样式: 排序: IF: - GO 导出 标记为已读
-
‘We no longer experience the same pain’: a cross-sectional study assessing the impact of Heart and Sole Africa's podoconiosis prevention education program Trans. Roy. Soc. Trop. Med. Hyg. (IF 2.2) Pub Date : 2024-03-11 Agazi Fitsum Gebreselassie, Natnael Shimelash, Ahamed Kallon, George Mkondo, Tonya Huston, Janna M Schurer
Background Podoconiosis is a non-infectious neglected tropical disease caused by long-term exposure to irritant volcanic soils. It results in severe physical, psychological and financial consequences. Heart and Sole Africa (HASA) is a non-governmental, community-based organization providing management to podoconiosis patients in Rwanda. We sought to analyze the impact of their program on the lives
-
‘My feet cannot stand on their own’: podoconiosis patient healthcare expenditures and income impacts in Rwanda Trans. Roy. Soc. Trop. Med. Hyg. (IF 2.2) Pub Date : 2024-03-08 Janna M Schurer, Ursin Bayisenge, Dieudonne Hakizimana, Ellen Rafferty
Background Podoconiosis is a progressive and debilitating form of tropical lymphoedema endemic to Rwanda. Although the physical and psychological consequences are well known, few studies have evaluated the financial burden of podoconiosis. Methods This cross-sectional, quantitative study aimed to characterize direct treatment costs and impacts on annual earnings among individuals living with podoconiosis
-
Exploring the latency period in Chagas disease: duration and determinants in a cohort from Colombia Trans. Roy. Soc. Trop. Med. Hyg. (IF 2.2) Pub Date : 2024-02-27 Mario Javier Olivera, Lyda Muñoz
Background Chagas disease has a varying latency period, the time between infection and onset of cardiac symptoms, due to multiple factors. This study seeks to identify and understand these factors to enhance our knowledge of the disease. Methods A retrospective follow-up study was conducted in Colombia on patients with indeterminate chronic Chagas disease. Medical files were examined to evaluate the
-
Lessons from the field: compound-specific management in acute pesticide poisoning Trans. Roy. Soc. Trop. Med. Hyg. (IF 2.2) Pub Date : 2024-02-10 Vasundhara R Verma, Thomas Lamb, Md Abdus Sattar, Aniruddha Ghose, Michael Eddleston
Pesticide poisoning is a common medical emergency in the rural tropics, with significant associated mortality. Pesticide poisoning is an umbrella term that encompasses a wide variety of substances with differing clinical toxidromes and outcomes. Despite this, confirmation of the specific compound ingested is rarely performed. In this Lessons from the Field, we argue that pesticide-specific management
-
Prevalence of delayed initiation of rabies postexposure prophylaxis and factors influencing it among animal bite victims from Eastern Uttar Pradesh, India Trans. Roy. Soc. Trop. Med. Hyg. (IF 2.2) Pub Date : 2024-02-07 Imran Ahmed Khan, MD Abu Bashar, Sufiya Mohsin, D K Shrivastava
Background In a rabies-endemic country like India, every animal bite is potentially taken as rabid exposure and timely and appropriate postexposure prophylaxis (PEP) is crucial as rabies is an almost 100% fatal disease. Methods A retrospective record-based study was conducted at an anti-rabies clinic (ARC) in Eastern Uttar Pradesh, India. Data of the animal bite victims attending the ARC for PEP from
-
COVID-19 vaccination during pregnancy and adverse perinatal outcomes: a systematic review and meta-analysis Trans. Roy. Soc. Trop. Med. Hyg. (IF 2.2) Pub Date : 2024-01-31 Jia Wang, Yuzhi Deng, Weijing Wang
We aimed to estimate the associations between coronavirus disease 2019 (COVID-19) vaccination during pregnancy and the risks of adverse perinatal outcomes. We performed a literature search in PubMed, Web of Science and Embase to identify eligible studies published up to 24 September 2023, yielding 39 included studies. Pooled relative risks (RRs) with 95% confidence intervals (CIs) were calculated with
-
The Centenary of the Leprosy Relief Association (Lepra)—a moment for celebration and reflection Trans. Roy. Soc. Trop. Med. Hyg. (IF 2.2) Pub Date : 2024-01-25 Irene Allen, Diana N Lockwood, Roderick J Hay
The year 2024 is the Centenary of the foundation of the Leprosy Relief Association (Lepra), formerly the British Empire Leprosy Relief Association (BELRA). The name of the organization changed to the LEProsy Relief Association (LEPRA) in 1976 but has been known as Lepra since 2008. Over the years it has worked closely with members and office holders of the Royal Society of Tropical Medicine and Hygiene
-
The seroprevalence of toxocariasis and related risk factors in children in Ho Chi Minh City, Vietnam: results from a school-based cross-sectional study Trans. Roy. Soc. Trop. Med. Hyg. (IF 2.2) Pub Date : 2024-01-23 Thieu V Ha, Tien T N Vo, Duy K H Dang, Y M L Tran, Thanh V Kim, Duc H Le, Lan-Anh T Do, Hong K Tang
Background Children are especially vulnerable to Toxocara infection and its severe complications; however, there have not been any published data on the disease prevalence and treatment effectiveness in the population of Vietnamese children. This study was conducted to determine the prevalence of toxocariasis and explore factors associated with Toxocara infection in children aged 3–15 y in Ho Chi Minh
