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Comparison of pathologist review protocols for cytologic detection of prostatic and urothelial carcinomas in canines: a bi‐institutional retrospective study of 298 cases Vet. Comp. Oncol. (IF 1.749) Pub Date : 2021-01-24 Camille A. McAloney; Samantha J. M. Evans; Jessica A. Hokamp; Maxey L. Wellman; Mary E. White
Urothelial carcinoma, also known as transitional cell carcinoma, is the most common primary bladder tumor in dogs, and can also involve the prostate gland. Cytology is a common diagnostic tool utilized for dogs with bladder or prostate gland lesions. The objectives of this retrospective study were to compare the sensitivity and specificity of cytologic evaluation for urothelial or prostatic carcinoma
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Evaluation of the neoplastic infiltration of the skin overlying canine subcutaneous soft tissue sarcomas: An explorative study Vet. Comp. Oncol. (IF 1.749) Pub Date : 2021-01-09 Sara Del Magno; Emanuela Morello; Selina Iussich; Cecilia Gola; Boris Dalpozzo; Maurizio Annoni; Marina Martano; Federico Massari; Davide Giacobino; Lisa Adele Piras; Damiano Stefanello; Paolo Buracco
Studies regarding the neoplastic infiltration of the skin overlying canine subcutaneous soft tissue sarcoma (sSTS) are lacking. In case of the absence of tumor infiltration, there would be the possibility of leaving this unaffected skin in place, thus simplifying surgery. The aim of the study was to investigate whether the skin overlying sSTSs is infiltrated by neoplastic cells. Dogs with sSTSs treated
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Total laryngectomy and permanent tracheostomy in 6 dogs Vet. Comp. Oncol. (IF 1.749) Pub Date : 2021-01-18 Brad M. Matz; Ralph A. Henderson; Stephanie S. Lindley; Annette N. Smith
The objective of this report is to describe the surgical technique for total laryngectomy and outcome in 6 dogs. Laryngeal cancer is an uncommon and challenging clinical problem. Total laryngectomy can provide local disease control but is uncommonly performed. Detailed procedural descriptions are limited and similarly limited information is available regarding patient outcome.
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Determining agreement between preoperative computed tomography lymphography and indocyanine green near infrared fluorescence intraoperative imaging for sentinel lymph node mapping in dogs with oral tumours Vet. Comp. Oncol. (IF 1.749) Pub Date : 2021-01-05 Jennifer Wan; Michelle L. Oblak; Ann Ram; Ameet Singh; Stephanie Nykamp
Lymphatic drainage from the head and neck is variable with significant crossover, therefore sentinel lymph node (SLN) mapping can help ensure the appropriate lymph node(s) are sampled. To improve sensitivity, SLN mapping utilizing multiple modalities and a combination of preoperative computed tomography lymphography (CTL) and intraoperative near infrared fluorescence imaging (NIRF) with indocyanine
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Feline and canine Merkel cell carcinoma: A case series and discussion on cellular origin Vet. Comp. Oncol. (IF 1.749) Pub Date : 2020-12-29 Francine E. M. M. van der Steen; Guy C. M. Grinwis; Erik A. W. S. Weerts; Erik Teske
Merkel cell carcinoma (MCC) is in humans and cats a malignant cutaneous neuroendocrine carcinoma, whereas in dogs it possibly has a more benign behaviour. It may be cytologically confused with round cell tumours such as lymphoma because of its striking cytomorphologic similarity. Although MCC is considered to arise from Merkel cells, recent findings indicated that primitive (epi‐)dermal stem cells
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The effect of cannabidiol on canine neoplastic cell proliferation and mitogen‐activated protein kinase activation during autophagy and apoptosis Vet. Comp. Oncol. (IF 1.749) Pub Date : 2020-11-28 Joshua G. Henry; Gregory Shoemaker; Jennifer M. Prieto; Many Beth Hannon; Joseph J. Wakshlag
Low tetrahydrocannabinol Cannabis sativa products, also known as hemp products, have become widely available and their use in veterinary patients has become increasingly popular. Despite prevalence of use, the veterinary literature is lacking and evidence‐based resource for cannabinoid efficacy. The most prevailing cannabinoid found in hemp is cannabidiolic acid (CBDA) and becomes cannabidiol (CBD)
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Plasma 25‐hydroxyvitamin D and the inflammatory response in canine cancer Vet. Comp. Oncol. (IF 1.749) Pub Date : 2020-11-22 Nicole Weidner; J. Anthony Mutsaers; J. Paul Woods; A. Geoff Wood; Julie Bayle; Adronie Verbrugghe
Decreased circulating 25‐hydroxyvitamin D (25[OH]D) and increased inflammatory marker concentrations have been reported separately in canine cancer. Correlations between the two exist in humans, but little work has examined links in dogs. This study aimed to determine plasma 25(OH)D and inflammatory marker concentrations in healthy dogs and dogs with cancer and to assess correlations in each group
