当前期刊: Annual Review of Medicine Go to current issue    加入关注   
显示样式:        排序: 导出
我的关注
我的收藏
您暂时未登录!
登录
  • Bariatric Surgery as a Long-Term Treatment for Type 2 Diabetes/Metabolic Syndrome.
    Annu. Rev. Med. (IF 10.091) Pub Date : 2020-01-27
    Zubaidah Nor Hanipah,Philip R Schauer

    Metabolic surgery is increasingly becoming recognized as a more effective treatment for patients with type 2 diabetes (T2D) and obesity as compared to lifestyle modification and medical management alone. Both observational studies and clinical trials have shown metabolic surgery to result in sustained weight loss (20-30%), T2D remission rates ranging from 23% to 60%, and improvement in cardiovascular

    更新日期:2020-01-29
  • Current Approaches to Germline Cancer Genetic Testing.
    Annu. Rev. Med. (IF 10.091) Pub Date : 2019-11-22
    Elena M Stoffel,John M Carethers

    The prevalence of genetic predisposition to cancer is greater than initially appreciated, yet most affected individuals remain undiagnosed. Deleterious germline variants in cancer predisposition genes are implicated in 1 in 10 cases of advanced cancer. Next-generation sequencing technologies have made germline and tumor DNA sequencing more accessible and less expensive. Expanded access to clinical

    更新日期:2020-01-29
  • Precision Management of Advanced Non-Small Cell Lung Cancer.
    Annu. Rev. Med. (IF 10.091) Pub Date : 2020-01-27
    Ching-Yao Yang,James Chih-Hsin Yang,Pan-Chyr Yang

    The rapid evolution of treatment for advanced lung cancer is a story of how scientists have struggled to move from nonselective cytotoxic chemotherapy to personalized precision medicine. In this century, extraordinary advances have been made in the management of advanced and metastatic non-small cell lung cancer, especially in the development of small molecules targeting specific tyrosine kinase receptors

    更新日期:2020-01-29
  • Microbiome Anomalies in Allogeneic Hematopoietic Cell Transplantation.
    Annu. Rev. Med. (IF 10.091) Pub Date : 2020-01-27
    Zaker I Schwabkey,Robert R Jenq

    The microbiome is an integrated part of the human body that can modulate a variety of disease processes and affect prognosis, treatment response, complications, and outcomes. The importance of allogeneic hematopoietic cell transplantation in cancer treatment has resulted in extensive investigations on the interaction between the microbiome and this treatment modality. These investigations are beginning

    更新日期:2020-01-29
  • Omics and Cardiometabolic Disease Risk Prediction.
    Annu. Rev. Med. (IF 10.091) Pub Date : 2020-01-27
    Usman A Tahir,Robert E Gerszten

    Risk assessments are integral for the prevention and management of cardiometabolic disease (CMD). However, individuals may develop CMD without traditional risk factors, necessitating the development of novel biomarkers to aid risk prediction. The emergence of omic technologies, including genomics, proteomics, and metabolomics, has allowed for assessment of orthogonal measures of cardiometabolic risk

    更新日期:2020-01-29
  • Ablation Therapy for Refractory Ventricular Arrhythmias.
    Annu. Rev. Med. (IF 10.091) Pub Date : 2019-11-20
    Pasquale Santangeli,Francis E Marchlinski

    Recurrent ventricular arrhythmias (VAs) are a leading cause of cardiovascular morbidity and mortality. In the last three decades, important advancements have occurred in the understanding of the mechanisms of recurrent VAs, their prognostic implications in different clinical contexts, and their treatment options. VAs occur in structurally normal hearts as well as in patients with underlying heart disease

    更新日期:2020-01-29
  • Atherosclerosis: Making a U Turn.
    Annu. Rev. Med. (IF 10.091) Pub Date : 2020-01-27
    Ira J Goldberg,Gaurav Sharma,Edward A Fisher

    The development of potent cholesterol-reducing medications in the last decade of the twentieth century has altered the approach to prevention and treatment of cardiovascular disease (CVD). Initial experience with statins, and more recently with the addition of PCSK9 inhibitors, has proven that human CVD, like that in animal models, can be halted and regressed. Available clinical data show that the

    更新日期:2020-01-29
  • Cardiac Amyloidosis: Overlooked, Underappreciated, and Treatable.
    Annu. Rev. Med. (IF 10.091) Pub Date : 2020-01-27
    Jonah Rubin,Mathew S Maurer