-
Temporal trends and spatial and spatiotemporal distribution of schistosomiasis mansoni in northeast Brazil between 2005 and 2016 Trans. Roy. Soc. Trop. Med. Hyg. (IF 2.2) Pub Date : 2024-01-20 Vitória Jordana Bezerra Alencar, Pedro Dantas Lima, João Paulo Vieira Machado, Maria Wilma da Silva Lima, Sheilla da Conceição Gomes, Wandklebson Silva da Paz, Rosália Elen Santos Ramos, Letícia Pereira Bezerra, Israel Gomes de Amorim Santos
Background Schistosoma mansoni is a parasitic disease of great magnitude for Brazilian public health. We aimed to analyse the temporal trend and spatial and spatiotemporal distribution of positivity rates for schistosomiasis mansoni in northeast Brazil. Methods This is a descriptive study with an ecological approach, carried out between 2005 and 2016. We calculated the positivity rate for the disease
-
Phylogenetic analysis of Acanthamoeba isolated from soil samples and nasal cavities of patients with malignancy: a public health concern in the northwest of Iran Trans. Roy. Soc. Trop. Med. Hyg. (IF 2.2) Pub Date : 2024-01-19 Ali Pezeshki, Shadi Tajic, Parvin Farahmandian, Ali Haniloo, Abbas Mahmmodzadeh, Maryam Niyyati, Hamed Behniafar
Background The genus Acanthamoeba is reported from various environmental sources and can cause multiple complications, including chronic amoebic aeratitis and amoebic granulomatous encephalitis. This study investigated the presence and genotyping of Acanthamoeba in the soil of parks and patients with malignancies referred to health centers in Zanjan city, Iran. Methods In this cross-sectional study
-
Seroprevalence of dengue and chikungunya viruses among urban refugees in Klang Valley, Malaysia Trans. Roy. Soc. Trop. Med. Hyg. (IF 2.2) Pub Date : 2024-01-16 Norhidayu Sahimin, Zhao Xuan Low, Pouya Hassandarvish, Izzah Ruzana Mohd Hanapi, Siti Nursheena Mohd Zain, Hasmawati Yahaya, Sazaly Abu Bakar
Background Mosquito-borne diseases pose a significant global public health threat, with Malaysia's Klang Valley experiencing numerous outbreaks in densely populated urban areas. Methods This study aimed to estimate the seroprevalence of anti-dengue and anti-chikungunya antibodies among urban refugees in the Klang Valley, Malaysia, and identify associated risk factors. Results High seroprevalence of
-
Molecular monitoring of treatment efficacy in human visceral leishmaniasis Trans. Roy. Soc. Trop. Med. Hyg. (IF 2.2) Pub Date : 2024-01-15 Sutopa Roy, Srija Moulik, Surya Jyati Chaudhuri, Manab K Ghosh, R P Goswami, Bibhuti Saha, Mitali Chatterjee
Background Focused efforts of the visceral leishmaniasis elimination program have led to a drastic decline in cases, and the present challenge is disease monitoring, which this study aimed to assess. Methods A Leishmania kinetoplastid-targeted qPCR quantified parasite load at disease presentation, and following treatment completion (n=49); an additional 80 cases were monitored after completion of treatment
-
Mycetoma in Ecuador Trans. Roy. Soc. Trop. Med. Hyg. (IF 2.2) Pub Date : 2024-01-12 David J Chandler, Luis Escalante, Astrid Maldonado, Sonia Tello, Shirley Orellana, Edgar Escalante
Background Previous studies on the distribution of mycetoma globally have failed to identify Ecuador as an endemic country. Methods We present data on 35 cases of mycetoma in Ecuador between 1955 and 2021: 5 cases from our experience and 30 cases from the literature. Results Eight cases of eumycetoma (23%) and 27 cases of actinomycetoma (77%) were diagnosed. Most cases originated from the coastal region
-
Scrub typhus in Indonesia: A cross-sectional analysis of archived fever studies samples Trans. Roy. Soc. Trop. Med. Hyg. (IF 2.2) Pub Date : 2024-01-11 Kartika Saraswati, Ampai Tanganuchitcharnchai, Sirada Ongchaikupt, Mavuto Mukaka, Nicholas P J Day, J Kevin Baird, Ungke Antonjaya, Khin S A Myint, Yora P Dewi, Frilasita A Yudhaputri, Sotianingsih Haryanto, N P Diah Witari, Stuart D Blacksell
Background Scrub typhus is an understudied vector-borne bacterial infection. Methods We tested archived fever samples for scrub typhus seropositivity to begin charting its geographic distribution in Indonesia. We analysed 1033 serum samples from three sites. IgM and IgG enzyme-linked immunosorbent assay (ELISA) against Orientia tsutsugamushi was performed using Karp, Kato, Gilliam, TA 716 antigens
-
Knowledge and approach towards Helicobacter pylori diagnosis and management among primary care physicians in Cameroon: a cross-sectional study Trans. Roy. Soc. Trop. Med. Hyg. (IF 2.2) Pub Date : 2024-01-04 Nkengeh Tazinkeng, Joao Filipe Monteiro, Bill-Erich Mbianyor, Avis Anya Nowbuth, Monela Ntonifor, Claudia Evenge, Alick Nkhoma, Steven F Moss, Akwi W Asombang
Background Low- and middle-income countries have a high prevalence of Helicobacter pylori infection (HPI). In Cameroon, the majority of HPIs are diagnosed and treated by primary care physicians (PCPs). We sought to assess the knowledge and practices of PCPs in the diagnosis and management of HPI in Cameroon. Methods A hospital-based cross-sectional study was carried out in four randomly selected regions
-
