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Evaluating the mode of action of perfluorooctanoic acid-induced liver tumors in male Sprague-Dawley rats using a toxicogenomic approach J Environ Sci Health C Environ Carcinog Ecotoxicol Rev (IF 1.65) Pub Date : 2024-03-18 Xilin Li, Zemin Wang, Qiangen Wu, James E. Klaunig
The mode of action (MOA) underlying perfluorooctanoic acid (PFOA)-induced liver tumors in rats is proposed to involve peroxisome proliferator-activated receptor α (PPARα) agonism. Despite clear PPA...
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Assessment of clinical chemistry and hematological parameters in female Sprague-Dawley rats following a 7-day oral exposure to three different species of Echinacea J Environ Sci Health C Environ Carcinog Ecotoxicol Rev (IF 1.65) Pub Date : 2024-03-07 Suresh K. Nagumalli, Joshua T. Salley, Jeffrey D. Carstens
Echinacea has grown in popularity due to its broad therapeutic benefits. Despite its popularity, comprehensive safety evaluations for three medicinal species are limited. In this study, female Spra...
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More about making profits or providing safe drinking water? A state-of-the-art review on sachet water contamination in Nigeria J Environ Sci Health C Environ Carcinog Ecotoxicol Rev (IF 1.65) Pub Date : 2024-03-04 Johnson C. Agbasi, Arinze Longinus Ezugwu, Michael Ekuru Omeka, Ifeanyi Adolphus Ucheana, Chiedozie Chukwuemeka Aralu, Hillary Onyeka Abugu, Johnbosco C. Egbueri
Public health concerns on surface and groundwater contamination worldwide have increased. Sachet water contamination has also raised serious concerns across many developing countries. While previou...
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Factors related to tumor response rate from TCGA three omics data—variants, expression, methylation J Environ Sci Health C Environ Carcinog Ecotoxicol Rev (IF 1.65) Pub Date : 2024-02-26 Hyung-Min Ahn, Insu Park, Chang Geun Kim, Young Kyung Ko, Jeong-An Gim
The Cancer Genome Atlas (TCGA) and its patient-derived multi-omics datasets have been the backbone of cancer research, and with novel approaches, it continues to shed new insight into the disease. ...
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Assessing the impact and mechanisms of environmental pollutants (heavy metals and pesticides) on the male reproductive system: a comprehensive review J Environ Sci Health C Environ Carcinog Ecotoxicol Rev (IF 1.65) Pub Date : 2024-01-19 Rohit Gautam, Eepsita Priyadarshini, Arbind Kumar Patel, Taruna Arora
The escalation of technological advancements, coupled with the increased use of hazardous chemicals, has emerged as a significant concern for human health. Exposure to environmental pollutants like...
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Cellular and molecular alterations in a human hepatocellular in vitro model of nonalcoholic fatty liver disease development and stratification J Environ Sci Health C Environ Carcinog Ecotoxicol Rev (IF 1.65) Pub Date : 2024-01-19 Rose A. Willett, Volodymyr P. Tryndyak, Frederick A. Beland, Igor P. Pogribny
The rapidly increasing incidence of nonalcoholic fatty liver disease (NAFLD) is a growing health crisis worldwide. If not detected early, NAFLD progression can lead to irreversible pathological sta...
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From lab to ecosystem: Understanding the ecological footprints of engineered nanoparticles J Environ Sci Health C Environ Carcinog Ecotoxicol Rev (IF 1.65) Pub Date : 2024-01-19 Shyam Sudhakar Gomte, Pratiksha Vasant Jadhav, Naga Jothi Prasath V. R, Tejas Girish Agnihotri, Aakanchha Jain
Nanotechnology has attained significant attention from researchers in past decades due to its numerous advantages, such as biocompatibility, biodegradability, and improved stability over convention...
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Heavy metal and microbial testing of selected cosmetic products in the Palestinian market J Environ Sci Health C Environ Carcinog Ecotoxicol Rev (IF 1.65) Pub Date : 2024-01-19 Murad Abualhasan, Liza Naffa, Ro’a Alarda, Baraa Zahi, Ameed Amireh, Munir Al-Atrash
Excessive and continuous use of cosmetic products containing heavy metals can lead to harmful effects. International regulations mandate limited quantities of heavy metals contamination in cosmetic...
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Concentration and sources of persistent organic pollutants within the vicinity of a scrap-iron smelting plant: Seasonal pattern and health risk assessment J Environ Sci Health C Environ Carcinog Ecotoxicol Rev (IF 1.65) Pub Date : 2024-01-19 Jamiu Adetayo Adeniran, Benjamin Toba Ogunlade, Khadijat Abdulkareem Abdulraheem, Emmanuel Toluwalope Odediran, Ayodele Sarat Atanda, Afeez Kolawole Oyeneye, Rafiu Olasunkanmi Yusuf
Polychlorinated biphenyls (PCBs) are a class of ubiquitous and significant synthetic organic chemicals that pose deleterious threats to the environment and human health. This study examined the con...