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Evaluation of prognostic impact of pre‐treatment neutrophil to lymphocyte and lymphocyte to monocyte ratios in dogs with oral malignant melanoma treated with surgery and adjuvant CSPG4‐antigen electrovaccination: an explorative study Vet. Comp. Oncol. (IF 1.749) Pub Date : 2021-01-14 M. Camerino; D. Giacobino; S. Iussich; U. Ala; F. Riccardo; F. Cavallo; M. Martano; E. Morello; P. Buracco
The role of systemic inflammation in cancer’s progression has been widely investigated, especially in melanoma in humans. Pre‐treatment leukocytes count and ratios play a recognized prognostic role in several types of malignancies, but no information is available regarding canine oral malignant melanoma (COMM). The purpose of this explorative retrospective study was to investigate the prognostic impact
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Outcome and prognosis for canine appendicular osteosarcoma treated with stereotactic body radiation therapy in 123 dogs Vet. Comp. Oncol. (IF 1.749) Pub Date : 2021-01-05 Tiffany Wormhoudt Martin; Lynn Griffin; James Custis; Stewart D. Ryan; Mary Lafferty; Mary‐Keara Boss; Daniel Regan; Sangeeta Rao; Del Leary; Stephen J. Withrow; Susan M. LaRue
Canine appendicular osteosarcoma is commonly treated with limb amputation; however, limb‐sparing options are frequently desired or necessary for a subset of patients. We evaluated 123 patients and 130 sites treated with stereotactic body radiation therapy (SBRT). Eighty‐two out of 98 dogs (84%) had maximum lameness improvement at a median of 3 weeks for a median of 6 months duration. Histopathologic
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The selective inhibitor of nuclear export (SINE) verdinexor exhibits biologic activity against canine osteosarcoma cell lines Vet. Comp. Oncol. (IF 1.749) Pub Date : 2021-01-13 Justin T. Breitbach; Darian S. Louke; Savannah J. Tobin; Mauria R. Watts; Alexander E. Davies; Joelle M. Fenger
Verdinexor (KPT‐335) is a novel orally bioavailable Selective Inhibitor of Nuclear Export (SINE) compound that inhibits the function of the nuclear export protein Exportin 1 (XPO1/CRM1). In the present study, we sought to characterize the expression of XPO1 in primary canine osteosarcoma (OS) tumor samples, OS cell lines and normal osteoblasts and evaluate the in vitro activity of verdinexor alone
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Veterinary Cooperative Oncology Group ‐ Common Terminology Criteria for Adverse Events (VCOG‐CTCAE v2) Following Investigational Therapy in Dogs and Cats Vet. Comp. Oncol. (IF 1.749) Pub Date : 2021-01-11 Le Blanc AK; M. Atherton; R. T. Bentley; C. E. Boudreau; J. H. Burton; K. M. Curran; S. Dow; M. A. Giuffrida; H. B. Kellihan; N. J. Mason; M. L. Oblak; L. E. Selmic; K. A. Selting; A. Singh; S. Tjostheim; D. M. Vail; K. M. Weishaar; E. P. Berger; J. H. Rossmeisl; C. Mazcko
The updated VCOG‐CTCAE v2 guidelines contain several important updates and additions since the last update (v1.1) was released in 2011 and published within Veterinary and Comparative Oncology in 2016. As the Veterinary Cooperative Oncology Group (VCOG) is no longer an active entity, the original authors and contributors to the VCOG‐CTCAE v1.0 and v1.1 were consulted for input, and additional co‐authors
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Prognostic impact of clinical, haematological, and histopathological variables in 102 canine cutaneous perivascular wall tumours Vet. Comp. Oncol. (IF 1.749) Pub Date : 2021-01-02 Lavinia E. Chiti; Roberta Ferrari; Patrizia Boracchi; Emanuela Morello; Laura Marconato; Paola Roccabianca; Giancarlo Avallone; Selina Iussich; Alessia Giordano; Erica I. Ferraris; Chiara Agnoli; Francesco Dondi; Davide Giacobino; Francesco Godizzi; Damiano Stefanello
Identification of prognostic factors for perivascular wall tumours (PWTs) is desirable to accurately predict prognosis and guide treatment. 100 and two dogs with surgically excised PWTs without distant metastasis were retrospectively enrolled in this multi‐institutional study, and the impact of pre‐treatment leukocyte parameters, clinical and histopathological variables on local recurrence (LR) and
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Reducing margins for abdominopelvic tumours in dogs: Impact on dose‐coverage and normal tissue complication probability Vet. Comp. Oncol. (IF 1.749) Pub Date : 2020-12-28 Valeria Meier; Chris Staudinger; Stephan Radonic; Jürgen Besserer; Uwe Schneider; Linda Walsh; Carla Rohrer Bley
Image‐guided, intensity modulated radiation therapy (IG‐IMRT) reduces dose to pelvic organs at risk without losing dose coverage to the planning target volume (PTV) and might permit margin reductions potentially resulting in lower toxicity. Appropriate PTV margins have not been established for IG‐IMRT in abdominopelvic tumours in dogs, and herein we explore if our usual PTV 5 mm margin can be reduced
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Peripheral blood cell ratios as prognostic factors in canine diffuse large B‐cell lymphoma treated with CHOP protocol Vet. Comp. Oncol. (IF 1.749) Pub Date : 2020-11-28 Joaquim Henriques; Ricardo Felisberto; Fernando Constantino‐Casas; José Cabeçadas; Jane Dobson