Prevalence of Cryptosporidium and microsporidial infection in HIV-infected individuals Trans. Roy. Soc. Trop. Med. Hyg. (IF 2.2) Pub Date : 2023-12-23 Hasan Didarlu, Mahmoud Mahami-Oskouei, Mojtaba Varshochi, Kareem Hatam-Nahavandi, Firooz Shahrivar, Saeed Bahadory, Aleksandra Barac, Ehsan Ahmadpour
Background Microsporidia and Cryptosporidium are obligate intracellular protozoa. These medically important species are recognized as opportunistic organisms in intestinal complications in human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome patients. Methods The current cross-sectional study was designed and conducted from August 2016 to August 2017 to determine intestinal Cryptosporidium
-
Clinical characteristics of snakebite patients attending a tertiary hospital in Hangzhou, southeast China Trans. Roy. Soc. Trop. Med. Hyg. (IF 2.2) Pub Date : 2023-12-11 Yuchen Shen, Sipin Hu, Shuhua Bao, Mengyun Tu
Background Venomous snakebite is a neglected yet an important public health problem in China, and few studies have focused on them so far. The aim of this study is to investigate clinical characteristics of snakebites patients in a tertiary hospital in Hangzhou, southeast China. Methods A total of 416 snakebite cases were included in this retrospective study. The data were collected from the medical
-
Epidemiological survey, molecular profiling and phylogenetic analysis of cutaneous leishmaniasis in Khyber Pakhtunkhwa, Pakistan Trans. Roy. Soc. Trop. Med. Hyg. (IF 2.2) Pub Date : 2023-12-07 Wasia Ullah, Adil Khan, Sadaf Niaz, Maged A Al-Garadi, Nasreen Nasreen, Ayman A Swelum, Mourad Ben Said
Background Cutaneous leishmaniasis (CL), an emerging vector-borne ailment in Khyber Pakhtunkhwa (KPK), Pakistan, exhibits diverse spread patterns and outbreaks. Methods To comprehend its epidemiology and identify parasite species, we conducted an active survey on suspected CL cases (n=8845) in KPK. Results Microscopy and internal transcribed spacer-1 PCR–restriction fragment length polymorphism (RFLP)
-
Impact of lamivudine treatment in late pregnancy on the development of the foetal immune response to hepatitis B virus: a meta-analysis in R with the metafor package Trans. Roy. Soc. Trop. Med. Hyg. (IF 2.2) Pub Date : 2023-12-04 Peng Zhao, Ying Zhao, Minmin Du, Xiuying Chen, Yongchao Lu
Background Hepatitis B virus (HBV) infection is a worldwide public health burden, especially in Asia and Africa. Concerns were raised that foetal exposure to HBV and antiretroviral therapy (ART) might suppress the innate immune response and reduce the production of hepatitis B surface antibody (HBsAb) in foetuses and infants. We therefore conducted the current study to evaluate the impact of ART on
-
National health insurance scheme improves access and optimization of antimicrobial use in the Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Nigeria Trans. Roy. Soc. Trop. Med. Hyg. (IF 2.2) Pub Date : 2023-11-28 Temitope O Obadare, Taiwo O Ogundipe, Adeyemi T Adeyemo, Caleb M Aboderin, Doyin R Abiola, Naheemot O Sule, Aaron O Aboderin
Background Nigeria instituted the National Health Insurance Scheme (NHIS) for universal health coverage. This study compared the NHIS and out-of-pocket (OOP) antibiotic prescribing with the World Health Organization (WHO) optimal values. Methods A total of 2190 prescription forms from the NHIS and OOP were included in this study conducted at Obafemi Awolowo University Teaching Hospitals Complex, Nigeria
-
Newly detected paediatric melioidosis cases in a single referral children's hospital in Ho Chi Minh City indicate the probable underrecognition of melioidosis in South Vietnam Trans. Roy. Soc. Trop. Med. Hyg. (IF 2.2) Pub Date : 2023-11-24 Thai Son Pham, Elisabeth König, The Trung Bui, Thi Ngoc Anh Vu, Tran Nam Nguyen, Chau Viet Do, Sabine Lichtenegger, Nguyen Hai Linh Bui, Huu Tung Trinh, Ivo Steinmetz, Thanh Trung Trinh
Background The epidemiology of melioidosis in Vietnam, a disease caused by the soil bacterium Burkholderia pseudomallei, remains unclear. This study aimed to detect paediatric melioidosis in South Vietnam and describe clinical features and the geographic distribution. Methods We introduced a simple laboratory algorithm for detecting B. pseudomallei from clinical samples at Children's Hospital 2 in
-
An intervention study investigating the effectiveness of contextualizing multimodal strategy on improving hand hygiene at a tertiary hospital in Nigeria. Trans. Roy. Soc. Trop. Med. Hyg. (IF 2.2) Pub Date : 2023-11-23 Yahaya Yaqub,Zainab Lamido Tanko,Aliyu Aminu,Usman Yahya Umar,Joan Ejembi
BACKGROUND Hand hygiene (HH) is a proven low-cost means to curtail the problem of hospital-acquired infection (HAI). However, a low HH compliance rate of 17.1% was found among surgical health workers at Ahmadu Bello University Teaching Hospital (ABUTH) in Zaria, Nigeria. METHODS This was an intervention study conducted utilizing mixed methods to investigate the effectiveness of the World Health Organization
-
Scrub typhus in Northeast India: epidemiology, clinical presentations, and diagnostic approaches Trans. Roy. Soc. Trop. Med. Hyg. (IF 2.2) Pub Date : 2023-11-17 Beyau M Konyak, Monika Soni, Shyamalima Saikia, Tochi Chang, Indrani Gogoi, Ibakmensi Khongstid, Chung-Ming Chang, Mohan Sharma, Ramendra Pati Pandey
