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  • Taking the neglected out of neglected tropical diseases
    Lancet Glob. Health (IF 15.873) Pub Date : 2020-02-01
    The Lancet Global Health

    In December, 2019, Nairobi, Kenya hosted the first international conference on neglected tropical diseases (NTDs) in Africa. The theme, “cross-border partnership towards achieving control and elimination of NTDs”, recognised that cooperation beyond national borders is crucial for success in the fight against NTDs. The importance of collaboration to control NTDs came to global attention in 2012, with the launch of the and the London Declaration on NTDs, which saw governments, donors, multilateral agencies, non-governmental organisations, and pharmaceutical companies coming together to commit to control, eliminate, or eradicate ten of WHO's priority NTDs by 2020. Jan 30 will mark 8 years since the London Declaration on NTDs. That same date will also mark the inaugural .

    更新日期:2020-01-23
  • Global burden of cancer attributable to infections: the critical role of implementation science
    Lancet Glob. Health (IF 15.873) Pub Date : 2020-02-01
    Anne F Rositch

    Despite significant advances in methodology and data quality since the first estimation of the global burden of cancer attributable to infections, one key fact remains: infections are responsible for at least a sixth of all cancer cases worldwide.,  ,  ,  In the latest set of estimates in this issue of The Lancet Global Health, Catherine de Martel and colleagues use newly released 2018 GLOBOCAN cancer incidence data to estimate for the first time age-standardised incidence rates of infection-attributable cancers at the country, regional, and global level. While many sources of uncertainty remain (including global variations in data completeness, quality of case detection and inclusion in cancer registries, and challenges in estimation of population denominators), incidence rates, as opposed to attributable fractions, provide policy makers with a more actionable metric of the burden of infection-associated cancers within and between populations over time. De Martel and colleagues report an astounding 25 cases of infection-attributable cancer per 100 000 people in 2018, with global variation ranging from 38 and 33 cases per 100 000 in eastern Asia and sub-Saharan Africa, respectively, to 14 cases per 100 000 in northern Europe and western Asia.

    更新日期:2020-01-23
  • Evidence for the path to cervical cancer elimination
    Lancet Glob. Health (IF 15.873) Pub Date : 2019-12-04
    Afsan Bhadelia

    Elimination of cervical cancer is at the forefront of the global health agenda with the launch of the WHO Initiative for the Elimination of Cervical Cancer in 2018. Human papillomavirus (HPV) vaccination is expected to be a priority agenda item on health for the 2020 G20 Summit in Riyadh following the 2019 commitment to universal access to vaccination in the G20 Osaka Leaders' Declaration and the Okayama Declaration of the G20 Health Ministers. This political momentum should be coupled with the latest evidence to pinpoint outstanding areas for action and to implement responsive strategies.

    更新日期:2020-01-23
  • Challenges in quantifying the clear effect of malnutrition on diarrhoeal deaths
    Lancet Glob. Health (IF 15.873) Pub Date : 2020-02-01
    Elizabeth T Rogawski McQuade

    The vicious cycle between diarrhoea and malnutrition was described decades ago and remains a refractory problem with continued high dual burden among children in low-resource settings. An acute manifestation of the interaction between diarrhoea and malnutrition is the effect of malnutrition on diarrhoeal mortality: the risk of death is far higher among acutely malnourished children with diarrhoea compared with better nourished children with diarrhoea., 

    更新日期:2020-01-23
  • Gender-transformative programmes: implications for research and action
    Lancet Glob. Health (IF 15.873) Pub Date : 2019-12-23
    Anna Kågesten; Venkatraman Chandra-Mouli

    During the 25 years since the 1994 International Conference on Population and Development, the global health community has increasingly recognised gender as a social determinant of health. This recognition has resulted in a shift towards approaches that seek to examine and change harmful gender and power imbalances—ie, gender-transformative programmes. In The Lancet Global Health, Jessica Levy and colleagues present findings from a global systematic review on the effect of the most rigorously evaluated programmes of gender-transformative intent on the health and wellbeing of children and young people. Building on a broader review in the Lancet Series on gender equality, norms, and health, Levy and colleagues put forward several key findings with implications for research and practice.

    更新日期:2020-01-23
  • Evidence for visceral leishmaniasis elimination in Nepal
    Lancet Glob. Health (IF 15.873) Pub Date : 2020-02-01
    Megha Raj Banjara; Anand Ballabh Joshi

    Visceral leishmaniasis is an important public health problem in Nepal. In 2005, Bangladesh, India, and Nepal signed a memorandum of understanding to eliminate visceral leishmaniasis in this region by 2015. As the elimination target was not reached in 2015, the date has been extended to 2020. The visceral leishmaniasis elimination strategy emphasised early case detection, effective treatment, integrated vector management, and reduced transmission. Although Nepal achieved elimination targets in all 12 visceral leishmaniasis endemic districts from 2013 and thereafter, one of the previously non-endemic districts crossed the elimination target in 2017, however, this achieved target is not sustainable. A substantial reduction of visceral leishmaniasis incidence has been observed in the Indian subcontinent and Nepal has reduced its visceral leishmaniasis incidence by 90% compared with 2005. Despite this progress, the disease has now been reported in new ecological niches and hilly districts of Nepal in which there is no visceral leishmaniasis control programme., 

    更新日期:2020-01-23
  • Evaluating the impact of Georgia's hepatitis C elimination plan: lessons learned for the global initiative
    Lancet Glob. Health (IF 15.873) Pub Date : 2019-12-18
    Yvan Hutin; Niklas Luhmann; Philippa Easterbrook

    In 2015, Georgia was faced with one of the highest prevalence levels of hepatitis C virus (HCV) infection worldwide (5·4%, with 150 000 adults infected). An injection drug use epidemic along with unsafe health-care practices led to large-scale transmission in the 1990s. In 2015, Georgia adopted a plan to eliminate HCV by 2020 (ie, reduce the prevalence of HCV infection by 90% by 2020).,  Between May, 2015, and February, 2019, there has been progressive scale-up of testing and 54 313 patients have been treated. In The Lancet Global Health, Josephine Walker and collaborators report on a dynamic transmission compartmental model that used Georgian data from the national biomarker survey and two biobehavioural surveys among people who inject drugs. They projected the effect of diagnosis and treatment activities on incidence, prevalence, and mortality and calculated the treatment rates required to reach the 90% prevalence reduction target. The model suggests that compared with 2015, both incidence and prevalence had fallen by 37% and that mortality was reduced by 14%. It also suggests that if Georgia aims to reach its 90% prevalence reduction target by 2020, the treatment initiation rate should be increased from 1000 to 4000 individuals initiating treatment per month. Alternatively, the duration of the programme could be prolonged to 2026.

