
显示样式: 排序: IF: - GO 导出
-
Assessment of Wnt pathway selected gene expression levels in peripheral blood mononuclear cells (PBMCs) of postmenopausal patients with low bone mass. Bosn. J. Basic Med. Sci. (IF 2.05) Pub Date : 2020-12-21 Michal Stuss; Monika Migdalska-Sęk; Ewa Brzezianska-Lasota; Marta Michalska-Kasiczak; Pawel Bazela; Ewa Sewerynek
The purpose of the study was to assess the expression of selected genes of the Wnt pathway: APC, AXIN1, CTNNB1, DKK1, GSK3β, KREMEN1, SFRP1, WNT1 in peripheral blood mononuclear cells (PBMC) of patients, selected in consideration of their BMD (bone mineral density) and the occurrence of low-energy fractures. The study involved 45 postmenopausal women, divided into 4 groups, according to BMD and fracture
-
Trends of incidence and prognosis of upper tract urothelial carcinoma. Bosn. J. Basic Med. Sci. (IF 2.05) Pub Date : 2020-12-18 Jianping Wu; Shuqiu Chen; Xiaoli Wu; Weipu Mao; Yali Wang; Bin Xu; Donghui Zheng; Ming Chen
The purpose of this study was to investigate trends in the incidence of upper tract urothelial carcinoma (UTUC) in patients and to establish a reliable and practical nomogram based on significant clinical factors to predict the overall survival (OS) and cancer-specific survival (CSS) of UTUC patients. The Surveillance, Epidemiology, and End Results (SEER) database was used to extract data on UTUC patients
-
Computed tomography in the diagnosis of intraperitoneal effusions: The role of texture analysis. Bosn. J. Basic Med. Sci. (IF 2.05) Pub Date : 2020-12-17 Csaba Csutak; Paul-Andrei Ștefan; Roxana-Adelina Lupean; Lavinia Manuela Lenghel; Carmen Mihaela Mihu; Andrei Lebovici
The morphological changes advocating for peritoneal carcinomatosis are inconsistent and may be visible only in later stages of the disease. However, malignant ascites represents an early sign, and this fluid exhibits specific histological characteristics. This study aimed to quantify the fluid properties on computed tomography (CT) images of intraperitoneal effusions through texture analysis and evaluate
-
MPTP-induced mouse model of Parkinson's disease: A promising direction of therapeutic strategies. Bosn. J. Basic Med. Sci. (IF 2.05) Pub Date : 2020-12-14 Che Norma Mat Taib; Musa Mustapha
Amongst the popular animal models of Parkinson's disease (PD) commonly used in researches are those that employ neurotoxins, especially the 1-methyl- 4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP). MPTP neurotoxin exerts its neurotoxicity by causing a barrage of insults such as oxidative stress, mitochondrial apoptosis, inflammation, excitotoxicity, and formation of inclusion bodies acting singly and
-
Prevalence, clinical features and prognosis of malignant solid tumors in infants: a 14-year study. Bosn. J. Basic Med. Sci. (IF 2.05) Pub Date : 2020-12-01 Tian Zhi; Wei-Ling Zhang; Yi Zhang; Yi-Zhuo Wang; Dong-Sheng Huang
The onset of malignant solid tumors in infants is insidious and difficult to diagnose on time. The purpose of our study is to provide a theoretical basis for clinical diagnosis by retrospective analysis of the data in the past 14 years. Here, we retrospectively collected the clinical data of infants aged 0-12 months with malignant solid tumors in Beijing Tongren Hospital Affiliated to Capital Medical
-
The association between serine hydroxymethyl transferase 1 gene hypermethylation and ischemic stroke. Bosn. J. Basic Med. Sci. (IF 2.05) Pub Date : 2020-11-30 Junnan Wang; Junqing Gu; Yi Huang; Yuanjian Fang; Jinhui Lin
This study aimed to determine the correlation between serine hydroxymethyl transferase 1 (SHMT1) gene methylation and ischemic stroke. A total of 202 age- and sex-matched individuals were included. Quantitative methylation-specific polymerase chain reaction (qMSP-PCR) was used to analyze the DNA methylation level. The plasma homocysteine (Hcy) concentration was much higher in ischemic cases than in
-
Accelerated atherosclerosis in premenopausal women with rheumatoid arthritis - 15-year follow-up. Bosn. J. Basic Med. Sci. (IF 2.05) Pub Date : 2020-11-25 Metka Koren Krajnc; Radovan Hojs; Iztok Holc; Željko Knez; Artur Pahor
Rheumatoid arthritis (RA) is a chronic inflammatory disease associated with increased mortality and morbidity due to the higher cardiovascular risk in these patients. Traditional risk factors are not the only answer for the accelerated atherosclerosis. In a long-term prospective study, we investigated the relationship between asymptomatic atherosclerosis and traditional risk factors and inflammatory
-
Raloxifene inhibits the overexpression of TGF-β1 in cartilage and regulates the metabolism of subchondral bone in rats with osteoporotic osteoarthritis. Bosn. J. Basic Med. Sci. (IF 2.05) Pub Date : 2020-11-19 Shao-Hua Ping; Fa-Ming Tian; Hao Liu; Qi Sun; Li-Tao Shao; Qiang-Qiang Lian; Liu Zhang
