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  • A pathway to keep all lifelong learners up to date: the ERS continuing professional development programme
    Eur. Respir. J. (IF 11.807) Pub Date : 2020-02-01
    Amy Farr; Stefano Aliberti; Stelios Loukides; Gilbert Massard; Robert Primhak; Gernot G.U. Rohde; Nathalie Tabin; Carine Pannetier; Daiana Stolz

    Albert Einstein's philosophy on lifelong learning was that intellectual growth should commence at birth and cease only at death. Yet in reality, across the board, the foundations of our education systems encourage individual learners early in life to choose a particular path or specialty in a structured way, and then provide little guidance for ongoing development at a more mature stage of their careers

    更新日期:2020-02-27
  • Minimising the environmental impact of inhaled therapies: problems with policy on low carbon inhalers
    Eur. Respir. J. (IF 11.807) Pub Date : 2020-02-01
    Duncan Keeley; Jane E. Scullion; Omar S. Usmani

    As global citizens, we have a duty to reduce the serious threats posed to planetary well-being and population health by environmental degradation and climate change. These now unquestionable threats to our future are due to human population growth and the resource consumption patterns of the human race. In tandem, as healthcare professionals, we should seek the best possible outcomes of our treatment

    更新日期:2020-02-27
  • Troponin as a biomarker for mortality in stable COPD
    Eur. Respir. J. (IF 11.807) Pub Date : 2020-02-01
    Ulf Nilsson; Lowie E.G.W. Vanfleteren

    COPD is a leading cause of death in the world. COPD represents the pulmonary component of multimorbidity, often with cardiovascular disease (CVD) as the most prevalent, and possibly the most clinically relevant [1]. Indeed, cardiovascular diseases affect quality of life and healthcare costs, and are a major cause of death in COPD [2, 3]. The Global Initiative for Chronic Obstructive Lung Disease (GOLD

    更新日期:2020-02-27
  • Exhaled volatile organic compounds for better asthma control: could it be a future noninvasive adherence test?
    Eur. Respir. J. (IF 11.807) Pub Date : 2020-02-01
    Florence N. Schleich; Delphine Zanella; Jean-François Focant

    In the study presented in this issue of the European Respiratory Journal , Brinkman et al. [1] investigated the link between traces of asthma medication in urine of severe asthmatic patients and exhaled volatile organic compounds (VOCs). One potential application of this study in clinical practice would be an easy, indirect measurement of compliance using detection of exhaled breath biomarkers resulting

    更新日期:2020-02-27
  • Technical standards for respiratory oscillometry
    Eur. Respir. J. (IF 11.807) Pub Date : 2020-02-01
    Gregory G. King; Jason Bates; Kenneth I. Berger; Peter Calverley; Pedro L. de Melo; Raffaele L. Dellacà; Ramon Farré; Graham L. Hall; Iulia Ioan; Charles G. Irvin; David W. Kaczka; David A. Kaminsky; Hajime Kurosawa; Enrico Lombardi; Geoffrey N. Maksym; François Marchal; Beno W. Oppenheimer; Shannon J. Simpson; Cindy Thamrin; Maarten van den Berge; Ellie Oostveen

    Oscillometry (also known as the forced oscillation technique) measures the mechanical properties of the respiratory system (upper and intrathoracic airways, lung tissue and chest wall) during quiet tidal breathing, by the application of an oscillating pressure signal (input or forcing signal), most commonly at the mouth. With increased clinical and research use, it is critical that all technical details

    更新日期:2020-02-27
  • High-sensitivity troponin I and all-cause mortality in patients with stable COPD: an analysis of the COSYCONET study
    Eur. Respir. J. (IF 11.807) Pub Date : 2020-02-01
    Benjamin Waschki; Peter Alter; Tanja Zeller; Christina Magnussen; Johannes T. Neumann; Raphael Twerenbold; Christoph Sinning; Christian Herr; Kathrin Kahnert; Sebastian Fähndrich; Stefan Blankenberg; Klaus F. Rabe; Tobias Welte; Rudolf A. Jörres; Claus F. Vogelmeier; Robert Bals; Henrik Watz

    Chronic obstructive pulmonary disease (COPD) is a leading cause of death with a considerable part of the population dying from cardiovascular diseases. High-sensitivity troponin I (hs-TnI) might help to better identify COPD patients at high risk of mortality. We aimed to study the predictive value of hs-TnI for all-cause mortality beyond established COPD assessments, and after consideration of relevant

    更新日期:2020-02-27
  • Exhaled volatile organic compounds as markers for medication use in asthma
    Eur. Respir. J. (IF 11.807) Pub Date : 2020-02-01
    Paul Brinkman; Waqar M. Ahmed; Cristina Gómez; Hugo H. Knobel; Hans Weda; Teunis J. Vink; Tamara M. Nijsen; Craig E. Wheelock; Sven-Erik Dahlen; Paolo Montuschi; Richard G. Knowles; Susanne J. Vijverberg; Anke H. Maitland-van der Zee; Peter J. Sterk; Stephen J. Fowler

    Introduction Asthma is a heterogeneous condition, characterised by chronic inflammation of the airways, typically managed with inhaled bronchodilators and corticosteroids. In the case of uncontrolled asthma, oral corticosteroids (OCSs) are often prescribed. Good adherence and inhalation technique are associated with improved outcomes; however, it is difficult to monitor appropriate drug intake and

