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Inhibition of IRAK 1/4 alleviates colitis by inhibiting TLR4/ NF-κB pathway and protecting the intestinal barrier. Bosn. J. Basic Med. Sci. (IF 3.363) Pub Date : 2022-06-13 Bo Yan, Xiangjie Li, Linxiang Zhou, Yuqing Qiao, Jing Wu, Lanlan Zha, Peilu Liu, Shuai Peng, Baixin Wu, Xiaoyun Yu, Lei Shen
Interleukin-1 receptor-associated kinase 1/4 (IRAK1/4) is the main kinase of the Toll-like receptor (TLR)-mediated pathway, considered a new target for treating inflammatory diseases. Studies showed a significant correlation between TLRs and inflammatory responses in ulcerative colitis (UC). Therefore, in this study, after inducing experimental colitis in mice with 3% dextran sulfate sodium (DSS),
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IC50: an unsuitable measure for large-sized prostate cancer spheroids in drug sensitivity evaluation. Bosn. J. Basic Med. Sci. (IF 3.363) Pub Date : 2022-06-09 Yipeng Xu, Gabriela Pachnikova, He Wang, Yaoyao Wu, Dorothea Przybilla, Reinhold Schäfer, Zihao Chen, Shaoxing Zhu, Ulrich Keilholz
Preclinical models of tumors have the potential to become valuable tools for commercial drug research and development, and 3D culture systems are gaining attraction in this area, including prostate cancer (PCa) research. However, nearly all 3D drug design and screening assessments are based on 2D experiments, indicating the limitations of 3D drug testing. To simulate the natural response of human cells
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Prognostic and predictive significance of VEGF, CD31, and Ang-1 in patients with metastatic clear cell renal cell carcinoma treated with first-line sunitinib. Bosn. J. Basic Med. Sci. (IF 3.363) Pub Date : 2022-06-08 Marija Kraljević, Inga Marijanović, Maja Barbarić, Emir Sokolović, Merima Bukva, Timur Cerić, Teo Buhovac
The most common type of renal cell carcinoma (RCC) is clear cell renal cell carcinoma (ccRCC), which has a high metastatic potential. Even though the International Metastatic RCC Database Consortium (IMDC) risk model is conventionally utilized for selection and stratification of patients with metastatic RCC (mRCC), there remains an unmet demand for novel prognostic and predictive markers. The goal
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Predictors of COVID-19 severity among pregnant patients. Bosn. J. Basic Med. Sci. (IF 3.363) Pub Date : 2022-06-05 Marcin Januszewski, Laura Ziuzia-Januszewska, Alicja A Jakimiuk, Tomasz Oleksik, Marek Pokulniewicz, Waldemar Wierzba, Krzysztof Kozlowski, Artur J Jakimiuk
Coronavirus disease 2019 (COVID-19) was declared a pandemic and has spread around the globe, unsparingly affecting vulnerable populations. Effective prevention measures for pregnant women, who are particularly affected, include early identification of those patients at risk of developing in-hospital complications, and the continuous improvement of maternal-fetal treatment strategies to ensure the efficient
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Serum microRNAs as biomarkers for the diagnosis of papillary thyroid carcinoma: a meta-analysis. Bosn. J. Basic Med. Sci. (IF 3.363) Pub Date : 2022-06-04 Yuping Chen, Bingtian Dong, Lichun Huang, Huibin Huang
Papillary thyroid carcinoma (PTC) is the most common form of thyroid cancer. Several studies have proposed serum microRNAs (miRNAs) as novel biomarkers for diagnosing PTC. In this study, we conducted a meta-analysis aiming to investigate the overall diagnostic accuracy of serum miRNAs in PTC detection. Three online databases including PubMed, EMBASE and Cochrane Library were searched up to 1 May 2021
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Serum extracellular vesicle microRNA dysregulation and childhood trauma in adolescents with major depressive disorder. Bosn. J. Basic Med. Sci. (IF 3.363) Pub Date : 2022-06-03 Liu-Yi Ran, Yi-Ting Kong, Jiao-Jiao Xiang, Qi Zeng, Chen-Yu Zhang, Lei Shi, Hai-Tang Qiu, Chuan Liu, Lin-Li Wu, Ya-Lan Li, Jian-Mei Chen, Ming Ai, Wo Wang, Li Kuang
Major depressive disorder (MDD) seriously endangers adolescent mental and physical health. Extracellular vesicles (EVs) are mediators of cellular communication and are involved in many physiological brain processes. Although EV miRNAshave been implicated in adults with major psychiatric disorders, investigation into their effects in adolescent MDDremains scarce. In discovery set, we conducted a genome-wide
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Urine amylase level after Whipple resection might be a predictive factor of postoperative complications. Bosn. J. Basic Med. Sci. (IF 3.363) Pub Date : 2022-06-03 Farid Ljuca, Amir Tursunović, Kenana Ljuca, Zijah Rifatbegović, Mirha Agić
The association between urine amylase levels and the development of postoperative complications after Whipple resection is still unknown. Aim of this study was to determine the prognostic value of urine amylase levels for postoperative complications in patients who underwent Whipple resection. In this retrospective cohort study, we analyzed amylase levels in urine, serum and drains in 52 patients who
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Extent of clinical attachment loss as a practical parameter in efficacy of adjunctive photodynamic therapy in stage II - IV grade C Periodontitis (Aggressive periodontitis): A systematic review and meta-analysis. Bosn. J. Basic Med. Sci. (IF 3.363) Pub Date : 2022-05-29 Zahra Baghani, Samira Basir Shabestari, Malihe Karrabi
This systematic review and meta-analysis aimed to assess the extent of clinical attachment loss (CAL) as a clinical parameter in the efficacy of antimicrobial photodynamic therapy (aPDT) in non-surgical management of stage II-IV grade C molar-incisor pattern Periodontitis. This review protocol was conducted in accordance with PRISMA statements and is registered in PROSPERO (CRD42022321211). An electronic
