaly Arch. Med. Res. (IF 7.7) Pub Date : 2023-12-01 Montserrat Marques-Pamies, Joan Gil, Mireia Jordà, Manel Puig-Domingo
Background and Aims Predictors of first-generation somatostatin receptor ligands (fgSRLs) response in acromegaly have been studied for over 30 years, but they are still not recommended in clinical guidelines. Is there not enough evidence to support their use? This systematic review aims to describe the current knowledge of the main predictors of fgSRLs response and discuss their current usefulness
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Acromegalic Cardiomyopathy: An Entity on its own? The Effects of GH and IGF-I Excess and Treatment on Cardiovascular Risk Factors Arch. Med. Res. (IF 7.7) Pub Date : 2023-11-30 Peter Wolf, Luigi Maione, Peter Kamenický, Philippe Chanson
Acromegaly is a chronic disease resulting from constantly elevated concentrations of growth hormone (GH) and insulin-like growth factor I (IGF-I). If not adequately treated, GH and IGF-I excess is associated with various cardiovascular risk factors. These symptoms mainly include hypertension and impaired glucose metabolism, which can be observed in approximately one-third of patients. Other comorbidities
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Clavulanic Acid and its Potential Therapeutic Effects on the Central Nervous System Arch. Med. Res. (IF 7.7) Pub Date : 2023-12-01 Luis Gerardo Balcazar-Ochoa, Rosa Ventura-Martínez, Guadalupe Esther Ángeles-López, Claudia Gómez-Acevedo, Omar Francisco Carrasco, Raúl Sampieri-Cabrera, Anahí Chavarría, Abimael González-Hernández
Clavulanic acid (CLAV) is a non-antibiotic β-lactam that has been used since the late 1970s as a β-lactamase inhibitor in combination with amoxicillin, another ß-lactam with antibiotic activity. Its long-observed adverse reaction profile allows it to say that CLAV is a well-tolerated drug with mainly mild adverse reactions. Interestingly, in 2005, it was discovered that β-lactams enhance the astrocytic
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Association Between Human Metabolomics and Rheumatoid Arthritis: A Systematic Review and Meta-analysis Arch. Med. Res. (IF 7.7) Pub Date : 2023-11-28 Lili Song, Jiayi Wang, Yue Zhang, Xingxu Yan, Junjie He, Jiaxuan Nie, Fangfang Zhang, Rui Han, Hongqing Yin, Jingfang Li, Huimin Liu, Liping Huang, Yubo Li
Objective The underdiagnosis and inadequate treatment of rheumatoid arthritis (RA) can be attributed to the various clinical manifestations presented by patients. To address this concern, we conducted an extensive review and meta-analysis, focusing on RA-related metabolites. Methods A comprehensive literature search was conducted in PubMed, the Cochrane Library, Web of Science, and Embase to identify
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Ectopic Hormonal Syndromes: Cushing's Syndrome and Acromegaly Arch. Med. Res. (IF 7.7) Pub Date : 2023-11-25 Claudia Ramirez-Renteria
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Prospective Integrated Individualized Clinical Decision-making and Outcome Evaluation for Surgery in Patients with Acromegaly: A New Paradigm? Arch. Med. Res. (IF 7.7) Pub Date : 2023-11-25 Marco Johanna Theodorus Verstegen, Leontine Erica Henriette Bakker, Friso de Vries, Pieter Schutte, Iris Catharina Maria Pelsma, Wouter Ralph van Furth, Nienke Ruurdje Biermasz
Background Growth-hormone-producing pituitary adenomas have variable likelihood for biochemical remission (BR). During preoperative counseling, individual estimated surgical likelihoods/risks should be balanced against alternative (medical) treatments, which is necessary for accurate outcome presentation. Preoperative estimation of BR or total resection (TR) likelihoods have not been reported, resulting
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Genetic Testing in Hereditary Pituitary Tumors Arch. Med. Res. (IF 7.7) Pub Date : 2023-11-24 Gamze Akkuş, Márta Korbonits