Diffuse large B‐cell lymphoma (DLBCL) is the most common haematopoietic tumour in dogs and recognized as clinical model for its human counterpart. Recently, neutrophil‐to‐lymphocyte (NLR) and lymphocyte‐to‐monocyte (LMR) ratios have been shown to predict time‐to‐progression (TTP) and lymphoma‐specific survival (LSS) in dogs with DLBCL treated with CHOP‐based chemotherapy. We retrospectively evaluated
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Prevalence and potentially prognostic value of C‐circles associated with alternative lengthening of telomeres in canine appendicular osteosarcoma Vet. Comp. Oncol. (IF 1.749) Pub Date : 2020-11-19 Ludmila Bicanova; Theresa Kreilmeier‐Berger; Martin Reifinger; Klaus Holzmann; Miriam Kleiter
Alternative lengthening of telomeres (ALT) is a telomerase‐independent telomere maintenance mechanism (TMM) with high prevalence in human osteosarcomas but remains unknown in canine osteosarcomas. The aim of this study was to evaluate the prevalence of ALT by detection of extra‐chromosomal circles of telomeric DNA and to assess clinical outcome in canine patients with spontaneous occurring appendicular
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Hormone receptor expression, clinical and histopathological analysis in feline injection site sarcomas Vet. Comp. Oncol. (IF 1.749) Pub Date : 2020-11-19 Virgínia V. Zanuncio; Lissandro G. Conceição; Fabrícia H. Loures; Geovanni D. Cassali; Kelvin Rocha; Bruna M. Lima
Feline injection site sarcomas (FISS) are aggressive, with high recurrence and rarely metastasising. The objective of this study was to evaluate, by immunohistochemistry, the expression of oestrogen (ER) and progesterone (PR) receptors in FISS and correlate them with clinical and histopathological aspects. This was a retrospective study with 51 cases of FISS. Immunohistochemistry was performed to detect
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Are B‐symptoms more reliable prognostic indicators than substage in canine nodal diffuse large B‐cell lymphoma Vet. Comp. Oncol. (IF 1.749) Pub Date : 2020-11-02 Ondřej Škor; Ludmila Bicanová; Birgitt Wolfesberger; Andrea Fuchs‐Baumgartinger; Barbara Ruetgen; Marie Štěrbová; Ilse Schwendenwein; Miriam Kleiter
In humans B‐symptoms refer to systemic symptoms of lymphoma such as fever, weight loss, and night sweats and influence the prognosis of patients. In canine lymphoma, substage B is used to describe any clinical sign observed. Aim of the retrospective study was to compare the prognostic value of substage B with B‐symptoms to predict treatment response and survival in canine nodal diffuse large B‐cell
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Altered prolactin and androgen receptors expression in companion rat benign mammary tumours Vet. Comp. Oncol. (IF 1.749) Pub Date : 2020-11-15 Claire Vergneau‐Grosset; Caroline Cluzel; Guy Beauchamp; Neil E. Hubbard; Joanne Paul‐Murphy; Marilène Paquet
Benign mammary tumours are among the most common tumours of companion rats (Rattus norvegicus domestica), as well as a major animal welfare concern and euthanasia. The first objective of this study was to evaluate the expression of oestrogen, progesterone, androgen, and prolactin receptors in neoplastic and normal mammary gland tissues and compare the expression of these receptors between groups. The
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The number of glutamines in the N‐terminal of the canine androgen receptor affects signalling intensities Vet. Comp. Oncol. (IF 1.749) Pub Date : 2020-11-10 Kazuhiko Ochiai; Samak Sutijarit; Mitsuki Uemura; Masami Morimatsu; Masaki Michishita; Eri Onozawa; Marika maeda; Takanori Sasaki; Masami Watanabe; Yoshikazu Tanaka; Toshinori Omi
Most male dogs are castrated at young ages, making them easy to rear following androgen deprivation. Although the incidence of canine prostate cancer is low, several patients have resistance to androgen therapy and poor clinical prognosis. These outcomes are similar to those of end‐stage human androgen‐independent prostate cancer. The androgen receptor (AR) of canines has two polyglutamine (polyQ)
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Long‐term outcomes with conventional fractionated and stereotactic radiotherapy for suspected heart‐base tumours in dogs Vet. Comp. Oncol. (IF 1.749) Pub Date : 2020-11-02 Katherine S. Hansen; Alain P. Théon; Jennifer L. Willcox; Joshua A. Stern; Michael S. Kent
Published radiotherapy results for suspected heart‐based tumours in dogs are limited. In this retrospective longitudinal study (3/2014‐2019), eight dogs with either clinical signs attributable to a heart‐base mass (6), or asymptomatic with a progressively larger mass on echocardiogram (2), received conventional fractionated radiotherapy (CFRT) or stereotactic body radiotherapy (SBRT). Clinical findings
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Adjuvant doxorubicin vs metronomic cyclophosphamide and meloxicam vs surgery alone for cats with mammary carcinomas: A retrospective study of 137 cases Vet. Comp. Oncol. (IF 1.749) Pub Date : 2020-11-03 Gonçalo N. Petrucci; Joaquim Henriques; Luís Lobo; Hugo Vilhena; Ana C. Figueira; Ana Canadas‐Sousa; Patrícia Dias‐Pereira; Justina Prada; Isabel Pires; Felisbina L. Queiroga