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Effects of hexavalent chromium on mitochondria and their implications in carcinogenesis J Environ Sci Health C Environ Carcinog Ecotoxicol Rev (IF 1.65) Pub Date : 2024-01-17 Anish Alur, John Phillips, Dazhong Xu
Hexavalent chromium (Cr(VI)) is a well-known occupational and environmental human carcinogen. The cellular effect of Cr(VI) is complex and often nonspecific due to its ability to modulate multiple ...
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Evaluation of antimicrobial and antioxidant activity of zinc oxide nanoparticles biosynthesized with Ziziphus spina-christi leaf extracts J Environ Sci Health C Environ Carcinog Ecotoxicol Rev (IF 1.65) Pub Date : 2023-12-18 Bushra H. Shnawa, Parwin J. Jalil, Ali Al-Ezzi, Renjbar M. Mhamedsharif, Daniyal A. Mohammed, Donia M. Biro, Mukhtar H. Ahmed
Background: Due to their simplicity, eco-friendliness, availability and non-toxicity, the greener fabrication of metal and metal oxide nanoparticles has been a highly attractive research area over ...
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A systematic review and meta-analysis of radon risk exposure from drinking water resources in Nigeria J Environ Sci Health C Environ Carcinog Ecotoxicol Rev (IF 1.65) Pub Date : 2023-12-13 Adamu Usman Mohammed, Ahmad Zaharin Aris, Mohammad Firuz Ramli, Noorain Mohd Isa, Abdullahi Suleiman Arabi, Muyiwa Michael Orosun
Elevated radon concentrations in drinking water pose an increased risk of cancer among nonsmokers. A Monte-Carlo Simulation was employed to assess the effective dose and cancer risk associated with...
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Determination of the genotoxic effects of sweeteners, mannitol and lactitol J Environ Sci Health C Environ Carcinog Ecotoxicol Rev (IF 1.65) Pub Date : 2023-12-13 Ebru Eker-Kartal, Ece Avuloglu-Yilmaz
The changes in dietary habit around the world have led to an increased use of additives in the food. The safety of food additives has been a main focus of research for many years due to the ongoing...
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Effects of SETD2 on telomere length and malignant transformation property of Met-5A after one-month crocidolite exposure J Environ Sci Health C Environ Carcinog Ecotoxicol Rev (IF 1.65) Pub Date : 2023-12-13 Min Yu, Dan Yang, Chiyun Chen, Hailing Xia
Crocidolite is a carcinogen contributing to the pathogenesis of malignant mesothelioma. This study aimed to characterize the possible telomere-related events mediating the malignant transformation ...
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Understanding the connections between climate change, air pollution, and human health in Africa: Insights from a literature review J Environ Sci Health C Environ Carcinog Ecotoxicol Rev (IF 1.65) Pub Date : 2023-12-13 Daniel A. Ayejoto, Johnson C. Agbasi, Vincent E. Nwazelibe, Johnbosco C. Egbueri, Joseph O. Alao
Climate change and air pollution are two interconnected global challenges that have profound impacts on human health. In Africa, a continent known for its rich biodiversity and diverse ecosystems, ...
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Health risk assessment of exposure to triclosan in pregnant women using Monte Carlo simulation techniques: based on biomonitoring data J Environ Sci Health C Environ Carcinog Ecotoxicol Rev (IF 1.65) Pub Date : 2023-06-27 Elham Attarian, Farzaneh Mohammadi, Karim Ebrahimpour, Malihe Moazeni, Mohammadreza Maracy, Afshin Ebrahimi, Roya Kelishadi
Abstract This study aimed to assess the triclosan (TCS) health risk in an Iranian pregnant women sample by Monte Carlo simulation (MCS). The urinary TCS of 99 women after the 28th week of pregnancy was detected by gas chromatography/mass spectrometry detector (GC/MS), and the MCS model implemented a health risk assessment. The corresponding hazard quotient (HQ) and the sensitivity analysis were calculated
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Genotoxic effects of caffeine in female mice exposed during pregnancy and lactation period and their offspring J Environ Sci Health C Environ Carcinog Ecotoxicol Rev (IF 1.65) Pub Date : 2023-05-26 Marina Lummertz Magenis, Pamela Souza de Marcos, Adriani Paganini Damiani, Anderson Ricardo Cantareli da Silva, Luiza Martins Longaretti, Ive Bahia Franca, Juliana Da Silva, Carina Rodrigues Boeck, Vanessa Moraes de Andrade
Abstract Caffeine is a widely consumed substance, and there is a discussion about its effects when ingested by women during pregnancy and lactation. We aimed to identify the genotoxic effects of caffeine in female mice that consumed it during pregnancy and lactation periods and its consequences in their offspring. Thirty-six couples of Swiss mice received water or caffeine (0.3 and 1.0 mg/mL) treatment
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Protective effects of sitagliptin on methotrexate-induced nephrotoxicity in rats J Environ Sci Health C Environ Carcinog Ecotoxicol Rev (IF 1.65) Pub Date : 2023-04-03 Leila Afkhami Fard, Hassan Malekinejad, Zeinab Esmaeilzadeh, Abbas Jafari, Mohammad Rafi Khezri, Morteza Ghasemnejad-Berenji
Abstract Methotrexate (MTX), a cytotoxic chemotherapeutic and immunosuppressant agent, is widely used in the treatment of autoimmune diseases and different types of cancers. However, its use has been limited by its life-threatening side effects, including nephrotoxicity and hepatotoxicity. The purpose of this study was to investigate the protective effect of sitagliptin on methotrexate (MTX)-induced
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Dietary exposure to thyroid disrupting chemicals: a community-based study in Canada J Environ Sci Health C Environ Carcinog Ecotoxicol Rev (IF 1.65) Pub Date : 2023-03-06 Nicole Babichuk, Atanu Sarkar, Shree Mulay, John Knight, Edward Randell
