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  • Cilostazol for Secondary Prevention of Stroke and Cognitive Decline
    Stroke (IF 7.19) Pub Date : 2020-07-10
    Caroline McHutchison; Gordon W. Blair; Jason P. Appleton; Francesca M. Chappell; Fergus Doubal; Philip M. Bath; Joanna M. Wardlaw

    Background and Purpose:Cilostazol, a phosphodiesterase 3’ inhibitor, is used in Asia-Pacific countries for stroke prevention, but rarely used elsewhere. In addition to weak antiplatelet effects, it stabilizes endothelium, aids myelin repair and astrocyte-neuron energy transfer in laboratory models, effects that may be beneficial in preventing small vessel disease progression.Methods:A systematic review

    更新日期:2020-07-10
  • Luminal and Wall Changes in Intracranial Arterial Lesions for Predicting Stroke Occurrence
    Stroke (IF 7.19) Pub Date : 2020-07-10
    Hyung Jun Kim; Eun-Hyeok Choi; Jong-Won Chung; Jae-Hwan Kim; Ye Sel Kim; Woo-Keun Seo; Gyeong-Moon Kim; Oh Young Bang

    Background and Purpose:Luminal imaging (degree of stenosis) currently serves as the gold standard to predict stroke recurrence and guide therapeutic strategies in patients with intracranial large artery diseases (ILADs). We comparatively evaluated the importance of vessel wall and luminal changes in predicting stroke occurrence.Methods:Consecutive patients with ILAD in the proximal middle cerebral

    更新日期:2020-07-10
  • Pathophysiology of Intracranial Aneurysms
    Stroke (IF 7.19) Pub Date : 2020-07-10
    Jan Rodemerk; Andreas Junker; Bixia Chen; Daniela Pierscianek; Philipp Dammann; Marvin Darkwah Oppong; Alexander Radbruch; Michael Forsting; Stefan Maderwald; Harald H. Quick; Yuan Zhu; Ramazan Jabbarli; Ulrich Sure; Karsten H. Wrede

    Background and Purpose:The pathophysiology of development, growth, and rupture of intracranial aneurysms (IAs) is only partly understood. Cyclooxygenase 2 (COX-2) converts arachidonic acid to prostaglandin H2, which, in turn, is isomerized to prostaglandin E2. In the human body, COX-2 plays an essential role in inflammatory pathways. This explorative study aimed to investigate COX-2 expression in the

    更新日期:2020-07-10
  • Safety of Anticoagulation in Patients Treated With Urgent Reperfusion for Ischemic Stroke Related to Atrial Fibrillation
    Stroke (IF 7.19) Pub Date : 2020-07-10
    Michela Giustozzi; Monica Acciarresi; Giancarlo Agnelli; Valeria Caso; Fabio Bandini; Georgios Tsivgoulis; Shadi Yaghi; Karen L. Furie; Prasanna Tadi; Cecilia Becattini; Marialuisa Zedde; Azmil H. Abdul-Rahim; Kennedy R. Lees; Andrea Alberti; Michele Venti; Cataldo D’Amore; Maria Giulia Mosconi; Ludovica Anna Cimini; Paolo Bovi; Monica Carletti; Alberto Rigatelli; Manuel Cappellari; Jukka Putaala;

    Background and Purpose:The optimal timing for starting oral anticoagulant after an ischemic stroke related to atrial fibrillation remains a challenge, mainly in patients treated with systemic thrombolysis or mechanical thrombectomy. We aimed at assessing the incidence of early recurrence and major bleeding in patients with acute ischemic stroke and atrial fibrillation treated with thrombolytic therapy

    更新日期:2020-07-10
  • Risk and Secondary Prevention of Stroke Recurrence
    Stroke (IF 7.19) Pub Date : 2020-07-10
    Clare Flach; Walter Muruet; Charles D.A. Wolfe; Ajay Bhalla; Abdel Douiri

    Background and Purpose:With recent advances in secondary prevention management, stroke recurrence rates may have changed substantially. We aim to estimate risks and trends of stroke recurrence over the past 2 decades in a population-based cohort of patients with stroke.Methods:Patients with a first-ever stroke between 1995 and 2018 in South London, United Kingdom (n=6052) were collected and analyzed

    更新日期:2020-07-10
  • Burden of Stroke in Europe
    Stroke (IF 7.19) Pub Date : 2020-07-10
    Hatem A. Wafa; Charles D.A. Wolfe; Eva Emmett; Gregory A. Roth; Catherine O. Johnson; Yanzhong Wang

    Background and purpose:Prediction of stroke impact provides essential information for healthcare planning and priority setting. We aim to estimate 30-year projections of stroke epidemiology in the European Union using multiple modeling approaches.Methods:Data on stroke incidence, prevalence, deaths, and disability-adjusted life years in the European Union between 1990 and 2017 were obtained from the

    更新日期:2020-07-10
  • Infarct Volume Before Hemicraniectomy in Large Middle Cerebral Artery Infarcts Poorly Predicts Catastrophic Outcome
    Stroke (IF 7.19) Pub Date : 2020-07-10
    Barbara Casolla; Gregory Kuchcinski; Maéva Kyheng; Riyad Hanafi; Jean-Paul Lejeune; Didier Leys; Charlotte Cordonnier; Hilde Hénon

    Background and Purpose:Infarct volumes predict malignant infarcts in patients undergoing decompressive hemicraniectomy (DH) for large middle cerebral artery territory infarcts. The aim of the study was to determine the optimal magnetic resonance imaging infarct volume threshold that predicts a catastrophic outcome at 1 year (modified Rankin Scale score of 5 or death).Methods:We included consecutive

    更新日期:2020-07-10
  • Compliance With Imaging Guidelines for Workup of Transient Ischemic Attack: Evidence From the Nationwide Emergency Department Sample
    Stroke (IF 7.19) Pub Date : 2020-07-10
    Vincent M. Timpone; Alexandria Jensen; Sharon N. Poisson; Premal S. Trivedi

    Background and Purpose:Multiple societal guidelines recommend urgent brain and neurovascular imaging in patients with transient ischemic attack (TIA) to identify and treat risk factors that may lead to future stroke. The purpose of this study was to evaluate whether national imaging utilization for workup of TIA complies with society guidelines.Methods:Analysis utilized the Nationwide Emergency Department

