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Isoliquiritigenin Mitigates Oxidative Damage after Subarachnoid Hemorrhage In Vivo and In Vitro by Regulating Nrf2-dependent Signaling Pathway via Targeting of SIRT1 Phytomedicine (IF 5.34) Pub Date : 2022-06-21 Jia-Qiang Liu, Xin-Tong Zhao, Fei-Yun Qin, Jia-Wang Zhou, Fei Ding, Gang Zhou, Xiang-Sheng Zhang, Zi-Huan Zhang, Zhen-Bao Li
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Biodistribution and pharmacokinetic profile of berberine and its metabolites in hepatocytes Phytomedicine (IF 5.34) Pub Date : 2022-06-19 Xiaomei Liu, Wenfang Li, Han Zhang, Xiaoming Wang, Yuhong Huang, Yuhong Li, Guixiang Pan
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Astragaloside Ⅳ alleviates ulcerative colitis by regulating the balance of Th17/Treg cells Phytomedicine (IF 5.34) Pub Date : 2022-06-19 Youbao Zhong, Wenjun Liu, Yanxia Xiong, Yingmeng Li, Qi Wan, Wen Zhou, Haimei Zhao, Qiuping Xiao, Duanyong Liu
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Tetrahydrocurcumin improves lipopolysaccharide-induced myocardial dysfunction by inhibiting oxidative stress and inflammation via JNK/ERK signaling pathway regulation Phytomedicine (IF 5.34) Pub Date : 2022-06-18 Hanzhao Zhu, Liyun Zhang, Hao Jia, Lu Xu, Yu Cao, Mengen Zhai, Kaifeng Li, Lin Xia, Liqing Jiang, Xiang Li, Yenong Zhou, Jincheng Liu, Shiqiang Yu, Weixun Duan
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5-Demethylnobiletin: Insights into Its Pharmacological Activity, Mechanisms, Pharmacokinetics and Toxicity Phytomedicine (IF 5.34) Pub Date : 2022-06-18 Haiyan Ding, Qiang You, Dan Li, Youping Liu
Background : 5-Demethylnobiletin (5DN) is a polymethoxyflavone (PMF) primarily found in citrus fruits. It has various health-promoting properties and hence has attracted significant attention from scholars worldwide. Purpose : This review is the first to systematically summarize the recent research progress of 5DN, including its pharmacological activity, mechanism of action, pharmacokinetics, and toxicological
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Efficacy and safety of micronized purified flavonoid fractions for the treatment of postoperative hemorrhoid complications: A systematic review and meta-analysis Phytomedicine (IF 5.34) Pub Date : 2022-06-17 Haiqi Fu, Wenfang Guo, Baochang Zhou, Yibo Liu, Yuan Gao, Minhui Li
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Mangiferin, a natural glucoxilxanthone, inhibits mitochondrial dynamin-related protein 1 and relieves aberrant mitophagic proteins in mice model of Parkinson's disease Phytomedicine (IF 5.34) Pub Date : 2022-06-16 Xiao-Le Wang, Si-Tong Feng, Ya-Ting Wang, Ning-Ning Zhang, Zhen-Yu Guo, Xu Yan, Yu-He Yuan, Zhen-Zhen Wang, Nai-Hong Chen, Yi Zhang
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Portulaca oleracea extract reduces gut microbiota imbalance and inhibits colorectal cancer progression via inactivation of the Wnt/β-catenin signaling pathway Phytomedicine (IF 5.34) Pub Date : 2022-06-16 Shengen Yi, Xiaoxin Jin, Bo Liu, Peidong Wu, Wang Xiao, Weidong Chen
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Celastrol upregulated ATG7 triggers autophagy via targeting Nur77 in colorectal cancer Phytomedicine (IF 5.34) Pub Date : 2022-06-16 Wenxin Zhang, Zimei Wu, Huijie Qi, Lu Chen, Tianxiao Wang, Xiang Mao, Huanying Shi, Haifei Chen, Mingkang Zhong, Xiaojin Shi, Xinhai Wang, Qunyi Li