Genetic testing is becoming part of mainstream endocrinology. An increasing number of rare and not-so-rare endocrine diseases have an identifiable genetic cause, either at the germline or at the somatic level. Here we summerise germline genetic alterations in patients with pituitary neuroendocrine tumors (pituitary adenomas). These may be disorders with isolated pituitary tumors, such as X-linked acrogigantism
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Acromegaly and Cancer: An Update Arch. Med. Res. (IF 7.7) Pub Date : 2023-11-24 Karina Danilowicz, Soledad Sosa
Acromegaly is a chronic and rare disease. The diagnosis usually takes several years. Multiple comorbidities are associated with acromegaly. Long-term exposure to growth factors may lead to complications such as the development of benign or malignant tumors. However, the association between acromegaly and cancer remains a matter of debate due to multiple limitations in epidemiological data. There is
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Pharmacological Treatment of Non-Functioning Pituitary Adenomas Arch. Med. Res. (IF 7.7) Pub Date : 2023-11-22 Guadalupe Vargas-Ortega, Baldomero Gonzalez-Virla, Carlos Alfonso Romero-Gameros
Treatment strategies for NFPA include surgery, radiotherapy, medical treatment, or follow-up. The treatment of NFPAs with compressive symptoms is surgical. However, in case of post-surgical tumor remnants, there may be treatment strategies that include observation and radiotherapy. Recently, medical treatment with cabergoline (CAB) has been recommended to contain and/or reduce the size of the tumor
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Integrative Placental Multi-Omics Analysis Reveals Perturbed Pathways and Potential Prognostic Biomarkers in Gestational Hypertension Arch. Med. Res. (IF 7.7) Pub Date : 2023-11-18 Bincy Varghese, Sreeranjini Babu, Aishwarya Jala, Panchanan Das, Rajesh Raju, Roshan M Borkar, Ramu Adela
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Impulse Control Disorders in Patients with Pituitary Tumors Treated with Dopamine Agonists: A Systematic Review Arch. Med. Res. (IF 7.7) Pub Date : 2023-11-19 Ross Hamblin, Niki Karavitaki
Background The increased prevalence of Impulse Control Disorders (ICDs) in dopamine agonist (DA) treated patients with Parkinson's disease is well described. Despite the frequent use of DAs in the management of pituitary tumors, the relationship between DAs and prevalence of ICDs in patients with pituitary tumours is unclear. Aims To establish the prevalence of ICDs in patients with prolactinoma or
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Genomics, Transcriptomics, and Epigenetics of Sporadic Pituitary Tumors Arch. Med. Res. (IF 7.7) Pub Date : 2023-11-18 Daniel Marrero-Rodríguez, Sandra Vela-Patiño, Florencia Martinez-Mendoza, Alejandra Valenzuela-Perez, Eduardo Peña-Martínez, Amayrani Cano-Zaragoza, Jacobo Kerbel, Sergio Andonegui-Elguera, Shimon S. Glick-Betech, Karla X. Hermoso-Mier, Sophia Mercado-Medrez, Alberto Moscona-Nissan, Keiko Taniguchi-Ponciano, Moises Mercado
Pituitary tumors (PT) are highly heterogeneous neoplasms, comprising functioning and nonfunctioning lesions. Functioning PT include prolactinomas, causing amenorrhea-galactorrhea in women and sexual dysfunction in men; GH-secreting adenomas causing acromegaly-gigantism; ACTH-secreting corticotrophinomas causing Cushing disease (CD); and the rare TSH-secreting thyrotrophinomas that result in central
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Pharmacological Treatment of Cushing's Syndrome Arch. Med. Res. (IF 7.7) Pub Date : 2023-11-15 Frederic Castinetti