Overexpression of transforming growth factor-beta 1 (TGF-β1) and subchondral bone remodeling play key roles in osteoarthritis (OA). Raloxifene (RAL) reduces the serum level of TGF-β1 in postmenopausal women. However, the effect of RAL on TGF-β1 expression in articular cartilage remains unclear. Therefore, we aimed to investigate the protective effect of RAL against osteoporotic OA mediated by TGF-β1
-
Stomach-specific c-Myc overexpression drives gastric adenoma in mice via AKT/mTOR signaling. Bosn. J. Basic Med. Sci. (IF 2.05) Pub Date : 2020-11-19 Jing Liu; Wenxin Feng; Min Liu; Hanyu Rao; Xiaoxue Li; Yan Teng; Xiao Yang; Jin Xu; Weiqiang Gao; Li Li
Gastric cancer (GC) is one of the most common malignant cancers in the world. c-Myc, a well-known oncogene, is commonly amplified in many cancers, including gastric cancer. However, it is still not completely understood how c-Myc functions in GC. Here, we generated a stomach-specific c-Myc transgenic mouse model to investigate its role in GC. We found that overexpression of c-Myc in Atp4b+ gastric
-
A plea for extension of the anatomical nomenclature: Vessels. Bosn. J. Basic Med. Sci. (IF 2.05) Pub Date : 2020-11-17 David Kachlik; Vladimir Musil; Alzbeta Blankova; Zuzana Marvanova; Jakub Miletin; Daniela Trachtova; Vlasta Dvorakova; Vaclav Baca
This article is the fourth and last part of a series aimed at extending and correcting the anatomical nomenclature. Because of the rapid development of internet and the use of electronic formats in communication in anatomy, embryology, histology, medical education and clinical medicine, an appropriate, precise and concise anatomical nomenclature is required. Such tool enables to avoid any potential
-
Bionformatics analysis reveals TSPAN1 as a candidate biomarker of progression and prognosis in pancreatic cancer. Bosn. J. Basic Med. Sci. (IF 2.05) Pub Date : 2020-11-14 Chenhui Ma; ZeLong Cui; YiChao Wang; Lei Zhang; JunYe Wen; HuaiBin Guo; Na Li; WanXing Zhang
Pancreatic cancer (PCC) is a common malignant tumor of the digestive system that is resistant to traditional treatments and has an overall 5-year survival rate of less than 7%. Transcriptomics research provides reliable biomarkers for diagnosis, prognosis and clinical precision treatment, as well as the identification of molecular targets for the development of drugs to improve patient survival. We
-
Epigenetically inactivated RASSF1A as a tumor biomarker. Bosn. J. Basic Med. Sci. (IF 2.05) Pub Date : 2020-11-11 Dora Raos; Monika Ulamec; Ana Katusic Bojanac; Floriana Bulic-Jakus; Davor Jezek; Nino Sincic
RASSF1A represents one of the eight isoforms of the RASSF1 gene. RASSF1A is a tumor suppressor gene whose inactivation influences tumor initiation and development. In cancer, RASSF1A is frequently inactivated by mutations, loss of heterozygosity and, most commonly, by promoter hypermethylation. As epigenetic inactivation of RASSF1A was detected in various cancer types, it was extensively investigated
-
Can NLR, PLR and LMR be used as prognostic indicators in patients with pulmonary embolism? A commentary. Bosn. J. Basic Med. Sci. (IF 2.05) Pub Date : 2020-11-06 Cihan Bedel; Mustafa Korkut; Hamit Hakan Armağan
This letter comments the article DOI: https://doi.org/10.17305/bjbms.2019.4445.
-
Can NLR, PLR and LMR be used as prognostic indicators in patients with pulmonary embolism? Author's reply on commentary. Bosn. J. Basic Med. Sci. (IF 2.05) Pub Date : 2020-11-06 Nuri Kose; Tarık Yıldırım; Fatih Akın; Seda Elçim Yıldırım; Ibrahim Altun
This letter is answer to the commentary DOI: 10.17305/bjbms.2020.5236.
-
Rapid, multimodal, critical care knowledge-sharing platform for COVID-19 pandemics. Bosn. J. Basic Med. Sci. (IF 2.05) Pub Date : 2020-10-29 Amra Sakusic; Dragana Markotic; Yue Dong; Emir Festic; Vladimir Krajinovic; Alan Sustic; Natasa Milivojevic; Milka Jandric; Srdjan Gavrilovic; Alexander Niven; Pedja Kovacevic; Ognjen Gajic
In many areas of the world, critical care providers caring for COVID-19 patients lacked specific knowledge and were exposed to the abundance of new and unfiltered information. With support from the World Health Organization, we created a multimodal tele-education intervention to rapidly share critical care knowledge related to COVID-19 targeting providers in a region of Southeastern Europe. We delivered
-
Tranexamic acid is associated with decreased transfusion, hospital length of stay, and hospital cost in simultaneous bilateral total knee arthroplasty. Bosn. J. Basic Med. Sci. (IF 2.05) Pub Date : 2020-10-27 Ryan D'Souza; Christopher Duncan; Daniel Whiting; Michael Brown; Matthew Warner; Hugh Smith; Hilal Kremers; Thomas Stewart
Tranexamic acid (TXA) reduces blood loss and transfusion rates in unilateral total knee arthroplasty (TKA), but there is limited data regarding its efficacy in bilateral TKA. This study reports the impact TXA has on clinical outcomes and hospital cost of care in simultaneous, primary bilateral TKA. The 449 patients were retrospectively reviewed. Primary outcomes included the rates of allogeneic and
-