    更新日期:2020-07-10
  • Characteristics and Outcomes in Patients With COVID-19 and Acute Ischemic Stroke
    Stroke (IF 7.19) Pub Date : 2020-07-09
    George Ntaios; Patrik Michel; Georgios Georgiopoulos; Yutao Guo; Wencheng Li; Jing Xiong; Patricia Calleja; Fernando Ostos; Guillermo González-Ortega; Blanca Fuentes; María Alonso de Leciñana; Exuperio Díez-Tejedor; Sebastian García-Madrona; Jaime Masjuan; Alicia DeFelipe; Guillaume Turc; Bruno Gonçalves; Valerie Domigo; Gheorghe-Andrei Dan; Roxana Vezeteu; Hanne Christensen; Louisa Marguerite Christensen;

    Recent case-series of small size implied a pathophysiological association between coronavirus disease 2019 (COVID-19) and severe large-vessel acute ischemic stroke. Given that severe strokes are typically associated with poor prognosis and can be very efficiently treated with recanalization techniques, confirmation of this putative association is urgently warranted in a large representative patient

    更新日期:2020-07-10
  • Utility-Weighted Modified Rankin Scale Scores for the Assessment of Stroke Outcome
    Stroke (IF 7.19) Pub Date : 2020-07-09
    Xia Wang; Tom J. Moullaali; Qiang Li; Eivind Berge; Thompson G. Robinson; Richard Lindley; Danni Zheng; Candice Delcourt; Hisatomi Arima; Lili Song; Xiaoying Chen; Jie Yang; John Chalmers; Craig S. Anderson; Else Charlotte Sandset

    Background and Purpose:Patient-centered care prioritizes patient beliefs and values towards wellbeing. We aimed to map functional status (modified Rankin Scale [mRS] scores) and health-related quality of life on the European Quality of Life 5-dimensional questionnaire (EQ-5D) to derive utility-weighted (UW) stroke outcome measures and test their statistical properties and construct validity.Methods:UW-mRS

    更新日期:2020-07-09
  • Modifiable Risk Factors Associated With Moyamoya Disease
    Stroke (IF 7.19) Pub Date : 2020-07-09
    Peicong Ge; Qian Zhang; Xun Ye; Xingju Liu; Xiaofeng Deng; Jia Wang; Rong Wang; Yan Zhang; Dong Zhang; Jizong Zhao

    Background and Purpose:The cause of moyamoya disease (MMD) remains unknown. We aimed to investigate the association between modifiable risk factors and MMD in a prospective, case-control study.Methods:Clinical and laboratory characteristics were evaluated in consecutively recruited adult patients with MMD and age-matched healthy control individuals. The potential risk factors for MMD were estimated

    更新日期:2020-07-09
  • Peri-Infarct Hot-Zones Have Higher Susceptibility to Optogenetic Functional Activation-Induced Spreading Depolarizations
    Stroke (IF 7.19) Pub Date : 2020-07-09
    Kazutaka Sugimoto; David Y. Chung; Maximilian Böhm; Paul Fischer; Tsubasa Takizawa; Sanem Aslihan Aykan; Tao Qin; Takeshi Yanagisawa; Andrea Harriott; Fumiaki Oka; Mohammad A. Yaseen; Sava Sakadžić; Cenk Ayata

    Background and Purpose:Spreading depolarizations (SDs) are recurrent and ostensibly spontaneous depolarization waves that may contribute to infarct progression after stroke. Somatosensory activation of the metastable peri-infarct tissue triggers peri-infarct SDs at a high rate.Methods:We directly measured the functional activation threshold to trigger SDs in peri-infarct hot zones using optogenetic

    更新日期:2020-07-09
  • Direct-Acting Oral Anticoagulants Versus Warfarin in Medicare Patients With Chronic Kidney Disease and Atrial Fibrillation
    Stroke (IF 7.19) Pub Date : 2020-07-09
    James B. Wetmore; Nicholas S. Roetker; Heng Yan; Jorge L. Reyes; Charles A. Herzog

    Background and Purpose:The comparative effectiveness of direct-acting oral anticoagulants, compared with warfarin, for risks of stroke/systemic embolism, major bleeding, or death have not been studied in Medicare beneficiaries with atrial fibrillation and nondialysis-dependent chronic kidney disease.Methods:Medicare data from 2011 to 2017 were used to identify patients with stages 3, 4, or 5 chronic

    更新日期:2020-07-09
  • Impact of Goal-Directed Therapy on Delayed Ischemia After Aneurysmal Subarachnoid Hemorrhage
    Stroke (IF 7.19) Pub Date : 2020-07-09
    Aida Anetsberger; Jens Gempt; Manfred Blobner; Florian Ringel; Ralf Bogdanski; Markus Heim; Gerhard Schneider; Bernhard Meyer; Sebastian Schmid; Yu-Mi Ryang; Maria Wostrack; Jürgen Schneider; Jan Martin; Maximilian Ehrhardt; Bettina Jungwirth

    Background and Purpose:Delayed cerebral ischemia (DCI) is the most important cause for a poor clinical outcome after a subarachnoid hemorrhage. The aim of this study was to assess whether goal-directed hemodynamic therapy (GDHT), as compared to standard clinical care, reduces the rate of DCI after subarachnoid hemorrhage.Methods:We conducted a prospective randomized controlled trial. Patients >18 years

    更新日期:2020-07-09
  • Provincial Door-to-Needle Improvement Initiative Results in Improved Patient Outcomes Across an Entire Population
    Stroke (IF 7.19) Pub Date : 2020-07-09
    Noreen Kamal; Thomas Jeerakathil; Jillian Stang; Mingfu Liu; Edwin Rogers; Eric E. Smith; Andrew M. Demchuk; Muzaffar Siddiqui; Balraj Mann; Jennifer Bestard; Eddy Lang; Elaine Shand; Magali Benard; Lisa Collins; Kevin Martin; Corinna Hartley; Marnie Reiber; Shelley Valaire; Kelly J. Mrklas; Michael D. Hill

    Background and Purpose:Improving door-to-needle times (DNTs) for thrombolysis of acute ischemic stroke patients improves outcomes, but participation in DNT improvement initiatives has been mostly limited to larger, academic medical centers with an existing interest in stroke quality improvement. It is not known whether quality improvement initiatives can improve DNT at a population level, including

