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Evaluation of the cytotoxic and genotoxic effects of Sida planicaulis Cav extract using human neuroblastoma cell line SH-SY5Y J. Toxicol. Environ. Health Part A (IF 2.653) Pub Date : 2021-01-12 Mariana Terezinha Selbach; Amanda Souza Scotti; Cleverson Costa Feistel; Caroline C. Nicolau; Daiana Dalberto; Natália Garcia dos Santos; Guilherme Borsoi; Alexandre Barros Falcão Ferraz; Ivana Grivicich; Guilherme Maurício Soares de Souza; Paola Chytry; Johnny Ferraz Dias; Dione Silva Corrêa; Juliana da Silva
ABSTRACT Sida planicaulis is a weed thought to have originated in Brazil, where it is present in abundant quantities, but also this plant is also found in south-central Florida, Indian Ocean Islands, and the Pacific Islands. Sida planicaulis produces neurotoxicity that adversely affects livestock breeding with heavy animal losses and consequent negative impact on Brazil’s economy. The aim of this study
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Docosahexaenoic acid impacts macrophage phenotype subsets and phagolysosomal membrane permeability with particle exposure J. Toxicol. Environ. Health Part A (IF 2.653) Pub Date : 2020-11-04 Paige Fletcher; Raymond F. Hamilton Jr.; Joseph F. Rhoderick; James J. Pestka; Andrij Holian
ABSTRACT Inhalation of particles results in pulmonary inflammation; however, treatments are currently lacking. Docosahexaenoic acid (DHA) is an omega-3 polyunsaturated fatty acid shown to exhibit anti-inflammatory capabilities. The impact of DHA on particle-induced inflammation is unclear; therefore, the aim of this study was to examine the hypothesis that DHA downregulates macrophage inflammatory
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Effects of several atypical antipsychotics closapine, sertindole or ziprasidone on hepatic antioxidant enzymes: Possible role in drug-induced liver dysfunction J. Toxicol. Environ. Health Part A (IF 2.653) Pub Date : 2020-11-24 Lena Platanić Arizanović; Aleksandra Nikolić-Kokić; Jelena Brkljačić; Nikola Tatalović; Marko Miler; Zorana Oreščanin-Dušić; Teodora Vidonja Uzelac; Milan Nikolić; Verica Milošević; Duško Blagojević; Snežana Spasić; Čedo Miljević
ABSTRACT Chronic use of atypical antipsychotics may produce hepatic damage. Atypical antipsychotics, including clozapine, sertindole, and ziprasidone, are extensively metabolized by the liver and this process generates toxic-free radical metabolic intermediates which may contribute to liver damage. The aim of this study was to investigate whether clozapine, sertindole, or ziprasidone affected hepatic
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Zearalenone perturbs the circadian clock and inhibits testosterone synthesis in mouse Leydig cells J. Toxicol. Environ. Health Part A (IF 2.653) Pub Date : 2020-11-04 Lijia Zhao; Yaoyao Xiao; Cuimei Li; Jing Zhang; Yaojia Zhang; Meina Wu; Tiantian Ma; Luda Yang; Xiaoyu Wang; Haizhen Jiang; Qian Li; Hongcong Zhao; Yiqun Wang; Aihua Wang; Yaping Jin; Huatao Chen
ABSTRACT Zearalenone (ZEA), a mycotoxin, is known to impair reproductive capability by disrupting the synthesis and secretion of testosterone by Leydig cells (LCs), although the mechanism is unknown. Robust rhythmicity of circadian clock and steroidogenic genes were identified in LCs. The aim of this study was to examine whether ZEA significantly attenuated the transcription of core clock genes (Bmal1
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Comparison of zebrafish in vitro and in vivo developmental toxicity assessments of perfluoroalkyl acids (PFAAs) J. Toxicol. Environ. Health Part A (IF 2.653) Pub Date : 2020-11-03 Ola Wasel; Kathryn M. Thompson; Yu Gao; Amy E. Godfrey; Jiejun Gao; Cecon T. Mahapatra; Linda S. Lee; Maria S. Sepúlveda; Jennifer L. Freeman
ABSTRACT Perfluoroalkyl acids (PFAAs) are persistent environmental contaminants that are associated with various adverse health outcomes. Perfluorooctanoic acid (PFOA) is one of the most prominently detected PFAAs in the environment, which is now replaced with shorter chain carbon compounds including perfluorohexanoic acid (PFHxA) and perfluorobutyric acid (PFBA). The aim of this study was to compare
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Evaluation of models for predicting pediatric fraction unbound in plasma for human health risk assessment J. Toxicol. Environ. Health Part A (IF 2.653) Pub Date : 2020-10-26 Yejin Esther Yun; Andrea N. Edginton
ABSTRACT Pediatric physiologically based pharmacokinetic (PBPK) models facilitate the prediction of PK parameters in children under specific exposure conditions. Pharmacokinetic outcomes are highly sensitive to fraction unbound in plasma (fup) as incorporated into PBPK models. Rarely is fup in children (fupchild) experimentally derived and prediction is based upon fup in adults (fupadult) as well as
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Metabolomics approach to biomarkers of dry eye disease using 1H-NMR in rats J. Toxicol. Environ. Health Part A (IF 2.653) Pub Date : 2021-01-03 Jung Dae Lee; Hyang Yeon Kim; Jin Ju Park; Soo Bean Oh; Hyeyoon Goo; Kyong Jin Cho; Suhkmann Kim; Kyu-Bong Kim
ABSTRACT Dry eye disease (DED) is a chronic and progressive lesion on the ocular surface and induces symptoms, such as burning sensation, itchy eyes, heavy eyes, tired eyes, dry feeling, facial flushing, and blurred vision. The present study was performed to develop DED biomarkers using metabolomics in a rat model. DED was induced by injecting scopolamine and exposing rats to a dry condition. Scopolamine
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21-Day dermal exposure to aircraft engine oils: effects on esterase activities in brain and liver tissues, blood, plasma, and clinical chemistry parameters for Sprague Dawley rats J. Toxicol. Environ. Health Part A (IF 2.653) Pub Date : 2020-12-30 Isaie Sibomana; Joyce G. Rohan; David R. Mattie