Kawasaki-like disease and acute myocarditis in the SARS-CoV-2 pandemic - reports of three adolescents. Bosn. J. Basic Med. Sci. (IF 2.05) Pub Date : 2020-10-16 Stasa Krasic; Sergej Prijic; Predrag Minic; Gordana Petrovic; Dejan Nesic; Aleksandra Paripovic; Milena Vasiljevic; Borko Gobeljic; Vladislav Vukomanovic
The novel coronavirus disease (COVID-19) may induce multisystem inflammatory syndrome in children, which may be associated with Kawasaki-like disease, and cardiac injury. In this study, we presented three male adolescents with multisystem inflammatory syndrome and myocardial injury admitted to the hospital during the peak of COVID-19 pandemic. All of the three patients had a history of fever, gastrointestinal
-
SARS-CoV-2 virus outbreak and the emergency public health measures in Bosnia and Herzegovina: January - July, 2020. Bosn. J. Basic Med. Sci. (IF 2.05) Pub Date : 2020-10-21 Mirsada Hukic; Mirza Ponjavic; Emin Tahirovic; Almir Karabegovic; Elvir Ferhatbegovic; Maja Travar; Fadila Serdarevic
Between March 5 and July 25, 2020, the total number of SARS-CoV-2 confirmed cases in Bosnia and Herzegovina (BH) was 10 090 corresponding to a cumulative incidence rate of 285.7 per 100 000 population. Demographic and clinical information on all the cases along with exposure and contact information was collected using a standardized case report form. In suspected SARS-CoV-2 cases, respiratory specimens
-
The Ki-67 proliferation index predicts recurrence-free survival in patients with dermatofibrosarcoma protuberans. Bosn. J. Basic Med. Sci. (IF 2.05) Pub Date : 2020-10-20 Deligonul Adem; Serkan Yazici; Mine Ozsen; Sibel Kahraman Cetintas; Ulviye Yalcinkaya; Ahmet Bilgehan Şahin; Ozgur Tanrıverdi; Sibel Oyucu Orhan; Birol Ocak; Erdem Cubukcu; Ramazan Kahveci; Turkkan Evrensel
Dermatofibrosarcoma protuberans (DFSP) is an uncommon soft tissue sarcoma that originates from the dermis or subcutaneous tissue in the skin. While its prognosis is generally favorable, disease recurrence is relatively frequent. Because morbidity after repeated surgery may be significant, an optimized prediction of recurrence-free survival (RFS) has the potential to improve current management strategies
-
Alectinib and lorlatinib function by modulating EMT-related proteins and MMPs in NSCLC metastasis. Bosn. J. Basic Med. Sci. (IF 2.05) Pub Date : 2020-10-20 Xu Feng; En-Shi Xu
Most advanced non-small cell lung cancer (NSCLC) patients are accompanied by brain metastasis which is the major cause of increased mortality. The fusion rearrangement of anaplastic lymphoma kinase (ALK) gene is an important feature of brain metastasis in lung cancer. The novel ALK inhibitors alectinib and lorlatinib are shown to be effective against NSCLC brain metastasis, while their underlying mechanism
-
Development and validation of prognostic nomogram for lung cancer patients below the age of 45 years. Bosn. J. Basic Med. Sci. (IF 2.05) Pub Date : 2020-10-14 Kaixin Qu; Lili Dai; Wei Wang; Qi Liu; Tongjia Xia; Qikui Wang; Qingqing Chen; Ning Zhu; Yu Cheng; Ying Yan; Jun Shu
This study aimed to establish a nomogram for the prognostic prediction of patients with early-onset lung cancer (EOLC) in both overall survival (OS) and cancer-specific survival (CSS). We retrieved EOLC patients diagnosed between 2004 and 2015 from the Surveillance, Epidemiology, and End Results (SEER) database and further divided them into training and validation sets randomly. The prognostic nomogram
-
Microsurgical resection of giant T11/T12 conus cauda equine schwannoma. Bosn. J. Basic Med. Sci. (IF 2.05) Pub Date : 2020-10-14 Alisa Arnautovic; Mirza Pojskic; Kenan Arnautovic
In this video, we highlight the anatomy involved with microsurgical resection of a giant T11/T12 conus cauda equine schwannoma. Spinal schwannoma remains the third most common intradural spinal tumor. Tumors undergoing gross total resection usually do not recur. To our knowledge, this is the first video case report of giant cauda equina schwannoma resection. A 55-year-old female presented with paraparesis
-
Increasing the efficiency of mechanical ventilators during pandemics through additive manufacturing. Bosn. J. Basic Med. Sci. (IF 2.05) Pub Date : 2020-09-28 Abdullatif Alwasel; Jean Zaky; Khalid Alhussaini; Bandr Alossimi; Turki Alharbi
COVID-19 pandemic tested medical facilities readiness in terms of number of available mechanical ventilators. Most countries raced to stock up on ventilators, which created a surge in demand and short in supply. Other means of coping with the demand were proposed, such as using additive manufacturing. This paper is to test whether the addition of 3D printed splitters would help deliver required tidal
-
Cryptic t(15;17) acute promyelocytic leukemia with a karyotype of add(11)(p15) and t(13,20)- A case report with a literature review. Bosn. J. Basic Med. Sci. (IF 2.05) Pub Date : 2020-10-09 Siyu Gu; Jie Zi; Jinlong Ma; Zheng Ge