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The first detection of Pneumocystis jirovecii in asthmatic patients post COVID-19 in Jordan. Bosn. J. Basic Med. Sci. (IF 3.363) Pub Date : 2022-05-17 Ahmad Riyad Alsayed, Wamidh Talib, Abdullah Al-Dulaimi, Safa Daoud, Mohammed Al Maqbali
Pneumocystis jirovecii pneumonia (PCP), caused by fungal species named Pneumocystis jirovecii, is a frequent opportunistic infection in those with human immunodeficiency virus (HIV) infection. However, PCP has been documented in immunocompetent patients. This study aims to determine if P. jirovecii detection occurs in asthma patients following coronavirus disease 2019 (COVID-19) in a Jordanian cohort
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Integrating abdominal plain radiographs and clinical data for neonatal necrotizing enterocolitis using hypergraph-based multi-constraint combined non-negative matrix factorization to construct a diagnostic model. Bosn. J. Basic Med. Sci. (IF 3.363) Pub Date : 2022-05-15 Guoqiang Qi, Shoujiang Huang, Dengming Lai, Jing Li, Yonggen Zhao, Chen Shen, Jian Huang, Tianmei Liu, Kai Wei, Jinfa Dou, Qiang Shu, Gang Yu
Neonatal necrotizing enterocolitis is a severe neonatal intestinal disease. Timely identification of surgical indications is essential for newborns in order to seek the best time for treatment and improve prognosis. This paper attempts to establish an algorithm model based on multimodal clinical data to determine the features of surgical indications and construct an auxiliary diagnosis model. The proposed
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The effect of sarcopenia on erlotinib therapy in patients with metastatic lung adenocarcinoma. Bosn. J. Basic Med. Sci. (IF 3.363) Pub Date : 2022-05-14 Atakan Topcu, Akin Ozturk, Ismail Yurtsever, Mehmet Besiroglu, Ayse Irem Yasin, Haci Mehmet Turk, Mesut Seker
Erlotinib, a tyrosine kinase inhibitor, has been shown to improve the survival of patients with epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer. Sarcopenia is a status with increasing importance in lung cancer, and it may predict a poor prognosis. We aimed to evaluate the impact of sarcopenia on erlotinib therapy and prognosis in patients with EGFR-mutated (exon 19 or 21
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The α7nAChR agonist PNU-282987 ameliorates sepsis-induced acute kidney injury via CD4+CD25+ regulatory T cells in rats. Bosn. J. Basic Med. Sci. (IF 3.363) Pub Date : 2022-05-10 Xiaocui Shi, Juncong Li, Yuzhen Han, Jingyi Wang, Qingping Li, Yue Zheng, Wenxiong Li
The ameliorative effects of α7 nicotinic acetylcholine receptor (α7nAChR) agonists have been demonstrated in acute kidney injury (AKI) caused by multiple stimulations. However, the ameliorative effect of α7nAChR on sepsis-induced acute kidney injury (SAKI) in the cecal ligation and puncture (CLP) model is unclear. Previous studies have demonstrated that α7nAChR is highly expressed on the surface of
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Associations of Non-High-density Lipoprotein Cholesterol and Triglyceride/High-density Lipoprotein Cholesterol Ratio with Coronary Plaque Burden and Plaque Characteristics in Young Adults. Bosn. J. Basic Med. Sci. (IF 3.363) Pub Date : 2022-05-08 Fatih Akin, İbrahim Altun, Burak Ayca, Nuri Kose, İlknur Altun
Coronary artery disease (CAD) is uncommon in young adult patients. However, these patients have different risk factor profiles and high-risk coronary plaques are more common. The aim of this study was to examine the relations between the coronary plaque burden, plaque composition, serum non-high-density lipoprotein cholesterol (non-HDL-C) levels, and triglyceride/high-density lipoprotein cholesterol
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ROS responsive polyethylenimine-based fluorinated polymers for enhanced transfection efficiency and lower cytotoxicity. Bosn. J. Basic Med. Sci. (IF 3.363) Pub Date : 2022-04-30 Peng Hua, Donglin Yang, Ruie Chen, Peiqi Qiu, Meiwan Chen
Cationic polymer polyethylenimine (PEI) plays a crucial role in gene delivery. However, high molecular weight PEI leads to higher efficient transfection efficacy and higher cytotoxicity while low molecular weight PEI exhibits lower transfection performance with lower toxicity. Therefore, effective chemical modification of PEI is required to enhance transfection activity and improve biocompatibility
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Evaluation of cerebrospinal fluid neurofilament light chain levels in multiple sclerosis and non-demyelinating diseases of the central nervous system: clinical and biochemical perspective. Bosn. J. Basic Med. Sci. (IF 3.363) Pub Date : 2022-04-30 Burak Arslan, Gökçe Ayhan Arslan, Aslı Tuncer, Rana Karabudak, Aylin Sepici Dinçel
The neurofilament light chain (NfL) is a promising biomarker in the diagnosis, prognosis, and treatment response evaluation of neurological diseases. The aims of this study were to compare the cerebrospinal fluid (CSF) NfL levels in multiple sclerosis (MS) and certain non-demyelinating diseases of the central nervous system (NDCNS); to determine the relationship between clinical and radiological features
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LKB1 suppression promotes cardiomyocyte regeneration via LKB1-AMPK-YAP axis. Bosn. J. Basic Med. Sci. (IF 3.363) Pub Date : 2022-04-29 Shuang Qu, Qiao Liao, Cheng Yu, Yue Chen, Han Luo, Xuewei Xia, Duofen He, Zaicheng Xu, Pedro A Jose, Zhuxin Li, Wei Eric Wang, Qing Rex Lyu, Chunyu Zeng
