Candida albicans is a semi-ubiquitous pathobiont that is known to significantly impact human health and wellbeing, causing a significant financial strain on the medical system. Due to increasing antifungal resistance, there is a growing need for novel fungal therapeutics to treat diseases caused by this fungus. The development and use of Live Biotherapeutic Products (LBPs) is an innovative and novel

In any wastewater recycling scheme, the protection of public health is of primary importance. In Australia, the public health requirements applying to the treatment of recycled water are stringent. They use the Disability-Adjusted Life Year (DALY) metric to set a level of negligible public health risk. The target maximum risk of 10–6 DALY per person per year has been adopted in Australian water recycling

At least 300 million urinary tract infections (UTIs) occur annually worldwide. Uropathogenic Escherichia coli (UPEC) are the leading cause of UTIs. The discovery of antibiotics has revolutionised modern medicine. Yet, overusing antibiotics has accelerated the emergence of antimicrobial resistance (AMR), with UPEC driving the dissemination of AMR globally. Resistance to broad-spectrum antibiotics like

Genomic viral integrations, termed endogenous viral elements (EVEs), are fragments of viruses in host chromosomes that provide information about viral evolution and could even help protect the host from infection. In the present study we examined EVEs in thirteen different Australian marsupial species to identify trends in their integration, commonality and to investigate their possible cellular function

Over the past decade, nontypeable Haemophilus influenzae (NTHi) has gained recognition as a major opportunistic pathogen of the respiratory tract that imposes a substantial global burden of disease, owing to a high rate of morbidity and ensuing complications. Further amplifying the global impact of NTHi infections is the increasing spectrum and prevalence of antibiotic resistance, leading to higher

The difficulties in performing experimental studies related to diseases of the human brain have fostered a range of disease models from highly expensive and complex animal models to simple, robust, unicellular yeast models. Yeast models have been used in numerous studies to understand Alzheimer’s disease (AD) pathogenesis and to search for drugs targeting AD. Thanks to the conservation of fundamental

Influenza B viruses circulate globally every year causing respiratory disease with significant clinical and socio-economic impacts. IBV are considered exclusive human pathogens with no established animal reservoirs, which suggests with concerted effort it may be possible to eradicate this virus from human circulation. However, this requires a deeper understanding of IBV virology and immunology and

Preterm birth (PTB) is a significant health problem globally, with an estimate of 15 million cases annually. Approximately 10% of neonates born early will die prematurely, while a subset will develop severe life-long morbidities. Unfortunately, preterm birth’s syndromic nature has evaded prevention strategies, and it continues to impose a high burden on healthcare systems and families. The role of

The gut microbiome describes the complex community of microorganisms that populate the gastrointestinal tract. Gut microbes in the large bowel utilise both dietary-derived nutrients, such as host-indigestible carbohydrates (fibre) and excess protein, host-derived nutrients (intestinal mucin), and also interact with the by-products of digestion such as bile acids. They transform these compounds into

Neisseria spp. are a transient low abundance member of the human microbiome. This species contains the very well described pathogens, Neisseria gonorrhoeae and N. meningitidis. Recent advances in molecular typing have revealed that this genus is more diverse than previously thought and that commensal species may have important roles in inhibiting the growth the pathogens. This short review summates

The extensive and on-going epidemiology studies of the SARS-CoV-2 pandemic have raised interesting observations on statins reducing COVID-19 severity. In this review, literature is analysed to examine how statins affect COVID-19 and influenza A, another pandemic respiratory virus. This information could be useful to prevent or reduce disease severity caused by respiratory viruses.

The human cervicovaginal microbiome has an important role in the health and homoeostasis of the female reproductive tract. A eubiotic microbiome is typically dominated with lactic acid producing bacteria and is categorised into five community state types. Issues arise when the microbiome becomes dysbiotic, with the microbial composition shifting to contain a greater relative abundance of strict and

The protective role of T cells in viral infection is well described. T cells generally mediate anti-viral immune responses via direct cytotoxicity and production of pro-inflammatory cytokines, by providing help to B cells and by promotion of memory responses. A fundamental step in T cell responses involves presentation of viral peptide antigens in the context of human leucocyte antigens (HLA), to the

Melioidosis is a potentially fatal bacterial infection caused by the Gram-negative bacillus, Burkholderia pseudomallei following contact with a contaminated environmental source, normally soil or water in tropical and subtropical locations. The disease spectrum varies from rapidly progressive bacteraemic infection with or without pneumonia, to focal lesions in deep soft tissues and internal organs

Otitis media (OM; middle ear infection) is the most common reason for pre-school children to visit a doctor, be prescribed antimicrobials, or undergo surgery. Recent Cochrane reviews of clinical trials have identified that antibiotics and grommet surgery are only moderately effective in treating OM, with recurrent or persistent infection observed in one-third of children. Research efforts are focusing

Helicobacter pylori colonises the gastric mucosa and is associated with various gastric diseases, including stomach cancer. At least 1 million new cases of stomach cancer cases are reported annually, and it is the fifth top cancer-killer in the world. Although H. pylori can be eradicated by a combination of antibiotics, the treatment success rate is declining due to the rise of antibiotic resistance

Since this is my first communication with you this year I will start by wishing you all a happy new year and extend my best wishes to all of you for 2021.