    Cardiac amyloidosis (CA) is an infiltrative and restrictive cardiomyopathy that leads to heart failure, reduced quality of life, and death. The disease has two main subtypes, transthyretin cardiac amyloidosis (ATTR-CA) and immunoglobulin light chain cardiac amyloidosis (AL-CA), characterized by the nature of the infiltrating protein. ATTR-CA is further subdivided into wild-type (ATTRwt-CA) and variant

    更新日期:2020-01-29
  • Contemporary Application of Cardiovascular Magnetic Resonance Imaging.
    Annu. Rev. Med. (IF 10.091) Pub Date : 2020-01-27
    Yuchi Han,Yucheng Chen,Victor A Ferrari

    Cardiovascular magnetic resonance imaging (CMR) is a comprehensive and versatile diagnostic and prognostic imaging modality that plays an increasingly important role in management of patients with cardiovascular disease. In this review, we discuss CMR applications in nonischemic cardiomyopathy, ischemic heart disease, arrhythmias, right ventricular diseases, and valvular heart disease. We emphasize

    更新日期:2020-01-29
  • Transcatheter Mitral Valve Replacement: Rationale and Current Status.
    Annu. Rev. Med. (IF 10.091) Pub Date : 2020-01-27
    Paul N Fiorilli,Howard C Herrmann

    Mitral regurgitation (MR) is the most prevalent form of moderate or severe valve disease in the developed world. MR can result from impairment of any part of the mitral valve apparatus and is classified as primary (disease of the leaflets) or secondary (functional). The presence of at least moderate MR is associated with increased morbidity and mortality. With the goal of avoiding the risks of traditional

    更新日期:2020-01-29
  • Hiding in Plain Sight: Interleukin-11 Emerges as a Master Regulator of Fibrosis, Tissue Integrity, and Stromal Inflammation.
    Annu. Rev. Med. (IF 10.091) Pub Date : 2020-01-27
    Stuart A Cook,Sebastian Schafer

    Interleukin (IL)-11 is upregulated in a wide variety of fibro-inflammatory diseases such as systemic sclerosis, rheumatoid arthritis, pulmonary fibrosis, inflammatory bowel disease, kidney disease, drug-induced liver injury, and nonalcoholic steatohepatitis. IL-11 is a member of the IL-6 cytokine family and has several distinct properties that define its unique and nonredundant roles in disease. The

    更新日期:2020-01-29
  • Low-FODMAP Diet for Irritable Bowel Syndrome: What We Know and What We Have Yet to Learn.
    Annu. Rev. Med. (IF 10.091) Pub Date : 2020-01-27
    Jerry Liu,William D Chey,Emily Haller,Shanti Eswaran

    Irritable bowel syndrome (IBS) is the most prevalent of gastrointestinal (GI) conditions, affecting millions of people worldwide. Given that most IBS patients associate their GI symptoms with eating food, specific dietary manipulation has become an attractive treatment strategy. A diet low in FODMAPs (fermentable oligosaccharides, disaccharides, monosaccharides, and polyols) has generated the greatest

    更新日期:2020-01-29
  • Broadly Neutralizing Antibodies for HIV Prevention.
    Annu. Rev. Med. (IF 10.091) Pub Date : 2020-01-27
    Shelly T Karuna,Lawrence Corey

    In the last decade, over a dozen potent broadly neutralizing antibodies (bnAbs) to several HIV envelope protein epitopes have been identified, and their in vitro neutralization profiles have been defined. Many have demonstrated prevention efficacy in preclinical trials and favorable safety and pharmacokinetic profiles in early human clinical trials. The first human prevention efficacy trials using

    更新日期:2020-01-29
  • New Therapies for Emerging Endotypes of Asthma.
    Annu. Rev. Med. (IF 10.091) Pub Date : 2019-11-05
    Geoffrey Lowell Chupp,Ravdeep Kaur,Anne Mainardi

    The presentation, pathobiology, and prognosis of asthma are highly heterogeneous and challenging for clinicians to diagnose and treat. In addition to the adaptive immune response that underlies allergic inflammation, innate immune mechanisms are increasingly recognized to be critical mediators of the eosinophilic airway inflammation present in most patients with asthma. Efforts to classify patients

    更新日期:2019-11-05
  • Reversing advanced heart failure by targeting Ca2+ cycling.
    Annu. Rev. Med. (IF 10.091) Pub Date : 2008-01-12
    David M Kaye,Masahiko Hoshijima,Kenneth R Chien

