当前期刊: Science Go to current issue    加入关注    本刊投稿指南
显示样式:        排序: IF: - GO 导出
我的关注
我的收藏
您暂时未登录!
登录
  • Bifurcation of planetary building blocks during Solar System formation
    Science (IF 41.845) Pub Date : 2021-01-22
    Tim Lichtenberg, Joanna Dra̧żkowska, Maria Schönbächler, Gregor J. Golabek, Thomas O. Hands

    Geochemical and astronomical evidence demonstrates that planet formation occurred in two spatially and temporally separated reservoirs. The origin of this dichotomy is unknown. We use numerical models to investigate how the evolution of the solar protoplanetary disk influenced the timing of protoplanet formation and their internal evolution. Migration of the water snow line can generate two distinct

    更新日期:2021-01-22
  • Ultrafast nanoimaging of the order parameter in a structural phase transition
    Science (IF 41.845) Pub Date : 2021-01-22
    Thomas Danz, Till Domröse, Claus Ropers

    Understanding microscopic processes in materials and devices that can be switched by light requires experimental access to dynamics on nanometer length and femtosecond time scales. Here, we introduce ultrafast dark-field electron microscopy to map the order parameter across a structural phase transition. We use ultrashort laser pulses to locally excite a 1T-TaS2 (1T-polytype of tantalum disulfide)

    更新日期:2021-01-22
  • Unraveling CO adsorption on model single-atom catalysts
    Science (IF 41.845) Pub Date : 2021-01-22
    Jan Hulva, Matthias Meier, Roland Bliem, Zdenek Jakub, Florian Kraushofer, Michael Schmid, Ulrike Diebold, Cesare Franchini, Gareth S. Parkinson

    Understanding how the local environment of a “single-atom” catalyst affects stability and reactivity remains a challenge. We present an in-depth study of copper1, silver1, gold1, nickel1, palladium1, platinum1, rhodium1, and iridium1 species on Fe3O4(001), a model support in which all metals occupy the same twofold-coordinated adsorption site upon deposition at room temperature. Surface science techniques

    更新日期:2021-01-22
  • Iridium-catalyzed Z-retentive asymmetric allylic substitution reactions
    Science (IF 41.845) Pub Date : 2021-01-22
    Ru Jiang, Lu Ding, Chao Zheng, Shu-Li You

    Z-Olefins are challenging synthetic targets owing to their relative thermodynamic instability. Transition metal–catalyzed asymmetric allylic substitution reactions are well known for installing stereocenters adjacent to branched or E-linear olefins. However, analogous reactions for the synthesis of optically active Z-olefin products are rare. Here we report iridium-catalyzed asymmetric allylic substitution

    更新日期:2021-01-22
  • Convergent evolution of pain-inducing defensive venom components in spitting cobras
    Science (IF 41.845) Pub Date : 2021-01-22
    T. D. Kazandjian, D. Petras, S. D. Robinson, J. van Thiel, H. W. Greene, K. Arbuckle, A. Barlow, D. A. Carter, R. M. Wouters, G. Whiteley, S. C. Wagstaff, A. S. Arias, L.-O. Albulescu, A. Plettenberg Laing, C. Hall, A. Heap, S. Penrhyn-Lowe, C. V. McCabe, S. Ainsworth, R. R. da Silva, P. C. Dorrestein, M. K. Richardson, J. M. Gutiérrez, J. J. Calvete, R. A. Harrison, I. Vetter, E. A. B. Undheim, W

    Convergent evolution provides insights into the selective drivers underlying evolutionary change. Snake venoms, with a direct genetic basis and clearly defined functional phenotype, provide a model system for exploring the repeated evolution of adaptations. While snakes use venom primarily for predation, and venom composition often reflects diet specificity, three lineages of cobras have independently

    更新日期:2021-01-22
  • Nanoscale localized contacts for high fill factors in polymer-passivated perovskite solar cells
    Science (IF 41.845) Pub Date : 2021-01-22
    Jun Peng, Daniel Walter, Yuhao Ren, Mike Tebyetekerwa, Yiliang Wu, The Duong, Qiaoling Lin, Juntao Li, Teng Lu, Md Arafat Mahmud, Olivier Lee Cheong Lem, Shenyou Zhao, Wenzhu Liu, Yun Liu, Heping Shen, Li Li, Felipe Kremer, Hieu T. Nguyen, Duk-Yong Choi, Klaus J. Weber, Kylie R. Catchpole, Thomas P. White

    Polymer passivation layers can improve the open-circuit voltage of perovskite solar cells when inserted at the perovskite–charge transport layer interfaces. Unfortunately, many such layers are poor conductors, leading to a trade-off between passivation quality (voltage) and series resistance (fill factor, FF). Here, we introduce a nanopatterned electron transport layer that overcomes this trade-off

    更新日期:2021-01-22
  • Transvection regulates the sex-biased expression of a fly X-linked gene
    Science (IF 41.845) Pub Date : 2021-01-22
    Charalampos Chrysovalantis Galouzis, Benjamin Prud’homme

    Sexual dimorphism in animals results from sex-biased gene expression patterns. These patterns are controlled by genetic sex determination hierarchies that establish the sex of an individual. Here we show that the male-biased wing expression pattern of the Drosophila biarmipes gene yellow, located on the X chromosome, is independent of the fly sex determination hierarchy. Instead, we find that a regulatory

    更新日期:2021-01-22
  • Host succinate is an activation signal for Salmonella virulence during intracellular infection
    Science (IF 41.845) Pub Date : 2021-01-22
    Gili Rosenberg, Dror Yehezkel, Dotan Hoffman, Camilla Ciolli Mattioli, Moran Fremder, Hadar Ben-Arosh, Leia Vainman, Noa Nissani, Shelly Hen-Avivi, Shirley Brenner, Maxim Itkin, Sergey Malitsky, Ehud Ohana, Noa Bossel Ben-Moshe, Roi Avraham

    Key to the success of intracellular pathogens is the ability to sense and respond to a changing host cell environment. Macrophages exposed to microbial products undergo metabolic changes that drive inflammatory responses. However, the role of macrophage metabolic reprogramming in bacterial adaptation to the intracellular environment has not been explored. Here, using metabolic profiling and dual RNA