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Clinical effectiveness of Qilong capsule in patients with ischemic stroke: A prospective, multicenter, non-randomized controlled trial Phytomedicine (IF 5.34) Pub Date : 2022-06-15 Jian Lyu, Yang Gao, Ruili Wei, Yefeng Cai, Xiaoming Shen, Dexi Zhao, Xingquan Zhao, Yingzhen Xie, Haiqing Yu, Yan Chai, Yanming Xie
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Suo Quan Wan ameliorates bladder overactivity and regulates neurotransmission via regulating Myosin Va protein expression Phytomedicine (IF 5.34) Pub Date : 2022-06-15 Yao Zhang, Jiao Zhang, Ming Hong, Jingyi Huang, Siyuan Xu, Rui Wang, Na Zhou, Ping Huang, Bo Tan, Hongying Cao
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A systematic review and meta-analysis for the primary prevention of high risk of stroke by Nao-an capsules Phytomedicine (IF 5.34) Pub Date : 2022-06-15 Liuding Wang, Xueming Fan, Wanqing Du, Xiao Liang, Yifan Chen, Jingzi Shi, Linjuan Sun, Wei Shen, Yunling Zhang
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Calycosin Reduces Myocardial Fibrosis and Improves Cardiac Function in Post-Myocardial Infarction Mice by Suppressing TGFBR1 Signaling Pathways Phytomedicine (IF 5.34) Pub Date : 2022-06-15 Guanghong Chen, Honglin Xu, Tong Xu, Wenjun Ding, Guoyong Zhang, Yue Hua, Yuting Wu, Xin Han, Lingpeng Xie, Bin Liu, Yingchun Zhou
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Artemisia Leaf Extract protects against neuron toxicity by TRPML1 activation and promoting autophagy/mitophagy clearance in both in vitro and in vivo models of MPP+/MPTP-induced Parkinson's disease Phytomedicine (IF 5.34) Pub Date : 2022-06-15 Li-Kung Wu, Surbhi Agarwal, Chia-Hua Kuo, Yen-Lun Kung, Cecilia Hsuan Day, Pi-Yu Lin, Shinn-Zong Lin, Dennis Jine-Yuan Hsieh, Chih-Yang Huang, Chien-Yi Chiang
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LC-MS-based metabolomics reveals metabolic changes in short- and long-term administration of Compound Danshen Dripping Pills against acute myocardial infarction in rats Phytomedicine (IF 5.34) Pub Date : 2022-06-12 Lu Zhang, Ling-Ling Wang, Hao Zeng, Bin Li, Hua Yang, Guang-Ji Wang, Ping Li
Background Mild and systematically improving multiple metabolic disorders was a focused view for Compound Danshen Dripping Pills playing synergistic effects through multiple components and multiple targets. The difference in overall therapeutic effects and endogenous metabolic regulation between short- and long-term administration was still unclear. Purpose This study aimed to explore the difference
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Electrochemical-based quantitative fingerprint evaluation strategy combined with multi-markers assay by monolinear method for quality control of herbal medicine Phytomedicine (IF 5.34) Pub Date : 2022-06-12 Dandan Gong, Xiang Li, Xinrong Liu, Guoxiang Sun, Ping Guo
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Kinsenoside alleviates inflammation and fibrosis in experimental NASH mice by suppressing the NF-κB/NLRP3 signaling pathway Phytomedicine (IF 5.34) Pub Date : 2022-06-15 Yan-fang Deng, Qian-qian Xu, Tian-qi Chen, Jia-xiong Ming, Ya-fen Wang, Li-na Mao, Jia-jun Zhou, Wei-guang Sun, Qun Zhou, Hong Ren, Yong-hui Zhang
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China Rheumatoid Arthritis Registry of Patients with Chinese Medicine (CERTAIN): Rationale, Design, and Baseline Characteristics of the First 11764 Enrollees Phytomedicine (IF 5.34) Pub Date : 2022-06-14 Xun Gong, Wei-xiang Liu, Da Li, Qiu-wei Peng, Cong-min Xia, Tian Chang, Jin-zhi Guan, Meng-ge Song, Fu-yuan Zhang, Xiao-po Tang, Ying Liu, Jian Liu, Jiang-yun Peng, Dong-yi He, Qing-chun Huang, Ming-li Gao, Jian-ping Yu, Wei Liu, Quan Jiang