The 1st line treatment of Cushing's syndrome is surgery, whatever the aetiology. The role of pharmacological treatment is clear in cases where surgery fails or is impossible, in cases of metastases, or while awaiting the delayed effects of radiotherapy. However, certain situations remain controversial, in particular the possible role of pharmacological treatment as a preparation for surgery. This situation
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H_GF 478 Clinics full BW.pdf+A38 Arch. Med. Res. (IF 7.7) Pub Date : 2023-11-14
Abstract not available
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H_GF 510 E-Alert mo23648 full BW.pdf Arch. Med. Res. (IF 7.7) Pub Date : 2023-11-14
Abstract not available
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Obesity as a Neuroendocrine Disorder Arch. Med. Res. (IF 7.7) Pub Date : 2023-11-07 Aldo Ferreira-Hermosillo, Regina de Miguel Ibañez, Enid Karina Pérez-Dionisio, Karen Alexandra Villalobos-Mata
Obesity is one of the most prevalent diseases in the world. Based on hundreds of clinical and basic investigations, its etiopathogenesis goes beyond the simple imbalance between energy intake and expenditure. The center of the regulation of appetite and satiety lies in the nuclei of the hypothalamus where peripheral signals derived from adipose tissue (e.g., leptin), the gastrointestinal tract, the
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Radiotherapy and Mortality in Pituitary Adenomas Arch. Med. Res. (IF 7.7) Pub Date : 2023-11-06 Baldomero González-Virla, Guadalupe Vargas-Ortega, Carlos Alfonso Romero-Gameros
Background Pituitary adenomas (PA), comprising 10–20% of intracranial tumors, are classified as functioning and non-functioning and are further divided by size. Non-functioning tumors cause mechanical symptoms while functioning ones result in hormonal hypersecretion syndromes. Initial treatment involves surgery, with medical treatment for prolactinomas. Radiotherapy (RT) is employed as an adjuvant
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Clinical Spectrum of USP8 Pathogenic Variants in Cushing's Disease Arch. Med. Res. (IF 7.7) Pub Date : 2023-11-02 Rosa G. Rebollar-Vega, Julia M. Zuarth-Vázquez, Laura C. Hernández-Ramírez
Cushing's disease (CD) is a life-threatening condition with a challenging diagnostic process and scarce treatment options. CD is caused by usually benign adrenocorticotrophic hormone (ACTH)-secreting pituitary neuroendocrine tumors (PitNETs), known as corticotropinomas. These tumors are predominantly of sporadic origin, and usually derive from the monoclonal expansion of a mutated cell. Somatic activating
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Hirsutism and Polycystic Ovarian Morphology are the Most Frequent Components of Polycystic Ovary Syndrome in Women with Type 1 Diabetes Arch. Med. Res. (IF 7.7) Pub Date : 2023-10-20 Manuel R. García-Sáenz, Miry Lobaton-Ginsberg, Claudia Ramírez-Rentería, Nitzia López-Juárez, Renata Saucedo, Jorge Valencia-Ortega, Aldo Ferreira-Hermosillo
Background Polycystic ovarian syndrome (PCOS) is one of the most common endocrine disorders in women of reproductive age. In Mexico, its prevalence in patients with type 1 diabetes (T1D) is unknown. Aim To evaluate the clinical and biochemical characteristics of patients with T1D with and without PCOS. Methods A cross-sectional study was conducted to evaluate women of reproductive age with T1D for
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Machine Learning-Based Integration Develops a Macrophage-Related Index for Predicting Prognosis and Immunotherapy Response in Lung Adenocarcinoma Arch. Med. Res. (IF 7.7) Pub Date : 2023-10-19 Zuwei Li, Minzhang Guo, Wanli Lin, Peiyuan Huang
Background Macrophages play a critical role in tumor immune microenvironment (TIME) formation and cancer progression in lung adenocarcinoma (LUAD). However, few studies have comprehensively and systematically described the characteristics of macrophages in LUAD. Methods This study identified macrophage-related markers with single-cell RNA sequencing data from the GSE189487 dataset. An integrative machine