This study aims to evaluate the efficacy and side effects of low dose cyclophosphamide chemotherapy plus meloxicam as an adjuvant treatment, compared with high dose doxorubicin or surgery alone in cats with mammary carcinoma. Medical records of 228 female cats treated for mammary carcinoma between 2008 and 2018, were reviewed in eight veterinary institutions. Only cats with complete tumour staging
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Canine lymphoma and vector‐borne diseases: Molecular and serological evaluation of a possible complicity Vet. Comp. Oncol. (IF 1.749) Pub Date : 2020-10-17 Joaquim Henriques; Ricardo Felisberto; Bruno Almeida; Joana Ramos; Fernando Constantino‐Casas; Jane Dobson; Raquel Matos; Ana Santos; Rita de Sousa; Margarida Alves
Lymphoma is the most common haematological malignancy in dogs and its aetiology is largely unknown. The presence of canine vector‐borne agents (CVBD) in lymphoma tissues has been described and its causative effects questioned. We intended to evaluate the presence and extent of Leishmania infantum, Ehrlichia canis, Anaplasma phagocytophilum and Bartonella henselae infection in dogs with lymphoma. Sixty‐one
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In situ c-KIT mRNA quantification of canine cutaneous mast cell tumors and its relationship to prognostic factors. Vet. Comp. Oncol. (IF 1.749) Pub Date : 2020-09-14 Byung-Joon Seung,Seung-Hee Cho,Soo-Hyeon Kim,Min-Kyung Bae,Ha-Young Lim,Jung-Hyang Sur
Cutaneous mast cell tumours (MCTs) are the most frequent malignant skin tumours in dogs. Mutations in the c‐KIT proto‐oncogene are correlated with the pathogenesis and aggressiveness of MCTs. To date, studies have focused on c‐KIT mutations and KIT protein localization, with a general lack of mRNA‐level analyses. In this study, c‐KIT mRNA expression was investigated in canine MCTs by RNA in situ hybridization
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The oncogenic pathways of papillomaviruses Vet. Comp. Oncol. (IF 1.749) Pub Date : 2020-10-21 Onur Kaynarcalidan; Tuba Çiğdem Oğuzoğlu
Papillomaviruses are oncogenic DNA viruses and induce hyperplastic benign lesions of both cutaneous and mucosal tissues in their various hosts, including many domestic and wild animals as well as humans. There are some Papillomavirus genotypes that can infect hosts different from their own, such as BPV 1 and BPV 2 originated from cattle, which can also infect horses and are responsible for fibroblastic
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Canine mammary tumours: Size matters - a progression from low to highly malignant subtypes. Vet. Comp. Oncol. (IF 1.749) Pub Date : 2020-09-17 Julia Gedon,Axel Wehrend,Klaus Failing,Martin Kessler
The purpose of this study was to evaluate a possible association between mammary tumour size and increasing degree of malignancy. Data of 625 dogs with a total of 1459 mammary tumours were analysed retrospectively. 80.3% dogs were intact, mean age at diagnosis was 9.7 ± 2.5 years, 75.8% were pure breed dogs. Median body weight was 20.0 kg. Malignant tumours (n = 580) were significantly larger than
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Predicting likelihood of in vivo chemotherapy response in canine lymphoma using ex vivo drug sensitivity and immunophenotyping data in a machine learning model Vet. Comp. Oncol. (IF 1.749) Pub Date : 2020-10-06 Zach Bohannan; Raghavendra Sumanth Pudupakam; Jamin Koo; Harrison Horwitz; Josephine Tsang; Amanda Polley; Enyang James Han; Elmer Fernandez; Stanley Park; Deanna Swartzfager; Nicholas Seah Xi Qi; Chantal Tu; Wendi Velando Rankin; Douglas H. Thamm; Hye‐Ryeon Lee; Sungwon Lim
We report a precision medicine platform that evaluates the probability of chemotherapy drug efficacy for canine lymphoma by combining ex vivo chemosensitivity and immunophenotyping assays with computational modelling. We isolated live cancer cells from fresh fine needle aspirates of affected lymph nodes and collected post‐treatment clinical responses in 261 canine lymphoma patients scheduled to receive
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Significant association of serum autoantibodies to TYMS, HAPLN1 and IGFBP5 with early stage canine malignant mammary tumours Vet. Comp. Oncol. (IF 1.749) Pub Date : 2020-10-10 Shih‐Chieh Chang; Stephen Hsien‐Chi Yuan; Chia‐Yin Li; Huan‐Ming Chang; Heng‐Cian Wang; Yun‐An Pan; Pei‐Chun Hsueh; Chih‐Ching Wu; Youngsen Yang; Hao‐Ping Liu
Canine mammary tumours (CMTs) are the most prevalent neoplasms in female dogs. Despite the high incidence of such tumours, a lack of easily accessible biomarkers still impedes early diagnosis of malignant CMTs. Herein we identify thymidylate synthetase (TYMS), hyaluronan and proteoglycan link protein 1 (HAPLN1) and insulin‐like growth factor‐binding protein 5 (IGFBP5) as CMT antigens eliciting corresponding
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The feasibility and utility of optical coherence tomography directed histopathology for surgical margin assessment of canine mast cell tumors. Vet. Comp. Oncol. (IF 1.749) Pub Date : 2020-09-20 Josephine A Dornbusch,Christina Cocca,Ryan Jennings,Jonathan Samuelson,Miranda Vieson,Pin-Chieh Huang,Stephen A Boppart,Vincent A Wavreille,Laura E Selmic