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Simiao Wan modulates the gut microbiota and bile acid metabolism during improving type 2 diabetes mellitus in mice Phytomedicine (IF 5.34) Pub Date : 2022-06-13 Yimeng Chen, Lijuan Zhu, Wenxin Hu, Yuping Wang, Xiaodong Wen, Jie Yang
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Danshensu prevents thrombosis by inhibiting platelet activation via SIRT1/ROS/mtDNA pathways without increasing bleeding risk Phytomedicine (IF 5.34) Pub Date : 2022-06-12 Yuejin Xue, Liyuan Zhang, Lusha Zhang, Wei Sun, Zhirui Fang, Yuze Leng, Mengyao Li, Xiuyun Ren, Rui Zhang, Yingxue Zhang, Lu Chen, Hong Wang
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Flavonoids from Rhododendron nivale Hook. f delay aging via modulation of gut microbiota and glutathione metabolism Phytomedicine (IF 5.34) Pub Date : 2022-06-12 Xiao Guo, Zhen Dong, Qien Li, Digao Wan, Jiangbin Zhong, Duojie Dongzhi, Meizhou Huang
Background : Rhododendron nivale Hook. f (R.n), one of the four Manna Stash used in Tibetan medicine to delay aging, possesses anti-aging pharmacological activity. However, which R.n ingredients contain anti-aging properties and the underlying mechanisms involved are unclear. Hypothesis/Purpose Based on interactions between gut microbiota and natural medicines and the important role of gut microbiota
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A multidimensional strategy for uncovering comprehensive quality markers of Schisandra chinensis (Turcz.) Baill based on pharmacodynamics and chemical properties Phytomedicine (IF 5.34) Pub Date : 2022-06-12 Yiwen Zhang, Saiyu Li, Panpan Yang, Qian Zhang, Huarong Xu, Kaishun Bi, Qing Li
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Induction of P-glycoprotein expression by dandelion in tumor and heart tissues: Impact on the anti-tumor activity and cardiotoxicity of doxorubicin Phytomedicine (IF 5.34) Pub Date : 2022-06-12 Jiameng Qu, Fan Ke, Xiao Yang, Yue Wang, Huarong Xu, Qing Li, Kaishun Bi
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Network pharmacology provides a systematic approach to understanding the treatment of ischemic heart diseases with traditional Chinese medicine Phytomedicine (IF 5.34) Pub Date : 2022-06-12 Hua-Yi Yang, Men-Lan Liu, Pei Luo, Xin-Sheng Yao, Hua Zhou
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Acupuncture for de Quervain's tenosynovitis: A randomized controlled trial Phytomedicine (IF 5.34) Pub Date : 2022-06-14 Kinking Leung, Oliver Chunho Ma, Zongshi Qin, Ho Ting, Andrew Hokay Lau, Kevin Kaifung Lun, Hanna Yufaye Chan, Grace Yagun Wen, Jetson Tszkit Ng, Lingfung Chow, Cody Yuenting Chu, Tracy Siuting Ho, Katherine Tsang, Bacon Fung Leung Ng, Margaret Woon Man Fok, Christian Xin Shuo Fang, Lixing Lao, Haiyong Chen
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Diosgenin protects against podocyte injury in early phase of diabetic nephropathy through regulating SIRT6 Phytomedicine (IF 5.34) Pub Date : 2022-06-13 Zhi Wang, Qiao Wu, Hongzhan Wang, Yang Gao, Kexin Nie, Yueheng Tang, Hao Su, Meilin Hu, Jing Gong, Ke Fang, Hui Dong
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Extract of Murraya koenigii selectively causes genomic instability by altering redox-status via targeting PI3K/AKT/Nrf2/caspase-3 signaling pathway in human non-small cell lung cancer Phytomedicine (IF 5.34) Pub Date : 2022-06-13 Priya Mondal, Jagadish Natesh, Dhanamjai Penta, Syed Musthapa Meeran