    更新日期:2020-01-23
  • Guided self-help to reduce psychological distress: what's the potential for scaling up?
    Lancet Glob. Health (IF 15.873) Pub Date : 2020-02-01
    Charlotte Hanlon; Mark Jordans

    In their cluster randomised controlled trial of guided self-help to reduce psychological distress in female Sudanese refugees in The Lancet Global Health, Wietse A Tol and colleagues have taken global mental health to a new and hopeful place. The intervention of guided self-help was delivered in exacting conditions in a refugee settlement to women who had high exposure to trauma, and where mental health specialists are scarce. No psychiatric diagnosis was required to receive the intervention, and women did not need to disclose exposure to sensitive traumatic experiences. The only inclusion criterion was that women reported at least moderate levels of psychological distress. The premise of the intervention was that existing coping strategies could be helpfully and appropriately supported to alleviate symptoms of mental ill health. The findings indicate that this was a successful approach, with women in the intervention group having reduced levels of distress, fewer symptoms of depression and post-traumatic stress, improvement in functioning, and improvement in overall wellbeing. In summary, guided self-help is a low-intensity psychosocial intervention that minimises risk of stigma, focuses on positive mental health, and is effective. The question now is how can this promising and potentially scalable intervention be transitioned to make real-world impact? We discuss four considerations for scale-up.

    更新日期:2020-01-23
  • The power of peers and community in the continuum of HIV care
    Lancet Glob. Health (IF 15.873) Pub Date : 2020-01-07
    Anna T Grimsrud; Carey Pike; Linda-Gail Bekker

    Diagnosing the estimated 38 million people living with HIV globally and ensuring they are linked to, and remain fully adherent to, their lifelong antiretroviral therapy (ART) is an unprecedented global public health intervention. ART adherence ensures not only the wellbeing of people with HIV but also the reduction in horizontal and vertical transmission that viral suppression can bring. That low-income and middle-income countries, especially in sub-Saharan Africa, with sometimes fragile and inadequate health systems account for the majority of people with HIV gives context to the extent of this challenge.

    更新日期:2020-01-23
  • Azithromycin for child survival: digging without getting too dirty into the differential effect on cause-specific mortality
    Lancet Glob. Health (IF 15.873) Pub Date : 2020-02-01
    Lola Madrid; Quique Bassat

    A decade ago, the astonishing and unexpected results of a trachoma trial in Ethiopia hinted at the exciting potential of mass azithromycin distribution to significantly reduce all-cause mortality in children by approximately 50%. In 2018, the Macrolides Oraux pour Réduire les Décès avec un Oeil sur la Résistance (MORDOR) multi-country study,,  designed to investigate the effect of mass biannual azithromycin distribution on all-cause mortality in children aged 1–59 months in sub-Saharan African communities, corroborated these results—although with more modest and credible findings than the trachoma trial. The greatest reduction in all-cause mortality was observed in Niger, the site with the highest baseline mortality, where biannual mass distribution of azithromycin to children aged 1–59 months decreased all-cause mortality by 18% compared with placebo. The results of the MORDOR trial, however, raised many questions about the mechanisms by which azithromycin could have such an effect on child mortality. The direct and indirect (ie, herd protection) therapeutic and chemoprophylactic effects of macrolides against a series of pathogens (either carried asymptomatically or overtly causing disease), their immunomodulatory benefits, or their effect on the human microbiome by promoting a so-called protective composition (ie, against superinfections), are all plausible explanations; the contributions of which remain a matter of scientific speculation. There were high expectations of the MORDOR trial to clearly establish the necessary mechanisms underlying the effects of mass azithromycin distribution in reducing all-cause mortality in children.

    更新日期:2020-01-23
  • Point-of-care HPV molecular diagnostics for a test-and-treat model in high-risk HIV populations
    Lancet Glob. Health (IF 15.873) Pub Date : 2020-02-01
    Shahin Sayed; Michael Chung; Marleen Temmermans

    Strategies for cervical cancer prevention and control in low-income and middle-income countries (LMICs) require concerted efforts to improve screening and access to treatment, especially in high-risk HIV populations. LMICs bear the burden of HIV infection, human papillomavirus (HPV) infection is common among HIV-infected women, risk of cervical cancer is increased in , and HIV clinics provide opportunities to screen and treat for cervical cancer in this population.

    更新日期:2020-01-23
  • The elimination of measles in Iran
    Lancet Glob. Health (IF 15.873) Pub Date : 2020-02-01
    Saeed Namaki; Mohammad Mehdi Gouya; Seyed Mohsen Zahraei; Neda Khalili; Hossein Sobhani; Mohammad Esmaeil Akbari

    Measles is a febrile disease that is considered to be one of the world's most contagious viral diseases. Despite the existence of a safe, available, inexpensive, and highly effective vaccine, measles is still a global imperative, causing more than 100 000 deaths per year, which could be prevented through vaccination.

    更新日期:2020-01-23
  • Optimising TRIUMPH with 6·25 mg chlorthalidone
    Lancet Glob. Health (IF 15.873) Pub Date : 2020-02-01
    Anil Pareek; C Venkata S Ram; Ravi T Mehta; Shruti Dharmadhikari

    The TRIUMPH trial found that use of the low-dose fixed-combination triple pill as initial therapy provided better blood pressure control than usual care. In their modelled economic evaluation of TRIUMPH, Thomas Lung and colleagues reported that this triple-pill strategy is cost-effective as a first-line treatment option, especially for older individuals. For their analysis, the authors referred to WHO-CHOICE, which includes health system costs associated with clinic visits, medications, and inpatient hospital admissions, but excludes those associated with laboratory examinations. This is important because the higher-dose triple pill includes 25 mg chlorthalidone, and the following points must be considered.

