Heparin, a sulfate-containing linear polysaccharide, has proven preclinical and clinical efficacy for a variety of disorders. Heparin, including unfractionated heparin (UFH), low-molecular-weight heparin (LMWH), and ultra-low-molecular-weight heparin (ULMWH), is administered systematically, in the form of a solution in the clinic. However, it is eliminated quickly, due to its short half-life, especially

A green method for the production of cobalt/(TEMPO-Cell) aerogel heterogeneous catalyst was developed. The preparation implied the reduction of CoSO4 by NaBH4 in TEMPO-Cell water dispersion in ambient conditions. The formation of Cobalt particles is due to the presence of “TEMPO-CELL” which screens the Co2+ ions and prevents their combination with boron. SEM, XRD, EDX, FTIT, TEM and XPS were used to

Hydrogels are materials consisting in a three-dimensional hydrophilic polymer network swollen by a large amount of water. An efficient strategy to elaborate hydrogels consists in establishing double polymer networks in order to achieve high strengthening effect associated with other properties such as transparency or tailored swelling capacities. In this work, we prepared cellulose nanocrystals (CNC)-based

A facile method was designed that can specifically deliver CRISPR/Cas9 into target cells nuclei and reduce the off-target effects. A multifunctional delivery vector for FOXM1 knockout was composed by integration of cell targeting polymer (hyaluronic acid) and cell and nuclear targeting group (AS1411 aptamer) on the surface of nanoparticles formed by genome editing plasmid and chitosan (CS) as the core