    更新日期:2020-07-09
  • Sustained Increases in Immune Transcripts and Immune Cell Trafficking During the Recovery of Experimental Brain Ischemia
    Stroke (IF 7.19) Pub Date : 2020-07-09
    Wen Fury; Keun Woo Park; Zhuhao Wu; Eunhee Kim; Moon-sook Woo; Yu Bai; Lynn E. Macdonald; Susan D. Croll; Sunghee Cho

    Background and Purpose:Stroke is a major cause of chronic neurological disability. There is considerable interest in understanding how acute transcriptome changes evolve into subacute and chronic patterns that facilitate or limit spontaneous recovery. Here we mapped longitudinal changes in gene expression at multiple time points after stroke in mice out to 6 months.Methods:Adult C57BL/6 mice were subjected

    更新日期:2020-07-09
  • High-Sensitivity Cardiac Troponin T for Risk Stratification in Patients With Embolic Stroke of Undetermined Source
    Stroke (IF 7.19) Pub Date : 2020-07-09
    Jan F. Scheitz; Guillaume Pare; Lesly A. Pearce; Hardi Mundl; W. Frank Peacock; Anna Czlonkowska; Mukul Sharma; Christian H. Nolte; Ashkan Shoamanesh; Scott D. Berkowitz; Thomas Krahn; Matthias Endres; on behalf of the NAVIGATE-ESUS Biomarker Working Group

    Background and Purpose:Optimal secondary prevention for patients with embolic stroke of undetermined source (ESUS) remains unknown. We aimed to assess whether high-sensitivity cardiac troponin T (hs-cTnT) levels are associated with major vascular events and whether hs-cTnT may identify patients who benefit from anticoagulation following ESUS.Methods:Data were obtained from the biomarker substudy of

    更新日期:2020-07-09
  • Disentangling Sex Differences in Use of Reperfusion Therapy in Patients With Acute Ischemic Stroke
    Stroke (IF 7.19) Pub Date : 2020-07-09
    Jeppe Mainz; Grethe Andersen; Jan Brink Valentin; Martin Faurholdt Gude; Søren Paaske Johnsen

    Background and Purpose:Previous studies from local settings have reported that women with acute ischemic stroke have a lower chance of receiving reperfusion therapy treatment, including intravenous thrombolysis and thrombectomy, than men, but the underlying mechanisms of this disparity have not been identified. We aimed to examine sex differences in the utilization of reperfusion therapy focusing on

    更新日期:2020-07-09
  • Prevalence and Outcome of Potential Candidates for Left Atrial Appendage Closure After Stroke With Atrial Fibrillation
    Stroke (IF 7.19) Pub Date : 2020-07-09
    Elodie Ong; Elena Meseguer; Celine Guidoux; Philippa C. Lavallée; Cristina Hobeanu; Hugo Charles; Julien Labreuche; Lucie Cabrejo; Anna Martin-Bechet; Ricardo Rigual; Norbert Nighoghossian; Pierre Amarenco

    Background and Purpose:As a result of contraindications (eg, frailty, cognitive impairment, comorbidities) or patient refusal, many patients with stroke and atrial fibrillation cannot be discharged on oral anticoagulant. Among them, the proportion of potential candidates for left atrial appendage closure (LAAC) and their 12-month outcome is not well known.Methods:The prospective WATCH-AF registry (Warfarin

    更新日期:2020-07-09
  • COVID-19 and Decompressive Hemicraniectomy for Acute Ischemic Stroke
    Stroke (IF 7.19) Pub Date : 2020-07-08
    John W. Liang; Alexandra S. Reynolds; Kaitlin Reilly; Cappi Lay; Christopher P. Kellner; Tomoyoshi Shigematsu; Jeffrey Gilligan; Shahram Majidi; Fawaz Al-Mufti; Joshua B. Bederson; J. Mocco; Mandip S. Dhamoon; Neha S. Dangayach; on behalf of the Mount Sinai Stroke Investigators

    Background and Purpose:Young patients with malignant cerebral edema have been shown to benefit from early decompressive hemicraniectomy. The impact of concomitant infection with coronavirus disease 2019 (COVID-19) and how this should weigh in on the decision for surgery is unclear.Methods:We retrospectively reviewed all COVID-19–positive patients admitted to the neuroscience intensive care unit for

    更新日期:2020-07-08
  • Effect of COVID-19 on Emergent Stroke Care
    Stroke (IF 7.19) Pub Date : 2020-07-08
    Jessica Hsiao; Emily Sayles; Eleni Antzoulatos; Robert J. Stanton; Heidi Sucharew; Joseph P. Broderick; Stacie L. Demel; Matthew L. Flaherty; Aaron W. Grossman; Charles Kircher; Natalie Kreitzer; Katrina Peariso; Charles J. Prestigiacomo; Peyman Shirani; Kyle B. Walsh; Holly Lampton; Opeolu Adeoye; Pooja Khatri

    Background and Purpose:Anecdotal evidence suggests that the coronavirus disease 2019 (COVID-19) pandemic mitigation efforts may inadvertently discourage patients from seeking treatment for stroke with resultant increased morbidity and mortality. Analysis of regional data, while hospital capacities for acute stroke care remained fully available, offers an opportunity to assess this. We report regional

    更新日期:2020-07-08
  • Sex Differences in Blood Pressure–Lowering Therapy and Outcomes Following Intracerebral Hemorrhage
    Stroke (IF 7.19) Pub Date : 2020-07-06
    Mayumi Fukuda-Doi; Haruko Yamamoto; Masatoshi Koga; Yuko Y. Palesch; Valerie L. Durkalski-Mauldin; Adnan I. Qureshi; Sohei Yoshimura; Shuhei Okazaki; Kaori Miwa; Yasushi Okada; Toshihiro Ueda; Satoshi Okuda; Jin Nakahara; Norihiro Suzuki; Kazunori Toyoda

    Background and Purpose:Evidence regarding sex differences in clinical outcomes and treatment effect following intracerebral hemorrhage is limited. Using the ATACH-2 trial (Antihypertensive Treatment in Intracerebral Hemorrhage-2) data, we explored whether sex disparities exist in outcomes and response to intensive blood pressure (BP)–lowering therapy.Methods:Eligible intracerebral hemorrhage subjects

    更新日期:2020-07-06
  • Alteplase for Acute Ischemic Stroke in Patients Aged >80 Years
    Stroke (IF 7.19) Pub Date : 2020-07-02
    Erich Bluhmki; Thierry Danays; Gabriele Biegert; Werner Hacke; Kennedy R. Lees