    更新日期:2021-01-22
  • Glycolysis fuels phosphoinositide 3-kinase signaling to bolster T cell immunity
    Science (IF 41.845) Pub Date : 2021-01-22
    Ke Xu, Na Yin, Min Peng, Efstathios G. Stamatiades, Amy Shyu, Peng Li, Xian Zhang, Mytrang H. Do, Zhaoquan Wang, Kristelle J. Capistrano, Chun Chou, Andrew G. Levine, Alexander Y. Rudensky, Ming O. Li

    Infection triggers expansion and effector differentiation of T cells specific for microbial antigens in association with metabolic reprograming. We found that the glycolytic enzyme lactate dehydrogenase A (LDHA) is induced in CD8+ T effector cells through phosphoinositide 3-kinase (PI3K) signaling. In turn, ablation of LDHA inhibits PI3K-dependent phosphorylation of Akt and its transcription factor

    更新日期:2021-01-22
  • Clock genes and environmental cues coordinate Anopheles pheromone synthesis, swarming, and mating
    Science (IF 41.845) Pub Date : 2021-01-22
    Guandong Wang, Joel Vega-Rodríguez, Abdoulaye Diabate, Jingnan Liu, Chunlai Cui, Charles Nignan, Ling Dong, Fang Li, Cheick Oumar Ouedrago, Abdoul Malik Bandaogo, Péguédwindé Simon Sawadogo, Hamidou Maiga, Thiago Luiz Alves e Silva, Tales Vicari Pascini, Sibao Wang, Marcelo Jacobs-Lorena

    Anopheles mating is initiated by the swarming of males at dusk followed by females flying into the swarm. Here, we show that mosquito swarming and mating are coordinately guided by clock genes, light, and temperature. Transcriptome analysis shows up-regulation of the clock genes period (per) and timeless (tim) in the head of field-caught swarming Anopheles coluzzii males. Knockdown of per and tim expression

    更新日期:2021-01-22
  • Ancient balancing selection maintains incompatible versions of the galactose pathway in yeast
    Science (IF 41.845) Pub Date : 2021-01-22
    James Boocock, Meru J. Sadhu, Arun Durvasula, Joshua S. Bloom, Leonid Kruglyak

    Metabolic pathways differ across species but are expected to be similar within a species. We discovered two functional, incompatible versions of the galactose pathway in Saccharomyces cerevisiae. We identified a three-locus genetic interaction for growth in galactose, and used precisely engineered alleles to show that it arises from variation in the galactose utilization genes GAL2, GAL1/10/7, and

    更新日期:2021-01-22
  • JARID2 and AEBP2 regulate PRC2 in the presence of H2AK119ub1 and other histone modifications
    Science (IF 41.845) Pub Date : 2021-01-22
    Vignesh Kasinath, Curtis Beck, Paul Sauer, Simon Poepsel, Jennifer Kosmatka, Marco Faini, Daniel Toso, Ruedi Aebersold, Eva Nogales

    Polycomb repressive complexes 1 and 2 (PRC1 and PRC2) cooperate to determine cell identity by epigenetic gene expression regulation. However, the mechanism of PRC2 recruitment by means of recognition of PRC1-mediated H2AK119ub1 remains poorly understood. Our PRC2 cryo–electron microscopy structure with cofactors JARID2 and AEBP2 bound to a H2AK119ub1-containing nucleosome reveals a bridge helix in

    更新日期:2021-01-22
  • Mapping the molecular and cellular complexity of cortical malformations
    Science (IF 41.845) Pub Date : 2021-01-22
    Esther Klingler, Fiona Francis, Denis Jabaudon, Silvia Cappello

    The cerebral cortex is an intricate structure that controls human features such as language and cognition. Cortical functions rely on specialized neurons that emerge during development from complex molecular and cellular interactions. Neurodevelopmental disorders occur when one or several of these steps is incorrectly executed. Although a number of causal genes and disease phenotypes have been identified

    更新日期:2021-01-22
  • Developmental cell programs are co-opted in inflammatory skin disease
    Science (IF 41.845) Pub Date : 2021-01-22
    Gary Reynolds, Peter Vegh, James Fletcher, Elizabeth F. M. Poyner, Emily Stephenson, Issac Goh, Rachel A. Botting, Ni Huang, Bayanne Olabi, Anna Dubois, David Dixon, Kile Green, Daniel Maunder, Justin Engelbert, Mirjana Efremova, Krzysztof Polański, Laura Jardine, Claire Jones, Thomas Ness, Dave Horsfall, Jim McGrath, Christopher Carey, Dorin-Mirel Popescu, Simone Webb, Xiao-nong Wang, Ben Sayer, Jong-Eun

    The skin confers biophysical and immunological protection through a complex cellular network established early in embryonic development. We profiled the transcriptomes of more than 500,000 single cells from developing human fetal skin, healthy adult skin, and adult skin with atopic dermatitis and psoriasis. We leveraged these datasets to compare cell states across development, homeostasis, and disease

    更新日期:2021-01-22
  • Regulation of the Dot1 histone H3K79 methyltransferase by histone H4K16 acetylation
    Science (IF 41.845) Pub Date : 2021-01-22
    Marco Igor Valencia-Sánchez, Pablo De Ioannes, Miao Wang, David M. Truong, Rachel Lee, Jean-Paul Armache, Jef D. Boeke, Karim-Jean Armache

    Dot1 (disruptor of telomeric silencing-1), the histone H3 lysine 79 (H3K79) methyltransferase, is conserved throughout evolution, and its deregulation is found in human leukemias. Here, we provide evidence that acetylation of histone H4 allosterically stimulates yeast Dot1 in a manner distinct from but coordinating with histone H2B ubiquitination (H2BUb). We further demonstrate that this stimulatory

    更新日期:2021-01-22
  • Noncanonical scaffolding of Gαi and β-arrestin by G protein–coupled receptors
    Science (IF 41.845) Pub Date : 2021-01-21
    Jeffrey S. Smith, Thomas F. Pack, Asuka Inoue, Claudia Lee, Kevin Zheng, Issac Choi, Dylan S. Eiger, Anmol Warman, Xinyu Xiong, Zhiyuan Ma, Gayathri Viswanathan, Ian M. Levitan, Lauren K. Rochelle, Dean P. Staus, Joshua C. Snyder, Alem W. Kahsai, Marc G. Caron, Sudarshan Rajagopal