Abstract The marine ecosystem around the Island of Newfoundland is contaminated by thyroid disrupting chemicals (TDCs). Coastal inhabitants may be exposed to TDCs through consumption of contaminated local seafood products and affecting thyroid functions. The aim of this study was to explore: (1) consumption frequency of local seafood products consumed by rural residents, (2) thyroid hormones (THs)
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Toxic and carcinogenic effects of hexavalent chromium in mammalian cells in vivo and in vitro: a recent update J Environ Sci Health C Environ Carcinog Ecotoxicol Rev (IF 1.65) Pub Date : 2023-02-02 Shehnaz Islam, Sreejata Kamila, Ansuman Chattopadhyay
Abstract Chromium VI (Cr (VI)) can cross cell membranes readily and causes the formation of Cr-DNA adducts, genomic damages, elevation of reactive oxygen species (ROS) and alteration of survival signaling pathways, as evidenced by the modulation in p53 signaling pathway. Mammals, including humans are exposed to Cr, including Cr (VI), frequently through inhalation, drinking water, and food. Several
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Effect of Gene 33/Mig6/ERRFI1 on hexavalent chromium-induced transformation of human bronchial epithelial cells depends on the length of exposure J Environ Sci Health C Environ Carcinog Ecotoxicol Rev (IF 1.65) Pub Date : 2023-01-30 Cen Li, Dina Edeni, Sarah Platkin, Raymond Liu, Jiangwei Li, Maheen Hossain, Mozibur Rahman, Humayun Islam, John L. Phillips, Dazhong Xu
Abstract Hexavalent chromium (Cr(VI)) compounds are environmental and occupational lung carcinogens. The present study followed the chronic effect of Cr(VI) on the neoplastic transformation of BEAS-2B lung bronchial epithelial cells with or without deletion of Gene 33 (Mig6, EFFRI1), a multifunctional adaptor protein. We find that Gene 33-deleted cells exhibit increased anchorage-independent growth
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Association between lower-level of environmental lead exposure and reactive and proactive aggression in youth: Sex differences J Environ Sci Health C Environ Carcinog Ecotoxicol Rev (IF 1.65) Pub Date : 2023-01-20 Andrea L. Glenn, Yuli Li, Jianghong Liu
Abstract Lead exposure during childhood has been associated with a variety of negative outcomes, including antisocial/aggressive behavior. However, different subtypes of antisocial behavior have been found to have different neurobiological correlates, and it is unclear whether lead exposure is related to specific subtypes of aggressive behavior. The objective of the study was to examine relationships
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Association between polychlorinated biphenyl exposure and thyroid hormones: a systematic review and meta-analysis J Environ Sci Health C Environ Carcinog Ecotoxicol Rev (IF 1.65) Pub Date : 2022-12-14 Christine C. Little, Joshua Barlow, Mathilda Alsen, Maaike van Gerwen
Abstract Purpose: To conduct a comprehensive meta-analysis investigating the association between polychlorinated biphenyl (PCB) exposure and serum thyroid hormone levels among adults. Methods: Eleven studies met inclusion criteria for analysis following systematic search of PubMed, Embase, and Scopus databases. Of these, 7 studies measured exposure by the total sum of PCB congeners (∑PCB), 1 study
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Relationship of polycyclic aromatic hydrocarbons exposure with vascular damages among sanitation workers J Environ Sci Health C Environ Carcinog Ecotoxicol Rev (IF 1.65) Pub Date : 2022-06-06 Xuejing Lv, Jianhua Tan, Jianglu Feng, Zhilin Li, Weiran Gong, Dingguo Zhang, Hongxuan Kuang, Ruifang Fan
Abstract Chronic exposure to polycyclic aromatic hydrocarbons (PAHs) leads to a high incidence of cardiovascular diseases. To assess the effects of PAHs exposure on vascular damages in occupationally exposed populations, 196 sanitation workers were recruited. According to the differences of occupation or operation, they were divided into exposure group (n = 115) and control group (n = 81). Sixteen
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Study on the characterization of endosulfan-degrading bacterial strains isolated from contaminated rhizospheric soil J Environ Sci Health C Environ Carcinog Ecotoxicol Rev (IF 1.65) Pub Date : 2022-05-30 Vandana Singh, Shubhi Srivastava, Namrata Singh, Suchi Srivastava, Alok Lehri, Nandita Singh
Abstract In the present study, we have isolated endosulfan tolerant bacterial strains from the rhizosphere of plants growing in a pesticide-contaminated area. The tolerance capacities of these strains were tested up to 50,000 µg ml−1 of endosulfan. It was found that out of nineteen, four strains (EAG-EC-12, EAG-EC-13, EAG-EC-14, and EAG-EC-15) were capable of surviving up to 50,000 µg ml−1 endosulfan
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Longitudinal association of early childhood lead exposure and adolescent heart rate variability: influence of parental education J Environ Sci Health C Environ Carcinog Ecotoxicol Rev (IF 1.65) Pub Date : 2022-05-23 Olivia M. Halabicky, Jennifer A. Pinto-Martin, Peggy Compton, Jianghong Liu
Abstract Lead exposure has been shown to dysregulate physiological stress responses. However, few studies have investigated the effect of lead exposure on later heart rate variability (HRV), an indicator of a stress response, in large samples of children. Furthermore, the interaction between social environmental factors and lead exposure in childhood, which commonly co-occur, remains understudied.