    更新日期:2020-02-27
  • PET/CT features of extrapulmonary tuberculosis at first clinical presentation: a cross-sectional observational 18F-FDG imaging study across six countries
    Eur. Respir. J. (IF 11.807) Pub Date : 2020-02-01
    Jamshed Bomanji; Rajnish Sharma; Bhagwant R. Mittal; Sanjay Gambhir; Ahmad Qureshy; Shamim M.F. Begum; Diana Paez; Mike Sathekge; Mariza Vorster; Dragana Sobic Saranovic; Pawana Pusuwan; Vera Mann; Sobhan Vinjamuri; Alimuddin Zumla; Thomas N.B. Pascual

    Background A large proportion of the huge global burden of extrapulmonary tuberculosis (EPTB) cases are treated empirically without accurate definition of disease sites and extent of multi-organ disease involvement. Positron emission tomography (PET) imaging using 2-deoxy-2-(fluorine-18) fluoro-d-glucose (18F-FDG) in tuberculosis could be a useful imaging technique for localising disease sites and

    更新日期:2020-02-27
  • Genetic landscape of adult Langerhans cell histiocytosis with lung involvement
    Eur. Respir. J. (IF 11.807) Pub Date : 2020-02-01
    Fanélie Jouenne; Sylvie Chevret; Emmanuelle Bugnet; Emmanuelle Clappier; Gwenaël Lorillon; Véronique Meignin; Aurélie Sadoux; Shannon Cohen; Alain Haziot; Alexandre How-Kit; Caroline Kannengiesser; Céleste Lebbé; Dominique Gossot; Samia Mourah; Abdellatif Tazi

    The clinical significance of the BRAF V600E mutation in adult Langerhans cell histiocytosis (LCH), including pulmonary Langerhans cell histiocytosis (PLCH), is not well understood. Similarly, the spectrum of molecular alterations involved in adult LCH has not been fully delineated. To address these issues, we genotyped a large number of adult LCH biopsies and searched for an association of identified

    更新日期:2020-02-27
  • Eight novel variants in the SLC34A2 gene in pulmonary alveolar microlithiasis
    Eur. Respir. J. (IF 11.807) Pub Date : 2020-02-01
    Åsa Lina M. Jönsson; Elisabeth Bendstrup; Susie Mogensen; Elizabeth J. Kopras; Francis X. McCormack; Ilaria Campo; Francesca Mariani; Amparo Escribano-Montaner; Are M. Holm; Maria del Mar Martinez-Colls; Guillem Pintos-Morell; Camille Taillé; Bruno Crestani; Ole Hilberg; Jane Hvarregaard Christensen; Ulf Simonsen

    Background Pulmonary alveolar microlithiasis (PAM) is caused by genetic variants in the SLC34A2 gene, which encodes the sodium-dependent phosphate transport protein 2B (NaPi-2b). PAM is characterised by deposition of calcium phosphate concretions (microliths) in the alveoli leading to pulmonary dysfunction. The variant spectrum of SLC34A2 has not been well investigated and it is not yet known whether

    更新日期:2020-02-27
  • Can circular RNAs be used as prenatal biomarkers for congenital diaphragmatic hernia?
    Eur. Respir. J. (IF 11.807) Pub Date : 2020-02-01
    Richard Wagner; Aruni Jha; Lojine Ayoub; Shana Kahnamoui; Daywin Patel; Thomas H. Mahood; Andrew J. Halayko; Martin Lacher; Christopher D. Pascoe; Richard Keijzer

    Since 2000, more than 400 000 babies worldwide have died of congenital diaphragmatic hernia (CDH), a condition that is occurring as frequently as cystic fibrosis and characterised by underdeveloped lungs (pulmonary hypoplasia), persistent pulmonary hypertension and a diaphragmatic defect [1]. CDH can be diagnosed prenatally with ultrasound and fetal MRI, but outcome prediction and diagnostic accuracy

    更新日期:2020-02-27
  • Inhaled corticosteroid use and the incidence of lung cancer in COPD
    Eur. Respir. J. (IF 11.807) Pub Date : 2020-02-01
    Samy Suissa; Sophie Dell'Aniello; Anne V. Gonzalez; Pierre Ernst

    Background Inhaled corticosteroids (ICS) are suggested for potential chemoprevention of lung cancer. Several observational studies in patients with chronic obstructive pulmonary disease (COPD) reported inconsistent results, either significant reductions in lung cancer incidence with ICS use or no effect. We assessed this association, using an approach that avoided biases affecting some of the studies

    更新日期:2020-02-20
  • Dietary antioxidant intake in school age and lung function development up to adolescence
    Eur. Respir. J. (IF 11.807) Pub Date : 2020-02-01
    Emmanouela Sdona; Jenny Hallberg; Niklas Andersson; Sandra Ekström; Susanne Rautiainen; Niclas Håkansson; Alicja Wolk; Inger Kull; Erik Melén; Anna Bergström

    Dietary antioxidant intake has been hypothesised to influence lung function. The association between total antioxidant capacity (TAC) of the diet at age 8 years and lung function development up to 16 years in 2307 participants from the Swedish population-based birth cohort BAMSE (Children, Allergy, Milieu, Stockholm, Epidemiology) was investigated. Information on TAC was obtained from a food frequency

    更新日期:2020-02-20
  • CX3CR1–fractalkine axis drives kinetic changes of monocytes in fibrotic interstitial lung diseases
    Eur. Respir. J. (IF 11.807) Pub Date : 2020-02-01
    Flavia R. Greiffo; Valeria Viteri-Alvarez; Marion Frankenberger; Daniela Dietel; Almudena Ortega-Gomez; Joyce S. Lee; Anne Hilgendorff; Jürgen Behr; Oliver Soehnlein; Oliver Eickelberg; Isis E. Fernandez

    Circulating immune cell populations have been shown to contribute to interstitial lung disease (ILD). In this study, we analysed circulating and lung resident monocyte populations, and assessed their phenotype and recruitment from the blood to the lung in ILD. Flow cytometry analysis of blood samples for quantifying circulating monocytes was performed in 105 subjects: 83 with ILD (n=36, n=28 and n=