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Shuanghua decoction exerts anticancer activity by activating NLRP3 inflammasome via ROS and inhibiting NF-κB signaling in hepatocellular carcinoma cells Phytomedicine (IF 5.34) Pub Date : 2022-06-10 Bingling Dai, Mengying Fan, Xiaoyue Huang, Zhengyan Gong, Hanbing Cao, Yu Hu, Qi Su, Tianfeng Yang, Yanbin Chen, Xiujuan Peng, Feng Liu, Yanmin Zhang
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Autophagy activation by Terminalia chebula Retz. reduce Aβ generation by shifting APP processing toward non-amyloidogenic pathway in APPswe transgenic SH-SY5Y cells Phytomedicine (IF 5.34) Pub Date : 2022-06-06 Longhe Zhao, Zhaorong Yue, Yanni Wang, Jiatao Wang, Inam Ullah, Fahim Muhammad, Yongtao Zhou, Hongmei Zhu, Xin Wang, Hongyu Li
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Lycorine and organ protection: Review of its potential effects and molecular mechanisms Phytomedicine (IF 5.34) Pub Date : 2022-06-09 Haoxiang Xiao, Xuezeng Xu, Luyang Du, Xiyang Li, Huadong Zhao, Zheng Wang, Lin Zhao, Zhi Yang, Shaofei Zhang, Yang Yang, Changyu Wang
Background : Multiorgan dysfunction, especially sepsis-related multiorgan damage, remains a major cause of high mortality in the late stages of infection and a great clinical challenge. In recent years, natural drugs have received widespread attention because of their low cost, wide sources, high efficacy, low toxicity, and limited side effects. Lycorine, a natural compound extracted from Amaryllidaceae
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Activation of farnesoid X receptor signaling by geniposidic acid promotes osteogenesis Phytomedicine (IF 5.34) Pub Date : 2022-06-09 Meijing Liu, Fujun Jin, Shuai Zhang, Shuang Li, Danqi Zhu, Yi Cui, Mingxiang Cai, Xiangning Liu, Yongbiao Zhang, Yao Sun, Changhui Liu, Xiaogang Wang
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Single-cell transcriptomics reveals the natural product Shi-Bi-Man promotes hair regeneration by activating the FGF pathway in dermal papilla cells Phytomedicine (IF 5.34) Pub Date : 2022-06-09 Mingrui Han, Chengxi Li, Chenyang Zhang, Chenglin Song, Qiang Xu, Qianqian Liu, Jianming Guo, Yang Sun
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Effects of Xinkeshu tablets on coronary heart disease patients combined with anxiety and depression symptoms after percutaneous coronary intervention: A meta-analysis Phytomedicine (IF 5.34) Pub Date : 2022-06-10 Mingtai Chen, Mengnan Liu, Xin Guo, Jie Zhou, Huayi Yang, Guofu Zhong, Ling Men, Ying Xie, Guangdong Tong, Qiang Liu, Jienan Luan, Hua Zhou
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Global analysis of qualitative and quantitative metabolism of Notoginsenoside R1 in rat liver-brain-gut axis based on LC-IT-TOF/MS combing mMDF strategy Phytomedicine (IF 5.34) Pub Date : 2022-06-08 Kangrui Hu, Changjian Li, Tengjie Yu, Huimin Guo, Hong Sun, Shuying Mao, Zhihao Zhou, Wei Jin, Keanqi Liu, Lin Xie, Guangji Wang, Yan Liang
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Caffeic acid phenethyl ester alleviated hypouricemia in hyperuricemic mice through inhibiting XOD and up-regulating OAT3 Phytomedicine (IF 5.34) Pub Date : 2022-06-08 Tianqiao Yong, Danling Liang, Shaodan Chen, Chun Xiao, Xiong Gao, Qingping Wu, Yizhen Xie, Longhua Huang, Huiping Hu, Xiangmin Li, Yuancao Liu, Manjun Cai