Scrub typhus is one of the most neglected tropical diseases, a leading cause of acute undifferentiated febrile illness in areas of the ‘tsutsugamushi triangle’, diagnosed frequently in South Asian countries. The bacteria Orientia tsutsugamushi is the causative agent of the disease, which enters the human body through the bite of trombiculid mites (also known as chiggers) of the genus Leptotrombidium
-
Patterns of individual compliance with anthelmintic treatment for soil-transmitted helminth infections in southern Ethiopia over six rounds of community-wide mass drug administration. Trans. Roy. Soc. Trop. Med. Hyg. (IF 2.2) Pub Date : 2023-11-15 R Maddren,B Collyer,A E Phillips,S Rayment Gomez,B Abtew,U Anjulo,D Tadele,A Sharma,A Tamiru,E Firdawek,M Chernet,R M Anderson
BACKGROUND The mainstay of soil-transmitted helminth (STH) control is repeated mass drug administration (MDA) of anthelmintics to endemic populations. Individual longitudinal compliance treatment patterns are important for identifying pockets of infected individuals who remain untreated and serve as infection reservoirs. METHODS The Geshiyaro Project censused the study population in Wolaita, Ethiopia
-
Cost-effectiveness of One Health interventions for rabies elimination: a systematic review. Trans. Roy. Soc. Trop. Med. Hyg. (IF 2.2) Pub Date : 2023-10-30 Zinia T Nujum,Miqdad Asaria,Karishma Krishna Kurup,Malathi Mini,Sumit Mazumdar,Monal Daptardar,Harish Tiwari
The 'One Health' (OH) approach is the most promising idea in realising the global goal of eliminating canine-mediated human rabies by 2030. However, taking an OH approach to rabies elimination can mean many different things to different people. We conducted a systematic review scrutinizing economic evaluations (EEs) retrieved from MEDLINE OVID, Embase OVID, Global Health OVID, CINAHL EBSCO and ECONLIT
-
Syndecan-1 levels predict septic shock in critically ill patients with COVID-19. Trans. Roy. Soc. Trop. Med. Hyg. (IF 2.2) Pub Date : 2023-10-28 Nilcyeli Linhares Aragão,Marza de Sousa Zaranza,Gdayllon Cavalcante Meneses,Ana Paula Pires Lázaro,Álvaro Rolim Guimarães,Alice Maria Costa Martins,Natalia Linhares Ponte Aragão,Andrea Mazza Beliero,Geraldo Bezerra da Silva Júnior,Sandra Mara Brasileiro Mota,Polianna Lemos Moura Moreira Albuquerque,Elizabeth De Francesco Daher,Veralice Meireles Sales De Bruin,Pedro Felipe Carvalhedo de Bruin
BACKGROUND The clinical picture of coronavirus disease 2019 (COVID-19)-associated sepsis is similar to that of sepsis of other aetiologies. The present study aims to analyse the role of syndecan-1 (SDC-1) as a potential predictor of septic shock in critically ill patients with COVID-19. METHODS This is a prospective study of 86 critically ill patients due to COVID-19 infection. Patients were followed
-
Using the AS04C-adjuvanted hepatitis B vaccine in patients classified as non-responders. Trans. Roy. Soc. Trop. Med. Hyg. (IF 2.2) Pub Date : 2023-10-28 Sara Fernández Sánchez-Escalonilla,Jesus Gonzalez-Rubio,Alberto Najera,Jose Miguel Cantero Escribano,Francisco Jesús Molina Cabrero,Jesús García Guerrero
BACKGROUND Chronic hepatitis B (HB) remains a significant global health concern, despite the widespread availability of the HB vaccine. While the standard vaccine demonstrates an impressive serological response rate exceeding 90%, a subset of individuals exhibit suboptimal immunity. This study aims to elucidate the efficacy of the AS04C-adjuvanted HB vaccine in addressing non-responsiveness. METHODS
-
The spectrum of central nervous system manifestations in leprosy: a systematic review of published case reports and case series Trans. Roy. Soc. Trop. Med. Hyg. (IF 2.2) Pub Date : 2023-10-18 Ravindra Kumar Garg, Ravi Uniyal, Shweta Pandey, Nidhi Tejan, Imran Rizvi, Praveen Kumar Sharma, Neeraj Kumar, Hardeep Singh Malhotra
Background This systematic review aimed to investigate central nervous system (CNS) involvement in leprosy by analysing multiple cohort studies, individual cases and case series. Methods The Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines were followed. PubMed, Scopus and Embase databases were searched up to 8 July 2023, using a predefined search strategy. Inclusion criteria
-
-
Evaluating the sensitivity and specificity of Determine™ HIV-1/2 rapid test using a 0.01M phosphate-buffered saline produced at the Medical Research Council Unit The Gambia for the diagnosis of HIV Trans. Roy. Soc. Trop. Med. Hyg. (IF 2.2) Pub Date : 2023-10-11 Anna Boté-Casamitjana, Tisbeh Faye-Joof, Ousman Bah, Sira Jallow, Alagie Camara, Olimatou Jallow, Nuredin Mohammed, Karen Forrest, Behzad Nadjm
Background Human immunodeficiency virus (HIV) rapid diagnostic tests (RDTs) are widely used. However, buffer stockouts commonly lead to utilising non-approved liquids, resulting in errors. Our aim was to evaluate the diagnostic accuracy of an alternative buffer. Methods Paired Determine HIV-1/2 rapid tests with commercial buffer and locally produced 0.01M phosphate-buffered saline (PBS) were performed
-
Presidential address: The role of non-governmental organisations in neglected tropical disease programmes. Trans. Roy. Soc. Trop. Med. Hyg. (IF 2.2) Pub Date : 2023-10-03 Simon Bush
-