Most acute promyelocytic leukemia (APL) are characterized by reciprocal translocations t(15;17)(q22;21), which results in the fusion of PML gene at 15q22 with RARα gene at 17q21. However, several complex variant translocations also have been reported. Here we report a 62-year-old man with typical morphology and clinical features of APL with a complex karyotype including add(11)(p15) and t(13,20)(q12;q11
-
Dysbiosis of gut microbiota in inflammatory bowel disease: Current therapies and potential for microbiota-modulating therapeutic approaches. Bosn. J. Basic Med. Sci. (IF 2.05) Pub Date : 2020-09-21 Dikhnah Alshehri; Omar Saadah; Mahmoud Mosli; Sherif Edris; Rashad Alhindi; Ahmed Bahieldin
There is a growing body of evidence reinforcing the unique connections between the host microbiome, health and diseases. Due to the extreme importance of the symbiotic relationship between the intestinal microbiome and the host, it is not surprising that any alteration in the gut microbiota would result in various diseases, including inflammatory bowel disease (IBD), Crohn's disease (CD) and ulcerative
-
Postoperative respiratory depression after hysterectomy. Bosn. J. Basic Med. Sci. (IF 2.05) Pub Date : 2020-09-15 Mariana L Laporta,Michelle O Kinney,Darrell R Schroeder,Juraj Sprung,Toby N Weingarten
To investigate if sex-specific physiologic characteristics could impact postoperative respiratory depression risks in women, we studied incidence and risk factors associated with postoperative respiratory depression in a gynecologic surgical cohort. Only hysterectomies performed under general anesthesia from 2012 to 2017 were included to minimize interprocedural variability. Respiratory depression
-
An insight into osteoarthritis susceptibility: Integration of immunological and genetic background. Bosn. J. Basic Med. Sci. (IF 2.05) Pub Date : 2020-09-11 Debora Stefik,Vladimir Vranic,Nemanja Ivkovic,Dzihan Abazovic,Dusan Maric,Danilo Vojvodic,Gordana Supic
Osteoarthritis (OA) is a progressive degenerative disease that affects all synovial joints, causing the disability of the main locomotor diarthrodial joints. OA pathogenesis is caused by a complex interplay between a number of genetic and environmental risk factors, involved in the early onset and progression of this chronic inflammatory joint disease. Uncovering the underlying immunological and genetic
-
LncRNA SENCR suppresses abdominal aortic aneurysm formation by inhibiting smooth muscle cells apoptosis and extracellular matrix degradation. Bosn. J. Basic Med. Sci. (IF 2.05) Pub Date : 2020-09-08 Zhou Cai,Jianhua Huang,Junxiao Yang,Baihong Pan,Wei Wang,Yangyang Ou,Xianwei Wang,Pu Yang
Abdominal aortic aneurysm (AAA) is a progressive chronic dilatation of the abdominal aorta without effective medical treatment. This study aims to clarify the potential of long non-coding RNA SENCR as a treatment target in AAA. Angiotensin II (Ang-II) was used to establish AAA mouse model as well as a cell model based on the mouse aortic vascular smooth muscle cells (VSMCs). Reverse transcription quantitative
-
The value of lymphocyte count in determining the severity of COVID-19 and estimating the time for nucleic acid test results to turn negative. Bosn. J. Basic Med. Sci. (IF 2.05) Pub Date : 2020-09-07 Yuanchao Li,Tuoyun Yang,Sicong Wang,Junbo Zheng,Jing Zhou,Min Jiang,Tong Zhou,Yang Cao,Hongliang Wang
Peripheral blood lymphocyte count is shown to be decreased in patients with COVID-19 in the early stage of the disease. The degree of lymphocyte count reduction is related to COVID-19 severity and could be used as an indicator to reflect the disease severity. Our aim was to investigate the value of lymphocyte count in determining COVID-19 severity and estimating the time for SARS-CoV-2 nucleic acid
-
Cross-sectional imaging and cytologic investigations in the preoperative diagnosis of parotid gland tumors - an updated literature review. Bosn. J. Basic Med. Sci. (IF 2.05) Pub Date : 2020-09-01 Sebastian Stoia,Grigore Băciuț,Manuela Lenghel,Radu Badea,Csaba Csutak,Georgeta Mihaela Rusu,Mihaela Băciuț,Tiberiu Tamaș,Emil Boțan,Gabriel Armencea,Simion Bran,Cristian Dinu
An accurate preoperative diagnosis of parotid tumors is essential for selection and planning of the surgical treatment. Various modern cross-sectional imaging and cytologic investigations can support differential diagnosis of parotid tumors. The aim of this study was to achieve a comprehensive and updated review of modern imaging and cytologic investigations used in parotid tumor diagnosis, based on
-
Safety and effectiveness of new embolization microspheres SCBRM for intermediate-stage hepatocellular carcinoma: A feasibility study. Bosn. J. Basic Med. Sci. (IF 2.05) Pub Date : 2020-08-25 Yi-Sheng Liu,Xi-Zhang Lin,Chiung-Yu Chen,Yen-Cheng Chiu,Jui-Wen Kang,Hung-Wen Tsai,Hui-Yu Hung,Chi-Ming Ho,Ming-Ching Ou
Transarterial chemoembolization (TACE) is currently the recommended treatment for hepatocellular carcinoma (HCC). However, long-term chemoembolization triggers the inflammatory response and may lead to postembolization syndrome (PES). Although several types of degradable microspheres have been developed to reduce drug toxicity and PES incidence, the clinical outcomes remain unsatisfactory. Previously
