Objectives Virtual-assisted lung mapping (VAL-MAP) 2.0 is a novel preoperative bronchoscopic lung mapping technique combining the multiple dye marks of conventional VAL-MAP with intrabronchial microcoils to navigate thoracoscopic deep lung resection. This study’s purpose was to evaluate the feasibility of VAL-MAP 2.0 in resecting deeply-located pulmonary nodules with adequate margins. Methods A multicenter

Objectives The Canadian Mitral Research Alliance CardioLink-2 study investigated leaflet resection versus preservation techniques for posterior leaflet prolapse and found no difference in their effect on mean mitral gradient at peak exercise 12-months postoperatively. The purpose of this sub-analysis is to evaluate the impact of the two strategies on left ventricular (LV) reverse remodeling after repair

Objective This pilot study sought to evaluate the feasibility of our donation after circulatory death (DCD) heart transplant protocol using cardiopulmonary bypass (CPB) for normothermic regional reperfusion (NRP). Methods Suitable local DCD candidates were transferred to our institution. Life support was withdrawn in the operating room (OR). Upon declaration of circulatory death, sternotomy was performed

Objectives We examined for differences in pre-left ventricular assist device (LVAD) myocardial transcriptome between patients with different degrees of MR. Methods From 1/2018 to 10/2019, we collected left ventricular cores during durable LVAD implantation (n=72). Retrospective chart review was performed. Total RNA was isolated from LV cores and used for the construction of cDNA sequence libraries

Objective To investigate the association of preoperative renal dysfunction and long-term outcome following lung cancer surgery. Methods Using the Japanese Lung Cancer Registry data, we retrospectively examined 16,377 patients who underwent surgery for non-small cell lung cancer in 2010. Patients’ renal function status was categorized as follows: serum creatinine < 1.5 mg/dL (control, n = 16,169), serum

Objective The ideal management of peripheral pulmonary artery stenosis is still controversial. We adopted a primary surgical approach to this complex lesion with excellent early outcomes. In this study, we analyzed our late outcomes. Methods We performed a retrospective review of 91 biventricular patients who underwent peripheral pulmonary artery reconstruction from March 2008 to July 2020. Our surgical

Background Endoscopic submucosal dissection (ESD) has become the standard treatment for superficial esophageal squamous cell neoplasia (SESCN), however local recurrence still occasionally occurs even if the patients meet the current curative criteria. Esophageal ducts of the submucosal gland may serve as a pathway for the spread of SESCN to a deeper layer. However, the clinical impact of ductal involvement

Objective To compare midterm outcomes of aortic valve-replacing root replacement (AVR) and aortic valve-sparing root replacement (AVS) in patients with Marfan syndrome. Methods Patients who met strict Ghent diagnostic criteria for Marfan syndrome and who underwent either AVR or AVS between March 1, 2005 and December 31, 2010 were enrolled in a 3-year follow-up prospective, multicenter, international

Objectives The treatment of mitral valve disease in the presence of mitral annular calcification (MAC) is associated with an increased risk of cardiovascular and all-cause mortality. Various surgical and transcatheter techniques for the treatment of mitral disease with severe MAC have been described. However, these procedures are associated with high risk of operative morbidity and mortality. We describe

Background Comparative data after percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) for unprotected left main coronary artery (ULMCA) disease according to lesion site (ostial/shaft vs distal) are scant. The aim of this metanalysis was to investigate outcomes after PCI or CABG for ULMCA disease according to lesion site. Methods Randomized controlled trials (RCTs) and

Objective We studied a cohort of nonsyndromic cAVSD patients with and without concomitant complex cardiac anatomy and compared the outcomes following surgical repair. Methods Between 1993 and 2018, 62 nonsyndromic patients underwent cAVSD repair. Sixteen patients (26%) were complex cAVSD having variables representing concomitant cardiac anatomic complexity (TOF, DORV, TAPVR, concomitant aortic arch

Objective Development of novel scoring system that would be predictive of postoperative pulmonary complications in critically ill patients after cardiac and major vascular surgery. Methods 17,433 postoperative patients after coronary artery bypass graft, valve or thoracic aorta repair surgery admitted to the cardiovascular intensive care units (ICU) at Cleveland Clinic Main Campus from 2009-2015. Primary

Objectives Neonatal rodents and piglets naturally regenerate the injured heart after myocardial infarction (MI). We hypothesized that neonatal rabbits also exhibit natural heart regeneration after MI. Methods New Zealand white rabbit kits underwent sham surgery or left coronary ligation on postnatal day 1 (P1, n=94), postnatal day 4 (P4, n=11), or postnatal day 7 (P7, n=52). Hearts were explanted 1

Objective Calcified aortic valvular disease (CAVD) is known as an inflammation-related process and is also related to force. The purpose of this study was to determine whether micromechanical force could induce valve calcification of porcine valvular interstitial cells (pVICs) and further examine the role of integrin αvβ3 in valvular calcification by using a novel method – magnetic twisting cytometry

This International evidence-based nomenclature and classification consensus on the congenital bicuspid aortic valve and its aortopathy recognizes 3 types of bicuspid aortic valve: 1. Fused type, with 3 phenotypes: right-left cusp fusion, right-non cusp fusion and left-non cusp fusion; 2. 2-sinus type with 2 phenotypes: Latero-lateral and antero-posterior; and 3. Partial-fusion or forme fruste. This

This International Consensus Classification and Nomenclature for the congenital bicuspid aortic valve condition recognizes 3 types of bicuspid valves: 1. The fused type (right-left cusp fusion, right-non-coronary cusp fusion and left-non-coronary cusp fusion phenotypes); 2. The 2-sinus type (latero-lateral and antero-posterior phenotypes); and 3. The partial-fusion (forme fruste) type. The presence