The regenerative potential of cardiomyocytes in adult mammals is limited. Previous studies reported that cardiomyocyte proliferation is suppressed by AMP-activated protein kinase (AMPK). The role of liver kinase B1 (LKB1), as the major upstream kinase for AMPK, on cardiomyocyte proliferation is unclear. In this study, we found that the LKB1 levels rapidly increased after birth. With loss- and gain-of-function
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Role and Significance of c-KIT Receptor Tyrosine Kinase in Cancer: A Review. Bosn. J. Basic Med. Sci. (IF 3.363) Pub Date : 2022-04-27 Emana Sheikh, Tony Tran, Semir Vranic, Arkene Levy, R Daniel Bonfil
c-kit is a classical proto-oncogene that encodes a receptor tyrosine kinase (RTK) that responds to stem cell factor (SCF). C-KIT signaling is a critical regulator of cell proliferation, survival, and migration and is implicated in several physiological processes, including pigmentation, hematopoiesis and gut movement. Accumulating evidence suggests that dysregulated c-KIT function, caused by either
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Genetic risk factors in melanoma etiopathogenesis and the role of genetic counseling: A concise review. Bosn. J. Basic Med. Sci. (IF 3.363) Pub Date : 2022-04-21 Nikola Serman, Semir Vranic, Mislav Glibo, Ljiljana Serman, Zrinka Bukvic Mokos
Melanoma is a highly aggressive cancer originating from melanocytes. Its etiopathogenesis is strongly related to genetic, epigenetic, and environmental factors. Melanomas encountered in clinical practice are predominantly sporadic, whereas hereditary melanomas account for approximately 10% of the cases. Hereditary melanomas mainly develop due to mutations in the CDKN2A gene, which encodes two tumor
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First-line treatment of patients with HER2-positive metastatic gastric and gastroesophageal carcinoma. Bosn. J. Basic Med. Sci. (IF 3.363) Pub Date : 2022-04-17 Selin Aktürk Esen, Yakup Ergun, Cihan Erol, Rukiye Arikan, Muhammed Muhiddin Er, Muhammed Mustafa Atci, Atakan Topçu, Gökhan Uçar, Baran Akagündüz, Musa Bariş Aykan, Miraç Özen, Naziyet Köse Baytemur, Melike Özçelik, Elif Şahin, Denizcan Güven, Serkan Menekşe, Naziye Ak, Fatih Teker, Engin Kut, Teoman Şakalar, Özkan Alan, Turgut Kaçan, Nazim Serdar Turhal, Saadettin Kiliçkap, Sema Türker, Mehmet Ali
Fluoropyrimidine+cisplatin/oxaliplatin+trastuzumab therapy is recommended for the first-line treatment of HER2-positive metastatic gastric adenocarcinoma. However, there is no comprehensive study on which platinum-based treatment should be preferred. This study aimed to compare the treatment response and survival characteristics of patients with HER2-positive metastatic gastric or gastroesophageal
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Acceptance, effects, and tolerability in the vaccination process against SARS-CoV-2 among cancer patients in Bosnia and Herzegovina: a single-center cross-sectional study. Bosn. J. Basic Med. Sci. (IF 3.363) Pub Date : 2022-04-08 Timur Ceric, Emir Sokolović, Anes Pašić, Emina Borovac-Gurda, Velda Smajlbegović, Berisa Hasanbegović, Emina Bičakčić Filipović, Elma Kapisazović, Selma Sokolović, Semir Bešlija
The SARS-CoV-2 pandemic has been the main public health issue since the end of 2019. The vaccination campaign in Bosnia and Herzegovina started in April 2021, with several vaccines available. Our study aimed to evaluate the acceptance, effects, and tolerability of vaccines against SARS-COV-2 among cancer patients. We conducted a cross-sectional, observational study between 22 October and 30 November
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Strategies and safety considerations of booster vaccination in COVID-19. Bosn. J. Basic Med. Sci. (IF 3.363) Pub Date : 2022-04-03 Hanyan Meng, Jianhua Mao, Qing Ye
First-generation SARS-CoV-2 vaccines have played a significant role in controlling the COVID-19 pandemic, preventing severe diseases, and reducing mortality. However, the continuous emergence of SARS-CoV-2 variants, the persistence of breakthrough infections, and the seemingly rapid decline in the protective efficacy of SARS-CoV-2 vaccines have presented additional challenges for the next phase. There
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Exploring autophagy related prognostic genes of Alzheimer's disease based on pathway crosstalk analysis. Bosn. J. Basic Med. Sci. (IF 3.363) Pub Date : 2022-04-02 Fang Qian, Wei Kong, Shuaiqun Wang
Recent studies have shown that different signaling pathways are involved in the pathogenesis of Alzheimer's disease (AD), with complex molecular connections existing between these pathways. Autophagy is crucial for the degradation and production of pathogenic proteins in AD, and it shows link with other AD-related pathways. However, current methods for identifying potential therapeutic targets for
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Astrocytes and human artificial blood-brain barrier models. Bosn. J. Basic Med. Sci. (IF 3.363) Pub Date : 2022-04-01 Tanja Zidarič, Lidija Gradišnik, Tomaž Velnar
The blood-brain barrier (BBB) functions as a highly selective border of endothelial cells, protecting the central nervous system from potentially harmful substances by selectively controlling the entry of cells and molecules, including components of the immune system. To study the BBB properties, find suitable therapies, and identify new drug targets, there is a need to develop representative in vitro
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Prognostic nomograms for predicting overall survival and cancer-specific survival of patients with very early onset colorectal cancer: a population‑based analysis. Bosn. J. Basic Med. Sci. (IF 3.363) Pub Date : 2022-03-27 Bingtian Dong, Yuping Chen, Guorong Lyu