-
Pharmacogenomics biomarkers for personalized methadone maintenance treatment: The mechanism and its potential use. Bosn. J. Basic Med. Sci. (IF 2.05) Pub Date : 2020-08-11 Fitri Fareez Ramli
Methadone has a wide pharmacokinetic interindividual variability, resulting in unpredicted treatment response. Pharmacogenomic biomarkers seem promising for personalized methadone maintenance treatment. The evidence supports the use of ABCB1 single-nucleotide polymorphism (SNP) 1236C>T with genotypes C/T or C/C (Jewish) and haplotypes AGCTT carrier, AGCGC heterozygote, or non-carrier (Caucasian), which
-
The Kampo medicine Yokukansan (YKS) enhances nerve growth factor (NGF)-induced neurite outgrowth in PC12 cells. Bosn. J. Basic Med. Sci. (IF 2.05) Pub Date : 2018-08-01 Kazuki Terada,Yukari Matsushima,Kazuhisa Matsunaga,Jiro Takata,Yoshiharu Karube,Atsushi Ishige,Koji Chiba
Accumulating evidence indicates that neurotrophic factor-like substances involved in the induction of neurotrophic factor synthesis may aid in the treatment of neurological disorders, such as Alzheimer's disease. Yokukansan (YKS), a traditional Kampo medicine, has been used for the treatment of anxiety and mood disorders. In the present study, we aimed to identify the signaling pathways associated
-
Safety of once- or twice-daily dosing of non-vitamin K antagonist oral anticoagulants (NOACs) in patients with nonvalvular atrial fibrillation: A NOAC-TR study. Bosn. J. Basic Med. Sci. (IF 2.05) Pub Date : 2018-05-20 Sadık Volkan Emren,Mehdi Zoghi,Rida Berilgen,İbrahim Halil Özdemir,Oğuzhan Çelik,Nurullah Çetin,Asım Enhoş,Cemal Köseoğlu,Abdurrahman Akyüz,Volkan Doğan,Fatih Levent,Yüksel Dereli,Tolga Doğan,Özcan Başaran,Ilgın Karaca,Özkan Karaca,Yılmaz Ömür Otlu,Çağlar Özmen,Selvi Coşar,Mutlu Sümerkan,Erdal Gürsul,Sinan İnci,Ersel Onrat,Oktay Ergene
Once-daily dosing of non-vitamin K antagonist oral anticoagulants (NOACs) may increase patient adherence to treatment but may also be associated with a higher risk of bleeding. In this study, we investigated the adherence to once- or twice-daily dosing of NOACs and the risk of bleeding in nonvalvular atrial fibrillation (NVAF) patients. This multicenter cross-sectional study, conducted between 1 September
-
Oligoasthenoteratozoospermic (OAT) men display altered phospholipase C ζ (PLCζ) localization and a lower percentage of sperm cells expressing PLCζ and post-acrosomal sheath WW domain-binding protein (PAWP). Bosn. J. Basic Med. Sci. (IF 2.05) Pub Date : 2018-05-20 Nahid Azad,Hamid Nazarian,Marefat Ghaffari Novin,Reza Masteri Farahani,Abbas Piryaei,Mohammad Hassan Heidari,Meghdad Abdollahpour Alitappeh
Oligoasthenoteratozoospermia (OAT) is demonstrated to be one of the most common causes of male subfertility. Phospholipase C ζ (PLCζ), a sperm-specific protein, is considered to be one of the sperm-borne oocyte activating factors (SOAFs), which play a vital role in fertilization. The post-acrosomal sheath WW domain-binding protein (PAWP) is another candidate for SOAF. The aim of this study was to compare
-
5-fluorouracil, leucovorin, and irinotecan (FOLFIRI) as a third-line chemotherapy treatment in metastatic gastric cancer, after failure of fluoropyrimidine, platinum, anthracycline, and taxane. Bosn. J. Basic Med. Sci. (IF 2.05) Pub Date : 2018-05-20 Gokmen Umut Erdem,Yakup Bozkaya,Nuriye Yildirim Ozdemir,Nebi Serkan Demirci,Ozan Yazici,Nurullah Zengin
Studies on the effects of third-line chemotherapy (CT) in advanced gastric cancer (GC) patients are still scarce. The aim of this study was to evaluate the efficacy and safety of the modified 5-fluorouracil, leucovorin, and irinotecan (mFOLFIRI) regimen as a third-line CT in metastatic GC patients, after failure of fluoropyrimidine, platinum, anthracycline, and taxane. After failure of first- and second-line
-
Efficacy of a bundle approach in preventing the incidence of ventilator associated pneumonia (VAP). Bosn. J. Basic Med. Sci. (IF 2.05) Pub Date : 2018-02-20 Sandra Burja,Tina Belec,Nika Bizjak,Jernej Mori,Andrej Markota,Andreja Sinkovič
Ventilator-associated pneumonia (VAP) is a potentially preventable iatrogenic illness that may develop following mechanical ventilation. A bundle for the prevention of VAP consists of different measures which may vary between institutions, and may include: elevation of the head of the bed, oral care with chlorhexidine, subglottic suctioning, daily assessment for extubation and the need for proton-pump
-
Etoricoxib improves osteoarthritis pain relief, joint function, and quality of life in the extreme elderly. Bosn. J. Basic Med. Sci. (IF 2.05) Pub Date : 2018-02-20 Wen-Nan Huang,Tim K Tso
Etoricoxib is a selective cyclooxygenase-2 inhibitor, with a lower risk of gastrointestinal toxicity compared to traditional nonsteroidal anti-inflammatory drugs (NSAIDs). We evaluated the effectiveness and tolerability of etoricoxib in extremely elderly patients with chronic pain due to osteoarthritis (OA). A prospective, single-center, single-arm study was conducted, enrolling 19 extremely elderly
