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Prevalence of Impurity Retention Mechanisms in Pharmaceutical Crystallizations Org. Process Res. Dev. (IF 3.858) Pub Date : 2023-03-24 Fredrik L. Nordstrom, Eric Sirota, Clara Hartmanshenn, Thomas T. Kwok, Mitchell Paolello, Huayu Li, Vincent Abeyta, Tommasina Bramante, Emma Madrigal, Taylor Behre, Gerard Capellades
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Photocatalytic and Photoinduced Phosphonylation of Aryl Iodides: A Batch and Flow Study Org. Process Res. Dev. (IF 3.858) Pub Date : 2023-03-24 Romain Lapierre, Thi Minh Thi Le, Bruno Schiavi, Damien Thevenet, Marc Bazin, Ryan Buzdygon, Philippe Jubault, Thomas Poisson
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Case Studies in the Application of a Workflow-Based Crystallization Design for Optimized Impurity Rejection in Pharmaceutical Development Org. Process Res. Dev. (IF 3.858) Pub Date : 2023-03-24 Paridhi Agrawal, Saurin H. Rawal, Venkata Ramana Reddy, Shekhar K. Viswanath, Jeremy M. Merritt
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Alternative Approach to the Large-Scale Synthesis of the Densely Functionalized Pyrrolidone BMT-415200 Org. Process Res. Dev. (IF 3.858) Pub Date : 2023-03-22 Souvik Rakshit, Shunmugaraj Sathasivam, Raghurami Reddy, Saladi V. Rao, Vijaykumar Shekarappa, Moorthy Kandasamy, Mohamed Jaleel, Saravanan Murugan, Anuradha Bhat, Tamilarasan Subramani, Thirumalai Lakshminarasimhan, Aravind Gangu, Steven R. Wisniewski, Nathaniel Kopp, Ian Hale, Jason M. Stevens, Victor W. Rosso, Martin D. Eastgate, Rajappa Vaidyanathan
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Integrating Process Development and Safety Analysis for Scale-Up of a Diborane-Generating Reduction Reaction Org. Process Res. Dev. (IF 3.858) Pub Date : 2023-03-21 Brittany M. Armstrong, Taylor Behre, Ben W. H. Turnbull, Daniel Bishara, Clara Hartmanshenn, Erin McCarthy, Michael Whittington, Yining Ji, Anna Jenks, Richard Desmond, Daniel J. Muzzio, James Corry, Ralph Zhao, Nadine Kuhl, Cheol K. Chung
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Collaboration as a Key to Advance Capabilities for Earth-Abundant Metal Catalysis Org. Process Res. Dev. (IF 3.858) Pub Date : 2023-03-20 Paul J. Chirik, Keary M. Engle, Eric M. Simmons, Steven R. Wisniewski
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Spherical Agglomeration of Safinamide Mesylate: A Case Study of a Simultaneous Control of Crystalline Landscape and Micromeritic Properties Org. Process Res. Dev. (IF 3.858) Pub Date : 2023-03-17 Aurélien Lemercier, Yohann Cartigny, Pierrick Morice, Elise Vanbiervliet, Massimiliano Forcato, Gérard Coquerel
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Rapid Enantiomeric Excess Measurements of Enantioisotopomers by Molecular Rotational Resonance Spectroscopy Org. Process Res. Dev. (IF 3.858) Pub Date : 2023-03-17 Reilly E. Sonstrom, Zoua Pa Vang, Haley N. Scolati, Justin L. Neill, Brooks H. Pate, Joseph R. Clark
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Biocatalytic Asymmetric Reduction of a Sterically Hindered α-Bromo Ketone for the Synthesis of Key Intermediates of Olodaterol Org. Process Res. Dev. (IF 3.858) Pub Date : 2023-03-15 Yahui Feng, Zihong Zhou, Shuming Wu, Wei Lin, Songquan Lu, Xiaolei Pang, Ke Xia, Fang He, Qin Zhang, Hu Yang, Zhongqing Wang