    Heterotrimeric guanine nucleotide-binding protein (G protein)-coupled receptors (GPCRs) are common drug targets and canonically couple to specific Gα protein subtypes and β-arrestin adaptor proteins. G protein- and β-arrestin-mediated signaling have been considered separable. We show GPCRs promote a direct interaction between Gαi protein subtype family members and β-arrestins, regardless of their canonical

    更新日期:2021-01-22
  • Model-informed COVID-19 vaccine prioritization strategies by age and serostatus
    Science (IF 41.845) Pub Date : 2021-01-21
    Kate M. Bubar, Kyle Reinholt, Stephen M. Kissler, Marc Lipsitch, Sarah Cobey, Yonatan H. Grad, Daniel B. Larremore

    Limited initial supply of SARS-CoV-2 vaccine raises the question of how to prioritize available doses. Here, we used a mathematical model to compare five age-stratified prioritization strategies. A highly effective transmission-blocking vaccine prioritized to adults ages 20-49 years minimized cumulative incidence, but mortality and years of life lost were minimized in most scenarios when the vaccine

    更新日期:2021-01-22
  • Single-cell lineages reveal the rates, routes, and drivers of metastasis in cancer xenografts
    Science (IF 41.845) Pub Date : 2021-01-21
    Jeffrey J. Quinn, Matthew G. Jones, Ross A. Okimoto, Shigeki Nanjo, Michelle M. Chan, Nir Yosef, Trever G. Bivona, Jonathan S. Weissman

    Detailed phylogenies of tumor populations can recount the history and chronology of critical events during cancer progression, such as metastatic dissemination. We applied a Cas9-based, single-cell lineage tracer to study the rates, routes, and drivers of metastasis in a lung cancer xenograft mouse model. We report deeply resolved phylogenies for tens of thousands of cancer cells traced over months

    更新日期:2021-01-22
  • Two-dimensional superconductivity and anisotropic transport at KTaO3 (111) interfaces
    Science (IF 41.845) Pub Date : 2021-01-21
    Changjiang Liu, Xi Yan, Dafei Jin, Yang Ma, Haw-Wen Hsiao, Yulin Lin, Terence M. Bretz-Sullivan, Xianjing Zhou, John Pearson, Brandon Fisher, J. Samuel Jiang, Wei Han, Jian-Min Zuo, Jianguo Wen, Dillon D. Fong, Jirong Sun, Hua Zhou, Anand Bhattacharya

    The unique electronic structure found at interfaces between materials can allow unconventional quantum states to emerge. Here we report on the discovery of superconductivity in electron gases formed at interfaces between (111) oriented KTaO3 and insulating overlayers of either EuO or LaAlO3. The superconducting transition temperature, approaching 2.2 K, is about one order of magnitude higher than that

    更新日期:2021-01-22
  • Controlled hydroxylations of diterpenoids allow for plant chemical defense without autotoxicity
    Science (IF 41.845) Pub Date : 2021-01-15
    Jiancai Li, Rayko Halitschke, Dapeng Li, Christian Paetz, Haichao Su, Sven Heiling, Shuqing Xu, Ian T. Baldwin

    Many plant specialized metabolites function in herbivore defense, and abrogating particular steps in their biosynthetic pathways frequently causes autotoxicity. However, the molecular mechanisms underlying their defense and autotoxicity remain unclear. Here, we show that silencing two cytochrome P450s involved in diterpene biosynthesis in the wild tobacco Nicotiana attenuata causes severe autotoxicity

    更新日期:2021-01-15
  • Formation of α clusters in dilute neutron-rich matter
    Science (IF 41.845) Pub Date : 2021-01-15
    Junki Tanaka, Zaihong Yang, Stefan Typel, Satoshi Adachi, Shiwei Bai, Patrik van Beek, Didier Beaumel, Yuki Fujikawa, Jiaxing Han, Sebastian Heil, Siwei Huang, Azusa Inoue, Ying Jiang, Marco Knösel, Nobuyuki Kobayashi, Yuki Kubota, Wei Liu, Jianling Lou, Yukie Maeda, Yohei Matsuda, Kenjiro Miki, Shoken Nakamura, Kazuyuki Ogata, Valerii Panin, Heiko Scheit, Fabia Schindler, Philipp Schrock, Dmytro Symochko

    The surface of neutron-rich heavy nuclei, with a neutron skin created by excess neutrons, provides an important terrestrial model system to study dilute neutron-rich matter. By using quasi-free α cluster–knockout reactions, we obtained direct experimental evidence for the formation of α clusters at the surface of neutron-rich tin isotopes. The observed monotonous decrease of the reaction cross sections

    更新日期:2021-01-15
  • Senolysis by glutaminolysis inhibition ameliorates various age-associated disorders
    Science (IF 41.845) Pub Date : 2021-01-15
    Yoshikazu Johmura, Takehiro Yamanaka, Satotaka Omori, Teh-Wei Wang, Yuki Sugiura, Masaki Matsumoto, Narumi Suzuki, Soichiro Kumamoto, Kiyoshi Yamaguchi, Seira Hatakeyama, Tomoyo Takami, Rui Yamaguchi, Eigo Shimizu, Kazutaka Ikeda, Nobuyuki Okahashi, Ryuta Mikawa, Makoto Suematsu, Makoto Arita, Masataka Sugimoto, Keiichi I. Nakayama, Yoichi Furukawa, Seiya Imoto, Makoto Nakanishi

    Removal of senescent cells (senolysis) has been proposed to be beneficial for improving age-associated pathologies, but the molecular pathways for such senolytic activity have not yet emerged. Here, we identified glutaminase 1 (GLS1) as an essential gene for the survival of human senescent cells. The intracellular pH in senescent cells was lowered by lysosomal membrane damage, and this lowered pH induced

    更新日期:2021-01-15
  • GPER1 is required to protect fetal health from maternal inflammation
    Science (IF 41.845) Pub Date : 2021-01-15
    Alfred T. Harding, Marisa A. Goff, Heather M. Froggatt, Jean K. Lim, Nicholas S. Heaton

    Type I interferon (IFN) signaling in fetal tissues causes developmental abnormalities and fetal demise. Although pathogens that infect fetal tissues can induce birth defects through the local production of type I IFN, it remains unknown why systemic IFN generated during maternal infections only rarely causes fetal developmental defects. Here, we report that activation of the guanine nucleotide–binding