Primary healthcare service delivery for older people with progressive multimorbidity in low- and middle-income countries: a systematic review Trans. Roy. Soc. Trop. Med. Hyg. (IF 2.2) Pub Date : 2023-10-02 Duncan Kwaitana, Felix Chisoni, Dorothee van Breevoort, Thomas Mildestvedt, Eivind Meland, Jane Bates, Eric Umar
Ensuring primary healthcare (PHC) accessibility to older people with multimorbidity is vital in preventing unnecessary health deterioration. However, older people ≥50 y of age in low- and middle-income countries (LMICs) face challenges in effectively accessing and utilizing PHC. A systematic review was conducted adopting the Andersen–Newman theoretical framework for health services utilization to assess
-
Artesunate-mefloquine therapy for uncomplicated Plasmodium falciparum malaria: an updated systematic review and meta-analysis of efficacy and safety. Trans. Roy. Soc. Trop. Med. Hyg. (IF 2.2) Pub Date : 2023-09-29 Beatriz Sales de Freitas,Gabriel Haiek Fernandes,Ana Carolina Esteves da Silva Pereira,Henry Maia Peixoto
To provide a continuous update on the safety and efficacy of artesunate-mefloquine (ASMQ) compared with other artemisinin combination therapy (ACT) schemes used in the treatment of uncomplicated malaria caused by Plasmodium falciparum, this study updated and expanded the results of the systematic literature review published in 2016. Only randomised controlled clinical trials published from 1 January
-
Snakebites epidemiology in Mexico: a 13-year ecological analysis Trans. Roy. Soc. Trop. Med. Hyg. (IF 2.2) Pub Date : 2023-09-25 Ricardo Méndez-Molina, Ailed Karola Villela-Oriza, Andrea Ariadne Espinosa-Couoh, Oswaldo Huchim-Lara
Background Globally, snakebites have a significant impact on public health and represent substantial costs for health services. Their severity is particularly relevant in developing countries due to the lack of resources and accessibility to health facilities. Additionally, the number of cases may be underestimated, highlighting the urgent need for improved prevention measures. Methods An observational
-
The high burden of pediatric cystic echinococcosis in Kazakhstan: epidemiological and clinical consequences. Trans. Roy. Soc. Trop. Med. Hyg. (IF 2.2) Pub Date : 2023-09-18 Gaukhar Doszhanova,Agnese Colpani,Amangul Duisenova,Andrea De Vito,Zhamilya Zholdybay,Konrad Juszkiewicz,Enrico Brunetti,Adyl Katarbayev,Shokan Kaniyev,Zhanar Zhakenova,Tommaso Manciulli,Aigerim Mustapayeva
BACKGROUND Cystic echinococcosis (CE) is attributable to Echinococcus granulosus metacestodes. Ultrasound examinations enable a stage-specific approach to CE management. However, this approach is not often applied in endemic areas, which include Kazakhstan. METHODS We collected clinical and ultrasound data on CE pediatric patients seen at a national referral surgical center in Almaty, Kazakhstan, during
-
Prevalence of acute kidney injury among dengue cases: a systematic review and meta-analysis. Trans. Roy. Soc. Trop. Med. Hyg. (IF 2.2) Pub Date : 2023-09-13 Ganesh Bushi,Muhammed Shabil,Bijaya Kumar Padhi,Mohammed Ahmed,Pratima Pandey,Prakasini Satapathy,Sarvesh Rustagi,Keerti Bhusan Pradhan,Zahraa Haleem Al-Qaim,Ranjit Sah
Numerous studies have shown a correlation between dengue virus (DENV) infection and kidney disease. However, there is no existing meta-analysis on the prevalence of kidney diseases in the dengue population. A thorough systematic review and meta-analysis were undertaken to determine the prevalence of renal problems in people with DENV infection in order to fill this knowledge gap. A rigorous electronic
-
A Bayesian spatiotemporal approach to modelling arboviral diseases in Mexico. Trans. Roy. Soc. Trop. Med. Hyg. (IF 2.2) Pub Date : 2023-09-08 Moeen Hamid Bukhari,Muhammad Yousaf Shad,Uyen-Sa D T Nguyen,Jesús A Treviño C,Woojin Jung,Waheed U Bajwa,Ana Lucía Gallego-Hernández,Renee Robinson,Nadia Sarai Corral-Frías,Gabriel L Hamer,Penghua Wang,Esther Annan,Chaelin K Ra,David Keellings,Ubydul Haque
BACKGROUND The objective of this study was to evaluate the spatial and temporal patterns of disease prevalence clusters of dengue (DENV), chikungunya (CHIKV) and Zika (ZIKV) virus and how socio-economic and climatic variables simultaneously influence the risk and rate of occurrence of infection in Mexico. METHODS To determine the spatiotemporal clustering and the effect of climatic and socio-economic
-
No secondary impact of ivermectin mass drug administration for onchocerciasis elimination on the prevalence of scabies in northwestern Ethiopia Trans. Roy. Soc. Trop. Med. Hyg. (IF 2.2) Pub Date : 2023-09-04 Robel Yirgu, Jo Middleton, Abebaw Fekadu, Gail Davey, Stephen Bremner, Christopher Iain Jones, Jackie A Cassell
Background Mass drug administration (MDA) is among the five major strategies that are currently in use to control, eliminate or eradicate Neglected Tropical Diseases (NTDs). Optimising MDA to control multiple NTDs maximises impact. The objective of this study is to estimate the secondary impact of ivermectin MDA for onchocerciasis on the prevalence of scabies. Methods This quasi-experimental study
-
A tale of 141 municipalities: the spatial distribution of dengue in Mato Grosso, Brazil Trans. Roy. Soc. Trop. Med. Hyg. (IF 2.2) Pub Date : 2023-09-04 Keli Aparecida Paludo Fernandes, Ariel Rocha de Almeida Filho, Taynná Vacaro Moura Alves, Christine Steiner São Bernardo, Maria Jara Montibeller, Adriano Mondini, Roberta Vieira de Morais Bronzoni