It is timely to assess where we are in the current SARS Coronavirus-2 pandemic. This edition of Microbiology Australia has national, and international, authorities authoring a series of papers on SARS Coronavirus 2 and related subjects. We are extremely fortunate to have papers on the overarching issues of zoonotic spread (Gartner, Selleck) and how this relates to the practicalities of our responses

Australia’s planning and preparedness for a health emergency response has served us well in the response to the COVID-19 pandemic. Despite this, rapid and agile decisions were required to manage the public health impact. In the face of uncertainty and the seemingly evolving nature of the virus, we have seen precautionary actions and outcomes beyond that articulated in planning. The timely closure of

Wastewater monitoring (WM) of SARS-CoV-2 from sewers was applied throughout the world early in the COVID-19 pandemic. Sharing of protocols and experiences in WM of SARS-CoV-2 by national and international researchers and practitioners has been vital to ensuring the sensitivity and specificity of the methods. WM has been a valuable adjunct to human clinical testing, and when positive results occur in

Aboriginal and Torres Strait Islander people may be disproportionately affected by COVID-19 and despite isolation remote communities have an increased risk of COVID-19 transmission due to overcrowding and frequent travel over long distances for family, cultural or community events. The response to an outbreak in remote settings will be logistically challenging requiring a coordinated multiagency response

Vaccines remain the main prospect for an exit strategy from the COVID-19 pandemic, and may, depending on efficacy, duration of protection and uptake, make herd immunity feasible. If herd immunity is not achievable, SARS-COV-2 will circulate long-term. There are many vaccine candidates in development and choices between vaccines that will vary in efficacy and safety. The efficacy of available vaccines

Compared with vaccines, antivirals for curbing COVID-19 (SARS-CoV-2 infection) have been developed at a much lower pace. Favipiravir has proven efficacious (in hamsters) but only at a very high dose which may not be feasible in humans. Remdesivir is the sole antiviral approved by the US FDA, but it has not been extensively evaluated for its safety. EIDD-1931 and EIDD-2801 have not been evaluated clinically

Since 2002, three zoonotic coronaviruses (CoV), SARS-CoV, MERS-CoV and SARS-CoV-2 have emerged in humans, establishing that emergence of coronaviruses from animal reservoirs represents a significant pandemic threat. SARS-CoV and MERS-CoV led to smaller epidemics with very high case fatality rates while SARS-CoV-2 resulted in a global pandemic. These zoonotic coronaviruses have their likely origins

The adaptive immune system, regulated by CD4 T cells, is essential for control of many viral infections. Endemic coronavirus infections generally occur as short-term upper respiratory tract infections which in many cases appear to be cleared before adaptive immunity is fully involved, since adaptive immunity takes approximately 1.5–2 weeks to ramp up the response to a primary infection, or approximately

In December 2019, cases of atypical pneumonia were diagnosed in hospital patients in Wuhan, Hubei province, China. The disease was characterised by a respiratory disorder of variable severity ranging from mild upper respiratory tract illness to acute respiratory distress syndrome, severe interstitial pneumonia and death. The source of the virus is yet to be confirmed but wild animals sold at wholesale

Human history has been shaped by the heavy burden of infectious disease pandemics. Yet, despite the bitter lessons learned from history, even those in living memory such as the 1918 influenza pandemic and HIV/AIDS epidemic, COVID-19 stands unique in the sudden, immense health and economic impacts to the global human population. While the costs have been great, and the long-term consequences are still

Passive anti-viral immunotherapy, including monoclonal antibodies (mAb), was identified early as a promising therapeutic avenue for COVID-19 with a rapid development pathway. This has been driven by the lack of existing effective direct acting antivirals for coronaviruses, the marginal clinical impact of remdesivir and the relative lack of efficacy of antivirals against other respiratory pathogens

The pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is distinctly different from outbreaks caused by other coronaviruses: SARS-CoV and Middle East respiratory syndrome coronavirus (MERS-CoV). The differences in the rapid transmission and severity of human coronaviruses are due to the genetic composition of the virus. SARS-CoV-2 contains genes encoding non-structural