ABSTRACT This dermal study tested the potential toxicity of grade 3 (G3) and 4 (G4) organophosphate-containing aircraft engine oils in both new (G3-N, G4-N) and used states (G3-U, G4-U) to alter esterase activities in blood, brain and liver tissues, clinical chemistry parameters, and electrophysiology of hippocampal neurons. A 300 µl volume of undiluted oil was applied in Hill Top Chamber Systems®
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Safety and bioactivity assessment of aqueous extract of Thai Henna (Lawsonia inermis Linn.) Leaf J. Toxicol. Environ. Health Part A (IF 2.653) Pub Date : 2020-12-29 Orawan Khantamat; Nahathai Dukaew; Jirarat Karinchai; Teera Chewonarin; Pornsiri Pitchakarn; Piya Temviriyanukul
ABSTRACT The worldwide demand for a natural dye by the cosmetic and food industry has recently gained interest. To provide scientific data supporting the usage of Thai henna leaf as a natural colorant, the phytochemical constituents, safety, and bioactivity of aqueous extract of the henna leaf by autoclave (HAE) and hot water (HHE) were determined. HAE contained a higher amount of total phenolic and
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Recombinogenic, genotoxic, and cytotoxic effects of azathioprine using in vivo assays J. Toxicol. Environ. Health Part A (IF 2.653) Pub Date : 2020-12-29 A. V. D. Melo Bisneto; L. C. D. Oliveira; A. Silva Fernandes; Luana Silva; J. H. Véras; Clever Cardoso; Carolina R. E Silva; A. V. de Moraes Filho; Carneiro Carneiro; L. Chen-Chen
ABSTRACT Azathioprine (Aza) is a purine antimetabolite immunosuppressant that is widely employed for immunosuppressive therapy in post-transplant recipients or patients with autoimmune diseases. Chronic use of immunosuppressants might produce several side effects, including a high rate of neoplasms in these patients. Considering that genotoxic effects are associated with an increased risk of developing
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Antigenotoxic effects of (-)-epigallocatechin-3-gallate (EGCG) and its relationship with the endogenous antioxidant system, 8-hydroxydeoxyguanosine adduct repair (8-OHdG), and apoptosis in mice exposed to chromium(VI) J. Toxicol. Environ. Health Part A (IF 2.653) Pub Date : 2020-12-29 María Del Carmen García-Rodríguez; Gabriela Serrano-Reyes; Lourdes Montserrat Hernández-Cortés; Mario Altamirano-Lozano
ABSTRACT This study aimed to investigate the relationship between endogenous antioxidant system, 8-hydroxydeoxyguanosine adduct (8-OHdG) repair, and apoptosis in mice treated with chromium(VI) alone and in the presence of the antigenotoxic compound (-)-epigallocatechin-3-gallate (EGCG). Groups of 5 Hsd:ICR male mice were divided and treated as follows: (1) control, vehicle only; (2) EGCG, 8.5 mg/kg
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Polyethylene, Polystyrene, and Polypropylene leachate impact upon marine microalgae Dunaliella tertiolecta J. Toxicol. Environ. Health Part A (IF 2.653) Pub Date : 2020-12-28 Simona Schiavo; Maria Oliviero; Salvatore Chiavarini; Stefano Dumontet; Sonia Manzo
ABSTRACT In the aquatic environment, plastics may release several hazardous substances of severe ecotoxicological concern not covalently bound to the polymers. The aim of this study was to examine the adverse effects of leachates of different virgin polymers, polypropylene (PP), polyethylene (PE), and polystyrene (PS) on marine microalgae Dunaliella tertiolecta. The tests carried out on D. tertiolecta
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Effects of an environmentally relevant PCB-mixture on immune function, clinical chemistry, and thyroid hormone levels in adult female B6C3F1 mice J. Toxicol. Environ. Health Part A (IF 2.653) Pub Date : 2020-12-23 Patricia A. Fair; Margie M. Peden-Adams; Meagan A.M. Mollenhauer; Gregory D. Bossart; Deborah E. Keil; Natasha D. White
ABSTRACT Polychlorinated biphenyls (PCBs) have been assessed for immunotoxicity; however, humans and wildlife are exposed to multiple PCBs environmentally. Therefore, the aim of this study was to examine the effects of a complex 37 PCB congener mixture identified in blubber specific to dolphins residing in the estuarine waters of Charleston, South Carolina. Immunotoxicity was determined in adult female
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Assessment of air pollution at the indoor environment of a shooting range using lichens as biomonitors J. Toxicol. Environ. Health Part A (IF 2.653) Pub Date : 2020-12-17 Gintarė Sujetovienė; Jūratė Česynaitė
ABSTRACT The aim of the study was to examine the changes in ecophysiological parameters and accumulation of heavy metals in lichens transplanted to a shooting-range environment. Thalli of the epiphytic lichen were transplanted from an unpolluted site to a shooting range. Chlorophyll a fluorescence, thiobarbituric acid reactive substances (TBARS), and damage to cell membranes in the lichen Evernia prunastri
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Ozone-induced acute phase response in lung versus liver: the role of adrenal-derived stress hormones J. Toxicol. Environ. Health Part A (IF 2.653) Pub Date : 2020-12-14 Devin I. Alewel; Andres R. Henriquez; Catherine H. Colonna; Samantha J. Snow; Mette C. Schladweiler; Colette N. Miller; Urmila P. Kodavanti
ABSTRACT Acute-phase response (APR) is an innate stress reaction to tissue trauma or injury, infection, and environmental insults like ozone (O3). Regardless of the location of stress, the liver has been considered the primary contributor to circulating acute-phase proteins (APPs); however, the mechanisms underlying APR induction are unknown. Male Wistar–Kyoto rats were exposed to air or O3 (1 ppm
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Acute and two-week inhalation toxicity studies in rats for Polyalphaolefin (PAO) fluid J. Toxicol. Environ. Health Part A (IF 2.653) Pub Date : 2020-10-05 David R. Mattie; Matthew D. Wegner; Brian A. Wong; R. Arden James; Karen L. Mumy; Shawn M. McInturf; Barry J. Marcel; Teresa R. Sterner