Background In recent years, the state of Mato Grosso has presented one of the highest dengue incidence rates in Brazil. The meeting of the Amazon, Cerrado and Pantanal biomes results in a large variation of rainfall and temperature across different regions of the state. In addition, Mato Grosso has been undergoing intense urban growth since the 1970s, mainly due to the colonization of the Mid-North
-
Human infections by the rat tapeworm Hymenolepis diminuta in China. Trans. Roy. Soc. Trop. Med. Hyg. (IF 2.2) Pub Date : 2023-08-31 Chaoqun Yao
The rat tapeworm Hymenolepis diminuta is a parasite that usually uses rats as a definitive host. It also infects humans and non-human primates. Human infections have been reported in 80 countries worldwide, including China. Nevertheless, nearly all the literature on human infections in China by the rat tapeworm is in Chinese journals, which are very difficult to access by readers outside China. The
-
Seroepidemiology of Toxoplasma gondii infection in blood donors in a population from the northwestern region of São Paulo state, Brazil. Trans. Roy. Soc. Trop. Med. Hyg. (IF 2.2) Pub Date : 2023-08-30 Letícia Carolina Paraboli Assoni,Fabiana Nakashima,Valquíria Pardo de Sousa,Natália Juliana Paduan,Isabela Rufino Andreasse,Thelma Helena Anghinoni,Geraldo Magela de Faria Junior,Octávio Ricci Junior,Lilian Castiglioni,Cinara Cássia Brandão,Luiz Carlos de Mattos,Christiane Maria Ayo
BACKGROUND Toxoplasmosis is one of the most common parasitic infections worldwide with varying prevalence between human populations. These variations are mainly associated with human exposure to risk factors. In this article, the seroprevalence of Toxoplasma gondii infection and the risk factors associated with infection in 1729 blood donors from São José do Rio Preto, São Paulo, Brazil were analysed
-
Reverse Koebner phenomenon in erythema nodosum leprosum. Trans. Roy. Soc. Trop. Med. Hyg. (IF 2.2) Pub Date : 2023-08-26 Sukhdeep Singh,Tarun Narang,Sunil Dogra
BACKGROUND Erythema nodosum leprosum (ENL) is an immunologically mediated phenomenon complicating the course of leprosy. Reverse Koebner phenomenon is the term used to describe the sparing of previously injured or diseased skin by new skin lesions of the disease. METHODS A middle-aged woman with a known case of lepromatous leprosy for the past year presented with an eruption of reddish painful nodules
-
A predictive score for severity in patients with confirmed dengue fever in a tertiary care hospital in Kerala, India Trans. Roy. Soc. Trop. Med. Hyg. (IF 2.2) Pub Date : 2023-08-25 Sruthi Haridas, Gopalakrishna Pillai M, Renjitha Bhaskaran
Background The study aimed to identify predictors of severe dengue during the 2017 epidemic and to develop and validate a simple predictive score for severity. Methods A retrospective analytical study was conducted using clinical and laboratory data from adult dengue patients with a confirmed microbiological diagnosis. The study included patients who presented to a tertiary care centre in Kerala, India
-
Individual, socioeconomic and healthcare access factors influencing the delays in leprosy presentation, diagnosis and treatment: a qualitative study. Trans. Roy. Soc. Trop. Med. Hyg. (IF 2.2) Pub Date : 2023-08-24 Maria Aparecida Alves de Oliveira Serra,Regiane Aquino Alves da Silva,Flavia Ferreira Monari,Julianna Oliveira E Silva,Jurandir Xavier de Sá Junior,Roberta de Araújo E Silva,Iolanda Graepp Fontoura,Marcelino Santos Neto,Márcio Flávio Moura de Araújo
BACKGROUND This study investigated the factors influencing the presentation, diagnosis and treatment of leprosy in primary healthcare. METHODS Qualitative research was conducted on patients undergoing treatment in a priority hyperendemic region for leprosy control in northeastern Brazil. Interviews were conducted between September and December 2020 at primary healthcare centers. Data were analysed
-
Clinical and laboratory factors associated with splenic dysfunction among patients with sickle cell disease in a malaria endemic region Trans. Roy. Soc. Trop. Med. Hyg. (IF 2.2) Pub Date : 2023-08-24 Adama I Ladu, Ngamarju A Satumari, Aisha M Abba, Fatima A Abulfathi, Caroline Jeffery, Adekunle Adekile, Imelda Bates
Background Although loss of splenic function is the expected natural course for individuals with sickle cell disease (SCD), factors such as high HbF and coexistence of alpha thalassemia may ameliorate this process. We evaluated factors associated with two surrogate markers of spleen dysfunction, namely Howell–Jolly bodies (HJBs) and argyrophilic inclusion (AI) red cell counts, among patients with SCD
-
Molecular detection of dengue and chikungunya viruses in surveillance of wild-caught Aedes mosquitoes in Punjab, North India Trans. Roy. Soc. Trop. Med. Hyg. (IF 2.2) Pub Date : 2023-08-18 Taruna Kaura, Subhabrata Sarkar, Vikrant Sharma, Abhishek Mewara, Seema Devi, NazatInder Singh, Kanwalpreet Kaur, Rakesh Sehgal, R K Ratho, Gagandeep Singh Grover