In contrast to the declining incidence in older populations, the incidence of very early onset colorectal cancer (VEO-CRC) patients (aged ≤40 years) has been increasing in different regions of the world. In this study, we aimed to establish nomogram models for the prognostic prediction of patients with VEO-CRC for both overall survival (OS) and cancer-specific survival (CSS). Patients diagnosed with
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Regulatory aspects of biological medicines in Bosnia and Herzegovina. Bosn. J. Basic Med. Sci. (IF 3.363) Pub Date : 2022-03-23 Biljana Tubić, Saša Jungić
The use of the biological medicines, also called "biologics," has contributed to the progress of the treatment of many chronic diseases, such as cancer, rheumatoid arthritis, Crohn's disease, multiple sclerosis, and psoriasis. However, biologicals are expensive for healthcare systems in several countries. Their availability has been a global issue, which has affected many patients that suffer from
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The Oncology Association of Bosnia and Herzegovina's Recommendations for Fertility Preservation in Oncologic Patients. Bosn. J. Basic Med. Sci. (IF 3.363) Pub Date : 2022-03-15 Timur Cerić, Emir Sokolović, Berisa Hasanbegović, Anes Pašić, Zdenka Gojković, Jelena Vladičić Mašić, Nikolina Dukić, Inga Marijanović, Alma Mekić Abazović, Ibrahim Šišić, Dijana Koprić, Mustafa Hammami, Semir Bešlija
Malignancy is one of the major public health problems in Bosnia and Herzegovina. Along with breakthroughs in specific oncological therapy, improving the quality of life of cancer patients and management of therapy-induced side effects need to be recognized as a priority in the comprehensive cancer patient care. Fertility loss after cancer treatment is a field requiring special attention due to its
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Small cell variant of chromophobe renal cell carcinoma: Clinicopathologic, and molecular-genetic analysis of 10 cases. Bosn. J. Basic Med. Sci. (IF 3.363) Pub Date : 2022-03-10 Joanna Rogala, Fumiyoshi Kojima, Reza Alaghehbandan, Nikola Ptakova, Ana Bravc, Stela Bulimbasic, Delia Perez Montiel, Maryna Slisarenko, Leila Ali, Levente Kuthi, Kristyna Pivovarcikova, Kvetoslava Michalova, Boris Bartovic, Adriena Bartos Vesela, Olga Dolejsova, Michal Michal, Ondrej Hes
The morphologic diversity of chromophobe renal cell carcinoma (ChRCC) is well-known. Aside from typical morphology, pigmented adenomatoid, multicystic and papillary patterns have been described. Ten cases of CHRCC composed of small cell population in various percentages were analysed, using morphologic parameters, immunohistochemistry and next-generation sequencing (NGS) testing. Patients were five
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Identification and Verification of the Ferroptosis- and Pyroptosis-Associated Prognostic Signature for low-grade Glioma. Bosn. J. Basic Med. Sci. (IF 3.363) Pub Date : 2022-03-09 Jie Wang, Jie Ren, Jifeng Liu, Linyun Zhang, Qihang Yuan, Bin Dong
Accumulating evidence reveals that ferroptosis and pyroptosis play pivotal roles in tumorigenesis of low-grade glioma (LGG). In this research, we aimed to classify molecular subtypes and further identify and verify a novel multigene signature in LGG on the basis of ferroptosis and pyroptosis-related genes (FPRGs). Raw sequencing data and corresponding clinical data of LGG samples retrieved from the
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Thiersch graft follow-up with narrow band imaging for Acquired atresia of the external auditory canal: Canaloplasty with thiersch graft vs vascularization evaluated with narrow band imaging. Bosn. J. Basic Med. Sci. (IF 3.363) Pub Date : 2022-03-02 Annalisa Pace, Valeria Rossetti, Irene Claudia Visconti, Alessandro Milani, Giannicola Iannella, Antonino Maniaci, Salvatore Cocuzza, Giuseppe Magliulo
Acquired atresia of the external ear canal is a narrowing of the external ear canal (EAC) that appears obstructed by fibrous tissue or bone tissue. Acquired atresia has two different phases: wet and dry stage. Computed tomography (CT) scan may show a scan where soft tissue fills EAC. Treatment may be medical and/or surgical. The surgical treatment of choice is represented by canaloplasty with a skin-free
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Association between fasting blood glucose and thyroid stimulating hormones and suicidal tendency and disease severity in patients with major depressive disorder. Bosn. J. Basic Med. Sci. (IF 3.363) Pub Date : 2022-02-28 Weiting Liu, Zezhen Wu, Min Sun, Shuo Zhang, Juan Yuan, Dan Zhu, Guimimg Yan, Kaijian Hou
Thyroid dysfunction and diabetes are reported to be associated with depression. However, their role in the suicide risk in patients with major depressive disorder (MDD) is unclear. The purpose of this study was to investigate and compare thyroid dysfunction and diabetes between suicide attempters and non-suicide attempters in a large sample of first-episode drug-naïve (FEND) MDD patients. A descriptive
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The impact of vitamin and mineral supplements usage prior to COVID-19 infection on disease severity and hospitalization. Bosn. J. Basic Med. Sci. (IF 3.363) Pub Date : 2022-02-28 Refat Nimer, Omar Khabour, Samer Swedan, Hassan Kofahi
The COVID-19 pandemic has caused a global public health emergency. Nutritional status is suggested to be related to the severity of COVID-19 infection. Herein, we aimed to explore the impact of using vitamin and mineral supplements prior to COVID-19 infection on disease severity and hospitalization. In addition, the prior use of aspirin as an anticoagulant on the disease severity was investigated.