ABSTRACT Formal occupational exposure limits (OELs) for polyalphaolefin (PAO) fluids have not been proposed. Specific PAO fluids are utilized as aircraft hydraulics or heat sink coolants for electronics and aircraft service air. Toxicity was compared for a PAO fluid in male and female Fischer 344 rats using acute inhalation (0, 100, 500, or 1000 mg/m3 aerosol for 6 hr) and two-week inhalation (0, 20
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Neurotoxicity and physiological stress in brain of zebrafish chronically exposed to tributyltin J. Toxicol. Environ. Health Part A (IF 2.653) Pub Date : 2020-10-05 Ping Li; Zhi-Hua Li
ABSTRACT Tributyltin (TBT), an organotin compound, is hazardous in aquatic ecosystems. However, the mechanisms underlying TBT-induced central nervous system (CNS) toxicity remain to be determined especially in freshwater aquatic vertebrates. The aim of present study was to investigate the effects of chronic exposure to TBT on brain functions in a freshwater teleost the adult wild-type zebrafish (Danio
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Assessment of particulate matter toxicity and physicochemistry at the Claim 28 uranium mine site in Blue Gap, AZ J. Toxicol. Environ. Health Part A (IF 2.653) Pub Date : 2020-10-13 Jessica Begay; Bethany Sanchez; Abigail Wheeler; Floyd Baldwin Jr.; Selita Lucas; Guy Herbert; Yoselin Ordonez Suarez; Chris Shuey; Zachary Klaver; Jack R. Harkema; James G. Wagner; Masako Morishita; Barry Bleske; Katherine E. Zychowski; Matthew J. Campen
ABSTRACT Thousands of abandoned uranium mines (AUMs) exist in the western United States. Due to improper remediation, windblown dusts generated from AUMs are of significant community concern. A mobile inhalation lab was sited near an AUM of high community concern (“Claim 28”) with three primary objectives: to (1) determine the composition of the regional ambient particulate matter (PM), (2) assess
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p-synephrine induces transcriptional changes via the cAMP/PKA pathway but not cytotoxicity or mutagenicity in human gastrointestinal cells J. Toxicol. Environ. Health Part A (IF 2.653) Pub Date : 2020-12-08 Diego Luis Ribeiro; Ana Rita Thomazela Machado; Carla Machado; Alexandre Ferro Aissa; Patrick Wellington Dos Santos; Gustavo Rafael Mazzaron Barcelos; Lusânia Maria Greggi Antunes
ABSTRACT p-Synephrine (SN) is an alkaloid added to thermogenic formulations for weight loss that is predominantly absorbed in the human gastrointestinal tract (GI). As the adverse effects of SN on GI cells remain unclear, the aim of present study was to examine whether SN affected cell viability, cell cycle kinetics, genomic stability, redox status, and expression of cAMP/PKA pathway genes related
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Chemophobia and knowledge of toxicological principles in South-Korea: perceptions of trace chemicals in consumer products J. Toxicol. Environ. Health Part A (IF 2.653) Pub Date : 2020-12-08 Angela Bearth; Seok Kwon; Michael Siegrist
ABSTRACT Many consumer products are manufactured or synthesized from chemicals. However, consumers may be hesitant to purchase consumer products that are perceived as synthetic or derived with chemical substances. Prior studies suggested a preference for chemicals of natural origin and an irrational fear of synthetic chemicals, a phenomenon that is referred to as chemophobia. The aim of this study
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Reactive astrogliosis in the dentate gyrus of mice exposed to active volcanic environments J. Toxicol. Environ. Health Part A (IF 2.653) Pub Date : 2020-12-07 A. Navarro; M. García; A.S. Rodrigues; P.V. Garcia; R. Camarinho; Y. Segovia
ABSTRACT Air pollution has been associated with neuroinflammatory processes and is considered a risk factor for the development of neurodegenerative diseases. Volcanic environments are considered a natural source of air pollution. However, the effects of natural source air pollution on the central nervous system (CNS) have not been reported, despite the fact that up to 10% of the world’s population
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Change in risk of hospital admissions for ischemic heart disease after the implementation of a mass rapid transit system in Taipei J. Toxicol. Environ. Health Part A (IF 2.653) Pub Date : 2020-12-03 Chih-Cheng Chen; Shang-Shyue Tsai; Chun-Yuh Yang
ABSTRACT Numerous epidemiologic studies demonstrated an association between an increase in levels of fine particles (particulate matter less than 2.5 um in diameter, PM2.5) and elevation in the number of hospital admissions for cardiovascular diseases. Air pollution levels including PM2.5 clearly decreased in Taipei City after the mass rapid transit (MRT) system began operations in 1996. The aim of
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Chemopreventive effect of troxerutin against hydrogen peroxide-induced oxidative stress in human leukocytes through modulation of glutathione-dependent enzymes J. Toxicol. Environ. Health Part A (IF 2.653) Pub Date : 2020-10-25 Bruno Coêlho Cavalcanti; João Batista de Andrade Neto; Antônio Adailson de Sousa Silva; Francisco Stefânio Barreto; José Roberto de Oliveira Ferreira; Hemerson Iury Ferreira Magalhães; Cecília Rocha da Silva; Ícaro Gusmão Pinto Vieira; Nágila Maria Pontes Silva Ricardo; Hélio Vitoriano Nobre Júnior; Manoel Odorico Moraes
ABSTRACT Troxerutin is a natural flavonoid present abundantly in tea, coffee, olives, wheat, and a variety of fruits and vegetables. Due to its diverse pharmacological properties, this flavonoid has aroused interest for treatment of various diseases, and consequently prompted investigation into its toxicological characteristics. The aim of this study was to evaluate the genotoxic and mutagenic effects
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Combined treatment with auranofin and trametinib induces synergistic apoptosis in breast cancer cells J. Toxicol. Environ. Health Part A (IF 2.653) Pub Date : 2020-10-25 Min-Kyung Joo; Sangyun Shin; Dong-Jin Ye; Hong-Gyu An; Tae-Uk Kwon; Hyoung-Seok Baek; Yeo-Jung Kwon; Young-Jin Chun