    更新日期:2020-02-20
  • Airway G-CSF identifies neutrophilic inflammation and contributes to asthma progression
    Eur. Respir. J. (IF 11.807) Pub Date : 2020-02-01
    Young-Min Kim; Hyekang Kim; Seungwon Lee; Sora Kim; Jong-Uk Lee; Youngwoo Choi; Han Wook Park; Gihoon You; Hansol Kang; Seyoung Lee; Jong-Sook Park; Yunji Park; Hae-Sim Park; Choon-Sik Park; Seung-Woo Lee

    Stratification of asthmatic patients based on relevant biomarkers enables the prediction of responsiveness against immune-targeted therapies in patients with asthma. Individualised therapy in patients with eosinophilic asthma has yielded improved clinical outcomes; similar approaches in patients with neutrophilic asthma have yet to be developed. We determined whether colony-stimulating factors (CSFs

    更新日期:2020-02-20
  • Early life exposure to air pollution and incidence of childhood asthma, allergic rhinitis and eczema
    Eur. Respir. J. (IF 11.807) Pub Date : 2020-02-01
    Teresa To; Jingqin Zhu; Dave Stieb; Natasha Gray; Ivy Fong; Lauren Pinault; Michael Jerrett; Alain Robichaud; Richard Ménard; Aaron van Donkelaar; Randall V. Martin; Perry Hystad; Jeffrey R. Brook; Sharon Dell

    Rationale There is growing evidence that air pollution may contribute to the development of childhood asthma and other allergic diseases. In this follow-up of the Toronto Child Health Evaluation Questionnaire (T-CHEQ) study, we examined associations between early life exposures to air pollution and incidence of asthma, allergic rhinitis and eczema from birth through adolescence. Methods 1286 T-CHEQ

    更新日期:2020-02-20
  • Current perspectives on the role of interleukin-1 signalling in the pathogenesis of asthma and COPD
    Eur. Respir. J. (IF 11.807) Pub Date : 2020-02-01
    Emmanuel T. Osei; Corry-Anke Brandsma; Wim Timens; Irene H. Heijink; Tillie-Louise Hackett

    Asthma and chronic obstructive pulmonary disease (COPD) cause significant morbidity and mortality worldwide. In the context of disease pathogenesis, both asthma and COPD involve chronic inflammation of the lung and are characterised by the abnormal release of inflammatory cytokines, dysregulated immune cell activity and remodelling of the airways. To date, current treatments still only manage symptoms

    更新日期:2020-02-20
  • Attitudes of patients with chronic breathlessness towards treatment with opioids
    Eur. Respir. J. (IF 11.807) Pub Date : 2020-02-01
    Cornelia A. Verberkt; Marieke H.J. van den Beuken-van Everdingen; Emiel F.M. Wouters; Daisy J.A. Janssen

    Breathlessness is the most common symptom in advanced chronic lung disease or chronic heart failure (CHF) [1]. Opioids are recommended for palliative treatment of breathlessness persisting despite optimal pharmacological and non-pharmacological treatment [2, 3]. However, physicians don't always consider opioids for chronic breathlessness [4, 5] and experience barriers when considering opioids, such

    更新日期:2020-02-20
  • Physiological predictors of exertional oxygen desaturation in patients with fibrotic interstitial lung disease
    Eur. Respir. J. (IF 11.807) Pub Date : 2020-02-01
    Veronica Alfieri; Ernesto Crisafulli; Dina Visca; Wing Ho Chong; Carmel Stock; Letizia Mori; Angelo de Lauretis; Vicky Tsipouri; Felix Chua; Vasilis Kouranos; Maria Kokosi; Charlotte Hogben; Philip L. Molyneaux; Peter M. George; Toby M. Maher; Alfredo A. Chetta; Piersante Sestini; Athol U. Wells; Elisabetta A Renzoni

    In patients with fibrotic interstitial lung disease (ILD), hypoxaemia on exertion is frequent, and contributes to exercise intolerance, exertional dyspnoea and reduced quality of life [1–3]. Clinically significant exertional hypoxaemia is typically defined as a drop in transcutaneous arterial oxygen saturation ( S pO2) to ≤88% on a 6-min walk test (6MWT) [4], and is associated with reduced survival

    更新日期:2020-02-20
  • Discrepancies in reported versus measured nicotine content of e-cigarette refill liquids across nine European countries before and after the implementation of the EU Tobacco Products Directive
    Eur. Respir. J. (IF 11.807) Pub Date : 2020-02-01
    Charis Girvalaki; Manolis Tzatzarakis; Alexander Vardavas; Christina N. Kyriakos; Katerina Nikitara; Polychronis Stivaktakis; Aristidis Tsatsakis; Constantine Vardavas

    In recent years, the e-cigarette market across European countries has grown extensively [1, 2], as 15% of Europeans report having tried e-cigarettes, representing a 7.0% increase since 2012 [3]. E-cigarettes are regulated across the 28 European Union (EU) member states [4] under Article 20 of the Tobacco Products Directive (TPD), a legislative document which aims to regulate the internal European market

    更新日期:2020-02-20
  • Impact of marijuana smoking on lung function in older persons
    Eur. Respir. J. (IF 11.807) Pub Date : 2020-02-01
    Donald P. Tashkin; Michael D. Roth

    The investigation by Tan et al . [1] addresses an important question regarding the impact of marijuana smoking in middle-aged and older individuals and the relative risk for developing COPD and an accelerated rate of decline in lung function. The importance of this question is underscored by the spreading legalisation of marijuana and the likely impact on its use in both older and younger persons.