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Iristectorigenin A exerts novel protective properties against airway inflammation and mucus hypersecretion in OVA-induced asthmatic mice Phytomedicine (IF 5.34) Pub Date : 2022-06-08 Tulake Wuniqiemu, Fangzhou Teng, Jingjing Qin, Yubao lv, Mohammadtursun Nabijan, Qingli Luo, Yaolong Zhou, Jie Cui, La Yi, Weifeng Tang, Xueyi Zhu, Amangu, Shiyuan Wang, Muhammadjan Abduwaki, Mammat Nurahmat, Ying Wei, Jing cheng Dong
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Metabolomic analysis of Gyejibongnyeong-Hwan for shoulder pain: A randomized, wait-list controlled pilot trial Phytomedicine (IF 5.34) Pub Date : 2022-06-09 Mi Mi Ko, Jeeyoun Jung, Jung-Eun Lee, Seon Mi Shin, Hyun-Kyung Sung, Ho-Yeon Go, Soobin Jang
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Aristolone in Nardostachys jatamansi DC. induces mesenteric vasodilation and ameliorates hypertension via activation of the KATP channel and PDK1-Akt-eNOS pathway Phytomedicine (IF 5.34) Pub Date : 2022-06-09 Jingmei Fang, Ran Li, Yue Zhang, Patrick Kwabena Oduro, Sa Li, Ling Leng, Zhimei Wang, Yao Rao, Lu Niu, Hong-Hua Wu, Qilong Wang
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Real-world data on herb-drug interactions in oncology: a scoping review of pharmacoepidemiological studies Phytomedicine (IF 5.34) Pub Date : 2022-06-07 Chun Sing Lam, Ho Kee Koon, Chung Tin Ma, Kwok Yin Au, Zhong Zuo, Vincent Chi-Ho Chung, Yin Ting Cheung
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Market access for Chinese herbal medicinal products in Europe—A ten-year review of relevant products, policies, and challenges Phytomedicine (IF 5.34) Pub Date : 2022-06-03 Yin Xiong, Minghui Li, Pengyue Sun, Wen Liang, Ryan G. Hornbeck, Xiaoyan Che, Cheng Rao, Ye Zhao, Liqun Guo, Yan Huang, Hua Yang, Ping Li, Burt H. Kroes, Xiuming Cui, Gerhard Franz, Mei Wang
Background With increased consumer demand in Europe for natural and efficacious health products, the use of herbal products in the market is rising. Products of Chinese herbal medicine (CHM) could greatly expand European consumer options; however, only seven herbal medicinal products (HMPs) based on CHM formulae have been registered in the European Union (EU) since 2012. Purpose This study reviews
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Kaempferol Inhibits Renal Fibrosis by Suppression of the Sonic Hedgehog Signaling Pathway Phytomedicine (IF 5.34) Pub Date : 2022-06-06 Yiqing Guan, Dongling Quan, Kai Chen, Liangqi Kang, Danni Yang, Huanxian Wu, Mengqiu Yan, Shaoyu Wu, Lin LV, Guohua Zhang
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Berberine suppresses colorectal cancer by regulation of Hedgehog signaling pathway activity and gut microbiota Phytomedicine (IF 5.34) Pub Date : 2022-06-02 Qiang Sun, Han Yang, Maolun Liu, Shan Ren, Hui Zhao, Tianqi Ming, Shun Tang, Qiu Tao, Li Chen, Sha Zeng, Dayue Darrel Duan, Haibo Xu
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Triterpenoid saponins from Ilex pubescens promote blood circulation in blood stasis syndrome by regulating sphingolipid metabolism and the PI3K/AKT/eNOS signaling pathway Phytomedicine (IF 5.34) Pub Date : 2022-06-06 Jie Chen, Di Cao, Shiqin Jiang, Xia Liu, Wencong Pan, Hui Cui, Weiqun Yang, Zhongqiu Liu, Jing Jin, Zhongxiang Zhao
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Effects of Echinocystic Acid on Atopic Dermatitis and Allergic Inflammation of the Skin and Lungs Phytomedicine (IF 5.34) Pub Date : 2022-06-06 Yun-Mi Kang, Hye-Min Kim, Minho Lee, Hyo-Jin An