Histopathologic surgical margin assessment in veterinary patients is an imprecise science with assessment limited to a small proportion of the surgical margin due to time and finances. Incomplete excision of canine mast cell tumours (MCTs) alters treatment recommendations and prognosis. Optical coherence tomography (OCT) is a novel imaging modality that has been reported in a single veterinary study
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Treatment of canine oral papillary squamous cell carcinoma using definitive‐intent radiation as a monotherapy—a case series Vet. Comp. Oncol. (IF 1.749) Pub Date : 2020-09-25 Francine van der Steen; Maurice Zandvliet
Canine oral papillary squamous cell carcinoma (COPSCC) is a rare neoplasm and although locally invasive it carries a favourable prognosis following wide surgical excision. Radiotherapy has been reported to be effective as an adjunct treatment to surgery. However, limited information is available on the role of radiotherapy as single treatment. This single‐institution retrospective study describes a
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One-year conditional survival of dogs and cats with invasive mammary carcinomas: A concept inspired from human breast cancer. Vet. Comp. Oncol. (IF 1.749) Pub Date : 2020-09-21 Florian Chocteau,Valentin Mordelet,Elie Dagher,Delphine Loussouarn,Jérôme Abadie,Frédérique Nguyen
Numerous studies have described the prognostic factors of canine and feline mammary carcinomas (MCs), that is, variables that predict patient survival after diagnosis. But how does survival estimation evolve in patients that escaped early death from their cancer? In human oncology, conditional survival (CS), the probability of surviving X further years when cancer patients have already survived Y years
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Biological behaviour of primary osteosarcoma of the digits, metacarpal and metatarsal bones in dogs. Vet. Comp. Oncol. (IF 1.749) Pub Date : 2020-09-07 Giovanni Tremolada,Douglas H Thamm,Milan Milovancev,Bernard Seguin
Osteosarcoma (OSA) arising from the digits, metatarsal and metacarpal bones is rare and may carry a better prognosis compared with other locations. The aim of this study was to retrospectively evaluate the biological behaviour, the progression free interval (PFI), the survival time (ST) and evaluate the effect of adjuvant chemotherapy for OSA affecting these bones. Medical records from two academic
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Assessment of biomarkers influencing treatment success on small intestinal lymphoma in dogs. Vet. Comp. Oncol. (IF 1.749) Pub Date : 2020-09-13 Hiroki Yamazaki,Hiroshi Sasai,Miyuu Tanaka,Toshiyuki Tanaka,Hidetaka Nishida,Shunsuke Noguchi,Mitsuru Kuwamura,Hideo Akiyoshi
This study aimed to determine a reliable therapeutic biomarker for localized small intestinal lymphoma (SIL) in dogs based on clinical and histopathological features. We retrospectively investigated 84 dogs with localized SIL, including 36 dogs receiving surgery and 48 dogs receiving chemotherapy. The dogs receiving surgery were divided into two subgroups: 18 dogs (group 1) with overall survival (OS)
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Evaluation of accuracy for 18 F-FDG positron emission tomography and computed tomography for detection of lymph node metastasis in canine oral malignant melanoma. Vet. Comp. Oncol. (IF 1.749) Pub Date : 2020-09-06 Jennifer L Willcox,Mathieu Spriet,Allison L Zwingenberger,Kathryn L Phillips,Jenna H Burton,Katherine A Skorupski,Katherine S Hansen,Verena K Affolter,Kevin D Woolard,David Beylin,Michelle A Giuffrida
Tumour stage has been demonstrated to have prognostic significance in canine oral malignant melanoma (OMM). Various evaluation techniques of positron emission tomography/computed tomography (PET/CT) have been reported for staging of head‐and‐neck tumours in people, but canine‐specific data are limited, and reports for CT accuracy have been variable. In this prospective study, the head/neck of client‐owned
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miR-497 induces apoptosis by the IRAK2/NF-κB axis in the canine mammary tumour. Vet. Comp. Oncol. (IF 1.749) Pub Date : 2020-07-24 Tao Zhang,Xiujuan Feng,Tianhong Zhou,Ning Zhou,Xue Shi,Xinying Zhu,Jinxia Qiu,Ganzhen Deng,Changwei Qiu
Since companion dogs have the same living environment as humans, they are a good animal model for the study of human diseases; this is especially true of canine spontaneous mammary tumours models. A better understanding of the natural history and molecular mechanisms of canine mammary tumour is of great significance in comparative medicine. Here, we collected canine mammary tumour cases and then assayed
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Immunoexpression of epithelial membrane antigen in canine meningioma: Novel results for perspective considerations. Vet. Comp. Oncol. (IF 1.749) Pub Date : 2020-09-02 Maria Teresa Mandara,Greta Foiani,Serenella Silvestri,Elisabetta Chiaradia
Epithelial membrane antigen (EMA) is one of the most widely used diagnostic immunohistochemical markers for human meningioma. To date, no published study on EMA expression in formalin‐fixed paraffin‐embedded (FFPE) tissue samples of canine meningioma is available. Here, we describe the results of an immunohistochemical study on 25 FFPE canine meningiomas using a monoclonal anti‐human EMA antibody.