ABSTRACT Auranofin is a gold complex used as an anti-rheumatic agent and may act as a potent anticancer drug against breast tumors. Trametinib is a specific mitogen-activated protein kinase inhibitor, approved for the treatment of metastatic melanoma. The aim of this study was to examine the synergistic effects of auranofin and trametinib on apoptosis in MCF-7 human breast cancer cells. The combination
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Cellular and biochemical antileukemic mechanisms of the meroterpenoid Oncocalyxone A J. Toxicol. Environ. Health Part A (IF 2.653) Pub Date : 2020-10-22 Aline Borba Sbardelotto; Francisco Washington Araújo Barros-Nepomuceno; Bruno Marques Soares; Bruno Coêlho Cavalcanti; Rayran Walter Ramos de Sousa; Marcília Pinheiro da Costa; Otília Deusdênia Loiola Pessoa; Cláudia Pessoa; Paulo Michel Pinheiro Ferreira
ABSTRACT Oncocalyxone A, a 1,4-benzoquinone derived from Cordia oncocalyx, exhibits anti-inflammatory, antimicrobial and antidiabetic properties. The aim of this study was to (1) examine the cytotoxic actions of oncocalyxone A on human normal and tumor cell lines and (2) determine mechanistic actions underlying effects upon leukemia cells using cellular and molecular techniques. Antiproliferative studies
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Erythromycin in the aquatic environment: deleterious effects on the initial development of zebrafish J. Toxicol. Environ. Health Part A (IF 2.653) Pub Date : 2020-10-18 Valeska Toffolo Minski; Cristiane Garbinato; Nathana Thiel; Anna Maria Siebel
ABSTRACT Due to the large volume of erythromycin continuously reaching waterbodies and its high persistence, this antibiotic drug has been detected in the aquatic environment at elevated concentrations. Although the problem of the presence of erythromycin in the environment is evident due to its influence in development of antimicrobial resistance, the toxicological consequences on non-target organisms
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Hand-to-mouth and other hand-to-face touching behavior in a quasi-naturalistic study under controlled conditions J. Toxicol. Environ. Health Part A (IF 2.653) Pub Date : 2020-10-12 Ryan C. Lewis; Robert Rauschenberger; Renee Kalmes
ABSTRACT Data gaps exist in our understanding of hand-to-mouth touching behavior among adults, despite its relevance for accurately characterizing inadvertent ingestion exposures to chemical and pathogenic microbial agents and consequent associated health risks. The present study describes detailed observations of the frequency and nature of hand-to-mouth and other hand-to-face touching behavior among
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Antimicrobial activity of plant extracts against carbapenem-producing Klebsiella pneumoniae and in vivo toxicological assessment J. Toxicol. Environ. Health Part A (IF 2.653) Pub Date : 2020-09-27 Nathalie Gaebler Vasconcelos; Márcia Soares Mattos Vaz; Joyce Alencar Santos Radai; Candida Aparecida Leite Kassuya; Anelise Samara Nazari Formagio; Fernanda Silva Graciani; Maria Lorenza Leal; Rodrigo Juliano Oliveira; Kesia Esther da Silva; Julio Croda; Simone Simionatto
ABSTRACT The global spread of multidrug-resistant strains has prompted the scientific community to explore novel sources of chemicals with antimicrobial activity. The aim of the study was to examine the antimicrobial activity in vitro of 28 extracts against carbapenem-producing Klebsiella pneumoniae, individually and in combination with antibiotics and in vivo toxicological assessment of the most active
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Phytochemical and antioxidant characterization, cytogenotoxicity and antigenotoxicity of the fractions of the ethanolic extract of in Poincianella bracteosa (Tul.) L.P. Queiroz J. Toxicol. Environ. Health Part A (IF 2.653) Pub Date : 2020-09-30 Jamilson dos Santos Freire; Bianca Cristina dos Santos Fernandes; Julia Adelaide Cardeal da Silva; José Rafael da Silva Araújo; Pedro Marcos de Almeida; Joaquim Soares da Costa Júnior; Jurandy Nascimento da Silva; Sâmya Danielle Lima de Freitas; Francielle Alline Martins
ABSTRACT Poincianella bracteosa has been widely used in folk medicine to treat catarrhal infections, diarrhea, and anemia; however, phytochemical and toxicogenetic data are still lacking. The objective of this study was to examine the phytochemical and antioxidant characteristics as well as assess cytogenotoxicity and antigenotoxicity in hexane (HF), ether (EF) and ethyl acetate (AF) fractions of P
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Peat smoke inhalation alters blood pressure, baroreflex sensitivity, and cardiac arrhythmia risk in rats J. Toxicol. Environ. Health Part A (IF 2.653) Pub Date : 2020-10-05 Brandi L. Martin; Leslie C. Thompson; Yong Ho Kim; Charly King; Samantha Snow; Mette Schladweiler; Najwa Haykal-Coates; Ingrid George; M. Ian Gilmour; Urmila P Kodavanti; Mehdi S. Hazari; Aimen K. Farraj
ABSTRACT Wildland fires (WF) are linked to adverse health impacts related to poor air quality. The cardiovascular impacts of emissions from specific biomass sources are however unknown. The purpose of this study was to assess the cardiovascular impacts of a single exposure to peat smoke, a key regional WF air pollution source, and relate these to baroreceptor sensitivity and inflammation. Three-month-old
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Letter to the editor regarding Wultsch et al., "Induction of chromosomal damage in exfoliated buccal and nasal cells of road markers." J. Toxicol. Environ. Health Part A (IF 2.653) Pub Date : 2020-08-24 Tomasz E Burghardt,Birgit Köck,Anton Pashkevich
(2020). Letter to the editor regarding Wultsch et al., “Induction of chromosomal damage in exfoliated buccal and nasal cells of road markers.”. Journal of Toxicology and Environmental Health, Part A: Vol. 83, No. 23-24, pp. 764-765.