    Background/Purpose:Expert guidelines specify no upper age limit for alteplase for thrombolysis of acute ischemic stroke (AIS) but, until recently, European regulatory criteria restricted its use to patients aged 18 to 80 years. We performed pooled analyses of randomized controlled trial (RCT) and registry data to evaluate the benefit-risk profile of alteplase for AIS among patients aged >80 years to

    更新日期:2020-07-02
  • Predictors and Functional Outcomes of Fast, Intermediate, and Slow Progression Among Patients With Acute Ischemic Stroke
    Stroke (IF 7.19) Pub Date : 2020-07-02
    Woo-Keun Seo; David S. Liebeskind; Bryan Yoo; Latisha Sharma; Reza Jahan; Gary Duckwiler; Satoshi Tateshima; May Nour; Viktor Szeder; Geoffrey Colby; Sidney Starkman; Neal Rao; Mersedeh Bahr Hosseini; Jeffrey L. Saver; for the UCLA Penumbra Imaging Investigators

    Background and Purpose:We aimed to delineate the determinants of the initial speed of infarct progression and the association of speed of infarct progression (SIP) with procedural and functional outcomes.Methods:From a prospectively maintained stroke center registry, consecutive anterior circulation ischemic stroke patients with large artery occlusion, National Institute of Health Stroke Scale score

    更新日期:2020-07-02
  • Acute Stroke Management During the COVID-19 Pandemic
    Stroke (IF 7.19) Pub Date : 2020-07-01
    Steven D. Hajdu; Valerie Pittet; Francesco Puccinelli; Wagih Ben Hassen; Malek Ben Maacha; Raphaël Blanc; Sandra Bracco; Gabriel Broocks; Bruno Bartolini; Tommaso Casseri; Frederic Clarençon; Olivier Naggara; François Eugène; Jean-Christophe Ferré; Alexis Guédon; Emmanuel Houdart; Timo Krings; Pierre Lehmann; Nicola Limbucci; Paolo Machi; Juan Macho; Nicolo Mandruzzato; Sergio Nappini; Marie Teresa

    During the coronavirus disease 2019 (COVID-19) pandemic, the World Health Organization recommended measures to mitigate the outbreak such as social distancing and confinement. Since these measures have been put in place, anecdotal reports describe a decrease in the number of endovascular therapy (EVT) treatments for acute ischemic stroke due to large vessel occlusion. The purpose of our study was to

    更新日期:2020-07-01
  • Multiphasic Computed Tomography Angiography Findings for Identifying Pseudo-Occlusion of the Internal Carotid Artery
    Stroke (IF 7.19) Pub Date : 2020-06-26
    Jai Ho Choi; Jinhee Jang; Jaseong Koo; Kook-Jin Ahn; Yong Sam Shin; Bum-soo Kim

    Background and Purpose:Differentiation between pseudo-occlusion and true occlusion of internal carotid artery (ICA) is important in treatment planning for acute ischemic stroke patients. We compared the findings of multiphasic computed tomography angiography between cervical ICA pseudo-occlusion and true occlusion at the cervical ICA in patients with anterior circulation acute ischemic stroke to determine

    更新日期:2020-06-26
  • In-Hospital Delays in Stroke Thrombolysis
    Stroke (IF 7.19) Pub Date : 2020-06-26
    David Darehed; Mathias Blom; Eva-Lotta Glader; Johan Niklasson; Bo Norrving; Marie Eriksson

    Background and Purpose:Intravenous thrombolysis is a well-established treatment for acute ischemic stroke. Our aim was to quantify the effect of each minute delay in door-to-needle time (DNT) on 90-day survival, intracerebral hemorrhagic complication <36 hours, and functional outcomes at 3 months, in routine clinical practice.Methods:Our nationwide registry-based study included 14 132 adult patient

    更新日期:2020-06-26
  • Impact of Infection on the Risk of Recurrent Stroke Among Patients With Acute Ischemic Stroke
    Stroke (IF 7.19) Pub Date : 2020-06-26
    Jie Xu; Gulbahram Yalkun; Meng Wang; Anxin Wang; Runqi Wangqin; Xiaoli Zhang; Zimo Chen; Jinglin Mo; Xia Meng; Hao Li; Zixiao Li; Yongjun Wang

    Background and Purpose:Infection occurs commonly in patients with acute ischemic stroke. We aimed to investigate the association of infection with short- and long-term risk of recurrent stroke in patients with ischemic stroke.Methods:Data were derived from ischemic stroke patients in 2 stroke registries: the CSCA (Chinese Stroke Center Alliance) program recorded medical data during hospitalization

    更新日期:2020-06-26
  • Telemedicine Cognitive Behavioral Therapy for Anxiety After Stroke
    Stroke (IF 7.19) Pub Date : 2020-06-24
    Ho-Yan Yvonne Chun; Alan J. Carson; Athanasios Tsanas; Martin S. Dennis; Gillian E. Mead; Clementina Calabria; William N. Whiteley

    Background and Purpose:Disabling anxiety affects a quarter of stroke survivors but access to treatment is poor. We developed a telemedicine model for delivering guided self-help cognitive behavioral therapy (CBT) for anxiety after stroke (TASK-CBT). We aimed to evaluate the feasibility of TASK-CBT in a randomized controlled trial workflow that enabled all trial procedures to be carried out remotely

    更新日期:2020-06-24
  • Pandemic Guidance for Stroke Centers Aiding COVID-19 Treatment Teams
    Stroke (IF 7.19) Pub Date : 2020-06-23
    Charles R. Wira; Mayank Goyal; Andrew M. Southerland; Kevin N. Sheth; Norma D. McNair; Houman Khosravani; Anne Leonard; Peter Panagos; on behalf of the AHA/ASA Stroke Council Science Subcommittees: Emergency Neurovascular Care (ENCC), Telestroke and the Neurovascular Intervention Committees; and on behalf of the Stroke Nursing Science Subcommittee of the AHA/ASA Cardiovascular and Stroke Nursing Council

    The coronavirus disease 2019 (COVID-19) pandemic has in some regions overwhelmed the capacity and staffing needs of healthcare systems, necessitating the provision of resources and staff from different disciplines to aid COVID treatment teams. Stroke centers have multidisciplinary clinical and procedural expertise to support COVID treatment teams. Staff safety and patient safety are essential, as are

    更新日期:2020-06-24
  • John W. Norris: 1933-2020.
    Stroke (IF 7.19) Pub Date : 2020-05-22
    Vladimir Hachinski,Natan M Bornstein,Hugh S Markus