Background Echinocystic acid (ECA), a pentacyclic triterpene enriched in various herbs, promotes anti-inflammatory and antioxidant activity; however, its therapeutic effects on atopic dermatitis (AD) or atopic march and the underlying mechanisms of action have not yet been fully elucidated. Purpose This study aimed to elucidate the effects and molecular mechanisms of ECA on AD and allergic inflammation
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β-Lapachone, an NQO1 activator, alleviates diabetic cardiomyopathy by regulating antioxidant ability and mitochondrial function Phytomedicine (IF 5.34) Pub Date : 2022-06-06 Pei-Yu Wu, Shin-Yu Lai, Yi-Ting Su, Kai-Chien Yang, Yat-Pang Chau, Ming-Jaw Don, Kai-Hsi Lu, Horng-Tzer Shy, Shu-Mei Lai, Hsiu-Ni Kung
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The extract of Polygala fallax Hemsl. slows the progression of diabetic nephropathy by targeting TLR4 anti-inflammation and MMP-2/9-mediated anti-fibrosis in vitro Phytomedicine (IF 5.34) Pub Date : 2022-06-06 Minhui Wang, Xinyan Liu, Zelong Wang, Qin Xu
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The secretion of sIgA and dendritic cells activation in the intestinal of cyclophosphamide-induced immunosuppressed mice are regulated by Alhagi honey polysaccharides Phytomedicine (IF 5.34) Pub Date : 2022-06-01 Gaofeng Cai, Yang Yang, Pengfei Gu, Kui Li, Wusiman Adelijiang, Tianyu Zhu, Zhenguang Liu, Deyun Wang
Background It remains a huge challenge to recover the intestine immune function for the treatment of intestinal mucosal damage from chemotherapy with cyclophosphamide (CY). Alhagi honey polysaccharide (AH) has immunomodulation pharmacological activity, but the effect and mechanism on the intestinal immune system of CY-mice remain unclear. Purpose In this experiment, the immunomodulatory activity of
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Ursolic acid inhibits the cholesterol biosynthesis and alleviates high fat diet-induced hypercholesterolemia via irreversible inhibition of HMGCS1 in vivo Phytomedicine (IF 5.34) Pub Date : 2022-06-01 Xiaoyao Ma, Yongping Bai, Kaixin Liu, Yiman Han, Jinling Zhang, Yuteng Liu, Xiaotao Hou, Erwei Hao, Yuanyuan Hou, Gang Bai
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Dioscin alleviates myocardial infarction injury via regulating BMP4/NOX1-mediated oxidative stress and inflammation Phytomedicine (IF 5.34) Pub Date : 2022-05-31 Zhe Zhang, Xuerong Zhao, Meng Gao, Lina Xu, Yan Qi, Jinhong Wang, Lianhong Yin
Background Dioscin, a steroidal saponin natural product, has various pharmacological activities, such as anti-inflammatory, antioxidant, lipid-lowering. However, little is known about its effects on myocardial infarction (MI) injury. Thus, the study aimed to investigate the protective effects and possible mechanisms of dioscin. Methods We evaluated protective effects of Dioscin on HL-1 cells after
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Qing-Xin-Jie-Yu Granule alleviates atherosclerosis by reshaping gut microbiota and metabolic homeostasis of ApoE-/- mice Phytomedicine (IF 5.34) Pub Date : 2022-06-01 Anlu Wang, Baoyi Guan, Chang Shao, Lin Zhao, Qiuyi Li, Haiping Hao, Zhuye Gao, Keji Chen, Yuanlong Hou, Hao Xu
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Phillygenin ameliorates nonalcoholic fatty liver disease via TFEB-mediated lysosome biogenesis and lipophagy Phytomedicine (IF 5.34) Pub Date : 2022-06-03 Wenling Zhou, Xu Yan, Yuanyuan Zhai, Hao Liu, Lingling Guan, Yuan Qiao, Jizhi Jiang, Liang Peng