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Circular RNA circ_0020014 contributes to osteoarthritis progression via miR-613/ADAMTS5 axis. Bosn. J. Basic Med. Sci. (IF 3.363) Pub Date : 2022-02-28 Zirui Yu, Fei Cong, Wentao Zhang, Tao Song, Shihui Zhang, Renqi Jiang
Circular RNAs (circRNAs) have been shown to be significant regulators in osteoarthritis (OA), whereas the functional effect of circ_0020014 in OA remains unclear. Our goal was to try and understand the underlying regulatory mechanism of circ_0020014 in OA. The cartilage tissue was obtained from OA patients and trauma patients. Interleukin-1β (IL-1β)-treated chondrocytes (CHON-001) were used as the
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Impact of metabolic syndrome on the risk of endometrial cancer and the role of lifestyle in prevention. Bosn. J. Basic Med. Sci. (IF 3.363) Pub Date : 2022-02-27 Alejandra Rocío Pérez-Martín, Denisse Castro-Eguiluz, Lucely Cetina-Pérez, Yadira Velasco-Torres, Antonio Bahena-González, Edgar Montes-Servín, Ernesto González-Ibarra, Raquel Espinoza-Romero, Dolores Gallardo-Rincón
Endometrial cancer is the second gynecological cancer with the highest global incidence. Among many associated risk factors, Among the risk factors, metabolic syndrome is an important and preventable one. It comprises a group of conditions that often occur together: central adiposity, hyperglycemia, arterial hypertension, and atherogenic dyslipidemia. This review aimed to describe the epidemiological
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Global DNA methylation and chondrogenesis of rat limb buds in a three-dimensional organ culture system. Bosn. J. Basic Med. Sci. (IF 3.363) Pub Date : 2022-02-21 Vedrana Mužić Radović, Paula Bunoza, Tihana Marić, Marta Himelreich-Perić, Floriana Bulić-Jakuš, Marta Takahashi, Gordana Jurić-Lekić, Nino Sinčić, Davor Ježek, Ana Katušić-Bojanac
Although DNA methylation epigenetically regulates development, data on global DNA methylation during development of limb buds (LBs) are scarce. We aimed to investigate the global DNA methylation developmental dynamics in rat LBs cultivated in a serum-supplemented (SS) and in chemically defined serum- and protein-free (SF) three-dimensional organ culture. Fischer rat front- and hind-LBs at 13th and
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Untangling the relationship between hemoglobin, peak troponin level, and mortality in patients with myocardial infarction. Bosn. J. Basic Med. Sci. (IF 3.363) Pub Date : 2022-02-18 Vojko Kanic, Gregor Kompara, David Suran, Nina Glavnik Poznic
Patients with a history of myocardial infarction (MI) and lower admission hemoglobin (aHb) levels have a worse outcome than patients with higher aHb, but lower or similar peaks in enzymatic infarct size. Hemoglobin levels are positively correlated with body surface area (BSA), which is positively correlated with cardiac mass. We hypothesized that patients with lower aHb suffer comparatively greater
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Dysregulated circulating miR-4429 serves as a novel non-invasive biomarker and is correlated with EGFR mutation in patients with non-small cell lung cancer. Bosn. J. Basic Med. Sci. (IF 3.363) Pub Date : 2022-02-15 Mei Ruan, Liyan Sun, Wen Qiu, Yanjie Dong, Chunmei Fang, Haiyan Cui, Jiansheng Rong
This study aimed to investigate the correlation between microRNA (miR)-4429 and epidermal growth factor receptor (EGFR), the expression and clinical significance of miR-4429 in patients with non-small cell lung cancer (NSCLC), and the relationship between miR-4429 and EGFR mutation in NSCLC patients. Blood samples were collected from 122 NSCLC patients and 72 healthy volunteers. miR-4429 expression
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Osteoarthritis of the knee - biochemical aspect of applied therapies (review). Bosn. J. Basic Med. Sci. (IF 3.363) Pub Date : 2022-02-13 Anna Horecka, Anna Hordyjewska, Tomasz Blicharski, Jacek Kurzepa
The most prevalent form of arthritis is osteoarthritis (OA) of the knee, which is characterized by a degeneration of articular cartilage resulting in the development of osteophytes, or bone spurs. Main goals of OA treatment are to reduce pain, slow the disease progression, and improve joint function and the quality of life. The purpose of this study was to verify all the therapies recommended by the
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miR-212-3p attenuates neuroinflammation of rats with Alzheimer's disease via regulating the SP1/BACE1/NLRP3/Caspase-1 signaling pathway. Bosn. J. Basic Med. Sci. (IF 3.363) Pub Date : 2022-02-12 Wei Nong,Chuanhong Bao,Yixin Chen,Zhiquan Wei
Alzheimer's disease (AD) ranks as the leading cause of dementia. MicroRNA (miR)-212-3p has been identified to exert neuroprotective effects on brain disorders. The current study analyzed the protective role of miR-212-3p in AD rats via regulating the nucleotide-binding oligomerization domain-like receptor family pyrin domain containing 3 (NLRP3)/Caspase-1 signaling pathway. The AD rat model was established