    Stroke is a relatively recent field. No history of vascular neurology would be complete without the name of John W. Norris. We have lost him to coronavirus disease 2019 (COVID-19), but his contributions continue to have an impact. He came into the world in Portsmouth, United Kingdom as the first of 3 children born to an Irish father and an English mother. He had a rough beginning in school during the

    更新日期:2020-06-23
  • In Memoriam: Robert J. Wityk.
    Stroke (IF 7.19) Pub Date : 2020-06-17
    Argye E Hillis

    Robert J. Wityk, MD, Associate Professor of Neurology at Johns Hopkins, born June 6, 1959 in Cleveland Ohio, died March 26, 2020 in Timonium, MD of a brain tumor. Bob grew up in Maryland, where he attended Loyola High School. Even in High School, he achieved national recognition as a member of the speech and debate team. He was also the co-founder of The Loyola Gentleman’s Literary Companion, a humor

    更新日期:2020-06-23
  • Farewell and Thank You.
    Stroke (IF 7.19) Pub Date : 2020-06-16
    Marc Fisher

    I have completed my 10-year term as Editor-in-Chief of Stroke as of June 30, 2020. It has been a very rewarding and enriching experience on multiple levels. The past 10 years have seen tremendous advances in the stroke field in regards to acute ischemic stroke diagnostics and treatment. Stroke prevention modalities have also advanced. Advances have occurred albeit at a slower pace for patients with

    更新日期:2020-06-23
  • Charting a New Course for Stroke 2020.
    Stroke (IF 7.19) Pub Date : 2020-06-10
    Ralph L Sacco

    With this July 2020 issue, I officially begin my term as Editor-In-Chief of our Stroke journal. We stand on the shoulders of giants for all those who have contributed to this journal over the last 50 years. Our field has rapidly advanced and so has the journal over the decades, but we would not be where we are today without the dedicated work of so many authors, reviewers, and editors. I start my term

    更新日期:2020-06-23
  • The Curious Case of the Missing Strokes During the COVID-19 Pandemic.
    Stroke (IF 7.19) Pub Date : 2020-05-29
    Diana Aguiar de Sousa,Else Charlotte Sandset,Mitchell S V Elkind

    See related articles, p 1991 and p 1996 Despite worldwide efforts, the incidence of coronavirus disease 2019 (COVID-19) continues to increase. To address this ongoing public health emergency, most countries implemented strict social containment measures and reorganized health care systems. Although these were necessary changes to contain the spread of disease and to deal with a rapidly rising number

    更新日期:2020-06-23
  • Ischemic Stroke Epidemiology During the COVID-19 Pandemic: Navigating Uncharted Waters With Changing Tides.
    Stroke (IF 7.19) Pub Date : 2020-06-04
    Georgios Tsivgoulis,Aristeidis H Katsanos,Raffaele Ornello,Simona Sacco

    See related articles, p 2003 and p 2220 In December 2019, a novel coronavirus causing pneumonia and severe acute respiratory syndrome emerged in Wuhan, China.1 The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has quickly spread worldwide, and pandemic outbreak of coronavirus disease 2019 (COVID-19) was declared by the World Health Organization on March 11, 2020.1 During this pandemic

    更新日期:2020-06-23
  • Path From Clinical Research to Implementation: Endovascular Treatment of Ischemic Stroke in the Netherlands.
    Stroke (IF 7.19) Pub Date : 2020-06-17
    Eveline J A Wiegers,Kars C J Compagne,Paula M Janssen,Esmee Venema,Jaap W Deckers,Wouter J Schonewille,Jan Albert Vos,Geert J Lycklama À Nijeholt,Bob Roozenbeek,Jasper M Martens,Jeannette Hofmeijer,Robert-Jan van Oostenbrugge,Wim H van Zwam,Charles B L M Majoie,Aad van der Lugt,H F Lingsma,Yvo B W E M Roos,Diederik W J Dippel,

    Before 2015, endovascular treatment (EVT) for acute ischemic stroke was considered a promising treatment option. Based on limited evidence, it was performed in several dedicated stroke centers worldwide on selected patients. Since 2015, EVT for patients with intracranial large vessel occlusion has quickly been implemented as standard treatment in many countries worldwide, supported by the revised international

    更新日期:2020-06-23
  • Theophylline as an Add-On to Thrombolytic Therapy in Acute Ischemic Stroke: A Randomized Placebo-Controlled Trial.
    Stroke (IF 7.19) Pub Date : 2020-06-17
    Boris Modrau,Grethe Andersen,Irene Klærke Mikkelsen,Anne Nielsen,Mikkel Bo Hansen,Martin Berg Johansen,Helle Wulf Eskildsen,Jan Plougmann Povlsen,Yousef Yavarian,Kim Mouridsen,Leif Østergaard,Flemming Winther Bach,Niels Hjort

    Background and Purpose:Delayed recanalization increases the risk of infarct growth and poor clinical outcome in acute ischemic stroke. The vasoactive agent theophylline has shown neuroprotective effects in animal stroke models but inconclusive results in case series and randomized clinical trials. The primary objective of this study was to evaluate whether theophylline, as an add-on to thrombolytic

    更新日期:2020-06-23
  • Acute Stroke Care Is at Risk in the Era of COVID-19: Experience at a Comprehensive Stroke Center in Barcelona.
    Stroke (IF 7.19) Pub Date : 2020-05-22
    Salvatore Rudilosso,Carlos Laredo,Víctor Vera,Martha Vargas,Arturo Renú,Laura Llull,Víctor Obach,Sergio Amaro,Xabier Urra,Ferrán Torres,Francesc Xavier Jiménez-Fàbrega,Ángel Chamorro

    Background and Purpose:The purpose of the study is to analyze how the coronavirus disease 2019 (COVID-19) pandemic affected acute stroke care in a Comprehensive Stroke Center.Methods:On February 28, 2020, contingency plans were implemented at Hospital Clinic of Barcelona to contain the COVID-19 pandemic. Among them, the decision to refrain from reallocating the Stroke Team and Stroke Unit to the care

    更新日期:2020-06-23
  • Impact of the COVID-19 Epidemic on Stroke Care and Potential Solutions.
    Stroke (IF 7.19) Pub Date : 2020-05-20
    Jing Zhao,Hang Li,David Kung,Marc Fisher,Ying Shen,Renyu Liu