Approximately 6 months ago, as COVID-19 became the focus of our day-to-day life, it was constantly referred to as unprecedented. In fact, this word has been used to describe almost everything that has subsequently occurred. Unprecedented of course means ‘without previous instance, never before known or experienced’. At the same time the general thrust of many headlines in the media was to cast SARS-CoV-2

I hope that this Vertical Transmission finds you and your families, friends and colleagues safe and well. Across Australia, we continue to deal with the COVID-19 pandemic, mostly through the restrictions that have been imposed to prevent transmission of the virus. Thankfully these measures have been highly effective and we have not seen the high case numbers and deaths that we see reported daily in

COVID-19, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first recognised in late 2019, with over 30 000 000 cases and over 1 000 000 deaths reported by the end of September 2020. SARS-CoV-2 infection is usually associated with fever, cough, coryza, dyspnoea, anosmia, headache and fatigue and may cause pneumonia and hypoxemia. An excessive/dysregulated inflammatory response

Bubonic plague is among the most feared diseases in human history, not only because of its death toll but also for its consequential impact on the way of life and economic endeavour of human society. Every few hundred years the advance of a pandemic has raised impotent fear, until the early 20th century when microbiological research solved the mystery of how it is transmitted to its victims, opening

The history of immunisation is full of heroes but also full of villains, and our successes are tempered by tragedies. Despite the urgent need for a vaccine against SARS-CoV-2, we should not neglect the lessons of history. These include ethical issues relating to vaccine safety, such as the possible risks of vaccine-induced enhancement witnessed with dengue vaccine in the Philippines, and how our decisions

Epidemics of paralytic poliomyelitis (polio) first emerged in the late 19th and early 20th centuries in the United States and the Scandinavian countries. They continued through the first half of the 20th century becoming global. A major epidemic occurred in Australia in 1951 but significant outbreaks were reported from the late 1930s to 1954. The poliovirus is an enterovirus that is usually transmitted

This article outlines the generally well known story of the attempt by Louis Pasteur to win the significant reward offered by the colonial governments of what would become Australia for biological control of the rabbit plague then infesting the continent. While the Pasteur bid, led by his nephew Adrien Loir, was not awarded the prize, there were significant flow-on benefits for agriculture in the colonies

The sexually transmitted infection (STI) gonorrhoea is an ancient human disease caused by the Gram-negative bacterial pathogen Neisseria gonorrhoeae. Despite decades of research focused on preventing, diagnosing, and treating gonorrhoea, it remains a major global health concern due to its high prevalence, high rates of asymptomatic cases, the severe sequelae that can result from untreated infections

The CSIRO Australian Animal Health Laboratory (AAHL) was officially opened on 1 April 1985. After that day the laboratory switched to secure mode and has operated as such ever since. AAHL was constructed to be the primary national diagnostic facility for exotic animal diseases but has expanded its role to become a national and international reference laboratory for many diseases. AAHL has supported

Tuberculosis (TB) remains an important public health challenge globally and in Australia. For the more than 10 million people who become sick with TB each year, the disease can cause immense personal and economic hardship, including loss of income and education through ill health, prolonged and arduous treatment, and stigmatisation – perpetuating a cycle of disadvantage. Past efforts to control TB

In the midst of our pandemic, when we are up to our necks in a torrent of news, opinion and speculation, it is important to step back from our personal interests in SARS-CoV-2 to consider the broader biological and social evolutionary context of what we are experiencing.

Leprosy (Hansen’s disease) was introduced to Australia in the mid-1800s and its story reflects the attitudes of the 19th and 20th centuries, with treatment including segregation, paternalism, and racism. The approaches taken within the Australian states were similar and based on isolating people affected by leprosy, as both a measure to assist the patient but, more importantly, to protect the European

From its modest beginning in 1916 with a staff of 20, CSL has grown into a major company, which now employs more than 25,000 people, operates in more than 70 countries and has a market capitalization of over A$130 billion.

Quarantine has been widely used for infection control in Australia since the time of settlement by Europeans. The history of human quarantine stations in Australia is discussed briefly here.