    Heart failure is a major cardiovascular disease, characterized by considerable morbidity and mortality. Despite major advances in the pharmacotherapy of heart failure, the options for patients with severe end-stage symptoms remain limited. However, recent developments in the identification of the molecular basis for the progressive nature of heart failure have identified a number of potentially important

    更新日期:2019-11-01
  • The challenge of hepatitis C in the HIV-infected person.
    Annu. Rev. Med. (IF 10.091) Pub Date : 2008-01-12
    David L Thomas

    Hepatitis C virus (HCV) coinfection occurs in an estimated one quarter of HIV-infected persons in Europe, Australia, and the United States. As use of highly active antiretroviral drugs has markedly reduced opportunistic infections, HCV-related liver disease has emerged as a leading cause of death. HIV infection adversely affects both the natural history and the treatment of hepatitis C. Because there

    更新日期:2019-11-01
  • Herpes simplex: insights on pathogenesis and possible vaccines.
    Annu. Rev. Med. (IF 10.091) Pub Date : 2008-01-12
    David M Koelle,Lawrence Corey

    Abstract Herpes simplex viruses are evolutionarily ancient and ubiquitous. In the past 20 years, there has been increasing recognition of a worldwide pandemic of HSV-2 infection. Moreover, HSV-2 prevalence has increased despite fairly widespread use of antiviral drugs for HSV. The success of HSV-1 and HSV-2 stems from latency within long-lived neurons and frequent mucocutaneous shedding. The generally

    更新日期:2019-11-01
  • A decade of rituximab: improving survival outcomes in non-Hodgkin's lymphoma.
    Annu. Rev. Med. (IF 10.091) Pub Date : 2008-01-12
    Arturo Molina

    The anti-CD20 monoclonal antibody rituximab, first approved for clinical use in 1997, has changed the standard of care for many patients with non-Hodgkin's lymphoma (NHL). Recent data from large randomized clinical trials confirm that the addition of rituximab to standard chemotherapy regimens (chemoimmunotherapy) improves both response rates and survival outcomes in patients with follicular NHL and

    更新日期:2019-11-01
  • Appropriate use of cervical cancer vaccine.
    Annu. Rev. Med. (IF 10.091) Pub Date : 2008-01-12
    Gregory D Zimet,Marcia L Shew,Jessica A Kahn

    Human papillomavirus (HPV) is a necessary, though not sufficient, cause of cervical cancer. Two vaccines have been developed that prevent two HPV types associated with 70% of cervical cancers. One of the vaccines (a quadrivalent vaccine) also prevents two HPV types associated with 90% of genital warts. Both HPV vaccines have shown very good efficacy and safety. This review summarizes the guidelines

    更新日期:2019-11-01
  • Is human hibernation possible?
    Annu. Rev. Med. (IF 10.091) Pub Date : 2008-01-12
    Cheng Chi Lee

    The induction of hypometabolism in cells and organs to reduce ischemia damage holds enormous clinical promise in diverse fields, including treatment of stroke and heart attack. However, the thought that humans can undergo a severe hypometabolic state analogous to hibernation borders on science fiction. Some mammals can enter a severe hypothermic state during hibernation in which metabolic activity

    更新日期:2019-11-01
  • Expanded newborn screening: implications for genomic medicine.
    Annu. Rev. Med. (IF 10.091) Pub Date : 2008-01-12
    Linda L McCabe,Edward R B McCabe

    Newborn screening (NBS) represents the largest volume of genetic testing. The 45-year history of NBS has demonstrated its benefits, as well as the importance of an evidence base. The recent addition of tandem mass spectrometry (MS/MS) resulted in a fivefold increase in the number of tests. Experience with MS/MS also showed that laboratory tests are just one part of the NBS system. The lessons learned

    更新日期:2019-11-01
  • The FDA critical path initiative and its influence on new drug development.
    Annu. Rev. Med. (IF 10.091) Pub Date : 2008-01-12
    Janet Woodcock,Raymond Woosley

    Societal expectations about drug safety and efficacy are rising while productivity in the pharmaceutical industry is falling. In 2004, the US Food and Drug Administration introduced the Critical Path Initiative with the intent of modernizing drug development by incorporating recent scientific advances, such as genomics and advanced imaging technologies, into the process. An important part of the initiative