Background Dengue (DENV), Zika (ZIKV) and chikungunya (CHIKV) viruses are transmitted mainly by Aedes mosquitoes and are responsible for a significant global healthcare burden. The current study aimed to detect arboviruses in the Aedes mosquitoes in close proximity of patients during the transmission season. Methods Both immature and adult mosquitoes were collected from in and around the patients’
-
Seroprevalence and risk factors for Toxoplasma gondii infection among pregnant women at Debre Markos Referral Hospital, northwest Ethiopia Trans. Roy. Soc. Trop. Med. Hyg. (IF 2.2) Pub Date : 2023-08-12 Enirsie Kassie, Nigatu Kebede, Tesfu Kassa, Abebe Garoma, Musse Girma, Yewbnesh Asnake, Ayinalem Alemu, Sileshi Degu, Meshesha Tsigie
Background To assess the seroprevalence and risk factors of Toxoplasma gondii infection in pregnant women at the Debre Markos Referral Hospital, northwest Ethiopia. Methods A facility-based cross-sectional study was undertaken among pregnant women from March 2020 to May 2021. Sociodemographic and clinical data were collected from randomly selected participants. Five millilitres of blood was collected
-
Prevalence and associated factors of stunting and thinness among adolescent Sudanese schoolchildren: a cross-sectional study Trans. Roy. Soc. Trop. Med. Hyg. (IF 2.2) Pub Date : 2023-08-11 Jalal A Bilal, Almarwa A Osman, Abdullah Al-Nafeesah, Ashwaq AlEed, Ishag Adam
Background Malnutrition among adolescents is a considerable health problem worldwide. There are scarce data on undernutrition among adolescents in Sudan. Methods A cross‑sectional study was conducted to investigate the prevalence and associated factors of stunting and thinness among adolescent schoolchildren in northern Sudan. The questionnaires were used to collect information on sociodemographics
-
Public perceptions of genomic studies and hereditary diseases in Aari community, South Omo Zone, Ethiopia Trans. Roy. Soc. Trop. Med. Hyg. (IF 2.2) Pub Date : 2023-08-10 Melaku Tilahun, Tewodros Tariku Gebresilase, Abraham Aseffa, Kassa Haile, Teklu Wogayehu, Moi Top Murale, Hailu Yntiso, Nchangwi Syntia Munung, Kidist Bobosha, Mirgissa Kaba
Background Genetic and genomic research is revolutionizing precision medicine; however, addressing ethical and cultural aspects is crucial to ensure ethical conduct and respect for community values and beliefs. This study explored the beliefs, perceptions and concerns of the Aari community in South Ethiopia regarding genetic concepts, hereditary diseases and ethical research practices related to sample
-
Prevalence of trachoma in the non-indigenous Baixo Jaguaribe micro-region, Ceará State, Northeast Brazil Trans. Roy. Soc. Trop. Med. Hyg. (IF 2.2) Pub Date : 2023-08-08 Adjoane Maurício Silva Maciel, Alberto Novaes Ramos Junior, Anderson Fuentes Ferreira, Nádia Maria Girão Saraiva de Almeida, Paulo César de Almeida, Célia Landmann Szwarcwald, Joana da Felicidade Ribeiro Favacho, Luciano Chaves Franco Filho, Vivian da Silva Gomes, Lisandra Serra Damasceno, Manuella Maurício Silva Maciel, Antônio Lucas Delerino, Roberto da Justa Pires Neto
Background The aim of the current study was to estimate the population prevalence of trachoma in non-indigenous populations in the Baixo Jaguaribe micro-region, in the state of Ceará, northeast region of Brazil, 2021–2022. Methods A population-based prevalence survey focusing on detecting cases of trachomatous inflammation-follicular (TF) in children aged 1−9 y and trachomatous trichiasis (TT) ‘unknown
-
Knowledge and perception of asymptomatic malaria in the Volta region of Ghana Trans. Roy. Soc. Trop. Med. Hyg. (IF 2.2) Pub Date : 2023-08-03 Verner N Orish, Caleb Kyeremateng, Baffoe P Appiah, Isaac B Addei, Moses A Ayaba, Precious K Kwadzokpui, Aleksandra Marinkovic, Stephanie Prakash, Chuku Okorie, Ricardo Izurieta, Adekunle Sanyaolu
Background The control of asymptomatic malaria is considered a key aspect of malaria control. This study aimed to assess the knowledge and perception of asymptomatic malaria among people in Ho municipality of the Volta region. Methods A descriptive cross-sectional study involving questionnaire administration was conducted among randomly sampled residents of the Ho municipality of the Volta region of
-
A comparison of changes in venous lactate and haematocrit during fluid resuscitation of dengue haemorrhagic fever Trans. Roy. Soc. Trop. Med. Hyg. (IF 2.2) Pub Date : 2023-08-03 W D Dilshan Priyankara, D G N Samarutilake, Sameera Viswakula, E M Manoj, Ananda Wijewickrama, Nilanka Perera, J K P Wanigasuriya
Background Judicious fluid resuscitation and stringent monitoring of clinical parameters improve the outcome of dengue haemorrhagic fever (DHF). The usefulness of serum lactate to monitor adequate fluid therapy has not been adequately explored. Methods An observational study was conducted in Sri Lanka, recruiting 162 DHF patients within 12 h of diagnosis of the critical phase. Venous lactate level
-
Intestinal parasitic infections and risk analysis among urban refugees in the Klang Valley, Malaysia Trans. Roy. Soc. Trop. Med. Hyg. (IF 2.2) Pub Date : 2023-07-27 Izzah Ruzana Mohd Hanapi, Jerzy M Behnke, Norhidayu Sahimin, Nur Fadlin Saifulazmi, Ashah Sara Jehan Golam Mohammad Khan, Raisya Nur Syazmeen Abdul Mutalib, Yee Ling Lau, Siti Nursheena Mohd Zain