    更新日期:2020-02-20
  • Impact of marijuana smoking on lung function in older persons
    Eur. Respir. J. (IF 11.807) Pub Date : 2020-02-01
    Wan C. Tan; Jean Bourbeau; Shawn D. Aaron; Don D. Sin

    Most previous epidemiological studies support a significant association between marijuana smoking and chronic respiratory symptoms [1], but the effects on lung function remain unclear. Previous longitudinal cohort studies have focused largely on young adults [1]. The results from these studies have shown that marijuana smoking produced marginal or no effects on lung function, which is expected given

    更新日期:2020-02-20
  • Floating the invisible swan: noninvasive prediction of haemodynamics
    Eur. Respir. J. (IF 11.807) Pub Date : 2020-02-01
    Vineet Agrawal; Evan L. Brittain

    Pulmonary hypertension (PH) describes a heterogeneous set of diseases associated with increased morbidity and mortality, regardless of the aetiology [1–4]. The gold standard for diagnosing and phenotyping PH remains invasive measurement via right heart catheterisation [5]. Noninvasive estimation of pulmonary haemodynamics is an attractive alternative to reduce procedural risk and to more broadly study

    更新日期:2020-02-13
  • ESR/ERS statement paper on lung cancer screening
    Eur. Respir. J. (IF 11.807) Pub Date : 2020-02-01
    Hans-Ulrich Kauczor; Anne-Marie Baird; Torsten Gerriet Blum; Lorenzo Bonomo; Clementine Bostantzoglou; Otto Burghuber; Blanka Čepická; Alina Comanescu; Sébastien Couraud; Anand Devaraj; Vagn Jespersen; Sergey Morozov; Inbar Nardi Agmon; Nir Peled; Pippa Powell; Helmut Prosch; Sofia Ravara; Janette Rawlinson; Marie-Pierre Revel; Mario Silva; Annemiek Snoeckx; Bram van Ginneken; Jan P. van Meerbeeck;

    In Europe, lung cancer ranks third among the most common cancers, remaining the biggest killer. Since the publication of the first European Society of Radiology and European Respiratory Society joint white paper on lung cancer screening (LCS) in 2015, many new findings have been published and discussions have increased considerably. Thus, this updated expert opinion represents a narrative, non-systematic

    更新日期:2020-02-13
  • Noninvasive evaluation of pulmonary artery pressure during exercise: the importance of right atrial hypertension
    Eur. Respir. J. (IF 11.807) Pub Date : 2020-02-01
    Masaru Obokata; Garvan C. Kane; Hidemi Sorimachi; Yogesh N.V. Reddy; Thomas P. Olson; Alexander C. Egbe; Vojtech Melenovsky; Barry A. Borlaug

    Introduction Identification of elevated pulmonary artery pressures during exercise has important diagnostic, prognostic and therapeutic implications. Stress echocardiography is frequently used to estimate pulmonary artery pressures during exercise testing, but data supporting this practice are limited. This study examined the accuracy of Doppler echocardiography for the estimation of pulmonary artery

    更新日期:2020-02-13
  • Intensity and quality of exertional dyspnoea in patients with stable pulmonary hypertension
    Eur. Respir. J. (IF 11.807) Pub Date : 2020-02-01
    Athénaïs Boucly; Capucine Morélot-Panzini; Gilles Garcia; Jason Weatherald; Xavier Jaïs; Laurent Savale; David Montani; Marc Humbert; Thomas Similowski; Olivier Sitbon; Pierantonio Laveneziana

    Dynamic hyperinflation is observed during exercise in 60% of patients with clinically stable pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH), intensifying exertional dyspnoea. The impact of dynamic changes in respiratory mechanics during exercise on qualitative dimensions of dyspnoea in these patients has not been evaluated. 26 patients (PAH n=17; CTEPH

    更新日期:2020-02-13
  • Mendelian randomisation analysis of red cell distribution width in pulmonary arterial hypertension
    Eur. Respir. J. (IF 11.807) Pub Date : 2020-02-01
    Anna Ulrich; John Wharton; Timothy E. Thayer; Emilia M. Swietlik; Tufik R. Assad; Ankit A. Desai; Stefan Gräf; Lars Harbaum; Marc Humbert; Nicholas W. Morrell; William C. Nichols; Florent Soubrier; Laura Southgate; David-Alexandre Trégouët; Richard C. Trembath; Evan L. Brittain; Martin R. Wilkins; Inga Prokopenko; Christopher J. Rhodes

    Pulmonary arterial hypertension (PAH) is a rare disease that leads to premature death from right heart failure. It is strongly associated with elevated red cell distribution width (RDW), a correlate of several iron status biomarkers. High RDW values can signal early-stage iron deficiency or iron deficiency anaemia. This study investigated whether elevated RDW is causally associated with PAH. A two-sample

    更新日期:2020-02-13
  • Effect of asthma exacerbation during pregnancy in women with asthma: a population-based cohort study
    Eur. Respir. J. (IF 11.807) Pub Date : 2020-02-01
    Kawsari Abdullah; Jingqin Zhu; Andrea Gershon; Sharon Dell; Teresa To

    The association between asthma exacerbation during pregnancy and adverse maternal and child health outcomes have not been investigated appropriately. Our objective was to determine the short- and long-term intergenerational effect of asthma exacerbation in pregnant women with asthma. A population cohort study was conducted using data from the Ontario asthma surveillance system and population-level

    更新日期:2020-02-13
  • SABINA: global programme to evaluate prescriptions and clinical outcomes related to short-acting β2-agonist use in asthma
    Eur. Respir. J. (IF 11.807) Pub Date : 2020-02-01
    Claudia S. Cabrera; Cassandra Nan; Niklas Lindarck; Maarten J.H.I. Beekman; Sofie Arnetorp; Ralf J.P. van der Valk

    As SABA overuse is associated with exacerbations and mortality, GINA no longer recommends SABA only as a preferred reliever in asthma. A consistent pattern of high SABA use from the SABINA programme would indicate a global public health issue.