    更新日期:2021-01-15
  • Plant roots sense soil compaction through restricted ethylene diffusion
    Science (IF 41.845) Pub Date : 2021-01-15
    Bipin K. Pandey, Guoqiang Huang, Rahul Bhosale, Sjon Hartman, Craig J. Sturrock, Lottie Jose, Olivier C. Martin, Michal Karady, Laurentius A. C. J. Voesenek, Karin Ljung, Jonathan P. Lynch, Kathleen M. Brown, William R. Whalley, Sacha J. Mooney, Dabing Zhang, Malcolm J. Bennett

    Soil compaction represents a major challenge for modern agriculture. Compaction is intuitively thought to reduce root growth by limiting the ability of roots to penetrate harder soils. We report that root growth in compacted soil is instead actively suppressed by the volatile hormone ethylene. We found that mutant Arabidopsis and rice roots that were insensitive to ethylene penetrated compacted soil

    更新日期:2021-01-15
  • Driving energetically unfavorable dehydrogenation dynamics with plasmonics
    Science (IF 41.845) Pub Date : 2021-01-15
    Katherine Sytwu, Michal Vadai, Fariah Hayee, Daniel K. Angell, Alan Dai, Jefferson Dixon, Jennifer A. Dionne

    Nanoparticle surface structure and geometry generally dictate where chemical transformations occur, with higher chemical activity at sites with lower activation energies. Here, we show how optical excitation of plasmons enables spatially modified phase transformations, activating otherwise energetically unfavorable sites. We have designed a crossed-bar Au-PdHx antenna-reactor system that localizes

    更新日期:2021-01-15
  • Learning the language of viral evolution and escape
    Science (IF 41.845) Pub Date : 2021-01-15
    Brian Hie, Ellen D. Zhong, Bonnie Berger, Bryan Bryson

    The ability for viruses to mutate and evade the human immune system and cause infection, called viral escape, remains an obstacle to antiviral and vaccine development. Understanding the complex rules that govern escape could inform therapeutic design. We modeled viral escape with machine learning algorithms originally developed for human natural language. We identified escape mutations as those that

    更新日期:2021-01-15
  • Three-quarters attack rate of SARS-CoV-2 in the Brazilian Amazon during a largely unmitigated epidemic
    Science (IF 41.845) Pub Date : 2021-01-15
    Lewis F. Buss, Carlos A. Prete, Claudia M. M. Abrahim, Alfredo Mendrone, Tassila Salomon, Cesar de Almeida-Neto, Rafael F. O. França, Maria C. Belotti, Maria P. S. S. Carvalho, Allyson G. Costa, Myuki A. E. Crispim, Suzete C. Ferreira, Nelson A. Fraiji, Susie Gurzenda, Charles Whittaker, Leonardo T. Kamaura, Pedro L. Takecian, Pedro da Silva Peixoto, Marcio K. Oikawa, Anna S. Nishiya, Vanderson Rocha

    Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spread rapidly in Manaus, the capital of Amazonas state in northern Brazil. The attack rate there is an estimate of the final size of the largely unmitigated epidemic that occurred in Manaus. We use a convenience sample of blood donors to show that by June 2020, 1 month after the epidemic peak in Manaus, 44% of the population had detectable

    更新日期:2021-01-15
  • Local convergence of behavior across species
    Science (IF 41.845) Pub Date : 2021-01-15
    Toman Barsbai, Dieter Lukas, Andreas Pondorfer

    Behavior is a way for organisms to respond flexibly to the environmental conditions they encounter. Our own species exhibits large behavioral flexibility and occurs in all terrestrial habitats, sharing these environments with many other species. It remains unclear to what extent a shared environment constrains behavior and whether these constraints apply similarly across species. Here, we show that

    更新日期:2021-01-15
  • Topological pumping of a 1D dipolar gas into strongly correlated prethermal states
    Science (IF 41.845) Pub Date : 2021-01-15
    Wil Kao, Kuan-Yu Li, Kuan-Yu Lin, Sarang Gopalakrishnan, Benjamin L. Lev

    Long-lived excited states of interacting quantum systems that retain quantum correlations and evade thermalization are of great fundamental interest. We create nonthermal states in a bosonic one-dimensional (1D) quantum gas of dysprosium by stabilizing a super-Tonks-Girardeau gas against collapse and thermalization with repulsive long-range dipolar interactions. Stiffness and energy-per-particle measurements

    更新日期:2021-01-15
  • Cryo-EM structure of the B cell co-receptor CD19 bound to the tetraspanin CD81
    Science (IF 41.845) Pub Date : 2021-01-15
    Katherine J. Susa, Shaun Rawson, Andrew C. Kruse, Stephen C. Blacklow

    Signaling through the CD19-CD81 co-receptor complex, in combination with the B cell receptor, is a critical determinant of B cell development and activation. It is unknown how CD81 engages CD19 to enable co-receptor function. Here, we report a 3.8-angstrom structure of the CD19-CD81 complex bound to a therapeutic antigen-binding fragment, determined by cryo–electron microscopy (cryo-EM). The structure

    更新日期:2021-01-15
  • Structure of a transcribing RNA polymerase II–U1 snRNP complex
    Science (IF 41.845) Pub Date : 2021-01-15
    Suyang Zhang, Shintaro Aibara, Seychelle M. Vos, Dmitry E. Agafonov, Reinhard Lührmann, Patrick Cramer

    To initiate cotranscriptional splicing, RNA polymerase II (Pol II) recruits the U1 small nuclear ribonucleoprotein particle (U1 snRNP) to nascent precursor messenger RNA (pre-mRNA). Here, we report the cryo–electron microscopy structure of a mammalian transcribing Pol II–U1 snRNP complex. The structure reveals that Pol II and U1 snRNP interact directly. This interaction positions the pre-mRNA 5′ splice

    更新日期:2021-01-15
  • Noncanonical transnitrosylation network contributes to synapse loss in Alzheimer’s disease
    Science (IF 41.845) Pub Date : 2021-01-15
    Tomohiro Nakamura, Chang-ki Oh, Lujian Liao, Xu Zhang, Kevin M. Lopez, Daniel Gibbs, Amanda K. Deal, Henry R. Scott, Brian Spencer, Eliezer Masliah, Robert A. Rissman, John R. Yates, Stuart A. Lipton

    Here we describe mechanistically distinct enzymes (a kinase, a guanosine triphosphatase, and a ubiquitin protein hydrolase) that function in disparate biochemical pathways and can also act in concert to mediate a series of redox reactions. Each enzyme manifests a second, noncanonical function—transnitrosylation—that triggers a pathological biochemical cascade in mouse models and in humans with Alzheimer’s