-
Physiological and transcriptomic analysis of a salt-resistant Saccharomyces cerevisiae mutant obtained by evolutionary engineering. Bosn. J. Basic Med. Sci. (IF 2.05) Pub Date : 2018-02-20 Seyma Hande Tekarslan-Sahin,Ceren Alkim,Tugba Sezgin
Salt-resistant yeast strains are highly demanded by industry due to the exposure of yeast cells to high concentrations of salt, in various industrial bioprocesses. The aim of this study was to perform a physiological and transcriptomic analysis of a salt-resistant Saccharomyces cerevisiae (S. cerevisiae) mutant generated by evolutionary engineering. NaCl-resistant S. cerevisiae strains were obtained
-
Vitamin D status, serum lipid concentrations, and vitamin D receptor (VDR) gene polymorphisms in Familial Mediterranean fever. Bosn. J. Basic Med. Sci. (IF 2.05) Pub Date : 2018-02-20 Turan Turhan,Halef Okan Doğan,Nihal Boğdaycioğlu,Nilnur Eyerci,Ahmet Omma,İsmail Sari,Ahmet Yeşilyurt,Yaşar Karaaslan
Vitamin D (VitD) is critical for the regulation of inflammatory processes, and VitD deficiency has been linked to several chronic inflammatory disorders. We aimed to investigate the concentrations of serum 25(OH)D3, lipid parameters, and three known VDR polymorphisms (BsmI, FokI, and TaqI) in patients with Familial Mediterranean fever (FMF), an autosomal recessive autoinflammatory disease. The study
-
Evaluation of platelet activation in leukocyte-depleted platelet concentrates during storage. Bosn. J. Basic Med. Sci. (IF 2.05) Pub Date : 2018-02-20 Miodrag Vucic,Zoran Stanojkovic,Ana Antic,Jelana Vucic,Voja Pavlovic
Structural and functional changes in platelets during storage can lead to the loss of platelet reactivity and response. Our aim was to evaluate leukocyte-depleted platelet concentrates on storage days 0, 3 and 5, obtained by in-line filtration. In non-filtered platelet concentrates (NF-PC) group, 180 whole blood units were collected with quadruple blood bags and then compared to another group of 180
-
The joint effect of the endothelin receptor B gene (EDNRB) polymorphism rs10507875 and nitric oxide synthase 3 gene (NOS3) polymorphism rs869109213 in Slovenian patients with type 2 diabetes mellitus and diabetic retinopathy. Bosn. J. Basic Med. Sci. (IF 2.05) Pub Date : 2018-02-20 Dejan Bregar,Ines Cilenšek,Sara Mankoč,Ana Reschner,Danijel Petrovič,Mojca Globočnik Petrovič
Increasing evidence suggests that endothelin and nitric oxide synthase genes and their products exert biological effects on the vasculature via the nitric oxide or endothelin pathway. The aim of the study was to evaluate the association of rs10507875 and rs869109213 (alone or in interaction) with diabetic retinopathy (DR) in subjects with type 2 diabetes mellitus (T2DM). We genotyped the single nucleotide
-
The value of 18F-FDG PET/CT imaging in breast cancer staging. Bosn. J. Basic Med. Sci. (IF 2.05) Pub Date : 2018-02-20 Ulkem Yararbas,Neslihan Cetin Avci,Levent Yeniay,Aziz Murat Argon
The National Comprehensive Cancer Network (NCCN) guidelines recommend assessment with positron emission tomography with 2-deoxy-2-[fluorine-18]fluoro-D-glucose integrated with computed tomography (18F-FDG PET/CT) in staging of breast cancer, starting from the stage IIIA. Previously, PET/CT contributed to the accurate staging from the stage IIB. Our aim is to evaluate the contribution of 18F-FDG PET/CT
-
Adapted methods for scanning electron microscopy (SEM) in assessment of human sperm morphology. Bosn. J. Basic Med. Sci. (IF 2.05) Pub Date : 2018-02-20 Petra Nussdorfer,Ines Cilenšek,Branko Zorn,Daniel Petrovič
Infertility is a widespread problem, and in some cases, the routine basic semen analysis is not sufficient to detect the cause of male infertility. The use of the scanning electron microscope (SEM) could provide a detailed insight into spermatozoa morphology, but it requires specific sample preparation techniques. The purpose of this study was to select, adjust, and optimize a method for the preparation
-
Evaluation of pulmonary artery pressure in patients with juvenile systemic lupus erythematosus (jSLE). Bosn. J. Basic Med. Sci. (IF 2.05) Pub Date : 2018-02-20 Amra Adrovic,Reyhan Dedeoglu,Sezgin Sahin,Kenan Barut,Aida Koka,Dicle Cengiz,Funda Oztunc,Ozgur Kasapcopur
Juvenile systemic lupus erythematosus (jSLE) is a chronic multisystemic autoimmune disease. Previous studies among adults have shown impaired right ventricular (RV) function in patients with SLE. Also, these patients may develop pulmonary artery hypertension (PAH), which is one of the most threatening complications of SLE. Nevertheless, studies on PAH among jSLE patients are still rare. The aim of
-
The effect of metformin treatment on endoplasmic reticulum (ER) stress induced by status epilepticus (SE) via the PERK-eIF2α-CHOP pathway. Bosn. J. Basic Med. Sci. (IF 2.05) Pub Date : 2018-02-20 Jing Chen,Guo Zheng,Hu Guo,Zhong-Nan Shi,Jiao Jiang,Xiao-Yu Wang,Xiao Yang,Xian-Yu Liu