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Intravenous immunoglobulin: A potential treatment for the post-acute sequelae of SARS-Cov-2 infection? Bosn. J. Basic Med. Sci. (IF 3.363) Pub Date : 2022-02-12 Sandra Reznik,Amit Tiwari,Charles Ashby
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Comparison of the vitality tests used in the dental clinical practice and histological analysis of the dental pulp. Bosn. J. Basic Med. Sci. (IF 3.363) Pub Date : 2022-06-01 Ana Tenyi,Lidija Nemeth,Aljaž Golež,Ksenija Cankar,Aleksandra Milutinović
In dentistry, indirect diagnostic methods such as electrical sensibility testing and pulse oximetry are used to assess the status of the pulp. Our study aimed to determine the correlation between hemoglobin oxygen saturation and vascular volume density (Vvasc). We also wanted to examine an electrical sensibility test and the volume density of myelinated nerve fibers (Vnerv). Twenty-six intact permanent
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Obstructive sleep apnoea patients vs laryngopharyngeal reflux disease: Non-invasive evaluation with NBI and pepsin detection in tears. Bosn. J. Basic Med. Sci. (IF 3.363) Pub Date : 2022-02-10 Annalisa Pace,Valeria Rossetti,Alessandro Milani,Giannicola Iannella,Salvatore Cocuzza,Antonino Maniaci,Danilo Alunni Fegatelli,Annarita Vestri,Antonio Greco,Marco De Vincentiis,Francesca Giovannetti,Rocco Plateroti,Giuseppe Magliulo
Obstructive sleep apnoea (OSA) and laryngopharyngeal reflux disease (LPR) are two common diseases that lower patients' quality of life. OSA is defined by cyclic events of airflow obstruction that occur during sleep, while LPR is characterized by upper airway inflammatory signs and symptoms due to the return of gastroduodenal gaseous and liquid elements. pH-metry is the gold standard in LPR diagnosis
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Tenofovir-silver nanoparticles conjugate ameliorates neurocognitive disorders and protects ultrastructural and cytoarchitectonic properties of the prefrontal cortex in diabetic rats. Bosn. J. Basic Med. Sci. (IF 3.363) Pub Date : 2022-02-05 Sodiq Lawal, Samuel Oluwaseun Olojede, Sheu Oluwadare Sulaiman, Okikioluwa Stephen Aladeyelu, Roshila Moodley, Edwin C Stephen Naidu, Carmen Olivia Rennie, Onyemaechi Okpara Azu
Tenofovir disoproxil fumarate (TDF) is the highly recommended antiretroviral drug in human immunodeficiency virus management. Although research has shown the neurological and metabolic disorders associated with TDF administration, the effect of TDF-silver nanoparticles conjugate (TDF-AgNPs) on the disorders has not been fully elucidated. Thus, this study evaluated the neuroprotective effects of TDF-AgNPs
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The Expression of VISTA on CD4+ T Cells Associate with Poor Prognosis and Immune Status in Non-small Cell Lung Cancer Patients. Bosn. J. Basic Med. Sci. (IF 3.363) Pub Date : 2022-02-05 Shengyao Ma, Liya Qin, Xinling Wang, Weiyu Wang, Jinfeng Li, Huaijie Wang, Hanyue Li, Xiaoshan Cai, Yang Yang, Meihua Qu
Besides the two main histologic types of papillary thyroid carcinoma (PTC), the classical PTC (CL-PTC) and the follicular variant PTC (FV-PTC), several other variants are described. The encapsulated FV-PTC variant was recently reclassified as noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) due to its similarities to benign lesions. Specific molecular signatures
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Dynamic Microglial Activation is Associated with LPS-induced Depressive-like Behavior in Mice: An [18F] DPA-714 PET Imaging Study. Bosn. J. Basic Med. Sci. (IF 3.363) Pub Date : 2022-01-30 Tian Qiu, Jiamei Guo, Lixia Wang, Lei Shi, Ming Ai, Xia Zhu, Zhiping Peng, Li Kuang
Major depressive disorder (MDD) is a highly pervasive, severe psychological condition for which the precise underlying pathophysiology is incompletely understood, although microglial activation is known to play a role in this context. In this study we analyzed the association between neuroinflammation and depressive-like behaviors in a lipopolysaccharide (LPS)-induced mouse model system using 10-12-week-old
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The Association between NOTCH3 expression and the clinical outcome in the urothelial bladder cancer patients. Bosn. J. Basic Med. Sci. (IF 3.363) Pub Date : 2022-01-24 Ana Ristic Petrovic, Dragana Stokanović, Slavica Stojnev, Milena Potić Floranović, Miljan Krstić, Ivana Djordjević, Aleksandar Skakić, Ljubinka Janković Veličković
Disrupted NOTCH activity is a driving event in urothelial bladder cancer (UBC). After activation by hypoxia, the NOTCH3 receptor participates in tumor cell proliferation, acquisition of the epithelial-mesenchymal transition phenotype, and angiogenesis. The aim was to analyze the association of NOTCH3 expression with histopathological and clinical parameters, and to determine its predictive impact on
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Whole-exome sequencing reveals rare genetic variations in ovarian granulosa cell tumor. Bosn. J. Basic Med. Sci. (IF 3.363) Pub Date : 2022-01-17 Seungyeon Kim, Songmi Kim, Seyoung Mun, Yongsik Kwak, Kwang-Sun Suh, Song-Yi Choi, Kyudong Han