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Contrast-enhanced ultrasound for sentinel lymph node mapping in the routine staging of canine mast cell tumours: A feasibility study. Vet. Comp. Oncol. (IF 1.749) Pub Date : 2020-08-24 Quentin Fournier,Florence Thierry,Maurizio Longo,Alexandra Malbon,Paola Cazzini,Jocelyn Bisson,Samantha Woods,Tiziana Liuti,Spela Bavcar
Canine mast cell tumours (MCTs) typically spread to lymph nodes (LNs) before reaching distant sites, and LN assessment is an important part of MCT staging. Sentinel LN (SLN) mapping techniques to identify draining LNs are being developed and could improve the accuracy of MCT staging. The primary objective of this feasibility study was to determine the safety and effectiveness of contrast‐enhanced ultrasound
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Kynurenine 3-monooxygenase (KMO), and signal transducer and activator of transcription 3 (STAT3) expression is involved in tumour proliferation and predicts poor survival in canine melanoma. Vet. Comp. Oncol. (IF 1.749) Pub Date : 2020-07-27 I-Li Liu,Ting-Fang Chung,Wei-Hsiang Huang,Chia-Hui Hsu,Cheng-Chi Liu,Yi-Han Chiu,Kuo-Chin Huang,Albert Tai-Ching Liao,Chen-Si Lin
Canine melanoma is a malignant tumour that exhibits aggressive behaviour, and frequently metastasizes to regional lymph nodes and distant sites. Currently, there are no effective treatments or practical prognostic biomarkers for canine melanoma. The enzyme kynurenine 3‐monooxygenase (KMO), which plays a central role in the tryptophan metabolism, has previously been identified as the main pathogenic
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Clinical outcome in 23 dogs with exocrine pancreatic carcinoma. Vet. Comp. Oncol. (IF 1.749) Pub Date : 2020-08-17 Christopher J Pinard,Samuel E Hocker,Kristen M Weishaar
Exocrine pancreatic carcinoma is uncommon in the dog and the veterinary literature surrounding the disease is minimal. Twenty‐three cases of canine exocrine pancreatic carcinoma were reviewed in a retrospective manner to obtain information on clinical presentation, behaviour and survival associated with the disease. Presenting clinical signs were nonspecific and included anorexia, lethargy, vomiting
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Fasting reduces the incidence of vincristine‐associated adverse events in dogs Vet. Comp. Oncol. (IF 1.749) Pub Date : 2020-07-20 Margaret E. Duckett; Kaitlin M. Curran; Haley J. Leeper; Carl E. Ruby; Shay Bracha
Fasting has been shown to decrease chemotherapy‐associated adverse events (AEs), in part through insulin‐like growth factor (IGF‐1) reduction, and may induce a protective effect on normal cells during chemotherapy treatment in mice and people. The purpose of this study was to evaluate the effect of fasting on constitutional, bone marrow and gastrointestinal (GI) AEs, and serum glucose, IGF‐1 and insulin
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Effect of simvastatin on cell proliferation and Ras activation in canine tumour cells. Vet. Comp. Oncol. (IF 1.749) Pub Date : 2020-08-11 Kosuke Kobayashi,Kenji Baba,Satoshi Kambayashi,Masaru Okuda
Statins are inhibitors of the mevalonate cascade that is responsible for cholesterol biosynthesis and the formation of intermediate metabolites, farnesyl pyrophosphate (FPP) and geranylgeranyl pyrophosphate (GGPP) used in the prenylation of proteins. Although statins are widely used in the treatment of hypercholesterolemia, recent studies suggest that they also inhibit proliferation of tumour cells
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Safety evaluation of the canine osteosarcoma vaccine, live Listeria vector. Vet. Comp. Oncol. (IF 1.749) Pub Date : 2020-07-30 Margaret L Musser,Erika P Berger,Chelsea D Tripp,Craig A Clifford,Philip J Bergman,Chad M Johannes
Canine osteosarcoma (OSA) is an aggressive bone tumour in dogs. Standard‐of‐care treatment typically results in relatively short survival times; thus, alternative treatments are needed to confer a survival advantage. It has been shown that OSA is an immunogenic tumour, suggesting that immune modulation may result in superior outcomes. A cryopreserved, Listeria‐based OSA vaccine was recently developed
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A retrospective analysis on the outcome of 18 dogs with malignant ovarian tumours. Vet. Comp. Oncol. (IF 1.749) Pub Date : 2020-07-22 Sho Goto,Ryota Iwasaki,Hiroki Sakai,Takashi Mori
Little evidence is available regarding the prognosis of dogs with malignant ovarian tumours. The objective of this retrospective study was to describe the outcomes and determine the prognostic factors for dogs with malignant ovarian tumours following treatment, including surgery with or without adjuvant therapy. Eighteen dogs were studied, their median age was 12 years (range: 7‐15 years), and their
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Outcomes of Cats Treated with Maxillectomy: 60 Cases. A Veterinary Society of Surgical Oncology Retrospective Study. Vet. Comp. Oncol. (IF 1.749) Pub Date : 2020-06-26 J M Liptak,G P Thatcher,L A Mestrinho,B Séguin,T Vernier,M Martano,B D Husbands,S Veytsman,S A van Nimwegen,C H De Mello Souza,R A Mullins,S L Barry,S E Selmic
Maxillectomy is poorly described for the management of oral tumours in cats and is occasionally not recommended because of the high complication rate and sub‐optimal outcome reported in cats treated with mandibulectomy. The purpose of this study was to retrospectively evaluate the complications and oncologic outcome in cats treated with maxillectomy. Sixty cats were included in the study. Maxillectomy