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Environmental remediation using metals and inorganic and organic materials: a review J Environ Sci Health C Environ Carcinog Ecotoxicol Rev (IF 1.65) Pub Date : 2022-04-28 Haragobinda Srichandan, Puneet Kumar Singh, Pankaj Kumar Parhi, Pratikhya Mohanty, Tapan Kumar Adhya, Ritesh Pattnaik, Snehasish Mishra, Pranab Kumar Hota
Abstract In recent times, environmental pollution has been an alarming concern. This is increasing day-in-and-day-out, especially in the Asia-Pacific region due to the increasing population, urbanization, industrialization and inappropriate waste management measures. Pollution abatement is the need of the hour to sustain the biosphere in general and the human life in particular. A range of physical
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Review of cigars and cigar-type products as potential sources of consumer exposure to heavy metals J Environ Sci Health C Environ Carcinog Ecotoxicol Rev (IF 1.65) Pub Date : 2022-04-25 Paweł Jacek Hać, Bartłomiej Michał Cieślik, Piotr Konieczka
Abstract The popularity of cigars, growing since 1993, has not gone hand in hand with the increased interest of researchers in these products. Although the literature widely describes the harmfulness of tobacco and the content of toxic substances in tobacco products, the topic is often treated selectively as relating primarily to cigarettes and rarely extends to other products of the broadly defined
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Ascorbic acid ameliorated the sperm quality of rainbow trout (Oncorhynchus mykiss) against arsenic toxicity: Impact on oxidative stress, fertility ability and embryo development J Environ Sci Health C Environ Carcinog Ecotoxicol Rev (IF 1.65) Pub Date : 2022-04-25 Filiz Kutluyer Kocabaş, Mehmet Kocabaş, Önder Aksu, Yeliz Çakir Sahilli
Abstract Arsenic (As) is a heavy metal and aquatic pollutant and adversely impacts the reproduction of male fish. As a chain-breaking antioxidant, ascorbic acid (AA) has high water solubility and low toxicity. In this context, the current study was performed to assess the protective role of AA (1 mM) on the sperm cells of the rainbow trout (Oncorhynchus mykiss) exposed to sublethal concentrations of
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A case-control study of polychlorinated biphenyl association with metabolic and hormonal outcomes in polycystic ovary syndrome J Environ Sci Health C Environ Carcinog Ecotoxicol Rev (IF 1.65) Pub Date : 2022-03-14 Edwina Brennan, Nitya Kumar, Daniel S. Drage, Thomas K. Cunningham, Thozhukat Sathyapalan, Jochen F. Mueller, Stephen L. Atkin
Abstract Polychlorinated biphenyls (PCBs) are a class of environmental pollutants with a long half-life that sequester in fat. Women with polycystic ovarian syndrome (PCOS) may represent a sensitive subgroup to endogenous exposure to PCBs because of associated weight gain. Seven PCB congeners were compared in age, ethnicity, and BMI matched women with (n = 29) and without (n = 30) PCOS and related
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The expression of Phase II drug-metabolizing enzymes in human B-lymphoblastoid TK6 cells J Environ Sci Health C Environ Carcinog Ecotoxicol Rev (IF 1.65) Pub Date : 2022-03-11 Xilin Li, Yuxi Li, Kylie G. Ning, Si Chen, Lei Guo, Jessica A. Bonzo, Nan Mei
Abstract In vitro genotoxicity testing plays an important role in chemical risk assessment. The human B-lymphoblastoid cell line TK6 is widely used as a standard cell line for regulatory safety evaluations. Like many other mammalian cell lines, TK6 cells have limited metabolic capacity; therefore, usually require a source of exogenous metabolic activation for use in genotoxicity testing. Previously
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Degradation of isoniazid by anodic oxidation and subcritical water oxidation methods: Application of Box–Behnken design J Environ Sci Health C Environ Carcinog Ecotoxicol Rev (IF 1.65) Pub Date : 2022-01-24 Özkan Görmez, Selda Doğan Çalhan, Belgin Gözmen
Abstract Pharmaceutical compounds released into the aquatic environment are known to cause toxic effects on the environment. Isoniazid is widely used in the treatment of tuberculosis and is, therefore, frequently encountered in environmental waters. In this study, the degradation of isoniazid was investigated by anodic oxidation and subcritical water oxidation method which are members of Advanced Oxidation
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In vivo and in silico approaches to assess surface water genotoxicity from Tocantins River, in the cities of Porto Nacional and Palmas, Brazil J Environ Sci Health C Environ Carcinog Ecotoxicol Rev (IF 1.65) Pub Date : 2022-01-04 José Lopes Soares Neto, Raíne Fogliati de Carli, Mauricio Lehmann, Cláudia Telles de Souza, Liana Appel Boufleur Niekraszewicz, Johnny Ferraz Dias, Fernanda Rabaioli da Silva, Juliana da Silva, Rafael Rodrigues Dihl