    更新日期:2020-02-13
  • Pulmonary artery enlargement and mortality risk in moderate to severe COPD: results from COPDGene
    Eur. Respir. J. (IF 11.807) Pub Date : 2020-02-01
    David C. LaFon; Surya P. Bhatt; Wassim W. Labaki; Farbod N. Rahaghi; Matthew Moll; Russ P. Bowler; Elizabeth A. Regan; Barry J. Make; James D. Crapo; Raul San Jose Estepar; Alejandro A. Diaz; Edwin K. Silverman; MeiLan K. Han; Brian Hobbs; Michael H. Cho; George R. Washko; Mark T. Dransfield; J. Michael Wells

    COPD is one of the leading causes of mortality worldwide [1]. Pulmonary hypertension has been associated with reduced survival among individuals with COPD [2] and is an independent risk factor for mortality following acute exacerbations of COPD (AECOPD) [3]. Measurement of the pulmonary artery to aorta (PA:A) ratio by computed tomography (CT) and assessment of pulmonary artery enlargement (PA:A >1)

    更新日期:2020-02-13
  • Should we worry about bedaquiline exposure in the treatment of multidrug-resistant and extensively drug-resistant tuberculosis?
    Eur. Respir. J. (IF 11.807) Pub Date : 2020-02-01
    Jan-Willem C. Alffenaar; Onno W. Akkerman; Simon Tiberi; Giovanni Sotgiu; Giovanni Battista Migliori

    Recently, the World Health Organization (WHO) released the updated guideline on the treatment for multi-drug resistant tuberculosis (MDR-TB) treatment regimens based on new experimental and observational evidence [1]. In this new guidance the most important drugs are the late-generation fluoroquinolones ( i.e. levofloxacin and moxifloxacin), linezolid and bedaquiline. Despite the new guidance, MDR-

    更新日期:2020-02-13
  • Defining “stable chronic hypercapnia” in patients with COPD: the physiological perspective
    Eur. Respir. J. (IF 11.807) Pub Date : 2020-02-01
    Caroline Hedsund; Torgny Rostrup Wilcke; Ronan M.G. Berg

    We read with interest the “European Respiratory Society guidelines on long-term home non-invasive ventilation for management of COPD” [1]. In recent years, several studies have attempted to improve outcomes by using home non-invasive ventilation in patients with end-stage COPD who suffer from chronic hypercapnic respiratory failure (CHRF). As noted in the guidelines, the definition of “stable chronic

    更新日期:2020-02-13
  • Defining “stable chronic hypercapnia” in patients with COPD: the physiological perspective
    Eur. Respir. J. (IF 11.807) Pub Date : 2020-02-01
    Begum Ergan; Raffaele Scala; Wolfram Windisch

    We would like to thank C. Hedsund and co-workers for their commentary on the “European Respiratory Society guidelines on long-term home non-invasive ventilation for management of COPD” [1]. We agree that the definition of “stable chronic hypercapnia” following exacerbation is challenging. The definition of “stable chronic hypercapnia” following COPD exacerbation is challenging

    更新日期:2020-02-13
  • Prevalence of sarcoidosis-associated pulmonary hypertension: cumulative analysis of two PULSAR studies
    Eur. Respir. J. (IF 11.807) Pub Date : 2020-02-01
    Stefan Pabst; Christian Grohé; Dirk Skowasch

    We have read with great interest the study by Huitema et al . [1] showing a pulmonary hypertension (PH) prevalence of around 3% in a large cohort of predominantly Caucasian sarcoidosis patients in a Dutch tertiary centre. According to the authors, a European Caucasian cohort has never been studied before this PULmonary hypertension in pulmonary SARcoidosis (PULSAR) study. In this context, in 2013 we

    更新日期:2020-02-13
  • Immunotherapy for nonsmall cell lung cancer: a new therapeutic algorithm
    Eur. Respir. J. (IF 11.807) Pub Date : 2020-02-01
    Thierry Berghmans; Anne-Marie Dingemans; Lizza E.L. Hendriks; Jacques Cadranel

    After a nihilistic period lasting for decades, major progress in nonsmall cell lung cancer (NSCLC) therapy were linked to the introduction of platinum-based regimens, third generation chemotherapeutic drugs and, more recently, with the discovery of oncogenic driver mutations and the development of very effective targeted therapies [1]. However, for a long time, despite known significant immune dysregulations

    更新日期:2020-02-07
  • The role of gene–environment interactions in lung disease: the urgent need for the exposome
    Eur. Respir. J. (IF 11.807) Pub Date : 2020-02-01
    Craig E. Wheelock; Stephen M. Rappaport

    Since the human genome was sequenced, extensive effort has been placed into mapping the role of genes in the onset of disease. It was expected that we would be able to explain the cause of disease and understand the genetic basis of health. However, we have found that while the genetic contribution to individual diseases varies, non-genetic factors have far greater attributable risks, often in the

    更新日期:2020-02-07
  • Training curriculum for European thoracic surgeons: a joint initiative of the European Society of Thoracic Surgeons and the European Respiratory Society
    Eur. Respir. J. (IF 11.807) Pub Date : 2020-02-01
    Gilbert Massard; Nathalie Tabin; Lars Konge; Anna Elisabeth Frick; Hasan Batirel; Alessandro Brunelli; Stefano Elia; Martin Huertgen; Laureano Molins; Kostas Papagiannopoulos; Dragan Subotic; Paul van Schil; Gonzalo Varela; Dirk van Raemdonck