    更新日期:2019-11-01
  • Advances in antifungal therapy.
    Annu. Rev. Med. (IF 10.091) Pub Date : 2007-10-31
    Carole A Sable,Kim M Strohmaier,Jeffrey A Chodakewitz

    The prevalence of invasive fungal infections (IFIs) has increased over the past three decades owing to the increasing numbers of immunocompromised hosts. These infections are associated with significant morbidity and mortality. Recent significant advances in antifungal therapy include the broad-spectrum triazoles (voriconazole and posaconazole) and a new class of antifungals, the echinocandins (caspofungin

    更新日期:2019-11-01
  • Array-based DNA diagnostics: let the revolution begin.
    Annu. Rev. Med. (IF 10.091) Pub Date : 2007-10-27
    Arthur L Beaudet,John W Belmont

    Advances in the fabrication of DNA microarrays as well as transformations in detection chemistries have vastly increased the throughput for genotyping, DNA sequencing, and array-based copy number analysis (ABCNA). Rapid changes in technology are not only affecting research but also revolutionizing DNA diagnostics. Here we focus on the application of high-throughput ABCNA and genotyping. Targeted and

    更新日期:2019-11-01
  • Medical management of influenza infection.
    Annu. Rev. Med. (IF 10.091) Pub Date : 2007-10-18
    Anne Moscona

    Antiviral drugs are important in the management of seasonal influenza and critical to pandemic planning. Although several other classes of anti-influenza compounds exist, the neuraminidase (NA) inhibitors are currently the only option in most clinical settings. These drugs, zanamivir and oseltamivir, prevent the release of newly replicated influenza virions from infected cells. They are highly effective

    更新日期:2019-11-01
  • Nanotechnology and cancer.
    Annu. Rev. Med. (IF 10.091) Pub Date : 2007-10-17
    James R Heath,Mark E Davis

    The biological picture of cancer is rapidly advancing from models built from phenomenological descriptions to network models derived from systems biology, which can capture the evolving pathophysiology of the disease at the molecular level. The translation of this (still academic) picture into a clinically relevant framework can be enabling for the war on cancer, but it is a scientific and technological

    更新日期:2019-11-01
  • Genetic susceptibility to type 2 diabetes and implications for antidiabetic therapy.
    Annu. Rev. Med. (IF 10.091) Pub Date : 2007-10-17
    Allan F Moore,Jose C Florez

    Despite major advances in our knowledge of glycemic pathophysiology and the availability of multiple therapeutic options to confront type 2 diabetes, unraveling the complex link between genetic risk and environmental factors in this burgeoning epidemic has proven difficult. Linkage approaches have clarified the etiology of monogenic diabetic syndromes and congenital lipodystrophies, and candidate gene

    更新日期:2019-11-01
  • Management of lipids in the prevention of cardiovascular events.
    Annu. Rev. Med. (IF 10.091) Pub Date : 2007-10-17
    Helene Glassberg,Daniel J Rader

    Lipid-modifying therapy has been proven to significantly reduce cardiovascular events and total mortality. Most of the data have come from statin trials. Statin therapy is generally well-tolerated and safe, and for patients who are at higher than average risk of cardiovascular disease, the benefit of lipid-modifying therapy far exceeds the risk. Careful risk assessment is a critical component of effective

    更新日期:2019-11-01
  • Cancer epigenetics: modifications, screening, and therapy.
    Annu. Rev. Med. (IF 10.091) Pub Date : 2007-10-17
    Einav Nili Gal-Yam,Yoshimasa Saito,Gerda Egger,Peter A Jones

    Deregulation of gene expression is a hallmark of cancer. Although genetic lesions have been the focus of cancer research for many years, it has become increasingly recognized that aberrant epigenetic modifications also play major roles in the tumorigenic process. These modifications are imposed on chromatin, do not change the nucleotide sequence of DNA, and are manifested by specific patterns of gene

    更新日期:2019-11-01
  • T cells and NKT cells in the pathogenesis of asthma.
    Annu. Rev. Med. (IF 10.091) Pub Date : 2007-10-17
    Everett H Meyer,Rosemarie H DeKruyff,Dale T Umetsu

    Asthma is an immunological disease with multiple inflammatory and clinical phenotypes, characterized by symptoms of wheezing, shortness of breath, and coughing due to airway hyperreactivity (AHR) and reversible airway obstruction. In allergic asthma, the most common form of asthma, airway inflammation is mediated by adaptive immune recognition of protein allergens by Th2 cells, resulting in airway