Abstract The main environmental problem in urban areas, especially in Brazil, is the discharge of untreated sewage. The in vivo Drosophila melanogaster Somatic Mutation and Recombination Test (SMART) was used to assess the genotoxicity of surface waters from three different sites in the Tocantins River, Brazil. The in silico approach was used to search for known and predicted interactions between environmental
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Bystander effect of ultraviolet A radiation protects A375 melanoma cells by induction of antioxidant defense J Environ Sci Health C Environ Carcinog Ecotoxicol Rev (IF 1.65) Pub Date : 2021-12-13 Surajit Hansda, Rita Ghosh
Abstract Ultraviolet (UV) irradiated cells release factors that result in varied responses by non-irradiated cells via bystander effects (BE). The UV-BE is dependent on the cell types involved and on the wavelength of the radiation. Using conditioned medium from UVA-irradiated A375 human melanoma cells (UVA-CM), UVA-bystander response was evaluated on the viability of naïve A375 cells. UVA-CM treatment
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Ecotoxicological effects of dietary titanium dioxide nanoparticles on metabolic and biochemical parameters of model organism Galleria mellonella (Lepidoptera: Pyralidae) J Environ Sci Health C Environ Carcinog Ecotoxicol Rev (IF 1.65) Pub Date : 2021-09-09 Serkan Sugeçti, Benay Tunçsoy, Ender Büyükgüzel, Pınar Özalp, Kemal Büyükgüzel
Abstract Nanoparticles (NPs) are now being used in many industrial activities, such as mining, paint and glass industries. The frequent industrial use of NPs contributes to environmental pollution and may cause cellular and oxidative damage in native organisms. In this study, the toxic effects of titanium dioxide nanoparticles (TiO2 NPs) were investigated using Galleria mellonella larvae as a model
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Applications of electron spin resonance spectroscopy in photoinduced nanomaterial charge separation and reactive oxygen species generation J Environ Sci Health C Environ Carcinog Ecotoxicol Rev (IF 1.65) Pub Date : 2021-09-01 Xiumei Jiang, Mary D. Boudreau, Peter P. Fu, Jun-Jie Yin
Abstract Nano-metals, nano-metal oxides, and carbon-based nanomaterials exhibit superior solar-to-chemical/photo-electron transfer properties and are potential candidates for environmental remediations and energy transfer. Recent research effort focuses on enhancing the efficiency of photoinduced electron-hole separation to improve energy transfer in catalytic reactions. Electron spin resonance (ESR)
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Glyphosate disrupts sperm quality and induced DNA damage of rainbow trout (Oncorhynchus mykiss) sperm J Environ Sci Health C Environ Carcinog Ecotoxicol Rev (IF 1.65) Pub Date : 2021-09-01 Ayşe Akça, Mehmet Kocabaş, Filiz Kutluyer
Abstract As a widespread pollutant, glyphosate (GLY) adversely affects the aquatic environment and can impair the reproductive ability and functions of fish. The purpose of the current study was to assess in vitro effect of GLY on rainbow trout (Oncorhynchus mykiss) sperm cells. The sperm cells were exposed to different GLY concentrations (2.5, 5, 10 mg/L). Sperm motility parameters were analyzed with
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Sub-acute exposure to Sudan IV-adulterated palm oil induces oxidative stress and represses the expression of Nrf2 and antioxidant genes in male albino rats J Environ Sci Health C Environ Carcinog Ecotoxicol Rev (IF 1.65) Pub Date : 2021-08-24 Ofem E. Eteng, Ceaser A. Moses, Emmanuel I. Ugwor, Joe E. Enobong, Adio J. Akamo, Dorcas I. Akinloye, Irene O. Sadiku, Arikpo Iwara, Eyong Ubana
Abstract This study investigated the effects of Sudan IV dye (S4D) on antioxidant biomarkers using palm oil adulterated with S4D. Thirty male albino rats were grouped into five (n = 6); Normal control, palm oil (PO), PO + S4D (100 mg/kg), PO + S4D (250 mg/kg), and S4D (250 mg/kg) for 21 days. Oxidative stress biomarkers were assessed in the serum, liver, and kidneys. Exposure to S4D (alone and in adulterated
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Metabolism of carcinogenic pyrrolizidine alkaloids and pyrrolizidine alkaloid N-oxides by rat primary hepatocytes generate the same characteristic DHP-DNA adducts J Environ Sci Health C Environ Carcinog Ecotoxicol Rev (IF 1.65) Pub Date : 2021-08-23 Xiaobo He, Qingsu Xia, Qiang Shi, Peter P. Fu
Abstract We recently established a genotoxic mechanism mediated by a set of (±)-6,7-dihydro-7-hydroxy-1-hydroxymethyl-5H-pyrrolizine (DHP)-DNA adducts, which lead to pyrrolizidine alkaloid (PA)-induced liver tumor initiation. This mechanism is involved in the metabolism of a series of carcinogenic PAs and PA N-oxides in rats in vivo and in vitro. There is a correlation between the order of liver tumor