Towards the end of world war one, the world faced a pandemic, caused not by smallpox or bubonic plague, but by an influenza A virus. The 1918–19 influenza pandemic was possibly the worst single natural disaster of all time, infecting an estimated 500 million people, or one third of the world population and killing between 20 and 100 million people in just over one year. The impact of the virus may

In 2011, the International Health Regulations Review Committee of the WHO suggested ‘The world is ill-prepared to respond to a severe influenza pandemic or to any similarly global, sustained and threatening public-health emergency’. This was presumably partly in response to known threats that had occurred over the previous decade – Severe Acute Respiratory Syndrome (SARS) in 2003,H1N1 pandemic influenza

I hope that this Vertical Transmission finds you and your families safe and well. At the time of writing, some of you are in parts of Australia with few or no COVID-19 infections, while those of you in Victoria are in Stage 4 lockdown and dealing with the confusion, anxiety and uncertainty of this pandemic. What is clear is that the work of our dedicated epidemiologists, microbiologists, medical scientists

Imported biological products are ubiquitous necessities of modern life that can pose significant biosecurity risks to Australia. Products produced using animal material are used everywhere from enzymes in cleaning products, to cell lines and bacterial cultures used to produce vaccines and medicines. This article highlights adventitious agents of biologicals and provides an overview of the considerations

The rapid testing for Security Sensitive Biological Agents is carried out by Public Health laboratories. The commercial platforms for performing such tasks in Australia are described.

Biosecurity is a term broadly applied to the protection, control and accountability of biological agents and toxins to minimise the risk of their introduction through natural, unintentional (accidents) or deliberate processes. Biosecurity protection involves the engagement of all stakeholders including government, public health networks, industry, and scientific community. While the Commonwealth Government

As Australia’s national law enforcement agency the Australia Federal Police (AFP) plays a number of roles, broadly grouped under intelligence and investigation, in supporting a whole of government approach to responding to, and mitigating, risks from Security Sensitive Biological Agents (SSBA). The AFP is responsible for coordinating the investigation of national and transnational crimes, which includes

The novel betacoronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has caused a global pandemic unprecedented in modern times. Understanding the key features that have enabled this virus to propagate so widely in the global community is critical to current and future clinical and public health efforts. High proportions of mild disease and peak viral loads at, and likely prior

Bioterrorism is the deliberate misuse of a pathogen (virus, bacterium or other disease-causing microorganisms) or biotoxin (poisonous substance produced by an organism) to cause illness and death amongst the population. Bioterrorism and biological warfare (biowarfare) are terms often used interchangeably. However, bioterrorism is typically attributed to the politically motivated use of biological weapons

Exotic and emerging infectious diseases are emerging more frequently, and impacting more profoundly, all of humanity. Disasters risk reduction efforts over the preceding decades, culminating in the Hyogo and Sendai frameworks, have provided a roadmap for all countries to address emerging disaster related risks. Sudden onset or surprise epidemics of exotic or emerging diseases have the potential to

The aim of Australia’s Security Sensitive Biological Agents (SSBAs) Regulatory Scheme is to limit opportunities for acts of bioterrorism or criminal acts using harmful biological agents. The scheme is based on a two-tiered list of agents, of which many can cause disease in animals and thereby have the potential to significantly impact Australian agricultural industries and the economy. Laboratories

The Royal College of Pathologists (RCPA) and then RCPA Quality Assurance Programs Pty Ltd (RCPAQAP), a company independent from but aligned with the RCPA, have been producing proficiency testing programs (PTP) for infectious diseases for 52 years. This involves sending infectious disease material in surveys to over 80 countries worldwide throughout any year. The PTP panels are developed depending on

I will begin this Vertical Transmission by hoping that you and your families are all healthy and well, and coping during this very confused and frightening time. Microbiology and public health are certainly at the forefront of community and government attention at this time, and rapid solutions are being sought to deal with the SARS-CoV-2 pandemic. Unfortunately, funding for discovery research that

This issue of Microbiology Australia is on the topic of probiotics. The word ‘probiotic’ meaning ‘for life’ is derived from Latin ‘pro’ and Greek ‘bios’. According to the World Health Organization and the Food and Agriculture Organization of the United Nations, probiotics are defined as ‘live microorganisms which when administered in adequate amounts confer a health benefit on the host’1, while a very

The SARS-Cov2 has presented the world with a novel pandemic challenge requiring a rapid response. This article provides a May 2020 snapshot from Professor Paul Young, who is part of a group working with urgency on Australia’s leading COVID-19 candidate vaccine.

There is growing interest in the use of probiotics in neonates. In particular, Lactobacillus rhamnosus, L. acidophilus, Bifidobacterium breve and B. longum have been well studied. Caesarean-section (CS)-born infants often lack Lactobacillus spp. and Bifidobacterium spp., which showed increasing evidence in establishing the neonatal immune system. Furthermore, CS increases the difficulties for mothers

Faecal microbiota transplantation (FMT) is the transfer of human faeces from a healthy donor to a recipient with a disease associated with gut dysbiosis. Here we review faecal microbiota transplantation as a treatment for Clostridioides difficile infection (CDI) and other conditions including decolonisation of multiresistant organisms. Donor selection and screening, adverse events, processing, administration