Status epilepticus (SE) is defined as continuous seizure activity lasting more than 5 minutes. It results in neuronal cell death, mediated by endoplasmic reticulum (ER) stress response. Previously, metformin demonstrated neuroprotective effects in primary cortical neurons. In this study, we analyzed the effect of metformin on ER stress via the pro-apoptotic protein kinase RNA-like endoplasmic reticulum
-
Differential diagnosis of hepatopulmonary syndrome (HPS): Portopulmonary hypertension (PPH) and hereditary hemorrhagic telangiectasia (HHT). Bosn. J. Basic Med. Sci. (IF 2.05) Pub Date : 2017-11-20 Inna Krynytska,Mariya Marushchak,Anna Mikolenko,Anzhela Bob,Iryna Smachylo,Ludmyla Radetska,Olga Sopel
Hepatopulmonary syndrome (HPS) is a severe complication of advanced liver disease associated with an extremely poor prognosis. HPS is diagnosed in 4-47% of patients with cirrhosis and in 15-20% of candidates for liver transplantation. In addition, severe hypoxia is associated with a high risk of complications of liver transplantation (a 30% chance during the first 90 days) and increases the gap between
-
ABCB1 3435C>T and 2677G>T/A polymorphisms in Polish and Bosnian patients with Crohn's disease - A preliminary report. Bosn. J. Basic Med. Sci. (IF 2.05) Pub Date : 2017-11-20 Krzysztof Borecki,Iwona Zawada,Anna Pawinska-Matecka,Nermin Nusret Salkic,Beata Karakiewicz,Grażyna Adler
The role of ABCB1 single nucleotide polymorphisms (SNPs) in the development of Crohn's disease (CD) remains unclear. Due to inconsistent results of several European population-based studies and limited information on populations from Poland and Bosnia and Herzegovina (B&H), we conducted a preliminary association study of two main ABCB1 SNPs and CD. ABCB1 3435C>T and 2677G>T/A SNPs were analyzed in
-
Enhancer of zeste homologue 2 (EZH2) expression in synovial sarcomas as a promising indicator of prognosis. Bosn. J. Basic Med. Sci. (IF 2.05) Pub Date : 2017-11-20 Ulviye Yalçınkaya,Nesrin Uğraş,Gonca Özgün,Gökhan Ocakoğlu,Adem Deligönül,Sibel Kahraman Çetintaş,Muhammed Sadık Bilgen
Synovial sarcoma (SS) is a type of soft-tissue sarcoma, often linked to poor survival. Although overexpression of enhancer of zeste homologue 2 (EZH2) has been associated with poor prognosis in different tumors, a few studies investigated this link in SS. Here, we analyzed the relationship between EZH2 expression and prognostic factors in SS. We included 29 patients with SS. Immunostaining of EZH2
-
Lack of association between urotensin-II (UTS2) gene polymorphisms (Thr21Met and Ser89Asn) and migraine. Bosn. J. Basic Med. Sci. (IF 2.05) Pub Date : 2017-08-20 Betül Ozan,Seniz Demiryürek,Muhammad Safdar,Yusuf Inanc,Abdullah Tuncay Demiryürek
Migraine is a common neurovascular brain disorder with heterogeneous clinical presentation, including recurrent headache attacks. The pathophysiology of migraine is complex, and a number of genomic regions have been associated with the development of migraine. In this study, we analyzed the allele and genotype frequencies of the urotensin-II gene (UTS2) polymorphisms, Thr21Met and Ser89Asn, among Turkish
-
Modulatory effect of curcumin on ketamine-induced toxicity in rat thymocytes: Involvement of reactive oxygen species (ROS) and the phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt) pathway. Bosn. J. Basic Med. Sci. (IF 2.05) Pub Date : 2018-11-07 Svetlana Pavlovic,Zorica Jovic,Radmila Karan,Dane Krtinic,Gorana Rankovic,Mladjan Golubovic,Jelena Lilic,Voja Pavlovic
Ketamine is a widely used anesthetic in pediatric clinical practice. Previous studies have demonstrated that ketamine induces neurotoxicity and has a modulatory effect on the cells of the immune system. Here, we evaluated the potential protective effect and underlying mechanisms of natural phenolic compound curcumin against ketamine-induced toxicity in rat thymocytes. Rat thymocytes were exposed to
-
The effect of 131I-induced hypothyroidism on the levels of nitric oxide (NO), interleukin 6 (IL-6), tumor necrosis factor alpha (TNF-α), total nitric oxide synthase (NOS) activity, and expression of NOS isoforms in rats. Bosn. J. Basic Med. Sci. (IF 2.05) Pub Date : 2018-11-07 Jing Zhou,Gang Cheng,Hua Pang,Qian Liu,Ying Liu
Accumulating evidence has shown that hypothyroidism affects the cardiovascular system, significantly increasing the incidence of cardiovascular diseases. In the present study we investigated the effect of radioactive iodine (I-131)-induced hypothyroidism on several parameters of vascular function, such as nitric oxide (NO), total nitric oxide synthase (NOS) activity and expression of NOS isoforms,
-
Interleukin-4 (IL4) -590C/T (rs2243250) gene polymorphism is not associated with diabetic nephropathy (DN) in Caucasians with type 2 diabetes mellitus (T2DM). Bosn. J. Basic Med. Sci. (IF 2.05) Pub Date : 2018-11-07 Matej Završnik,Jernej Letonja,Jana Makuc,Maja Šeruga,Ines Cilenšek,Daniel Petrovič