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Effect of fluoride on bone and growth plate cartilage J Environ Sci Health C Environ Carcinog Ecotoxicol Rev (IF 1.65) Pub Date : 2021-08-23 Mercedes Lombarte, Brenda L. Fina, Lucas R. Brun, Stella Maris Roma, Alfredo Rigalli, Di Loreto V E
Abstract The use of fluoride (F) for therapeutic purposes is controversial and its toxicity is a health problem. The aim of this study was to evaluate the effect of F on endochondral ossification in growing rats. Twenty-four rats of 21 days were divided into 4 groups which received 0, 20, 40 or 80 μmol F/100 g body weight/day for 30 days, through an orogastric tube. Histological evaluation of growth
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Protective role of Spirulina platensis against glyphosate induced toxicity in marine mussel Mytilus galloprovincialis J Environ Sci Health C Environ Carcinog Ecotoxicol Rev (IF 1.65) Pub Date : 2021-08-04 Ouarghi Wided, Khazri Abdelhafidh, Mezni Ali, Samir Touaylia
Abstract Glyphosate is a toxic environmental pollutant that has the ability to induce biochemical and physiological alterations in living organisms. Several studies have focused on the research of protective techniques against the stress induced by this contaminant. In this context, we studied the protective effect of Spirulina against the disturbances induced by glyphosate. A biomarker approach was
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miR-30d-5p represses the proliferation, migration, and invasion of lung squamous cell carcinoma via targeting DBF4 J Environ Sci Health C Environ Carcinog Ecotoxicol Rev (IF 1.65) Pub Date : 2021-06-24 Yitian Qi, Yi Hou, Liangchen Qi
Abstract Objective This study aims to explore the mechanism of miR-30d-5p in regulating the development of lung squamous cell carcinoma (LUSC) via targeting DBF4. Methods Bioinformatics methods were employed to analyze the differentially expressed genes in LUSC tissue microarray. qRT-PCR was employed to detect the expression of miR-30d-5p and DBF4 mRNA in normal human bronchial epithelial cells and
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Trace elements exposure and risk in age-related eye diseases: a systematic review of epidemiological evidence J Environ Sci Health C Environ Carcinog Ecotoxicol Rev (IF 1.65) Pub Date : 2021-06-11 Onyinyechi Bede-Ojimadu, Chinna N. Orish, Beatrice Bocca, Flavia Ruggieri, Chiara Frazzoli, Orish E. Orisakwe
Abstract This systematic review aimed to evaluate existing evidence on the associations between trace elements exposure and age-related eye diseases. PubMed and Google scholar databases were searched for epidemiological and postmortem studies on the relationship between exposure to trace elements and Age-related eye diseases such as age-related macular degeneration (AMD), cataract, glaucoma and diabetic
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Effect of urinary pH upon the renal toxicity of melamine and cyanuric acid J Environ Sci Health C Environ Carcinog Ecotoxicol Rev (IF 1.65) Pub Date : 2021-07-13
Abstract In 2007, dietary exposure to “scrap melamine’ resulted in the death of a large number of cats and dogs, which was attributed to the formation of melamine cyanurate crystals in their kidneys. In this study, we investigated if changes in urinary pH could diminish the renal toxicity associated with exposure to combinations of melamine and cyanuric acid. Female Sprague-Dawley rats were treated
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A descriptor-based analysis to highlight the mechanistic rationale of mutagenicity J Environ Sci Health C Environ Carcinog Ecotoxicol Rev (IF 1.65) Pub Date : 2021-05-06 Domenico Gadaleta, Emilio Benfenati
Abstract Cancer is a main concern for human health and there is a need of alternative methodologies to rapidly screen large quantitative of compounds that may represent a toxicological risk. Here a statistical analyses is performed on a benchmark database of experimental Ames data to identify chemical descriptors discriminating mutagens and non-mutagens. A total of 53 activating and deactivating modulators
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Manned space travel: from a race between nations to a race against the environmental stressors beyond earth J Environ Sci Health C Environ Carcinog Ecotoxicol Rev (IF 1.65) Pub Date : 2021-04-27 Marjan Boerma, Igor Koturbash
(2021). Manned space travel: from a race between nations to a race against the environmental stressors beyond earth. Journal of Environmental Science and Health, Part C: Vol. 39, Overcoming the challenges of space environment; Guest Editor: Marjan Boerma; Igor Koturbash, pp. 109-112.