    更新日期:2021-01-15
  • Transmission heterogeneities, kinetics, and controllability of SARS-CoV-2
    Science (IF 41.845) Pub Date : 2021-01-15
    Kaiyuan Sun, Wei Wang, Lidong Gao, Yan Wang, Kaiwei Luo, Lingshuang Ren, Zhifei Zhan, Xinghui Chen, Shanlu Zhao, Yiwei Huang, Qianlai Sun, Ziyan Liu, Maria Litvinova, Alessandro Vespignani, Marco Ajelli, Cécile Viboud, Hongjie Yu

    A long-standing question in infectious disease dynamics concerns the role of transmission heterogeneities, which are driven by demography, behavior, and interventions. On the basis of detailed patient and contact-tracing data in Hunan, China, we find that 80% of secondary infections traced back to 15% of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) primary infections, which indicates

    更新日期:2021-01-15
  • Aberrant type 1 immunity drives susceptibility to mucosal fungal infections
    Science (IF 41.845) Pub Date : 2021-01-15
    Timothy J. Break, Vasileios Oikonomou, Nicolas Dutzan, Jigar V. Desai, Marc Swidergall, Tilo Freiwald, Daniel Chauss, Oliver J. Harrison, Julie Alejo, Drake W. Williams, Stefania Pittaluga, Chyi-Chia R. Lee, Nicolas Bouladoux, Muthulekha Swamydas, Kevin W. Hoffman, Teresa Greenwell-Wild, Vincent M. Bruno, Lindsey B. Rosen, Wint Lwin, Andy Renteria, Sergio M. Pontejo, John P. Shannon, Ian A. Myles,

    Human monogenic disorders have revealed the critical contribution of type 17 responses in mucosal fungal surveillance. We unexpectedly found that in certain settings, enhanced type 1 immunity rather than defective type 17 responses can promote mucosal fungal infection susceptibility. Notably, in mice and humans with AIRE deficiency, an autoimmune disease characterized by selective susceptibility to

    更新日期:2021-01-15
  • Phylodynamics for cell biologists
    Science (IF 41.845) Pub Date : 2021-01-15
    T. Stadler, O. G. Pybus, M. P. H. Stumpf

    Multicellular organisms are composed of cells connected by ancestry and descent from progenitor cells. The dynamics of cell birth, death, and inheritance within an organism give rise to the fundamental processes of development, differentiation, and cancer. Technical advances in molecular biology now allow us to study cellular composition, ancestry, and evolution at the resolution of individual cells

    更新日期:2021-01-15
  • A structure of human Scap bound to Insig-2 suggests how their interaction is regulated by sterols
    Science (IF 41.845) Pub Date : 2021-01-14
    Renhong Yan, Pingping Cao, Wenqi Song, Hongwu Qian, Ximing Du, Hudson W. Coates, Xin Zhao, Yaning Li, Shuai Gao, Xin Gong, Ximing Liu, Jianhua Sui, Jianlin Lei, Hongyuan Yang, Andrew J. Brown, Qiang Zhou, Chuangye Yan, Nieng Yan

    The SREBP pathway controls cellular homeostasis of sterols. The key players in this pathway, Scap and Insig-1/2, are membrane-embedded sterol sensors. 25-hydroxycholesterol (25HC)-dependent association of Scap and Insigs acts as the master switch for the SREBP pathway. Here, we present cryo-EM analysis of the human Scap and Insig-2 complex in the presence of 25HC, with the transmembrane (TM) domains

    更新日期:2021-01-15
  • Widespread haploid-biased gene expression enables sperm-level natural selection
    Science (IF 41.845) Pub Date : 2021-01-14
    Kunal Bhutani, Katherine Stansifer, Simina Ticau, Lazar Bojic, Alexandra-Chloé Villani, Joanna Slisz, Claudia M. Cremers, Christian Roy, Jerry Donovan, Brian Fiske, Robin C. Friedman

    Sperm are haploid, but must be functionally equivalent to distribute alleles equally among progeny. Accordingly, gene products are shared through spermatid cytoplasmic bridges which erase phenotypic differences between individual haploid sperm. Here, we show that a large class of mammalian genes are not completely shared across these bridges. We term these genes “genoinformative markers” (GIMs) and

    更新日期:2021-01-15
  • Mosaic nanoparticles elicit cross-reactive immune responses to zoonotic coronaviruses in mice
    Science (IF 41.845) Pub Date : 2021-01-12
    Alexander A. Cohen, Priyanthi N. P. Gnanapragasam, Yu E. Lee, Pauline R. Hoffman, Susan Ou, Leesa M. Kakutani, Jennifer R. Keeffe, Hung-Jen Wu, Mark Howarth, Anthony P. West, Christopher O. Barnes, Michel C. Nussenzweig, Pamela J. Bjorkman

    Protection against SARS-CoV-2 and SARS-related emergent zoonotic coronaviruses is urgently needed. We made homotypic nanoparticles displaying the receptor-binding domain (RBD) of SARS-CoV-2 or co-displaying SARS-CoV-2 RBD along with RBDs from animal betacoronaviruses that represent threats to humans (mosaic nanoparticles; 4-8 distinct RBDs). Mice immunized with RBD-nanoparticles, but not soluble antigen

    更新日期:2021-01-13
  • Immunological characteristics govern the transition of COVID-19 to endemicity
    Science (IF 41.845) Pub Date : 2021-01-12
    Jennie S. Lavine, Ottar N. Bjornstad, Rustom Antia

    We are currently faced with the question of how the CoV-2 severity may change in the years ahead. Our analysis of immunological and epidemiological data on endemic human coronaviruses (HCoVs) shows that infection-blocking immunity wanes rapidly, but disease-reducing immunity is long-lived. Our model, incorporating these components of immunity, recapitulates both the current severity of CoV-2 and the

    更新日期:2021-01-13
  • Structure-guided multivalent nanobodies block SARS-CoV-2 infection and suppress mutational escape
    Science (IF 41.845) Pub Date : 2021-01-12
    Paul-Albert Koenig, Hrishikesh Das, Hejun Liu, Beate M. Kümmerer, Florian N. Gohr, Lea-Marie Jenster, Lisa D. J. Schiffelers, Yonas M. Tesfamariam, Miki Uchima, Jennifer D. Wuerth, Karl Gatterdam, Natalia Ruetalo, Maria H. Christensen, Caroline I. Fandrey, Sabine Normann, Jan M. P. Tödtmann, Steffen Pritzl, Leo Hanke, Jannik Boos, Meng Yuan, Xueyong Zhu, Jonathan L. Schmid-Burgk, Hiroki Kato, Michael