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Response to letter to the editor. J. Toxicol. Environ. Health Part A (IF 2.653) Pub Date : 2020-08-24 Siegfried Knasmueller
(2020). Response to letter to the editor. Journal of Toxicology and Environmental Health, Part A: Vol. 83, No. 23-24, pp. 766-768.
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Licochalcone A, a licorice flavonoid: antioxidant, cytotoxic, genotoxic, and chemopreventive potential. J. Toxicol. Environ. Health Part A (IF 2.653) Pub Date : 2020-09-04 Karoline Soares de Freitas,Iara Silva Squarisi,Nathália Oliveira Acésio,Heloiza Diniz Nicolella,Saulo Duarte Ozelin,Matheus Reis Santos de Melo,Ana Paula Prado Guissone,Gabriela Fernandes,Lívia Mara Silva,Ademar Alves da Silva Filho,Denise Crispim Tavares
ABSTRACT Licochalcone A (LicoA) is a flavonoid derived from Glycyrrhiza spp. plants. The present study aimed to investigate the antioxidant, cytotoxic, genotoxic, and chemopreventive effects of LicoA in in vitro and in vivo systems. The results showed that LicoA (197.1 μM) scavenged 77.92% of free radicals. Concentrations of 147.75 µM or higher LicoA produced cytotoxicity in Chinese hamster ovary (CHO)
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Toxicity and human health assessment of an alcohol-to-jet (ATJ) synthetic kerosene. J. Toxicol. Environ. Health Part A (IF 2.653) Pub Date : 2020-09-04 David R Mattie,Brian A Wong,Karen L Mumy,Shawn M McInturf,Michael D Grimm,Nathan M Gargas,Linda M Shafer,Richard C Striebich,Teresa R Sterner
ABSTRACT A toxicological investigation was conducted for alcohol-to-jet (ATJ) fuels intended as a 50:50 blend with petroleum-derived fuel Jet Propulsion (JP)-8. The ATJ synthetic paraffinic kerosene (SPK) fuel was produced by Gevo (Englewood CO) and derived either from biomass (bio) or non-biomass sources. All toxicity tests were performed with one or both ATJ fuels following addition of a standard
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Performance of HepaRG and HepG2 cells in the high-throughput micronucleus assay for in vitro genotoxicity assessment J. Toxicol. Environ. Health Part A (IF 2.653) Pub Date : 2020-09-27 Xiaoqing Guo; Ji-Eun Seo; Dayton Petibone; Volodymyr Tryndyak; Un Jung Lee; Tong Zhou; Timothy W. Robison; Nan Mei
ABSTRACT The micronucleus (MN) assay is a core test used to evaluate genotoxic potential of xenobiotics. The traditional in vitro MN assay is usually conducted in cells lacking metabolic competency or by supplementing cultures with an exogenous rat S9 metabolic system, which creates a significant assay limitation for detecting genotoxic metabolites. Our previous study demonstrated that compared to
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Publisher’s Note J. Toxicol. Environ. Health Part A (IF 2.653) Pub Date : 2020-10-05
(2020). Publisher’s Note. Journal of Toxicology and Environmental Health, Part A: Vol. 83, No. 21-22, pp. 718-718.