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Everything you wanted to know about space radiation but were afraid to ask J Environ Sci Health C Environ Carcinog Ecotoxicol Rev (IF 1.65) Pub Date : 2021-04-27 Jeffery Chancellor, Craig Nowadly, Jacqueline Williams, Serena Aunon-Chancellor, Megan Chesal, Jayme Looper, Wayne Newhauser
Abstract The space radiation environment is a complex combination of fast-moving ions derived from all atomic species found in the periodic table. The energy spectrum of each ion species varies widely but is prominently in the range of 400–600 MeV/n. The large dynamic range in ion energy is difficult to simulate in ground-based radiobiology experiments. Most ground-based irradiations with mono-energetic
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The individual and combined effects of spaceflight radiation and microgravity on biologic systems and functional outcomes J Environ Sci Health C Environ Carcinog Ecotoxicol Rev (IF 1.65) Pub Date : 2021-04-27 Jeffrey S. Willey, Richard A. Britten, Elizabeth Blaber, Candice G.T. Tahimic, Jeffrey Chancellor, Marie Mortreux, Larry D. Sanford, Angela J. Kubik, Michael D. Delp, Xiao Wen Mao
Abstract Both microgravity and radiation exposure in the spaceflight environment have been identified as hazards to astronaut health and performance. Substantial study has been focused on understanding the biology and risks associated with prolonged exposure to microgravity, and the hazards presented by radiation from galactic cosmic rays (GCR) and solar particle events (SPEs) outside of low earth
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Consequences of space radiation on the brain and cardiovascular system J Environ Sci Health C Environ Carcinog Ecotoxicol Rev (IF 1.65) Pub Date : 2021-04-27 Catherine M. Davis, Antiño R. Allen, Dawn E. Bowles
Abstract Staying longer in outer space will inevitably increase the health risks of astronauts due to the exposures to galactic cosmic rays and solar particle events. Exposure may pose a significant hazard to space flight crews not only during the mission but also later, when slow-developing adverse effects could finally become apparent. The body of literature examining ground-based outcomes in response
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Longitudinal metabolic alterations in plasma of rats exposed to low doses of high linear energy transfer radiation J Environ Sci Health C Environ Carcinog Ecotoxicol Rev (IF 1.65) Pub Date : 2021-04-27 Tixieanna Dissmore, Andrew G DeMarco, Meth Jayatilake, Michael Girgis, Shivani Bansal, Yaoxiang Li, Khyati Mehta, Vijayalakshmi Sridharan, Kirandeep Gill, Sunil Bansal, John B Tyburski, Amrita K Cheema
Abstract Astronauts embarking on deep space missions are at high risk of long-term exposure to low doses of high linear energy transfer (LET) radiation, which can contribute to the development of cancer and multiple degenerative diseases. However, long term effects of exposure to low doses of high LET radiation in plasma metabolite profiles have not been elucidated. We utilized an untargeted metabolomics
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Short-term metabolic disruptions in urine of mouse models following exposure to low doses of oxygen ion radiation J Environ Sci Health C Environ Carcinog Ecotoxicol Rev (IF 1.65) Pub Date : 2021-04-27 Michael Girgis, Yaoxiang Li, Meth Jayatilake, Kirandeep Gill, Sirao Wang, Kepher Makambi, Vijayalakshmi Sridharan, Amrita K Cheema
Abstract Molecular alterations as a result of exposure to low doses of high linear energy transfer (LET) radiation can have deleterious short- and long-term consequences on crew members embarking on long distance space missions. Oxygen ions (16O) are among the high LET charged particles that make up the radiation environment inside a vehicle in deep space. We used mass spectrometry-based metabolomics
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Mitochondrial uncoupling protein 2 is regulated through heterogeneous nuclear ribonucleoprotein K in lead exposure models J Environ Sci Health C Environ Carcinog Ecotoxicol Rev (IF 1.65) Pub Date : 2021-02-12 Gaochun Zhu, Qian Zhu, Wei Zhang, Chen Hui, Yuwen Li, Meiyuan Yang, Shimin Pang, Yaobing Li, Guoyong Xue, Hongping Chen
Abstract Synaptic plasticity plays an important role in learning and memory in the developing hippocampus. However, the precise molecular mechanism in lead exposure models remains to be studied. UCP2, an inner mitochondrial anion carrier, regulates synaptic plasticity through uncoupling neurons. And hnRNP K, an RNA binding protein, plays a role in modulating the expression of transcripts coding synaptic
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Three dimensional graphene materials doped with heteroatoms for extraction and adsorption of environmental pollutants in wastewater J Environ Sci Health C Environ Carcinog Ecotoxicol Rev (IF 1.65) Pub Date : 2021-02-07 Zhiyong Guo, Yufeng Feng, Chen Zhang, Guihua Huang, Jinxin Chi, Qiuhong Yao, Guofeng Zhang, Xi Chen