    Background and Purpose:When the coronavirus disease 2019 (COVID-19) outbreak became paramount, medical care for other devastating diseases was negatively impacted. In this study, we investigated the impact of the COVID-19 outbreak on stroke care across China.Methods:Data from the Big Data Observatory Platform for Stroke of China consisting of 280 hospitals across China demonstrated a significant drop

    更新日期:2020-06-23
  • SARS-CoV-2 and Stroke in a New York Healthcare System.
    Stroke (IF 7.19) Pub Date : 2020-05-20
    Shadi Yaghi,Koto Ishida,Jose Torres,Brian Mac Grory,Eytan Raz,Kelley Humbert,Nils Henninger,Tushar Trivedi,Kaitlyn Lillemoe,Shazia Alam,Matthew Sanger,Sun Kim,Erica Scher,Seena Dehkharghani,Michael Wachs,Omar Tanweer,Frank Volpicelli,Brian Bosworth,Aaron Lord,Jennifer Frontera

    Background and Purpose:With the spread of coronavirus disease 2019 (COVID-19) during the current worldwide pandemic, there is mounting evidence that patients affected by the illness may develop clinically significant coagulopathy with thromboembolic complications including ischemic stroke. However, there is limited data on the clinical characteristics, stroke mechanism, and outcomes of patients who

    更新日期:2020-06-23
  • Mechanical Thrombectomy for Acute Ischemic Stroke Amid the COVID-19 Outbreak: Decreased Activity, and Increased Care Delays.
    Stroke (IF 7.19) Pub Date : 2020-05-20
    Basile Kerleroux,Thibaut Fabacher,Nicolas Bricout,Martin Moïse,Benoit Testud,Sivadji Vingadassalom,Héloïse Ifergan,Kévin Janot,Arturo Consoli,Wagih Ben Hassen,Eimad Shotar,Julien Ognard,Guillaume Charbonnier,Vincent L'Allinec,Alexis Guédon,Federico Bolognini,Gaultier Marnat,Géraud Forestier,Aymeric Rouchaud,Raoul Pop,Nicolas Raynaud,François Zhu,Jonathan Cortese,Vanessa Chalumeau,Jérome Berge,Simon

    Background and Purpose:The efficiency of prehospital care chain response and the adequacy of hospital resources are challenged amid the coronavirus disease 2019 (COVID-19) outbreak, with suspected consequences for patients with ischemic stroke eligible for mechanical thrombectomy (MT).Methods:We conducted a prospective national-level data collection of patients treated with MT, ranging 45 days across

    更新日期:2020-06-23
  • Intravenous Fibrinolysis for Central Retinal Artery Occlusion: A Cohort Study and Updated Patient-Level Meta-Analysis.
    Stroke (IF 7.19) Pub Date : 2020-06-17
    Brian Mac Grory,Alex Nackenoff,Sven Poli,Martin S Spitzer,Max Nedelmann,Benoit Guillon,Cécile Preterre,Celia S Chen,Andrew W Lee,Shadi Yaghi,Christoph Stretz,Idrees Azher,John Paddock,Tatiana Bakaeva,David M Greer,Julie G Shulman,Robert G Kowalski,Patrick Lavin,Eva Mistry,Kiersten Espaillat,Karen Furie,Howard Kirshner,Matthew Schrag

    Background and Purpose:Central retinal artery occlusion results in sudden, painless, usually permanent loss of vision in the affected eye. There is no proven, effective treatment to salvage visual acuity and a clear, unmet need for an effective therapy. In this work, we evaluated the efficacy of intravenous tissue-type plasminogen activator (IV alteplase) in a prospective cohort study and an updated

    更新日期:2020-06-23
  • Efficacy and Safety of Recanalization Therapy for Acute Ischemic Stroke With Large Vessel Occlusion: A Systematic Review.
    Stroke (IF 7.19) Pub Date : 2020-06-03
    Wen Hui,Chuanjie Wu,Wenbo Zhao,Huan Sun,Jun Hao,Hongyan Liang,Xian Wang,Ming Li,Ashutosh P Jadhav,Youli Han,Xunming Ji

    Background and Purpose:The optimal recanalization strategy for acute ischemic stroke with large vessel occlusion continues to be an area of active interest. Network meta-analysis can provide insight when direct comparative evidence is lacking.Methods:A systematic review of the literature using PubMed, Embase, the Cochrane Central Register of Controlled Trials, and SinoMed was performed, and a search

    更新日期:2020-06-23
  • General Anesthesia Versus Conscious Sedation and Local Anesthesia During Thrombectomy for Acute Ischemic Stroke.
    Stroke (IF 7.19) Pub Date : 2020-06-10
    Manuel Cappellari,Giovanni Pracucci,Stefano Forlivesi,Valentina Saia,Sergio Nappini,Patrizia Nencini,Domenico Inzitari,Laura Greco,Fabrizio Sallustio,Stefano Vallone,Guido Bigliardi,Andrea Zini,Antonio Pitrone,Francesco Grillo,Rosa Musolino,Sandra Bracco,Rebecca Tinturini,Rossana Tassi,Mauro Bergui,Paolo Cerrato,Andrea Saletti,Alessandro De Vito,Ilaria Casetta,Roberto Gasparotti,Mauro Magoni,Lucio

    Background and Purpose:As numerous questions remain about the best anesthetic strategy during thrombectomy, we assessed functional and radiological outcomes in stroke patients treated with thrombectomy in presence of general anesthesia (GA) versus conscious sedation (CS) and local anesthesia (LA).Methods:We conducted a cohort study on prospectively collected data from 4429 patients enrolled in the

    更新日期:2020-06-23
  • Mechanical Thrombectomy in Basilar Artery Occlusion: Clinical Outcomes Related to Posterior Circulation Collateral Score.
    Stroke (IF 7.19) Pub Date : 2020-06-17
    Hyo Sung Kwak,Jung Soo Park

    Background and Purpose:Basilar artery occlusion (BAO) is associated with a high risk of disability and mortality. The objective of this study was to investigate prognostic factors in patients with acute basilar artery occlusion treated with mechanical thrombectomy, focusing on collateral status and recanalization time from symptom onset.Methods:Eligible patients from January 2012 to October 2019 who