    更新日期:2019-11-01
  • Preeclampsia and angiogenic imbalance.
    Annu. Rev. Med. (IF 10.091) Pub Date : 2007-10-17
    Sharon Maynard,Franklin H Epstein,S Ananth Karumanchi

    Preeclampsia is a systemic syndrome of pregnancy that originates in the placenta and is characterized by widespread maternal endothelial dysfunction. Until recently, the molecular pathogenesis of preeclampsia was largely unknown, but recent work suggests a key role for altered expression of placental antiangiogenic factors. Soluble Flt1 and soluble endoglin, secreted by the placenta, are increased

    更新日期:2019-11-01
  • Bacterial and fungal biofilm infections.
    Annu. Rev. Med. (IF 10.091) Pub Date : 2007-10-17
    A Simon Lynch,Gregory T Robertson

    Biofilms are communal structures of microorganisms encased in an exopolymeric coat that form on both natural and abiotic surfaces and have been associated with a variety of persistent infections that respond poorly to conventional antibiotic chemotherapy. Biofilm infections of certain indwelling medical devices by common pathogens such as staphylococci are not only associated with increased morbidity

    更新日期:2019-11-01
  • A role for JAK2 mutations in myeloproliferative diseases.
    Annu. Rev. Med. (IF 10.091) Pub Date : 2007-10-09
    Kelly J Morgan,D Gary Gilliland

    Myeloproliferative disorders (MPDs) are characterized by a clonal expansion of myeloid cells. Over the past two years, the identification of the JAK2V617F mutation in most cases of polycythemia vera (PV) as well as approximately 50% of patients with essential thrombocythemia (ET) and idiopathic myelofibrosis (IMF) has greatly advanced our understanding of MPDs. The JAK2V617F mutation alters the JAK2

    更新日期:2019-11-01
  • Mesenchymal stem cells in acute kidney injury.
    Annu. Rev. Med. (IF 10.091) Pub Date : 2007-10-05
    Benjamin D Humphreys,Joseph V Bonventre

    The potential role of mesenchymal stem cells (MSCs, also called mesenchymal stromal cells) in endogenous repair and cell-based therapies for acute kidney injury (AKI) is under intensive investigation. Preclinical studies indicate that administered MSCs both ameliorate renal injury and accelerate repair. These versatile cells home to sites of injury, where they modulate the repair process. The mechanisms

    更新日期:2019-11-01
  • Genetic determinants of aggressive breast cancer.
    Annu. Rev. Med. (IF 10.091) Pub Date : 2007-10-05
    Alejandra C Ventura,Sofia D Merajver

    The development and spread of breast and other human cancers are caused by the overexpression, mutation, and/or deletion of specific genes that drive these events. Finding genetic and molecular differences between cancerous and healthy cells can reveal the genetic determinants of cancer. This knowledge results in a better understanding of the carcinogenic process and improved predictive power, with

    更新日期:2019-11-01
  • Adaptive treatment strategies in chronic disease.
    Annu. Rev. Med. (IF 10.091) Pub Date : 2007-10-05
    Philip W Lavori,Ree Dawson

    An adaptive treatment strategy (ATS) is a rule for adapting a treatment plan to a patient's history of previous treatments and the response to those treatments. The ongoing management of chronic disease defines an ATS, which may be implicit and hidden or explicit and well-specified. The ATS is characterized by the use of intermediate, early markers of response to dynamically alter treatment decisions

    更新日期:2019-11-01
  • Inherited mitochondrial diseases of DNA replication.
    Annu. Rev. Med. (IF 10.091) Pub Date : 2007-09-26
    William C Copeland

    Mitochondrial genetic diseases can result from defects in mitochondrial DNA (mtDNA) in the form of deletions, point mutations, or depletion, which ultimately cause loss of oxidative phosphorylation. These mutations may be spontaneous, maternally inherited, or a result of inherited nuclear defects in genes that maintain mtDNA. This review focuses on our current understanding of nuclear gene mutations

    更新日期:2019-11-01
  • Antiretroviral drug-based microbicides to prevent HIV-1 sexual transmission.
    Annu. Rev. Med. (IF 10.091) Pub Date : 2007-09-26
    Per Johan Klasse,Robin Shattock,John P Moore

    The development of a vaginal (and perhaps a rectal) microbicide would be of major benefit for slowing the global spread of human immunodeficiency virus type 1 (HIV-1). A microbicide is a gel or related device that, when inserted vaginally or rectally, acts to prevent infection of a woman or a man by HIV-1 during sexual intercourse. A practical microbicide must be not only effective, safe, and user-friendly