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Xiaoyaosan inhibits neuronal apoptosis by regulating the miR-200/NR3C1 signalling in the prefrontal cortex of chronically stressed rats Phytomedicine (IF 5.34) Pub Date : 2022-06-03 Naijun Yuan, Xiaojuan Li, Kairui Tang, Hua Gan, Xiaoli Da, Wenzhi Hao, Lijuan Deng, Junqing Huang, Qingyu Ma, Mansi Wu, Jiaxu Chen
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Multiplex planar bioassay detecting estrogens, antiestrogens, false-positives and synergists as sharp zones on normal phase Phytomedicine (IF 5.34) Pub Date : 2022-06-02 A. Ronzheimer, T. Schreiner, G.E. Morlock
Background Phytoestrogens are found in many plants used in traditional medicines. Increasingly, plant extracts (botanicals) are also being added to foods or marketed as dietary supplements. Especially powder formulations are susceptible to adulteration and falsification, given the global processing chain. To detect estrogen-like compounds in such multicomponent mixtures, non-target screening for hormonally
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Phytochemistry and bioactivities of the main constituents of Polyporus umbellatus (Pers.) Fries Phytomedicine (IF 5.34) Pub Date : 2022-05-30 Di He, Yafei Ren, Xin Hua, Jiao Zhang, Bin Zhang, Juane Dong, Thomas Efferth, Pengda Ma
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Ascaridole exerts the leishmanicidal activity by inhibiting parasite glycolysis Phytomedicine (IF 5.34) Pub Date : 2022-06-03 Deblina Sarkar, Sritama De Sarkar, Lars Gille, Mitali Chatterjee
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Rhodiola crenulate alleviates hypobaric hypoxia-induced brain injury via adjusting NF-κB/NLRP3-mediated inflammation Phytomedicine (IF 5.34) Pub Date : 2022-06-03 Na Xie, Fangfang Fan, Shengnan Jiang, Ya Hou, Yi Zhang, Nanjia Cairang, Xiaobo Wang, Xianli Meng
Background Rhodiola crenulate (R. crenulate), a famous Tibetan medicine, has been demonstrated to possess superiorly protective effects in high-altitude hypoxic brain injury (HHBI). However, its mechanisms on HHBI are still largely unknown. Methods Herein, the protective effects and underlying mechanisms of R. crenulate on HHBI of BABL/c mice were explored through in vivo experiments. The mice model
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Tabersonine attenuates Angiotensin II-induced cardiac remodeling and dysfunction through targeting TAK1 and inhibiting TAK1-mediated cardiac inflammation Phytomedicine (IF 5.34) Pub Date : 2022-06-03 Chengyi Dai, Wu Luo, Yanghao Chen, Siyuan Shen, Zhe Wang, Ruijie Chen, Jun Wang, Nipon Chattipakorn, Weijian Huang, Guang Liang
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The anxiolytic effect of koumine on a predatory sound stress-induced anxiety model and its associated molecular mechanisms Phytomedicine (IF 5.34) Pub Date : 2022-06-03 Bojun Xiong, Zhifeng Zhong, Chaojie Chen, Huihui Huang, Jinxiang Lin, Ying Xu, Jian Yang, Changxi Yu
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Mass spectrometry-based profiling and imaging strategy, a fit-for-purpose tool for unveiling the transformations of ginsenosides in Panax notoginseng during processing Phytomedicine (IF 5.34) Pub Date : 2022-06-03 Wenxiang Fan, Yuangui Yang, Linnan Li, Linhong Fan, Zhengtao Wang, Li Yang
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Effect of modified Jianpi Yangzheng on regulating content of PKM2 in gastric cancer cells-derived exosomes Phytomedicine (IF 5.34) Pub Date : 2022-06-02 Jian Wu, Mengyun Yuan, Junyu Shen, Yuxuan Chen, Ruijuan Zhang, Xu Chen, Haidan Wang, Zhonghua Yin, Xingxing Zhang, Shenlin Liu, Qingmin Sun