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Development of a physiologically based pharmacokinetic model of diisononyl phthalate (DiNP) in pregnant rat and human. J. Toxicol. Environ. Health Part A (IF 2.653) Pub Date : 2020-08-06 Jerry L Campbell,Rainer Otter,Warwick A Anderson,Matthew P Longnecker,Rebecca A Clewell,Colin North,Harvey J Clewell
A physiologically based pharmacokinetic (PBPK) model for di-isononyl phthalate (DiNP) was developed by adapting the existing models for di(2-ethylhexyl) phthalate (DEHP) and di-butylphthalate (DBP). Both pregnant rat and human time-course plasma and urine data were used to address the hydrolysis of DiNP in intestinal tract, plasma, and liver as well as hepatic oxidative metabolism and conjugation of
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In vivo immune activation of splenocytes following exposure to tar from Asian sand dust. J. Toxicol. Environ. Health Part A (IF 2.653) Pub Date : 2020-08-20 Mengyue Shen,Yuan Song,Takamichi Ichinose,Kentaro Morita,Duo Wang,Keiichi Arashidani,Yasuhiro Yoshida
Air pollution, especially that initiated by particulate matter (PM), has been implicated as a risk factor for several inflammatory diseases. Previously, it was reported that PM enhances immune responses. PM includes the tar fraction that contains polycyclic aromatic hydrocarbons (PAHs), which produce adverse health effects in exposed individuals. However, the influence of the tar fraction (as a component
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In vivo and in vitro toxicological evaluations of aqueous extract from Cecropia pachystachya leaves. J. Toxicol. Environ. Health Part A (IF 2.653) Pub Date : 2020-08-30 Erminiana Damiani de Mendonça Pereira,Juliana da Silva,Patrícia da Silva Carvalho,Ivana Grivicich,Jaqueline Nascimento Picada,Ilton Batista Salgado Júnior,Gabriela Jouglard Vasques,Mário Augusto da Silva Pereira,Flavio Henrique Reginatto,Alexandre de Barros Falcão Ferraz
Cecropia pachystachya leaves are popularly used to treat asthma and diabetes. Despite the widespread consumption of this plant, there are few scientific studies regarding its toxicological potential. In order to conduct a thorough study concerning the potential adverse effects, the aim of this study was to assess acute and subacute toxicity tests of crude aqueous extract from C. pachystachya leaves
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Statement of Retraction: [On the assessment of exposure to airborne ultrafine particles in urban environments]. J. Toxicol. Environ. Health Part A (IF 2.653) Pub Date : 2020-09-02
(2020). Statement of Retraction: [On the assessment of exposure to airborne ultrafine particles in urban environments]. Journal of Toxicology and Environmental Health, Part A. Ahead of Print.
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Citrate ester substitutes for di-2-ethylhexyl phthalate: In vivo reproductive and in vitro cytotoxicity assessments. J. Toxicol. Environ. Health Part A (IF 2.653) Pub Date : 2020-07-29 Chi Rim Sung,Hyeon Gyu Kang,Ji Young Hong,Seung Jun Kwack
Di-2-ethylhexyl phthalate (DEHP) is frequently used as a plasticizer for wrapping films, in toys, and in medical devices. Previous studies demonstrated that DEHP in mouse reduced testicular and epididymis weights, suppressed levels of serum testosterone, luteinizing hormone, and follicle-stimulating hormone, and decreased synthesis of testosterone by Leydig cells. Due to these anti-androgenic effects
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Association between ozone air pollution levels and hospitalizations for depression in Taipei: a time-stratified case-crossover study. J. Toxicol. Environ. Health Part A (IF 2.653) Pub Date : 2020-08-06 Shang-Shyue Tsai,Ya-Wen Chiu,Yi-Hao Weng,Chun-Yuh Yang
Epidemiologic studies reported an association between exposure to ambient air pollutants and increased mortality rate attributed to suicide and suicide attempts. The investigation sought to determine whether there is an association between short-term ambient ozone (O3) level exposure and daily hospital admissions for depression in Taipei from 2009 to 2013 using a time-stratified case-crossover design
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Histopathological, cytotoxicological, and genotoxic effects of the semi-synthetic compound dillapiole n-butyl ether in Balb/C mice J. Toxicol. Environ. Health Part A (IF 2.653) Pub Date : 2020-08-13 Daniel Luís Viana Cruz; Tania Cristina Sumita; Mayla Silva Leão Ferreira; Junielson Soares da Silva; Ana Cristina da Silva Pinto; José Fernando Marques Barcellos; Míriam Silva Rafael
Dillapiole n-butyl ether is a substance derived from dillapiole, which exhibits potential insecticidal effects on Aedes aegypti, the principal vector of the Dengue fever, Zika, and Chikungunya viruses, as well as Aedes albopictus, a vector of Dengue fever. As these mosquitoes are resistant to synthetic insecticides, dillapiole n-butyl ether may represent a valuable, plant-based alternative for their
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Diazinon impairs bioenergetics and induces membrane permeability transition on mitochondria isolated from rat liver J. Toxicol. Environ. Health Part A (IF 2.653) Pub Date : 2020-08-13 Camila Araújo Miranda; Anilda Rufino de Jesus Santos Guimarães; Paulo Francisco Veiga Bizerra; Fábio Erminio Mingatto
Diazinon (DZN) is a broad-spectrum insecticide extensively used to control pests in crops and animals. Several investigators demonstrated that DZN produced tissue toxicity especially to the liver. In addition, the mitochondrion was implicated in DZN-induced toxicity, but the precise role of this organelle remains to be determined. The aim of this study was thus to examine the effects of DZN (50 to
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Characterization of the in vitro cytotoxic effects of brachydins isolated from Fridericia platyphylla in a prostate cancer cell line. J. Toxicol. Environ. Health Part A (IF 2.653) Pub Date : 2020-06-26 Higor Lopes Nunes,Katiuska Tuttis,Juliana Mara Serpeloni,Jessyane Rodrigues do Nascimento,Claudia Quintino da Rocha,Viviane Aline Oliveira Silva,André van Helvoort Lengert,Rui Manuel Reis,Ilce Mara de Syllos Cólus