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Scalable Palladium-Catalyzed C(sp3)–H Carbonylation of Alkylamines in Batch and Continuous Flow Org. Process Res. Dev. (IF 3.858) Pub Date : 2023-03-15 Jacek Zakrzewski, Polina Yaseneva, Connor J. Taylor, Matthew J. Gaunt, Alexei A. Lapkin
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Determining Phase Separation Dynamics with an Automated Image Processing Algorithm Org. Process Res. Dev. (IF 3.858) Pub Date : 2023-03-14 James Daglish, A. John Blacker, Gregory de Boer, Alex Crampton, David R. J. Hose, Anna R. Parsons, Nikil Kapur
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Establishing Best Practice for the Application and Support of Solubility Purge Factors Org. Process Res. Dev. (IF 3.858) Pub Date : 2023-03-14 Michael J. Burns, Ian X. Andrews, Jens-Christoph Baumann, Eric L. Elliott, Jared W. Fennell, Jeffrey M. Kallemeyn, Sebastien Lemaire, Natasha S. Murphy, Magali Palacio, Steven A. Raw, Alastair J. Roberts, Nayrton Flávio Moura Rocha, Didier Schils, Rolf Schulte Oestrich, Andrew L. Shannon-Little, Neil Stevenson, Pere Talavera, Andrew Teasdale, Michael W. Urquhart, Fernanda Waechter
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Drawing a Line: Where Might the Cohort of Concern End? Org. Process Res. Dev. (IF 3.858) Pub Date : 2023-03-14 David J. Ponting, Robert S. Foster
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Leveraging Synergistic Solubility in the Development of a Direct Isolation Process for Nemtabrutinib Org. Process Res. Dev. (IF 3.858) Pub Date : 2023-03-09 Yonggang Chen, Luca Iuzzolino, Samantha A. Burgess, Cheol K. Chung, James Corry, Morgan Crawford, Richard Desmond, Erik Guetschow, Clara Hartmanshenn, Nadine Kuhl, Zhu Liu, Hanlin Luo, Alison C. McQuilken, Justin A. Newman, Hong Ren, David A. Thaisrivongs, Zhixun Wang, Eric Sirota
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Exploiting the Physical Properties of Diethanolamine Boronic Esters for Process Improvements in AZD5718 Org. Process Res. Dev. (IF 3.858) Pub Date : 2023-03-09 Jean-Marc Henry, David Milne, Dave Perkins, William Hicks, David R. J. Hose, Andrew D. Campbell, Alexander K. Mullen, Phillip A. Inglesby, Steven A. Raw, Martin F. Jones
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Development of a Kilogram-Scale Synthesis of a Key Ulevostinag Subunit Part II: An Electrophilic Approach to Fluorinated Nucleosides Org. Process Res. Dev. (IF 3.858) Pub Date : 2023-03-07 Andrew J. Neel, Zhuqing Liu, Tamas Benkovics, Lu Wang, Stephan M. Rummelt, Heather C. Johnson, Kevin M. Belyk, Feng Xu, Cheol K. Chung, David J. Lamberto, Ryan D. Cohen, Stephanus Axnanda, Zachary E. X. Dance
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Development of a Kilogram-Scale Synthesis of a Key Ulevostinag Subunit Part I: Accessing a Keto-Nucleoside Intermediate from Guanosine Org. Process Res. Dev. (IF 3.858) Pub Date : 2023-03-07 Ben W. H. Turnbull, Feng Peng, Andrew J. Neel, Tamas Benkovics, Zhuqing Liu, Cheol K. Chung, Zhiguo Jake Song, Lushi Tan, Khateeta M. Emerson, Chengqian Xiao, Yi Zhang, Benjamin D. Sherry
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Some Items of Interest to Process R&D Chemists and Engineers Org. Process Res. Dev. (IF 3.858) Pub Date : 2023-03-07 Alan Steven, Carlos Mateos, Andrei A. Zlota, Christopher C. Nawrat, Alexandre Barthelme, Sylvain Guizzetti, Rik Oost, Paul F. Richardson, Robert B. Kargbo, John Knight
This article has not yet been cited by other publications.