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Effect of perioperative desmopressin in cats with mammary carcinoma treated with bilateral mastectomy. Vet. Comp. Oncol. (IF 1.749) Pub Date : 2020-07-03 Christopher J Wood,Margaret L Chu,Laura E Selmic,Philipp D Mayhew,David E Holt,Marina Martano,Bernard Séguin,Ameet Singh,Sarah E Boston,Cassie Lux,Julius M Liptak
Perioperative administration of desmopressin has shown to significantly decrease rates of local recurrence and metastasis, and increase survival times in dogs with grade II and III mammary carcinomas. The objective of this study was to compare the oncologic outcome of cats with mammary carcinoma treated with bilateral mastectomy with or without perioperative administration of desmopressin. Medical
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Response from the authors: A prospective randomized trial of desmopressin in canine mammary carcinoma. Vet. Comp. Oncol. (IF 1.749) Pub Date : 2020-08-02 Karin Sorenmo
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Association between weight change during initial chemotherapy and clinical outcome in dogs with multicentric lymphoma. Vet. Comp. Oncol. (IF 1.749) Pub Date : 2020-07-12 Wei-Shan Lee,Jih-Jong Lee,Albert Taiching Liao,Chia-Lien Kao,Shang-Lin Wang
The majority of the known prognostic factors in dogs with lymphoma have been evaluated before treatment commences or at the time of diagnosis. Prognostic factors evaluated during the initial phase of treatment are less described but may provide important clinical information. In this retrospective study, 82 canine lymphoma patients were categorized according to the weight change between diagnosis and
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Outcome after surgical management of canine insulinoma in 49 cases. Vet. Comp. Oncol. (IF 1.749) Pub Date : 2020-06-17 Nicholas Trevor Cleland,John Morton,Peter James Delisser
Canine insulinoma has historically been associated with a poor prognosis; however, prolonged survival times have recently been reported. Prognostic indicators that are available preoperatively are of limited predictive accuracy, and consensus on post‐operative treatment recommendations is lacking. The objectives of this study were to describe outcomes in dogs with insulinoma treated surgically, and
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Repeatable and objective method for evaluating angiogenesis using real-time RT-PCR of endoglin expression in canine tumours. Vet. Comp. Oncol. (IF 1.749) Pub Date : 2020-06-27 Mayu Kimura,Masahiro Yamasaki,Hiroshi Satoh,Naohiro Uchida
Anti‐angiogenic therapy is a cancer treatment strategy targeting new blood vessel formation. Microvessel density (MVD) is a histopathological method for evaluating angiogenesis and endoglin is used as an activated endothelial marker in human medicine. The assessment of the treatment effect using MVD is difficult because it is a non‐repeatable method. To develop a repeatable method for evaluating angiogenesis
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Evaluating optical coherence tomography for surgical margin assessment of canine mammary tumours. Vet. Comp. Oncol. (IF 1.749) Pub Date : 2020-06-20 Carolina Fabelo,Laura E Selmic,Pin-Cheh Huang,Jonathan P Samuelson,Jennifer K Reagan,Alexandra Kalamaras,Vincent Wavreille,Guillermo L Monroy,Marina Marjanovic,Stephen A Boppart
Optical coherence tomography (OCT) uses near‐infrared light waves to generate real‐time, high‐resolution images on the microscopic scale similar to low power histopathology. Previous studies have demonstrated the use of OCT for real‐time surgical margin assessment for human breast cancer. The use of OCT for canine mammary tumours (CMT) could allow intra‐operative visualisation of residual tumour at
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Chemotherapy-induced diarrhoea in dogs and its management with smectite: Results of a monocentric open-label randomized clinical trial. Vet. Comp. Oncol. (IF 1.749) Pub Date : 2020-06-20 Quentin Fournier,Juan-Carlos Serra,Claire Williams,Spela Bavcar
Chemotherapy‐induced diarrhoea (CID) is a frequent chemotherapy adverse event in dogs. Yet, there is currently no consensus regarding its management. Smectite is a natural medical clay, widely used in the treatment of acute diarrhoea in humans. The objectives of this study were to assess the efficacy of smectite in the management of CID in dogs, and to collect epidemiological data on CID. For each
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Treatment outcomes and target delineation utilizing CT and MRI in 13 dogs treated with a uniform stereotactic radiation therapy protocol (16 Gy single fraction) for pituitary masses: (2014-2017). Vet. Comp. Oncol. (IF 1.749) Pub Date : 2020-06-16 Tracy L Gieger,Michael W Nolan
Canine pituitary tumours are increasingly treated with stereotactic radiotherapy (SRT). Here, we report clinical outcomes in dogs treated with single‐fraction SRT; we also explore technical aspects of SRT treatment planning. A single‐institution retrospective study was performed, including any dog with a pituitary mass (PM) that was treated using a standardized single‐fraction (16 Gy) SRT protocol