Ovarian granulosa cell tumor (OGCT) is a rare ovarian tumor that accounts for about 2-5% of all ovarian tumors. Despite the low grade of ovarian tumors, high and late recurrences are common in OGCT patients. Even though this tumor usually occurs in adult women with high estrogen levels, the cause of OGCT is still unknown. To screen genetic variants associated with OGCT, we collected normal and matched-tumor
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The hemoglobin, albumin, lymphocyte, and platelet (HALP) score as a prognostic marker for patients with upper tract urothelial carcinoma undergoing radical nephroureterectomy: a retrospective study from two centers. Bosn. J. Basic Med. Sci. (IF 3.363) Pub Date : 2022-01-12 Xiaomin Gao, Binwei Lin, Qi Lin, Tingyu Ye, Tao Zhou, Maolin Hu, Honghui Zhu, Feng Lu, Wei Chen, Peng Xia, Fangyi Zhang, Zhixian Yu
The combination of hemoglobin, albumin, lymphocyte, and platelet (HALP) score has been confirmed as an important risk biomarker in several cancers. Hence, we aimed at evaluating the prognostic value of the HALP score in patients with non-metastatic upper tract urothelial carcinoma (UTUC). We retrospectively enrolled 533 of the 640 patients from two centers (315 and 325 patients, respectively) who underwent
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TPRG1 contributes to inflammation and cell proliferation of cystitis glandularis through regulating NF-кB/COX2/PGE2 axis. Bosn. J. Basic Med. Sci. (IF 3.363) Pub Date : 2022-01-07 Tao Hong, Songzhe Piao, Liangxue Sun, Yiran Tao, Mang Ke
Cystitis glandularis is characterized by chronic inflammation and hyperproliferation of bladder mucosa, and contributes to progression of bladder adenocarcinoma. TPRG1 (Tumor Protein P63 Regulated 1) is related to cellular inflammatory response, and dysregulation of TPRG1 in tumor tissues is associated with tumor early recurrence. The effect of TPRG1 on cystitis glandularis was investigated in this
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Impact of Smoking on the Incidence and Postoperative Complications of Total Knee Arthroplasty: A Systematic Review and Meta-Analysis of Cohort Studies. Bosn. J. Basic Med. Sci. (IF 3.363) Pub Date : 2021-12-19 Yuqi He, Mohamed Omar, Xiaoyuan Feng, Claudia Neunaber, Michael Jagodzinski
Osteoarthritis and rheumatoid arthritis are the most ubiquitous joint disorders which cause tremendous loss of life quality and impose an economic burden on society. At present, the treatment options for these two diseases comprise non-operative and surgical treatments, amongst those total knee arthroplasties (TKA). Various studies have recognized smoking as a significant risk factor for postoperative
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MicroRNA-573 inhibits cell proliferation, migration and invasion and is downregulated by PICSAR in cutaneous squamous cell carcinoma. Bosn. J. Basic Med. Sci. (IF 3.363) Pub Date : 2021-12-15 Yanhua Wang, Shengjian Tang, Jianping Lv
The incidence of cutaneous squamous cell carcinoma (cSCC) has been increasing in recent years. Meanwhile, microRNAs (miRNAs) have been found to play vital roles in various cancers, including cSCC. This study aimed to investigate the expression of microRNA-573 (miR-573) in cSCC, its relationship with long non-coding RNA PICSAR and analyze its biological role. The relationship between PICSAR and miR-573
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LncRNA ADAMTS9-AS1 knockdown suppresses cell proliferation and migration in glioma via down-regulating Wnt/β-catenin signaling pathway. Bosn. J. Basic Med. Sci. (IF 3.363) Pub Date : 2021-12-11 Chunhui Zhou, Hulin Zhao, Shuiwei Wang, Chao Dong, Fan Yang, Jianning Zhang
The long non-coding RNA antisense 1 ADAMTS9-AS1 has been reported to serve as an oncogene or tumor suppressor in several tumors, including colorectal cancer and hepatocellular carcinoma. Nevertheless, the clinical significance and biological behaviors of ADAMTS9-AS1 in glioma still remain unclear. Therefore, the goal of this study was to evaluate the functional roles and potential mechanisms of ADAMTS9-AS1
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Three-dimensional telomere profiles in papillary thyroid cancer variants: a pilot study. Bosn. J. Basic Med. Sci. (IF 3.363) Pub Date : 2021-12-08 Aline Rangel-Pozzo, Tinuccia Dettori, Daniela Virginia Frau, Federica Etzi, John Gartner, Garbor Fisher, Roberta Vanni, Sabine Mai, Paola Caria
Besides the two main histologic types of papillary thyroid carcinoma (PTC), the classical PTC (CL-PTC) and the follicular variant PTC (FV-PTC), several other variants are described. The encapsulated FV-PTC variant was recently reclassified as noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) due to its similarities to benign lesions. Specific molecular signatures
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Protocatechuic acid as an inhibitor of the JNK/CXCL1/CXCR2 pathway relieves neuropathic pain in CCI rats. Bosn. J. Basic Med. Sci. (IF 3.363) Pub Date : 2021-11-23 Hong-Xia Chang, Yue-Feng Zhao