    The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic continues to spread with devastating consequences. For passive immunization efforts, nanobodies have size and cost advantages over conventional antibodies. Here, we generated four neutralizing nanobodies that target the receptor-binding domain of the SARS-CoV-2 spike protein. We defined two distinct binding epitopes using x-ray

    更新日期:2021-01-13
  • Establishment and lineage dynamics of the SARS-CoV-2 epidemic in the UK
    Science (IF 41.845) Pub Date : 2021-01-08
    Louis du Plessis, John T. McCrone, Alexander E. Zarebski, Verity Hill, Christopher Ruis, Bernardo Gutierrez, Jayna Raghwani, Jordan Ashworth, Rachel Colquhoun, Thomas R. Connor, Nuno R. Faria, Ben Jackson, Nicholas J. Loman, Áine O’Toole, Samuel M. Nicholls, Kris V. Parag, Emily Scher, Tetyana I. Vasylyeva, Erik M. Volz, Alexander Watts, Isaac I. Bogoch, Kamran Khan, COVID-19 Genomics UK (COG-UK) Consortium†

    The UK’s COVID-19 epidemic during early 2020 was one of world’s largest and unusually well represented by virus genomic sampling. Here we reveal the fine-scale genetic lineage structure of this epidemic through analysis of 50,887 SARS-CoV-2 genomes, including 26,181 from the UK sampled throughout the country’s first wave of infection. Using large-scale phylogenetic analyses, combined with epidemiological

    更新日期:2021-01-10
  • RNA stabilization by a poly(A) tail 3ʹ-end binding pocket and other modes of poly(A)-RNA interaction
    Science (IF 41.845) Pub Date : 2021-01-07
    Seyed-Fakhreddin Torabi, Anand T. Vaidya, Kazimierz T. Tycowski, Suzanne J. DeGregorio, Jimin Wang, Mei-Di Shu, Thomas A. Steitz, Joan A. Steitz

    Poly(A) tail addition to the 3ʹ end of a wide range of RNAs is a highly conserved modification that plays a central role in cellular RNA function. Elements for nuclear expression (ENEs) are cis-acting RNA elements that stabilize poly(A) tails by sequestering them in RNA triplex structures. A 2.89-Å resolution crystal structure of a double ENE from a rice hAT transposon mRNA complexed with poly(A)28

    更新日期:2021-01-08
  • Characterization of a common progenitor pool of the epicardium and myocardium
    Science (IF 41.845) Pub Date : 2021-01-07
    Richard C. V. Tyser, Ximena Ibarra-Soria, Katie McDole, Satish A. Jayaram, Jonathan Godwin, Teun A. H. van den Brand, Antonio M. A. Miranda, Antonio Scialdone, Philipp J. Keller, John C. Marioni, Shankar Srinivas

    The mammalian heart is derived from multiple cell lineages; however, our understanding of when and how the diverse cardiac cell types arise is limited. We mapped the origin of the embryonic mouse heart at single-cell resolution using a combination of transcriptomic, imaging, and genetic lineage labeling approaches. This provided a transcriptional and anatomic definition of cardiac progenitor types

    更新日期:2021-01-08
  • A noninflammatory mRNA vaccine for treatment of experimental autoimmune encephalomyelitis
    Science (IF 41.845) Pub Date : 2021-01-08
    Christina Krienke, Laura Kolb, Elif Diken, Michael Streuber, Sarah Kirchhoff, Thomas Bukur, Özlem Akilli-Öztürk, Lena M. Kranz, Hendrik Berger, Jutta Petschenka, Mustafa Diken, Sebastian Kreiter, Nir Yogev, Ari Waisman, Katalin Karikó, Özlem Türeci, Ugur Sahin

    The ability to control autoreactive T cells without inducing systemic immune suppression is the major goal for treatment of autoimmune diseases. The key challenge is the safe and efficient delivery of pharmaceutically well-defined antigens in a noninflammatory context. Here, we show that systemic delivery of nanoparticle-formulated 1 methylpseudouridine-modified messenger RNA (m1Ψ mRNA) coding for

    更新日期:2021-01-07
  • Anterior cingulate inputs to nucleus accumbens control the social transfer of pain and analgesia
    Science (IF 41.845) Pub Date : 2021-01-08
    Monique L. Smith, Naoyuki Asada, Robert C. Malenka

    Empathy is an essential component of social communication that involves experiencing others’ sensory and emotional states. We observed that a brief social interaction with a mouse experiencing pain or morphine analgesia resulted in the transfer of these experiences to its social partner. Optogenetic manipulations demonstrated that the anterior cingulate cortex (ACC) and its projections to the nucleus

    更新日期:2021-01-07
  • Crossover from hydrogen to chemical bonding
    Science (IF 41.845) Pub Date : 2021-01-08
    Bogdan Dereka, Qi Yu, Nicholas H. C. Lewis, William B. Carpenter, Joel M. Bowman, Andrei Tokmakoff

    Hydrogen bonds (H-bonds) can be interpreted as a classical electrostatic interaction or as a covalent chemical bond if the interaction is strong enough. As a result, short strong H-bonds exist at an intersection between qualitatively different bonding descriptions, with few experimental methods to understand this dichotomy. The [F-H-F]− ion represents a bare short H-bond, whose distinctive vibrational

    更新日期:2021-01-07
  • Carbonaceous chondrite meteorites experienced fluid flow within the past million years
    Science (IF 41.845) Pub Date : 2021-01-08
    Simon Turner, Lucy McGee, Munir Humayun, John Creech, Brigitte Zanda

    Carbonaceous chondritic meteorites are primordial Solar System materials and a source of water delivery to Earth. Fluid flow on the parent bodies of these meteorites is known to have occurred very early in Solar System history (first <4 million years). We analyze short-lived uranium isotopes in carbonaceous chondrites, finding excesses of 234-uranium over 238-uranium and 238-uranium over 230-thorium

    更新日期:2021-01-07
  • Lithium pollution of a white dwarf records the accretion of an extrasolar planetesimal
    Science (IF 41.845) Pub Date : 2021-01-08
    B. C. Kaiser, J. C. Clemens, S. Blouin, P. Dufour, R. J. Hegedus, J. S. Reding, A. Bédard