    In the most recent issue of the European Journal of Cardio-Thoracic Surgery , the joint task force group on training in thoracic surgery, set up by both the European Society of Thoracic Surgeons and the European Respiratory Society (ERS), has published the core document describing the recommended training curriculum [1]. This document takes its roots from the European syllabus published in 2018 [2,

    更新日期:2020-02-07
  • Incidental venous thromboembolism, detected by chance, but still venous thromboembolism
    Eur. Respir. J. (IF 11.807) Pub Date : 2020-02-01
    Guy Meyer; Benjamin Planquette

    Incidental venous thromboembolism (VTE) refers to deep venous thrombosis or pulmonary embolism (PE) diagnosed on an imaging test, usually computed tomography, performed for another reason than the clinical suspicion of VTE. Incidental VTE is particularly frequent in patients with cancer who have an increased risk of VTE and who underwent frequent imaging tests for staging purposes and assessment of

    更新日期:2020-02-07
  • No man is an island: e-cigarette, or vaping, associated lung injury in Europe
    Eur. Respir. J. (IF 11.807) Pub Date : 2020-02-01
    Denitza P. Blagev

    An outbreak of e-cigarette, or vaping, associated lung injury (EVALI) was noted in the USA starting in March of 2019 [1]. Although there have been prior reports of various lung diseases associated with e-cigarette use since they first came on the market in 2011 [2], the outbreak this summer was remarkable in the large number of patients affected (2409 reported hospitalised with 52 deaths as of 13 December

    更新日期:2020-02-07
  • ERS/TSANZ Task Force Statement on the management of reproduction and pregnancy in women with airways diseases
    Eur. Respir. J. (IF 11.807) Pub Date : 2020-02-01
    Peter G. Middleton; Elisabeth J. Gade; Cristina Aguilera; Lucy MacKillop; Brenda M. Button; Courtney Coleman; Barbara Johnson; Charlotte Albrechtsen; Frank Edenborough; David Rigau; Peter G. Gibson; Vibeke Backer

    This European Respiratory Society/Thoracic Society of Australia and New Zealand statement outlines a review of the literature and expert opinion concerning the management of reproduction and pregnancy in women with airways diseases: asthma, cystic fibrosis (CF) and non-CF bronchiectasis. Many women with these diseases are now living into reproductive age, with some developing moderate-to-severe impairment

    更新日期:2020-02-07
  • Clinical implications of incidental venous thromboembolism in cancer patients
    Eur. Respir. J. (IF 11.807) Pub Date : 2020-02-01
    Frits I. Mulder; Marcello Di Nisio; Cihan Ay; Marc Carrier; Floris T.M. Bosch; Annelise Segers; Noémie Kraaijpoel; Michael A. Grosso; George Zhang; Peter Verhamme; Tzu-Fei Wang; Jeffrey I. Weitz; Saskia Middeldorp; Gary Raskob; Ludo F.M. Beenen; Harry R. Büller; Nick van Es

    Introduction In cancer patients, current guidance suggests similar treatment for incidental and symptomatic venous thromboembolism (VTE), mainly based on retrospective data. We aimed to evaluate anticoagulant therapy in cancer patients with incidental and symptomatic VTE. Methods The Hokusai VTE Cancer Study was a randomised controlled trial comparing edoxaban with dalteparin for cancer-associated

    更新日期:2020-02-07
  • Differential DNA methylation in bronchial biopsies between persistent asthma and asthma in remission
    Eur. Respir. J. (IF 11.807) Pub Date : 2020-02-01
    Cornelis J. Vermeulen; Cheng-Jian Xu; Judith M. Vonk; Nick H.T. ten Hacken; Wim Timens; Irene H. Heijink; Martijn C. Nawijn; Jeunard Boekhoudt; Antoon J. van Oosterhout; Karen Affleck; Markus Weckmann; Gerard H. Koppelman; Maarten van den Berge

    Approximately 40% of asthmatics experience remission of asthma symptoms. A better understanding of biological pathways leading to asthma remission may provide insight into new therapeutic targets for asthma. As an important mechanism of gene regulation, investigation of DNA methylation provides a promising approach. Our objective was to identify differences in epigenome wide DNA methylation levels

    更新日期:2020-02-07
  • Relationship of obstructive sleep apnoea severity and subclinical systemic atherosclerosis
    Eur. Respir. J. (IF 11.807) Pub Date : 2020-02-01
    Soriul Kim; Ki Yeol Lee; Nan Hee Kim; Robert D. Abbott; Cherry Kim; Seung Ku Lee; Seong Hwan Kim; Chol Shin

    Obstructive sleep apnoea (OSA) is a common form of sleep disordered breathing. Untreated OSA might accelerate atherosclerosis, potentially increasing the cardiovascular disease burden in patients. The present study aimed to evaluate the association between objectively measured OSA severity and the presence of subclinical systemic atherosclerosis using noninvasive measurements, including tomographic

    更新日期:2020-02-07
  • Genomic characterisation of pulmonary subsolid nodules: mutational landscape and radiological features
    Eur. Respir. J. (IF 11.807) Pub Date : 2020-02-01
    Yanmeng Li; Xiao Li; Hao Li; Yifan Zhao; Ziyang Liu; Kunkun Sun; Xiang Zhu; Qingyi Qi; Bei An; Danhua Shen; Ruoyan Li; Taorui Liu; Jiahui Mi; Lientu Wang; Fan Yang; Fan Bai; Jun Wang