    更新日期:2020-01-23
  • Optimising TRIUMPH with 6·25 mg chlorthalidone – Authors' reply
    Lancet Glob. Health (IF 15.873) Pub Date : 2020-02-01
    Thomas Lung; Anthony Rodgers; Tracey-Lea Laba; Ruth Webster; Anushka Patel

    We thank Anil Pareek and colleagues for their suggestion that lower doses of chlorthalidone could reduce metabolic side-effects and improve the cost-effectiveness of a low-dose triple-pill strategy. Although moderate-to-high doses of thiazide-like diuretics have provided large reductions in cardiovascular events in previous trials, we agree there would be considerable clinical value in regimens with greater blood pressure lowering efficacy and fewer side-effects.

    更新日期:2020-01-23
  • Why is polio still here? A perspective from Pakistan
    Lancet Glob. Health (IF 15.873) Pub Date : 2020-02-01
    Rana Jawad Asghar

    Poliomyelitis has been eradicated in all countries except Afghanistan and Pakistan. Why have we, as Pakistani government workers, public health officials, and community members been unable to eradicate polio in Pakistan? There is no doubt that our field immunisation staff and the security personnel protecting them have faced unprecedented attacks in a difficult, and in some cases, deadly, working environment. But with the security situation now much improved, the question of why we are witnessing one of the largest polio surges since 2014 remains unanswered. Pakistan had 91 cases of polio as of Nov 26, 2019. Not only have we had a major outbreak in Khyber Pakhtunkhwa, but all other provinces in Pakistan have also reported multiple cases. In 2018 we had 12 cases, and in 2017 we had only eight cases. Multiple explanations have been put forward from national elections, transition of government, underlying issues of community distrust of vaccinations, to negligence of key staff., 

    更新日期:2020-01-23
  • Correction to Lancet Glob Health 2019; 7: e1448–57
    Lancet Glob. Health (IF 15.873) Pub Date : 2020-02-01

    Celhay P, Martinez S, Muñoz M, Perez M, Perez-Cuevas R. Long-term effects of public health insurance on the health of children in Mexico: a retrospective study. Lancet Glob Health 2019; 7: e1448–57—In this Article, the Research in context panel has been modified to include an additional sentence, and the second sentence of the second paragraph of the Discussion has been changed to include an additional citation. This correction has been made as of Jan 22, 2020.

    更新日期:2020-01-23
  • Correction to Lancet Glob Health 2019; published online Dec 4. https://doi.org/10.1016/S2214-109X(19)30523-6
    Lancet Glob. Health (IF 15.873) Pub Date : 2019-12-13

    Bhadelia A. Evidence for the path to cervical cancer elimination. Lancet Glob Health 2019; published online Dec 4. https://doi.org/10.1016/S2214-109X(19)30523-6—In this Comment, “eradication” should read “elimination”. These corrections have been made as of Dec 13, 2019.

    更新日期:2020-01-23
  • Correction to Lancet Glob Health 2020; 8: e23–24
    Lancet Glob. Health (IF 15.873) Pub Date : 2019-12-19

    Neil M, Saenz C. Advancing research ethics systems in Latin America and the Caribbean: a path for other LMICs? Lancet Glob Health 2020; 8: e23–24—This Comment had incorrect copyright information. This correction has been made as of Dec 19, 2019.