Abstract Environmental pollution by heavy metal ions, organic pollutants, oils, pesticides or dyes is a ubiquitous problem adversely affecting human health and environmental ecology. Development and application novel adsorbents in full-scale treatment systems with effectiveness properties could effective ways to facilitate the extraction and adsorption of environment pollutants from wastewater. Graphene
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Molecular toxicology and carcinogenesis of fumonisins: a review J Environ Sci Health C Environ Carcinog Ecotoxicol Rev (IF 1.65) Pub Date : 2021-02-07 Ruth Nabwire Wangia-Dixon, Kizito Nishimwe
Abstract Fumonisins, discovered in 1988 are a group of naturally occurring toxins produced by fusarium pathogenic fungi. Besides their presence in animal feeds, contamination of human foods such as corn, millet, oats, rye, barley, wheat and their products are widespread. Exposure to fumonisins results in species and organ specific toxicities including neurological disorders among equids, pulmonary
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Characterization of cytochrome P450s (CYP)-overexpressing HepG2 cells for assessing drug and chemical-induced liver toxicity J Environ Sci Health C Environ Carcinog Ecotoxicol Rev (IF 1.65) Pub Date : 2021-02-12 Si Chen, Qiangen Wu, Xilin Li, Dongying Li, Nan Mei, Baitang Ning, Montserrat Puig, Zhen Ren, William H. Tolleson, Lei Guo
Abstract Hepatic metabolism catalyzed by the cytochrome P450 (CYP) superfamily affects liver toxicity associated with exposures to natural compounds and xenobiotic agents. Previously we generated a battery of HepG2-derived stable cell lines that individually express 14 CYPs (1A1, 1A2, 1B1, 2A6, 2B6, 2C8, 2C9, 2C18, 2C19, 2D6, 2E1, 3A4, 3A5, and 3A7). In this study, we comprehensively characterized
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Is low-level metal exposure related to testicular cancer? J Environ Sci Health C Environ Carcinog Ecotoxicol Rev (IF 1.65) Pub Date : 2021-02-12 Blanka Tariba Lovaković, Tanja Živković Semren, Toni Safner, Marija Gamulin, Majana Soče, Alica Pizent
Abstract Disruption of element homeostasis may contribute to increased susceptibility of men to cancer development. Whether environmental low-level metal exposure could contribute to the pathogenesis of testicular cancer is unknown. Comparison of the level of 18 elements in whole blood, serum and urine and parameters of oxidative stress/antioxidant status between men with testicular germ cell tumors
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Molecular toxicology and carcinogenesis of fumonisins: a review J Environ Sci Health C Environ Carcinog Ecotoxicol Rev (IF 1.65) Pub Date : 2021-02-07 Ruth Nabwire Wangia-Dixon, Kizito Nishimwe
Abstract Fumonisins, discovered in 1988 are a group of naturally occurring toxins produced by fusarium pathogenic fungi. Besides their presence in animal feeds, contamination of human foods such as corn, millet, oats, rye, barley, wheat and their products are widespread. Exposure to fumonisins results in species and organ specific toxicities including neurological disorders among equids, pulmonary
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Three dimensional graphene materials doped with heteroatoms for extraction and adsorption of environmental pollutants in wastewater J Environ Sci Health C Environ Carcinog Ecotoxicol Rev (IF 1.65) Pub Date : 2021-02-07 Zhiyong Guo, Yufeng Feng, Chen Zhang, Guihua Huang, Jinxin Chi, Qiuhong Yao, Guofeng Zhang, Xi Chen
Abstract Environmental pollution by heavy metal ions, organic pollutants, oils, pesticides or dyes is a ubiquitous problem adversely affecting human health and environmental ecology. Development and application novel adsorbents in full-scale treatment systems with effectiveness properties could effective ways to facilitate the extraction and adsorption of environment pollutants from wastewater. Graphene
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Photo-enhanced enzyme-like activities of BiOBr/PtRu hybrid nanostructures J Environ Sci Health C Environ Carcinog Ecotoxicol Rev (IF 1.65) Pub Date : 2020-12-26 Chuang Liu, Yingying Yan, Yuanyang Mao, Weiwei He
Abstract The combination of semiconductor and metal nanocomponents represents an effective way for design of photocatalysts with high efficiency. It is expected that this strategy can be applied to design photo-regulated nanozymes. To prove this concept, BiOBr/PtRu hybrid nanostructures have been fabricated by depositing PtRu nanoparticles on BiOBr nanosheets through a templating co-reduction method
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Antibody-based detection of lysine modification of hepatic protein in mice treated with retrorsine J Environ Sci Health C Environ Carcinog Ecotoxicol Rev (IF 1.65) Pub Date : 2020-12-31 Ting Cheng, Weiwei Li, Xiaojing Yang, Huali Wang, Fan Zhang, Na Li, Ge Lin, Jiang Zheng
Abstract Many pyrrolizidine alkaloids (PAs), an important class of natural products, are hepatotoxic and carcinogenic. Increased attention has been paid to PA poisoning cases worldwide. Generally, most PAs themselves are not toxic. However, reactive intermediates formed from PAs by metabolic oxidation have been linked to toxicity and carcinogenesis. PAs themselves are generally not toxic, and their