    更新日期:2019-11-01
  • Advancements in the treatment of epilepsy.
    Annu. Rev. Med. (IF 10.091) Pub Date : 2007-09-22
    B A Leeman,A J Cole

    Diagnostic tools and treatment options for epilepsy have expanded in recent years. Imaging techniques once confined to research laboratories are now routinely used for clinical purposes. Medications that were unavailable a few years ago are now first-line agents. Patients with refractory seizures push for earlier surgical intervention, consider treatment with medical devices, and actively seek nonpharmacologic

    更新日期:2019-11-01
  • The effect of toll-like receptors and toll-like receptor genetics in human disease.
    Annu. Rev. Med. (IF 10.091) Pub Date : 2007-09-12
    Stavros Garantziotis,John W Hollingsworth,Aimee K Zaas,David A Schwartz

    Toll-like receptors (TLRs) enable innate immune recognition of endogenous and exogenous prototypic ligands. They also orchestrate innate and adaptive immune response to infection, inflammation, and tissue injury. Given their significance in the immune response, it is not surprising that genetic variations of TLRs can affect their function and by extension affect the response of the organism to environmental

    更新日期:2019-11-01
  • Hide-and-seek: the challenge of viral persistence in HIV-1 infection.
    Annu. Rev. Med. (IF 10.091) Pub Date : 2007-09-12
    Luc Geeraert,Günter Kraus,Roger J Pomerantz

    The success of highly active antiretroviral therapy (HAART) for HIV-1 infection has sparked interest in mechanisms by which the virus can persist despite effectively suppressive therapy. Latent HIV-1 reservoirs established early during infection not only prevent sterilizing immunity but also represent a major obstacle to virus eradication. When HIV-1 gains a foothold in the immunologic memory or in

    更新日期:2019-11-01
  • Therapy of Marfan syndrome.
    Annu. Rev. Med. (IF 10.091) Pub Date : 2007-09-12
    Daniel P Judge,Harry C Dietz

    Marfan syndrome is a common inherited disorder of connective tissue caused by deficiency of the matrix protein fibrillin-1. Effective surgical therapy for the most life-threatening manifestation, aortic root aneurysm, has led to a nearly normal lifespan for affected individuals who are appropriately recognized and treated. Traditional medical therapies, such as beta-adrenergic receptor blockade, are

    更新日期:2019-11-01
  • Tissue factor and factor VIIa as therapeutic targets in disorders of hemostasis.
    Annu. Rev. Med. (IF 10.091) Pub Date : 2007-09-12
    Ulla Hedner,Mirella Ezban

    For hemophilia patients with inhibitors against FVIII or FIX, the development of recombinant factor VIIa (rFVIIa) raises the possibility of a therapeutic alternative whose availability and convenience of treatment are comparable to those of FVIII or FIX. In support of this new concept for the treatment of bleeding episodes, pharmacological doses of FVIIa have been shown to induce hemostasis. Pharmacological

    更新日期:2019-11-01
  • Childhood obesity: adrift in the "limbic triangle".
    Annu. Rev. Med. (IF 10.091) Pub Date : 2007-09-12
    Michele L Mietus-Snyder,Robert H Lustig

    The prevalence and severity of childhood obesity have increased steadily over the past three decades. The human species evolved to rigorously defend its lower limit for weight and adiposity but is tolerant of the upper limit, which, until recent times, was rarely approached. Neuroendocrine mechanisms within the limbic core of the brain prevent starvation (ventromedial hypothalamus), heighten reward

    更新日期:2019-11-01
  • Asthma genetics: from linear to multifactorial approaches.
    Annu. Rev. Med. (IF 10.091) Pub Date : 2007-09-12
    Stefano Guerra,Fernando D Martinez

    Asthma risk has a clear hereditary component but, unexpectedly, the majority of reported associations between genetic variants and asthma have not been consistently replicated across studies. Methodological flaws have been indicated as a possible explanation for these inconsistencies. However, an alternative explanation is that the effects of genetic variants depend on other factors whose frequency

    更新日期:2019-11-01
  • EGFR tyrosine kinase inhibitors in lung cancer: an evolving story.
    Annu. Rev. Med. (IF 10.091) Pub Date : 2007-08-25
    Lecia V Sequist,Thomas J Lynch