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Method to Rapidly Identify Potential Solvent Systems for Crystallization of Cocrystals Org. Process Res. Dev. (IF 3.858) Pub Date : 2023-03-06 Lorenzo Codan, Laura Daza, Eric Sirota
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Modeling and Optimization of a Suspension Crystallization Separation Process for para-Xylene Purification Org. Process Res. Dev. (IF 3.858) Pub Date : 2023-03-06 Zhenxing Cai, Gengfei Yang, Hui Zhao, Xiaobo Chen, Chaohe Yang
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Process Development and Scale-Up of the Novel β-Lactamase Inhibitor WCK 6395 Org. Process Res. Dev. (IF 3.858) Pub Date : 2023-03-03 Yasinalli Tamboli, Jaydeo T. Kilbile, Vikas Deshmukh, Vipul Rane, Ravikumar Tadiparthi, Ravindra Yeole, Arvind Y. Merwade
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Development of a Scalable Asymmetric Process for the Synthesis of GLYT1 Inhibitor BI 425809 (Iclepertin) Org. Process Res. Dev. (IF 3.858) Pub Date : 2023-03-03 Rogelio Frutos, Thomas G. Tampone, Jason Mulder, Joe Gao, Joshua D. Sieber, Sonia Rodriguez, Nizar Haddad, Katrin Baer, Jack Brown, Bing-Shiou Yang, Riccardo Giovannini, Jinhua J. Song, Nelu Grinberg, Heewon Lee, Chris H. Senanayake
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Regulatory Highlights Org. Process Res. Dev. (IF 3.858) Pub Date : 2023-03-03 Andrew Teasdale, Kevin Hughes
This article has not yet been cited by other publications.
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A Convergent Synthesis of HPK1 Inhibitor GNE-6893 via Palladium-Catalyzed Functionalization of a Tetrasubstituted Isoquinoline Org. Process Res. Dev. (IF 3.858) Pub Date : 2023-02-27 Andreas Stumpf, Di Xu, Rohit Ranjan, Remy Angelaud, Francis Gosselin
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Scale-Up Synthesis of 1-Methyladamantane and Its Functionalization as a Key Point for Promising Antiviral Agents Org. Process Res. Dev. (IF 3.858) Pub Date : 2023-02-24 Alexander E. Pashenko, Alexandr Gaidai, Nazar Hryhoriev, Olesia Volovenko, Igor Levandovskiy, Olga Maksymenko, Dmitriy M. Volochnyuk, Sergey V. Ryabukhin
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Route Optimization of the Non-covalent Modulator of Hemoglobin PF-07059013 for the Treatment of Sickle Cell Disease, Part I: From Discovery Synthesis to First Kilogram-Scale Manufacture Org. Process Res. Dev. (IF 3.858) Pub Date : 2023-02-22 Aaron Baldwin, Shawn Cabral, Kris N. Jones, Jeffrey T. Kohrt, Chris Limberakis, Yiyang Liu, Javier Magano, Sebastien Monfette, Asaad Nematalla, Sami Ovaska, David W. Piotrowski, Jared L. Piper, Jeffrey W. Raggon, Benjamin A. Thuma, Liuqing Wei
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Visible-Light Photocatalysis Academic–Industrial Collaboration Retrospective: Shared Learning and Impact Analysis Org. Process Res. Dev. (IF 3.858) Pub Date : 2023-02-21 Kevin P. Cole, James J. Douglas, Travis Hammerstad, Corey R. J. Stephenson
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Recent Advances in Nonprecious Metal Catalysis Org. Process Res. Dev. (IF 3.858) Pub Date : 2023-02-17 Michael C. Haibach, Shashank Shekhar, Tonia S. Ahmed, Andrew R. Ickes