    Background Lung adenocarcinomas (LUADs) that display radiologically as subsolid nodules (SSNs) exhibit more indolent biological behaviour than solid LUADs. SSNs, commonly encompassing pre-invasive and invasive yet early-stage adenocarcinomas, can be categorised as pure ground-glass nodules and part-solid nodules. The genomic characteristics of SSNs remain poorly understood. Methods We subjected 154

    更新日期:2020-02-07
  • Pulmonary xenon-129 MRI: new opportunities to unravel enigmas in respiratory medicine
    Eur. Respir. J. (IF 11.807) Pub Date : 2020-02-01
    Rachel L. Eddy; Grace Parraga

    129Xe MRI provides rapid, sensitive, non-invasive, high spatial resolution and simultaneous measurements of pulmonary ventilation, tissue microstructure and gas exchange, and is poised for routine clinical assessments in patients with chronic lung disease

    更新日期:2020-02-07
  • An imported case of e-cigarette or vaping associated lung injury in Barcelona
    Eur. Respir. J. (IF 11.807) Pub Date : 2020-02-01
    Gherzon Simón Casanova; Rosanel Amaro; Néstor Soler; Marcelo Sánchez; Joan Ramón Badía; Joan Albert Barberà; Alvar Agustí

    Very recently, Layden et al. [1] published the first series of 53 patients with acute lung injury associated with the use of e-cigarettes (also known as vaping) in Wisconsin and Illinois, USA. To our knowledge, only a few cases of e-cigarette, or vaping, associated lung injury (EVALI) have been reported outside the USA (in Canada and Japan) and, so far, none in Europe [2]. Here we present the case

    更新日期:2020-02-07
  • Cost-effectiveness of ambulatory oxygen in improving quality of life in fibrotic lung disease: preliminary evidence from the AmbOx Trial
    Eur. Respir. J. (IF 11.807) Pub Date : 2020-02-01
    Jennifer A. Whitty; Jenny Rankin; Dina Visca; Vicky Tsipouri; Letizia Mori; Lisa Spencer; Huzaifa Adamali; Toby M. Maher; Nicholas S. Hopkinson; Surinder S. Birring; Morag Farquhar; Athol U. Wells; Piersante Sestini; Elisabetta A. Renzoni

    Fibrotic interstitial lung diseases (ILDs) are chronic and often progressive conditions resulting in substantial impact on morbidity, health-related quality of life (HRQoL), and health system costs. Ambulatory oxygen (AO) used during routine daily activities could lead to improved exercise performance, reduced symptoms and improved mobility in daily life. A UK prospective, multicentre, mixed method

    更新日期:2020-02-07
  • Longitudinal changes in airway hyperresponsiveness and COPD mortality
    Eur. Respir. J. (IF 11.807) Pub Date : 2020-02-01
    Andreas A. Teferra; Judith M. Vonk; H. Marike Boezen

    Airway hyperresponsiveness (AHR) is associated with an increased mortality risk among males [1] and chronic obstructive pulmonary disease (COPD) patients [2]. However, this association is largely based on cross-sectional studies using a single measurement of AHR to predict mortality; inherently ignoring the longitudinal variability of AHR. AHR is variable regardless of disease or medication status,

    更新日期:2020-02-07
  • Diagnostic sensitivity of SILVAMP TB-LAM (FujiLAM) point-of-care urine assay for extra-pulmonary tuberculosis in people living with HIV
    Eur. Respir. J. (IF 11.807) Pub Date : 2020-02-01
    Andrew D. Kerkhoff; Bianca Sossen; Charlotte Schutz; Elena Ivanova Reipold; Andre Trollip; Emmanuel Moreau; Samuel G. Schumacher; Rosie Burton; Amy Ward; Mark P. Nicol; Graeme Meintjes; Claudia M. Denkinger; Tobias Broger

    Diagnosing tuberculosis (TB) in people living with HIV (PLHIV) remains challenging in part, because of its diversity of clinical manifestations, including high rates of extra-pulmonary and disseminated disease [1]. In particular, disseminated TB, involving multiple organ systems, is associated with high mortality but often presents non-specifically, which may hinder prompt diagnosis [2, 3]. Xpert MTB

    更新日期:2020-02-07
  • “Truth is ever to be found in simplicity, and not in the multiplicity and confusion of things” — Sir Isaac Newton
    Eur. Respir. J. (IF 11.807) Pub Date : 2020-02-01
    Jaclyn A. Smith; Mike A. Wortley; Sara Bonvini; Mark Birrell; Maria G. Belvisi

    We read with interest the recent publication by Morice et al. [1] “The effect of gefapixant, a P2X3 antagonist, on cough reflex sensitivity: a randomised placebo-controlled study” and the accompanying editorial by Turner and Birring [2] “Chronic cough: ATP, afferent pathways and hypersensitivity”. The authors of both publications conclude the results are suggestive of two separate neuronal pathways

    更新日期:2020-02-07
  • Author response: The human cough reflex has separate, distinct pathways
    Eur. Respir. J. (IF 11.807) Pub Date : 2020-02-01
    Alyn H. Morice; Michael M. Kitt; Anthony P. Ford; Andrew M. Tershakovec; Wen-Chi Wu; Kayleigh Brindle; Rachel Thompson; Susannah Thackray-Nocera; Caroline Wright

    We thank J.A. Smith and co-workers for their interest in our paper [1]. Perhaps an even more ancient truth, that of William of Occam [2], should be applied to this discussion. The human cough reflex has separate, distinct pathways

    更新日期:2020-02-07
  • GINA recommendations in adults with symptomatic mild asthma and a smoking history
    Eur. Respir. J. (IF 11.807) Pub Date : 2020-02-01
    Neil C. Thomson; Rekha Chaudhuri