    Drugs that target the epidermal growth factor receptor (EGFR) have had a major impact on the treatment of non-small cell lung cancer (NSCLC). The use of these drugs has also motivated pivotal advances in the understanding of the molecular biology of NSCLC, including the discovery that mutations in EGFR are associated with dramatic and sustained responses to anti-EGFR treatments. This review summarizes

    更新日期:2019-11-01
  • Advance directives.
    Annu. Rev. Med. (IF 10.091) Pub Date : 2007-08-25
    Linda L Emanuel

    Most patients want some control over their medical care, including-or even especially-when they are too sick to participate in decisions. Clinicians who have to make decisions for patients who are unable to participate often would appreciate guidance from patients' wishes. Advance care planning responds to these needs. The process provides for discussions about goals in different scenarios and allows

    更新日期:2019-11-01
  • Complement regulatory genes and hemolytic uremic syndromes.
    Annu. Rev. Med. (IF 10.091) Pub Date : 2007-08-21
    David Kavanagh,Anna Richards,John Atkinson

    Hemolytic uremic syndrome is a triad of microangiopathic hemolytic anemia, thrombocytopenia, and acute renal failure. It is one of a group of conditions termed the thrombotic microangiopathies, which are characterized by prominent endothelial cell injury. It may be diarrheal-associated or atypical (aHUS). Evidence for a pathogenic role of the alternative pathway of complement was first suggested in

    更新日期:2019-11-01
  • Current concepts in AIDS pathogenesis: insights from the SIV/macaque model.
    Annu. Rev. Med. (IF 10.091) Pub Date : 2007-01-16
    Andrew A Lackner,Ronald S Veazey

    The pathogenesis of AIDS has proven to be quite complex and dynamic, with most of the critical events (e.g., transmission, CD4(+) T cell destruction) occurring in tissues that are not easily accessible for analysis. In addition, although the disease can progress over years, many critical events happen within the first few weeks of infection, when most patients are unaware that they are infected. The

    更新日期:2019-11-01
  • Cytokine therapy for Crohn's disease: advances in translational research.
    Annu. Rev. Med. (IF 10.091) Pub Date : 2007-01-16
    Theresa T Pizarro,Fabio Cominelli

    Crohn's disease (CD) and ulcerative colitis (UC), the two idiopathic inflammatory bowel diseases (IBDs), affect almost two million individuals in North America and several million worldwide. Cytokines are important in the pathogenesis of CD, and their manipulation has successfully reduced disease severity and maintained remission. Following the discovery of novel cytokines and the role they may play

    更新日期:2019-11-01
  • New therapeutic approaches for multiple sclerosis.
    Annu. Rev. Med. (IF 10.091) Pub Date : 2007-01-16
    Philip L De Jager,David A Hafler

    Although several therapies exist for multiple sclerosis (MS), the most common inflammatory demyelinating disease of the central nervous system (CNS), there remains a large unmet clinical need for more effective immunomodulatory treatments in this category of diseases and for interventions that address their neurodegenerative component, which is currently untreated. Progress in our understanding of

    更新日期:2019-11-01
  • End-stage renal disease measures of quality.
    Annu. Rev. Med. (IF 10.091) Pub Date : 2007-01-16
    Jonathan Himmelfarb,Alan S Kliger

    During the past 35 years, there has been a geometric expansion of the population of patients receiving chronic dialysis therapy in the United States. As the size and associated costs of the dialysis population have grown, there has been a consistent and evolving emphasis on measuring and improving the quality of dialysis care. These efforts, aided by robust data collection vehicles, have translated

    更新日期:2019-11-01
  • Airway surface dehydration in cystic fibrosis: pathogenesis and therapy.
    Annu. Rev. Med. (IF 10.091) Pub Date : 2007-01-16
    Richard C Boucher

    Cystic fibrosis (CF) lung disease reflects the failure of airways defense against chronic bacterial infection. Studies of CF cultures, transgenic mice, and CF patients suggest that the initiating event in CF airways disease pathogenesis is reduced airway surface liquid (ASL) volume, i.e., dehydration. CF ASL volume regulation depends on a single extracellular signaling system, ATP, which renders CF

    更新日期:2019-11-01
  • Cardiovascular risks of antiretroviral therapies.
    Annu. Rev. Med. (IF 10.091) Pub Date : 2007-01-16
    Kristin Mondy,Pablo Tebas