    更新日期:2020-06-23
  • Endovascular Thrombectomy for Acute Ischemic Stroke Beyond 6 Hours From Onset: A Real-World Experience.
    Stroke (IF 7.19) Pub Date : 2020-06-17
    Ilaria Casetta,Enrico Fainardi,Valentina Saia,Giovanni Pracucci,Marina Padroni,Leonardo Renieri,Patrizia Nencini,Domenico Inzitari,Daniele Morosetti,Fabrizio Sallustio,Stefano Vallone,Guido Bigliardi,Andrea Zini,Marcello Longo,Isabella Francalanza,Sandra Bracco,Ignazio M Vallone,Rossana Tassi,Mauro Bergui,Andrea Naldi,Andrea Saletti,Alessandro De Vito,Roberto Gasparotti,Mauro Magoni,Lucio Castellan

    Background and Purpose:To evaluate outcome and safety of endovascular treatment beyond 6 hours of onset of ischemic stroke due to large vessel occlusion in the anterior circulation, in routine clinical practice.Methods:From the Italian Registry of Endovascular Thrombectomy, we extracted clinical and outcome data of patients treated for stroke of known onset beyond 6 hours. Additional inclusion criteria

    更新日期:2020-06-23
  • Efficacy of Clopidogrel for Prevention of Stroke Based on CYP2C19 Allele Status in the POINT Trial.
    Stroke (IF 7.19) Pub Date : 2020-06-17
    James F Meschia,Ronald L Walton,Luca P Farrugia,Owen A Ross,Jordan J Elm,Mary Farrant,William J Meurer,Anne S Lindblad,William Barsan,Marilou Ching,Nina Gentile,Michael Ross,Fadi Nahab,J Donald Easton,Anthony S Kim,Karla G Zurita,Brett Cucchiara,S Claiborne Johnston

    Background and Purpose:Clopidogrel is an antiplatelet drug that is metabolized to its active form by the CYP2C19 enzyme. The CHANCE trial (Clopidogrel in High-Risk Patients With Acute Nondisabling Cerebrovascular Events) found a significant interaction between loss-of-function allele status for the CYP2C19 gene and the effect of dual antiplatelet therapy with aspirin and clopidogrel on the rate of

    更新日期:2020-06-23
  • Comparative Safety and Effectiveness of Oral Anticoagulants in Nonvalvular Atrial Fibrillation: The NAXOS Study.
    Stroke (IF 7.19) Pub Date : 2020-06-16
    Eric Van Ganse,Nicolas Danchin,Isabelle Mahé,Olivier Hanon,Flore Jacoud,Maëva Nolin,Faustine Dalon,Cinira Lefevre,François-Emery Cotté,Sabrina Gollety,Bruno Falissard,Manon Belhassen,Ph Gabriel Steg

    Background and Purpose:The effects of direct oral anticoagulants in nonvalvular atrial fibrillation should be assessed in actual conditions of use. France has near-universal healthcare coverage with a unified healthcare information system, allowing large population-based analyses. NAXOS (Evaluation of Apixaban in Stroke and Systemic Embolism Prevention in Patients With Nonvalvular Atrial Fibrillation)

    更新日期:2020-06-23
  • Comparative Effectiveness of Rivaroxaban, Apixaban, and Warfarin in Atrial Fibrillation Patients With Polypharmacy.
    Stroke (IF 7.19) Pub Date : 2020-06-10
    Amgad Mentias,Eric Heller,Mary Vaughan Sarrazin

    Background and Purpose:Comparative effectiveness and safety of oral anticoagulants in patients with atrial fibrillation and high polypharmacy are unknown.Methods:We used Medicare administrative data to evaluate patients with new atrial fibrillation diagnosis from 2015 to 2017, who initiated an oral anticoagulant within 90 days of diagnosis. Patients taking ≤3, 4 to 8, or ≥9 other prescription medications

    更新日期:2020-06-23
  • Pivotal Trial of the Neuroform Atlas Stent for Treatment of Anterior Circulation Aneurysms: One-Year Outcomes.
    Stroke (IF 7.19) Pub Date : 2020-06-17
    Osama O Zaidat,Ricardo A Hanel,Eric A Sauvageau,Amin Aghaebrahim,Eugene Lin,Ashutosh P Jadhav,Tudor G Jovin,Ahmad Khaldi,Rishi G Gupta,Andrew Johnson,Donald Frei,David Loy,Adel Malek,Gabor Toth,Adnan Siddiqui,John Reavey-Cantwell,Ajith Thomas,Steven W Hetts,Brian T Jankowitz,

    Background and Purpose:Stent-assisted coil embolization using the new generation Neuroform Atlas Stent System has shown promising safety and efficacy. The primary study results of the anterior circulation aneurysm cohort of the treatment of wide-neck, saccular, intracranial, aneurysms with the Neuroform Atlas Stent System (ATLAS trial [Safety and Effectiveness of the Treatment of Wide Neck, Saccular

    更新日期:2020-06-23
  • Assessing the Predictive Validity of Simple Dementia Risk Models in Harmonized Stroke Cohorts.
    Stroke (IF 7.19) Pub Date : 2020-06-17
    Eugene Y H Tang,Christopher I Price,Louise Robinson,Catherine Exley,David W Desmond,Sebastian Köhler,Julie Staals,Bonnie Yin Ka Lam,Adrian Wong,Vincent Mok,Regis Bordet,Anne-Marie Bordet,Thibaut Dondaine,Jessica W Lo,Perminder S Sachdev,Blossom C M Stephan,

    Background and Purpose:Stroke is associated with an increased risk of dementia. To assist in the early identification of individuals at high risk of future dementia, numerous prediction models have been developed for use in the general population. However, it is not known whether such models also provide accurate predictions among stroke patients. Therefore, the aim of this study was to determine whether

    更新日期:2020-06-23
  • Determinants of the Presence and Size of Intracranial Aneurysms in the General Population: The Rotterdam Study.
    Stroke (IF 7.19) Pub Date : 2020-06-10
    Tim Y Cras,Daniel Bos,M Arfan Ikram,Mervyn D I Vergouwen,Diederik W J Dippel,Trudy Voortman,Hieab H H Adams,Meike W Vernooij,Bob Roozenbeek

    Background and Purpose:The prevalence of unruptured intracranial aneurysms (UIAs) in the adult population is ≈3%. Rupture of an intracranial aneurysm can have devastating consequences, which emphasizes the importance of identification of potentially modifiable determinants for the presence and size of UIAs. Our aim was to study the association of a broad spectrum of potential determinants with the