    更新日期:2020-01-23
  • Global burden of cancer attributable to infections in 2018: a worldwide incidence analysis
    Lancet Glob. Health (IF 15.873) Pub Date : 2019-12-17
    Catherine de Martel; Damien Georges; Freddie Bray; Jacques Ferlay; Gary M Clifford
    更新日期:2020-01-23
  • Estimates of incidence and mortality of cervical cancer in 2018: a worldwide analysis
    Lancet Glob. Health (IF 15.873) Pub Date : 2019-12-04
    Marc Arbyn; Elisabete Weiderpass; Laia Bruni; Silvia de Sanjosé; Mona Saraiya; Jacques Ferlay; Freddie Bray
    更新日期:2020-01-23
  • Diarrhoeal disease and subsequent risk of death in infants and children residing in low-income and middle-income countries: analysis of the GEMS case-control study and 12-month GEMS-1A follow-on study
    Lancet Glob. Health (IF 15.873) Pub Date : 2019-12-18
    Myron M Levine; Dilruba Nasrin; Sozinho Acácio; Quique Bassat; Helen Powell; Sharon M Tennant; Samba O Sow; Dipika Sur; Anita K M Zaidi; Abu S G Faruque; M Jahangir Hossain; Pedro L Alonso; Robert F Breiman; Ciara E O'Reilly; Eric D Mintz; Richard Omore; John B Ochieng; Joseph O Oundo; Boubou Tamboura; Doh Sanogo; Uma Onwuchekwa; Byomkesh Manna; Thandavarayan Ramamurthy; Suman Kanungo; Shahnawaz Ahmed; Shahida Qureshi; Farheen Quadri; Anowar Hossain; Sumon K Das; Martin Antonio; Debasish Saha; Inacio Mandomando; William C Blackwelder; Tamer Farag; Yukun Wu; Eric R Houpt; Jaco J Verweiij; Halvor Sommerfelt; James P Nataro; Roy M Robins-Browne; Karen L Kotloff
    更新日期:2020-01-23
  • The effect of acute malnutrition on enteric pathogens, moderate-to-severe diarrhoea, and associated mortality in the Global Enteric Multicenter Study cohort: a post-hoc analysis
    Lancet Glob. Health (IF 15.873) Pub Date : 2020-02-01
    Kirkby D Tickell; Rumana Sharmin; Emily L Deichsel; Laura M Lamberti; Judd L Walson; A S G Faruque; Patricia B Pavlinac; Karen L Kotloff; Mohammod J Chisti
    更新日期:2020-01-23
  • Characteristics of successful programmes targeting gender inequality and restrictive gender norms for the health and wellbeing of children, adolescents, and young adults: a systematic review
    Lancet Glob. Health (IF 15.873) Pub Date : 2019-12-23
    Jessica K Levy; Gary L Darmstadt; Caitlin Ashby; Mary Quandt; Erika Halsey; Aishwarya Nagar; Margaret E Greene
    更新日期:2020-01-23
  • Impact of the visceral leishmaniasis elimination initiative on Leishmania donovani transmission in Nepal: a 10-year repeat survey
    Lancet Glob. Health (IF 15.873) Pub Date : 2020-02-01
    Kristien Cloots; Surendra Uranw; Bart Ostyn; Narayan Raj Bhattarai; Epke Le Rutte; Basudha Khanal; Albert Picado; François Chappuis; Epco Hasker; Prahlad Karki; Suman Rijal; Marleen Boelaert
    更新日期:2020-01-23
  • Interim effect evaluation of the hepatitis C elimination programme in Georgia: a modelling study
    Lancet Glob. Health (IF 15.873) Pub Date : 2019-12-18
    Josephine G Walker; Tinatin Kuchuloria; David Sergeenko; Hannah Fraser; Aaron G Lim; Shaun Shadaker; Liesl Hagan; Amiran Gamkrelidze; Valeri Kvaratskhelia; Lia Gvinjilia; Malvina Aladashvili; Alexander Asatiani; Davit Baliashvili; Maia Butsashvili; Ivdity Chikovani; Irma Khonelidze; Irma Kirtadze; Mark H Kuniholm; David Otiashvili; Lali Sharvadze; Ketevan Stvilia; Tengiz Tsertsvadze; Mamuka Zakalashvili; Matthew Hickman; Natasha K Martin; Juliette Morgan; Muazzam Nasrullah; Francisco Averhoff; Peter Vickerman
    更新日期:2020-01-23
  • Guided self-help to reduce psychological distress in South Sudanese female refugees in Uganda: a cluster randomised trial
    Lancet Glob. Health (IF 15.873) Pub Date : 2020-02-01
    Wietse A Tol; Marx R Leku; Daniel P Lakin; Kenneth Carswell; Jura Augustinavicius; Alex Adaku; Teresa M Au; Felicity L Brown; Richard A Bryant; Claudia Garcia-Moreno; Rashelle J Musci; Peter Ventevogel; Ross G White; Mark van Ommeren
    更新日期:2020-01-23
  • Effect of a differentiated service delivery model on virological failure in adolescents with HIV in Zimbabwe (Zvandiri): a cluster-randomised controlled trial
    Lancet Glob. Health (IF 15.873) Pub Date : 2020-01-07
    Webster Mavhu; Nicola Willis; Juliet Mufuka; Sarah Bernays; Maureen Tshuma; Collin Mangenah; Hendramoorthy Maheswaran; Walter Mangezi; Tsitsi Apollo; Ricardo Araya; Helen A Weiss; Frances M Cowan
    更新日期:2020-01-23
  • Effect of facility-based HIV self-testing on uptake of testing among outpatients in Malawi: a cluster-randomised trial
    Lancet Glob. Health (IF 15.873) Pub Date : 2020-02-01
    Kathryn Dovel; Frackson Shaba; O Agatha Offorjebe; Kelvin Balakasi; Mike Nyirenda; Khumbo Phiri; Sundeep K Gupta; Vincent Wong; Chi-Hong Tseng; Brooke E Nichols; Refiloe Cele; Eric Lungu; Tobias Masina; Thomas J Coates; Risa M Hoffman
    更新日期:2020-01-23
  • Cause-specific mortality of children younger than 5 years in communities receiving biannual mass azithromycin treatment in Niger: verbal autopsy results from a cluster-randomised controlled trial
    Lancet Glob. Health (IF 15.873) Pub Date : 2020-02-01
    Jeremy D Keenan; Ahmed M Arzika; Ramatou Maliki; Sanoussi Elh Adamou; Fatima Ibrahim; Mariama Kiemago; Nana Fatima Galo; Elodie Lebas; Catherine Cook; Benjamin Vanderschelden; Robin L Bailey; Sheila K West; Travis C Porco; Thomas M Lietman; Paul M Emerson; Jerusha Weaver; Sheila K West; Robin L Bailey; John Hart; Amza Abdou; Boubacar Kadri; Nassirou Beido; E Kelly Callahan; Aisha E Stewart; Ahmed M Arzika; Sanoussi Elh Adamou; Nana Fatima Galo; Fatima Ibrahim; Salissou Kane; Mariama Kiemago; Ramatou Maliki; Catherine Cook; Sun Y Cotter; Thuy Doan; Dionna M Fry; Jeremy D Keenan; Elodie Lebas; Thomas M Lietman; Ying Lin; Kieran S O'Brien; Catherine E Oldenburg; Travis C Porco; Kathryn J Ray; Philip J Rosenthal; George W Rutherford; Benjamin Vanderschelden; Nicole E Varnado; Lina Zhong; Zhaoxia Zhou
    更新日期:2020-01-23
  • Clinical evaluation of modifications to a human papillomavirus assay to optimise its utility for cervical cancer screening in low-resource settings: a diagnostic accuracy study
    Lancet Glob. Health (IF 15.873) Pub Date : 2020-02-01
    Louise Kuhn; Rakiya Saidu; Rosalind Boa; Ana Tergas; Jennifer Moodley; David Persing; Scott Campbell; Wei-Yann Tsai; Thomas C Wright; Lynette Denny
    更新日期:2020-01-23
  • Moving towards clean cooking in China
    Lancet Glob. Health (IF 15.873) Pub Date : 2020-01-20
    Renjie Chen; Haidong Kan

    Domestic use of solid fuels is a major source of household air pollution and a substantial contributor to ambient air pollution, particularly in developing global regions. Solid fuel use can increase risks for many cardiopulmonary diseases; in the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2017, household air pollution from solid fuel use was estimated to account for about 1·6 million deaths, and this number could be underestimated in areas with a high prevalence of solid fuel use. Developing countries such as China are seeing rapid urbanisation, which is accompanied naturally by a general transition from use of solid fuels to clean energy. Accordingly, assessment of how risks and disease burden would change because of this transition, and use of ventilation facilities, is of public health importance.