Brachydins (Br) A, B, and C are flavonoids extracted from Fridericia platyphylla (Cham.) L.G. Lohmann roots (synonym Arrabidaea brachypoda), whose extract previously exhibited cytotoxic and antitumor activity. In vitro cell culture of human prostate tumor cell line (PC-3) was used to determine cell viability as evidenced by MTT, neutral red, and LDH release using nine concentrations (0.24 to 30.72 µM)
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Pre-pubertal exposure to ibuprofen impairs sperm parameters in male adult rats and compromises the next generation. J. Toxicol. Environ. Health Part A (IF 2.653) Pub Date : 2020-07-02 Mariana Gazoli Barbosa,Bárbara Campos Jorge,Julia Stein,Dayana Agnes Santos Ferreira,Ana Carolina da Silva Barreto,Ana Carolina Casali Reis,Suyane Da Silva Moreira,Leonardo Cesar De Lima Inocencio,Luis Fernando Benitez Macorini,Arielle Cristina Arena
Ibuprofen is one of the most commonly prescribed anti-inflammatory drugs in pediatric practice. This drug inhibits the cyclooxygenase enzyme, reducing the production of prostaglandin, an important mediator on male reproductive function. We examined if pre-pubertal treatment with ibuprofen in male rats can affect the reproductive parameters of these animals in adult life and on their descendants. Male
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Toxicity and differential oxidative stress effects on zebrafish larvae following exposure to toxins from the okadaic acid group. J. Toxicol. Environ. Health Part A (IF 2.653) Pub Date : 2020-07-19 Diego Figueroa,Ailen Signore,Oscar Araneda,Héctor R Contreras,Miguel Concha,Carlos García
Okadaic acid-group (OA-group) is a set of lipophilic toxins produced only in seawater by species of the Dinophysis and Prorocentrum genera, and characterized globally by being associated with harmful algal blooms (HABs). The diarrhetic shellfish poisoning toxins okadaic acid (OA) and dinophysistoxin-1 (DTX-1) are the most prevalent toxic analogues making up the OA-group, which jeopardize environmental
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Human exposure to synthetic endocrine disrupting chemicals (S-EDCs) is generally negligible as compared to natural compounds with higher or comparable endocrine activity. How to evaluate the risk of the S-EDCs? J. Toxicol. Environ. Health Part A (IF 2.653) Pub Date : 2020-06-18 Herman Autrup,Frank A Barile,Sir Colin Berry,Bas J Blaauboer,Alan Boobis,Herrmann Bolt,Christopher J Borgert,Wolfgang Dekant,Daniel Dietrich,Jose L Domingo,Gio Batta Gori,Helmut Greim,Jan Hengstler,Sam Kacew,Hans Marquardt,Olavi Pelkonen,Kai Savolainen,Pat Heslop-Harrison,Nico P Vermeulen
ABSTRACT Theoretically, both synthetic endocrine-disrupting chemicals (S-EDCs) and natural (exogenous and endogenous) endocrine-disrupting chemicals (N-EDCs) can interact with endocrine receptors and disturb hormonal balance. However, compared to endogenous hormones, S-EDCs are only weak partial agonists with receptor affinities several orders of magnitude lower than S-EDCs. Thus, to elicit observable
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Risk assessment via genotoxicity, metabolism, apoptosis, and cell growth effects in a HepG2/C3A cell line upon treatment with Rubus rosifolius (Rosaceae) leaves extract. J. Toxicol. Environ. Health Part A (IF 2.653) Pub Date : 2020-06-22 Ana Paula Oliveira De Quadros,Laíza Moura Almeida,Marcel Petreanu,Rivaldo Niero,Paulo Cesar Pires Rosa,Alexandra Christinie Helena Frankland Sawaya,Mario Sergio Mantovani,Isabel O'Neill De Mascarenhas Gaivão,Edson Luis Maistro
Rubus rosifolius Sm. (Rosaceae) is a plant traditionally used in Brazil and some other countries to treat diarrhea, stomach diseases, and as an analgesic, antimicrobial, antihypertensive, and as well as other pharmacological properties. The aim of this study was to examine cytotoxic and genotoxic effects of R. rosifolius leaves extract on HepG2/C3A cells and correlate these findings with the expression
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Risk communication for labeling all ingredients in consumer products. J. Toxicol. Environ. Health Part A (IF 2.653) Pub Date : 2020-06-18 Byung-Mu Lee,Mira Choi,Insoo Shin,Jinyong Kim,Zeehyun Choi,Kyoungeun Kim,Kyungmoon Choi,Seyun Yang,Dam Yi So,Seon Tae Ju,Seok Kwon
The labeling of all ingredients contained in consumer products has been requested by consumers concerned regarding their safety. Consequently, regulatory agencies have set guidelines for industries on how to provide safety information regarding the ingredients in their products. However, discordant opinions were raised from stakeholders, resulting in the formation of a risk communication forum among
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Toxicological, chemopreventive, and cytotoxic potentialities of rare vegetal species and supporting findings for the Brazilian Unified Health System (SUS). J. Toxicol. Environ. Health Part A (IF 2.653) Pub Date : 2020-06-22 Jurandy do Nascimento Silva,Nayana Bruna Nery Monção,Ruth Raquel Soares de Farias,Antonia Maria das Graças Lopes Citó,Mariana Helena Chaves,Mônica Regina Silva de Araújo,Daisy Jereissati Barbosa Lima,Claudia Pessoa,Alessandro de Lima,Edigênia Cavalcante da Cruz Araújo,Gardenia Carmen Gadelha Militão,Marcília Pinheiro da Costa,Raffaele Capasso,Paulo Michel Pinheiro Ferreira
Caatinga flora which are found in a poor Brazilian region contain a substantial number of endemic taxa with biomedical and social importance for regional communities. This study examined the antioxidant and cytotoxic potential of 35 samples (extracts/fractions) from 12 Caatinga species and determined the antiproliferative and genotoxic action of dichloromethane fraction from Mimosa caesalpiniifolia
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Effects of anti-wrinkle and skin-whitening fermented black ginseng on human subjects and underlying mechanism of action. J. Toxicol. Environ. Health Part A (IF 2.653) Pub Date : 2020-06-16 Jin Ju Park,Junmin An,Jung Dae Lee,Hyang Yeon Kim,Jueng Eun Im,Eunyoung Lee,Jaehyoun Ha,Chang Hui Cho,Dong-Wan Seo,Kyu-Bong Kim