    The use of highly active antiretroviral therapy (HAART) has resulted in sustained reductions in mortality from HIV infection. In recent years, HAART has also been associated with metabolic complications that may increase patients' cardiovascular disease risk. Recent studies have begun to support a more complex interaction between HAART, HIV infection itself, and other traditional social and immunologic

    更新日期:2019-11-01
  • Use of stents to treat intracranial cerebrovascular disease.
    Annu. Rev. Med. (IF 10.091) Pub Date : 2007-01-16
    Philip M Meyers,H Christian Schumacher,Kurenai Tanji,Randall T Higashida,Louis R Caplan

    Intracranial atherosclerosis is a common cause of stroke. Although it has been recognized for decades, the lack of successful treatment strategies has limited clinical interest until recently. We review the natural history and pathophysiology of intracranial atherosclerosis. Vascular biomechanics are important to define differences between cerebral arteries and extracranial vessels and partly explain

    更新日期:2019-11-01
  • Acute ischemic stroke: overview of recent therapeutic developments.
    Annu. Rev. Med. (IF 10.091) Pub Date : 2007-01-16
    Nijasri Suwanwela,Walter J Koroshetz

    Stroke, a disorder encompassing all cerebrovascular accidents, is a public health problem of immense proportions across the globe. Therapeutic efforts are directed at three aspects: prevention, acute treatment, and rehabilitation. Preventative measures, which in many instances mirror those for cardiovascular disease, can achieve the greatest public health impact. Measures that enhance the recovery

    更新日期:2019-11-01
  • New approaches in the therapy of cardiomyopathy in muscular dystrophy.
    Annu. Rev. Med. (IF 10.091) Pub Date : 2007-01-16
    Elizabeth M McNally

    Cardiomyopathy is a frequent occurrence in muscular dystrophy, and heart disease in muscular dystrophy can contribute to both morbidity and mortality. A number of novel therapies are being developed for muscular dystrophy, and the efficacy of these therapies for heart disease is unknown. The most common X-linked recessive disease is Duchenne muscular dystrophy (DMD), which arises from defects in the

    更新日期:2019-11-01
  • The leading edge of stem cell therapeutics.
    Annu. Rev. Med. (IF 10.091) Pub Date : 2006-11-15
    Ilyas Singec,Rahul Jandial,Andrew Crain,Guido Nikkhah,Evan Y Snyder

    Stem cells, by virtue of their defining property of self-renewal, represent an unlimited source of potentially functional human cells for basic research and regenerative medicine. Having validated the feasibility of cell-based therapeutic strategies over the past decade, mostly through the use of rodent cells, the stem cell field has now embarked upon a detailed characterization of human cells. Recent

    更新日期:2019-11-01
  • NSAIDs and cancer prevention: targets downstream of COX-2.
    Annu. Rev. Med. (IF 10.091) Pub Date : 2006-11-15
    Yong I Cha,Raymond N DuBois

    Preclinical and clinical studies have clearly shown a benefit of nonsteroidal anti-inflammatory drug (NSAID) use in reducing cancer risk. However, the adverse gastrointestinal and cardiovascular side effects associated with NSAIDs and COX-2 selective inhibitors (coxibs) have provoked more scrutiny of the precise role of specific downstream mediators in the prostaglandin (PG) signaling cascade. NSAIDs

    更新日期:2019-11-01
  • Kidney disease and cardiovascular risk.
    Annu. Rev. Med. (IF 10.091) Pub Date : 2006-11-04
    Marcello Tonelli,Marc A Pfeffer

    Kidney failure and chronic kidney disease (CKD) are associated with accelerated cardiovascular disease, apparently because of a high burden of traditional vascular risk factors and possibly nontraditional risk factors such as inflammation, chronic volume overload, and abnormal calcium-phosphate metabolism. Although the burden of cardiovascular disease in CKD patients is well documented, potentially

    更新日期:2019-11-01
Contents have been reproduced by permission of the publishers.
导出
全部期刊列表>>
向世界展示您的会议墙报和演示文稿
全球疫情及响应:BMC Medicine专题征稿
新版X-MOL期刊搜索和高级搜索功能介绍
化学材料学全球高引用
ACS材料视界
x-mol收录
自然科研论文编辑服务
南方科技大学
南方科技大学
西湖大学
中国科学院长春应化所于聪-4-8
复旦大学
课题组网站
X-MOL
深圳大学二维材料实验室张晗
中山大学化学工程与技术学院
试剂库存
天合科研
down
wechat
bug