    更新日期:2020-01-21
  • Cooking fuels and risk of all-cause and cardiopulmonary mortality in urban China: a prospective cohort study
    Lancet Glob. Health (IF 15.873) Pub Date : 2020-01-20
    Kuai Yu; Jun Lv; Gaokun Qiu; Canqing Yu; Yu Guo; Zheng Bian; Ling Yang; Yiping Chen; Chaolong Wang; An Pan; Liming Liang; Frank B Hu; Zhengming Chen; Liming Li; Tangchun Wu; Junshi Chen; Zhengming Chen; Robert Clarke; Rory Collins; Yu Guo; Liming Li; Jun Lv; Richard Peto; Robin Walters; Daniel Avery; Ruth Boxall; Yumei Chang; Yiping Chen; Zhengming Chen; Robert Clarke; Huaidong Du; Simon Gilbert; Alex Hacker; Mike Hill; Michael Holmes; Andri Iona; Christiana Kartsonaki; Rene Kerosi; Ling Kong; Om Kurmi; Garry Lancaster; Sarah Lewington; Kuang Lin; John McDonnell; Iona Millwood; Qunhua Nie; Jayakrishnan Radhakrishnan; Paul Ryder; Sam Sansome; Dan Schmidt; Paul Sherliker; Rajani Sohoni; Becky Stevens; Iain Turnbull; Robin Walters; Jenny Wang; Lin Wang; Neil Wright; Ling Yang; Xiaoming Yang; Zheng Bian; Yu Guo; Xiao Han; Can Hou; Jun Lv; Pei Pei; Chao Liu; Yunlong Tan; Canqing Yu; Zengchang Pang; Ruqin Gao; Shanpeng Li; Shaojie Wang; Yongmei Liu; Ranran Du; Yajing Zang; Liang Cheng; Xiaocao Tian; Hua Zhang; Yaoming Zhai; Feng Ning; Xiaohui Sun; Feifei Li; Silu Lv; Junzheng Wang; Wei Hou; Mingyuan Zeng; Ge Jiang; Xue Zhou; Liqiu Yang; Hui He; Bo Yu; Yanjie Li; Qinai Xu; Quan Kang; Ziyan Guo; Dan Wang; Ximin Hu; Hongmei Wang; Jinyan Chen; Yan Fu; Zhenwang Fu; Xiaohuan Wang; Min Weng; Zhendong Guo; Shukuan Wu; Yilei Li; Huimei Li; Zhifang Fu; Ming Wu; Yonglin Zhou; Jinyi Zhou; Ran Tao; Jie Yang; Jian Su; Fang Liu; Jun Zhang; Yihe Hu; Yan Lu; Liangcai Ma; Aiyu Tang; Shuo Zhang; Jianrong Jin; Jingchao Liu; Zhenzhu Tang; Naying Chen; Ying Huang; Mingqiang Li; Jinhuai Meng; Rong Pan; Qilian Jiang; Jian Lan; Yun Liu; Liuping Wei; Liyuan Zhou; Ningyu Chen; Ping Wang; Fanwen Meng; Yulu Qin; Sisi Wang; Xianping Wu; Ningmei Zhang; Xiaofang Chen; Weiwei Zhou; Guojin Luo; Jianguo Li; Xiaofang Chen; Xunfu Zhong; Jiaqiu Liu; Qiang Sun; Pengfei Ge; Xiaolan Ren; Caixia Dong; Hui Zhang; Enke Mao; Xiaoping Wang; Tao Wang; Xi Zhang; Ding Zhang; Gang Zhou; Shixian Feng; Liang Chang; Lei Fan; Yulian Gao; Tianyou He; Huarong Sun; Pan He; Chen Hu; Xukui Zhang; Huifang Wu; Pan He; Min Yu; Ruying Hu; Hao Wang; Yijian Qian; Chunmei Wang; Kaixu Xie; Lingli Chen; Yidan Zhang; Dongxia Pan; Qijun Gu; Yuelong Huang; Biyun Chen; Li Yin; Huilin Liu; Zhongxi Fu; Qiaohua Xu; Xin Xu; Hao Zhang; Huajun Long; Xianzhi Li; Libo Zhang; Zhe Qiu
    更新日期:2020-01-21
  • Effectiveness of post-partum family planning interventions on contraceptive use and method mix at 1 year after childbirth in Kinshasa, DR Congo (Yam Daabo): a single-blind, cluster-randomised controlled trial
    Lancet Glob. Health (IF 15.873) Pub Date : 2020-01-17
    Nguyen Toan Tran; Armando Seuc; Béatrice Tshikaya; Maurice Mutuale; Sihem Landoulsi; Brigitte Kini; Bernadette Mbu Nkolomonyi; Jean Nyandwe Kyloka; Félicité Langwana; Asa Cuzin-Kihl; James Kiarie; Mary Eluned Gaffield; Rachel Yodi; Désiré Mashinda Kulimba
    更新日期:2020-01-21
  • 2020–30: the decade of anti-corruption?
    Lancet Glob. Health (IF 15.873) Pub Date : 2019-12-05
    The Lancet Global Health

    Universal health coverage (UHC) is a political choice, as WHO Director-General Tedros Adhanom Ghebreyesus is fond of reminding us. Strong leadership and good governance are prerequisites on a country's journey towards a high-quality, efficient, and equitable health system. But a largely unspoken impediment threatens to hinder the health system governance and financing necessary to make UHC a reality: corruption.

    更新日期:2019-12-13
  • Measurement matters: who and what counts on the road to universal health coverage
    Lancet Glob. Health (IF 15.873) Pub Date : 2019-12-11
    Nancy Fullman; Rafael Lozano

    Advancing towards universal health coverage (UHC)—whereby all people receive the health services they need without financial hardship—is viewed as a primary way for countries to improve health and equity.,  Although UHC is often framed as bold yet achievable, questions remain on how best to monitor country-level gains and challenges. To make progress on the ground, we must understand where countries are today—in terms of both service coverage and financial risk protection—and what is needed to bring UHC closer to reality in the future.