The aim of this study was to determine the effects of anti-wrinkle and skin-whitening of fermented black ginseng (FBG) in human subjects and to examine underlying biochemical mechanisms of action. A clinical study was performed to evaluate efficacy and safety using a 1% FBG cream formulation. Twenty-three subjects were recruited and instructed to apply control or FBG creams each on half of their face
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The interactions of diet-induced obesity and organophosphate flame retardant exposure on energy homeostasis in adult male and female mice. J. Toxicol. Environ. Health Part A (IF 2.653) Pub Date : 2020-06-16 Gwyndolin M Vail,Sabrina N Walley,Ali Yasrebi,Angela Maeng,Kristie M Conde,Troy A Roepke
Previously, sex-dependent alterations in energy homeostasis were reported in adult mice fed a standard chow attributed to exposure to a mixture of organophosphate flame retardants (OPFRs) via estrogen receptors (ERα). In this study, adult male and female mice (C57BL/6J; Taconic) were treated with the same mixture of OPFRs (1 mg/kg each of tricresyl phosphate (TCP), triphenyl phosphate (TPP), and t
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An in vivo study of nanorod, nanosphere, and nanowire forms of titanium dioxide using Drosophila melanogaster: toxicity, cellular uptake, oxidative stress, and DNA damage. J. Toxicol. Environ. Health Part A (IF 2.653) Pub Date : 2020-06-09 Eşref Demir
The biological impact of nanomaterials (NMs) is determined by several factors such as size and shape, which need to be taken into consideration in any type of analysis. While investigators often prefer to conduct in vitro studies for detection of any possible adverse effects of NMs, in vivo approaches yield more relevant data for risk assessment. For this reason, Drosophila melanogaster was selected
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Effects of anti-wrinkle and skin-whitening fermented black ginseng on human subjects and underlying mechanism of action. J. Toxicol. Environ. Health Part A (IF 2.653) Pub Date : 2020-06-20 Jin Ju Park,Junmin An,Jung Dae Lee,Hyang Yeon Kim,Jueng Eun Im,Eunyoung Lee,Jaehyoun Ha,Chang Hui Cho,Dong-Wan Seo,Kyu-Bong Kim
The aim of this study was to determine the effects of anti-wrinkle and skin-whitening of fermented black ginseng (FBG) in human subjects and to examine underlying biochemical mechanisms of action. A clinical study was performed to evaluate efficacy and safety using a 1% FBG cream formulation. Twenty-three subjects were recruited and instructed to apply control or FBG creams each on half of their face
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A template of information needs for decision-making about delaying remediation on contaminated lands to protect human health J. Toxicol. Environ. Health Part A (IF 2.653) Pub Date : 2020-06-05 Joanna Burger; Michael Gochfeld
The contamination legacy of industrialization, militarization, and nuclear arms race poses current or future risks to populations and the environment. Responsible parties and regulators make decisions regarding which sites to clean up, how, how much, and when. This study aimed to provide an information needs template to evaluate and reduce risks to human health when considering whether to initiate
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Carnosic acid exhibits antiproliferative and proapoptotic effects in tumoral NCI-H460 and nontumoral IMR-90 lung cells. J. Toxicol. Environ. Health Part A (IF 2.653) Pub Date : 2020-05-27 Amanda Cristina Corveloni,Simone Cristine Semprebon,Adrivanio Baranoski,Bruna Isabela Biazi,Thalita Alves Zanetti,Mário Sérgio Mantovani
Carnosic acid (CA) is a phenolic diterpene with many important biological activities including antimicrobial, antioxidant, anti-inflammatory properties, and anti-proliferative properties. The aim of the present study was to investigate cytotoxic activity, cell cycle, apoptotic, and molecular effects attributed to CA in non-tumoral IMR-90 (human fetal lung fibroblasts), as well as tumoral NCI-H460 (human
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Contamination and health risks assessment in a dam in the southeast region of Brazil using ecotoxicological methods J. Toxicol. Environ. Health Part A (IF 2.653) Pub Date : 2020-05-27 Edimar Olegário de Campos Júnior; Drielly Francelina Araújo; Henrique Nazareth Souto; Carlos Fernando Campos; Boscolli Barbosa Pereira
Concerned with water quality, specialists have resorted to ecotoxicology as a tool to assess suspected contamination, enabling creation of strategies to repair the observed damage. Organisms such as fish and micro crustaceans are widely used in acute tests due to several characteristics in common among them including (1) accessibility of multiple samples, and (2) enhanced sensitivity when exposed to
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Impact of stressors in the aviation environment on xenobiotic dosimetry in humans: physiologically based prediction of the effect of +Gz-forces. J. Toxicol. Environ. Health Part A (IF 2.653) Pub Date : 2020-05-22 Lisa M Sweeney
The application of physiologically based modeling approaches in evaluating health risks in diverse environments is limited by scarcity of comprehensive reviews detailing how physiological parameters are altered due to stressors. A modern high-performance aviation environment in particular has the potential for simultaneous exposure to chemical and non-chemical stressors which may interact via non-chemical
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Effects of ambient ozone exposure on circulating extracellular vehicle microRNA levels in coronary artery disease patients. J. Toxicol. Environ. Health Part A (IF 2.653) Pub Date : 2020-05-15 Hao Chen,Yunan Xu,Ana Rappold,David Diaz-Sanchez,Haiyan Tong
Exposure to ambient air pollutants such as ozone (O3) and particulate matter (PM) is associated with increased cardiovascular morbidity and rate of mortality, but the underlying biological mechanisms have yet to be described. Emerging evidence shows that extracellular vehicle (EV) microRNAs (miRNAs) may facilitate cell-to-cell and organ-to-organ communications and play a role in the air pollution-induced