Diabetic nephropathy (DN) is a microvascular complication that affects up to 40% of diabetic patients and can lead to end-stage kidney disease. Inflammatory cytokines such as interleukin 1 (IL-1), IL-6, IL-18 and tumor necrosis factor-α (TNFα) have been linked to the development and progression of DN. The aim of our study was to examine the relationship between interleukin-4 (IL4) -590C/T (rs2243250)
-
Non-endoscopic minimally invasive evacuation of intracerebral hematoma (ICH): A case report. Bosn. J. Basic Med. Sci. (IF 2.05) Pub Date : 2018-11-07 Tomaz Velnar
Spontaneous intracerebral hemorrhage (ICH) is one of the most serious causes of stroke, leading to high rates of disability and mortality. In addition to intensive medical treatment, surgery may help to improve the prognosis in patients with ICH. A rapid reversal of coagulopathy is essential in these patients, although it may be difficult to achieve in various bleeding disorders. In such cases, when
-
Histological observations on adipocere in human remains buried for 21 years at the Tomašica grave-site in Bosnia and Herzegovina. Bosn. J. Basic Med. Sci. (IF 2.05) Pub Date : 2018-08-01 Adis Salihbegović,John Clark,Nermin Sarajlić,Svjetlana Radović,Finlay Finlay,Anes Jogunčić,Emina Spahić,Vedo Tuco
The Tomašica grave-site near Prijedor in the north of Bosnia is reported to be the largest primary mass grave discovered thus far relating to the 1992-95 war. A total of 275 complete bodies and 125 body parts were exhumed from it in 2013. Post mortem examinations of the victims showed that nearly all had died from gunshot injuries but an additional striking feature was the degree of preservation of
-
Control of body temperature and immune function in patients undergoing open surgery for gastric cancer. Bosn. J. Basic Med. Sci. (IF 2.05) Pub Date : 2018-08-01 Li Shao,Nannan Pang,Ping Yan,Fengju Jia,Qi Sun,Wenjuan Ma,Yi Yang
The influence of mild perioperative hypothermia on the immune function and incidence of postoperative wound infections has been suggested, but the specific mechanism is unclear. This study aimed to analyze the body temperature, immune function, and wound infection rates in patients receiving open surgery for gastric cancer. Body temperature was controlled in each patient using one of four different
-
Analysis of the association between CFH Y402H polymorphism and response to intravitreal ranibizumab in patients with neovascular age-related macular degeneration (nAMD). Bosn. J. Basic Med. Sci. (IF 2.05) Pub Date : 2018-08-01 Nur Afiqah Mohamad,Vasudevan Ramachandran,Patimah Ismail,Hazlita Mohd Isa,Yoke Mun Chan,Nor Fariza Ngah,Norshakimah Md Bakri,Siew Mooi Ching,Fan Kee Hoo,Wan Aliaa Wan Sulaiman,Liyana Najwa Inche Mat,Mohd Hazmi Mohamed
Pharmacogenetic studies indicate that a variable response to anti-vascular endothelial growth factor (VEGF) therapy in patients with neovascular form of AMD (nAMD) may be due to polymorphisms in the complement factor H gene (CFH). This study is the first to investigate the association between CFH Y402H polymorphism and the response to ranibizumab therapy in Malaysian patients with nAMD. We included
-
MicroRNA-466 (miR-466) functions as a tumor suppressor and prognostic factor in colorectal cancer (CRC). Bosn. J. Basic Med. Sci. (IF 2.05) Pub Date : 2018-08-01 Feng Tong,Youhua Ying,Haihua Pan,Wei Zhao,Hongchen Li,Xiaoli Zhan
MicroRNAs (miRNAs) have an important role in the regulation of tumor development and metastasis. In this study, we investigated the clinical and prognostic value as well as biological function of miR-466 in colorectal cancer (CRC). Tumor and adjacent healthy tissues were obtained from 100 patients diagnosed with CRC. miR-466 expression was determined by quantitative reverse transcription polymerase
-
Therapeutic role of methotrexate in pediatric Crohn's disease. Bosn. J. Basic Med. Sci. (IF 2.05) Pub Date : 2018-08-01 Zlatko Djurić,Ljiljana Šaranac,Ivana Budić,Voja Pavlović,Jelena Djordjević
The main role of therapy in Crohn's disease (CD) is to achieve long-term clinical remission, and to allow for normal growth and development of children. The immunomodulatory drugs used for the maintenance of remission in CD include thiopurines (azathioprine and 6-mercaptopurine) and methotrexate (MTX). Development of hepatosplenic T-cell lymphoma in some patients with inflammatory bowel disease, treated
-
The clinical characteristics and surgical approach of scar endometriosis: A case series of 14 women. Bosn. J. Basic Med. Sci. (IF 2.05) Pub Date : 2018-08-01 Faik Tatli,Orhan Gozeneli,Hacer Uyanikoglu,Ali Uzunkoy,Huseyin Cahit Yalcın,Abdullah Ozgonul,Osman Bardakci,Adnan Incebiyik,Muhammet Emin Guldur
Scar endometriosis, also referred to as abdominal wall endometriosis (AWE), is a rare form of endometriosis that usually develops in the scar after obstetric or gynecological surgeries, including cesarean section (CS). Recently, the occurrence of scar endometriosis has been increasing together with the increase of CS incidence. Scar endometriosis can be clinically misdiagnosed as hernia, lipoma, or