    更新日期:2020-06-23
  • Common Genetic Variation Indicates Separate Causes for Periventricular and Deep White Matter Hyperintensities.
    Stroke (IF 7.19) Pub Date : 2020-06-10
    Nicola J Armstrong,Karen A Mather,Muralidharan Sargurupremraj,Maria J Knol,Rainer Malik,Claudia L Satizabal,Lisa R Yanek,Wei Wen,Vilmundur G Gudnason,Nicole D Dueker,Lloyd T Elliott,Edith Hofer,Joshua Bis,Neda Jahanshad,Shuo Li,Mark A Logue,Michelle Luciano,Markus Scholz,Albert V Smith,Stella Trompet,Dina Vojinovic,Rui Xia,Fidel Alfaro-Almagro,David Ames,Najaf Amin,Philippe Amouyel,Alexa S Beiser,Henry

    Background and Purpose:Periventricular white matter hyperintensities (WMH; PVWMH) and deep WMH (DWMH) are regional classifications of WMH and reflect proposed differences in cause. In the first study, to date, we undertook genome-wide association analyses of DWMH and PVWMH to show that these phenotypes have different genetic underpinnings.Methods:Participants were aged 45 years and older, free of stroke

    更新日期:2020-06-23
  • Incidence of Acute Ischemic Stroke With Visible Arterial Occlusion: A Population-Based Study (Dijon Stroke Registry).
    Stroke (IF 7.19) Pub Date : 2020-06-03
    Gauthier Duloquin,Mathilde Graber,Lucie Garnier,Valentin Crespy,Pierre-Olivier Comby,Laura Baptiste,Sophie Mohr,Benoit Delpont,Julien Guéniat,Christelle Blanc-Labarre,Marie Hervieu-Bègue,Guy-Victor Osseby,Maurice Giroud,Yannick Béjot

    Background and Purpose:Because of several methodological limitations, previous studies focusing on the prevalence of large vessel occlusion in ischemic stroke (IS) patients provided conflicting results. We evaluated the incidence of IS with a visible arterial occlusion using a comprehensive population-based registry.Methods:Patients with acute IS were prospectively identified among residents of Dijon

    更新日期:2020-06-23
  • Urban-Rural Inequities in Acute Stroke Care and In-Hospital Mortality
    Stroke (IF 7.19) Pub Date : 2020-06-17
    Gmerice Hammond; Alina A. Luke; Lauren Elson; Amytis Towfighi; Karen E. Joynt Maddox

    Background and Purpose:The rural-urban life-expectancy gap is widening, but underlying causes are incompletely understood. Prior studies suggest stroke care may be worse for individuals in more rural areas, and technological advancements in stroke care may disproportionately impact individuals in more rural areas. We sought to examine differences and 5-year trends in the care and outcomes of patients

    更新日期:2020-06-23
  • Frequency and Predictors of Major Bleeding in Patients With Embolic Strokes of Undetermined Source: NAVIGATE-ESUS Trial.
    Stroke (IF 7.19) Pub Date : 2020-06-10
    Robert Mikulík,Jens Eckstein,Lesly A Pearce,Hardi Mundl,Salvatore Rudilosso,Veroníca V Olavarría,Ashkan Shoamanesh,Ángel Chamorro,Joan Martí-Fàbregas,Roland Veltkamp,Şerefnur Öztürk,Turgut Tatlisumak,W Frank Peacock,Scott D Berkowitz,Stuart J Connolly,Robert G Hart

    Background and Purpose:Risks, sites, and predictors of major bleeding during antithrombotic therapies have not been well defined for patients with recent embolic stroke of undetermined source.Methods:Exploratory analysis of major bleeds defined by International Society of Thrombosis and Hemostasis criteria occurring among 7213 participants in international NAVIGATE (New Approach Rivaroxaban Inhibition

    更新日期:2020-06-23
  • Phosphatidylethanol Levels, As a Marker of Alcohol Consumption, Are Associated With Risk of Intracerebral Hemorrhage.
    Stroke (IF 7.19) Pub Date : 2020-06-16
    Kristina Johansson,Lars Johansson,Johanna Pennlert,Stefan Söderberg,Jan-Håkan Jansson,Marcus M Lind

    Background and Purpose:Previous observational studies have shown a moderately increased risk of intracerebral hemorrhage (ICH) with high self-reported alcohol consumption. However, self-reported data tend to underestimate alcohol consumption. Phosphatidylethanol is a specific biomarker reflecting alcohol intake during the last month and correlates with the amount of alcohol consumed. The present study

    更新日期:2020-06-23
  • Combining Imaging and Genetics to Predict Recurrence of Anticoagulation-Associated Intracerebral Hemorrhage.
    Stroke (IF 7.19) Pub Date : 2020-06-10
    Alessandro Biffi,Sebastian Urday,Patryk Kubiszewski,Lee Gilkerson,Padmini Sekar,Axana Rodriguez-Torres,Margaret Bettin,Andreas Charidimou,Marco Pasi,Christina Kourkoulis,Kristin Schwab,Zora DiPucchio,Tyler Behymer,Jennifer Osborne,Misty Morgan,Charles J Moomaw,Michael L James,Steven M Greenberg,Anand Viswanathan,M Edip Gurol,Bradford B Worrall,Fernando D Testai,Jacob L McCauley,Guido J Falcone,Carl

    Background and Purpose:For survivors of oral anticoagulation therapy (OAT)–associated intracerebral hemorrhage (OAT-ICH) who are at high risk for thromboembolism, the benefits of OAT resumption must be weighed against increased risk of recurrent hemorrhagic stroke. The ε2/ε4 alleles of the apolipoprotein E (APOE) gene, MRI-defined cortical superficial siderosis, and cerebral microbleeds are the most

    更新日期:2020-06-23
  • Quantitative Histogram Analysis on Intracranial Atherosclerotic Plaques: A High-Resolution Magnetic Resonance Imaging Study.
    Stroke (IF 7.19) Pub Date : 2020-06-17
    Zhang Shi,Jing Li,Ming Zhao,Wenjia Peng,Zakaria Meddings,Tao Jiang,Qi Liu,Zhongzhao Teng,Jianping Lu

    Background and Purpose:Intracranial atherosclerosis is one of the main causes of stroke, and high-resolution magnetic resonance imaging provides useful imaging biomarkers related to the risk of ischemic events. This study aims to evaluate differences in histogram features between culprit and nonculprit intracranial atherosclerosis using high-resolution magnetic resonance imaging.Methods:Two hundred

    更新日期:2020-06-23
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