    更新日期:2019-12-13
  • Learning from progress: global NCD policy implementation at national level
    Lancet Glob. Health (IF 15.873) Pub Date : 2019-12-05
    Sandeep P Kishore; Usnish B Majumdar

    Non-communicable diseases (NCDs) have begun to receive promising political and social attention from heads of state and ministries of health. Starting in 2011, several high-level UN meetings have generated political declarations, assessments of global progress, and key NCD-related goals for the 2030 Agenda for Sustainable Development. In concert, WHO has presented 18 best-buy national policies that are deemed cost-effective in systematically and equitably reducing NCD mortality and morbidity—including the provision of relevant metrics (ie, survey infrastructure and targets regarding relevant health outcomes), market-oriented interventions (ie, tobacco and alcohol advertising bans), and policies governing access to key medications and counselling (ie, cardiovascular therapies).

    更新日期:2019-12-13
  • Analysing the affordability of the EAT–Lancet diet
    Lancet Glob. Health (IF 15.873) Pub Date : 2020-01-01
    Adam Drewnowski

    Healthy diets from sustainable food systems was the ostensible theme of the EAT–Lancet Commission. The four principal domains of sustainable diets, as defined by the Food and Agriculture Organization of the United Nations in 2010, were health, economics, society, and the environment. Sustainable diets were defined as those that were healthy, affordable, appealing, and environmentally friendly. Sustainable food systems are now defined as those that produce nutrient-rich foods that are affordable, socially and culturally acceptable, and sparing of both natural and human resources. Affordability was, and is, a key component of sustainable diets and of sustainable food systems.

    更新日期:2019-12-13
  • Strengthening quality of care for children who are HEU
    Lancet Glob. Health (IF 15.873) Pub Date : 2019-11-29
    Ameena Goga

    The analysis by Amy Slogrove and colleagues in The Lancet Global Health contributes to increased understanding of the extent of future health needs of children in low-income and middle-income countries (LMICs) with high HIV prevalence. Using 2019 UNAIDS global estimates of children who are HIV-exposed uninfected (HEU) as well as the UN Population Division estimates of the number of all children in each region or country, the authors produced four estimates: the regional or national prevalence of children who were HEU; the regional or national contribution of children who were HEU to the global population of children who were HEU; the proportion of children who were HEU and exposed to antiretroviral drugs; and the percentage change in the global population of children who were HEU between 2000 and 2018.

    更新日期:2019-12-13
  • A call for a systems science approach to understanding drug use in urban environments
    Lancet Glob. Health (IF 15.873) Pub Date : 2020-01-01
    Danielle C Ompad

    In The Lancet Global Health, Lindsey Hines and colleagues quantify the association between injecting drug use and development indicators. The authors found that higher rates of urban population growth were associated with older age at onset of injecting drug use (1·40 years per annual percentage change, 95% CI 0·41–2·40) and lower gross domestic product was associated with a lower median age of people who inject drugs (PWID; 0·13 years per US$1000 GDP increase, 0·06–0·20; p<0·0001) and shorter duration of injecting drug use (0·11 years per $1000 GDP increase, 0·04–0·18; p=0·002). These findings have clear implications for Sustainable Development Goal (SDG) 3, which is aimed at ensuring healthy lives and promoting wellbeing for all at all ages. One of the SDG 3 targets is to strengthen the prevention and treatment of substance abuse. Furthermore, although SDG 11 does not have specific drug use-related targets, these findings also suggest that the urban environment is an important contextual variable for injecting drug use. Moreover, urbanisation is occurring most quickly in low-income and middle-income countries (LMICs); 65·9% of countries with urbanisation rates equal to or higher than the median among urbanising countries (ie, excluding countries that have negative urban growth) in 2015 were also LMICs, suggesting a possible interaction between gross domestic product and urbanisation.

    更新日期:2019-12-13
  • Is ivermectin safe in pregnancy?
    Lancet Glob. Health (IF 15.873) Pub Date : 2020-01-01
    Christopher L King

    Ivermectin is one of the most important antibiotics discovered. It is recognised as a landmark drug by the American Chemical Society and its discoverers received the Nobel Prize in 2015. Additionally, ivermectin is one of the most widely used anti-parasitic drugs for animals and humans. Since 1987, about 3·7 billion treatments have been given worldwide primarily for mass drug administration (MDA) campaigns for onchocerciasis and lymphatic filariasis in sub-Saharan Africa. Ivermectin is also highly effective against strongyloides, scabies, and ticks, and it has recently been shown to be an effective endectocide that kills feeding mosquitoes with the potential to reduce malaria transmission. The use of ivermectin will expand. For example, findings showed that ivermectin combined with diethylcarbamazine and albendazole is more effective than diethylcarbamazine plus albendazole as part of an MDA campaign for the treatment of lymphatic filariasis, resulting in greatly expanded use of ivermectin in MDA programmes worldwide., 

    更新日期:2019-12-13
  • The light of hope: focusing on shigella and ETEC infections
    Lancet Glob. Health (IF 15.873) Pub Date : 2019-11-13
    Karen H Keddy

    “…the light of hope that once burned so brightly has faded as a dream of a summer night.” So commented Kiyoshi Shiga in 1936, regarding his dream of eradicating shigellosis. More than 100 years after Shiga first recognised the role of the eponymous bacterium causing dysentery, Karoun Bagamian and colleagues, in their Article in The Lancet Global Health, have ambitiously modelled crucial features of risk, impact, and sequelae of two important diseases in children younger than 5 years of age—shigellosis and enterotoxigenic Escherichia coli (ETEC) diarrhoea—at a subnational level in 11 eastern and central sub-Saharan African countries. This information has the potential to foster highly focused programmes in addressing disease burdens due to these pathogens and provides a baseline against which programmatic success can be measured.

    更新日期:2019-12-13
  • Challenging the assumption that interpregnancy interval causes stillbirth in low-income and middle-income countries
    Lancet Glob. Health (IF 15.873) Pub Date : 2020-01-01
    Gizachew Assefa Tessema; Gavin Pereira

    Interpregnancy interval, which is the time between the end of one pregnancy and conception of the subsequent pregnancy, is a modifiable risk factor that has the potential to prevent a fraction of stillbirths—particularly in low-income and middle-income countries (LMICs) where 98% of global stillbirths occur. Most of these stillbirths are attributable to poor maternal health and inadequate antenatal and intrapartum care. Several studies have reported associations between stillbirth and interpregnancy interval.,  Whether these associations reflect a causal relationship remains open for discussion, despite the existence of plausible biological pathways. Interpregnancy interval per se cannot be randomly assigned to women directly, so cannot be studied in the gold standard format of a randomised controlled trial. We usually rely on well-designed observational studies to control for confounding of associations with the exposure, which is time. Although the intrinsic temporal nature of the exposure requires careful consideration of bias, it also offers opportunities for causal inference.