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Gene Expression Changes in the Ovary Mediate Non-Anovulatory Mechanisms of Contraception with Levonorgestrel Arch. Med. Res. (IF 7.7) Pub Date : 2023-10-05 Gabriela Hernández-Silva, Claudia Cecilia Vega, David Barrera, Rogelio Hernández-Pando, Pablo Ángel García-Uribe, Mayel Chirinos, Fernando Larrea
Background Emergency contraception with levonorgestrel (LNG) is a viable option to prevent unintended pregnancies. Although the efficacy of LNG as an anovulatory agent decreases as treatment approaches ovulation, it still provides some contraceptive benefits. Aim To better understand the contraceptive mechanisms of LNG in ovulatory subjects. Methods We conducted a study on Wistar rats that received
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LZTS3/TAGLN Suppresses Cancer Progression in Human Colorectal Adenocarcinoma Through Regulating Cell Proliferation, Migration, and Actin Cytoskeleton Arch. Med. Res. (IF 7.7) Pub Date : 2023-10-06 Xinpei Gu, Shuhui Chen, Zhaojin Wang, Qianwen Bu, Shuhong An
Background Numerous studies have confirmed that the leucine zipper tumor suppressor (LZTS) gene family plays a vital role in modulating transcription and cell cycle control, especially in colorectal cancer. This study aimed to evaluate the potential of leucine zipper tumor suppressor family member 3 (LZTS3) as a marker for COAD. Methods Bioinformatics, immunohistochemistry, and Western blotting were
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Long-term Discontinuation of Dopamine Agonist Treatment in Patients with Prolactinomas Revisited Arch. Med. Res. (IF 7.7) Pub Date : 2023-10-06 Ernesto Sosa-Eroza, Etual Espinosa-Cárdenas
The most common type of functioning pituitary adenomas is prolactinomas; unlike other types, they are treated medically with dopamine agonists (DA). This treatment aims to normalize PRL levels and decrease tumor size by 50% or more. These objectives are typically achieved by 90% of patients with microprolactinoma, two-thirds of those with macroprolactinomas, and about half of those with giant prolactinomas
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Non-Invasive Biochemical Testing of ACTH-dependent Cushing's Disease: Do We Still Need Petrosal Sinus Sampling? Arch. Med. Res. (IF 7.7) Pub Date : 2023-09-23 Etual Espinosa-Cardenas, Manuel Garcia-Saenz, Ana Laura Espinosa de los Monteros-Sanchez, Ernesto Sosa-Eroza
Differentiating between a pituitary from an ectopic source of ACTH could be a real one of the major challenges of clinical endocrinology. The Bilateral inferior petrosal sinus sampling (BIPSS) is considered the gold standard for identifying the source of ACTH; however, is not available worldwide. After the SARS-CoV-2 pandemic, algorithms that include biochemical and imaging tests have gained importance
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Angiotensin Receptor Blockers Restore Skeletal Muscle in Patients with Chronic Obstructive Pulmonary Disease Arch. Med. Res. (IF 7.7) Pub Date : 2023-09-21 Rizwan Qaisar, Hossam Kamli, Asima Karim, Tahir Muhammad, Firdos Ahmad, Ahmad Shaikh
Background Age-related muscle decline, called sarcopenia, and hypertension are commonly observed in patients with chronic obstructive pulmonary disease (COPD). Angiotensin receptor blockers (ARBs) are common antihypertensive medications with muscle protective effects. However, the anti-sarcopenic potential and associated mechanisms of ARBs in hypertensive patients with COPD are unknown. Objectives
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Exploring the Interplay Between Vitamin B12-related Biomarkers, DNA Methylation, and Gene-Nutrition Interaction in Esophageal Precancerous Lesions Arch. Med. Res. (IF 7.7) Pub Date : 2023-09-20 Da Pan, Ming Su, Dengfeng Xu, Yuanyuan Wang, Han Gao, James Daniel Smith, Jihan Sun, Xin Wang, Qingyang Yan, Guang Song, Yifei Lu, Wuqiong Feng, Shaokang Wang, Guiju Sun