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Development of Adagrasib’s Commercial Manufacturing Route Org. Process Res. Dev. (IF 3.858) Pub Date : 2023-02-17 David R. Snead, Yonghong Gan, Thomas Scattolin, Dinesh J. Paymode, Michal Achmatowicz, Duane E. Rudisill, Ephraim S. Vidal, Tawfik Gharbaoui, Phil Roberts, Jianbo Yang, Zhangbing Shi, Wei Liu, Joshua Bolger, Zhen Qiao, Cheng-yi Chen
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Gram-Scale Synthesis of Sulfoxides via Oxygen Enabled by Fe(NO3)3·9H2O Org. Process Res. Dev. (IF 3.858) Pub Date : 2023-02-12 Kai Liu, Jiaolong Meng, Xuefeng Jiang
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Opportunities and Challenges in Mechanochemical Cocrystallization toward Scaled-Up Pharmaceutical Manufacturing Org. Process Res. Dev. (IF 3.858) Pub Date : 2023-02-13 Sithmi Nimashi Madanayake, Aruna Manipura, Ranjit Thakuria, Nadeesh M. Adassooriya
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Simultaneous Characterization of Reaction Kinetics and Enthalpy by Calorimetry Based on Spatially Resolved Temperature Profile in Flow Reactors Org. Process Res. Dev. (IF 3.858) Pub Date : 2023-02-10 Yusuke Imamura, Jun-ichi Ogawa, Yuma Otake, Hidenosuke Itoh
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Formation of Dialkyl-N-nitrosamines in Aqueous Solution: An Experimental Validation of a Conservative Predictive Model and a Comparison of the Rates of Dialkyl and Trialkylamine Nitrosation Org. Process Res. Dev. (IF 3.858) Pub Date : 2023-02-08 Ian W. Ashworth, Debasis Dey, Olivier Dirat, Paul McDaid, Daniel Lee, Justin Moser, Kausik K. Nanda
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Optimization and Scale-Up of a Continuous Flow Synthesis of Dapagliflozin Org. Process Res. Dev. (IF 3.858) Pub Date : 2023-02-08 Chunchao Wang, Boxin Xuan, Cheng Huang, Jingchun Yao, Chengjun Wu, Tiemin Sun
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Gefapixant Citrate (MK-7264) Sulfonamide Step Speciation Study: Investigation into Precipitation–Dissolution Events during Addition of Chlorosulfonic Acid Org. Process Res. Dev. (IF 3.858) Pub Date : 2023-02-08 Nelo R. Rivera, Ryan D. Cohen, Si-Wei Zhang, Zachary E. X. Dance, Holst M. Halsey, Siqing Song, Xiaodong Bu, Mikhail Reibarkh, Hong Ren, Alfred Y. Lee, Darryl Chang, Sachin Lohani
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Characterization of a Modular Microfluidic Section for Seeded Nucleation in Multiphase Flow Org. Process Res. Dev. (IF 3.858) Pub Date : 2023-02-08 Cedric Devos, Elena Brozzi, Tom Van Gerven, Simon Kuhn
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Strategies for the Production of [11C]LY2795050 for Clinical Use Org. Process Res. Dev. (IF 3.858) Pub Date : 2023-02-08 Tanpreet Kaur, Xia Shao, Mami Horikawa, Liam S. Sharninghausen, Sean Preshlock, Allen F. Brooks, Bradford D. Henderson, Robert A. Koeppe, Alexandre F. DaSilva, Melanie S. Sanford, Peter J. H. Scott
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Some Items of Interest to Process R&D Chemists and Engineers Org. Process Res. Dev. (IF 3.858) Pub Date : 2023-02-07 James A. Schwindeman, David S. B. Daniels, James J. Douglas, Alex Kosanovich, Wenyi Zhao, Christopher B. Kelly, Timothy Kwok, John Knight
This article has not yet been cited by other publications.