Emerging evidence has shown that protocatechuic acid (PCA) has antioxidant and anti-inflammatory effects. It can alleviate the injury of sciatic nerve, while the mechanism of its therapeutic effect on neuralgia remains unknown . In vivo, chromium bowel ligation was used to establish a chronic constriction injury (CCI) rat model to induce sciatic nerve pain, then two doses of PCA were used to treat
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Clinical features and major bleeding predictors for 161 fatal cases of COVID-19: A retrospective observational study. Bosn. J. Basic Med. Sci. (IF 3.363) Pub Date : 2021-11-22 Gokhan Alici, Hasan Ali Barman, Ramazan Asoglu, Adem Atici, Atike Nazli Akciger, Omer Sit, Omer Dogan, Yucel Yavuz, Songul Borahan, Omer Genc, Baris Gungor
The aim of this study was to investigate the patient characteristics and laboratory parameters for COVID-19 non-survivors as well as to find risk factors for major bleeding complications. For this retrospective study, the data of patients who died with COVID-19 in our intensive care unit were collected in the period of March 20 - April 30, 2020. D-dimer, platelet count, C-reactive protein (CRP), troponin
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Comparison of confirmed and probable COVID-19 patients in the intensive care unit during the normalization period. Bosn. J. Basic Med. Sci. (IF 3.363) Pub Date : 2021-11-22 Fatma İrem Yeşiler, Mesher Çapras, Emre Kandemir, Helin Şahintürk, Ender Gedik, Pınar Zeyneloğlu
The decrease in social distance together with the normalization period as of June 1, 2020 in our country caused an increase in the number of COVID 19 patients. Our aim was to compare the demographic features, clinical courses and outcomes of confirmed and probable coronavirus disease 2019 (COVID-19) patients admitted to our intensive care unit (ICU) during the normalization period. Critically ill 128
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Construction of a novel ferroptosis-related gene signature for predicting prognosis and immune microenvironment in acute myeloid leukemia. Bosn. J. Basic Med. Sci. (IF 3.363) Pub Date : 2021-11-16 Xianbo Huang, De Zhou, Xiujin Ye, Jie Jin
Acute myeloid leukemia (AML) is a highly heterogeneous hematopoietic malignancy that strongly correlates with poor clinical outcomes. Ferroptosis is an iron-dependent, non-apoptotic form of regulated cell death which plays an important role in various human cancers. Nevertheless, the prognostic significance and functions of ferroptosis-related genes (FRGs) in AML have not received sufficient attention
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New insights into the pathological development of dyslipidemia in patients with hypothyroidism. Bosn. J. Basic Med. Sci. (IF 3.363) Pub Date : 2021-11-15 Xin Su, Xiang Chen, Hua Peng, Jingjin Song, Bin Wang, Xijie Wu
According to the previous reports, hypothyroidism has been shown to be strongly correlated with increased circulating concentrations of total cholesterol, low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG). Notably, thyroid hormones are confirmed to modulate the production, clearance, and transformation process of cholesterol within circulation of mammals. Moreover, emerging evidence
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Emerging roles of sortilin in affecting the metabolism of glucose and lipid profiles. Bosn. J. Basic Med. Sci. (IF 3.363) Pub Date : 2021-11-15 Xin Su, Linjian Chen, Xiang Chen, Cuilian Dai, Bin Wang
Dyslipidemia has recently been identified as an important factor in modulating the progression of several health conditions, grouped as cardio-metabolic syndrome and including obesity,insulin resistance, and atherosclerosis. Among multiple factors which regulate the development of cardio-metabolic syndrome, sortilin has been found in multiple cell types, such as adipocyte, hepatocyte, and macrophage
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MKL1 is a key biomarker correlated with immune infiltrates and chemosensitivity in breast cancer. Bosn. J. Basic Med. Sci. (IF 3.363) Pub Date : 2021-11-10 Yijia Hua, Mengzhu Yang
Megakaryocytic leukemia 1 (MKL1) acts as a transcription factor in the regulation of the immune system and is associated with cancer biology. However, its function in the infiltrating immune cells in breast cancer has not been explored. Our study aimed to analyze the expression of MKL1 in The Cancer Genome Atlas (TCGA) breast cancer dataset. The aim of this study was to evaluate the correlations between
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Attributes of intestinal microbiota composition and their correlation with clinical primary nonresponse to anti-TNF-α agents in inflammatory bowel disease patients. Bosn. J. Basic Med. Sci. (IF 3.363) Pub Date : 2021-11-10 Hanan Alatawi, Mahmoud Mosli, Omar I Saadah, Vito Annese, Rashad Al-Hindi, Marfat Alatawy, Hadba Al-Amrah, Dikhnah Alshehri, Ahmad Bahieldin, Sherif Edris
The largest microbial aggregation in the human body exists in the gastrointestinal tract. The microbiota in the host gastrointestinal tract comprises a diverse ecosystem, and the intestinal microbiota plays a vital role in maintaining gut homeostasis. This study aims to examine whether the gut microbiota influences unresponsiveness to anti-TNF-α treatments in primary nonresponder patients, and consequently