    更新日期:2019-12-13
  • Diverging trends in obesity, diabetes, and raised blood pressure in the Americas
    Lancet Glob. Health (IF 15.873) Pub Date : 2020-01-01
    Fernando Lanas; Pamela Seron

    In The Lancet Global Health, the NCD Risk Factor Collaboration—Americas Working Group report the trends in the Americas from 1980 to 2014 of three important cardiometabolic risk factors: obesity, diabetes, and increased blood pressure. The results of this study are important to the Americas because cardiovascular diseases are the main cause of death in almost all countries of the region, stroke and myocardial infarction being the leading causes. The three risk factors addressed in the study are some of those that explained 90% of the population-attributable risk for myocardial infarction in the INTERHEART Latin America study and stroke in the INTERSTROKE study. Additionally, the results of this study are particularly important for Latin American because of the insufficient information available on risk factors trends, other than those published by the NCD Risk Factor Collaboration on obesity, diabetes, and raised blood pressure.,  , 

    更新日期:2019-12-13
  • Vitamin D status in Africa is worse than in other continents
    Lancet Glob. Health (IF 15.873) Pub Date : 2019-11-27
    Roger Bouillon

    Serum concentration of 25-hydroxyvitamin D (25[OH]D) is the best marker for nutritional vitamin D status. Although no consensus has been reached on the optimal 25(OH)D concentration, all guidelines agree that serum 25(OH)D concentrations of less than 30 nmol/L (12 ng/mL) should be avoided in all age groups. Several reviews of vitamin D status have concluded that vitamin D deficiency is highly prevalent around the world, yet Africa is considered to be largely spared from severe vitamin D deficiency.,  A global review of serum 25(OH)D concentrations found that concentrations of less than 30 nmol/L are present in around 7% of the global population. Severe vitamin D deficiency affects around 5% of the US population (based on a representative sample from the National Health and Nutrition Examination Survey 2011–14), 14% of individuals in Europe (based on 11 randomised controlled trials), and a higher percentage of people living in the Middle East or Gulf states. Severe vitamin D deficiency has also been observed in Northern India and China. In The Lancet Global Health, Reagan M Mogire and colleagues describe the vitamin D status of 21 474 individuals living in 23 African countries. Severe vitamin D deficiency (<30 nmol/L 25[OH]D) was found in about 18% of these individuals, suggesting that Africa could be the continent with the highest frequency of severe vitamin D deficiency (). This finding is in contrast with the widely held view that the extensive sunshine in Africa, the cradle of mankind, was indicative for the optimal vitamin D status of early humans. The study by Mogire and colleagues has some major limitations, in that it does not evaluate a representative sample of the African population, does not use accuracy-validated assays, and overrepresents North African countries and South Africa, with no data on many African countries. Nevertheless, the study does improve our global view of vitamin D deficiency.

    更新日期:2019-12-13
  • The economics of medical drones
    Lancet Glob. Health (IF 15.873) Pub Date : 2020-01-01
    Timothy Amukele

    Cargo drones emerged around 2014 as a new way to address the public health needs of victims of natural disasters as well as the approximately 2 billion people living in isolated communities worldwide.,  Yet, despite this massive public health potential, drones have not yet been widely adopted as a means of cargo transportation by hospitals, clinics, and other stakeholders in hard-to-reach places around the world. There are many reasons for the lack of adoption, but perhaps the most important is that the costs of acquiring and operating drones is unknown.

    更新日期:2019-12-13
  • Advancing research ethics systems in Latin America and the Caribbean: a path for other LMICs?
    Lancet Glob. Health (IF 15.873) Pub Date : 2020-01-01
    Marcie Neil; Carla Saenz

    Low-income and middle-income countries (LMICs) need to do research to achieve improvements in public health, which comes with the imperative to do research ethically. Countries in Latin America and the Caribbean have continuously strengthened their capacities to advance ethical research over the past few decades, though challenges remain in ensuring that all research is ethical.

    更新日期:2019-12-13
  • Challenges in ensuring robust research and reporting of health outcomes in sub-Saharan African prisons
    Lancet Glob. Health (IF 15.873) Pub Date : 2020-01-01
    Rosemary Mhlanga-Gunda; Nthabeleng Motsomi-Moshoeshoe; Emma Plugge; Marie Claire Van Hout

    The global prison population has continued to rise, with almost 11 million people in prison despite downward trends in crime. The Standard Minimum Rules for the Treatment of Prisoners mandates the protection of basic human rights for persons deprived of liberty and advocates for the improvement of living conditions and environments of people in prison. Health disparity is evident with imprisoned people likely to be the most marginalised and poorest members of society, with health outcomes further compounded when incarcerated. Tackling health inequalities by addressing the health needs of people in prisons is therefore an essential component of contributing to the achievement of the Sustainable Development Goals specifically to reduce inequality within and among countries and leaving no one behind. Ensuring effective delivery of health care in prisons is an important aspect of life in prison, often challenging given the huge burden of disease in this key population, and is vital in terms of connecting prison health to public health. Imprisoned people are however significantly under-represented in health research, which underpins a lack of evidence-based interventions addressing their complex health needs or informing wider reform of the health service in prisos.,  Whilst a global increase in prison health research has been observed, this rise is uneven and concentrated in high-income countries.