Background Vitamin B12 depletion has been suggested to be associated with esophageal precancerous lesions (EPL). However, the potential mechanisms remain unclear. Aims This study aims to evaluate the role of vitamin B12 and its regulated epigenetic modification in EPL and provide preliminary information on the identification of potential molecular biomarkers for the early prediction of EPL. Methods
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Tumor-derived Endothelial Cell: Important Etiological Factors in Endometriosis Arch. Med. Res. (IF 7.7) Pub Date : 2023-09-20 Yishan Dong, Ming Zhang, Jun OuYang, Wenbai Zhou, Bin Yu
Background and Aim Endometriosis (EMS) is a very complex disease with high heterogeneity. Recently, single-cell RNA sequencing (scRNA-seq) has been applied to comprehensively characterize cellular heterogeneity. Here, we built a new transcriptomic profile of EMS cellular signatures. Methods Three women diagnosed with endometriosis were recruited. Their fresh eutopic endometrium (EM) and ectopic endometrium
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Prolactinomas Resistant to Dopamine Agonists: Pathophysiology and Treatment Arch. Med. Res. (IF 7.7) Pub Date : 2023-09-07 Ilan Shimon
Prolactinomas are the most common functional pituitary tumors, accounting for 40% of all pituitary adenomas. Medical treatment with dopamine agonists (DA), mainly cabergoline, is considered the primary therapy for these patients. Prolactin normalization is achieved in 80–90% of prolactinomas treated with cabergoline. Patients resistant to the standard dose can escalate the dose of cabergoline up to
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Effect of Insulin Resistance on Abdominal Obesity, Liver Fat Infiltration, and Body Mass Index in Youngsters Arch. Med. Res. (IF 7.7) Pub Date : 2023-09-01 Esperanza Milagros García-Oropesa, Adriana L. Perales-Torres, Yoscelina Estrella Martínez-López, Claudia X. Munguía-Cisneros, Edna J. Nava-González, Monserrat Pérez-Navarro, Marisol Rosas-Díaz, Neyla Baltazar, América Arroyo-Valerio, Alvaro Diaz-Badillo, Octelina Castillo-Ruiz, Joselín Hernández-Ruiz, Srinivas Mummidi, Laura Y. Ramírez-Quintanilla, Alejandra Bustamante, Carlos Ramirez-Pfeiffer, Leonel
Aim Evaluate insulin resistance (IR) as a mediator of the effect of body fat distribution on liver fat infiltration and stiffness (LSt) in young adults using structural equation modeling (SEM). Methods We invited 500 first year students from two universities and evaluated their family history to determine the risk for cardiometabolic disease. Of these, 174 students (age 19 ± 1 years) were assessed
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Efficacy and Safety of Pegvisomant in the Treatment of Acromegaly Arch. Med. Res. (IF 7.7) Pub Date : 2023-09-01 Linus Haberbosch, Christian J. Strasburger
Pegvisomant, the first and currently only clinically available growth hormone receptor antagonist, is an effective therapeutic option for the medical treatment of acromegaly, a rare disorder characterized by excessive growth hormone secretion. With now over 20 years of real world experience, its safety and efficacy is well-established. However, several aspects of its clinical use are still controversially
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Maximizing the Value of Routine Hospital Data for Better Understanding of HIV Medication Adherence in Low-Resourced Settings Arch. Med. Res. (IF 7.7) Pub Date : 2023-08-26 SAMUEL KIZITO, DOROTHY NAMPIJJA
Abstract not available