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Gram-Scale Synthesis of the C14–C23 Fragment of Eribulin Org. Process Res. Dev. (IF 3.858) Pub Date : 2023-02-06 Qiuhan Yu, Yueer Zhou, Xinai Gao, Shuheng Pan, Feng Lin, Wei Li
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Early Clinical Development of Lufotrelvir as a Potential Therapy for COVID-19 Org. Process Res. Dev. (IF 3.858) Pub Date : 2023-02-03 Christophe Allais, David Bernhardson, Adam R. Brown, Gary M. Chinigo, Jean-Nicolas Desrosiers, Kenneth J. DiRico, Ian Hotham, Brian P. Jones, Samir A. Kulkarni, Chad A. Lewis, Ricardo Lira, Richard P. Loach, Peter D. Morse, James J. Mousseau, Matthew A. Perry, Zhihui Peng, David W. Place, Anil M. Rane, Lacey Samp, Robert A. Singer, Zheng Wang, Gerald A. Weisenburger, Hatice G. Yayla, Joseph M. Zanghi
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Safety Considerations and Proposed Workflow for Laboratory-Scale Chemical Synthesis by Ball Milling Org. Process Res. Dev. (IF 3.858) Pub Date : 2023-02-03 Ian Priestley, Claudio Battilocchio, Andrei V. Iosub, Fabien Barreteau, Gavin W. Bluck, Kenneth B. Ling, Katharine Ingram, Maria Ciaccia, Jamie A. Leitch, Duncan L. Browne
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Continuous-Flow Supercritical CO2 Platform for In-Situ Synthesis and Purification of Small Molecules for Drug Discovery Org. Process Res. Dev. (IF 3.858) Pub Date : 2023-02-03 Sergio Alcalde, Raúl Porcar, María Luz De La Puente, Graham R. Cumming, Carlos Mateos, Pablo García-Losada, Cristina Anta, Juan A. Rincón, Eduardo García-Verdugo
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In Support of Early-Career Researchers Org. Process Res. Dev. (IF 3.858) Pub Date : 2023-02-02 Rakeshwar Bandichhor, A. S. Borovik, Ana de Bettencourt-Dias, Martin D. Eastgate, Nora S. Radu, Feng Shi, Lisa McElwee-White
The Supporting Information is available free of charge at https://pubs.acs.org/doi/10.1021/acs.oprd.3c00017. Table of selected early-career researchers in organic and inorganic chemistry (PDF) Most electronic Supporting Information files are available without a subscription to ACS Web Editions. Such files may be downloaded by article for research use (if there is a public use license linked to the
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Continuous Flow Synthesis of Substituted 3,4-Propylenedioxythiophene Derivatives Org. Process Res. Dev. (IF 3.858) Pub Date : 2023-01-31 Dattatray L. Tarange, Nagaraj Nayak, Anil Kumar
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One-Pot Synthesis of Menthol from Citral over Ni/H-β-38 Extrudates Containing Bentonite Clay Binder in Batch and Continuous Reactors Org. Process Res. Dev. (IF 3.858) Pub Date : 2023-01-30 Irina L. Simakova, Zuzana Vajglová, Mark Martínez-Klimov, Kari Eränen, Markus Peurla, Päivi Mäki-Arvela, Dmitry Yu. Murzin
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Electrochemical Carbon-Ferrier Rearrangement Using a Microflow Reactor and Machine Learning-Assisted Exploration of Suitable Conditions Org. Process Res. Dev. (IF 3.858) Pub Date : 2023-01-27 Eisuke Sato, Gaku Tachiwaki, Mayu Fujii, Koichi Mitsudo, Takashi Washio, Shinobu Takizawa, Seiji Suga
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Scalable Synthesis of CVN424, an Inverse Agonist of the GPR6 Receptor Org. Process Res. Dev. (IF 3.858) Pub Date : 2023-01-26 Changwei Mu, Xiaolong Li, Yifang Yang, Yusheng Zhou, Chunhua Wang, Kevin J. Doyle, Naidong Ye, Anil Mistry, Roland W. Bürli
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Efficient and Scalable Asymmetric Total Synthesis of (−)-Emetine with Pharmaceutical Grade Quality; First Multigram Scale Synthesis Org. Process Res. Dev. (IF 3.858) Pub Date : 2023-01-24 Masatoshi Yamada, Kazuki Azuma, Iori Takizawa, Yuki Ejima, Mitsuhisa Yamano, Kimio Satoh, Takayuki Doi, Hirofumi Ueda, Hidetoshi Tokuyama
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Efficient Kilogram-Scale Synthesis of a Novel Oxazolidinone Antibacterial Candidate YG-056SP Org. Process Res. Dev. (IF 3.858) Pub Date : 2023-01-20 Yinyong Zhang, Yushe Yang, Xin Meng, Xianli Zhou, Bin Guo