Background Global studies show intestinal parasitic infections (IPIs) have been introduced and spread with refugee inflows from low to high socio-economic countries. However, there is relatively limited information on the prevalence of infections among the community. Methods A 2-year cross-sectional study was conducted to determine the prevalence and associated risk factors for infections among urban
-
Identification and molecular characterization of Culex flavivirus in Culex quinquefasciatus (Diptera: Culicidae): first report from India Trans. Roy. Soc. Trop. Med. Hyg. (IF 2.2) Pub Date : 2023-07-27 A Anakha, Harish Kumar Shah, P A Fathima, R S Aiswarya, P M Ajithlal, N Pradeep Kumar, Ashwani Kumar, Prasanta Saini
Background Culex quinquefasciatus is a notorious vector known to transmit pathogens such as Wuchereria bancrofti (causing Lymphatic filariasis) and flaviviruses such as West Nile virus in India and St. Louis Encephalitis virus in the USA. It is the vector of the Rift Valley Fever virus, also on the African continent. Mosquitoes also harbor other non-pathogenic insect-specific flaviviruses (ISFs), such
-
Non-typhoidal salmonella contamination along the pork value chain in a rural East African setting: a cross-sectional study Trans. Roy. Soc. Trop. Med. Hyg. (IF 2.2) Pub Date : 2023-07-25 Cianjo M Gichuyia, Lian F Thomas, Christine Makena, Linnet Ochieng, Peter B Gathura, Joshua O Onono, Eric M Fèvre
Background Non-typhoidal Salmonella (NTS) is a serious foodborne pathogen that has previously been isolated from pigs presented for slaughter in a rural pork value chain in western Kenya. Methods To understand varying NTS contamination along the value chain we assessed prevalence at slaughter, transport and retail. Suspect isolates from culture were confirmed using matrix-assisted laser desorption-ionization
-
A disfiguring neglected tropical disease sweeps war-torn Yemen: a community-based study of prevalence and risk factors of cutaneous leishmaniasis among rural communities in the western highlands Trans. Roy. Soc. Trop. Med. Hyg. (IF 2.2) Pub Date : 2023-07-24 Manal A Al-Ashwal, Wahib M Atroosh, Abdulelah H Al-Adhroey, Assia A Al-Subbary, Lau Yee-Ling, Hesham M Al-Mekhlafi
Background Cutaneous leishmaniasis (CL) is a major health problem in Yemen and is endemic in many rural areas across the country. Methods A community-based cross-sectional survey followed by unmatched case–control comparisons was conducted among 612 participants in Utmah district, western Yemen. A total of 223 participants were included in the case–control analysis to identify the significant risk
-
Analysis of the availability, effectiveness and equity of deployment of resources in the health system response to COVID-19 in Nigeria. Trans. Roy. Soc. Trop. Med. Hyg. (IF 2.2) Pub Date : 2023-07-22 Nwadiuto C Ojielo,Nkolika P Uguru,Chinyere C Okeke,Obinna E Onwujekwe
BACKGROUND Coronavirus disease 2019 (COVID-19) exposed weaknesses in the health systems of countries such as Nigeria, which affected the effectiveness of the health system response to the pandemic. This paper provides new knowledge on the level of the availability, effectiveness and equity of resources in response to COVID-19 in Nigeria. This is valuable information for improving the delivery of countermeasures
-
miRNA 511_5p is a potential biomarker for ocular toxoplasmosis Trans. Roy. Soc. Trop. Med. Hyg. (IF 2.2) Pub Date : 2023-07-21 Geraldo Magela de Faria Júnior, Laurie Sayuri Kumano, Isabela Bronchtein Gomes, Gláucio Silva Camargos, Cristina da Silva Meira-Strejevitch, Lilian Castiglioni, Mariana Previato, Vera Lucia Pereira-Chioccola, Cinara Cássia Brandão, Luiz Carlos de Mattos
Background Ocular toxoplasmosis (OT) is a frequent clinical manifestation due to infection by Toxoplasma gondii. It is characterized by an inflammatory process involving macrophages activated by pro-inflammatory cytokines. The expression of microRNAs takes place during the inflammatory process and, among them, miRNA 511 regulates the activation of macrophages. This study evaluated the expression of
-
A proposed method of grading malaria chemoprevention efficacy Trans. Roy. Soc. Trop. Med. Hyg. (IF 2.2) Pub Date : 2023-07-10 N J White, C Bonnington, F H Nosten
The efficacy and effectiveness of antimalarial drugs are threatened by increasing levels of resistance and therefore require continuous monitoring. Chemoprevention is increasingly deployed as a malaria control measure, but there are no generally accepted methods of assessment. We propose a simple method of grading the parasitological response to chemoprevention (focusing on seasonal malaria chemoprevention)
-
Antiprotozoal activity of auranofin on Trypanosoma cruzi, Leishmania tropica and Toxoplasma gondii: in vitro and ex vivo study Trans. Roy. Soc. Trop. Med. Hyg. (IF 2.2) Pub Date : 2023-06-28 Ahmet Yıldırım, Ahmet Özbilgin, Kor Yereli
Background Three obligate intracellular protozoan parasite species, which are responsible for significant morbidity and mortality and settle in macrophage cells, affect more than one-half of the world's population, namely, Trypanosoma cruzi, Leishmania tropica and Toxoplasma gondii, which are causative agents of Chagas disease, leishmaniasis and toxoplasmosis, respectively. In the current study, it