    更新日期:2019-12-13
  • World RePORT: a database for mapping biomedical research funding
    Lancet Glob. Health (IF 15.873) Pub Date : 2020-01-01
    Taghreed Adam; Hannah Akuffo; James G Carter; Zach Charat; Michael J Cheetham; Aldo Crisafulli; Cindy M Danielson; Jennifer Gunning; Brian Haugen; Dominika Jajkowicz; Simon Kay; Peter H Kilmarx; Julia Mólto López; Ole F Olesen; Inmaculada Peñas-Jiménez; Kedest Tesfagiorgis; Stacy K Wallick; Roger I Glass
    更新日期:2019-12-13
  • 更新日期:2019-12-13
  • Births and deaths must be registered in Africa
    Lancet Glob. Health (IF 15.873) Pub Date : 2020-01-01
    Osman Sankoh; Kim Eva Dickson; Sanjo Faniran; John Idris Lahai; Fatu Forna; Evans Liyosi; Mohamed Koblo Kamara; Sonnia-Magba Bu-Buakei Jabbi; Andrew Bob Johnny; Neneh Conteh-Khali; Agnes Bangali; Jia Bainga Kangbai; Tahir Bockarie; Mohamed M Massaquoi; Francis Smart; Amara Jambai; Michael Clarke; Andile Dlamini; Pali Lehohla; Mark Weston

    Goal 3 of the Sustainable Development Goals (SDGs) aims to “ensure healthy lives and promote well-being for all at all ages” by 2030. The goal includes targets related to reducing maternal and child mortality, ending lethal epidemics such as HIV/AIDS and malaria, reducing mortality from non-communicable diseases, and curbing the number of deaths caused by traffic accidents and environmental contamination. SDG 16, which aims to build peaceful, just, and inclusive societies, includes a target to reduce the number of deaths caused by violence.

    更新日期:2019-12-13
  • Improving birth and death data for African decision making
    Lancet Glob. Health (IF 15.873) Pub Date : 2020-01-01
    John Nkengasong; Eduardo Gudo; Ivalda Macicame; Xadreque Maunze; Agbessi Amouzou; Kathryn Banke; Scott Dowell; Ilesh Jani

    The scarcity of current, complete, and accurate primary data on causes of death in most of sub-Saharan Africa restricts the ability of countries to measure progress against many of the Sustainable Development Goal targets, measure the impact of programmatic interventions, prioritise and plan to address their health needs, and achieve the goals of the Africa Agenda 2063. On Aug 10, 2018, the first African Civil Registration and Vital Statistics (CRVS) Day was celebrated, underscoring the importance of working towards compulsory, universal CRVS systems across the continent. However, progress towards establishing these systems has been slow; even with substantial inputs and political will, universal CRVS will probably take decades to be functional in all countries.

    更新日期:2019-12-13
  • Correction to: Exposure to improved nutrition from conception to age 2 years and adult cardiometabolic disease risk: misclassification of 31 individuals
    Lancet Glob. Health (IF 15.873) Pub Date : 2020-01-01
    Nicole D Ford; Jere R Behrman; John F Hoddinott; John A Maluccio; Reynaldo Martorell; Manuel Ramirez-Zea; Aryeh D Stein

    The Institute of Nutrition of Central America and Panama (INCAP) cohort participated in a nutrition intervention as children from 1969 to 1977 in Guatemala and has been followed up prospectively to assess the effect of improved nutrition on a range of growth, health, and development outcomes. We reported previously that exposure to improved protein-energy nutrition from conception to the second birthday was associated with reduced odds of diabetes and increased risk of obesity and several obesity-related conditions.

    更新日期:2019-12-13
  • Correction to Lancet Glob Health 2018; 6: e875–84
    Lancet Glob. Health (IF 15.873) Pub Date : 2020-01-01

    Ford ND, Behrman JR, Hoddinott JF, et al. Exposure to improved nutrition from conception to age 2 years and adult cardiometabolic disease risk: a modelling study. Lancet Glob Health 2018; 6: e875–84—In this Article, an error in the analytic data set was identified, which meant that some estimates presented in the paper were incorrect. The authors have written a Correspondence explaining these errors and the data in the Article have been corrected. These corrections have been made as of Dec 12, 2019.

    更新日期:2019-12-13
  • Correction to Lancet Glob Health 2019; 7: e1482–83
    Lancet Glob. Health (IF 15.873) Pub Date : 2019-10-22

    Allen LN, Hatefi A, Feigl AB. Corporate profits versus spending on non-communicable disease prevention: an unhealthy balance. Lancet Glob Health 2019; 7: e1482–83—In this Comment, the affiliation and email address of the corresponding author were incorrect. These corrections have been made as of Oct 22, 2019.

    更新日期:2019-12-13
  • Correction to Lancet Glob Health 2019; 7: e1585–86
    Lancet Glob. Health (IF 15.873) Pub Date : 2020-01-01

    Kadir A, Martinez Garcia D, Romero F. New ways to measure the effects of armed conflict in civilian population. Lancet Glob Health 2019; 7: 1585–86—In this Comment, the affiliation for Daniel Martinez Garcia and Florencia Romero was incorrect; the correct affiliation should be Médecins Sans Frontières, Geneva, Switzerland. This correction has been made as of Dec 12, 2019.

    更新日期:2019-12-13
  • Correction to Lancet Glob Health 2019; 7: e1609–11
    Lancet Glob. Health (IF 15.873) Pub Date : 2019-11-13

    Newton PN, Bond KC, on behalf of the Oxford Statement signatories. Global access to quality-assured medical products: the Oxford Statement and call to action. Lancet Glob Health; 2019; 7: e1609–11—In this Comment, the URL for the short Oxford Statement should have been “https://www.iddo.org/news/mqph-short-statement-2018”. Additionally, some of the signatories were missing from appendix 3. These corrections have been made, and a new French translation added as Appendix 1, as of Nov 13, 2019.

    更新日期:2019-12-13
  • 更新日期:2019-12-13
  • Implementation of non-communicable disease policies: a geopolitical analysis of 151 countries
    Lancet Glob. Health (IF 15.873) Pub Date : 2019-12-05
    Luke N Allen; Brian D Nicholson; Beatrice Y T Yeung; Francisco Goiana-da-Silva
    更新日期:2019-12-13
  • Affordability of the EAT–Lancet reference diet: a global analysis
    Lancet Glob. Health (IF 15.873) Pub Date : 2019-11-07
    Kalle Hirvonen; Yan Bai; Derek Headey; William A Masters
    更新日期:2019-12-13
  • Estimates of the global population of children who are HIV-exposed and uninfected, 2000–18: a modelling study
    Lancet Glob. Health (IF 15.873) Pub Date : 2019-11-29
    Amy L Slogrove; Kathleen M Powis; Leigh F Johnson; John Stover; Mary Mahy
    更新日期:2019-12-13
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