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Evaluation of a modified proportional margin approach for complete surgical excision of canine cutaneous mast cell tumours and its association with clinical outcome. Vet. Comp. Oncol. (IF 1.749) Pub Date : 2020-06-18 Harvey Saunders,Maurine J Thomson,Kathleen O'Connell,Janis P Bridges,Lincoln Chau
Canine cutaneous mast cell tumours (MCTs) represent a common neoplasm in veterinary practice. Several reported techniques are available to guide surgical excision. Our study examined one hundred cutaneous MCTs that were excised surgically using a modified proportional margin approach. A 2 cm lateral margin upper limit was applied for any tumour diameter that exceeded this size with a deep surgical
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Desmopressin in canine mammary carcinoma: Comments on the importance of the administration route. Vet. Comp. Oncol. (IF 1.749) Pub Date : 2020-07-22 Daniel F Alonso,Esteban Turic,Juan Garona
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Prognostic value of pretreatment plasma D-dimer level in dogs with intermediate to high-grade non-Hodgkin lymphoma. Vet. Comp. Oncol. (IF 1.749) Pub Date : 2020-07-09 Pierre Boyé,François Serres,Franck Floch,Corinne Fournel-Fleury,Dominique Tierny
Pretreatment D‐dimer levels have been reported to predict survival in several types of malignancies in human patients. The objective of this study was to evaluate the prognostic value of pretreatment D‐dimer level in dogs with intermediate to high‐grade non‐Hodgkin lymphoma (NHL). In a prospective, randomized, double‐blind study of F14512 vs etoposide phosphate, we assessed the prognostic value of
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Optical coherence tomography imaging of excised canine apocrine gland anal sac adenocarcinoma tumours. Vet. Comp. Oncol. (IF 1.749) Pub Date : 2020-06-20 Josephine A Dornbusch,Laura E Selmic,Pin-Chieh Huang,Jonathan P Samuelson,Christina Cocca,Vincent A Wavreille,Stephen A Boppart
Optical coherence tomography (OCT) is an optical imaging modality that has been investigated for real‐time surgical margin evaluation in human breast cancer patients. Previous veterinary OCT studies have been limited to surgical margin imaging for soft tissue sarcoma (STS) tumours. To the authors knowledge, OCT has never been used to characterize or evaluate other types of neoplasia in dogs. The goal
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Safety and efficacy of stereotactic body radiation therapy (SBRT) for the treatment of canine thyroid carcinoma. Vet. Comp. Oncol. (IF 1.749) Pub Date : 2020-06-09 Ber-In Lee,Susan M LaRue,Bernard Seguin,Lynn Griffin,Amber Prebble,Tiffany Martin,Del Leary,Mary-Keara Boss
Thyroid carcinoma develops spontaneously in dogs, with only 25% to 50% of cases amenable to surgery at diagnosis. Local control for unresectable tumours can be provided with external beam radiotherapy. The aim of this retrospective study is to describe the safety and efficacy of stereotactic body radiation therapy (SBRT) for treatment of canine thyroid carcinoma. Twenty‐three dogs met inclusion criteria;
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An open-label dose escalation study evaluating tolerability and safety of a single 5-days course of temozolomide in dogs with advanced cancer. Vet. Comp. Oncol. (IF 1.749) Pub Date : 2020-06-08 Laura Marconato,Carla Rohrer Bley,Vito F Leone,Riccardo Finotello
Temozolomide is a novel oral alkylating agent that has schedule‐dependent clinical activity in human malignant glioma and metastatic melanoma. Little is known about the efficacy of temozolomide in the treatment of canine solid cancers, where broad range of dosages have been used but no maximally tolerated dose (MTD) had been established. The aim of this this open‐label, dose‐escalating study was to
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Analysis of DNA methylation and TP53 mutational status for differentiating feline oral squamous cell carcinoma from non-neoplastic mucosa: A preliminary study. Vet. Comp. Oncol. (IF 1.749) Pub Date : 2020-06-07 Andrea Renzi,Luca Morandi,Jacopo Lenzi,Antonella Rigillo,Giuliano Bettini,Emma Bellei,Alessandra Giacomini,Debora Tinto,Silvia Sabattini
Feline oral squamous cell carcinoma (FOSCC) is characterized by high local invasiveness and early bone lysis. The late diagnosis largely limits the efficacy of therapy and increases treatment‐related morbidity. The aim of this exploratory study was to assess the methylation pattern of 10 candidate genes and TP53 mutational status in histologic samples of FOSCC. Results were compared with normal oral
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Histologic margins and the residual tumour classification scheme. Vet. Comp. Oncol. (IF 1.749) Pub Date : 2020-06-04 Julius M Liptak
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Prospective observational study of dogs with splenic mass rupture suggests potentially lower risk of malignancy and more favourable perioperative outcomes. Vet. Comp. Oncol. (IF 1.749) Pub Date : 2020-05-26 Samuel D Stewart,E J Ehrhart,Rebecca Davies,Chand Khanna
Haemoperitoneum secondary to ruptured splenic tumours can be either benign or malignant in origin. The majority of previous studies of canine haemoperitoneum have been retrospective, which are associated with well‐recognized biases, such as the potential to underappreciate the diversity of outcomes in a complex presentation such as haemoperitoneum. This study seeks to prospectively define perioperative
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