    Tidal disruption and subsequent accretion of planetesimals by white dwarfs can reveal the elemental abundances of rocky bodies in exoplanetary systems. Those abundances provide information on the composition of the nebula from which the systems formed, which is analogous to how meteorite abundances inform our understanding of the early Solar System. We report the detection of lithium, sodium, potassium

    更新日期:2021-01-07
  • Transmission of SARS-CoV-2 on mink farms between humans and mink and back to humans
    Science (IF 41.845) Pub Date : 2021-01-08
    Bas B. Oude Munnink, Reina S. Sikkema, David F. Nieuwenhuijse, Robert Jan Molenaar, Emmanuelle Munger, Richard Molenkamp, Arco van der Spek, Paulien Tolsma, Ariene Rietveld, Miranda Brouwer, Noortje Bouwmeester-Vincken, Frank Harders, Renate Hakze-van der Honing, Marjolein C. A. Wegdam-Blans, Ruth J. Bouwstra, Corine GeurtsvanKessel, Annemiek A. van der Eijk, Francisca C. Velkers, Lidwien A. M. Smit

    Animal experiments have shown that nonhuman primates, cats, ferrets, hamsters, rabbits, and bats can be infected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In addition, SARS-CoV-2 RNA has been detected in felids, mink, and dogs in the field. Here, we describe an in-depth investigation using whole-genome sequencing of outbreaks on 16 mink farms and the humans living or working

    更新日期:2021-01-07
  • Microbial sulfate reduction and organic sulfur formation in sinking marine particles
    Science (IF 41.845) Pub Date : 2021-01-08
    M. R. Raven, R. G. Keil, S. M. Webb

    Climate change is driving an expansion of marine oxygen-deficient zones, which may alter the global cycles of carbon, sulfur, nitrogen, and trace metals. Currently, however, we lack a full mechanistic understanding of how oxygen deficiency affects organic carbon cycling and burial. Here, we show that cryptic microbial sulfate reduction occurs in sinking particles from the eastern tropical North Pacific

    更新日期:2021-01-07
  • Pre–T cell receptors topologically sample self-ligands during thymocyte β-selection
    Science (IF 41.845) Pub Date : 2021-01-08
    Xiaolong Li, Réka Mizsei, Kemin Tan, Robert J. Mallis, Jonathan S. Duke-Cohan, Aoi Akitsu, Paul W. Tetteh, Abhinav Dubey, Wonmuk Hwang, Gerhard Wagner, Matthew J. Lang, Haribabu Arthanari, Jia-huai Wang, Ellis L. Reinherz

    Self-discrimination, a critical but ill-defined molecular process programmed during thymocyte development, requires myriad pre–T cell receptors (preTCRs) and αβTCRs. Using x-ray crystallography, we show how a preTCR applies the concave β-sheet surface of its single variable domain (Vβ) to “horizontally” grab the protruding MHC α2-helix. By contrast, αβTCRs purpose all six complementarity-determining

    更新日期:2021-01-07
  • A ubiquitous tire rubber–derived chemical induces acute mortality in coho salmon
    Science (IF 41.845) Pub Date : 2021-01-08
    Zhenyu Tian, Haoqi Zhao, Katherine T. Peter, Melissa Gonzalez, Jill Wetzel, Christopher Wu, Ximin Hu, Jasmine Prat, Emma Mudrock, Rachel Hettinger, Allan E. Cortina, Rajshree Ghosh Biswas, Flávio Vinicius Crizóstomo Kock, Ronald Soong, Amy Jenne, Bowen Du, Fan Hou, Huan He, Rachel Lundeen, Alicia Gilbreath, Rebecca Sutton, Nathaniel L. Scholz, Jay W. Davis, Michael C. Dodd, Andre Simpson, Jenifer K

    In U.S. Pacific Northwest coho salmon (Oncorhynchus kisutch), stormwater exposure annually causes unexplained acute mortality when adult salmon migrate to urban creeks to reproduce. By investigating this phenomenon, we identified a highly toxic quinone transformation product of N-(1,3-dimethylbutyl)-N′-phenyl-p-phenylenediamine (6PPD), a globally ubiquitous tire rubber antioxidant. Retrospective analysis

    更新日期:2021-01-07
  • A broadly protective antibody that targets the flavivirus NS1 protein
    Science (IF 41.845) Pub Date : 2021-01-08
    Naphak Modhiran, Hao Song, Lidong Liu, Cheryl Bletchly, Lou Brillault, Alberto A. Amarilla, Xiaoying Xu, Jianxun Qi, Yan Chai, Stacey T. M. Cheung, Renee Traves, Yin Xiang Setoh, Summa Bibby, Connor A. P. Scott, Morgan E. Freney, Natalee D. Newton, Alexander A. Khromykh, Keith J. Chappell, David A. Muller, Katryn J. Stacey, Michael J. Landsberg, Yi Shi, George F. Gao, Paul R. Young, Daniel Watterson

    There are no approved flaviviral therapies and the development of vaccines against flaviruses has the potential of being undermined by antibody-dependent enhancement (ADE). The flavivirus nonstructural protein 1 (NS1) is a promising vaccine antigen with low ADE risk but has yet to be explored as a broad-spectrum therapeutic antibody target. Here, we provide the structural basis of NS1 antibody cross-reactivity

    更新日期:2021-01-07
  • Structural basis for antibody inhibition of flavivirus NS1–triggered endothelial dysfunction
    Science (IF 41.845) Pub Date : 2021-01-08
    Scott B. Biering, David L. Akey, Marcus P. Wong, W. Clay Brown, Nicholas T. N. Lo, Henry Puerta-Guardo, Francielle Tramontini Gomes de Sousa, Chunling Wang, Jamie R. Konwerski, Diego A. Espinosa, Nicholas J. Bockhaus, Dustin R. Glasner, Jeffrey Li, Sophie F. Blanc, Evan Y. Juan, Stephen J. Elledge, Michael J. Mina, P. Robert Beatty, Janet L. Smith, Eva Harris

    Medically important flaviviruses cause diverse disease pathologies and collectively are responsible for a major global disease burden. A contributing factor to pathogenesis is secreted flavivirus nonstructural protein 1 (NS1). Despite demonstrated protection by NS1-specific antibodies against lethal flavivirus challenge, the structural and mechanistic basis remains unknown. Here, we present three crystal