    The Global Initiative for Asthma (GINA) 2019 report makes a major change in asthma management by recommending that adults and adolescents with mild symptomatic asthma (Step 1) receive as-needed low-dose inhaled corticosteroid (ICS)–formoterol rather than a short-acting β2-agonist alone [1]. At step 2, daily low-dose ICS is recommended, and GINA 2019 considers low-dose ICS–formoterol reliever as an

    更新日期:2020-02-07
  • GINA recommendations in adults with symptomatic mild asthma and a smoking history
    Eur. Respir. J. (IF 11.807) Pub Date : 2020-02-01
    Helen K. Reddel

    N.C. Thomson and R. Chaudhuri raise an important issue about treatment recommendations for patients with asthma who have a significant smoking history. The exclusion of such patients from most asthma studies appears to have largely been driven by the requirement by regulators for pure “asthma” and “COPD” populations in pharmacotherapy studies that are designed for obtaining regulatory approval. However

    更新日期:2020-02-07
  • Electrical stimulation in obstructive sleep apnoea: the less invasive the better?
    Eur. Respir. J. (IF 11.807) Pub Date : 2020-02-01
    Martino Pengo; Esther Irene Schwarz; Joerg Steier

    We read with interest the article by Eastwood et al. [1] on bilateral hypoglossal nerve stimulation for treatment of adult obstructive sleep apnoea (OSA), the BLAST OSA trial. The authors present data on a novel approach, the Genio system, to stimulate the hypoglossal nerve and provide neuromuscular tone to the genioglossus, the main dilator muscle of the upper airway, to improve upper airway patency

    更新日期:2020-02-07
  • January Podcast: ERS guidelines on chronic cough
    Eur. Respir. J. (IF 11.807) Pub Date : 2020-01-01
    European Respiratory Society

    As part of the January issue, the European Respiratory Journal presents the latest in its series of podcasts. Deputy Chief Editor James Chalmers interviews Alyn Morice (University of Hull, Hull, UK) about the European Respiratory Society’s new guidelines on the diagnosis and treatment of chronic cough in adults and children published in this issue.

    更新日期:2020-01-31
  • Airway mucus accumulation in COPD: the cholinergic paradox!
    Eur. Respir. J. (IF 11.807) Pub Date : 2020-01-01
    Pierre-Régis Burgel

    Mucus accumulation, related to excess mucus production and secretion in proximal and distal airways, is an established characteristic in the airways of patients with COPD. Chronic bronchitis, a consequence of cigarette smoking that can be found in smokers with or without COPD, is a disabling symptom and has been associated with increased rates of exacerbations and hospitalisations in patients with

    更新日期:2020-01-31
  • Excess mucus viscosity and airway dehydration impact COPD airway clearance
    Eur. Respir. J. (IF 11.807) Pub Date : 2020-01-01
    Vivian Y. Lin; Niroop Kaza; Susan E. Birket; Harrison Kim; Lloyd J. Edwards; Jennifer LaFontaine; Linbo Liu; Marina Mazur; Stephen A. Byzek; Justin Hanes; Guillermo J. Tearney; S. Vamsee Raju; Steven M. Rowe

    The mechanisms by which cigarette smoking impairs airway mucus clearance are not well understood. We recently established a ferret model of cigarette smoke-induced chronic obstructive pulmonary disease (COPD) exhibiting chronic bronchitis. We investigated the effects of cigarette smoke on mucociliary transport (MCT). Adult ferrets were exposed to cigarette smoke for 6 months, with in vivo mucociliary

    更新日期:2020-01-31
  • Uncovering the mechanisms of exertional dyspnoea in combined pulmonary fibrosis and emphysema
    Eur. Respir. J. (IF 11.807) Pub Date : 2020-01-01
    Camila M. Costa; J. Alberto Neder; Carlos G. Verrastro; Marcelle Paula-Ribeiro; Roberta Ramos; Eloara M. Ferreira; Luiz E. Nery; Denis E. O'Donnell; Carlos A.C. Pereira; Jaquelina Ota-Arakaki

    The prevailing view is that exertional dyspnoea in patients with combined idiopathic pulmonary fibrosis (IPF) and emphysema (CPFE) can be largely explained by severe hypoxaemia. However, there is little evidence to support these assumptions. We prospectively contrasted the sensory and physiological responses to exercise in 42 CPFE and 16 IPF patients matched by the severity of exertional hypoxaemia

    更新日期:2020-01-31
  • Circulating plasma exosomes in obstructive sleep apnoea and reverse dipping blood pressure
    Eur. Respir. J. (IF 11.807) Pub Date : 2020-01-01
    Abdelnaby Khalyfa; David Gozal; Wen-Ching Chan; Jorge Andrade; Bharati Prasad

    Background Obstructive sleep apnoea (OSA) increases the risk of an abnormal nondipping 24 h blood pressure profile, an independent risk factor for cardiovascular disease (CVD). We examined differential exosomal microRNA (miRNA) expression in untreated OSA patients with normal dipping blood pressure (NDBP) and reverse dipping blood pressure (RDBP), an extreme form of nondipping, to understand the mechanisms

    更新日期:2020-01-31
  • Validation of short- and long-term demographic forecasts using the Canadian Cystic Fibrosis Registry
    Eur. Respir. J. (IF 11.807) Pub Date : 2020-01-01
    Vanessa Martelli; Jenna Sykes; Pierre-Régis Burgel; Gil Bellis; Adèle Coriati; Sanja Stanojevic; Anne Louise Stephenson

    National cystic fibrosis (CF) data registries track patient characteristics over time and have provided insight into both emerging trends and current clinical needs. In a recent study, Burgel et al . [1] utilised the flow method, a demographic model that predicts future trends in populations, and forecasted a 50% increase in the Western European CF population by 2025, with the adult population experiencing

    更新日期:2020-01-31
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