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Current and Future Perspectives of Microscopic and Endoscopic Transsphenoidal Surgery for Pituitary Adenomas: A Narrative Review Arch. Med. Res. (IF 7.7) Pub Date : 2023-08-24 Gerardo Guinto, Gerardo Y. Guinto-Nishimura, Marcos V. Sangrador-Deitos, Rodrigo Uribe-Pacheco, Rene Soto-Martinez, David Gallardo, Patricia Guinto, Alejandro Vargas, Norma Aréchiga
Transsphenoidal resection remains the standard treatment for most pituitary adenomas. However, the ideal surgical approach to safely access these lesions, either microsurgical or endoscopic, continues to be debated. Since the introduction of endoscopic transsphenoidal surgery, centers around the world have increasingly adopted this technique, experiencing a shift away from the conventional microsurgical
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HbA1c without Complete Blood Count: What are we missing? — A viewpoint from South-East Asia Arch. Med. Res. (IF 7.7) Pub Date : 2023-08-21 Yashendra Sethi, Nimrat Khehra, Inderbir Padda, Nidhi Uniyal, Jeffrey Olson
Abstract not available
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Multimorbidity, Functionality, Socioeconomic and Behavioral Conditions Linked with Mortality in a Cohort of Adults: A Latent Class Analysis Arch. Med. Res. (IF 7.7) Pub Date : 2023-08-16 Dolores Mino-León, Liliana Giraldo-Rodríguez, Abigail Rojas-Huerta, Francisco Javier Prado-Galbarro, Hortensia Reyes-Morales
Background Aging and multimorbidity (MM) are not enough to explain patient heterogeneity and outcomes. The objective of this study was to estimate the effect of multimorbidity patterns and indicators of socioeconomic, behavioral, and functional dimensions on the risk of death in a cohort of people ≥50 years old. Methods We analyzed a cohort of 7,342 persons ≥50 years old from the Mexican Health and
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Venovenous Extracorporeal Membrane Oxygenation in Refractory Hypoxemia Arch. Med. Res. (IF 7.7) Pub Date : 2023-08-16 ENRIQUE MONARES-ZEPEDA, URIEL CHAVARRIA-MARTINEZ, MELISSA GARCIA-LEZAMA, ERNESTO ROLDAN-VALADEZ
Abstract not available
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Mortality Prognosis Factors in Patients with Active Cancer Under Treatment, and Severe COVID-19 Arch. Med. Res. (IF 7.7) Pub Date : 2023-08-14 Paula Cabrera-Galeana, Nancy Reynoso-Noverón, Carlos González-Nuñez, Oscar Arrieta, Juan Torres, Silvia Allende, Diana Vilar-Compte, Consuelo Díaz, Claudia Cano, Miguel Álvarez, Alejandro Mohar
Background COVID-19 is associated with systemic inflammation. This inflammatory response is further deregulated by oncological treatments increasing mortality in this population. However, there is conflicting information regarding the clinical factors that increase mortality in patients with severe COVID-19. Objective The aim of this study was to identify prognostic factors associated with mortality
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ChatGPT and Artificial Intelligence in the Contemporary Medical Landscape: Commentary Arch. Med. Res. (IF 7.7) Pub Date : 2023-08-09 AMNUAY KLEEBAYOON, VIROJ WIWANITKIT
Abstract not available
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Clinical Findings and Genetic Analysis of Nine Mexican Families with Bartter Syndrome Arch. Med. Res. (IF 7.7) Pub Date : 2023-07-27 Norma E. Guerra Hernández, Laura I. Escobar Pérez, Dora Aguilera, María Dolores Camargo-Muñiz, Cinthya Fabiola Ceceña Espinosa, María de la Cruz Ruiz Jaramillo, Carolina Salvador, Zinaeli López González, Marguerite Hureaux, Rosa Vargas-Poussou
Background Bartter's syndrome (BS) is a group of salt-wasting tubulopathies characterized by hypokalemia, metabolic alkalosis, hypercalciuria, secondary hyperaldosteronism, and low or normal blood pressure. Loss-of-function variants in genes encoding for five proteins expressed in the thick ascending limb of Henle in the nephron, produced different genetic types of BS. Aim Clinical and genetic analysis