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Synthesis of a Pyridoazepine Scaffold via Rhodium-Catalyzed Ring Expansion and Nitroacetamide Condensation Org. Process Res. Dev. (IF 3.858) Pub Date : 2023-01-16 Eddie Yang, Joseph W. Tucker, Thomas A. Chappie, John D. Weaver, Caroline Chapman, Remzi Duzguner, John M. Humphrey
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Generation of 1,2-Difluorobenzene via a Photochemical Fluorodediazoniation Step in a Continuous Flow Mode Org. Process Res. Dev. (IF 3.858) Pub Date : 2023-01-16 Kevin Simon, Desiree Znidar, Julien Boutet, Gérard Guillamot, Jean-Yves Lenoir, Doris Dallinger, C. Oliver Kappe
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Continuous Flow Epoxidation of Alkenes Using a Homogeneous Manganese Catalyst with Peracetic Acid Org. Process Res. Dev. (IF 3.858) Pub Date : 2023-01-14 Ailbhe A. Ryan, Seán D. Dempsey, Megan Smyth, Karen Fahey, Thomas S. Moody, Scott Wharry, Paul Dingwall, David W. Rooney, Jillian M. Thompson, Peter C. Knipe, Mark J. Muldoon
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Process Intensification and Increased Safety for the On-Demand Continuous Flow Synthesis of Dithiothreitol, a Crucial Component in Polymerase Chain Reaction Testing Kits Org. Process Res. Dev. (IF 3.858) Pub Date : 2023-01-11 Maryne A. J. Dubois, Virginie Carreras, Matt R. Adams, Vanessa Kairouz, Jean-François Vincent-Rocan, John G. Riley, André B. Charette
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A Cobalt-Containing Polysilane as an Effective Solid-State Catalyst for the Hydrosilylation of Alkenes Org. Process Res. Dev. (IF 3.858) Pub Date : 2023-01-09 Tatsuyoshi Ito, Yusuke Sunada
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Transformation of the Manufacturing Process from Discovery to Kilogram Scale for AWZ1066S: A Highly Specific Anti-Wolbachia Drug Candidate for a Short-Course Treatment of Filariasis Org. Process Res. Dev. (IF 3.858) Pub Date : 2023-01-10 W. David Hong, Paul M. O’Neill, Mark J. Taylor, Joseph D. Turner, Stephen A. Ward, Fabian Gusovsky, Farid Benayoud, Nao Shibuguchi, Dixit Girish, Francis Gerard Fang, Ravi Kumar Talabhakthla, Anand Vaddi, Chiranjeevi Challa, Karri Satya Ammi Reddy, Vijay Kalla, Sugandham Srinivasa Rao, Durga Mahesh Kumar Nagireddi, Jayesh Patel, Anil Shahaji Khile
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Some Items of Interest to Process R&D Chemists and Engineers Org. Process Res. Dev. (IF 3.858) Pub Date : 2023-01-09 Alan Steven, Robert B. Kargbo, Carlos Mateos, Andrei A. Zlota, Christopher C. Nawrat, James P. Phelan, Alexandre Barthelme, Sylvain Guizzetti, John Knight
This article has not yet been cited by other publications.
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Expeditious Synthesis of a Potent Allosteric HIV-1 Integrase Inhibitor GSK3839919A Org. Process Res. Dev. (IF 3.858) Pub Date : 2023-01-09 Mark A. Bobko, Jennifer M. Elward, B. Narasimhulu Naidu, Yexenia E. Nieves-Quinones, Christopher A. Reiher, Qiaogong Su, Liang Sun, John Woodard, Shiping Xie, Wuxing Yang, Yunxing Yin
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Large-Scale Amide Coupling in Aqueous Media: Process for the Production of Diazabicyclooctane β-Lactamase Inhibitors Org. Process Res. Dev. (IF 3.858) Pub Date : 2023-01-08 Yasinalli Tamboli, Jaydeo T. Kilbile, Arvind Y. Merwade
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Tracking the Isotopologues: Process Improvement for the Synthesis of a Deuterated Pyrazole Org. Process Res. Dev. (IF 3.858) Pub Date : 2023-01-06 Zachary J. Garlets, Elizabeth M. Yuill, Alice Yang, Qingmei Ye, Wei Ding, Christopher Wood, Junying Fan, Nicolas Lucien Cuniere, Chris Sfouggatakis
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Impurity Purging through Systematic Process Development of a Continuous Two-Stage Crystallization Org. Process Res. Dev. (IF 3.858) Pub Date : 2023-01-04 Drew Scott, Naomi E. B. Briggs, Anna Formosa, Annessa Burnett, Bimbisar Desai, Greg Hammersmith, Kersten Rapp, Gerard Capellades, Allan S. Myerson, Thomas D. Roper
更新日期：2023-03-26
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