    更新日期:2021-01-07
  • Coordination between microbiota and root endodermis supports plant mineral nutrient homeostasis
    Science (IF 41.845) Pub Date : 2021-01-08
    Isai Salas-González, Guilhem Reyt, Paulina Flis, Valéria Custódio, David Gopaulchan, Niokhor Bakhoum, Tristan P. Dew, Kiran Suresh, Rochus Benni Franke, Jeffery L. Dangl, David E. Salt, Gabriel Castrillo

    Plant roots and animal guts have evolved specialized cell layers to control mineral nutrient homeostasis. These layers must tolerate the resident microbiota while keeping homeostatic integrity. Whether and how the root diffusion barriers in the endodermis, which are critical for the mineral nutrient balance of plants, coordinate with the microbiota is unknown. We demonstrate that genes controlling

    更新日期:2021-01-07
  • Recapitulation of HIV-1 Env-antibody coevolution in macaques leading to neutralization breadth
    Science (IF 41.845) Pub Date : 2021-01-08
    Ryan S. Roark, Hui Li, Wilton B. Williams, Hema Chug, Rosemarie D. Mason, Jason Gorman, Shuyi Wang, Fang-Hua Lee, Juliette Rando, Mattia Bonsignori, Kwan-Ki Hwang, Kevin O. Saunders, Kevin Wiehe, M. Anthony Moody, Peter T. Hraber, Kshitij Wagh, Elena E. Giorgi, Ronnie M. Russell, Frederic Bibollet-Ruche, Weimin Liu, Jesse Connell, Andrew G. Smith, Julia DeVoto, Alexander I. Murphy, Jessica Smith, Wenge

    Neutralizing antibodies elicited by HIV-1 coevolve with viral envelope proteins (Env) in distinctive patterns, in some cases acquiring substantial breadth. We report that primary HIV-1 envelope proteins—when expressed by simian-human immunodeficiency viruses in rhesus macaques—elicited patterns of Env-antibody coevolution very similar to those in humans, including conserved immunogenetic, structural

    更新日期:2021-01-07
  • Tubulin glycylation controls axonemal dynein activity, flagellar beat, and male fertility
    Science (IF 41.845) Pub Date : 2021-01-08
    Sudarshan Gadadhar, Gonzalo Alvarez Viar, Jan Niklas Hansen, An Gong, Aleksandr Kostarev, Côme Ialy-Radio, Sophie Leboucher, Marjorie Whitfield, Ahmed Ziyyat, Aminata Touré, Luis Alvarez, Gaia Pigino, Carsten Janke

    Posttranslational modifications of the microtubule cytoskeleton have emerged as key regulators of cellular functions, and their perturbations have been linked to a growing number of human pathologies. Tubulin glycylation modifies microtubules specifically in cilia and flagella, but its functional and mechanistic roles remain unclear. In this study, we generated a mouse model entirely lacking tubulin

    更新日期:2021-01-07
  • Making sense of neural development by comparing wiring strategies for seeing and hearing
    Science (IF 41.845) Pub Date : 2021-01-08
    A. A. Sitko, L. V. Goodrich

    The ability to perceive and interact with the world depends on a diverse array of neural circuits specialized for carrying out specific computations. Each circuit is assembled using a relatively limited number of molecules and common developmental steps, from cell fate specification to activity-dependent synaptic refinement. Given this shared toolkit, how do individual circuits acquire their characteristic

    更新日期:2021-01-07
  • Mechanism of spliceosome remodeling by the ATPase/helicase Prp2 and its coactivator Spp2
    Science (IF 41.845) Pub Date : 2021-01-08
    Rui Bai, Ruixue Wan, Chuangye Yan, Qi Jia, Jianlin Lei, Yigong Shi

    Spliceosome remodeling, executed by conserved adenosine triphosphatase (ATPase)/helicases including Prp2, enables precursor messenger RNA (pre-mRNA) splicing. However, the structural basis for the function of the ATPase/helicases remains poorly understood. Here, we report atomic structures of Prp2 in isolation, Prp2 complexed with its coactivator Spp2, and Prp2-loaded activated spliceosome and the

    更新日期:2021-01-07
  • Immunological memory to SARS-CoV-2 assessed for up to 8 months after infection
    Science (IF 41.845) Pub Date : 2021-01-07
    Jennifer M. Dan, Jose Mateus, Yu Kato, Kathryn M. Hastie, Esther Dawen Yu, Caterina E. Faliti, Alba Grifoni, Sydney I. Ramirez, Sonya Haupt, April Frazier, Catherine Nakao, Vamseedhar Rayaprolu, Stephen A. Rawlings, Bjoern Peters, Florian Krammer, Viviana Simon, Erica Ollmann Saphire, Davey M. Smith, Daniela Weiskopf, Alessandro Sette, Shane Crotty

    Understanding immune memory to SARS-CoV-2 is critical for improving diagnostics and vaccines, and for assessing the likely future course of the COVID-19 pandemic. We analyzed multiple compartments of circulating immune memory to SARS-CoV-2 in 254 samples from 188 COVID-19 cases, including 43 samples at ≥ 6 months post-infection. IgG to the Spike protein was relatively stable over 6+ months. Spike-specific

    更新日期:2021-01-07
Contents have been reproduced by permission of the publishers.
导出
全部期刊列表>>
微生物研究
亚洲大洋洲地球科学
NPJ欢迎投稿
自然科研论文编辑
ERIS期刊投稿
欢迎阅读创刊号
自然职场,为您触达千万科研人才
spring&清华大学出版社
城市可持续发展前沿研究专辑
Springer 纳米技术权威期刊征稿
全球视野覆盖
施普林格·自然新
chemistry
物理学研究前沿热点精选期刊推荐
自然职位线上招聘会
欢迎报名注册2020量子在线大会
化学领域亟待解决的问题
材料学研究精选新
GIANT
ACS ES&T Engineering
ACS ES&T Water
屿渡论文,编辑服务
阿拉丁试剂right
上海中医药大学
浙江大学
西湖大学
化学所
北京大学
清华
隐藏1h前已浏览文章
课题组网站
新版X-MOL期刊搜索和高级搜索功能介绍
ACS材料视界
清华大学-1
武汉大学
浙江大学
天合科研
x-mol收录
试剂库存
down
wechat
bug